LOCUS       ACJE01000001.1         18438 bp    DNA     linear   PLN 19-AUG-2019
DEFINITION  Aspergillus niger.
ACCESSION   ACJE01000001
VERSION     ACJE01000001.1
KEYWORDS    .
SOURCE      Aspergillus niger
  ORGANISM  Aspergillus niger
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Eurotiomycetes; Eurotiomycetidae; Eurotiales; Aspergillaceae;
            Aspergillus.
COMMENT     'Annotated using funannotate v1.6.0-df4262f'.
            ##antiSMASH-Data-START##
            Version      :: 5.0.0
            Run date     :: 2020-11-02 06:16:28
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: <588980
            Orig. end    :: >607418
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    <1..>18438
                     /aStool="rule-based-clusters"
                     /contig_edge="False"
                     /core_location="[<597332:>598289](+)"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      <8353..>9309
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     cand_cluster    <1..>18438
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     region          <1..>18438
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="4"
                     /rules="(Terpene_synth or Terpene_synth_C or phytoene_synt
                     or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps
                     or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /tool="antismash"
     mRNA            join(<1..21,85..222,279..579,659..>1737)
                     /locus_tag="ASPNIDRAFT_122043"
                     /product="hypothetical protein"
     gene            <1..>1737
                     /locus_tag="ASPNIDRAFT_122043"
     CDS             join(<1..21,85..222,279..579,659..>1737)
                     /codon_start=1
                     /db_xref="PFAM:PF01593"
                     /locus_tag="ASPNIDRAFT_122043"
                     /product="hypothetical protein"
                     /protein_id="ncbi_ASPNIDRAFT_122043-T1"
                     /transl_table=1
                     /translation="MAGIAAAQALSNASIDDFIILEYRDTLGGRVWHTDFGKDKQGKPY
                     VIELGANWLQGLGSEAIENPVWALAKKYRLKNTYSNYSSIRTYNETGYTDYRYLLDEYA
                     QAYHIAARDAGRILTQNLQDQTARTGLALAGWRPRKNDMAAQAVEWWSWAHPRLTHIPK
                     LDWEDAHTPETSSLVFGIAGENLTFNQFGKANHLVLDPRGYSTIIQNEALGFLPNPSDG
                     RLRLNTRVTRIEYSPRGVTIHTTNDNNKNSNTCIRAAYAICTFSLGVLQNKAVTFDPPL
                     PSWKQTAIEKFNMGTYTKIFMQFPETFWPTDTQFFLYASPTTRGYYPVFQSLSTENFLP
                     ESNILFATVVDEQAYRVERQSLTQTKDQILNVLREMFPDKHIPEPTAFTYPRWTNEPWV
                     YGSYSNWPAGTTLEMHQNLRANTGRLWFAGEATSAAYFGFLHGAWYEGRDAGENVAALL
                     QGRCVEDVSTTSTASGKEEKEEACGERVFYEQLNGTTPLDAYSRLNGWPAVSYY"
     mRNA            complement(join(<2260..2367,2445..>3908))
                     /locus_tag="ASPNIDRAFT_43398"
                     /product="hypothetical protein"
     gene            complement(<2260..>3908)
                     /locus_tag="ASPNIDRAFT_43398"
     CDS             complement(join(<2260..2367,2445..>3908))
                     /codon_start=1
                     /db_xref="PFAM:PF07690"
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 73.1; E-value:
                     2.4e-22)"
                     /gene_kind="transport"
                     /locus_tag="ASPNIDRAFT_43398"
                     /note="EggNog:ENOG41"
                     /product="hypothetical protein"
                     /protein_id="ncbi_ASPNIDRAFT_43398-T1"
                     /transl_table=1
                     /translation="MATCTEKYSPTPTEVFQDHIASNESDTATLSWDDDNDPENPYNWS
                     VGRKWTLTCLAAFTTFLAMMNGTIITVAHFEISEHFHVNEDAFPNSYWPVTTWATGGAC
                     SALFILPLAEDFGTRPIFLTTYLLFICFLVPQAVAHNFATLVVTRFFAGGCVAILANTA
                     AGVVGNLWSTEWSRSIPVSLYILGYMSGSSTGPVIGAAIFHSLGWRWISYMQLIWFGAL
                     FPIYYFFLHESRGSAILARRARRNRKNGDETSGYAGSGDVSSRLNLHSLVVSATRPVIL
                     FSTEPVLFVSTLWSAFTVGTLFLFTQSVEQVFMGLYNWDVSQTGYVQCAIVIGECLGWL
                     VNFLSRKLYFASASRNTEVPGTPIPEARLYMAVVGGVLGLSGGMFIYAWTSYSSLPWIA
                     PTVGLALVGAGSVCVVTGVSDYVVDSYSQFSGSAMGAVAAGENVFSAFLPLATMSMYRV
                     LGYQWASTLLAFICLVLSLIPTLMFVWGKELLAETRTSDGCNSELGNIIASDGEGRSGW
                     TVGSYY"
     mRNA            complement(join(<5488..5644,5701..>6959))
                     /locus_tag="ASPNIDRAFT_122639"
                     /product="hypothetical protein"
     gene            complement(<5488..>6959)
                     /locus_tag="ASPNIDRAFT_122639"
     CDS             complement(join(<5491..5644,5701..>6959))
                     /codon_start=1
                     /db_xref="PFAM:PF00067"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 313.8; E-value: 3.5e-95)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ASPNIDRAFT_122639"
                     /note="EggNog:ENOG41"
                     /product="hypothetical protein"
                     /protein_id="ncbi_ASPNIDRAFT_122639-T1"
                     /sec_met_domain="p450 (E-value: 1.7e-60, bitscore: 200.1,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MVTYNLFIHPLKEVPGPRMLAASRIPVTYASLKGIQTQWLHNLHL
                     KYGPVLRVAPNELSFIDPQAWKDIYSSSPTEPQSMRRGSDFFRYLEDDDNRPSILAANE
                     IDHPRIRRAYVPAFSRRALARQESILAKYGDALVERLSGIEGQITNIRNMFHYTLFDIV
                     GHLHFGEELGVLRTGAHKSWVHSQHRLVRAATLLSALAEFSWINLLFRSTIPWMSKWLR
                     KAYFKPSNDLIDRRLQLQSDEPDLIGLAFRNSRSLSLTEKDIRANAHIMMTGGAETTTA
                     LMTALTAYLLQHPECLARLKNDIRTAFHDKSQVSLESVSNLAYLDACIKEALRLYPSVP
                     GALHRATPAGGARIAGRWVSGNTRVYIPIFAATHSPTHFWSPDKFIPDRWLDGADDPYQ
                     KDNKTAFHPFSTGPRGCIGQDMAYAMTKIVFCKFVTEFDCELAVNESSPWLAGHRSWTT
                     WEVPPLMVRVSRC"
     mRNA            <8353..>9309
                     /locus_tag="ASPNIDRAFT_43396"
                     /product="hypothetical protein"
     gene            <8353..>9309
                     /locus_tag="ASPNIDRAFT_43396"
     CDS             <8353..>9309
                     /codon_start=1
                     /db_xref="PFAM:PF06330"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: TRI5"
                     /gene_kind="biosynthetic"
                     /locus_tag="ASPNIDRAFT_43396"
                     /note="EggNog:ENOG41"
                     /product="hypothetical protein"
                     /protein_id="ncbi_ASPNIDRAFT_43396-T1"
                     /sec_met_domain="TRI5 (E-value: 5.6e-27, bitscore: 89.6,
                     seeds: 3, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MTKAQTAVSPDEFFKIITPFLNEIIPNIPPFAPDEAFYKAVFDKF
                     AAASGLPEDSIPHFVGTGEVLARCFYPSLPRDLQISIGVLTAYVFSIDDQCADPEFREQ
                     IKSYRSVFLGQSTTNLQYIKGLYNTLHDIVSHYEWYAGDMIIKSTMDFVSINIVEAEQT
                     GDFMVSPSTKLFPDFLRQKSGIGEAYAFFYFPGSDWGLGDYFTLIPDIAGIIEQLNDVL
                     SFYKESVLGNEPGTWVKQTCVCKGISEGEAFRERVDQCLGSIRRLRAASEGNPRLLKTV
                     NEFINGYPLFHLNAGRYKLDQFGSYHGWQGEKTAGGN"
     mRNA            complement(join(<9610..10948,11013..>11617))
                     /locus_tag="ASPNIDRAFT_120523"
                     /product="hypothetical protein"
     gene            complement(<9610..>11617)
                     /locus_tag="ASPNIDRAFT_120523"
     CDS             complement(join(<9615..10948,11013..>11617))
                     /codon_start=1
                     /db_xref="PFAM:PF04082"
                     /locus_tag="ASPNIDRAFT_120523"
                     /note="EggNog:ENOG41"
                     /product="hypothetical protein"
                     /protein_id="ncbi_ASPNIDRAFT_120523-T1"
                     /transl_table=1
                     /translation="LDCINEDFNKDEISQATGYIGQSSEISWIHSLGRDINGDTEHGTP
                     SEAIFLSISDSSPISASNYHVDDQELPNIERQEAYALPSKDVASKLYNCYLDWVHPTFP
                     IIGTTPFGKQFHAFFNDTRLHTGNKWLAVLNLLFAIAARYAYISEAEWQLNKNNHWLYF
                     SRARVLSIDDWSFHHPDLQQLQVEGLTALYMLSLGHVNRAWRICGSAVRGALGLGLHLR
                     NMSKSASDTSREIRYRVWWSLYTLDHRLSIITGRPSFIDDTVYTTPLPVPFDEKDFGKD
                     EVINCLRFSHGTEGIHTDFDLMGKHSIAISKGTGAISGPPSGSLHFFHVIRLMLISKKM
                     ITKLYSPSAASTSWMGIEFAIQGLTSDIESWLLSLPNEFDFTSTQSTQVTHSISNHRMS
                     LAFIFYSTKIGITRPCLRRPNPVNQDGKTPDEKIQDFCQRTAAECVESACHMLRLFPDG
                     LDAAALYRMSPWWCILHFLVQATTVLLMELSFGVCHVPEKASMVSKATERALKWLAILA
                     NTNAASEKARLLCEGLLRRIEQYAGVNLPNPPIPSRFGTSVTPGPGPTGLSSAPEPQTN
                     ELGCGPLPLSDPSTSLEAHLKGQPASESPDLMHTDKDTTAQDTYDESLPYDPSTGQIIG
                     SFFPPNLGLGL"
     mRNA            join(<17257..17314,17540..>18438)
                     /locus_tag="ASPNIDRAFT_43394"
                     /product="hypothetical protein"
     gene            <17257..>18438
                     /locus_tag="ASPNIDRAFT_43394"
     CDS             join(<17257..17314,17540..>18438)
                     /codon_start=1
                     /locus_tag="ASPNIDRAFT_43394"
                     /product="hypothetical protein"
                     /protein_id="ncbi_ASPNIDRAFT_43394-T1"
                     /transl_table=1
                     /translation="MTSISAGDDTTTLLPGRNRTSFLPLETPLETIPSLPKFRPKHLRH
                     RLPSKAPLHRRLYSPSALSTKSSVPILTIYKMAPILLSNNIRTPFRYLNRIIHLRKGED
                     KGKTRAQPDLSSALTRLFANSENDDEESSITHITESTSQIWVEDQDPALVDLLATLSFT
                     ITTSTSDSSTLLALLASALDILSTYAQNHKVNTLPIYTALLRHLDTYTSYLIWDHEILL
                     TDAEIIFTASSIPTPKHRDNIILQLESAYVSNYETCKTLVTRLNQLVDIELMERADWIF
                     PRQIGWVEVRREVIRLEKTLKEIRWAGKLKEVEYVNC"
ORIGIN
        1 atggccggca ttgcagctgc agtaggtgac cctcaggccc ctttgcccta aatcccgacc
       61 ggcaatgctc accaacacgt ctagcaagcc ttgtccaacg catctatcga cgactttatc
      121 atcctcgaat atcgcgatac cctaggtggc cgtgtctggc atacggactt cggcaaggat
      181 aaacaaggca agccatacgt gattgagcta ggagccaact gggtatgaca atctacatac
      241 atcccgtcaa atgaacatcc gcctcaccat aacaacagct ccaaggactc ggctccgaag
      301 ctatcgagaa tccagtctgg gcactagcca aaaaataccg tctcaaaaac acctactcta
      361 actacagctc catccgaaca tacaacgaaa ccggctacac cgactaccgc tatttgctcg
      421 acgaatacgc gcaagcctac cacattgccg cccgcgatgc tggccgcatt ctgacccaga
      481 acctacaaga ccaaaccgca cgcaccgggc tcgccctcgc cggctggaga ccacgcaaga
      541 atgacatggc ggcacaagcc gtggaatggt ggagctgggg tatgaacaat taccattaag
      601 agggggaaca cccaaccctt tttacaccca tcgggtcaac accaacccta tcccatagcc
      661 caccctcgac taacgcatat cccaaaacta gactgggaag acgcacatac gcccgaaacc
      721 agctccttgg tcttcggcat cgccggtgag aacctaacct tcaaccaatt cggcaaagcc
      781 aaccacctcg tcctcgaccc gcgcggctac agcaccatca ttcaaaacga agccctcggt
      841 ttcctaccca acccctctga tggccgccta cgcctaaaca cccgcgtcac tcgcattgaa
      901 tactccccaa ggggcgtaac aatccacacc accaacgaca acaacaaaaa cagcaacacc
      961 tgcatccgag cggcctacgc aatctgcacc ttctccctgg gcgtcctcca aaacaaagcc
     1021 gtaaccttcg acccaccttt gccctcctgg aaacaaaccg ccatcgagaa attcaacatg
     1081 ggcacctaca ccaagatatt catgcaattc cctgagacct tttggcccac agacacgcaa
     1141 tttttcctat acgcttcccc aacaacaaga ggctactacc ctgtcttcca atccctctcc
     1201 acagagaact tcctccctga atcaaacatc ctcttcgcca ccgtggtcga cgaacaagcc
     1261 taccgcgttg aacgccaatc cttgactcaa acgaaggacc agatcctcaa tgttctaaga
     1321 gagatgttcc ctgataaaca catccctgag cctacggcgt ttacttaccc ccgctggacg
     1381 aatgaaccct gggtctacgg cagctactcc aactggccgg cgggaacgac ccttgagatg
     1441 catcagaatc tgcgggcgaa tacgggccgg ctgtggttcg caggcgaagc gaccagtgcg
     1501 gcgtatttcg ggttcttgca tggtgcgtgg tatgaggggc gcgatgcggg tgagaatgtt
     1561 gccgcgctgt tgcaggggag gtgtgttgag gatgttagta ctactagtac tgctagtggg
     1621 aaagaagaga aggaggaagc gtgtggagag agggtctttt atgagcaatt aaatgggact
     1681 acgccgctgg atgcgtatag tcggttgaac gggtggccgg cggtaagtta ctactagaag
     1741 tggtatggct ttgtagggtc tgctttagtt gttggataga ttggatggat gaatggcgtt
     1801 ggcatgggaa attacttttt tggaatttca tattagtctg catcatgtaa cgcaataatt
     1861 tgggattata catcaactgg cctgctggcc caatggtaag gcgcttgact acggatcaag
     1921 agattgcagg ttcgagtcct gcgtaggtca ttctttttgc ttttttctta ggtggagagt
     1981 ggatctggta cggtggggcg ccttccgtac gggtactatc gctggaaatt atctactcgt
     2041 acagtcgcct ttctctgcgc tcaggttttc tttggggggt gtggtatgaa tcggcatctt
     2101 aagtcggttc ctgtcctttg ttatagcata tgcataattc tcatcatagt ctcctagcaa
     2161 ggtgctaccc aatggagttc aatgtcgtat taatcccctc aaactactag tatgctatca
     2221 atagtatata tttcgggcaa ctactacttc attctaggat cagtagtagc taccaaccgt
     2281 ccagcctgaa cgcccttcac cgtctgaagc aataatgttg cccaattcgc tattgcatcc
     2341 atcgctagtt cgtgtttctg ccaatagcta ccttaaacaa cctctgaccg tttcttcgtt
     2401 gcatcattcg ccatctcatt cataaaagca ctccgtgcac gtacctcctt cccccagaca
     2461 aacattaatg taggtataag cgacaacacc aagcaaataa aggcaagtag cgtactagcc
     2521 cactgatatc ctagcacccg gtacatgctc atcgttgcga ggggcaagaa agcagagaag
     2581 acattctctc ccgcagcaac agcacccatg gcacttcctg aaaactgact gtaagagtcg
     2641 accacatagt ctgatactcc agtcacgaca caaacactgc cagcacctac caaggccaag
     2701 ccaacagtag gtgcaatcca tggaagactc gaatatgaag tccaagcata gatgaacata
     2761 ccgcccgaga gaccgagaac ccctcccacc acagccatgt atagcctcgc ctctgggatt
     2821 ggagttcccg gcacctcggt atttctggaa gcagacgcga aatagagctt ccgagaaagg
     2881 aagttcacta gccagcctag acattctccg atgacgatgg cgcattgaac ataaccggtt
     2941 tgtgaaacgt cccagttata taggcccatg aacacctgct caacggactg ggtaaagagg
     3001 aaaagagtcc ccactgtgaa agcggaccaa agggtcgaca cgaagagaac cggctccgta
     3061 gaaaataaaa tcaccggtct tgtcgcgctg actacaagac tatgcaggtt caaacgagag
     3121 gaaacatccc cgctccctgc ataaccgctg gtctcgtcgc cattcttgcg attacgtcgt
     3181 gctcgtcgtg caagaatcgc gctgccacgc gactcatgaa ggaagaagta atagattgga
     3241 aagagagccc cgaaccaaat gagctgcata tagctaatcc acctccagcc taaagagtgg
     3301 aatatcgcgg cgccaatcac ggggcctgta ctgctgccgc tcatgtaacc gagaatatat
     3361 agactgactg ggatggacct ggaccactca gtgctccata gatttccgac aacaccggcg
     3421 gcggtattgg ccaggatagc gacacagccg ccggcgaaaa agcgggtgac cactaatgtt
     3481 gcgaagttat gagcaacggc ttgaggcacc aggaagcaaa taaataatag atatgttgtg
     3541 aggaagatag gcctcgtccc gaaatcctct gctaggggaa gaatgaataa agctgagcat
     3601 gcaccgccgg tagcccatgt tgttaccggc cagtaagaat taggaaatgc atcctcgttg
     3661 acatggaagt gttctgagat ctcgaagtgc gccacagtaa tgatggttcc gttcatcatc
     3721 gccaggaagg tagtgaaagc agcgaggcat gtcagggtcc atttccgtcc cactgaccag
     3781 ttgtaggggt tttcgggatc attatcgtca tcccaagaga gagtcgcggt gtcactttca
     3841 tttgacgcga tatggtcttg gaagacttcg gtcggggttg gagaatattt ctctgtgcag
     3901 gttgccatgt attcgttgtg cttggttctt actgctcacg ataattcacg agtgtatgtc
     3961 aaatagagat agtaatcatc cgccatatgg ctatggaccc tactgtatga cctatatatc
     4021 attgacagca acatatccag ggctttgtga agcgtcttgc ttctcacaat agtgcccttt
     4081 ttgggaatag ttaattgata gttacttata gtcttggctt gatgcagcgg agccctatcg
     4141 ggaaggctga tggatgcaac tttgcggtaa ctcgcttgac ttcgggttcg tgagccgatt
     4201 agccgccgtg aacacagtgg tatcagtcgg caaccttgaa ccgagaaaat gaaaacggtc
     4261 caacaggccc attgtggaca ttgaatgccc tgcattactt ggagttactt tgtagaccta
     4321 gtatgactgt aaagcgtaat aatgatcata attaccatga tgcatgtttt ttgtagctat
     4381 taattacatc cccaagatcc tagtgatacc ggcgatgaga aagaacagct gtactatgcg
     4441 acgatgaagc cacgaacttg caggtaccgg atcacggtct ggtagaatgc caggctacaa
     4501 tgatcattgt cccgatatgc atcggttatg cttgggaatg caacttgcgt gactttcctt
     4561 actaagaatg tgccgaaaag cgactattag cagctgacga agatccgact gaagtccagt
     4621 tcacgagcca atggttcaca cggcgtttta agactagtat attgggctaa tcagtctaga
     4681 acaccatctt acaagtagga atatcggagt gcgtgcaaat gcgcgcccgc taatctatga
     4741 caagaatgag aatctgagcc tcagcagact gagttactgc taactcaatt aggtgaacga
     4801 tcggagaacc agaagaactc tacggatttc gcccgcattg ggcttgatga tcttcactgc
     4861 atatctgcca agtcaatcat tcttcccgag cagcccatgc cttcacttcc taatcgagaa
     4921 cccgacgcct ggaagatccc gagggtatct cggaaaggca cccgaaggca tatgtacatt
     4981 gtaacttagg ccatacccgc ggacaggctg aatccagacc acaaaataag ttaaactaac
     5041 ttcggtttgg cgcatccgcg catcccagag atacagtgaa gccgaagacc aactgacagt
     5101 tgggccgtgg accacgggca accagccacc gcgggactgt aattataggc cacggtgttg
     5161 gacccagaaa taccgttacg gtctttacgg atatcatatt caagccggcc cggattcgaa
     5221 tgagctagtt aatgtattat tcatttcttc ttttccattg ataacattct ttccctttct
     5281 cttgagatgt gctgagtacg aagctgatat gagatgcatc tagggcacct gtggccacaa
     5341 cgagaaggat agtcaagtac aaagatgaca cgacaaactg accatactca aggttatcac
     5401 tacatcgtca ttctttccat gtcccatgtt tcacgaacgt catatcccaa tattatatcc
     5461 caatcagctg ctaacctttt ctgctggctt gcacctggat acacgcacca tgagtggtgg
     5521 cacttcccat gttgtccatg aacgatgacc tgcgagccag gggctagatt cattaactgc
     5581 aagttcacag tcaaactccg ttacaaattt gcagaatact atttttgtca tggcatatgc
     5641 catgctattt tacatatcag ttagacaatt tcatgcataa taggtattag gttcacttac
     5701 tcttgaccaa tacaaccccg cggacctgtg gaaaatggat gaaatgccgt tttattatct
     5761 ttctggtacg ggtcatctgc accatctagc cagcgatcag gaataaattt gtcagggctc
     5821 cagaagtggg tgggggaatg tgtggctgca aaaattggaa tatagacccg cgtgtttcct
     5881 gagacccatc gaccggctat gcgcgccccg cctgcagggg tagcacggtg taaagctcca
     5941 gggaccgagg gatacagcct taaagcctcc ttgatacagg catccaagta cgcgagattc
     6001 gacacagatt ccagagatac ctggctctta tcgtgaaatg ctgtgcgaat gtcatttttg
     6061 agacgcgcaa gacactcagg gtgctgaagg agatatgcag ttaaggctgt catgagcgct
     6121 gtggtcgttt ctgctcctcc agtcatcata atgtgggcgt tggcacggat gtctttttca
     6181 gtcaacgaca agctgcgact gttgcgaaat gcaaggccga taaggtctgg ttcgtcgctt
     6241 tgcaattgaa gccgacggtc tatgaggtca ttcgaaggct tgaagtaagc cttgcggagc
     6301 catttcgaca tccagggtat ggtcgaccgg aataaaaggt taatccagga gaattcagcg
     6361 agagctgata ataaagtcgc ggcacgtacc agcctgtgct ggctgtgtac ccacgattta
     6421 tgtgctcctg ttcgcaagac gcccaattcc tcgccaaagt gcaaatgccc aacgatgtca
     6481 aaaagcgtgt aatggaacat gttgcgtata tttgtgattt gcccttctat tccagaaagc
     6541 ctttcaacga gagcgtcgcc atacttggca aggattgatt cctggcgggc taaggctcgc
     6601 cgtgaaaatg ccggtacgta tgctcgacgg attcttgggt ggtctatttc attggccgca
     6661 agaatagagg gccgattgtc atcatcctca agatatctga aaaagtccga ccctctccgc
     6721 atactctgtg gctcagtggg agaactgcta tatatgtctt tccaggcttg tgggtcgata
     6781 aagctcagct cattcggagc aacacgtagg actggtccat atttgagatg aaggttatgg
     6841 agccactgtg tttgaatccc cttgagtgag gcataagtca cgggaatcct gctggcggcc
     6901 agcattcgcg ggccggggac ctctttcagt ggatgaatga acagattata agtaaccatt
     6961 gataggtact atagatcact ctcggtctta gttctctcaa tcactgaagt atcttctgaa
     7021 gaatagcagc ctttcataac tgaccagaaa aatccctgtt gccacaagaa tgcttgccac
     7081 gttttcttcc ggcatcttgg ctccgaagat atgtcgtgca aggccattta aatgtcgacg
     7141 gggagtgtta tatcaaatag aggaagtgag agaacaatgc agagtggtag attgacttgc
     7201 tcgtagaaaa gttatctcca ccaactattt tcagagtcga ataactgcat ctacacgagg
     7261 catgggaagt catcaaaagt cgatctacaa gtggtaagtt tttcaaacag gacgatccag
     7321 ggtgtgagta ggatgttcct gtgaccttgt gtaaccgacc tcattattcc ataaacccct
     7381 tacatcaacc accgctggaa ccataagagg catacatgat tattccatag ccaagggcta
     7441 tatattagca gaagaaatca ctgtctgctg ggtgagcaat aataatggtt cctctatctc
     7501 atgtcaaagc agccgcctcg ctatagccaa aaattcaaat cactcatatc ggttagtatc
     7561 ttgaagaaaa ccttgacaga agcaatgcac agagatggat tatcatagtg cccaaatagg
     7621 acggatgcag agctgtcaca caatgttcta tacctccttg aagcgagcac ctggatttcc
     7681 cttgctaact cggacagcac gacacttgct attagtcccc cggtcatttt caccgtcaaa
     7741 agatcaatac cctattgatg gtcttgtacg ctaattaggg tgtagtagca gaccggttga
     7801 gatacaaagc acacccatcc agagatcagc ctatactctt gcaagcttac aacattcctc
     7861 gacccacaag cacatcatac gtcgaggatg catatctgca aatccccacg gctgaacact
     7921 tgctgatctc tttcattctg agtagcttgt gcataagcca ttaacttgca cttaccgcgc
     7981 aaacatcatc tcatttgtct ataccattat tcatccatgt catctcacac aacatgacca
     8041 tccttgcatg cagatgtctc atggcaaact cacccatact ttttcgtcag tgtgacaaag
     8101 ctgtgcaaat gcctcttgct ccaatgtcaa cgccagtcat atcaacgata tgacgacatt
     8161 gactttctta tcaaagccac agacaccatt attgtccttg agaatgtgcg atgaatccga
     8221 tatggcaacc taatgacgta gtgaaatgtt ttttttgacg aacagctcca actacactca
     8281 tccgctttaa tagtaccttc ccaataccta gtacatccca caacaccata accattagca
     8341 cggtctgcaa caatgacaaa agcgcaaacc gcagtatcac ccgacgaatt cttcaaaatc
     8401 atcaccccct tcctaaacga aatcattccc aacatcccgc ccttcgcgcc cgacgaagca
     8461 ttctacaaag cagtcttcga caaattcgca gctgcctccg gcctcccaga agacagcatc
     8521 ccccacttcg tcggaacagg cgaagtccta gcacgatgct tctaccccag cctaccccga
     8581 gatctacaaa tatccatagg agtcttaaca gcatacgtct tctcaatcga cgatcaatgc
     8641 gcagaccccg agttccgcga gcagatcaaa tcgtaccgct cagtctttct cggccaatct
     8701 accacgaacc tccagtatat caagggtcta tacaataccc ttcacgatat agtcagtcac
     8761 tatgagtggt atgctggtga catgatcatc aaatcaacca tggacttcgt gagtatcaat
     8821 attgtggagg cggagcagac tggtgatttc atggtctctc catctaccaa gttgtttccg
     8881 gacttcttgc gacagaaaag tggtatcggt gaggcttatg cgttttttta tttccctggg
     8941 agtgattggg gtctggggga ttattttacg ttgatccccg atatagcggg tattattgag
     9001 cagttgaatg atgtgctgtc gttttataag gagtctgttc taggaaatga gcccggaacg
     9061 tgggttaagc agacttgtgt ctgtaagggg atttctgaag gtgaggcttt cagggagaga
     9121 gtggatcagt gcttaggcag tattcggaga ctgcgtgctg catctgaggg aaatccgaga
     9181 ctgctaaaga cagtcaatga gttcattaat gggtatcctc tcttccatct taacgcgggt
     9241 aggtataagc tggatcagtt tggcagttat catggttggc agggtgagaa gacggcgggt
     9301 gggaattgat agtataacag gccaacgcag ctggaaggga ttggaataag attgaactcg
     9361 ggtcaaagca tttaagacta agaatatact ggtgtcaaca acgtgaagag ggacgttcat
     9421 tgcaatttgg gggccatcac gattctatat actaaggcgg agcgagagtg acagggccgc
     9481 gttgctcaaa ctttcacagc acaatactag gatacctttc acaagactca aagagaggac
     9541 agtccattga tttcattact gatcacgagg tgtacgcaag tgtcacactt cctccaaaaa
     9601 gtattcgctt atttccaagc cgagtcctaa attaggtggg aaaaaggacc ctatgatctg
     9661 ccctgtgctt ggatcataag gaaggctctc atcgtaagta tcctgagcgg tggtatcctt
     9721 gtccgtatgc atgaggtcgg gactttctga agcaggctgg ccttttaaat gggcttccag
     9781 agaagttgac ggatctgaga gcggtagagg accacatcca agttcattag tctgcggctc
     9841 tggagcagac gaaagtccgg ttggtccagg tccaggcgta acagaagtgc cgaatctgct
     9901 agggatgggc gggttgggta aattcacgcc cgcatattgt tcgatacggc gcaaaagacc
     9961 ttcgcatagt aagcgagctt tctccgaggc cgcgttggta tttgcgagta tagcaagcca
    10021 tttaagtgct ctttcggtcg ccttagaaac catcgatgct ttctctggta cgtggcaaac
    10081 accaaaagac agttccatta aaaggaccgt ggttgcttgt acaagaaaat gcagtataca
    10141 ccaccaaggt gacattctgt acagcgcagc agcatctagc ccatctggga acaatctcag
    10201 catatggcaa gctgattcca cgcactcagc tgctgttctc tgacagaaat cctgtatctt
    10261 ttcatctgga gttttgccat cctgattcac aggattggga cggcgcagac atggccgtgt
    10321 tattccaatt ttggtgctat agaatataaa tgccaggctc attcggtggt tagatatcga
    10381 atgagtaacc tgcgtggatt gggtcgaggt aaagtcaaac tcattaggaa ggctcagaag
    10441 ccatgattcg atgtcagatg taagaccttg tatggcgaat tctatcccca tccaagacgt
    10501 gctcgctgct gagggactgt aaagcttagt tatcatcttc tttgatatca gcatgagccg
    10561 aatgacatgg aagaagtgca acgatccaga gggaggaccg gaaattgcgc ctgtaccctt
    10621 ggagattgct attgagtgtt tgcccatcaa atcaaaatct gtatgaattc cttcagttcc
    10681 gtgtgagaac cggaggcaat ttataacttc atccttcccg aaatcctttt cgtcaaatgg
    10741 tactggcaga ggtgttgtat agacagtatc atctatgaag gaaggccgtc ccgtgattat
    10801 gctaagtcgg tgatcaagcg tgtagagaga ccaccataca cgatatcgaa tctccctgga
    10861 agtatccgaa gcagacttgc tcatgttgcg cagatgcaac ccaagaccaa gggctccccg
    10921 aacagcactt ccacagattc tccaggcact tggtatattc gtaagcactc acatgaatag
    10981 ccgattcgta cctcccgaca tgatatacgt accggttgac atgccccaat gaaagcatgt
    11041 ataaagctgt tagcccttcc acttgtaatt gctgtaggtc aggatgatga aagctccaat
    11101 catctatact caagaccctc gctcttgaga aatacaacca gtgattattc ttgttcagct
    11161 gccattctgc ttcagagatg taagcatacc tagcagcaat cgcaaataat aggttcaaga
    11221 ctgcgagcca cttgttaccc gtatgtaacc tggtatcgtt gaagaatgcg tggaactgtt
    11281 ttccaaaagg tgtggttcct atgattggga aggtaggatg cacccaatcc aaatagcagt
    11341 tgtagagctt tgaagctaca tcctttgatg gtagtgcata tgcctcttgt cgctcgatat
    11401 ttggcagttc ttgatcatca acatggtaat tcgatgcgga gataggacta ctatcagaga
    11461 tcgataaaaa tatagcttcg ctcggagtac cgtgctcagt gtctccattg atatctcggc
    11521 ctaatgagtg tatccatgat atttcggagc tttgaccaat ataaccagta gcttgggaaa
    11581 tttcgtcctt gttgaagtct tcattgatgc aatcaaggca gtggcttgag tcaacatata
    11641 gtgacaactg ggaactggta gctgagagag gtctttgagt tccgggcaag ggggttcgcc
    11701 catcggggga caaggaagga ctagaggact cttcctactt ccggtcagta taaacactcg
    11761 aagagagagg acgaagagga tataacgggc tcaagaggat caaaggatat ggtttcaacg
    11821 agagcaaggc gaggggcctg tattcatacc acagtcaatg caaggttcat cagctgctca
    11881 ttcgtaatcc caaatctgct gctcaggttc ttcaaagcat cttcgtaagt ccgtattttg
    11941 gcctccaagc tagccaattg ccttggcgta ccaatttctc tgaagtcagc cacggagcca
    12001 tctaatcaga ttcagactca cctcttggat ttctcccttt taccatctgt atagcagcaa
    12061 atgatgccag cctcacggca gttgcgacaa ccggacttat ctccagtgca ctttgtcttt
    12121 ctctgtctgc aggattcaca tgctcggctc acgtggcgac gatgaaatct acctggagtt
    12181 gagaatgttt ccagcccttc tgctagccta ggaattgcca tcttcttgct agtcaaagga
    12241 tgctccgctc tgtgggagga caatgcatga gatgcactac ccttgagatc ctcagttaac
    12301 tttcggactg gtagatagac gagaggggga tcggatggcc ctcaccacat cgctgtagtt
    12361 gtgcgaaccg gtcgaggata tcctgaaggt cggttgttct ggccaagatg gatactgcat
    12421 tgtgctatga aggtctaagg aagaaagtcc acaattctgt ccaagcaatc attagtagct
    12481 gttctgtagc agcgccttag agagctcatc ttgatgtcac ccatcactga taccttagag
    12541 agttgaacaa ttgcaggatg atacaccaga gtaattgaga ggatgtcgat aacgtttaca
    12601 gaaaaggtag ctgagctgaa tcttaatata taattttaag actgagttct tcaacgaaag
    12661 tatagggatg taactcagcc cgaaagagag tgaaactagc tttgaaagag taacgtctca
    12721 cggttcatca aaaatcgaac cctcgatcag tttcttcccc ccaacaagat ttcttttggt
    12781 gaaaagtgca ggcggaaagc gcagtcgtgg ctacttccct tgtgtctctt gtttccctcc
    12841 agccgaggat cggcccgtct ctgagtctag atgctaggta ccaaattatc aaccagaaaa
    12901 gcgagaactc taggagacca ggtattaggg agaccagaat tgccgctgat ttccatggat
    12961 atgaaatggt agagtgctac cagctccgga aaatgcaggg aatgtagacg gattattcac
    13021 catgattagc cagccgctca ctgagtaccg tttgcttcaa gcgtaaccgc aacattttct
    13081 ttgactggct agacggcagt gttatgagag agggttgagg gcttgacaca aggttaaatc
    13141 tggaccagtt catcgttgta tttaggcagg atatggagta cgtgatgggc ccacgaggat
    13201 acttccatca tcttcgttgg ggccaagcta aacaatgtgc tcatagtgat tagctccttt
    13261 gggcgaacca cggtcgacat cagcagagtc tgtactgcat gtaacgttct cagagtttct
    13321 ccgtcatgtg cctgccagcc tagcggaaat cctggataat ggcccagagg attaaacttt
    13381 gccctgcgca actaatacgc atacagaata aattttccac tccatgaaga atatttaggt
    13441 gcctattcgg acccgaccag ccgaatatat ccctgtatcc gggtcaccct cttcgtagtc
    13501 ggttatttgc agcggcttaa ggtgatagtt tactgatcca agaacattcg cgtgtacacc
    13561 atcaaaatat ctgttatttc tagaaaaaac tgacactacc attcgaaaac agattgatga
    13621 taagtgagtc aaaattcaat aaataaaaaa aaaacacaaa gctttgttat catgaatcgt
    13681 acatataatg tggcccgatg gctttgtttt aacatgcgta gtggatgata actattactc
    13741 gagcagatga attatagttc aaagtacgta ttgagtgaaa catagattct tttcaaatta
    13801 acagacaata gatgaaatga tctttagaat tccttacaat tgtccactgg atggacgaga
    13861 ctggagttgc agaatgcggt agcgggccag gacaacagac actgccataa gcccctccca
    13921 ggcagatata ttgagtatcg tgttagtcat agtctaatgt attcaggacg aaggtgcacc
    13981 atctgtgata ctgtgacaag cgatttcacc atagcatcct gatcgattca cggagtagcc
    14041 tgatagtcca tctccgtagc ctttcagcca taaggaaatt tcatcggctg tgtgcaaact
    14101 tgagcaggag atttataggg ataatatggt cctacgttac actcctaact taaaatcgaa
    14161 tcactcatta gttgatcggt accctccaca tttaccttgt caattgccac agtatcatgc
    14221 cactttccgt gtcgaatatg ttacctaaag ccttaggcct gatccacggt acaagggctg
    14281 gactagaggc tcatgttctg cagcctgatt acacataacg agaataatga aataagtttg
    14341 tagttttatt atctccagat tggaccccca ccattttact cttaaccaat gcatcggtga
    14401 tatccaccga acagaattac atctgaagtg atactgatga agaaagctgg cccagacagg
    14461 cgttgattgc tttggccagg ttgtggtttc gtgaagcagg aattagtggt ggtggtggag
    14521 gacatagagc aggcgttgtc ctgtatacca atttcgcaaa ccggtgcaaa ttctcaggaa
    14581 tcggtcatat tggactgtgg ggaatatgaa tgactttgac tgctgtaata gacgccttga
    14641 ggctcgatga ggcagtctgg ttgctggaag tgatataaac agagaataag gctacagtga
    14701 agaaccatgc agccttggct ttgcccgtta aattatcttg agtcacagaa ctcgcacatt
    14761 ttctttcacg gcacgtcccg ctttcacgct gcttggttgt gtgtgctaca ataggtatat
    14821 aaatccctgc ttccctcgct tttctctgtc tatccaatct tccttctcat cacatctgaa
    14881 gttctgcagc ctcttagtca ccgaaacgca tgttacgtat ttgatcccta cagtccgata
    14941 ggttataata aagcgaccta tatacccgtt gatgtctcta ccacattgtg tacaatggaa
    15001 agtggtgtac ccccaaagct tcatgactct cacgacacat cgaaatgctc tacgtatcac
    15061 tttggatatg agactataac tgacccatgc tgaacatata cggcagatcc tcctctggcc
    15121 cgaagaatgg gattccatga cgctatgcct cgtacgaaga gagccatcgg cgcatccacc
    15181 gcaagctgaa ggacagatga actagaaacc ttaagagcat acataagaga ttctcctcag
    15241 gctcagcgat atcaatgagt tctgagcttt ggaatgattg agtcacttct tggggttgcg
    15301 ttcggcacgt atatataatc ggaactggat tataggtagt acctaattca cgacgtcatg
    15361 gaaattcacg cggctgttct tcagttgagg atgactggct gttgcatatg agcgtgggta
    15421 aaggagcatt ctccacctcg ctgaagacag ctttagaact cgcgaagctc ctatgcgcaa
    15481 tcatgaccac ttgggcattc gagattttta agtgttgccc tcatctcagt gttggcagac
    15541 taagctacgg tccgctgctc ttgaggacgc aggagcatct tgtgcgctgc gaatctgtac
    15601 tttccatcgg gatcccttcc gggggtgtca tggtagttta atgcgacaga gcttgccaga
    15661 caaccgaaat ccatgaatgc agtctcaata tgcacacttc aacatttcac gctcgcacaa
    15721 atgcttttac gagccatggc tgctacaagt attgaaagat acatcaaaaa ggaaaagcac
    15781 aacgacttcc tcacaattca gagattgagg attttcgtgt acccagcacg gagcaagcat
    15841 gccataccgg ctgatcactc ccatgcccac gacagctatg gactgcacgc cagtctgagt
    15901 actgctggtg tcttcgccga tagaaaagac aaataaacag cgaatcgcaa ggcaacgaag
    15961 gatatgtctc acgggttctc tgagaaatga tagtctcatc acgcaattac gtctccacca
    16021 gtcccgaagc ccaggtccac cggcgcctgc ggatggaagt agcatacaaa catctctaga
    16081 ccttttcatt atcatgaatc gattcttaat attgtactgt gaaagctgca tggttagctc
    16141 atttcaacag tgcagtctct atcaggttgt atagtgtgaa ctgggctgat gggattgaag
    16201 aacatgaata aattctgaac ttgggcgagc tatcggctca ttcccatttg tttagctttg
    16261 cgttattgta tatgttttct ttggcgggtt taagcttatt aacgatattc ttctccttcc
    16321 gatggtgaag gacctgatgg ctaacacctg tgtaacagaa ataatgagct ggaagactac
    16381 gaatttcatt gggtaagttt tggagctttt cttcatctcg aagattgcct ctctattaac
    16441 aacttgtagc aaccggaaat ggcactgtga tatggcctcc ttccctacgg agatatgcgt
    16501 atgttcaata ccgaaggttg cttcaccgac gcaatgatat cagactagcc ttcgacatag
    16561 gaggatgact gctatgggca ttcaatgtcg atttcctact gctgttagtc tatctccaag
    16621 cgtagctttt gctatgacaa aactggacta gtatacagtt aaaggttgac ttctgtgtct
    16681 tctatacctg tcattgacag acccattcag ctatccggca caactagaag gagcgtaaaa
    16741 gccaagtaaa acgatattta ggaaatgggc gagtacgtcc tagtaattta ggggaataaa
    16801 atccagaaac atccacatcg ggcattacat agaaactgca gggtgtgatt caacgcgatg
    16861 taaccacaag catgcaggct gcatcaatat tgtgatctgc gggatagaga tcttccgata
    16921 tcaatgaaag gtccgacaga gcgtcgtgaa gaccttcgta ctgctattgg agattatgga
    16981 tcctgacctc ttcgacggag taggcaaagg taatatagga ttccatccaa gaagagcaca
    17041 acaggagccg tcttggaatg ccaagccagt cgcaagattt aatggctatg gcatgtcaac
    17101 gccattagcc atccccttcc atagaataaa accgcgaaag atgcaatctt cattctggta
    17161 gcttccggca acataaagac gaagcgagcg atctcaggag aagcattcca gctttgtaca
    17221 tttgctgttg ccaaattttg tggcctaatt aaccaaatga cttctatttc tgctggtgac
    17281 gataccacta cgctgcttcc tggcaggaac cgaagtgacc agtatagcct gcgaagtcaa
    17341 tatgtcatca atttctatat taagcctatg tgaatcaaag tgacccatgg atgggaagaa
    17401 aaatccgagt tcaagaacta tatcgtctat tcttagtttc taatgttctg attgctgagt
    17461 atctcttcta caaccctcaa cattatattc aagttttatc atttgaacac tcctacccta
    17521 ttatctacca gtttactagc aagcttccta cctttggaaa ctccgctgga gaccatacca
    17581 tcgctaccaa aattccgccc gaaacatctc agacaccgac ttccctcaaa agctcctctg
    17641 cataggcgac tctattcacc ctctgccctg tcaaccaaat cttcagtacc catcttaacc
    17701 atctataaga tggctcctat cctcctctcc aacaatatcc gtactccctt cagatacttg
    17761 aatcgcatca tccaccttcg caagggcgag gacaagggca aaaccagagc ccagcccgat
    17821 ctatcatcag ccctaacccg actcttcgcc aactctgaga atgacgatga ggaatcgtct
    17881 atcacccaca tcacggagtc tacttcccag atatgggtcg aagaccaaga tccagccctc
    17941 gttgacttac tcgccacact ctcctttacc ataacgacca gcacatccga cagctctacg
    18001 cttcttgcac ttcttgcttc tgccctcgac atcctatcca cctacgctca aaatcacaaa
    18061 gtcaatactc ttccaatcta taccgccctc ttgcgtcatc tagacaccta taccagctat
    18121 ctcatctggg atcatgagat ccttcttaca gatgcagaaa ttatctttac cgcctccagt
    18181 attccaaccc ctaaacaccg ggacaacatc atcctccagc tggaatccgc atatgtctcg
    18241 aactacgaga cgtgcaagac gctagtaact cgtcttaatc aactagttga tatagagctg
    18301 atggaacgtg cggattggat atttcctcgc caaattggct gggtagaagt aaggagagaa
    18361 gttataaggc ttgaaaagac tctgaaagaa atcagatggg ctggcaagtt gaaagaagtt
    18421 gaatacgtca attgctaa
//
