LOCUS       MCQH01000110           18204 bp    DNA     linear   PLN 27-JUL-2021
DEFINITION  Aspergillus niger.
ACCESSION   MCQH01000110
VERSION     MCQH01000110
KEYWORDS    .
SOURCE      Aspergillus niger
  ORGANISM  Aspergillus niger
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Eurotiomycetes; Eurotiomycetidae; Eurotiales; Aspergillaceae;
            Aspergillus; Aspergillus subgen. Circumdati.
COMMENT     'Annotated using 1.8.7'.
            ##antiSMASH-Data-START##
            Version      :: 5.1.1
            Run date     :: 2021-07-27 13:34:31
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 121663
            Orig. end    :: 139867
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..18204
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="join{[132205:134240](-),
                     [131663:132121](-)}"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(join(10001..10458,10543..12577))
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     cand_cluster    1..18204
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..18204
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="terpene"
                     /region_number="1"
                     /rules="(Terpene_synth or Terpene_synth_C or phytoene_synt
                     or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps
                     or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /tool="antismash"
     mRNA            join(389..532,597..1868)
                     /locus_tag="ATCC10864_004832"
                     /product="hypothetical protein"
     gene            389..1868
                     /locus_tag="ATCC10864_004832"
     CDS             join(389..532,597..1868)
                     /codon_start=1
                     /locus_tag="ATCC10864_004832"
                     /note="CAZy:GH88"
                     /product="hypothetical protein"
                     /protein_id="ncbi_ATCC10864_004832-T1"
                     /transl_table=1
                     /translation="MSIEAGPPTTINGTEVLPTKQWARVLEALFSESLLAKVWFVASKA
                     MGSTTPPTFYPEYTGEDKTTYIYRTLDFWTSGFFPGSLYLLLERSTLFRDRHLILQRQT
                     SESILHPHPLQHEHLCRWWTANLHQNALRKDTHDLGFMITPWAMKAWTLHRDPAAYNTL
                     ILAAHSLASRFNESTQCIRSWDQCITKRYAYRNSSQDFLFIIDNMLNLDLLFWAARETG
                     CRRLYDIARAHAITTQKHHIRDDYTTFHVVDLDLETGEVKKKFTNQGYSDDSCWARGQA
                     WGIMGFAQTFEWTREMRFLRTARALADVFLARLPDDGVPYWDFDAPVTDTSPRDTSAAM
                     IAACGMLLLYKAYKKLHDVEAANHYLRAAMKLVDCTVVGYLNPPMRFEAGPASEISVYA
                     DQCSTHHTETRNGAEVLRVVGDVAETILTGATINNYEFAPRRWSDHGLVYADHYFLLFG
                     NMLLEMDLVDPHI"
     mRNA            complement(join(1995..2634,2862..2966,3024..3583,
                     3645..4643,4710..4867,5164..5219,5362..5413,5459..5531))
                     /locus_tag="ATCC10864_004833"
                     /product="hypothetical protein"
     gene            complement(1995..5531)
                     /locus_tag="ATCC10864_004833"
     CDS             complement(join(1995..2634,2862..2966,3024..3583,
                     3645..4643,4710..4867,5164..5219,5362..5413,5459..5531))
                     /codon_start=1
                     /db_xref="PFAM:PF00172"
                     /db_xref="PFAM:PF04082"
                     /locus_tag="ATCC10864_004833"
                     /product="hypothetical protein"
                     /protein_id="ncbi_ATCC10864_004833-T1"
                     /transl_table=1
                     /translation="MSLQSRLIVATVHSTTLVSREWHVVDAKFWFLLLVSDRWTDWFLM
                     THSLTRRESLVLLRILPGHYLFNYVDPLPIRLSIKHIKPLAKSFWENLRRRTLAGNYPA
                     RRQEADWRSIAGKTIPPWGRRSLCMPDSVCQTSPSWRQCSHGKSLNNLNSAYPMPPKSH
                     PATANANVGDLPETTTKGEEEIPACQFCRKKKAKCNRAQPCSQCMRSDVLCVYDDRRTK
                     PGLRAGAVDQLYRRVETLENMFLGQEMLWQQMWKALFPNTEPPRSLDKGTTAATTLTER
                     REQLKASLQEPPPLAAKRSLTVADADNSAPLDCVPLPAKRARVEDEVAPHAAVLEPEPF
                     LANSIPDIVLNELVDFYFVNIHPWIPILHVKRFRERMRSPEERGHINCILHAIISVCAR
                     FSQNGPNGDTLNLKEIAKKSRQEVILQSTETFSVENLQALVIVAFETINRGRGPSSWSI
                     IGSMAGTVEQLQLGVEEDDLYRVKRMGERLIRRMVFLTPSRSWSEAEERRRVFWAVFLM
                     DRFCSVSTGWKISLRNADVKRRLPCEGALWEKEQEVCTPYFGISDFKNTSMPNSHSTSM
                     DGSEEQAIGAFAYIIEATESLALVTNFYLHHVFLINDASKARLWLVKFKELDLRLIQWK
                     IHLPPKWREACVLNEHRVMDPNRLWHTSPTIRRVPPSPALNTLIANLMEISQRWTRHHD
                     ASESQQEESLAFKFATRLIEAQQNRTSASRPSLDIRTTAYSDESKEEMYKDPMRTNQDD
                     LPDYESLSRPLQLASFPSQESTSCTFDPFSLAFPPLPPAFQQDFSPTGLDPLSFYNMQL
                     PSESMSSPLGTRSHGSGSQHDSESSMTSLLPTDISHLFDMTSSPGQRISYYGNTRGVTN
                     NSIVEGADN"
     mRNA            complement(join(6022..6644,6709..7315))
                     /locus_tag="ATCC10864_004834"
                     /product="hypothetical protein"
     gene            complement(6022..7315)
                     /locus_tag="ATCC10864_004834"
     CDS             complement(join(6022..6644,6709..7315))
                     /codon_start=1
                     /db_xref="PFAM:PF16499"
                     /db_xref="PFAM:PF17801"
                     /locus_tag="ATCC10864_004834"
                     /note="SECRETED:SignalP(1-27)"
                     /product="hypothetical protein"
                     /protein_id="ncbi_ATCC10864_004834-T1"
                     /transl_table=1
                     /translation="MMKRKSQLSSFTLVTAAILPFAHLVMGGTSLAQKPQMGWNSWNAF
                     KATVNYTIVQEVISLFDTLGLKEAGYEYVLLDDGWASYNRTSDGYLQANATSFPQGIKA
                     LAQEVHGKGLKLGLYGDSGHYTCAWRPGSWGYEERDAQTFAGWGVDYLKYDNCGGFQSM
                     TEAPQIRFGAMKNALTLSGRDIFYSVCGWGYQFPWHWGGDIGHSYRMSGDITTSFTNET
                     ECQCKTAYCLNTGYAGCSVLTIINKMKEISQYQTPGHWLDMDMLEVGNANFTLNQQQTH
                     FAFWAALKSPLIIGADLSKLSNDSLAVLTNKAIISINQDALGEPVTYREAHSKEGLFQV
                     WAGKVEDGYVVLLLNEKSYPQTVSLSFASLGLGSPQKVIELWSGQTLQDLSKFNGTLGS
                     YQTLVFKVKA"
     mRNA            join(7688..7998,8052..8151,8201..8272,8966..9259)
                     /locus_tag="ATCC10864_004835"
                     /product="hypothetical protein"
     gene            7688..9259
                     /locus_tag="ATCC10864_004835"
     CDS             join(7688..7998,8052..8151,8201..8272,8966..9259)
                     /codon_start=1
                     /db_xref="PFAM:PF02469"
                     /locus_tag="ATCC10864_004835"
                     /note="SECRETED:SignalP(1-20)"
                     /product="hypothetical protein"
                     /protein_id="ncbi_ATCC10864_004835-T1"
                     /transl_table=1
                     /translation="MIFSFAPIIGLLSLISPVIATTDPLNYRNIPGYVTSSSLNVTTLV
                     DFIKSRSDLSILSEKIDELGGFAQAFDTDPNWKFTLFAPNNDAFELYTGAYFDSFEPTP
                     KGKWWLGNTIIHHYVPNSRLTSSSFNETLQRFQTATYLFVGSQMQDGAIVLNQVANVQN
                     QYLYCHPNLEQRHPKMRLLTYLLLTIYATSAVSTDLSVEEECGSLGVMKVDPADLPEGV
                     TLADVRKCADHPLGHLPHPGAATGGVLQRILPGWMF"
     mRNA            complement(join(10001..10458,10543..12577))
                     /locus_tag="ATCC10864_004836"
                     /product="hypothetical protein"
     gene            complement(10001..12577)
                     /locus_tag="ATCC10864_004836"
     CDS             complement(join(10001..10458,10543..12577))
                     /codon_start=1
                     /db_xref="PFAM:PF00432"
                     /db_xref="PFAM:PF13243"
                     /db_xref="PFAM:PF13249"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: terpene_cyclase"
                     /gene_kind="biosynthetic"
                     /locus_tag="ATCC10864_004836"
                     /product="hypothetical protein"
                     /protein_id="ncbi_ATCC10864_004836-T1"
                     /sec_met_domain="terpene_cyclase (E-value: 1.4e-24,
                     bitscore: 78.6, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MAHQETMASETSISLHTLACDATKLAGTYALRQVREDGHWYGEMK
                     SNATITAEYVFLAQALGFSIEEDRDDLIKYFLSEQNTDGSWSLAYDFPGDVSVTAEAYF
                     ALCLLGLDRSHPAMASAREFTLSKGGIAKVRVFTRMFFACFGLFPWSAVPELPAELILL
                     PAAAPMSIYRLASWARATVVPMLVIRHHRPIYALPNGRSSSNEYLDELWVDPTDKMVPY
                     SPSLWSLWNDDLTAFGFTLADNILKALGGLRWFPSRKIALRHCVAWILERQEPEGDIGG
                     IFPPLHAALFALALEGYGLETSPVRRGIDALQNTYAWRDSTGLRIQGCISPIWDTILMT
                     IGLIDSSLPAESPLVARSSRYLKAHQQLGNEGDWRVYNGNVPSGGFSFEYFNSWYPDID
                     DTAAAILAMVKQDPNLLDLGPILSAVQWILGLQNDDGGWAAFDRENNYLFLNKIPFSDM
                     DSFCDPSTADVTGRVIECFGLLAKRGSVLSRNGKNPIPRFFIDDMSSATERAIDFLSTE
                     QEADGSWYGRWGSNYIYGTSAVLCGLVYHLEGWDDTYPVMEKRHKVDTHAALDWLKRHQ
                     NPDGGWGERLESYYEPSLAGNGPSTASQTAWALMGLLAYLAPTDESITRGIQYLSRTQI
                     KEGELAGSWKEDHYTGTGFPNHFYLCYTLYSQYFPMMALGRYTRFDRPDARYVKFNIKL
                     ISLRSTVKTSQKLIPGFDLMDIGNDVVFGNRSCLGTVDRLGRKPIVIKDGAMLGDRSVG
                     LPRVNIGTRTMVGSGALLRRNGSYPDDRRSYCQRWQIQRTIDILIEESFGGRGIPVVNQ
                     RDSVPELVLSGDGAQDRV"
     mRNA            join(14387..14667,15189..16041)
                     /locus_tag="ATCC10864_004837"
                     /product="hypothetical protein"
     gene            14387..16041
                     /locus_tag="ATCC10864_004837"
     CDS             join(14387..14667,15189..16041)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 119; E-value:
                     2.9e-36)"
                     /gene_kind="transport"
                     /locus_tag="ATCC10864_004837"
                     /product="hypothetical protein"
                     /protein_id="ncbi_ATCC10864_004837-T1"
                     /transl_table=1
                     /translation="MPSDPSDLTALKPPTTATSQVDSESPLHETKVVSHRDTDRDSDAH
                     EKYIDGVLLHVIVLCLAVAMFLVSLDTTIISTAIPQITDEFNSTADVGCLEWGVSKSWH
                     DRDVIGCLVGFPILTGLFITNEFFWDDRAMIPRRLLLKKEVIVNLIVIFLLVGAFFMLL
                     YYMPIYFQTVKGNSAQDSGIRTLPLIMSAGVMAVFGAIGFGISGYPTPFLLFGAMLISV
                     GAGLLYTLDLVTLSSHWIPYQILAGLGIGAALQVPIIMNQATVDASDMSTMTSITLFFK
                     CLGASVFMQTGQTIFLEKVKRNLDMMTVADVNPNQILTGGLVRVQAIDSASSIALRTAY
                     LGGLKDVFLLVAALSGLVALLASLMGRYKMDTARLRL"
ORIGIN
        1 tttggagaca gcggatttgt gggtcaggaa gacaaaattg aggtgtagat aagatattaa
       61 tgtttggact tgtattccct agattcaggg tgatgaagag ccccgatggt ggggaagtct
      121 tagctgtaac gagtgtcttc taggctcgtc ggagggactc cgggagatag cccgaaatgc
      181 ctgtccagtg cattttagca gggagttctc gcgcggagga attcccggac ccccttccga
      241 gggctaatgc atacagcctc aaatggagca ggagatcttg tagatggacg gtcttgaaca
      301 cactttcaac cttgtatctt gcatctcatt cagtttatct tgaagtcttc ctctctatag
      361 cgtgcaaacc atatattgac taggaacgat gtctatcgaa gcgggacccc caacaaccat
      421 caacggcacc gaagtactcc ctaccaagca atgggcgcga gtactcgaag ccctcttctc
      481 agaatccctc ctagccaagg tctggttcgt cgcatccaag gcgatgggta gtgtgagtta
      541 tttcgccgaa ccgctaaatg tttcacacta tcctaaacaa aatacattct acatagacaa
      601 cccctccaac cttctacccc gaatataccg gcgaagacaa gaccacatat atctaccgaa
      661 cccttgactt ctggacctcc ggcttcttcc caggctcttt atacctcctt ttagaacgca
      721 gcactctctt ccgcgaccgg catcttattc tccaacgaca aaccagcgaa tccatcctcc
      781 acccccatcc cctccaacac gagcacctct gccgctggtg gacagcaaac cttcaccaaa
      841 acgcccttcg caaggatact cacgacctag ggttcatgat caccccttgg gcgatgaaag
      901 catggaccct gcatcgagac ccagcagcct acaacactct catactagca gcccactccc
      961 tcgccagtcg ctttaatgaa tcaacccagt gtattcgtag ctgggaccag tgcatcacca
     1021 agcgctatgc atacagaaat tcgtcgcagg acttcctatt tatcatcgac aacatgctga
     1081 acctggattt gcttttctgg gcagcgagag aaacaggctg tcggaggctt tatgatatag
     1141 ccagggctca tgcgatcact acacagaagc atcatatccg agatgactat acgacatttc
     1201 acgttgttga tctggacctg gagacggggg aggtgaagaa aaaattcaca aatcagggat
     1261 atagtgatga tagctgctgg gcacgaggcc aggcgtgggg aatcatgggg ttcgcgcaga
     1321 cattcgagtg gacaagagag atgagattcc ttcgcactgc tagagcactg gcggatgtat
     1381 ttcttgcgag attgccggat gatggcgtcc catattggga ttttgatgcg cctgttactg
     1441 acacctcccc acgcgatacc tctgctgcga tgatcgctgc ctgtgggatg ttgttgctct
     1501 ataaggctta caagaagctg catgatgttg aggcggctaa ccactacctt cgggctgcta
     1561 tgaagctggt tgattgtacg gttgtggggt atttgaatcc ccctatgcgg ttcgaggctg
     1621 gtcctgcgtc agaaatctcc gtgtacgcag accagtgctc gacgcatcac actgagactc
     1681 ggaacggggc ggaagtgctg agggtggttg gggatgttgc tgaaactata ctgacgggcg
     1741 caacaatcaa taactatgag tttgctccgc gaaggtggtc ggaccatggt ctcgtctatg
     1801 ctgatcatta tttcttgctg tttggaaata tgctccttga gatggacttg gtcgatcctc
     1861 atatataagg cagcgagtgt ggcagggagt agaagcatta aagaaccccc tctgaggggc
     1921 agggaagtag acataaaata tagaggcaca acgtaaatga gaggaaatat gatcacgcaa
     1981 gttctgttac tcgtctaatt gtcggctccc tcgactatcg aattgttggt cactccccgt
     2041 gtattgccgt aataactgat tctctgcccc ggactagacg tcatatcgaa gagatgagaa
     2101 atatccgtcg gcaagagact ggtcatggaa ctctccgaat cgtgctgaga acccgatccg
     2161 tggcttctcg taccaagagg cgaagacata gactccgacg gcaattgcat attatagaaa
     2221 gagagcgggt cgagaccagt gggcgaaaaa tcctgctgaa aggctggtgg cagcggtggg
     2281 aaggccagac tgaatgggtc gaacgtgcag gaagtggact cctgcgaagg gaatgaagcc
     2341 agctgcagtg gtctgctaag cgattcatag tctgggagat catcctggtt tgttctcatg
     2401 gggtctttgt acatctcctc ttttgattca tctgaatacg cagtcgtgcg aatatccaga
     2461 ctcggacgag atgcactggt tcgattctgc tgggcttcga tgagccgggt ggcaaacttg
     2521 aatgccaggc tctcctcttg ctgggattcg ctggcgtcat ggtgtcttgt ccaccgctgc
     2581 gagatctcca tcaggtttgc aatgagggtg ttgagtgcgg gtgaaggcgg taccctattg
     2641 tacctagcgt gtgcgaggag tgtgcggccg gcgatgaata gacaaaaaga aaattgggga
     2701 ttcgtgaaga tgggagaaaa ggacaggaat ttattagcaa tagttgctat ctctgaagcc
     2761 gcttcaaggc acgtatcagc agaggatgct gatgggagct taatgggaca gttctgccaa
     2821 tgcgatggtg gataggcgat gccctgatgc agcagaatta ccgccgtatt gtgggtgatg
     2881 tgtgccagag gcgattgggg tccatgactc tgtgttcatt taggacgcag gcttcgcgcc
     2941 atttgggagg caaatggatt ttccatctgc gcgcgtcagc atcactggtg tttagacatc
     3001 ccttgggaag agatgatacg tactgaatca gtcgcagatc tagttccttg aatttgacga
     3061 gccataatcg tgccttgctg gcatcgttaa tcagaaagac gtggtggaga tagaagttgg
     3121 tcactaaggc cagtgactca gtagcctcga tgatgtaggc aaatgcgccg atggcctgtt
     3181 cttcagagcc atccatcgaa gttgagtgac tattaggcat ggaagtgttc ttgaaatcag
     3241 agatgccgaa atacggggtg cagacctctt gttccttttc ccacagagca ccttcacacg
     3301 ggagacggcg cttcacatca gcattcctca gactgatctt ccagcctgtc gagacactgc
     3361 agaagcggtc catgagaaag actgcccaga atacacggcg acgctcttct gcttcactcc
     3421 atgaccgaga tggtgtcaga aaaaccatgc gcctgatcag tctttctccc atgcgcttga
     3481 cacgatacag gtcatcttct tccacgccaa gctgaagctg ctccacggtt cccgccatgc
     3541 tgccaatgat agaccatgag gagggcccac ggccgcgatt aatctgttcg aatgaaatca
     3601 gtctacttgt tcccggatat ccatggcgtg ggcctcatgc tcactgtctc aaatgcgacg
     3661 atcactagcg cctggagatt ctcaacggag aaggtttcag tgctttgcaa tattacctct
     3721 tgccgacttt tcttggcgat ctcttttaag ttcaacgtat cgccatttgg gccattttgt
     3781 gaaaagcggg cacagacaga gatgatggca tgtaagatgc aattgatatg ccctcgttcc
     3841 tccggcgatc gcatgcgctc acggaatctc ttaacgtgta gtatcggtat ccacggatgg
     3901 atgttgacaa agtagaaatc caccagttcg ttcaagacga tgtcaggtat agagttggcc
     3961 aagaaaggct cgggctctag gacagccgca tggggagcca cttcgtcctc cacacgggcg
     4021 cgtttggctg ggagaggaac acagtccagt ggtgcagaat tgtcggcgtc tgccactgta
     4081 agtgacctct tcgctgctaa gggtggaggc tcctgtaatg aagccttcaa ctgctcccga
     4141 cgctccgtca gggtcgtggc tgccgtggtt cccttgtcca gggatcgcgg gggctcagtg
     4201 ttcgggaata aagccttcca catctgctgc cagagcatct cctgacccaa aaacatattc
     4261 tccagcgtct cgacgcgccg atagagctgg tcgaccgccc cagctcggag accgggcttc
     4321 gtccgtcgat catcgtagac gcaaagaaca tccgatcgca tacattgcga acacggctgc
     4381 gctcgattgc acttggcttt tttcttgcga cagaactgac aggctggaat ctcctcctct
     4441 cctttggtgg ttgtctctgg caagtctcct acgttggcgt tggctgttgc gggatgggat
     4501 ttggggggca tcgggtaggc agagttgaga ttattgagag atttaccatg tgaacattgt
     4561 ctccaggaag gagatgtctg acatacagag tcaggcatgc acaaagaccg acgcccccat
     4621 gggggaattg tcttccccgc aatctgcact tgtcatgcca ctcctggcac atcctctgca
     4681 ccgttgagtt cgtagacatg gagacatacg ctgcgccaat cagcttcctg tcggcgggcg
     4741 gggtaattgc cggcgagtgt ccgacgccgg agattttccc agaatgactt agcaagtggt
     4801 ttgatatgct taattgaaag tcgaataggc aatggatcga cataattaaa tagataatgg
     4861 ccaggaactt ccgcttgtca gtccacgcag aggctcgtcg ctactattga gtcttcatta
     4921 agatttgggg cgcgctggcc ctaaccgtac agaaaatgcc cttcactatc gcgcgtatag
     4981 attctcgaat agcaccggat tcttattaga ctatcgtttc cgttctttta aagttctagg
     5041 gtttggttcc accgatatgt acaggaaata ggagaaaata tttcctgcgg agtgcaagac
     5101 agacccacct gcagttaata tccagggtcc atgtcttcag ggaaggatcg gcggcgaact
     5161 tacgtatgcg caggagcact aaagactctc tccgcgtgag agagtgcgtc atgagaaacc
     5221 tgcaattcat tttgatcatg agtactttat ccctatctac ggagtccagg cagggtagtt
     5281 aatgtgtggc ggacgaaaag ggaggcagtt gtcgaaccct agtgcacggg atccagtgag
     5341 ctacgcaacc cgtcgaccca ccaatcagtc cacctgtcag agacaagaag taagaaccaa
     5401 aatttagcat caacttaaca ttcaggggcc agccaaagaa gcttgggata ccagttacca
     5461 acatgccact ccctcgacac gagggttgtg gaatgaactg ttgccactat cagccgagac
     5521 tgcagggaca tgagatggaa catcctcacc tccgtcaccc ccgattgata tgttcgcgga
     5581 agcgttacgc gctaaacaat gaggacggag cttggcatat gccggtatgt atttcttcaa
     5641 ggcctatttt tccttccaac tacttccata ttgggcggtt ggcacaagca atgtgtacga
     5701 atttcctata gaaagatcac aatgggatgt agtggtatat ctctgctcaa agtctcatgc
     5761 ttttcaccta atttaacaat tgtgattact gggatttgcc gttttcagac ttgtcttatt
     5821 tgggaatacg gcgggcaatt agaagacaat cgagcgtaat ttcagccttg agacataatc
     5881 aagcctactt tatattcaat atgtctcctt gtctactttg tgggtttgca gaaatttaca
     5941 gactcttcca gcgaatataa taagaaaata tgttatgaag atgaaggttg acagtttaaa
     6001 gccacaccat gcctcagttt ttcatgcctt cactttgaaa acaagagttt gataagaccc
     6061 caaagtccca ttgaacttac taagatcctg caaagtctgc cccgaccaaa gttcaatgac
     6121 cttctgaggt gagccaagtc ccaaactggc aaagctcaga gacacagttt gcggatagct
     6181 tttctcattc agcagcagaa caacatatcc gtcctcaacc ttcccagccc atacctggaa
     6241 gagaccttct ttgctatgtg cttcgcgata cgtcacaggc tcccccagcg cgtcttgatt
     6301 gatcgaaatg atagccttgt tggtgagaac agctaaactg tcattggaaa gcttgctgag
     6361 atcagcacca atgatcaagg gagacttcag cgccgcccag aatgcaaagt gcgtctgctg
     6421 ctggttgagt gtgaaatttg catttccgac ttctagcatg tccatatcca accaatgacc
     6481 tggcgtctga tattggctga tttctttcat tttgttgatg atggtcagta ctgagcaacc
     6541 ggcatacccg gtattgagac agtaggcggt cttgcactgg cactcagttt cgttggtgaa
     6601 gcttgttgta atgtcaccag acattctgta tgagtgacca atatctgcag gcaggtggaa
     6661 tgagtatctt aaggtagaag attggttggt ttgcagggtg tatctcacct cctccccagt
     6721 gccagggaaa ctgataaccc catccacaca cggaatagaa gatatctcga cccgaaagcg
     6781 tgagagcatt cttcattgcc ccaaagcgta tctgaggggc ctctgtcatc gactgaaatc
     6841 cgccacaatt gtcgtacttg aggtagtcga cgccccagcc cgcgaacgtt tgagcgtctc
     6901 gctcttcgta tccccagctt cccggtctcc acgcacaggt gtaatgacca ctatctccat
     6961 aaaggcctag ttttaggccc ttaccgtgca cctcttgcgc cagtgcctta ataccctgag
     7021 gaaaggatgt tgcattggct tgaagatacc cgtcggacgt gcgattgtaa cttgcccatc
     7081 catcatcaag cagcacgtac tcgtagcccg cctctttcag cccaagcgta tcgaacagcg
     7141 aaataacttc ttgaactatc gtatagttga ccgtcgcttt gaatgcgttc catgagttcc
     7201 agcccatctg aggcttttgt gcgagacttg tgcctcccat cacaagatgg gcaaaaggta
     7261 aaattgccgc cgtcactaag gtgaatgatg acagctgaga tttgcgtttc atcatgttgc
     7321 cgggtttgcc caagggtacg tgatgtgcag taaccgggaa gccatttttg gggtagttat
     7381 aagagatcaa ctgcagcaga tcttttctat gcaacctccg gagcttgtcc ggaatcccca
     7441 ccggagtaaa ggggccaggt agagtaaaga tactagctaa taaggctgca gcctttcagc
     7501 cgagtggtat aatctcattg gccgggtcag gtggatgaag ttgcggagat gctccgggag
     7561 atccagcggc caaactagtg accctgaaca aattgcatca tgaagcctct gaggtatctc
     7621 tttattttcc caggactcgc gtgctgaagt tgttacctca acttatccag ataacgagac
     7681 tcacaatatg atattctcat tcgctccaat tataggactc ctttctttga ttagtccagt
     7741 catagccaca actgatcctc tgaactaccg aaacatcccc ggctatgtca cttccagctc
     7801 cttgaatgtg acgactcttg tggatttcat caaatctcgg tcggacttaa gcatcctgtc
     7861 tgagaaaatc gatgaacttg gcggatttgc acaagcgttt gacaccgatc caaattggaa
     7921 atttacattg tttgcaccga acaacgatgc ctttgaatta tataccgggg catactttga
     7981 tagttttgag ccgactccgt atgtcagatc aatctttctg atcttgcatc aacgttgctg
     8041 atcctgcata ggaaagggaa atggtggctg ggaaacacca tcatacacca ctatgtgcct
     8101 aactctaggc tcacatcgag tagtttcaat gagactttgc agcgttttca ggtgagaata
     8161 cccgtccgat tacaatgtaa tcaactgatg tctagcttag actgccacct acctctttgt
     8221 gggatcgcaa atgcaggatg gtgcgattgt tcttaatcaa gtggcaaatg tggtggaatc
     8281 agatatcccg gttactagtg tacgaactca ttccttcctt gcaataccgg cgaatactat
     8341 cctcttatta atactagaca tagggtgtgg tgcatataat cgatcgtatt ctagacccat
     8401 caacacagat cttcgaaccc gaccttccac ggctgtcaca aacattcatt gcagggagtt
     8461 gctcgaatcc tgagctctca tattgttgac ttcagtcagc cactgcgaat aggccaggct
     8521 tgtcctgagt tacttgtcat tataagaatg tcatgttgtg ttgtggaccc tgccaagaga
     8581 aactaagtag tcagacagat atagactaac taatcaagtc tcaccgagtg ttggtttcat
     8641 tcacgggaat cgtatccctg tagatcaaat gctcaagtta aaacctacca aatcaatcac
     8701 catgattccc atgagtcatt ggcatcatcc atccacttgg acccatcaat accaggcggc
     8761 tatcaataca ccatggaaca aaggaatagg tcgtacagac agcaggcaac tgtcaaggcc
     8821 agtcctgcca cgttgtctgt ttattttcca cgccagtatt taaagcagca gcaaatttcg
     8881 ccctagggcc gccacacagt tagactacta ctagtaaaac caactaaaat ctacatactc
     8941 tctcttctcc caccttcacc ctcagcaaaa tcaatacctt tattgtcacc caaacctcga
     9001 acaaagacac cccaaaatga gactccttac ctacctcctt ctcaccatct acgccaccag
     9061 cgccgtatcc accgacctca gtgtcgaaga agagtgcggc tccctcggag taatgaaagt
     9121 cgacccagcc gatcttcccg aaggagtcac tctcgcggat gtgcgcaagt gcgcagacca
     9181 tccgctggga catctgccgc accccggggc tgctacaggt ggtgtgttgc aacgtattct
     9241 gcctggttgg atgttttgaa aggggtgtta ttccctgcat catgccttgg cttaaatatg
     9301 gccaaggtgt agtagctgag aacaatatgt gcgttgggaa gggggaaatc tgagactttc
     9361 ctatgggcat ttttgtgtga ttggaaggag gatgaagctt ttgtttgggc ggctgtacat
     9421 ctgccaaaag ctggaagaac aagagctgct acttgggcga tactgaagtg gaaatcctac
     9481 tataatttca gcatttcctg ttagattggt acctgtatac ctgcccactc agccataatg
     9541 tacgccccac agagccattg tttcttgaag attgcgagtg atatttagag cccgcagtgt
     9601 accgccgatt ccaaacccaa ccaactctca gattttggta tggtatatgc tcttctcacc
     9661 gcgcaaatgg tataagccct acggtcgtag tcgattcccc ataaacgcct ccgccggcca
     9721 gccctgcaac gtcgtcccat cctcaacatg atcccccgac agcaccaacg tatgctccag
     9781 cagacacgca tccttcccca tcgatgcccc cgatagcaac cgcgatcccg tgcgcatcac
     9841 actccgatcg cccacccgca gcggatgcag ctcaaaattc cctctggtat tgagatggca
     9901 taccaggctg gcatcatcca ccgtcacccg atcccccagc gtcaccaagt ccggctcggt
     9961 gagaaatatg tgcggttccc cgttggcgct caacgcacaa tcagacccga tcttgggccc
    10021 catcgcccga tagaaccagc tcaggtacgc tgtcccgctg attaacgaca gggatgcccc
    10081 tcccgccaaa agactcctcg atgaggatat cgatggtgcg ctggatctgc cagcgctggc
    10141 aatagctcct gcggtcatcg ggataggagc cattccgccg cagcaatgca cccgagccca
    10201 ccatcgtgcg cgttccaatg tttaccctcg gaagccccac agatcggtcc cccagcatgg
    10261 ccccatcttt gatgacaatg ggcttcctgc ccagcctgtc caccgtgccc aggcacgacc
    10321 gattgccaaa caccacatcg ttcccaatat ccattaggtc aaaacctggg attagtttct
    10381 gtgaagtttt cacggtgcta cgaaggctaa taagtttgat attaaattta acataccggg
    10441 catcgggtcg gtcaaaccct acccatcaac agtcactaga gttgccttta tggtcttcca
    10501 ctgtgctttc cagattttct agtggtctgt aaccggacaa actggtatac cgacccaagg
    10561 ccatcattgg aaagtattga gaatacaggg tatagcaaag gtagaaatgg tttggaaagc
    10621 cagtgccagt gtagtgatcc tccttccaag accccgccag ttccccctcc tttatttgtg
    10681 tccgtgaaag gtactgaatg ccccgggtga ttgactcatc tgtaggggct aaatatgcaa
    10741 gcaggcccat caatgcccag gccgtctgcg atgctgtgga tggcccgttg cctgcgagac
    10801 taggttcata ataggattcg aggcgctcgc cccagccacc gtcgggattt tggtgtcttt
    10861 tgagccagtc cagggcggca tgagtgtcca ctttgtgcct cttttccatg acgggatacg
    10921 tatcatccca gccttccaag tggtagacca aaccgcaaag taccgcgcta gttccataga
    10981 tgtagttcga gccccagcgg ccgtaccatg acccatcggc ctcttgctcc gttgaaagaa
    11041 agtcgattgc acgctcagta gctgaggaca tgtcgtcgat gaagaaccga gggattgggt
    11101 ttttaccatt tctggacagc acagaacccc tcttagctaa caggccaaag cattcaatga
    11161 cacgcccagt cacatccgcg gtggatgggt cgcaaaaact gtccatgtcg ctgaaaggga
    11221 ttttgttgag gaacaggtag ttgttctccc ggtcgaatgc ggcccatcca ccgtcatcgt
    11281 tctgcaatcc caggatccat tgaactgcag atagtatggg gcctaagtct aataggtttg
    11341 gatcctgctt caccatcgcc aagattgccg cagcagtatc gtcaatatcc ggataccacg
    11401 aattaaagta ctcgaagctg aacccgccgg atgggacatt tccgttatac accctccaat
    11461 cgccctcgtt tccaagctgt tggtgggcct taaggtatcg tgacgatcgt gcaacgaggg
    11521 gactttcggc cggaaggctt gagtcaatca ggccgatggt catgaggatg gtatcccaaa
    11581 ttggcgagat acagccttgt attctcaaac cagtgctgtc tctccacgcg taggtgtttt
    11641 gaagggcgtc aatacctcga cgtacagggc tagtctcgag gccataacct tccagcgcga
    11701 gagcaaacaa tgcggcatgc agaggaggga agatacctcc gatatcgcct tcgggctcct
    11761 ggcgttcaag gatccacgcc acacaatgtc gaagtgcaat ttttcttgaa gggaaccacc
    11821 gcaggccacc taaggctttc agaatattgt cggctagagt gaagccaaat gctgtaagat
    11881 catcgttcca taatgaccac aaagaaggcg aataggggac cattttgtcg gttggatcga
    11941 cccaaagctc gtccaaatat tcatttgaag atgatcttcc atttggcaaa gcataaatgg
    12001 gacgatgatg tcggatgacc agcatgggaa ccactgtcgc cctggcccaa cttgctagcc
    12061 ggtagatgct catcggggct gcagcaggga gtaggatcaa ctcggctggc aattcgggca
    12121 ctgcagacca aggaaatagc ccgaagcaag cgaagaacat gcgagtaaac acgcgtacct
    12181 tggctatgcc acctttggag agggtgaact cgcgcgctga agccatcgct gggtggctgc
    12241 ggtcgaggcc caacaggcac aaggcgaagt aggcttctgc ggttacagaa acgtccccgg
    12301 gaaagtcata cgccaggctc catgaaccgt ctgtattttg ctcggaaagg aaatacttga
    12361 tgagatcgtc ccggtcttcc tcaatgctga accctaaggc ttgcgcaaga aagacatatt
    12421 ccgctgtaat agtagcattg gatttcattt caccgtacca atgaccatct tcccgcactt
    12481 ggcgcagtgc gtatgtgccg gcgagcttgg tggcatcgca agccagggta tgtagagata
    12541 tggaagtttc gctggccata gtttcttggt gtgccatggt atccaaagaa aggtaaattg
    12601 tgagtttggt cagggcttgc tgatttcctg gtaaaatgag cgggcgtcca gcatctattt
    12661 agccggactt gccactcaag ggggcattaa agttagctga atgagacccg gacccattga
    12721 tccaccatca aagcagtact attggcaaac ggtgcctaag tcccccagtc aacacaagtc
    12781 tactctacag tggagcatgt gagtgcaagg gaatggcatc tccatttgtg cctggctaac
    12841 ctttcacaat tgcccgggcc ggcccactgg tggagagtat agttgtctag aacttgcaga
    12901 attcatcttt ctcatcatct tcttccttat cggcttctga tggagtaggt gataactcga
    12961 ttataacatt aataaatata ataaaccctt gatagaacgc aatagtaaac atgtggctgc
    13021 aatcgagcat agataatcag aaaggtggct gtagacagat cttgagggat tgtcaaaact
    13081 tcagccaggt tgactagata tgatccatgt atcatattgt cataattcct gtaagagtaa
    13141 taatgaatga acaaaaaaac agggaagaaa agaaaagaaa ggaaacaagg gagtatttcc
    13201 catctttccc tgtcccttcc tttcatgaac aatggttgtt cttggtatct aggtcctgca
    13261 tagctaacac caaaatttat tttgcactgg agtctgtaag gggtatcgac tgtatctttt
    13321 cacttattac tctttagtga aatggctggc tgatacttca gtgggtattt accatgcatc
    13381 gaaaaagcag gaatctgtaa gtctcgttct ctttctttcc ttcttcggaa agaagaagaa
    13441 aagaaaaaac ctaataatta actgaaaaca aatatactac tatataatgc tatattatgg
    13501 cccgttatgt tgttatcgtt gcctccttgt tatgtgatcc gtcagataca atttatgagg
    13561 acattttcat ttgctaaaga tctgaccgat cggaagcgaa acgttagttc tgaggtgtct
    13621 caatgcatca tcttgtatga ttctgcatat cgatagcttc ttgcgtaatt tcctaagagc
    13681 tgaagaatct taatggaaaa tagatagaca tgtcttgaag cagatgaata ctatacttaa
    13741 tacaagttcc cacacttgga ttaaacccct actaatcaga accgtctgcg attacaaaag
    13801 actcgattga aatgttttcg cgtatatacc tgagctcatc gacatcatat ctttggcctt
    13861 tccgaggaga gagggcaact ctgcatgtca ggcagccaca tagatcgaga catgtgggtc
    13921 cggaatcctg aggagtcctt gttcgactta cattgcctaa gactgtacgg agtaatgtgt
    13981 ctactcccga cctgtaaaat aattgcaggg gtaaatcgca aacgagcatg tcttggacga
    14041 tcattactct tttttgaagt gattaaaatg ataatatggg ataagctttc ccagccagcc
    14101 ggtaatttgt gaggacagga agggccaccc tagtctgcgt tggtaatgaa gcaatccttt
    14161 ggggccatgc tatgcaaatt ttaaagttag cattttacca gtcaatttct tctgtgaaag
    14221 cccattctga aagtgtctct acccatgctt gacttctccg aggcagcggt gaaagactaa
    14281 aagcaaaccc attgtttaga cttttttttt cgccttgctc attccagttc gtgctgagtc
    14341 cttcctgcag ctgttgtgtt ttgcatcttc aggacaaggc cgcaagatgc catcagatcc
    14401 cagtgatttg acggcgttaa agccgccgac cacagcaacg tcacaagttg acagcgaatc
    14461 tccgctgcat gaaaccaaag tagtcagtca tcgagatacc gacagagatt ccgatgcaca
    14521 tgagaaatac atcgatgggg tgttattgca tgtgattgtg ctttgcctag ctgtggccat
    14581 gttcctggtt tcccttgaca cgactattat ctcaaccgct attcctcaga tcacagacga
    14641 attcaactcc actgctgatg ttggctggta tggagctgca tttcttctgg gaagcgctgt
    14701 aactcaagca ccatggggaa aactatacgg attttacgat attaaatgga cctacctcct
    14761 cagcctactc atgtttgagt tggggtcttt gctttgtgct atttcccaca actccccaac
    14821 attcataatt ggcagagcaa ttgcaggaat aggtggatca ggcattgggt cggggatata
    14881 tacggtcatt ggggtctgcg tcccacccaa aaaagcccta tactggttgg cgtaacgggt
    14941 ctggcattct tgctcgccag ctttgccggc cccgttatcg ggggagaatt tacaagcaac
    15001 ttaacttgga gatggtgctt ctggatcaat gtacctgttg gcggagctac tttcgctgtc
    15061 ctcctcccct tatttcggcc accctttcga cgcgcgaatg taggagtatc acggaaagag
    15121 atcatcctcc agctcgatat accgggggtc attacattaa caggtgcatt actctgtttt
    15181 ctactcagcc ttgagtgggg agtgagcaag tcctggcatg atagagatgt gattggatgt
    15241 ctggtcggtt ttccaatcct cacagggctg ttcatcacga atgaattctt ctgggatgac
    15301 cgggcgatga ttccacgtcg attgcttctc aagaaagaag ttattgtcaa tctcattgtc
    15361 atttttctcc tggtgggcgc gtttttcatg ctcctatatt acatgcccat ctacttccag
    15421 acagtcaaag gtaactcagc ccaggactca gggatacgca ccctgccatt gatcatgtca
    15481 gctggcgtta tggcagtatt tggagcgata gggtttggta tcagcggcta cccgacaccg
    15541 ttcttgctgt ttggtgcgat gctgatcagt gtaggagccg gactgctata cacgttggat
    15601 cttgtcacgc tgtcgagtca ctggattccg taccagattt tagcagggct tgggatagga
    15661 gccgcacttc aggtaccaat cattatgaac caggctactg tcgatgcatc ggacatgtca
    15721 accatgacat ctataacctt gttcttcaaa tgtctggggg cttcggtatt tatgcagaca
    15781 gggcagacca tattcctcga gaaggtgaag cggaatctgg acatgatgac tgttgccgat
    15841 gtgaacccca accaaatact caccggaggc cttgtgcgtg tacaagccat cgattcggcc
    15901 tcaagtatag cactccgcac tgcgtacctt ggaggtctga aagatgtatt cttgttggta
    15961 gcagcactct cgggccttgt cgctctgctt gcgtcactta tgggtcgata taagatggat
    16021 actgcacgac tgcggctatg aatagtcgag ttacgtttct cataacccgg ttttctcaaa
    16081 ctcgagttta gagaagcaac accgttggaa agagctagga gaagaagaac atacatgcaa
    16141 aatacaaaat acttgcattc aatctaatta catctgagtc catcttagct tcgcccgaag
    16201 gctactaatc accggcccta cgtagaaggg tagactcatc accggtgggc gcccccaaac
    16261 tctaccaacc gctcaatcag agattatttc ccaagccaac gaaatgttca cgcagctacc
    16321 actgtgcctc atttccatac cacatccgat ctccccgttc cctgcgtcct caatacgagt
    16381 gccttcccca agggcacctt aattctccca gaagtcgagt tcgattggtg gatgtaaatg
    16441 gatcggcagc aaagctggag gtggcgaacg aatcgctgcc agccgctgga ttacagaggc
    16501 gcccggttga tcaggcctgg cgtcctgtcg cttgcgatac cactttcgaa gcttgggtgc
    16561 ctcgtttttg agaacgatag caaagccaat aagacctatg actagcaaaa ccttatccaa
    16621 ctcgtcccaa accattgtta cgaacaatgt ctgagcagag cagtgggaac tgggagagta
    16681 aagaaaagcg agacaaccga catggtggga gaaaggcttt atacctttgg agcaacccca
    16741 ttcgtgaggg aggatatggg ccaattccct gagaagtagg ctgtatacgg aaagcctatg
    16801 aagtaggatc cttctgcggc agcgagaaag gcaggattcc cggttgtaaa cagagagagc
    16861 tcgtggcagc gagcaagtta taatgtgggg cagcaagtag gtagactgtg aaccagtgaa
    16921 ccaggcagag tgcatggccg tgaacaaaga tattttgtgg cagcgagcaa tatcgagcat
    16981 gttatggtgc catgtgagcc taaggtgctc tatagttagc aaacatgtat tggataagtg
    17041 aattgttcat tcgttctcgt tctctcctgg aagggtaata cattcacgta cctttcagaa
    17101 gtcacaacca agctctaatg cgagccacag cccagtcatc atatcaaaat atatttatga
    17161 ttatcacatg tctgcaaaaa tgatagtgca tccactattc tccttcctga aagacattat
    17221 ccggtaatca atgtcttaac tgagtttaaa gctgtactgc tgctgtaaat ttggatgtct
    17281 gatagagcca tgttctccca ataacagcaa acaagtgctc ataatgtctc aacgtcacaa
    17341 caagaagaca ataatcatcc agtttcggtt ttatttgtac tggaagttgt taggccgtag
    17401 cagagcacta tcaagaagct aatctcggtc agcattaatc gcagtccttt gctgtggtaa
    17461 agtcgactca ccagagcata tcttcagaca caagataatc cacaacagaa gagctggtgg
    17521 aagccactgt gctacctcat caactctccc atggccctcc ctttctagtc aacatgtcct
    17581 attcccttta gctctcgaaa tacccgcatc ctttgcggct ctccaaccgg gctttcattc
    17641 tgggaataat catatgtgat tcatgctgtt ggtcacttaa agcatcgtct tgttcaatat
    17701 ggatgattgt ccgtttttga gattctagac aattctgtaa ctcctctgta actccagtat
    17761 gtaacgtaat caacggtcgg acgggccaca cggtcaggcg ggccatctgg taatactata
    17821 caaaagatat ctttttaaac ataatatatc tctaccatcc aggtctagaa gaattagatt
    17881 tcttctatat agattttaaa taatataaat aatatctata taccttctaa aaatgaatat
    17941 acttttactt atggacttat catattacaa tatctgtatt tatatgtatt atataagaat
    18001 ctggtttcat tatcaaagta aaaattctaa aaatctgaaa aattcatgga atacttattc
    18061 ttatatatat aaactatcta caaagttaga gcttcataga agtagtactg gttgatatat
    18121 aatagaatca aaaagacatc ttttatatgg gatttcagga tggcccgcct gaccgtgtgg
    18181 cccgttcgac cgttgattac gtta
//
