LOCUS       ACJE01000021.1         18249 bp    DNA     linear   PLN 19-AUG-2019
DEFINITION  Aspergillus niger.
ACCESSION   ACJE01000021
VERSION     ACJE01000021.1
KEYWORDS    .
SOURCE      Aspergillus niger
  ORGANISM  Aspergillus niger
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Eurotiomycetes; Eurotiomycetidae; Eurotiales; Aspergillaceae;
            Aspergillus.
COMMENT     'Annotated using funannotate v1.6.0-df4262f'.
            ##antiSMASH-Data-START##
            Version      :: 5.0.0
            Run date     :: 2020-11-02 06:16:28
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: <1454372
            Orig. end    :: >1472621
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    <1..>18249
                     /aStool="rule-based-clusters"
                     /contig_edge="False"
                     /core_location="join{[1464225:>1464512](-),
                     [<1463411:1464159](-)}"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(join(<9040..9787,9854..>10140))
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     cand_cluster    <1..>18249
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     region          <1..>18249
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="5"
                     /rules="(Terpene_synth or Terpene_synth_C or phytoene_synt
                     or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps
                     or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /tool="antismash"
     mRNA            join(<1..159,265..>1143)
                     /locus_tag="ASPNIDRAFT_47481"
                     /product="hypothetical protein"
     gene            <1..>1143
                     /locus_tag="ASPNIDRAFT_47481"
     CDS             join(<1..159,265..>1143)
                     /codon_start=1
                     /db_xref="PFAM:PF09753"
                     /locus_tag="ASPNIDRAFT_47481"
                     /note="EggNog:ENOG41"
                     /product="hypothetical protein"
                     /protein_id="ncbi_ASPNIDRAFT_47481-T1"
                     /transl_table=1
                     /translation="MTLTDYASYPDSPDLAALNLSRLVARLEHNLLSSAADLKPLRRSE
                     YQRMRVGANIEYARTNLQTLERTLPQIKPTDRRNDLQTDLARQRQILKQLQIVLDEISS
                     SQAEPQSDEEEEDDSLDGEDLLDTPEEGSTTDEQFEHEEKERDTITDDHEPATTAPTST
                     LPAPTTATTTTELPSQTPEATPAPTQEQPSTLRNRSHAPTTTPSTATASATGSSIQKNP
                     PSPQQSSDASSDARLQATEETLSSHRAEQENLTSSMLALATQLKTSAQTFHSSLEAEKS
                     VLARAVDGIDRTAGNMKVAEQRMGMLRRMTEGKGWWGRMMLYAWIFGMWVVAILIVFLG
                     PKLRF"
     mRNA            complement(join(1744..2161,2221..2777,2835..3177,
                     3253..3481,3837..4298))
                     /locus_tag="ASPNIDRAFT_208006"
                     /product="hypothetical protein"
     gene            complement(1744..4298)
                     /locus_tag="ASPNIDRAFT_208006"
     CDS             complement(join(2118..2161,2221..2777,2835..3177,
                     3253..3370))
                     /codon_start=1
                     /db_xref="PFAM:PF00025"
                     /db_xref="PFAM:PF00503"
                     /locus_tag="ASPNIDRAFT_208006"
                     /product="hypothetical protein"
                     /protein_id="ncbi_ASPNIDRAFT_208006-T1"
                     /transl_table=1
                     /translation="MGCGMSTEDKEGKARNEEIENQLKRDKMMQRNEIKMLLLGAGESG
                     KSTILKQMKLIHEGSYSRDERESFKEIIYSNTVQSMRVILEAMESLELPLEDARNEYHV
                     QTVFMQPAQIEGDNLPPEVGNAIGALWRDSGVQECFKRSREYQLNDSAKYYFDAIDRIA
                     QPDYLPTDQDVLRSRVKTTGITETTFIIGDLTYRMFDVGGQRSERKKWIHCFENVTTIL
                     FLVAISEYDQLLFEDETVNRMQEALTLFDSICNSRWFVKTSIILFLNKIDRFKEKLPVS
                     PMKNYFPDYEGGADYAAACDYILNRFVSLNQAEQKQIYTHFTCATDTTQIRFVMAAVND
                     IIIQENLRLCGLI"
     mRNA            join(<7519..7555,7619..7719,7809..8059,8154..>8568)
                     /locus_tag="ASPNIDRAFT_47479"
                     /product="hypothetical protein"
     gene            <7519..>8568
                     /locus_tag="ASPNIDRAFT_47479"
     CDS             join(<7519..7555,7619..7719,7809..8059,8154..>8568)
                     /codon_start=1
                     /db_xref="PFAM:PF01713"
                     /db_xref="PFAM:PF08590"
                     /locus_tag="ASPNIDRAFT_47479"
                     /note="EggNog:ENOG41"
                     /product="hypothetical protein"
                     /protein_id="ncbi_ASPNIDRAFT_47479-T1"
                     /transl_table=1
                     /translation="MHEHEMSYMGPRAFSHDQSQDAEAEYDRLRNLARQEASKRNSCFQ
                     RSQEAYSSGDGAKAKELSEQGKAHGRKMEEYNKQASEFIFRENNANGRVAADTIDLHGQ
                     FVEEAEEILEERIKYAKAHGQDHLHVIVGKGNHSANHIQKIKPRVEQVCQELGLQYATE
                     ENAGRIYVNLTGGPADMETAPTPNHPHYQQYPQHQQHPSGTYAHPHQQQQQQYPGSQQQ
                     QQQQQQQQQQQQQQGAGNQDEIEQVVNAVLPKILNKLEKACCVVM"
     mRNA            complement(join(<9040..9787,9854..>10140))
                     /gene="AL3"
                     /locus_tag="ASPNIDRAFT_38226"
                     /product="farnesyltranstransferase"
     gene            complement(<9040..>10140)
                     /gene="AL3"
                     /locus_tag="ASPNIDRAFT_38226"
     CDS             complement(join(<9040..9787,9854..>10140))
                     /codon_start=1
                     /db_xref="PFAM:PF00348"
                     /gene="AL3"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: fung_ggpps2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: fung_ggpps"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182:Polyprenyl synthetase (Score: 240; E-value:
                     5e-73)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ASPNIDRAFT_38226"
                     /product="farnesyltranstransferase"
                     /protein_id="ncbi_ASPNIDRAFT_38226-T1"
                     /sec_met_domain="fung_ggpps (E-value: 7.2e-154, bitscore:
                     506.5, seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="fung_ggpps2 (E-value: 1.5e-97, bitscore:
                     321.5, seeds: 17, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MDHTGPDEDGLPTNTNHSRMHNRNRSSVDGTKYKDGQWSPDNERI
                     VLGPYDYMLQHPGKDIRRQLINAFNVWLKVPPESLSIITKVVAMLHTASLLIDDVEDNS
                     ILRRGIPVAHNIYGTAQTINSANYVYFLALQEVQKLNNPAAIDIYVQELLNLHRGQGMD
                     LFWRDTLTCPSEDEYLEMVGNKTGGLFRLAVKLMQAESSSGKDCVSLVNVMGLIFQICD
                     DYLNLSNTTYTKNKGLCEDLTEGKFSFPIIHSIRSNPGNHQLLSILKQKTKDDEVKLYA
                     VSYMESTGSFAHTRDVVRELRAKALTLIQAIDGDQADGREDGAMVRAILNKITESTLGE
                     CGPQ"
     mRNA            join(11451..11799,11864..12781)
                     /locus_tag="ASPNIDRAFT_198494"
                     /product="hypothetical protein"
     gene            11451..12781
                     /locus_tag="ASPNIDRAFT_198494"
     CDS             join(11544..11799,11864..12498)
                     /codon_start=1
                     /db_xref="PFAM:PF08045"
                     /locus_tag="ASPNIDRAFT_198494"
                     /note="EggNog:ENOG41"
                     /product="hypothetical protein"
                     /protein_id="ncbi_ASPNIDRAFT_198494-T1"
                     /transl_table=1
                     /translation="MEALLAHSFDYLSSYEPSKVRKGLRQVEGLLAQICLSKTKRPSSD
                     KRRSLLSFGAPQPVPKSLAELRDDPAFREFFKLQEGFQWNVAMRLVTCLEHLLGRGSNG
                     TNDLLIVSTLDLIQGVLLLHPPSRTLFTREIYMNLLLDLLDPINCPAIQSATLLTLVTA
                     LLDHPANTRTFEELDGLLTVTSLFKQRATSREVKLKLVEFLYFYLMPETPMIPTSAASA
                     PNTAVLGHQRSPSKLGVSPVSRSVNVPGAHGGGKAHRDTRTTDEKQALLGRYLNNVEDL
                     VEDLKETAPFGATVY"
     mRNA            complement(join(<13060..13343,13418..13623,13663..14035,
                     14137..14227,14289..14685,14751..>14971))
                     /locus_tag="ASPNIDRAFT_38224"
                     /product="hypothetical protein"
     gene            complement(<13060..>14971)
                     /locus_tag="ASPNIDRAFT_38224"
     CDS             complement(join(<13060..13343,13418..13623,13663..14035,
                     14137..14227,14289..14685,14751..>14971))
                     /codon_start=1
                     /db_xref="PFAM:PF01565"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1138:FAD linked oxidase domain protein (Score: 218.8;
                     E-value: 3.2e-66)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ASPNIDRAFT_38224"
                     /note="CAZy:AA7; EggNog:ENOG41"
                     /product="hypothetical protein"
                     /protein_id="ncbi_ASPNIDRAFT_38224-T1"
                     /transl_table=1
                     /translation="MAEVVAEIVANACHLEQEKATHIETLLSRFDSLSAAEQDQERASY
                     VAAVFPLFFGAAAVVHGSNGYEPQRIVPWSTNCWLQPRVIVRPGSAQQVAAALALCRFF
                     HVKFSIRGGGHLQIPGFTSNQDGVVISLGAFDQVRVAEDKSTAEIGVGLRWLEVYRALE
                     EHGVAVAGGRVPTVGVSGLLLGGGISFQNSQYGVGAMGVCNYEVVLANSQIINANAREN
                     SDLFWALKGGGPNFGIVTKIEMNTIPNQIWTEVRIYPLTAADQLRAALMQYHEAIETDN
                     RASLIWNATNDIILIVYFYCAPVENPPVFQAFYDIPFLTSFVPPGIRTVYDLVQAVASV
                     NEAEPTVYAIYPPFTCSKHENHEFRTMSSRPSLEVYKAIEQAHAEQAEALKDVEGIALT
                     TVIQPMSSLAMRETLKNGGTPLGLEPVGQQWFLARADWKNIQDEDRVREAVRKIVDAAE
                     SAAKQTGVYLPYKYSNYAAWDQDPLASYGGENVRRLKEVARKYDPEGVFQTLQNGGWLL
                     SRVGLE"
     mRNA            join(<15316..15375,15570..15635,15688..15792,15840..16114,
                     16141..>16222)
                     /locus_tag="ASPNIDRAFT_38223"
                     /product="hypothetical protein"
     gene            <15316..>16222
                     /locus_tag="ASPNIDRAFT_38223"
     CDS             join(<15316..15375,15570..15635,15688..15792,15840..16114,
                     16141..>16222)
                     /codon_start=1
                     /locus_tag="ASPNIDRAFT_38223"
                     /note="EggNog:ENOG41"
                     /product="hypothetical protein"
                     /protein_id="ncbi_ASPNIDRAFT_38223-T1"
                     /transl_table=1
                     /translation="MALPDFAFSSLSILMTTSALLYLRKFVLNNFGLDDWLVLVALIGV
                     DLFSALAYIITYYGLGRPMKYVPTDHLVVFLTLEYASQCAYLVIAATVKASLLIFIMRL
                     FPTRFVHIAGKALLGIIAAFTLSGTLALVFQCRPVQAAYDKAITNSSCYPTETSYAILM
                     MQGVIITSDMAYLAVADADKEANTCAGAALHW"
     mRNA            complement(join(<17201..17596,17673..17912,17992..>18249))
                     /locus_tag="ASPNIDRAFT_38222"
                     /product="hypothetical protein"
     gene            complement(<17201..>18249)
                     /locus_tag="ASPNIDRAFT_38222"
     CDS             complement(join(<17201..17596,17673..17912,17992..>18249))
                     /codon_start=1
                     /db_xref="PFAM:PF10568"
                     /db_xref="PFAM:PF17171"
                     /db_xref="PFAM:PF17172"
                     /locus_tag="ASPNIDRAFT_38222"
                     /product="hypothetical protein"
                     /protein_id="ncbi_ASPNIDRAFT_38222-T1"
                     /transl_table=1
                     /translation="MTPEYRDDPGQTPDNVSTVSRARDFFSVPTPIKRIFDRFPLVTYP
                     SNDLPHSAWSDKRGNRLYVFTDAASARHGRPSFNPQCLKWQAYLRFVGIDVDVIPSNNH
                     ASPSGALPFLIPAHPINNNAPIPSSKLQKWAIEQVHCEEEQQLDLRFEVYASLLDHRIR
                     NAWLYTLYLDPEEFEAVARPLYVNPSSTNSAVRTALALQLQQAARTEILKTSSYIDVGA
                     LEAEANDAFEALSTLLGDNQHFFDRPNPGLFDASVFAYTHLILEEKLGWRRNRLGQLLR
                     QHENLVQHRDRLLKFF"
ORIGIN
        1 atgactctca cagactacgc ctcatacccg gactctccgg atctcgctgc tttgaacctc
       61 tcgcgccttg ttgctcgttt agagcataat ctcctctctt cagccgcgga tctgaagcca
      121 ctacgccggt cagaatacca gcgcatgaga gtcggagcag tacgtcctcg cgcctttcct
      181 ttacccgaca ttatccatcg cgttgcatcg tggggaacac agctacagcc agcatcttga
      241 cttttgacta accttccacc aaagaacata gaatacgccc gcaccaacct ccaaaccctc
      301 gaacgcaccc ttccccagat caagcccacc gaccgtcgca atgacctgca gaccgacctc
      361 gcacgccaac ggcagatcct caaacagctc cagattgtcc tcgacgagat cagtagttcc
      421 caggcggaac ctcaatccga cgaagaagag gaagacgact ccctagacgg tgaagacctc
      481 ctcgataccc cagaggaggg aagcaccacc gacgaacaat tcgaacatga agagaaggag
      541 cgtgatacca taacggacga ccatgaacca gcaacaacag cacccaccag taccttaccc
      601 gcaccaacaa cagcaacaac aacgaccgaa ctaccttcac aaaccccaga agcaactccc
      661 gccccgacac aggaacaacc atcaactctc cgaaacagat cacatgcacc cactaccact
      721 ccctccactg caacagccag cgcaaccggc tcctctatcc agaagaaccc tccttcccca
      781 cagcaatcct cagacgcatc ctcagacgct cgattacaag cgacagaaga gacgctctcc
      841 tcccatcgcg cagaacaaga aaacttgaca tcatctatgc ttgcgctagc aacgcagctg
      901 aagacctcag cgcagacatt ccactcctcc ctggaggcgg agaagtcggt gctggctcgc
      961 gcggtggatg ggattgatcg cacggcgggg aatatgaagg ttgcggagca gcgtatgggg
     1021 atgttgcgga ggatgacgga ggggaagggc tggtggggac ggatgatgct gtatgcgtgg
     1081 atcttcggga tgtgggtggt ggctattctg atcgtgttct tggggccgaa gctgcggttc
     1141 tgattttgat gggaggcgta ggtgtcctcc atcggggagg gagtgccaag taacagtagt
     1201 agatagcact atccgctggg cggagattga agctgaacct gggtctagtc ctagacacct
     1261 tgtgtagata catgctgata attgataaac tattcctatc ttgtgcagat atttatttaa
     1321 cggatcaagc atttattcta aaagttcttc cattgtacac cgactctacg cggaaacacg
     1381 aattctttta acagaagata tatttcacaa tcctttaact ctgactataa cccaatgacc
     1441 gacccggcat gacacatgag aaaatgacat gaatatcagc gtaccctgtc aatctcccgt
     1501 gcccgtggcc ttgtcgtcgt tcattgccct ccaatgtacg tgagaccaat atggaagaat
     1561 gcgtgatata tggttacaca cagaattgcg gacgaggggc accaagagat gatgggatat
     1621 ccagctgggg aaaagaagac acaggataga aaaggaaaag cggaaagggg gggtggaggg
     1681 taacgcgaac acggagggag gtagaccaga aaacgacgcg ggaatcccat ataagtgaaa
     1741 agggaaaaag aagacacgca agcacgggct ctaattatct atgaattccg atggaaccac
     1801 agatgacccg ctgctcacag agaagagaaa cagaatggaa agtgcaaagg taaaacaact
     1861 cctgctctgt gtcatgggat ggatatcggt aatgctgata acaaagagcc ggctagatat
     1921 catttcaaga caaaggaaat agggaattag taaaatagac aagtgaatgt ctcaacgcca
     1981 ggatctctca aaagggagga aaaaaaagaa cagattgcga catggtatgg caaaaagcaa
     2041 aacagacaag attacaagtc acatagcata cggtctaaat gtcgagaagt tctcactcga
     2101 gcgaaatata ccggtcatta gatcagacca cacagtctca ggttttcttg gatgatgatg
     2161 tctagaggaa gtcagtatct ggaagcacgg aaccattcaa aaggggcatg caaaacatac
     2221 cgttaactgc ggccataacg aaacggatct gtgtggtatc cgtagcacat gtgaagtgag
     2281 tgtaaatctg cttctgctcg gcttggttga gagagacaaa gcggttgagg atgtagtcgc
     2341 aggcggcggc gtagtcagca ccaccctcgt agtcggggaa gtagttcttc atcgggctga
     2401 cgggcagctt ctccttgaaa cgatcgatct tgttcaggaa gagaatgatg gaagtcttga
     2461 caaaccaccg ggagttgcag atggagtcga acaaggtaag agcttcctgc atacggttga
     2521 cagtctcgtc ctcgaacaac agctggtcgt attcggagat ggcgaccagg aaaaggatgg
     2581 tagtgacgtt ctcgaagcag tggatccact tcttacgttc cgaacgctga ccaccaacgt
     2641 cgaacatacg gtaggtcaga tcgccgatga tgaaagtagt ctcggtgata ccggtggtct
     2701 tgacacgaga gcggaggaca tcctggtcgg tggggaggta atcgggctgc gcgatacggt
     2761 cgatggcatc gaagtagcta aggaatcggt taacaaaggc tcccgacgag cccgagacag
     2821 acgcgggcac ttactacttg gcggaatcgt tcagctggta ttcacgagac cgcttgaagc
     2881 actcctgcac accgctgtcg cgccacagag cgccaatggc attgccgacc tccgggggca
     2941 ggttgtcgcc ttcgatctga gcaggctgca tgaagacggt ctgcacgtgg tactcattgc
     3001 gagcatcctc cagaggcagc tccagcgact ccatagcctc caagatgacg cgcatagact
     3061 ggacggtgtt gctgtagatg atttccttga aggactcgcg ctcatcgcgg gagtagctgc
     3121 cctcatggat cagcttcatc tgcttgagga tggtcgattt tccggactct ccagcacctg
     3181 tttcaagaca tcgttagtct tgcgtcccag cgaaggcact gcgaaacatg cacggggaga
     3241 ggaggcgcat acccagcaac aacatcttga tctcgttccg ctgcatcatc ttgtcccgct
     3301 tgagctggtt ctcaatctcc tcgttgcggg ccttgccctc cttgtcttcg gtactcattc
     3361 cacaacccat tttggcggct attaatgaac gtgggagtga tggatgaaaa agtctaaatg
     3421 tgtagcgggg gtggaaaagg agtaggtggg cgggtggtag tgaacgtcaa gagtaacgag
     3481 cctgtccgca gggaaagatg tcagtcagcc atgggaagcg aattctccgt gtattgtaaa
     3541 attggatttc aaccagcccc ttgccccgtc gaccgtgggc gaacgcggaa agaaccacaa
     3601 tcggacaccc caagaaaaac aatcgaatga acgatgcacg atttgatttt tgagtgtcgg
     3661 aaaaggatca gaaccaaaag ccagcagtct ccccagagat cgtgctgacg caaggaggtg
     3721 cagctgatgc gtcaaccgga aggcttggga gcaccgttca ccatgaggga gggattccgg
     3781 ggcacagagg aagcgcaaag aggaaaagga acaacgacgt gaaaggggcc actcactttg
     3841 ctcgagaact tgatatatca aactccaact ggggaggagg agaaagagaa gaatggaatt
     3901 aaaccgggga tgatattatt actaaaggcc aagcggacgc aaaggaacgg gcggcagggg
     3961 aaaaatcaaa tataagcgcg gagcgtctgg gactagtagg cggaaaggag gcgaaaggaa
     4021 ggtggaacag cgaaatacac caatcgcggt gatttcagca aggataatcc agagaagttg
     4081 gatggaagag gatagcgaaa ggagaagtag taagtaaata atagagaaaa gaattggatg
     4141 aaaaagtaaa cccagggatt cttcggggag atgttggttc tatcccgatc cgtttgagaa
     4201 agttggggtt tgaaaggagg agaaggaaga agaagaggaa gagggagggg gtgggtggtg
     4261 ggaatagatg agacaagaga tcgaaaggga aaagaaaaga gagagagaga gagagagtaa
     4321 agcgagcgag gctgaagggc cggagggaaa ggattaagct caacaggttg taaggggggg
     4381 cagactttca gcgtgagtga gtcgggcaac ggaaaaagag gggccaagac gagatcctga
     4441 ggcagtcccg agagcgtgcc aaaaaagacg agtaagagag cgtgtgagag tgtgagggag
     4501 agagactacg acgaactagc ctggagagca gacagacccg ggaaaaggag ggactgattg
     4561 ggggaaaacc tgaggaagag gggattaact aaagagaacg cagcaggctg atacgccgac
     4621 tccatcacta ccgggtgccg gtacctgctg ctgctagtct actagtaaac taagtaggta
     4681 ttctagtacc aagtgagtat tggggggggg gggtgtgggt gaaggctgag gaaaaggttt
     4741 ttcctcttct ttttcgattt cgattttgat tttccctaat aaaattttta taaaactttt
     4801 ttttttaccc ttttcttttt ctcctccttc ttctttctgc cattgaccat tcccgctttt
     4861 ttctggaacg ataagctgac ccggttccaa cctatgagtg acgataactg gaccacttca
     4921 ataggggcag tggagtcgtc tcgtttggta aaggcgatgg cgacccagtc tttggtttct
     4981 gattggctct gctggtaagg ggtggcagtg gaggaaaaat ccagcacgat ccaatggaat
     5041 tgcgatttta atgagtagct ctcccctttt tcgacgtccg gctcttcttc tactttgtac
     5101 caagtttgtg gtgctccaac ttggattctt ctcccgatgg taagaccagg gcaattcgaa
     5161 aagggcatag cctcttacat cttaaatccg aaaagcccat cctagacaca cctatgacta
     5221 ttactaccac accatcctct actaactgga tactgcgtta tagatactgc atgtcggtag
     5281 cataaggcat gatccagcaa actatgagac atgaaagagg ttcaaagtta aatcccatat
     5341 agagtggcaa tcttcttcca aagttgtcgt tgccgtagat ataatgatta atgattcagt
     5401 tgcatgaatt aatttccgga tgacgcagat ctgcagtgcg cacctgtagg agatggccat
     5461 ggcgaccggg atgccattcg acagcccatc aggtgttgtt tttaaactct tcaaatcatg
     5521 ttaagcgctg acctccactg gtgacgaaat caatcccaga tctctcttgt ctctgctgct
     5581 catcagtaac ggactagact aatcctgcag cagtaataac aaccacagca gcagcaggag
     5641 ccgcagaaga catcgtcaac agttcgtagt agccgaccgt ttctaaacct ggtaaagggt
     5701 gcaagctgga agggcgcctg cagtttcagg tgcccaccac gcggtggagg cccggcacgc
     5761 tcagcgcccg atcgccaggt acaccgcgcc atcatggctg gcttttccat cacacaaagt
     5821 tacgcggtcg gttggcttgt tccagaatgt cttgggggct tgagttggaa aaagagacag
     5881 tgacgcttta ctcgtagtgt ctattcatag accggacatt ctgaggaatc aaacgtggcg
     5941 gtatcgtgca tgtctgatgt gatgatatac ggggtagaat gcaaccagcg gaggctacta
     6001 ctgcagctct accatgtgga aaaggtggat ggcctcaaga ttgggatggg cattagcgta
     6061 cggaggaata ttgtcgttcc tgttcctacg gccaggtact gtatggtaaa actccacttg
     6121 caactgcccg tcgatcgctt ctccgcacaa aagggagaaa aatggatagg gagatgagaa
     6181 tcatgcattc acaaagaccc attcgctgct cacccatatc ttctgagttc tgatacacgc
     6241 ttgtggtttc gcccagtggc aacatcgaaa tccaatatgt actccttcag tcgcatcatc
     6301 tcatgctgtg acaacgtctc ccatggataa aagaaggatt cagcgacttg tctcccacaa
     6361 ccaccgggca tgcacaggcg gaacgacccg cctgaatcgt gcaagatgga atctgctcag
     6421 atattgcttg ctggaatgga ggtcggtaac cgaaatccgt ggttctgcca ctcgactaga
     6481 gaccaacttc tccactgtct agtcgccttt agtcgcttgc ttttaccgcc cgcgctattc
     6541 atgatgattg tcgtctcctt accatcgcgt ctttccccct cacccccctt tgacttgggg
     6601 aagggcctcg tggcgagctg cctgacatgt actctcctac cactctgggt tatactaatt
     6661 atgatgagta acttaagtta catatcccct ggaggatcgc aactgcttat aatcgagaac
     6721 tcctgccgct gtcgaccgat agcctaagaa ggcagctcgg actggactta tccccatctt
     6781 cgcatggagc atggccagac tattgacttg gtttccactc ttcactggct tggtgacctt
     6841 ggcgtagaca ccttattatg tagacgcttt tactgactcg gttgtatagc ctggaagaag
     6901 tgctgagtac ggtcagtgct gaacaggact tgatggaggt ggctcaggct gcagaaatgc
     6961 cgaatggcaa aggattggtg gatgatggtc tggtctgcag gattgtaagt aagcacggaa
     7021 atgggctgac aggctttcta aagtctccca gtccgttgca acccgtgatg ggggtggctg
     7081 accgtgcatc ctgtcaatac gaagaaagag attgaggaag accgtgcaga gtaagacact
     7141 caacccaaac cgataactag actatcgcct accgcatgaa gttatctaag aaagaaggtg
     7201 accatggatc tccaatccag cccagccttt tccctgtgcg attccatcca cgatccctgg
     7261 ctggctcatc ggccaatccg atcgccgctc cactgatcca tccacggatc caattcccga
     7321 tccatctccc agggactgca acatccactc gcgcgatcgg ccttccttcg cagtcttcgc
     7381 cttttgcgct acactttttt tgcgatcgag gatatcgcat acagacgata cccgtaggga
     7441 tttgctgtcc gtcgcagata aaccatcccg ttatcattac atccggtttc attcgataga
     7501 caccccttat tcgtcaaaat gcatgagcat gaaatgtcct acatgggccc tcggggtatg
     7561 atcccttcct accttcatag ccacaatctc ccataaacta acggcaccga taccgaagcc
     7621 ttcagtcacg atcagagcca agatgcagag gctgaatatg accgactccg caacctagcc
     7681 cgacaagaag cttcaaagcg caactcatgt ttccaacggg tacgccatta acaaccactg
     7741 tcgcaaccac ccaaccgctc gccaaattag agaaagaaac aaacaactaa ccaatattta
     7801 atggtcagtc tcaagaagcc tactccagcg gcgatggcgc caaggccaaa gaactctcgg
     7861 aacaaggcaa agcccacggt cgcaagatgg aagaatacaa caagcaagcg tcggagttca
     7921 tcttccgcga gaacaacgcc aacgggcgtg ttgcggcaga caccatcgat ctgcacggac
     7981 aattcgtcga agaggctgag gagattctcg aggagaggat taaatatgcg aaagcgcacg
     8041 gtcaggatca tctccatgtg taagcttccc tttcacgtta ctctcacaca cactggcttc
     8101 ttctttaccc tcgacactga tcgctaattg ttacaatttt ccccaatcaa tagaattgtc
     8161 ggcaagggca accactccgc caatcatatc cagaaaatca agccccgagt agagcaagtc
     8221 tgccaggaac tcggtctcca gtacgcgact gaggagaacg cagggcgcat ttatgtgaat
     8281 ctgactggtg gaccggcgga tatggagact gcgccaacgc ccaatcatcc tcactatcag
     8341 caataccctc agcatcaaca gcatccgtcg ggtacctatg ctcacccgca tcagcagcag
     8401 cagcagcaat atcccggttc gcaacagcag cagcaacagc agcagcagca acagcaacag
     8461 cagcaacaac agggtgcggg caaccaggat gagatcgagc aggtggttaa tgcggttctg
     8521 cctaagattc tcaataagct ggagaaggct tgctgtgtgg tcatgtgaaa aggatttgag
     8581 ggacactggg ataaagattt tgtttgggca aaagagtatt ttttggccta tacatgatat
     8641 gatatgtggt tggtatagac aaagaagggt gcgtgagcag acacgactga tcattggact
     8701 ttcgcgcaat tgggcatttg gcggaagatt acatataccc cgggctgtgt gttggattca
     8761 gtatctagac ggtgattaac atgttctggt ttcttatctc tcccggatta gaagaggaga
     8821 agctaagaag ggaataagat cattgaagtt cgtattagag tcgccatgag tgcgcaatgt
     8881 ttcagattat aaggcatctg atcaataggc taaaatatat cacgtttcaa catcctgtat
     8941 aaaatacgag atcccatcca atcgaccaac caaccaacca gggatgggca gcgaattatc
     9001 cccgagaatg agtgcttgac catcgcctgt ttgaatctac tactggggac cacactcccc
     9061 cagtgtcgac tcggtgatct tgttgaggat cgcccgaacc atggcgccgt cttcgcgtcc
     9121 atctgcttgg tcaccatcga tcgcttgaat tagggtcagt gctttggctc gcaattctcg
     9181 gaccacgtcc cgcgtgtgcg caaaactgcc agtgctctcc atgtaactga ctgcatacag
     9241 tttgacttcg tcatctttcg tcttttgctt gagaatactc aggagctggt ggtttccggg
     9301 gttggatcgg atactatgaa tgatgggaaa ggagaacttt ccctccgtga gatcttcaca
     9361 aagacctttg ttcttggtgt acgtagtgtt ggacaggttg aggtagtcgt cgcagatttg
     9421 gaaaatcagc cccatgacgt tgacgaggct cacgcagtcc tttccggagc tactttcagc
     9481 ctgcatcaac ttcactgcaa gtcggaacaa acccccagtt ttgttaccga ccatttccaa
     9541 atactcgtcc tcgctggggc aagtcagagt atctcgccag aagagatcca ttccttgacc
     9601 gcggtgtagg ttcaataact cttggacgta gatgtcaatc gcagcggggt tgttcaactt
     9661 ttgcacctct tgcagagcaa ggaaatatac atagttcgca gagttgatgg tttgcgcggt
     9721 gccgtatatg ttatgagcta cgggaatacc gcgtcgcaaa atagagttat cctcgacatc
     9781 atcgatcctg gctcatacgc cataggtcag gtaggtgtcc agactaaacc gaggcacgat
     9841 gaaaacagct tacagtaacg atgcagtatg aagcatggcc accacctttg tgatgattga
     9901 gaggctctcc gggggtacct tcaaccatac gttgaaagcg ttgataagct gccgccgtat
     9961 gtctttgccg gggtgctgta gcatataatc gtatggtccc agaacgattc tctcattatc
    10021 tggcgaccat tgtccatcct tgtatttggt tccatcgacg ctggagcgat tacgattgtg
    10081 catgcgcgag tggttcgtgt ttgttgggag cccatcttca tccgggcctg tgtgatccat
    10141 ggctgggctc accaggagat caggctttcc taggctagct ccgcccttgc cgtcaatgga
    10201 attgcctgtg agggaatata atccaggttg agaagatctg ctagcagaga aatctggaaa
    10261 cggccctgca gacatggctt gattgttaac tgcttgcgtg ttctacaggt gatcactggg
    10321 gtctcgtcgc gaacggagag agaggggagg gggtcttcgg cgagcggaca atgctgtaac
    10381 aaccaggcaa ccgtgagaaa agggaggagt gagcaagccc atcttacagg tatcaggaat
    10441 agggcgcagt tgcactaagt aagttccacg ccctgcgaga atgaagagag gagtaacctt
    10501 aaaagggtgg attgcaggct gcgtttgctt ttgctttcgc tttcgctgcg gggaactcag
    10561 ccaagtgacg agggagcatc acatgccaat attgctttcc ccagctgggg tcacatgact
    10621 ctgggtcggc gaaactggga aactccgatc cggtgacagg ctggaatgcc tctcctcact
    10681 tcctcccctt cccctctctc tctcaagtta caccagattc ccctcctgtg tgattccgtg
    10741 tgacaagtgt gacgagtgtg acggaatttt ttttcaattc tactgtctgc aaggggtggt
    10801 gacgtttgag tggttgcacc agccacgagc agcaggttgt cgtgggcacg gtcggtgggc
    10861 ctgtaaacat tcagtccaaa ctatgctgga gactgtttcc gtgttggctg ttatactgac
    10921 cgacttcttc aaggaactct ttgcaaccca acgggtgacg gcatgataac cctcaggcct
    10981 ttatcatggc cagggattga cttagtggcg tagctgaaaa atggatcccc tttcttgaca
    11041 tcattagctg aaggctatca aggagatcct gttcttcatg gcgtctccgt agcacgccta
    11101 ttggaacacg atcgtgcgtc tccgggacaa ccatcgggtg tttttgtcgg atgtggggga
    11161 gctgcagtca ctaaggctgc ccagtgaccg agtctaaatc ggctcgatca gcttctcacg
    11221 atgacaacaa ctatttcttc gctagttgat cgagcccact gactatcgct caccaatcac
    11281 tgtagccttt aattaaggcc cccattttcc aagcgcctgg gctcagccgt gttcgattat
    11341 ttttctggct cctctctcct aagttaaggt actacatata gatagcgccg tatctcttgg
    11401 cccagggtcc tttgcgattg acagatcacg gcccgtcctt ttctttttca cccgtttccc
    11461 ttcacctgca acctagttcc tttttttccc ctgttaattc tggaaatagc cgtgctactc
    11521 atcacttctg ccttgtatta cccatggagg ctttgctggc acactcgttc gattaccttt
    11581 cctcttacga accaagcaaa gttcgcaaag ggctgcggca ggtcgaaggg cttctcgcac
    11641 agatttgttt atccaagacg aaacgcccgt cgtctgacaa acggcggtcc cttttgtctt
    11701 ttggggctcc gcaaccggtg cccaagtctt tggccgaact tcgagatgac ccggccttca
    11761 gggaattttt caagctccaa gaggggtttc aatggaatgg taagtttcgc tatccgcaga
    11821 ctcgcgatta tgtgagttcc caacactaat gcactgcaac cagtcgcaat gcgcttggtg
    11881 acatgtctcg aacacctgct tgggcggggg agcaatggca ccaatgacct tctcatcgtc
    11941 tccacactcg atctgataca gggcgtgctc ctccttcacc ctccatcgcg cacactattc
    12001 acgcgcgaaa tctatatgaa cctgctgctg gacctcctcg acccaatcaa ctgccccgcc
    12061 atccagtctg cgacccttct caccttggtc acggctcttt tggaccatcc cgccaacacc
    12121 cgcacgttcg aggagcttga cggactgctc acggtgacct cgcttttcaa acaacgtgca
    12181 acatcgcgtg aagtcaagct caaacttgtc gagtttctct acttctactt gatgccggaa
    12241 acacccatga tccccaccag cgcggccagt gcgcctaaca cggcagtcct tggacatcaa
    12301 cggagtccaa gtaaacttgg tgtttccccg gtctcccgga gtgtaaatgt tcccggcgct
    12361 cacggcggcg gaaaggcgca tcgggataca cgtacgaccg acgagaagca agcattgctg
    12421 ggccggtact tgaacaatgt ggaggatttg gtcgaggatt tgaaagaaac agcacccttt
    12481 ggagcaacag tttattagcg gtgttacgag cgtcattggg ttctgaatct ctttgtttat
    12541 gttgagcgtg catggataac ggtatcatgg ctggggttct ctttcttcaa tggtttcttt
    12601 tttcttgata tcctcaagtt tcttttttcc tttgttcctc tatttccttt gtctcttgtt
    12661 tactcttctt cagcctttcc cgtctggtac ggtctatgca tccggcacaa cagcctctaa
    12721 cctatttctt ccctcatttt ttgtcaacgc ttttcctata tgactcatgc atccgcttga
    12781 tgtctcatgt gtcacgttgc gatcatgtct ttataatttt atgcgaccct gaatgaattg
    12841 ttatgaacga gaatggcttt tttcccattg agtagtgcca tgcctgggcc gggccaatgc
    12901 atgtcttaga cccgagctcc ggcaacatct catccaaact ttctgagcca catcgctgtg
    12961 gaaaccacaa atctcttgta caatcccata tttacttact gatgtatatg tacaatatat
    13021 cgcctaccta catagctgtc tatttgaagg tctatgtagt tattccaacc caactctact
    13081 caacaaccaa cctccattct gcaaagtctg aaagaccccc tcgggatcat acttcctcgc
    13141 tacctccttc aaccgtctca cgttctcccc accatagctc gccaacggat cctgatccca
    13201 cgccgcatag ttcgaatact tgtaggggag atacacgccc gtttgctttg ccgcggattc
    13261 cgccgcatcc acgattttgc gcactgcctc gcgcacgcga tcctcatctt gaatattctt
    13321 ccagtctgct cgggcgagga accctgtacc acaagaatag atctattagc taccagaagg
    13381 aaacataaga cgtgttctcc cttcggggta tacgtacact gctgtccaac gggctccaaa
    13441 cctagaggag ttccgccatt cttgagcgtt tctctcatgg ctagcgagga catgggctga
    13501 atgacggttg ttagggcgat gccttctacg tccttgagag cttcggcttg ctcagcatga
    13561 gcttgttcga tggctttgta gacttctaga ctgggacggc tggacatggt gcggaattcg
    13621 tggctgcaag agttctttgg ttagtttgtt tctttgatat acttttcatg tttagaacat
    13681 gtaaagggag gatatatggc atacacagta ggctcggctt cattcacgga cgccacggcc
    13741 tgaactagat cgtaaacggt gcggattccc gggggtacga agctagtgag aaaaggaatg
    13801 tcatagaagg cctggaagac gggaggattc tcgacgggcg cgcagtagaa atagacgatg
    13861 agaatgatgt cgtttgtggc gttccagatg agagatgccc tgttgtctgt ttcaatggcc
    13921 tcgtggtatt gcattagagc ggcgcgcagt tggtcagctg ccgtgagggg gtagatgcga
    13981 acttcggtcc atatctggtt ggggatagtg ttcatttcga tcttagtgac aattcctggg
    14041 agatggtgga ttagacattt gatactgaat agtaatacga ccgtaaatgc tggtgttgct
    14101 ggtcatagat tagggtgatt gtgggtggta tagtaccgaa gttgggcccg ccacccttga
    14161 gggcccagaa tagatcggag ttttcgcggg cattggcatt tatgatctgg gaattggcga
    14221 gaacgacctg ttcagtgatt gttagctcct gtgttcttca tgggatgaag cgaggagatt
    14281 atactaactt cgtagttgca gacacccatg gcaccgacgc catactgact attctggaag
    14341 gagatgccgc cgccgagcaa caagccggaa acccccacgg taggcactct tcctcctgca
    14401 accgccactc cgtgctcttc aagagcgcga tacacttcca accatctcaa tccgacgcca
    14461 atttctgccg tggatttatc ttcagccaca cggacttggt caaatgctcc gagggaaatg
    14521 accacgccgt cctggttgct ggtgaagccc ggaatctgca aatggccccc accccggatg
    14581 gagaacttga cgtggaaaaa gcggcacagc gccagcgcag ctgcaacttg ttgggcagat
    14641 ccgggacgga caattacccg aggttgaagc cagcagttgg tagacctggc tcgattgtgg
    14701 tggttggtaa aggcattctt ttggtggtcg ttccaaaact atagacgtac cagggaacta
    14761 tacgctgcgg ctcatagcca ttggacccgt gcacgacggc agctgcgcca aagaacaggg
    14821 ggaagacggc agcaacgtaa gaggcccgtt cctggtcttg ttctgcagct gacaggctgt
    14881 caaatcgcga taagagggtc tctatatgcg tggccttctc ttgctctaga tggcaggcgt
    14941 tggcgacgat ctccgcgact acctcagcca ttgtgtgatc tatgcacgag ctatagatgc
    15001 aggtagttgt cacacaccaa attttgagga agtaaaagaa aagaaaggcg acgaagactg
    15061 agaagaaggc tcctgttact tgaattccgt gatccgaatg gtggatatcg gctgggaacc
    15121 gacaagacgc tatctgcgcc ggcgtcttga gcgatcctgc ccccaggatt caaacccctg
    15181 tcaatgtttg acaagcctcg aatttagagc ctgaaaatcc taagttcgtg tttcatttgt
    15241 acgttaaagg tattggcatc atcgacttgc attccttcgt ggtccacagc accccagcca
    15301 aatagtctag aaatgatggc tctccccgat tttgcattct cttctctgtc catcctgatg
    15361 accacctctg ctttggtgcg tgagagccgg tcaggatggg tgggtctatc gagcaacagg
    15421 acgatgtgcc aacatcgtcc atgaccatcg cggtgcggat tattgtgttg gtgctggcga
    15481 ttccgacaac cttggtgtgt gtgcttcgag tatgtttcct caacattcct gcaagcaatc
    15541 tggaggccaa aatgactgag ctgttgtagc tgtatctgcg caagttcgtt cttaataact
    15601 tcggacttga tgactggttg gtgctggttg ctcttgtgag ttacgcagcc ggtaatattt
    15661 ccccgcgcat gataactgac tgactagatc ggagtggatc tgttctctgc cctggcgtat
    15721 atcatcacat actatggatt gggccgacct atgaaatatg ttcctacaga tcatctggtt
    15781 gtgtttctca cggttcgtac atcgaggccg agagctttta cccaaactga tctttgcagc
    15841 tcgaatacgc ctcacaatgc gcctacctag tcatcgcagc gactgtaaaa gcgagcctgc
    15901 tcatcttcat catgcgtctg ttcccgactc gtttcgttca cattgccggg aaagctcttc
    15961 ttggtatcat cgcggccttc accctctcgg ggaccctcgc gctggtcttt cagtgtcgcc
    16021 cagtccaagc ggcctacgac aaggctatca ccaattctag ctgctatccc actgagacct
    16081 cgtacgcaat tcttatgatg caaggtgtca tcatgttcgt gctagatgta tcgatcctag
    16141 tacttccgat atggcctatc tggcagttgc agatgccgat aaggaggcga atacttgtgc
    16201 tggggctgct ctgcattggt aagctctcga gggaattcaa tagtccatta attaagtatt
    16261 gtccaggctt caccgcatgt gttgctgccc tcgtgcgctt ctcgacacta aaatttgcca
    16321 atgatacgac gaacttcacc tgtatagttc cttccaatgt cggcgggaga taaaaactga
    16381 cttcccttag attcagcttc cacgtccctc atttggatgg agattgaatt caatctcggc
    16441 cttatgtcag ggtctctccc ctctttgcga aaacttttca agcttggctc tcttttcccc
    16501 acgagccgct caacgaagac acagcaaagt tatacatcgg acttcgagct gcaccggcac
    16561 agttggacaa taactgggat tacaaagaag acagaaatcc agagggccta cgagagaagt
    16621 gagagccagg agttcattgc cccaatatat gggcagggag aattgaccac aactaccaaa
    16681 gcctatgcgg atggggagac aagctctgcc agtaatgttt gatgcccggg ccgtgatggc
    16741 taatgtgtgg gatctgtgac tcgacgatgt caatggagac atccaaagtc agagaaggtc
    16801 ggatcaggct cgagaattct atccgtgaaa attcgatgta ttgaatgcct attactgcct
    16861 ccgttaatgc cgagccggtc ggtgtatgag ggtcaagcca acgtaatgcc cgtatatccc
    16921 ggattgtctt cctatacgcg aaattgacct tggctagcgt gaaggttaat actttaccag
    16981 cccacccact ggcaggaata tagacagaga ctggccaaag tgttccctac attattgata
    17041 ttgctcgacc ggaccttgtc caaatggttt aatcggggta tatgactata actgatttct
    17101 ttgaggcgga agcctgtttc agttctagtt aggtagcatt gacacatata aggtgttatt
    17161 gtacagtgta attagaggat tctgtcacaa atccatccgt ctagaagaac ttgaggagtc
    17221 tgtcacgatg ttgtacaagg ttctcgtgtt ggcgcagcaa ctgtcccagc cgattccgtc
    17281 gccaccccag tttctcctcc aggattaggt gtgtgtatgc gaaaacacta gcatcgaaca
    17341 gacccggatt cggtcggtcg aagaagtgtt ggttgtcgcc cagtagcgta gacagtgcct
    17401 cgaatgcatc gttggcttcg gcttccaagg cgcccacatc gatataagat gacgttttta
    17461 ggatctctgt ccgggcagct tgctggagtt gcagggcgag agcggtccgc acggcggaat
    17521 ttgtactgga cgggttcacg tataatggtc gagcaacggc ctcgaactcc tcagggtcca
    17581 ggtataaggt atatagctgc cccagtgcca ttccagtcag tcacatttca tctatcgaca
    17641 tttcattccg ggggaggggg accgcaacgc acccaagcat ttcgtatccg atgatccagc
    17701 aacgacgcat atacctcgaa gcgcagatcc aactgctgct cctcctcgca gtgcacttgc
    17761 tcaatggccc atttttggag cttgctggaa ggaatagggg cgttgttgtt gatggggtgg
    17821 gcggggatca ggaaaggaag ggcgccagag ggagatgcat ggttgttgga aggaatcacg
    17881 tcgacgtcga tcccaacgaa tcttaagtat gcctgcagag acgcagagaa ataacagatt
    17941 agtgatgatg tactggagac gtggtgtaat gctgcatttc ggagtacgta cctgccactt
    18001 gagacactgt gggttgaacg acggtctgcc atgcctggca cttgcggcat cggtgaagac
    18061 atacagtcga ttgccacgtt tatctgacca tgcgctgtgc gggagatcat tggaggggta
    18121 ggtgacgagg gggaaacggt cgaagatgcg cttgattggt gtaggaacgg agaaaaagtc
    18181 tcgagcgcgc gacaccgtgc tcacattgtc cggtgtctgg ccagggtcat cacggtattc
    18241 gggggtcat
//
