LOCUS       KZ851906.1             21616 bp    DNA     linear   PLN 20-AUG-2019
DEFINITION  Aspergillus niger.
ACCESSION   KZ851906
VERSION     KZ851906.1
KEYWORDS    .
SOURCE      Aspergillus niger
  ORGANISM  Aspergillus niger
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Eurotiomycetes; Eurotiomycetidae; Eurotiales; Aspergillaceae;
            Aspergillus.
COMMENT     'Annotated using funannotate v1.6.0-df4262f'.
            ##antiSMASH-Data-START##
            Version      :: 5.0.0
            Run date     :: 2020-11-02 07:38:58
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 404360
            Orig. end    :: 425976
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..21616
                     /aStool="rule-based-clusters"
                     /contig_edge="False"
                     /core_location="join{[415800:>415976](-),
                     [415613:415740](-), [415524:415543](-), [415311:415469](-),
                     [415241:415254](-), [415027:415184](-), [414882:414972](-),
                     [414796:414830](-), [414520:414738](-),
                     [<414360:414466](-)}"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(join(<10001..10106,10161..10378,10437..10470,
                     10523..10612,10668..10824,10882..10894,10952..11109,
                     11165..11183,11254..11380,11441..>11616))
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     cand_cluster    1..21616
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..21616
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="2"
                     /rules="(Terpene_synth or Terpene_synth_C or phytoene_synt
                     or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps
                     or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /tool="antismash"
     mRNA            join(<1396..1437,1542..1808,1965..>2183)
                     /locus_tag="M747DRAFT_303283"
                     /product="hypothetical protein"
     gene            <1396..>2183
                     /locus_tag="M747DRAFT_303283"
     CDS             join(<1396..1437,1542..1808,1965..>2183)
                     /codon_start=1
                     /db_xref="InterPro:IPR008253"
                     /db_xref="PFAM:PF01284"
                     /locus_tag="M747DRAFT_303283"
                     /note="EggNog:ENOG41; GO_component: GO:0016020 - membrane
                     [Evidence IEA]"
                     /product="hypothetical protein"
                     /protein_id="ncbi_M747DRAFT_303283-T1"
                     /transl_table=1
                     /translation="MVAKAIQLGLRIWEFIWTLLIMALIGNMIAEAFAGNPATINYTMF
                     VAAFSMFTLFYLVPASINIDWAIHPIFLIAIDTLNAILFLTAGIALAAKLECHSCSNDS
                     YTLNNEITNGAHNRTKRCREAQASTAFLWFAWAGYTASMILSIIMSRQTSVNLRGRTGP
                     ARGVTRPSMAQV"
     mRNA            2798..4244
                     /locus_tag="M747DRAFT_293908"
                     /product="GroES-like protein"
     gene            2798..4244
                     /locus_tag="M747DRAFT_293908"
     CDS             2961..3998
                     /NRPS_PKS="Domain: PKS_ER (18-334). E-value: 3.4e-35.
                     Score: 113.3. Matches aSDomain:
                     nrpspksdomains_M747DRAFT_293908_PKS_ER.1"
                     /NRPS_PKS="type: other"
                     /codon_start=1
                     /db_xref="InterPro:IPR011032"
                     /db_xref="InterPro:IPR013149"
                     /db_xref="InterPro:IPR013154"
                     /db_xref="InterPro:IPR020843"
                     /db_xref="InterPro:IPR036291"
                     /db_xref="PFAM:PF00107"
                     /db_xref="PFAM:PF08240"
                     /db_xref="PFAM:PF13602"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028:crotonyl-CoA reductase / alcohol dehydrogenase
                     (Score: 196.1; E-value: 1.4e-59)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="M747DRAFT_293908"
                     /note="EggNog:ENOG41; GO_function: GO:0016491 -
                     oxidoreductase activity [Evidence IEA]; GO_process:
                     GO:0055114 - oxidation-reduction process [Evidence IEA]"
                     /product="GroES-like protein"
                     /protein_id="ncbi_M747DRAFT_293908-T1"
                     /transl_table=1
                     /translation="MVKAIAVTAPETISVVSDWPKPTLRDDCILVKVVSVGLNPTDWKN
                     ALRSTPVVTVGCDYAGIVEAVGSAVTKPFRVGDRVFGLIRGCNPNLPYNGAFSEYVLAL
                     GDLQFAIPENLSFQEAATLGVGLGTIAQSLYQSLQLASFDHPLAQPEPILVYGGATATG
                     TLAIQFAKLSGYEVITTCSPETEGLVKSRGADHVVDYKSPGAADKIREVTQDQLKLVLD
                     TISTEETAAFCGRAMSSQGGDYTAMIDSKVPRVDVRSRWTLGYTVFGEELTFRGVHIPA
                     KPEDRAFAAEWIEKAAKLLADGKVVPHPVQLGSGGLQGVIEGLNFLKEGRVKGCKLVYN
                     VNETA"
     aSDomain        3015..3962
                     /ASF="ER configuration inconclusive"
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_M747DRAFT_293908_PKS_ER.1"
                     /evalue="3.40E-35"
                     /label="M747DRAFT_293908_PKS_ER.1"
                     /locus_tag="M747DRAFT_293908"
                     /score="113.3"
                     /tool="antismash"
                     /translation="WPKPTLRDDCILVKVVSVGLNPTDWKNALRSTPVVTVGCDYAGIV
                     EAVGSAVTKPFRVGDRVFGLIRGCNPNLPYNGAFSEYVLALGDLQFAIPENLSFQEAAT
                     LGVGLGTIAQSLYQSLQLASFDHPLAQPEPILVYGGATATGTLAIQFAKLSGYEVITTC
                     SPETEGLVKSRGADHVVDYKSPGAADKIREVTQDQLKLVLDTISTEETAAFCGRAMSSQ
                     GGDYTAMIDSKVPRVDVRSRWTLGYTVFGEELTFRGVHIPAKPEDRAFAAEWIEKAAKL
                     LADGKVVPHPVQLGSGGLQGVIEGLNFLKEGRVKGC"
     mRNA            join(<4474..4686,4749..5274,5323..5543,5596..5988,
                     6070..6109,6163..7431,7482..8302,8363..>9085)
                     /locus_tag="M747DRAFT_232671"
                     /product="P-loop containing nucleoside triphosphate
                     hydrolase protein"
     gene            <4474..>9085
                     /locus_tag="M747DRAFT_232671"
     CDS             join(<4474..4686,4749..5274,5323..5543,5596..5988,
                     6070..6109,6163..7431,7482..8302,8363..>9085)
                     /codon_start=1
                     /db_xref="InterPro:IPR003439"
                     /db_xref="InterPro:IPR003593"
                     /db_xref="InterPro:IPR011527"
                     /db_xref="InterPro:IPR017871"
                     /db_xref="InterPro:IPR027417"
                     /db_xref="InterPro:IPR036640"
                     /db_xref="PFAM:PF00005"
                     /db_xref="PFAM:PF00664"
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 160.9; E-value:
                     6.8e-49)"
                     /gene_kind="transport"
                     /locus_tag="M747DRAFT_232671"
                     /note="EggNog:ENOG41; GO_component: GO:0016021 - integral
                     component of membrane [Evidence IEA]; GO_function:
                     GO:0005524 - ATP binding [Evidence IEA]; GO_function:
                     GO:0042626 - ATPase-coupled transmembrane transporter
                     activity [Evidence IEA]; GO_function: GO:0016887 - ATPase
                     activity [Evidence IEA]; GO_process: GO:0055085 -
                     transmembrane transport [Evidence IEA]"
                     /product="P-loop containing nucleoside triphosphate
                     hydrolase protein"
                     /protein_id="ncbi_M747DRAFT_232671-T1"
                     /transl_table=1
                     /translation="MDNIHVCGDDEFGPRVVHCRGNFDFTLLFEECFFSIAPSALLLLV
                     LPLRYKQLWKHRTVIVSQSWAYWAKLVSAQVFGASQLCLLVLWLLPHTPRTQASLAAAV
                     LTLITSVGLLFLSHLEHLYSVQPSSLLNLFLSWTIIFDAVRARSLWLASYTVIATLYTA
                     SIAVKSVWFYLETKSKLAYFMKKNVQYGDEEIRRFYNRAFFWWVNPLLLLGFKQSVSLE
                     ELPYLDRALSANELHRKFSAHWASMPKTYENALAYCAVRAFRAPVFYSFLSRLMRIGLD
                     YTQPFLITRLTIYVGQKIPSKDDGYGLIGAFALVFILKGVMNCLYEHYIFRLITQIRGA
                     LVSVIYDKTLELKYDEYSDSAALTLMSNDIDNIASGIQNVHEVWASPIEVGIALYLLQR
                     QVAWAATVPAALSVAVFYSTHLLSKSAPGRQKVWMQAVRDRVAFASSYLDASSKFRHLM
                     VKMNLLAGTTTNLSPVLTLSLFTGVALHTGKRPLTVAQTFTSLSIISLLSGPLSNLIYS
                     GPKASAALECFQRIQAYLLASPRLDDRVIPPSHQHVSPYTNWTDMDTEGVGPIELQQPK
                     PSDTGIGHRSVAAKSDLLQIHQADFGWDRSSPATLRSIDLRCPPSSLTMVTGAVGSGKS
                     TLLQGILGEVPCLKGFIYSNVCEISFCSSRAWIRNRSIRENICQPLPFDEQWYRTVLYS
                     TALDQDIESFPHKDHTIIGSNGMATSGGQRQRIAIARAIYARKQLALFDDVLSSLDAKT
                     SEQVFQRVFGAQGILRRHRVAAILATHDQKLLAFADNAVLLQNGVITKQGHPQLLQPRN
                     LSGESAATSRSIEERQVALPGSQAAAGIASSNADEMNRKIGDLGIYAYYLRAAGPWQVL
                     IYFVSLVIGVFCSQFPNLWVQWWGEENARTPFGRLALYISVYALLAALGAALWAWCMWL
                     VFCRIVPTSSNRLHDYLVMKIDKAPLYWLTCTDSGITLNHFSQDMTLIDRSLPADFLKT
                     SKNFTQCLMSAIFICVGAKYMAPLIPLSVIVVYSIQKFYLRTSRQLRHLDLESKSPLYT
                     QFTETINGLVTIRAFGWQNSFREEHQELLQKSQRPYYMLFVIQRWLILVLDLSVAGIAI
                     LLVILSVFVRGTGPIGVSLVSLITFSQQLSELINFWTSMETSIGAVTRIRNFQKGHIAF
                     QNVSICYDLNSPPVLQQITLAIPAGSKLGVCGRSGSGKSSLLLPILRMVEIQSGDIYID
                     AVSLQSCPRDTVRDQVTVIPQEPVLFRGTIRDNIAGFSPMDDEIVLNALQKVQLYEHVQ
                     SSGGLDAEIDHLPLSAGQRQLICLARAIVKKRKILLLDEATSHVDNETDSLMQDIIRTE
                     FAGCTIITVAHRVSTLLDYDQIAVIDGGKMVEYGTPSELFERSGSLLRQLHDQQRLRV"
     mRNA            complement(join(<10001..10106,10161..10378,10437..10470,
                     10523..10612,10668..10824,10882..10894,10952..11109,
                     11165..11183,11254..11380,11441..>11616))
                     /locus_tag="M747DRAFT_339193"
                     /product="pentalenene synthase"
     gene            complement(<10001..>11616)
                     /locus_tag="M747DRAFT_339193"
     CDS             complement(join(<10001..10106,10161..10378,10437..10470,
                     10523..10612,10668..10824,10882..10894,10952..11109,
                     11165..11183,11254..11380,11441..>11616))
                     /codon_start=1
                     /db_xref="InterPro:IPR005630"
                     /db_xref="InterPro:IPR008949"
                     /db_xref="InterPro:IPR034686"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: Terpene_synth_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052:Terpene synthase/cyclase metal-binding domain
                     protein (Score: 221.8; E-value: 2.5e-67)"
                     /gene_kind="biosynthetic"
                     /locus_tag="M747DRAFT_339193"
                     /note="EggNog:ENOG41; GO_function: GO:0010333 - terpene
                     synthase activity [Evidence IEA]; GO_function: GO:0000287 -
                     magnesium ion binding [Evidence IEA]; GO_function:
                     GO:0016829 - lyase activity [Evidence IEA]"
                     /product="pentalenene synthase"
                     /protein_id="ncbi_M747DRAFT_339193-T1"
                     /sec_met_domain="Terpene_synth_C (E-value: 1.4e-19,
                     bitscore: 64.9, seeds: 87, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MAVTRVQQSISSPTVKIPRQDTSLTIRLPEMFVLFLSGEPIVNRH
                     YKSVKELSEAWISRECYFDERGRRRLQKTDFAYFCSIAAPDAEPEELRTVIDWGNWVFP
                     FDDLFDNGSLKDDPERAQILVEDLRAGMADEAGQRPVLSDYPIVQVHNSVWHRITQAQP
                     IGIRRRFARAMNDYCTGCLAQVRSCSKGELPSLEEMLCLRRQSAGVSPLFALVEYAHKL
                     DIPDHVFECKSIQEIERIGTDLVLLQNDILSYCKEEKEGVSHNLVAICRHNGMPAQVAF
                     NHVGEMLIERYRDWYLALAALPTWGERVDADVQEYIRGVQNVVRANLHWSFRSGRYFGK
                     ANDQVRKTGMVTVRGNNADFKLSMA"
     mRNA            join(<12880..13281,13341..14069,14122..14371,14439..>14542)
                     /locus_tag="M747DRAFT_313425"
                     /product="hypothetical protein"
     gene            <12880..>14542
                     /locus_tag="M747DRAFT_313425"
     CDS             join(<12880..13281,13341..14069,14122..14371,14439..>14542)
                     /codon_start=1
                     /db_xref="InterPro:IPR018713"
                     /db_xref="PFAM:PF09995"
                     /locus_tag="M747DRAFT_313425"
                     /note="EggNog:ENOG41"
                     /product="hypothetical protein"
                     /protein_id="ncbi_M747DRAFT_313425-T1"
                     /transl_table=1
                     /translation="MASSSQPQAGDRISSWGYSFSWTRDHLSREELEPLRQQYDTSAAN
                     ALERLQAIRATLMEESKAKGTSPPPSDLYVLLRDHRGDDDILAKFWTEVNTVPEWVDWE
                     QLQRGQQFFYRYAIANIVGFALQGFVAENSAAPGVIEVLVRTGGFSTRMLLGRLLETFQ
                     WLIQVTHCITSIRPGGEGHIASVRVRLLHASVRQRIIQLCRARPDYFDLARFGVPVNTL
                     DSVHSISTFCCNPMWLQLPKFGIQPTPEEVKDYIALFRYLGFLLGTPTSYFETVERSKC
                     TMESLLAHELRTTDTSRTVAFNFVECVTNLPGPFKVSKGFIEVGSRWINGDELCDELEL
                     GKPGLLFYLAFCGYCALVVAMAWVQRLFLSLDELLIAGFRSLLYGGVVQRKSRTRFEFR
                     YVPRIGKQTGKEAYRVGDAATTKASWIYHPMWTIPFKCLGVGLFEMVLLVMLGVSGVVI
                     VGVMTGSCEMIRIMLTLILTIHDNNHMNDAYGVYPG"
     mRNA            join(18129..18202,18262..18295,18366..18483,18581..18855,
                     19144..19444)
                     /gene="VAS2"
                     /locus_tag="M747DRAFT_293911"
                     /product="AP-1 adaptor complex sigma subunit Aps1"
     gene            18129..19444
                     /gene="VAS2"
                     /locus_tag="M747DRAFT_293911"
     CDS             join(18192..18202,18262..18295,18366..18483,18581..18855,
                     19144..19176)
                     /codon_start=1
                     /db_xref="InterPro:IPR011012"
                     /db_xref="InterPro:IPR016635"
                     /db_xref="InterPro:IPR022775"
                     /db_xref="PFAM:PF01217"
                     /gene="VAS2"
                     /locus_tag="M747DRAFT_293911"
                     /note="GO_process: GO:0015031 - protein transport [Evidence
                     IEA]"
                     /product="AP-1 adaptor complex sigma subunit Aps1"
                     /protein_id="ncbi_M747DRAFT_293911-T1"
                     /transl_table=1
                     /translation="MAIHYLILLSRQGKVRLAKWFTTLSPKEKAKIIKDVTQLVLSRRT
                     RMCNFLEYKDTKVVYRRYASLFFIAGCASTDNELITLEVVHRYVEQMDKYYGNVCELDI
                     IFNFQKAYFILDELLLAGEMQESSKKNVLRCISQQDSLEDMEVEEDVVTKIM"
     mRNA            join(<19977..19982,20061..>21041)
                     /locus_tag="M747DRAFT_303289"
                     /product="repressor of RNA polymerase III transcription
                     MAF1"
     gene            <19977..>21041
                     /locus_tag="M747DRAFT_303289"
     CDS             join(<19977..19982,20061..>21041)
                     /codon_start=1
                     /db_xref="InterPro:IPR015257"
                     /db_xref="InterPro:IPR038564"
                     /db_xref="PFAM:PF09174"
                     /locus_tag="M747DRAFT_303289"
                     /note="BUSCO:EOG09263FKC; GO_process: GO:0016480 - negative
                     regulation of transcription by RNA polymerase III [Evidence
                     IEA]"
                     /product="repressor of RNA polymerase III transcription
                     MAF1"
                     /protein_id="ncbi_M747DRAFT_303289-T1"
                     /transl_table=1
                     /translation="MKFLPLPEFEDVTSSLNFDTADCHIVGGCDLYTTKAARADRKLYK
                     NIEQSLESQYESVLRLSASLSPPNASDAAASLNLSRSSPFGPLSDHSSRRTFAYLIATL
                     NASHPDYDFSHVLRPSDFHRERNLKRVMNTIDSTLFNLRPREAIDLTPPSPVTISGSYN
                     AGASSTWGPRMWRVIDEHMSLKECSLYSFSPDEDPSDADDGAIWSLHYFFFNRLRKRVC
                     YLYLRAIPILSHTPSEGLATPTTKRTYDDGYLTPELASSKRARYWLGEGVELESESDEE
                     ASGSKPTRPVVDEYDHYLLSDEEFRSRSGSKGTVRAMSEEIADSMEV"
ORIGIN
        1 cgattattgc ttaagttgat cgtccttatg gcttctcact ggggtatatt gcgagctagc
       61 attaccccat cgatggcttt gatcgaccat ctagcgaaca atctgcgtca accgctgccg
      121 atatgctggg aatattaagt gccggcgcat ctcctgcata cacattggcg ccaattgagt
      181 tttcaagaca caagaagcct tgtacaggtg gccaggtaat tcggcacgca ttcccaatga
      241 tcgagtttgg aacacccaca gatggatatt agattgggct gggccttcgg gatgactggt
      301 tatgggggtc gtaccaccga cgcaaagtcg acggggctat ccgtcatagg aaggtagata
      361 tggaaacgtt tgcttttctt actctcacct tccccgtgat tgtgactgct gaaaactttt
      421 ggttcctatt tatctattta ttagtttatt tattcaaaca gccttgccta accgaggcgt
      481 gggttgggct tgcgagtgtg tgggcgggat cctctcatgg ccgctggaag agagtgaaca
      541 attacacttg cggcacaaag cagatcatcc ggtcaaggat ctgtcggctc ctgtttgctg
      601 catgtgtggt tcatggaaat ccagcaagct ctagtatggt cgggcatcat gcttggccag
      661 tcgaaaagtg agaagctctt tcagctacaa cgtttaaagt ttgcagaccc actggttgga
      721 gagcttaatg gaggctcgca tccccatcac aagcttgact agtgcagctt gactccgccc
      781 ataggtgacg gcatcaatgt ttcatgctcg gatgacctcg gaagcgatga ttgtagagcg
      841 gcgttctcta tgtgtctttc aatcgaagcg gtcgatcgcc tcgagggagg gaaaaaaggg
      901 ttgtaggatt ttcttcagta tgaatggggc aatgcttgga gcagactgca aaagcgccca
      961 acggcgccag gctgggcatc tttgggttca tcatggaact acgagtcagt gctgaatgac
     1021 aaaccaccta gaccgctctc tggctctatc ccacctgctt gatgttctgt ggtggaaaac
     1081 cccaagggtg cagcagtggt ggtgatttca tgagtcgggc cggcgcatga cgtagcagat
     1141 ccctgaaccg gcgcatatcg tcatcgttcg tgttgcccga tcatcccgca ctgagatgat
     1201 gtttcttata attatcaaac tccgtctaaa ctaataacta ctggccctcg tcccgattca
     1261 ttaatttccc ggtgccggat ctactgaaac agatcgacaa tctacaagaa gcacagccca
     1321 ccagacacgc accccatcgg caacaactct cattcactac caccactcat cactcattca
     1381 tatcacacca ccaagatggt tgccaaagct atccagctcg gcctacggat ctgggaggta
     1441 tgtcaatctg tctcgagccg agagccttgc tctggctgga cctgcaaagc aagcaagtga
     1501 agcagctggg aattctggac taacgctgaa gatggcatca gttcatctgg actctgctca
     1561 tcatggcttt gatcggtaac atgatcgccg aagcgttcgc cgggaacccg gcgaccatca
     1621 actacaccat gtttgttgca gccttctcga tgttcacact cttctatcta gtcccagcgt
     1681 caatcaatat tgactgggct attcacccaa tcttcttgat cgccatcgac acgctcaatg
     1741 cgatcttgtt ccttacggct ggtatcgctc tggctgcgaa attggaatgc cacagctgca
     1801 gcaacgatgt acgtatagtg catgattttc tgccttatca gtcggggaag ctatccacta
     1861 aaaaaagtgg agagtggagt tttcgtcccg cgaactccaa aaaagatgat gcaccacagt
     1921 aaaataatat taaggcaacg ctgacttgtg gatacttacc ctagtcctac acgctgaaca
     1981 acgaaatcac caatggagcc cataaccgca cgaagcgttg ccgcgaggct caggcctcga
     2041 cggcattcct gtggtttgcc tgggctggct acactgcctc gatgattctg tcgatcatca
     2101 tgtcacgcca gacaagtgtc aaccttcgtg gacgcaccgg tcctgcccgc ggcgttactc
     2161 gccccagcat ggcccaagtt taaagagtgg ttcatatcca cttctccgcc tcggctgaga
     2221 ttacgttgtt cgatgtgaat gtcactctca ggaatggaat ggaatgaatg acgaagcgca
     2281 actgggccaa ctatgaaatc agatgcaatt ggacacaagg cgctgattct ggctgatgaa
     2341 accgacttaa caatcttcat caaactcatt actaattcag agaaaaaaaa gaagtcctgg
     2401 ctgtacttgg ccgggaatca tggccgggga taattataat cgggaggaaa ggagttttgt
     2461 gtgtaattct aattatgttt tttttctttt ttttttttag tcatatgtac ttgatagttc
     2521 gtaatactga tcgatccaat gtgataaggc tcttggatac tgtcaaaatg tcagatgata
     2581 tttatttcca gtcagatgcc tacccacaac ccacaactct tgatttacgg tggtatgtgg
     2641 gatgctgctc cgaaactctt agagaaacgc cgagacgcga tgacctggac gacgatgtct
     2701 acatgccgac cggggaagaa gcaagtagac cgattgttta gaaagtcagc tcactccgga
     2761 ggctccggag gctgcatttc agctcctcac tagtcgccgg acgatcaatt cagagaagtc
     2821 aagcattctc ctctttccct tccaacagct acatacataa gactctctcg tctgctcatg
     2881 ctctatagta ccttcaaaat cctcaactat tctatgattt tctccgcctc ggtgcattag
     2941 tcacccggaa catcatcacc atggtcaaag ctatagccgt cactgctccc gagactatct
     3001 ccgtggtgag cgactggccc aaacctaccc ttcgtgatga ctgcatcctc gtcaaagtgg
     3061 tgagcgtcgg gcttaatccc acagactgga agaatgccct tcgaagcact cccgtcgtta
     3121 ctgttggctg tgactacgcc ggcattgtag aagctgtcgg ctctgcagtc acgaaacctt
     3181 tccgggtcgg tgatcgtgtc tttggcctca tccgcggctg caaccccaac ctcccctaca
     3241 atggagcatt ctcagagtac gtcctcgctc taggtgacct gcagttcgcc ataccggaga
     3301 atctcagctt ccaggaagcc gcaaccctag gagtcggcct gggcaccatt gctcaatctc
     3361 tgtaccaaag cctgcagctc gcatcattcg atcatcccct tgcccagccg gaacccatcc
     3421 tcgtctatgg cggtgctacg gccacaggaa ctctggcaat tcaatttgcc aagctgtccg
     3481 ggtacgaggt gatcacgacg tgttcgcccg agaccgaggg gctagtgaag agccgtggtg
     3541 ccgaccatgt agttgactac aagagtcctg gggcggctga caagatccgc gaggttacgc
     3601 aggatcagct gaagttggtg ctggatacca tctcgacgga ggagacggcg gcattttgcg
     3661 gaagggctat gagctcccag ggcggtgatt atactgcgat gatagacagc aaggtgcctc
     3721 gtgtggatgt gcgcagccgc tggacgctgg gttatacggt attcggagag gagttgacgt
     3781 ttcggggtgt gcatatccct gcaaaaccag aagatcgggc ttttgcggca gagtggatcg
     3841 aaaaggcggc caagttgttg gcggatggca aggttgtccc tcatcctgtg cagcttgggt
     3901 ctggtggctt gcagggtgtc attgagggac tgaatttctt gaaagaaggt agagtcaagg
     3961 ggtgcaagtt ggtgtataat gtgaatgaga ctgcctaact ctatggtaat atgctatcat
     4021 gactgcacgg agccccgacg gccgcgagac ttataaggcg gccccaagaa aggacggtaa
     4081 agcttaatgg tgcgtagcag cctcgcaggg agagtaccag gcagacatga atggggaatg
     4141 gaagaggcta aaatcagtct agaacccaga ttctctccgc gctgtgggtt attggatagg
     4201 actaagtaga cttgcgacag gggtttttac acccagtcac cttatcgctg ccatctaatt
     4261 gctggattta caacaccgtc caagattaaa gaggtggatg ggccagcgag attagctcct
     4321 taaaaggtac tgcttcgatt tcacctgaca ctcagcctca cttcacctca gcactccctc
     4381 gttaacctca cctttcaacc gttacaatcc gggtcccatt gctatttagc attccctcgt
     4441 cattaacctg cgtatcgagg atattccacg aggatggaca acattcatgt ttgcggagac
     4501 gatgaattcg gtccacgagt ggtccactgt cgagggaact tcgacttcac cctgcttttt
     4561 gaagagtgct tcttttcgat cgctccctcg gcattacttc tgcttgtact tcccttgcgc
     4621 tacaagcagc tatggaaaca tcggacagtc atcgtctctc aaagctgggc atactgggct
     4681 aagctggtac gtgcgtcttg tcaaggaatg aactgtcgct agctaactca cgcaccgcta
     4741 tctactaggt ttcagcacaa gttttcggtg catcccagct ttgccttcta gtcttatggc
     4801 tcctccctca cacgccacgg acacaggcat ccctggctgc tgcggttctg actttaatta
     4861 catctgttgg cctgctgttc ctgtcccatt tggaacacct atattctgtg cagccctctt
     4921 cccttctgaa cctgttccta tcatggacaa ttatcttcga tgccgtacgt gcaagaagct
     4981 tatggctggc ctcgtatacc gttattgcta ctctctatac agcaagcatt gcggtcaaat
     5041 cggtttggtt ctatttagag acgaagtcca aactggcata tttcatgaag aaaaacgtgc
     5101 aatatggcga cgaggaaatt agaagattct ataatcgcgc cttcttctgg tgggttaatc
     5161 ctttgctctt gctcggtttc aagcagtcag tgtctctcga ggaattgccg taccttgatc
     5221 gggctctgtc agcaaacgaa ttacatcgaa agttttccgc tcactgggct tcaagtaagt
     5281 agcagccaga tggcattttc agtgtctgct gactagtttc agtgccaaaa acatatgaga
     5341 acgcgttggc ctattgcgct gtccgtgcat tcagagcccc agtcttttac tccttcttgt
     5401 cgaggttgat gaggattggt ttggattata cgcaaccttt cttgataacc agattaacga
     5461 tttacgttgg ccagaaaatt cctagtaaag atgatggcta tggcctgatt ggtgcatttg
     5521 cactggtctt cattctgaaa ggcgtatgct atctagcccg ctcctttgat atttatcctg
     5581 atcaacttca tataggtcat gaattgcctt tatgagcact atatatttcg tcttataacg
     5641 cagatacgcg gcgctctggt atctgtcatc tatgataaga cgcttgagct aaagtacgat
     5701 gagtacagtg actcggcagc gctgactttg atgagcaatg atatcgacaa cattgcatcg
     5761 gggatccaga atgtgcatga agtttgggcg agtcccatag aggtgggcat tgcactgtac
     5821 ttgttacagc gtcaggtagc ttgggctgct acagttccgg cagccctttc tgttgcggtc
     5881 ttctattcca cccatctgtt gtcgaagtct gcaccgggga ggcaaaaggt ttggatgcag
     5941 gctgttcgtg acagagttgc gtttgcttcg agttacctcg atgcgagtgt aagtatcaag
     6001 atgcttggcc tccaaaagca tttttctaga atgctacatc aactgcgcat tgacgagctg
     6061 aatcgacagt caaaatttcg ccatctgatg gtgaagatga atttgctcgg taagttcagt
     6121 ttgagcgaga ataaattgtg tcgagactca cggtgttttc agcgggcaca acaaccaatc
     6181 tcagcccggt cctcacactc agtctcttca ccggtgttgc actccatacc ggaaaaagac
     6241 cattgacagt ggctcaaaca ttcacatcgc tttcgataat ctctctattg agtggccctc
     6301 tgtcaaacct gatctattcg ggcccgaaag ctagtgcggc gctggaatgc tttcaaagga
     6361 tccaagctta cttactagca agtcccagac tcgatgatcg agttataccc ccgagtcatc
     6421 agcatgtctc cccgtataca aattggactg atatggacac cgagggggtg ggccccattg
     6481 agcttcagca gccaaagcca tcggatacag gcattgggca tcgttctgtc gcagcaaagt
     6541 cggacttgct gcaaatccac caggctgatt ttggttggga tcgcagttcg ccagctacat
     6601 tgcggagcat cgatcttaga tgccctcctt cttcgcttac catggttacc ggggccgttg
     6661 gatcgggcaa gagcactctg cttcaaggaa ttctgggtga ggttccctgc ttgaagggct
     6721 tcatttacag caacgtttgc gaaatatctt tctgtagtag cagggcttgg attcgcaaca
     6781 gatccatccg tgagaacatc tgccaaccct tgccttttga tgagcaatgg taccgaactg
     6841 tgctttattc gactgcgctc gaccaagaca ttgaaagctt tccccacaaa gatcacacaa
     6901 tcattggtag taatggtatg gcaactagtg gcggacaaag acaacgcatt gctattgccc
     6961 gtgcaatcta tgcacgcaag caattagctc ttttcgatga cgttctaagt tctctggatg
     7021 cgaaaacttc agagcaagtt ttccaacgcg ttttcggggc acagggcatc ttgcgccgcc
     7081 atagagttgc tgctatatta gcaacgcatg atcagaaact tcttgccttt gccgataatg
     7141 ctgtcttgct ccaaaacgga gtgatcacga aacaaggcca tcctcaattg cttcagccac
     7201 ggaatttatc gggtgaatca gcggccactt cacgctcaat cgaggagcgc caagtagcat
     7261 tgccgggtag ccaggcggct gcaggcattg cgtcttcgaa tgctgacgag atgaacagga
     7321 agataggcga cctgggcata tatgcatact acctccgagc agccggccct tggcaggtat
     7381 tgatctactt cgtatcctta gtgataggtg tgttctgctc tcaatttccc agtaagtcta
     7441 cctcccttca tggtcgactt tcattgatga aaggagcgaa gatctttggg tccaatggtg
     7501 gggagaagaa aatgcccgga cgccgttcgg aaggctagcc ctctatatca gcgtctatgc
     7561 tcttctggct gctctaggag ctgccctatg ggcatggtgc atgtggctcg tcttctgccg
     7621 cattgtcccc acgtcttcca acaggctcca tgattatctg gtgatgaaga tcgataaggc
     7681 tcctttgtac tggctcacct gcaccgacag cggcatcact ctaaatcact tcagtcagga
     7741 catgactcta attgaccgat cacttccggc tgactttctt aaaacatcga aaaattttac
     7801 acaatgcttg atgagcgcca tatttatctg tgttggtgcc aaatacatgg ctcccctgat
     7861 ccccttatca gtaattgttg tttactcaat tcagaagttc tacctccgaa catcacgaca
     7921 acttcgccat ctggacctcg agagcaagtc accactatac acccaattta ccgagaccat
     7981 aaatgggctt gtcactatcc gcgcgtttgg ctggcaaaac agcttccgtg aagagcacca
     8041 ggaactgctc caaaaatcgc agcggcccta ctatatgctg tttgtcatac agcggtggct
     8101 tattcttgtt ctagatctgt ctgttgctgg cattgcaatc ttgctagtga tactctcagt
     8161 ttttgtgcgc ggaactgggc caataggtgt ttcgcttgtc tctctaatca cgttcagtca
     8221 gcagctgtcg gaattgatca atttctggac atccatggag accagtattg gtgcagttac
     8281 acgcatccgc aattttcaaa aggttccctg agaggatctt cctggagagg aagtagttcc
     8341 tcgtacagat tggccatcag agggccatat agctttccaa aatgtcagca tatgctatga
     8401 tctgaactct ccccctgttc ttcaacaaat aaccctggcc atccctgctg gttccaagct
     8461 aggggtatgc gggcgctctg gaagtgggaa aagctctcta cttcttccca ttcttcgcat
     8521 ggttgaaata caaagtggtg acatttatat tgatgccgtg agtttacaat catgccctcg
     8581 tgacaccgtc cgcgatcaag ttacagtgat acctcaagag cctgtcttat tccggggcac
     8641 tatccgtgat aatatcgctg ggttcagccc catggacgat gagattgtcc tcaatgcact
     8701 acaaaaagta caattgtacg aacatgtcca gagctctggt ggtctcgatg ctgaaatcga
     8761 tcacctcccc ctatcagcag gccagcgaca gctcatttgc ctggctcgag ctattgtcaa
     8821 gaaaagaaaa atcttgctcc tggatgaggc cactagccat gtggataacg agacagattc
     8881 cctgatgcaa gatataattc gcactgagtt tgcaggctgc actattatta cagttgcgca
     8941 tagggtttct acccttctgg attacgatca gattgctgtc attgatggag gaaagatggt
     9001 tgaatatggc acacctagtg agcttttcga aagatcgggg tcgcttctcc ggcagttgca
     9061 tgatcagcag aggctcaggg tgtgatgatg ctacgatatt tggctttaag gtagtgcttg
     9121 tatgagatat ggcggaagga gctcgagggg acagactggg aaattcagag ctcatcctct
     9181 tcatcattac ccagcatcat gactttgatt gtgggtttaa tatccgtaaa tatagaaaca
     9241 agagggatag ccagtatacc gcttgtccct ggcgccaagc aaaactagcg aagtgctcga
     9301 ggttgtccac catcatcgaa acagatgctg tagaatcgtc aagagtatac gttacgttag
     9361 cagcaaacca gtagtcaata acatggggtt agggccatat ccaatatatt tctgggactg
     9421 aagctttgga catatagtat ggaatctaac cgaaggtcgc atactgcatt gtctcccatt
     9481 tcattttccg atgatgtcag gcatagccta agtaatgtat tcaaagctta tatacctcct
     9541 tctcaaaggc aaacgacaac atcatctggg gatttaaatg tagcaaaaat actcgctagg
     9601 cacaagaagc tagctagtac tggagtagta gtagtagttg ttgttgttgt ggccccctgc
     9661 ccaatcaggt aaacccgctg acaacgtgac aagcaccgtg caacctccag cacttcttcc
     9721 ctctcttcac agcaacgcat ggaatactgt agttgtttac tacaatacgt ctatatcgag
     9781 ttatagttcg ttcataattc ttcattaatg gccgactatc accagcgcta tactaactgc
     9841 aaaacaaact attaccatgt ccagattgga tacccacgct gaaaaccagt cacccgcaac
     9901 agagacaaac gccaataaat aacctgggaa taaaggaatg gtcaccataa aacgcgcaaa
     9961 cacctcgcaa atttgggttt gatcaaggaa aagctactgt ctacgccata gacagcttga
    10021 agtcggcgtt gttgccccgc acagtcacca ttccggtctt ccgcacttgg tcgtttgctt
    10081 tcccaaagta tcgcccggac cggaagctat ggcatcatcg tgagtatttt gggtaacaaa
    10141 gatcgctagt caacacctac ctccagtgaa gattagcgcg aacgacattc tgcacgcctc
    10201 ggatgtattc ttgaacatct gcatcgaccc gttcccccca ggttggcagt gctgccaaag
    10261 caaggtacca gtctcggtag cgctcaatga gcatttcgcc gacatgatta aacgctacct
    10321 gcgctggcat gccattgtga cggcagatgg ccactaagtt atggctcaca ccttctttct
    10381 gtattctttt gtaagtcatg cgggtcagag ctggtatttc aatgtagaca actaacctct
    10441 tctttgcagt atgatagtat gtcgttttgc ctaggatacg ttagtgaatt cagatgttgg
    10501 gtgatgtgtt ggggcagcct acagtaacac gaggtcagta ccaatcctct cgatctcttg
    10561 gatgctcttg cattcaaaca catgatctgg gatatctagt ttgtgggcat atctgcaata
    10621 tccctcaagt tagtgtcatt cacaggcaag cagacgtcat aacatactct actaaggcaa
    10681 agagcggcga aacacctgca gactgcctac gcagacagag catttcttca agcgagggca
    10741 actctccctt ggagcatgag cgtacttgag ccaagcatcc ggtgcagtag tcattcatgg
    10801 cacgtgcaaa cctgcgacga atcccttaaa cgacgttagc agatacccta aagtgtgtag
    10861 aggaatccca gcgctacata ccgataggtt gagcctgcaa taccgtcaga cgtcaatatg
    10921 cactcccagt acagtataat gatcaacgta cctgagtgat tcggtgccat actgagttgt
    10981 gcacctgtac tattgggtaa tctgagagta ctggcctctg cccagcttcg tcggccatgc
    11041 ctgctcgcaa atcctcaaca agtatttggg cacgttctgg gtcgtccttg aggcttccat
    11101 tatcgaagac tagaatcgaa gctcagtcat cacacagaag ccttccaaga gagatggtgc
    11161 ttacggtcat caaaagggaa cacctgcttg ggaattaatg gttagatcta gtcagtggaa
    11221 ctttatgcgg tcggtcgtgg ttatgaaacg cacccagttt ccccagtcaa taactgtccg
    11281 caactcttcg ggctcagcat ctggagctgc gatggaacag aaataagcga agtccgtctt
    11341 ttgtagtcgc cttcggcctc tttcatcaaa gtagcattcc ctgtcatggc ggtggctagg
    11401 ttagagaaag gtgatgccca cattaggggg cgatatgcac ctagagatcc atgcttctga
    11461 cagctctttc acagacttat agtgccgatt tactataggt tcgcccgaca agaacaacac
    11521 gaacatttca gggaggcgga tggtgagaga agtatcttgc cggggtatct tgactgttgg
    11581 cgaagatata ctctgctgga ctcttgtgac ggccatgttc gactgatagc gactgttaga
    11641 actgcggtgg ttcgagcaca atatagaaga atttaacgga tcgatcacta tatacatgaa
    11701 aacgaggtgg atctggacag caccacgaca tgtgccggtg catggtactt tatatacaga
    11761 cgaatgctac gacctgagtt caccaagcct ggaaccgtac gaatggccag gatgatccta
    11821 caactgacct ggctgtacaa ggcccagact tcgggctttg gtgacgacct gggcccacag
    11881 gatcgtccag cctcaggatc tcgtttcccg gtactcgaat ttcaatggcg ccagacaaaa
    11941 ggataaggtt tcagttggta acctgcaata cccggaagtc agaaaaaata ataatggcgt
    12001 ctgttataca tcaattaagg actgcaaaag tctagcgcta ctcagcccga ggagctagtg
    12061 cctggatgtt ctccgccgcc gccggagctg aaggcttctc aagagcaatg atcggtcgtc
    12121 caccaaagcg cggtatggat ttgacgatcc ctgcccgaat acgtctagag cacccattta
    12181 cggcctctgg atcttggctt ttgatcggcc cggaagccgg atctctcccc ggtatccggg
    12241 atttagcacg gtctctccat cttattcttg gcgacctctc ccgggggatt ggctaacctg
    12301 catgctagga cgattgggca gtcatgacaa cggggcccaa gacattgatt agcgcctcta
    12361 agttcgagac tggtacattt tgttgctttt tcctttgctc ttgattttct cgccggctct
    12421 gtccattgat caccagtctg gccatggtgg aacgagtaca tctgatcgtg atcataccat
    12481 tgggccactc tgctggggca ctgcggtggg tcccacgagg tgtctcgcct cgcagccacg
    12541 ggactgggct cgaacatccg cccggagcac gatgcatcgt tagtagcttt cactagagat
    12601 catgtcccaa aaggacgggt gaacgtgagg ggcggcccag gacccaattg cttttgtcag
    12661 gtaacactgg cggaaggcag gtccggtaca tggagtggcc attgctttcg ttcagctcca
    12721 tgagctctac agtccgtcga atcctagctt ggtatcttga attgcggtat aaaatgcggg
    12781 tgaagggcgc aatggaccaa ctatcaatga ctaggcattg gcctaacaga cacctcattt
    12841 cagtcaatat tggcaagcat tgctcgttaa ctcatcaata tggcctcttc ctcccaacca
    12901 caggctggcg acagaatcag tagctggggc tactccttct cctggacaag ggatcatctg
    12961 tccagggaag agttagagcc gttgcgccag cagtatgata cctctgcggc taacgcgctg
    13021 gagaggctac aagcaattag ggctacactg atggaagaaa gcaaagcaaa ggggacgagc
    13081 ccaccaccta gtgatcttta cgtcctccta cgggaccacc ggggggatga cgatatctta
    13141 gccaagttct ggaccgaagt gaacactgtg cctgagtggg tggactggga gcagctacaa
    13201 cgtggccagc aattcttcta tcgctatgcc attgccaata ttgtggggtt cgctttgcaa
    13261 gggtttgtgg cggaaaactc ggtatgttct ttcttgcaca accataggcg agggacgagg
    13321 gatctaatga tgctcatcag gctgcacctg gggttatcga ggtccttgtc cgaacaggag
    13381 gcttctccac ccgtatgctt ctgggcagat tgcttgagac ctttcagtgg ctaatccaag
    13441 tcacccattg cattacatca attcgccccg gcggcgaagg gcacattgcc agcgttcggg
    13501 tcaggttgct tcatgcctcc gttcgccaac gcatcattca actctgtcga gccaggccgg
    13561 attactttga tctggcacgc tttggagtgc cggtgaacac cctggactct gtccactcaa
    13621 tcagcacctt ttgttgcaac cctatgtggc ttcaactacc caagttcggc attcagccta
    13681 ctccggagga ggtcaaggac tatattgcgc tctttcggta cctaggcttt ctccttggaa
    13741 cgcccacatc gtattttgaa acggtggagc ggagtaaatg cactatggaa agccttctcg
    13801 cgcacgagct ccgtaccaca gatacgtcgc gaacggtggc gttcaacttt gtggaatgcg
    13861 tgacgaactt gccagggcca ttcaaggtct ccaagggatt cattgaagtg ggcagccgat
    13921 ggatcaatgg tgacgagctg tgtgatgaac tggaacttgg caaaccaggg ctcctgtttt
    13981 atctggcttt ttgtgggtat tgtgcactag tggtagctat ggcgtgggtc cagcggctat
    14041 ttctcagtct ggatgaacta ctgattgctg taaggtggaa tcttatcctt cacggtgtgc
    14101 acagatacta actctgggca ggggttccga agtttactgt atggtggagt ggtccagcga
    14161 aagtcgcgca ctcgattcga gttcagatat gtgccccgaa tcggcaagca gacggggaaa
    14221 gaagcataca gggttggtga tgcggccacg acaaaggctt cctggattta tcacccgatg
    14281 tggacgattc cctttaaatg cttgggagtg ggcctctttg agatggtgct tctcgtgatg
    14341 cttggtgttt ccggggtggt gatagtggga ggtgcgctca gagtcatgca gggggtgcat
    14401 gggtattcca aggcgtatgc ataacatgct ggacacagtg atgacgggtt catgcgagat
    14461 gattaggatt atgttgactt tgattcttac aattcatgat aacaaccata tgaacgatgc
    14521 ttatggtgta taccctggtt aattcgtcca ttgagtgtcc gacatgtaat tgaaagggtt
    14581 cgtatgagtg agtggtaacg ttgaagctgc cgcgtgattc gcatagatcg catttgaggc
    14641 aggtgaccag actggcaaag tcgaaaatcc caacaaagga accctggacc ggcagtccag
    14701 gcacgaccgt gccctcccaa caagaagcaa ccgggaggga aagagcgaga gagcgacata
    14761 gcaggagatg gatactttcg ggcttagaaa ctagtactta gttcgttagt tcttgatctg
    14821 atcgctggcc caaagctaag gatacactaa gagaaccgtg gggtaagatc cctgccaact
    14881 tgcatctggc ggcagatcct tcaatgtctc cctcttaagt agaaaaaaaa gcaaatccat
    14941 gcgccagtcc ttcagcgctt cccggttttc gtcagacgaa gcgaaaaata agaaattaga
    15001 taggaaatgg aaaaaaaaaa attcaaaaaa aaaaagcaaa ctacaatcct ccggtaaatc
    15061 gccatctttc ccgctcccga tggcgcccgg agagatccca aaaagacgat gtatcaattc
    15121 tgtccatccc agtgtgcccg atagagacgt actttttcga tgattttatc ccatcatgag
    15181 atacccactg gtcgatagta gtctagtagt acttagttga ctcccgagag gaaatgaggc
    15241 gcactaaaga aggcccgatc cactcggaaa cttaatcccc ctcgtgctgc tgctgctgct
    15301 gcttcggttg ctgttttgcg ttgttttgtg tctgtttctg tttctggttt tccctcaaag
    15361 tacaatctga gggcttgtcg gaggttcctt ccggagtgat gatgatgtat gccttccttc
    15421 tactaccttt cctagcaaca agtacgactt cgcctccatt tcagtcctat tattcagaga
    15481 gtgtctgtct gtctgtcacc gactccccag ctgggataaa tatagtatgt tcacaaagta
    15541 ctgtctacac cggtactcat gtgtctccac ttgtttatcg gtctgtttgt tggctgtggc
    15601 aattcctgtt cttggaacac tctcctctga ccccaaaagt acaatgtact tcgatatagt
    15661 tgggtgggta taggttcggg tacttagtga acctggttac tttcatacac ctggaaactg
    15721 aacgaaggtc ttgcctatcc tggataggat gtaaataagc cttgaatcat atttcatcca
    15781 gccatccgag actatctcgt tcattttctt tcccggatag gatcgttgcc gagatgacta
    15841 ctaactatta gttactattt ccgggactgg ggggccctat ctgccgcacg attaggttat
    15901 agtggctgag gtggcgcagt ggagatccct ttccattatg ccgtatgttt ctttgtgaat
    15961 attggaaagg aggtggtggg tgggaaggtt ggaggtgtta cgatccgtgc ggtgttattg
    16021 cagtctagcg gatggatgat ggatgataag atgggatgaa ccttgctgcc ttggtaggtg
    16081 gaggtgtggt gggggccatg ggtgtgattg atcccaaagt ttagagacgg atacaagata
    16141 gcatgaggct tagtactcta agcactacta tactactaag tcagtcacaa ggccagcatg
    16201 gtctgttttg tggctacagg ggatcaatgt agacgcatgc ggaaacagag aagttagtct
    16261 agcggagaca catagtaaac ataactagcg gagtatagat agacgatggt ggtgattcat
    16321 gtacgagaca accgataact agtagtgtgt tccggacaaa ggggaatgaa tggaaatggg
    16381 caagatgaac tgtatactag tatcatgtgc cacgtcgagt tttgacttga ttcaggcaca
    16441 tttccacttt cttcttttat tttcgtcttt tggagcagtt tagttagttc atatcccggg
    16501 tacaccgcag gaaactctcg gtactgactt acttccttca gttgagtcta caatatgtat
    16561 gtatctcctt atggcaagtc agtttaaatt gtagtacttg gatatcccct gtcagattcc
    16621 catgtcaagt catgatagtt tgggggggcc ggaaagaacg tgtcgctttc atattgattg
    16681 gggtttctgt tcggtcgtct cgggacccat ttctagccca gattccccgt ccaggatatc
    16741 cctgacaaag aaagaaagcg aaaagattga gggatcaatg attactctct tgggatgcgt
    16801 acagatgtgg ttccagttta tattttcttt tttccccttc ttccttgttt tcttttccct
    16861 ctcggtcctc tttcggctct ctttcggttt ttggttccgt gtgtggtgtg ttgtctctga
    16921 actatgcgac ttgcagatag atactcgtag ttgtagtagt agactttcgg gtgatgatga
    16981 aagcggatat taagaaccac caccagacaa agagaagtgc tgtgatcgtg atcgtgatcg
    17041 tgatcgtgat cgtgatcgtg atagtgtgtg atctgactga cagctgccag ttggcctgaa
    17101 tgactgatgg gacgggccga gtggagttgc cagcatgctt catttctttc tttcttcggt
    17161 catctttctt gcttgcttgg tcgttattgt gtgacatgcc tggtttggga atgtctcagg
    17221 attacttttt ccccttcatg ggctgatttc attttctttg ttcaatttgt gcgggaatta
    17281 ggggatgtgt gctatactat aatgctgtga ttatggttct ggggttggaa tcagttacac
    17341 tcctgatagt agatgccagt tcatgcagta agtgcattgg tggattcagt gaggctgaaa
    17401 tagtacatac tagcatcatt tcataaacag gactggtata cattttctac acaaaatctg
    17461 aaaagtgcca gttactagta gtagtagtag tagtagtagt agtagtagta gtagtaggca
    17521 gcagggggtg tgaatcccag tccagaggat gctgagatag tgagcacatc ttgctcaaga
    17581 gcatctctca gtatctttta accttctagc cagtccttta cagtaaagta cgctgagaat
    17641 catcataatc cgaaggtgtc catgtcgcta gcatgctgtt ccataggtgc ttggagagaa
    17701 tgtccgtcta attgagaatg cccgtctact agatcagatt tctcgaattt ggccttaaag
    17761 tgcctctgtg tgagcatcaa tgactcattt ctgtgttgcg aggctgaagt accagaatat
    17821 acaagacctc gctgacggat aagcgtttgt ttatttggag tcacttcatc ggatgtggtg
    17881 gtcgaaatgg ttgatgcact tcaacttctc agaagtcatc cttcccaagt ccatatttct
    17941 cttctatcct agtcagttat tttatttggc ctgtttctcc ccatgagcaa tttgtagcag
    18001 caaatacaga gtagacgaac tacacgaaga ggcagtgaaa tcggcggggc agcaacacca
    18061 gggcggcccg tgcaaagaat ttctccagag ctcggccggc tctccctctt cctcccacaa
    18121 cttccctcgt ggcctttctg cctctctacc ccccttttcc cccatcccca ctatcaaatt
    18181 tctttcgcac aatggcaatc cagtgagtct ctcatcggct actgaattgg ccggaaatgc
    18241 gctgaccttt gttttccgca gctacttgat tctcctgtcg aggcagggca aagtggttcg
    18301 tttcgtggcc cacccaactc tgtgacctgg ctggaagcgg agactaacgc aacaaaattt
    18361 cccagcgcct tgccaaatgg ttcaccactc tctctcccaa ggagaaagcc aagatcatca
    18421 aggatgtgac ccagctggtt ctgtcgcgtc gcacccgcat gtgcaatttc ctcgaataca
    18481 aaggttcgtc ggaatcggct tcacccctca cttggatcct ccccgcagct cgcccaccag
    18541 ccccgatcgg actgcatctg acttgcttcg tcttcgccag acaccaaggt cgtctaccgt
    18601 cgctatgcct ccctcttctt catcgccggt tgtgcgtcta ccgataatga attgatcacc
    18661 ctcgaggtcg tgcatcgtta cgtcgagcag atggacaagt actacggcaa tgtctgcgag
    18721 ctggatatta ttttcaactt ccaaaaggca tacttcatcc tcgatgagct attgctggcg
    18781 ggagaaatgc aggagagcag caagaagaat gtattgagat gcatcagcca gcaggacagt
    18841 ctggaagaca tggaggtgag tcgatagcgt ctattgcttc gtgacaccct gcacccccta
    18901 tttggaacat gagcacggag taccggcatc tggagcgtcg aatcgctaca ttttcttttt
    18961 ttcccggcgc tccccttttt atacctgcga tgtcccgaca tcttgatcag ttcctgcgat
    19021 aacctccttt ctcccctctc cacaacatcg tttctcccgc cctgccccct tcctcaacca
    19081 attcctccat tcccagcgag ccataccatc atcttctgtc gacgtcagct aatgccgcct
    19141 caggttgagg aagacgtggt cacgaagatt atgtagacgc ctctccggcc cgcgagcgtt
    19201 tctttgttgt ttatactgtt tgggatgttc gtttctgttt tcggggcaag ctggactgct
    19261 atacatactg gcgttggacg tacataagcg ttgtgttcta ctgtctcgcg acttgttgcc
    19321 aagaactaat taataccacc ttgactacat tcaggactcc aaggaagtcg tcagtcattt
    19381 agcgaaagaa gggctcctgt gaggggattc acaagatgga gggatcgtca gggaggataa
    19441 tggatgattc cacactttgc ctcattctct gggctggtcg gccatccttg gttcagtgcg
    19501 caacccgtga ggtgggtgcg tgatatcact ggcccgacct gcgccacgtg actgggggct
    19561 cccccctcgg ggcgcagcgc atcccccatc cacccccccc caaagaccag tcgctctatc
    19621 gcgctgtcca tctcccattc cttccctgag ccttcttcca tctccttccg tctcatctgc
    19681 atctgctatg gcgacttggc tctccatact cacctaataa ctcacccatt cttcgttcct
    19741 gtgctgccac cgtagcaacg gttccacccg ccagctcatt cactcttatc gccggattcg
    19801 tgacgtctca ggagacaacg gccccggttt atttgaaccc aactgctgcg acaattgctc
    19861 tcatctgctt gtcgcatcac cttgtgtctt gatcactgac cacggtgttc tccgcttatc
    19921 tgtaaagcgc ttccttatcg taatcagcga cttctacacc gcaactctgg ctgaagatga
    19981 aggtatggat cctagccctt ttgcgccgct gcagcctcgg atagagtggc ctgatgctta
    20041 cccgtgtctt tccctttcag tttctgccat tgcccgaatt cgaagacgtg acgagttctc
    20101 tcaatttcga cactgccgat tgccacattg tcggaggatg cgatctgtac accacaaagg
    20161 ctgctcgagc cgatcggaaa ctgtacaaga acattgagca gtcgcttgag tcccaatatg
    20221 aatcggttct ccgcctgtca gcttcgctgt cacctcccaa cgcatcggac gcggctgcct
    20281 cgctcaatct atctcggtcg agtccgttcg gtcccctgag cgaccattcc agtcgacgaa
    20341 catttgccta tttgatcgcg acattaaatg ccagtcatcc ggattatgac ttctcccatg
    20401 tgctgcgccc atcggacttc catcgtgaac ggaatctgaa gcgagttatg aacacgatcg
    20461 attcgacact gttcaacctt cggccacgtg aggcaatcga tctgacacct ccatctcccg
    20521 tgacgatctc gggttcctac aatgcgggcg cgtcttctac gtgggggccg agaatgtgga
    20581 gagttatcga tgaacatatg tctctcaagg agtgctccct ctattcgttt tcgccggatg
    20641 aggatccgtc ggatgcggac gatggagcaa tttggagtct tcattacttc ttttttaacc
    20701 gactacggaa acgcgtctgt tatctgtatc tacgagcgat ccctattctc agccacacgc
    20761 ccagcgaggg acttgccacg ccgacgacga agagaacgta tgacgacgga tacctgacac
    20821 cggaacttgc ctcgagcaag cgggctcgct actggctggg tgagggcgtt gaactcgaga
    20881 gcgaaagcga cgaggaagcc agtgggtcga agcccacgcg tccagtcgtg gacgaatacg
    20941 accactacct gctcagcgat gaggagttcc ggtcccgatc gggcagcaag ggcaccgttc
    21001 gggccatgag cgaggaaatc gctgactcga tggaggtcta atcctccctt cccttctatc
    21061 ttgactgttt attttcacct ttcaaccaac ccggcccttc tcgtttgcca tttggccgtt
    21121 ttgttcagct gcctattctc gtttggttcg actgctcggc gtaattgttt tcttgtctgc
    21181 tgcattcaac ctgcatttgc accggctagg ggcgttatac tcggtaaccg gaaggaaggg
    21241 aaggaatgcc cctaattgta attgaacggc tgttggtcta atgatgatga tgacgaacga
    21301 cgtgctgcgt cacggcaatc cgatgcggcg ctcaagggca ggttccacaa cggcgggcgt
    21361 tgtcattctt ctgtttcctt cctgtactta ttacaaattg atatttttga ctctgtgact
    21421 ttatcacgta gacggttaga cagaagaaaa tgctatttat agatcagacc agctatttga
    21481 tagttaaaaa acagtgcagt actgtatcat tgacgagcaa cttggaactc cccgattggt
    21541 ccgtgcaccg cggccaaagc tgtcctccga tccgactatc accaagtaga ccatctatca
    21601 tcatcaacaa tccacc
//
