LOCUS       KZ851909.1             21400 bp    DNA     linear   PLN 20-AUG-2019
DEFINITION  Aspergillus niger.
ACCESSION   KZ851909
VERSION     KZ851909.1
KEYWORDS    .
SOURCE      Aspergillus niger
  ORGANISM  Aspergillus niger
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Eurotiomycetes; Eurotiomycetidae; Eurotiales; Aspergillaceae;
            Aspergillus.
COMMENT     'Annotated using funannotate v1.6.0-df4262f'.
            ##antiSMASH-Data-START##
            Version      :: 5.0.0
            Run date     :: 2020-11-02 07:38:58
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 829728
            Orig. end    :: 851128
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..21400
                     /aStool="rule-based-clusters"
                     /contig_edge="False"
                     /core_location="join{[<839728:839886](+),
                     [839927:840289](+), [840347:840504](+), [840560:840650](+),
                     [840701:840735](+), [840791:841003](+),
                     [841055:>841128](+)}"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      join(<10001..10158,10200..10561,10620..10776,10833..10922,
                     10974..11007,11064..11275,11328..>11400)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     cand_cluster    1..21400
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..21400
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="4"
                     /rules="(Terpene_synth or Terpene_synth_C or phytoene_synt
                     or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps
                     or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /tool="antismash"
     mRNA            complement(join(634..2197,2267..2697))
                     /locus_tag="M747DRAFT_277786"
                     /product="Metallo-dependent phosphatase"
     gene            complement(634..2697)
                     /locus_tag="M747DRAFT_277786"
     CDS             complement(join(834..2197,2267..2399))
                     /codon_start=1
                     /db_xref="InterPro:IPR004843"
                     /db_xref="InterPro:IPR008963"
                     /db_xref="InterPro:IPR015914"
                     /db_xref="InterPro:IPR025733"
                     /db_xref="InterPro:IPR029052"
                     /db_xref="InterPro:IPR041792"
                     /db_xref="PFAM:PF00149"
                     /db_xref="PFAM:PF14008"
                     /db_xref="PFAM:PF16656"
                     /locus_tag="M747DRAFT_277786"
                     /note="SECRETED:SignalP(1-20); GO_function: GO:0046872 -
                     metal ion binding [Evidence IEA]; GO_function: GO:0003993 -
                     acid phosphatase activity [Evidence IEA]; GO_function:
                     GO:0016787 - hydrolase activity [Evidence IEA]"
                     /product="Metallo-dependent phosphatase"
                     /protein_id="ncbi_M747DRAFT_277786-T1"
                     /transl_table=1
                     /translation="MSKLLALTKVLPVLAVGSLAVDYPTIPKDKTTPYQQRLAIYGPNA
                     VSVAWNTYEQLNQSCVEYGTSSSNLDSKACSTKSTTYSTSRTWSNVAYLTDLTPATTYY
                     YKIVSDNSTVGQFLSPRTPGDTTPFSMDVIIDLGVYGTDGYTLSSRKAKKSDIPQVEPD
                     LNHTTIGRLADTIDDYELVIHPGDFAYADDWYEDVGNWLDGSDAYQSILERFYDQLAPI
                     SGSRLYMPGPGNHEADCSEIPYLNALCPEGQKNFTDFLHRFDATVPSAFASQSTNTTAQ
                     ALAEKARSLAVPPFWYSFEYGMVHVTMIDTETDFKEAPDGTDGSADLDSGPFGFKNEQL
                     EFLEADLASVDRTVTPWVVVAGHRPWYTTGSGNACDVCQEAFEDIFYKYGVDLGVFGHV
                     HNSQRFQPVVNDTADPNGLNNPKAPMYIVAGGAGNIEGLSSVGTEPSYTAFAYADDYSY
                     STLRFLNSTALQVDFIRSTTGETLDSSVLYKDHSTQFVVQ"
     mRNA            complement(join(2985..4063,4123..4252))
                     /locus_tag="M747DRAFT_294729"
                     /product="NAD(P)-binding protein"
     gene            complement(2985..4252)
                     /locus_tag="M747DRAFT_294729"
     CDS             complement(join(3116..4063,4123..4194))
                     /codon_start=1
                     /db_xref="InterPro:IPR008030"
                     /db_xref="InterPro:IPR036291"
                     /db_xref="PFAM:PF03435"
                     /db_xref="PFAM:PF05368"
                     /locus_tag="M747DRAFT_294729"
                     /note="EggNog:ENOG41"
                     /product="NAD(P)-binding protein"
                     /protein_id="ncbi_M747DRAFT_294729-T1"
                     /transl_table=1
                     /translation="MTGEYVKDQPAGFSNRIQRIAIVGAGGTVGRPITEELLRTGQHSV
                     TALTRIGSTSQVPSGVQSIAVDYDDEASLVRALQGHDCLIISLSVQTPRDTQPKLLQAA
                     SQAGIRHVMPNVWGCDVMHPPLADSGLNWGGFRELVAGIEAKGMGWTALICGFWYEHSL
                     VLGPSAFGFDLPAKKLILNDDGNTKINISTLAQCGRAVSTLLSLPVLPEDEQDDQLTLS
                     RWRNKPVYISSFLLSQRDMLASWLRVTGETADSWTIEQESSQGRYERGLELMKKGDHAG
                     LLLAMYSRVLFPNGDGNHEQRRGLDNDLLRLPTEDLDEHTRQAKAMSDRGYNYMTNRN"
     mRNA            complement(join(5108..5648,5710..5807))
                     /locus_tag="M747DRAFT_277790"
                     /product="hypothetical protein"
     gene            complement(5108..5807)
                     /locus_tag="M747DRAFT_277790"
     CDS             complement(join(5220..5648,5710..5769))
                     /NRPS_PKS="Domain: Polyketide_cyc2 (0-146). E-value:
                     6.5e-08. Score: 24.8. Matches aSDomain:
                     nrpspksdomains_M747DRAFT_277790_Polyketide_cyc2.1"
                     /NRPS_PKS="type: other"
                     /codon_start=1
                     /db_xref="InterPro:IPR023393"
                     /locus_tag="M747DRAFT_277790"
                     /note="EggNog:ENOG41"
                     /product="hypothetical protein"
                     /protein_id="ncbi_M747DRAFT_277790-T1"
                     /transl_table=1
                     /translation="MYTITTSVEIAAPPGVVRDKFLDFAALPTYSPSGFIQHISSVTDK
                     PPTHLQAGDRLNCTVNYGKTHFTPIVKANTPALFSWVGSIPGIFTGEHRFSFESIDADQ
                     PGKPYRTRLVHEERFTGLLSFLMGQGMLANAAGWRENTRQGFDTFNRDFKAWVEASWR"
     aSDomain        complement(join(5271..5648,5710..5769))
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_M747DRAFT_277790_Polyketide_cyc2
                     .1"
                     /domain_subtype="Polyketide_cyc2"
                     /evalue="6.50E-08"
                     /label="M747DRAFT_277790_Polyketide_cyc2.1"
                     /locus_tag="M747DRAFT_277790"
                     /score="24.8"
                     /tool="antismash"
                     /translation="MYTITTSVEIAAPPGVVRDKFLDFAALPTYSPSGFIQHISSVTDK
                     PPTHLQAGDRLNCTVNYGKTHFTPIVKANTPALFSWVGSIPGIFTGEHRFSFESIDADQ
                     PGKPYRTRLVHEERFTGLLSFLMGQGMLANAAGWRENTRQGFD"
     mRNA            join(6220..6519,6605..7626,7680..7812,7861..8070,
                     8106..8282,8339..>9014)
                     /locus_tag="M747DRAFT_349143"
                     /product="hypothetical protein"
     gene            6220..>9014
                     /locus_tag="M747DRAFT_349143"
     CDS             join(6386..6519,6605..7626,7680..7812,7861..8070,
                     8106..8282,8339..>9014)
                     /codon_start=1
                     /db_xref="InterPro:IPR007219"
                     /db_xref="PFAM:PF04082"
                     /locus_tag="M747DRAFT_349143"
                     /note="EggNog:ENOG41; GO_component: GO:0005634 - nucleus
                     [Evidence IEA]; GO_function: GO:0003677 - DNA binding
                     [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding
                     [Evidence IEA]; GO_process: GO:0006351 - transcription,
                     DNA-templated [Evidence IEA]"
                     /product="hypothetical protein"
                     /protein_id="ncbi_M747DRAFT_349143-T1"
                     /transl_table=1
                     /translation="MSLGSIRGTAEDLMFRPCPPHPEINDPFGSMLPRPASPVVMGKLR
                     NCAIRGKTCRYRQSDDKRKVPVRPAVAVLARRVDSLVHHIRECGLPVPPIDEEDHRILK
                     NVLDALELRCEDVVADPNDTSSRPGLANILPTTPVSVNSSAPPTQPNETDSVGPSHQPS
                     VCLEPLDLSFDKERVAWKDSTISEAPREEEEEVGDSDDEVTDQLSCRLGRLQVTHDGQL
                     RYFGSTSNLTLLDALVDVTPPVAIPRDAPELLENAKLNQEVDEAFEKHLIDLFFAWQDP
                     SLHVIDAESFWRSRAQSREEGLATPYYSRALSDAMCALGAAYEPKYHPDFVTFPRSLAE
                     FFGDRAKLLVELELDNPSIATIQALVILSNHEASCTRDTRGWLYSGMAMRLTLDLGLHL
                     EMGPYVEKGIIPHQDAEVRRMVFWGVYLNEQFWGFYLGRSAQCRMDAVTVRKPMSPSPV
                     PTSSWKPYPDQLGTSFPQIPFNPLCQEWVSLYEIMLPLTDVLANGYLPRYGCSEISTHS
                     LQELASVTVEKLQQWHLNLPVELKADEGTTFRSPLPHVLTLHMQYYQFMIHCHKPYISR
                     RHIQPQPPQGPGSGHARRMCIESAVAIVQLLDLYERSYGFDKSSIQMVSFVFSAALILI
                     FNTIPAKTTSQDQHLVIHLSTCFRALDRMASCFENARRTSVFLGTLRQQWQVRRQKRRA
                     RAGRVNFAYSRKLDLSESAGWNRDGSEAYSSVQCQPAVTESSVTGLDTELSDLVPYYSA
                     IADAPASTVDFMGPNLCNILLSEGIPRAFV"
     mRNA            join(<10001..10158,10200..10561,10620..10776,10833..10922,
                     10974..11007,11064..11275,11328..>11400)
                     /locus_tag="M747DRAFT_349150"
                     /product="terpenoid synthase"
     gene            <10001..>11400
                     /locus_tag="M747DRAFT_349150"
     CDS             join(<10001..10158,10200..10561,10620..10776,10833..10922,
                     10974..11007,11064..11275,11328..>11400)
                     /codon_start=1
                     /db_xref="InterPro:IPR008949"
                     /db_xref="InterPro:IPR034686"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: Terpene_synth_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052:Terpene synthase/cyclase metal-binding domain
                     protein (Score: 130.5; E-value: 1.5e-39)"
                     /gene_kind="biosynthetic"
                     /locus_tag="M747DRAFT_349150"
                     /note="EggNog:ENOG41"
                     /product="terpenoid synthase"
                     /protein_id="ncbi_M747DRAFT_349150-T1"
                     /sec_met_domain="Terpene_synth_C (E-value: 3.5e-15,
                     bitscore: 50.5, seeds: 87, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MENKLSPQDVILQKLYGHTCVIPDLRSFMKSESGGINKHRTLLPL
                     CVYDYIDSQADASESLSLLPEDPAKAQKVKGADFPLLACLWWPHASFRKLRVLAFLVVW
                     LIVWDDELDGASQFTAYDLNMGQQFRDETRRFVKASLGLESEDPNNVTKNAIIRGFSPI
                     ADSIREEYDEEHRLTLTEEIIFVIHMSKVEQENRLGMDIPSTDQYLAYRLGTNLMGVIC
                     AATELSMDWRIPRSITRSPWVKDVWHQTNLIIALTNDILSLKKEIDKGEVYSFIPVLLN
                     QNRTPQNAVDLSIQILQDSIADLDRIKSDIVASSDQTHSKFLVESCRRYCTGFLEWSLI
                     TPRYKLATVPRDQTGAMVLLF"
     mRNA            join(<12860..13155,13253..13530,13580..13950,14000..>14674)
                     /locus_tag="M747DRAFT_349153"
                     /product="FAD/NAD(P)-binding domain-containing protein"
     gene            <12860..>14674
                     /locus_tag="M747DRAFT_349153"
     CDS             join(<12860..13155,13253..13530,13580..13950,14000..>14674)
                     /codon_start=1
                     /db_xref="InterPro:IPR002938"
                     /db_xref="InterPro:IPR036188"
                     /db_xref="PFAM:PF01494"
                     /gene_functions="other (smcogs) SMCOG1087:hypothetical
                     protein (Score: 221.2; E-value: 4.3e-67)"
                     /gene_kind="other"
                     /locus_tag="M747DRAFT_349153"
                     /note="GO_function: GO:0071949 - FAD binding [Evidence
                     IEA]"
                     /product="FAD/NAD(P)-binding domain-containing protein"
                     /protein_id="ncbi_M747DRAFT_349153-T1"
                     /transl_table=1
                     /translation="MPTKDLKVVIVGGSIAGLLLANALARQGIDFIVLEGRSEVAPCDG
                     AGLCILSSGARILDQLGIFEDIQAYGGPISVQRIWRDDGQLLGHTETLALIPVRQGYPV
                     IFVERQRVLQVLFEHLPDTKRVLLGKKVIDITASDDQAIVKCLDGTNYEADIIVGADGI
                     HSITRRKMIRDIISNCPQSHISHGQLRRVFTAQYAAVFGLSRPTPGMKIGHCNRTFADG
                     FSFFNAVGRKGQIFWFLYRDMGKVYSEKDIPRFDQNKIEEDIAPFLNKYVAEGVRFQDI
                     FKNRVQCAHVPIEEGFLTQWAWGRYACIGDSVHKTTPNLGQGGNGAIESAASLANTIVS
                     IAHSVKLESLSVPEISASLDEWARSRQRRMKLICDLGNSFTRLEAFHTLKDKALGLYLG
                     KYQVDAIADILCDTTVGAEKLSFLPLPEKSAHVTMPFDPEKGIHAAPRVRSLMLRALLP
                     FILIFAVQPTVRGFMNSRILKPVSISYEHEAEAFDFLGYDINYQSIQALAAMSRIADLG
                     AILGIWALESCRTGNVATLMSL"
     mRNA            <14747..>15427
                     /locus_tag="M747DRAFT_314125"
                     /product="hypothetical protein"
     gene            <14747..>15427
                     /locus_tag="M747DRAFT_314125"
     CDS             <14747..>15427
                     /codon_start=1
                     /locus_tag="M747DRAFT_314125"
                     /note="EggNog:ENOG41"
                     /product="hypothetical protein"
                     /protein_id="ncbi_M747DRAFT_314125-T1"
                     /transl_table=1
                     /translation="MGIFEGTNIVVPLYFLLYAIQSPAAKFTAPDRRSTQGSYTRSLIP
                     CLILCYYIPGFWMVYNDSGVHSRLGWKFVLLSTLFRLSHVQVASLLRRTTVRELIETPD
                     ADMPYMRIAYYTCGLLSGAMSIMWRALASRSLYARSLPISQVLYQTTSPIHIDHHGMTG
                     CVCGLAWLLFEYKDMKLAKAIDLSWSCLILLGTLITLVFGLAAALMLGWGLREEYLAKY
                     AIQH"
     mRNA            <16472..>17242
                     /locus_tag="M747DRAFT_349156"
                     /product="hypothetical protein"
     gene            <16472..>17242
                     /locus_tag="M747DRAFT_349156"
     CDS             <16472..>17242
                     /codon_start=1
                     /locus_tag="M747DRAFT_349156"
                     /note="EggNog:ENOG41"
                     /product="hypothetical protein"
                     /protein_id="ncbi_M747DRAFT_349156-T1"
                     /transl_table=1
                     /translation="MRRPLVECEKALNRVCQRYQLFTPTNWQLLSVASGFLFVTILFLA
                     LIACGFIPPLPPSWGADKVYSHYHGHRKGIQAGAALILISSGLCLPYGAVISKQLRMIR
                     DVDPILCDLSLVACGVGSVSFMMSSTFLGLATFRDYGPELTLLLSDLFWFTIVMQWPPF
                     WIQCWTITWAILSDRSSNPAFPRSLAILNFIAPLALSSATAIHLYHRGPYAWNGALSFW
                     FAFVLFFAQIELDLITIGRNVLEHRRLEFNERTI"
     mRNA            complement(join(17675..18009,18078..18272,18346..18805,
                     18858..18949))
                     /locus_tag="M747DRAFT_277794"
                     /product="hypothetical protein"
     gene            complement(17675..18949)
                     /locus_tag="M747DRAFT_277794"
     CDS             complement(join(17716..18009,18078..18272,18346..18805,
                     18858..18940))
                     /codon_start=1
                     /locus_tag="M747DRAFT_277794"
                     /note="EggNog:ENOG41"
                     /product="hypothetical protein"
                     /protein_id="ncbi_M747DRAFT_277794-T1"
                     /transl_table=1
                     /translation="MYRPTTKYEWWLCGVLLTQAALTIISEVYILIEWQQWVTPTINQV
                     PVSYLIPINLGILIFACLFEFILSLDAMHHKNNILLFAVCICNACSFGYSVMQFIVMRD
                     TTARLFKTRFGYPTLVDTTRNVWPRVQPAEILVCIFTGFSALILCPIAYVIHRHYSWAI
                     YKSVHGSLDTRMRYLAYEIFLVLIKLDFYFLIGFIIQYDLVYVHFKEPEYTLTMVIIPA
                     AIIAIFLGVWFVQRERTIGAVAIIMCYLALIAYLISRIVILSSANTAGKSMMLFFASLT
                     LVLTAGTVLCTAICIKNFNRGLTTINQSKNANARESYLLYNRSPSAELSPGFPRSSSRL
                     TLD"
     mRNA            complement(join(<20116..20439,20503..>20841))
                     /locus_tag="M747DRAFT_304288"
                     /product="hypothetical protein"
     gene            complement(<20116..>20841)
                     /locus_tag="M747DRAFT_304288"
     CDS             complement(join(<20116..20439,20503..>20841))
                     /codon_start=1
                     /db_xref="InterPro:IPR012312"
                     /db_xref="PFAM:PF01814"
                     /locus_tag="M747DRAFT_304288"
                     /note="EggNog:ENOG41"
                     /product="hypothetical protein"
                     /protein_id="ncbi_M747DRAFT_304288-T1"
                     /transl_table=1
                     /translation="MSFALCARRSFRGPEASLFSKAVRTPKRDFRITAPAAIRVSELIK
                     NDHQELRGAYHQILSAQTNDDRVRWQNQFTWELARHSIGEELVVYPEMELKLNNGKAMA
                     QHDREEHQVIKELLYTFQGLQPDDTEFIPTLKSLWANLEQHIKEEESQDLPALESALGD
                     SASESMARSFGRTKNFIPTRSHPAAPDQPPYETVVGLMSAPIDRLGDMLRKFPDQKA"
ORIGIN
        1 ctcgagaccg accctcgcac caagaagtgg tcatggctct tccagggata cccgcaatgg
       61 catgctgcca tctttctcct tgagcagatt ggcattggac cacagacaat gctgactgac
      121 cgggcctggg ctgtagtagt caaagtcgtc acacgttgga gaaacaccga ctatcaaaag
      181 gacggggtga tctcaatctt agtctcccgg cttatggcgc aagctgcagt cgcacaggga
      241 tgcatctggg acgggagaga gagagaagac gggccaggat caccgcctga aaacctatcc
      301 tatagcaaga atcaataagt ctgttgaatt cttacatcat aataaaccga tattaggatg
      361 attataggtg tttgtctcgc tttgtatcct ggaagagacc aatgctgagc cacttgtccc
      421 ggtataaatt ggaccaaagt atatgcttca aaaatataat gagacaatga tcgtcaacct
      481 ttgcccatat gtgaccggca aataccccct atccaggcga ctttgagtga ggaagatggt
      541 tggcttccca cagctatcta gaagaataca caaatgcggc gatatctgac tcacgttgaa
      601 taccggccat tcagattcac aaggtattct aaagcactgt gcaggaagga agacagtatt
      661 aatagtaagt atctcgagac agtgggtcgc gccttccagt gagattgttg aatatataga
      721 ttatagtcac gatcaacttc ccgggctcag gagccatgtc aatcctcatt atatatacac
      781 atatctacaa cttcatcctc cccttcataa tttttccatc ctgccaaata cacctactgc
      841 acaacaaatt gagtggaatg atctttgtac agcacactgg agtccagtgt ctcgcccgta
      901 gtggagcgga taaagtcaac ctgcagcgct gtcgagttga ggaagcgcag agtactgtag
      961 ctgtagtcgt cggcgtaggc aaaggccgtg taggagggct ctgtacccac ggaactcagg
     1021 ccctcaatgt tgccggcacc acctgcgaca atgtacatgg gcgccttggg gttgtttagg
     1081 ccattcgggt cggcagtgtc attgaccacg ggctggaagc gctgcgagtt gtggacgtga
     1141 ccaaaaacgc ctaggtcgac gccgtacttg tagaagatgt cctcgaaggc ctcctggcag
     1201 acatcgcagg cgttgccgct gccggtggtg taccaggggc gatgaccggc caccaccacc
     1261 cagggggtca cggtgcggtc gacgctggcc aggtcggctt cgagaaattc cagctgctcg
     1321 ttcttgaagc cgaacgggcc cgagtcaaga tctgccgagc catcagtgcc gtcgggagcc
     1381 tccttgaagt cagtctcggt gtcgatcatg gtgacgtgaa ccatgccata ctcgaaagag
     1441 taccagaagg gtgggacggc cagactgcgc gccttctcgg cgagtgcctg ggcggtggtg
     1501 ttggtggact gagaagcgaa agcgctggga acggtggcat cgaagcggtg caggaagtcg
     1561 gtaaaattct tctgaccctc ggggcagagg gcgttcagat agggaatctc gctgcagtcg
     1621 gcctcgtggt tgcctggtcc cggcatgtac agtcggctac cggagatggg agccagctgg
     1681 tcatagaagc gctccagaat ggactggtag gcatcggagc cgtccagcca gttcccaaca
     1741 tcctcgtacc agtcatcggc gtatgcaaaa tcacccggat gaatgaccag ctcgtagtcg
     1801 tcgatggtat cagccaggcg gccaatggtg gtgtggttca gatcgggctc gacctgggga
     1861 atgtcggact tctttgcctt gcgcgaggag agcgtgtaac cgtcggtgcc gtagacaccc
     1921 aggtcaataa tgacgtccat gctgaaaggg gtcgtgtcac cgggtgtgcg cgggctgagg
     1981 aattgcccca cggtggagtt gtcggacaca atcttgtagt agtaggtggt ggccggggtg
     2041 aggtcggtca ggtaggcgac gttagaccag gtcctcgagg ttgagtaggt ggtcgacttg
     2101 gtcgagcagg ccttggagtc caggttgctg cttgaggtgc catactcgac acagctctgg
     2161 ttcagctgct cataggtgtt ccatgcgacg gagacagctg aatcatttgg tcctgaacgt
     2221 cagcggtggt tctggtgtgt tgaagacgga cagctgggtt cctcaccgtt gggtccatag
     2281 attgccagtc gctgttggta aggggtggtc ttgtccttgg ggatggtggg gtagtcgacg
     2341 gccaaggaac ccaccgcgag gacaggcagc accttggtca aggcgagaag cttggacatg
     2401 ctggcgaatg atcagtgcag atgtaaatct gattgacgcc cgtggaagac attccttaaa
     2461 agccatttca aggatgacgg tcgcaagggt atatatatgc tacttcagtg ggcagccgca
     2521 tgaccagaaa atgcgtctca ggactaacac gtgggagggg ataagataga tgcggagcag
     2581 tgaatgcaag gaatgcatcg cgtcaggaga gcttctcggc ggacgctgca gaatagggtt
     2641 atttggcagg caacgtgcgc cggcccgcac ttctgcttgg aacgcgagca gcaagagagg
     2701 ggctgctgtt catctccgcc tcatttaatt tcatttctgc aaacttgacg agcgacggag
     2761 agagagaacg agtgagaagc ttggatgaag gggttagtgc cgcacgtggg atcggccgcg
     2821 gctgtcactg ctcgggagga gaggccattc ggggagagac gaaccgaggc tattcccgtc
     2881 tgtcgatcac tctcggtcgg gagtccgtcg gcgatggact gacactcctg tttgggactg
     2941 gttggtttcg gctaccaatg ggagttattg accatcgtgg taatggtggg ttgcattccc
     3001 tctctggtta actatctact ggtactgaca agctgcatgc gaggtagtag tagtggaccc
     3061 catcacgcta gaaacgttct cacaggaaca gcacctcccc gaccatccac accaatcaat
     3121 tgcggtttgt catataattg tatccccggt cagacatggc cttggcctgg cgcgtgtgtt
     3181 catccaaatc ctccgtggga agtcgcagca ggtcattgtc tagcccccga cgctgctcgt
     3241 ggttgccatc gccgttggga aaaaggaccc gcgagtacat ggccagcagc aatcccgcat
     3301 ggtcgccctt cttcatcaac tccaatccgc gctcgtaccg accctgagag gattcctgct
     3361 caatcgtcca actgtccgcc gtctcgcccg tcactcggag ccaacttgct agcatgtctc
     3421 gctgactgag caggaaactg gaaatataca ccggcttgtt ccgccaccga ctcagggtca
     3481 gctggtcatc ttgttcatct tccgggagca ccggaaggct cagaagggtg gacacggctc
     3541 ggccacactg ggctagggtg ctgatattga tcttggtgtt gccgtcgtcg ttcaggatga
     3601 gcttcttggc gggaagatcg aagccgaatg cactcggtcc cagtaccagg ctgtgctcat
     3661 accagaatcc acagatcagc gcggtccacc ccatgccctt ggcctcgatg ccggccacga
     3721 gttcgcggaa ccctccccag ttcaggccac tgtcggctaa cggcgggtgc atgacatcac
     3781 agccccagac atttggcatc acatgccgga taccagcctg agaggcagcc tgcagcagct
     3841 ttggctgagt atcgcgaggg gtctgcactg acaggctgat gatcaggcag tcgtggccct
     3901 gtagagcgcg tactagactg gcctcgtcat cgtagtccac ggcaatggac tggacgccgg
     3961 aaggcacctg gctcgtactg ccgatgcggg tcagggctgt cacgctatgc tgtccagtcc
     4021 gcagcagttc ctcggtgatg ggccttccga cggtgccccc agcctggcaa tcagacttgt
     4081 ggttagtgat gtggatggca cagacgggca cagggggctt accccgacga tggcaatgcg
     4141 ctgaatacgg ttgctgaacc cagcgggttg atccttgacg tattcgccag tcatgacgaa
     4201 agacacagat gatttcctgt tgtttggata tactagtatt gaatggattc cgtatctgat
     4261 gctgttgtag cagccaagta gtaggtgaat atatactttt gagggattcc tcgccgtacg
     4321 agcgatcggg gattagaggc gttatctccg ccattgtctc ggcgtcaata cgtcgcccgg
     4381 agttagatga atcagcaact aaccttctct ccgatccccc ggagatatgt cacgcgaagg
     4441 ttccccagga agaagcaggc cgtggatgag tggacaccag cctgcgatcc tgcgatcctg
     4501 cgaccccggg agatacggtg accgattctc cgatccgcct gaagtcaagc gaatctcacc
     4561 tcatccaggt gcgatgggcg gcaggcttgc tgtgtttact tggcgatgat gtgaaatcca
     4621 tcctcaggtt tctaatcagt agaacagttc gtcaaaggat tatctactgg ttgctattgt
     4681 cgtactaacg taatcaacgg ttggacggcc cacactgttg ggcggcccat ctggaaatac
     4741 tataccaaag attctttctg gatatctcaa ctattgtatg tctagacaac tcaatattgc
     4801 ataaattgat tataagtaat ataaataact acttcaaact ttccaaaaat ctatgtaaat
     4861 gtatatagta tctcgtcata ttacgatata tatatttcat ctgtaatatg ggatatattg
     4921 atatatttta tacaagaaaa atttttcaaa atcaggaaat aatatatatc atttattttc
     4981 atgtatagaa cctatatgtg aggttagaac taatcagata tagtattaat cgagatataa
     5041 tggaatcaaa aagacatctt ttatatggga taacgagatg ggccgcccaa ccgtggatta
     5101 cgttgataat ttagttagtt aatcttgtgg agattactaa gtagggcatg attctggtcg
     5161 cccctacaag gcacaacatg acgctcctcc cctgttcggc cacagatcgt gtctatgaat
     5221 catctccagg aggcctccac ccaagctttg aaatctcggt tgaacgtgtc gaacccctgg
     5281 cgggtgttct ctctccaccc cgctgcgttg gctagcattc cttgacccat gagaaaactg
     5341 agcagtccag tgaatcgctc ttcgtggacg aggcgcgtcc ggtacggttt gccaggctga
     5401 tctgcgtcaa tagattcaaa gctgaagcgg tgttcgccgg tgaaaattcc cggaattgag
     5461 cccacccagc tgaagagggc cggggtattg gctttgacaa tgggcgtgaa atgcgtcttg
     5521 ccgtagttga ctgtacagtt caatcggtcc ccggcttgga gatgcgtggg gggcttgtca
     5581 gtgacagaag agatgtgttg aataaagcca gatggagagt aagtgggtaa agctgcgaaa
     5641 tccaggaact gtttcgagga cgaggtcagt ttgctcgggc acatttgggg gtgccgggat
     5701 aggccgcacc ttgtctcgta ccaccccggg aggggctgcg atctccacgc tggttgtgat
     5761 ggtatacatg gaatattagc cacaagggat tcttgacata gttgagtcac tggcgatgac
     5821 gagcagtgat ccaggattcg gcatggcctt tatatggcga ctcgagcggg cgtacgggat
     5881 gccgcgtccg aaagcctcat cgttgcagct ccatgtgtgg ctaggatgcg attgttagtc
     5941 ttgcgagaaa gattgaccca gttcgtcaga ggtttacaat atacccagcc agatacagcc
     6001 agaacatatg tgacagtatg aatctgagat tctgtggcac ccaaattggt atgctttctg
     6061 ccaccattca tgcatatagt cttcatcgac agagtgaaga catgtccatc taacacctgc
     6121 cccgttttca gggaggcgac gacgaagcat tcgaagtatt ttgcaatata tccagacagc
     6181 ttgtacataa tgaaatcgat gttccagggc acacggtgga tttccgaccg gcggccaccc
     6241 tcccccctcc gtccgttcgg gatacgattt ccgggcggag agggggtttg tgccctcaat
     6301 cctccatccc agactcgcgc agttttcttt catttcggat tgacattccc ctttgccgtc
     6361 ctgactcaag agttcttcat ctataatgtc tctcggctcc atcaggggaa cagcggagga
     6421 cctcatgttc agaccatgcc cgccacatcc agaaatcaac gatcccttcg gaagcatgtt
     6481 accacggcct gcatcccctg tcgtgatggg aaagttaagg taactaactc cccaccccct
     6541 catctaacta tctgcgcgac tgatattctc tgcaacagtg tggtgggggg accccaactt
     6601 gtagaaactg cgccattcga ggcaagacct gtcgctaccg gcaaagcgat gacaaacgga
     6661 aagtccccgt gcgcccggcc gtggccgtgc tggcacgccg ggtggacagc cttgttcacc
     6721 atatccgaga gtgtggccta ccagttccac ccatcgatga ggaggaccat cgcatcctga
     6781 agaatgtttt ggatgccctg gagctgcgat gcgaggacgt ggttgcagat cccaacgaca
     6841 ccagcagccg accagggctg gctaatatcc tgcccaccac gcctgtgtcc gtcaacagca
     6901 gcgctcctcc cacccagccg aatgagactg acagcgtagg gccgtctcac cagccgtcag
     6961 tttgtctgga gcctcttgac ctctcgtttg acaaagaacg ggtggcgtgg aaagactcca
     7021 ctatttcgga agcgcccagg gaagaagaag aagaagtagg agacagtgat gacgaagtca
     7081 ccgaccagct ctcctgtcga ctgggacgat tgcaagtaac tcacgatggt caacttcgat
     7141 attttggctc cacctccaat ctaacgctcc tggatgcgct ggtggatgtc actccacccg
     7201 tcgccattcc ccgagatgca cccgagttgc tggagaatgc aaagctcaac caagaagtcg
     7261 acgaagcatt cgaaaagcac ctaattgatc tcttctttgc ctggcaggat cctagtctgc
     7321 atgttattga tgctgagagc ttctggcggt ctcgtgcgca gagccgtgag gagggcctcg
     7381 ccacgccgta ctattctcga gccttgtcgg acgccatgtg cgctctgggg gccgcctatg
     7441 aaccgaaata tcatcccgac tttgtcacct ttccccgatc actcgccgaa ttttttggcg
     7501 atcgggcgaa gcttttggtg gaactcgaat tggataaccc gtcgattgca accatccagg
     7561 cccttgtgat tctcagcaat catgaagcat cctgcactcg ggatacccgg ggatggcttt
     7621 acagtggtag gttatagccc tttcccgaca cggggacgaa ttgagactaa ataagtaagg
     7681 aatggccatg cgtctcacat tggacctggg gcttcatctc gagatgggtc cgtatgtgga
     7741 aaagggtatc attcctcatc aagatgccga ggtgcgccgc atggtcttct ggggtgtcta
     7801 tctcaacgaa cagtaagtat atcttgcctc ttgtcatggg ttgacctgct tacgaagcag
     7861 gttctgggga ttctatctgg gccgctccgc ccaatgtcgg atggatgctg tcaccgtgcg
     7921 gaagcccatg tctccgagcc cggttcctac ctccagctgg aagccatatc ccgatcagct
     7981 cgggaccagt ttcccgcaaa tccccttcaa ccctttgtgc caggaatggg tctcccttta
     8041 cgagatcatg ctcccgctta cggatgtctt gtaagatacc gcttctgatt aagaaatctc
     8101 cctagagcta atggttactt gccaagatat ggttgttcag agatctctac tcactccctg
     8161 caggagctgg cttcggtaac agttgagaag ctgcaacaat ggcatcttaa cctcccagta
     8221 gagctcaagg ctgatgaagg gactactttc cgatcaccgc tgccccatgt tcttaccctg
     8281 cagtgagtca ttctagaata attcaccccc ttcccttgtg aggactaaca aacataagta
     8341 tgcaatacta ccagttcatg attcattgcc ataaacccta catctcccga cgtcatatac
     8401 agccccagcc tcctcaaggc ccgggttcag gccatgctcg aagaatgtgc atcgaatctg
     8461 cagtggccat cgttcaactg ctggacctct atgagagatc ctacggattt gacaagtcaa
     8521 gtatacaaat ggtttcgttc gtattctccg ccgcactaat attgattttc aacactattc
     8581 ccgccaagac cacatctcaa gatcaacacc tggtgatcca cctcagtact tgctttaggg
     8641 cccttgaccg tatggccagc tgcttcgaga atgcccgacg caccagcgtc ttcctgggca
     8701 ctttgcgcca acaatggcaa gtgcgccgac agaaacgccg agctcgcgca ggcagagtaa
     8761 actttgctta tagccgtaag ctggaccttt cggaatcagc ggggtggaac cgggatggta
     8821 gtgaagcgta ctcaagtgtg cagtgtcagc ctgcggtaac agagagttcc gtcacgggtc
     8881 tggacactga gcttagtgat ctcgtgccat attactctgc cattgccgac gcccccgcgt
     8941 ccacagttga tttcatggga cccaatctct gcaacatcct actcagtgaa gggatccctc
     9001 gcgcattcgt ataagtgggg atatattgga tgacgtttgc cctcttttgg tatatgcccg
     9061 ccaatgtatc taatcgtgta gcttaatggg tggatgctct atgagggttt ccagcaacat
     9121 ccaactgcga attccaagtc tccttgccga gtgggtcagg catgcagaca agcgtaatgt
     9181 acgtcgaaat agcttctaat gcctttccca ctcggtaaat ttttccgata aaaacactac
     9241 ctgccttcca atgatggggc ggattgttga cgccgggaga aaggggtaaa ggtaaaggct
     9301 acaatgttgt tcatttcagg atcctctgta atgcggtaga aaacatgtaa caagagccac
     9361 cttcaagtga aagtagatct gcatgctact agtgcaaggt attcgatgat gataaacttt
     9421 cggactctca accctggcaa aacgacaaca gcaggtcggc tcttccagat ttgacttctc
     9481 acatttactg tgaagaaagt tcgactactc aatgggacct ggcgcatgcg ctcgctgctg
     9541 ctatatcgag gcacatgcat atcaacacat gcaggaggcg aaagggtcag actcccgctc
     9601 cctgcaaaag actggatttg gatagtacat cagaaggggt gttgtgccag gatcgagcaa
     9661 gatgacgcaa agaaacgtta aacttgcatt tttcttggat tactgcagtg gctttgtccc
     9721 tcagcggtag cccgcgggca cttgtcatcc cacacatccc aggttctccc gcgtcttttc
     9781 tgcttggccg gtcgcaaaaa cccacaacct atgtcgtatt ggtcaatgac atttttaact
     9841 tctattcctg tactcccgat tgatatatct taatataagt aatgctgagc tgttcaagac
     9901 atggaacgaa aatccacggc tgatccgacg gtttcatgag ataaaaccca ggcattactg
     9961 tatcttcatc aacaaccgct acatattatc atctgcgaaa atggaaaaca aactttcacc
    10021 gcaggatgtc attcttcaga agttatatgg tcatacatgc gttatacctg atctacggtc
    10081 gtttatgaag agtgaatcgg ggggcataaa taaacaccga accttgttac cgctatgcgt
    10141 ttatgactat atagataggt atgtgtctag cgtcccccac agataacctg accccccagt
    10201 caagctgatg ccagtgagtc cctcagcctc ttaccagaag atccagccaa ggcgcaaaaa
    10261 gtgaaaggtg ccgatttccc actactagcc tgcctttggt ggccccatgc atcattcaga
    10321 aagctgcgtg tgttggcgtt tctagttgta tggttgattg tctgggacga tgaactggac
    10381 ggtgcctccc agtttacggc gtacgacctg aatatgggtc agcaatttcg ggatgaaaca
    10441 cgtcgttttg tcaaagctag tctgggactg gagtcagaag atcccaacaa cgttaccaaa
    10501 aatgctatca ttcgagggtt tagtccgata gcagattcta ttcgagagga atatgatgaa
    10561 ggtaggtgag cgtatttgga taaacaagat atacgtacgg ggatgctaac gctgcataga
    10621 acataggctt acgctgacag aagagatcat tttcgttatc cacatgtcca aggtggaaca
    10681 ggaaaatcgc cttgggatgg acataccttc aaccgatcaa tatcttgcat atcggcttgg
    10741 aacaaatctg atgggcgtga tctgcgctgc aacagagtaa gccactatta ctgatatgtg
    10801 gctaatgaga agttaatata tgaatctgaa aggctctcca tggattggcg aattccccgt
    10861 tcgataacgc gtagcccatg ggtgaaggac gtttggcacc aaacgaacct cataatcgct
    10921 ctgtatgtac actcccaata cggctctgat gcctcctgct gatcagtcaa tagtaccaat
    10981 gatatcttgt cgctcaagaa ggaaattgtc agccttgagt ttactcgtat agagaaagat
    11041 agactgacct agacttttat taggataagg gagaagtata cagcttcata cctgttcttc
    11101 tcaaccaaaa cagaacaccg caaaatgcag tcgacctttc gatccagata cttcaggact
    11161 ccattgcaga tttggaccgc atcaaatctg atattgtggc aagtagtgac caaactcatt
    11221 caaagttttt ggtcgagtct tgccgccggt attgcacggg atttctcgaa tggaggtttg
    11281 tgaaagcttg cccagataat cgaaccaaat ataactatat gatacagcct tattacccca
    11341 agatacaagc ttgccaccgt gcccagagat cagacagggg ccatggtatt attgttttga
    11401 gaccactgat atgttggaaa attatacaat gcagaagttc cacgcacttc atgaaaatat
    11461 aggaatacct tctacacacg ggaaactgac agtagaaggc aaggcacata taagcaccag
    11521 ctatcgtagt taattaaatt tcttcggcat ctagaatctg tatttttcat taatatcacc
    11581 ttggtctttc aagatttagg cgtcacacga ttgaattaca acaactcgct tgatgtagag
    11641 cttatacttc tctcagctga tggccactgt gattactgca gtttattttg gacattgaca
    11701 gtctacagtg actttcaata tggcaatttc tgcttcctca ggccttggag acattggctt
    11761 tctaaactct attcaacgtc gcaattttta taagaaagac ttgaagtaca tgcatctttg
    11821 taaaggttga ccgaagaaag cgatgaacat atagcaggaa tttcaagcgc acaattcgaa
    11881 agaacaagca aggatttcag tagtgagtgg ttttggatgt gataggagta gaagttgttc
    11941 cttgcgcatt agccctgacc taccaaaacc agtgacttgc agatcggcaa ggcgttcaac
    12001 ccaagaaagt aatggcccgc actaggtaac ttgcagcgcg ctcttgcggg tggactacct
    12061 gaaatgacaa ttgcctggaa aagatcgtca aaatgccaag aggtcgaacc ttaccatgaa
    12121 tgatgtgaat attgactgct tgtcaggccc ttaccggagg tgatattcaa agttacgtat
    12181 acattgacta gattaggctc gatattcata ttcagacttt cagctaatac atccgcacca
    12241 ctcaccttca tcaatattgc ctcgccgcat gtaagaggcc gataatagta aaccgaccca
    12301 tcctatgacc gagccaatcc ttattagtat tccaagagcc acgaacccgc tcaagcctcg
    12361 aaagcatgtt agttggttga aggagtatgt taaagttcgt caacatcgta gatggcataa
    12421 tccatctgat atccgatgtg gttagaactc aaaatatgta gccgatcaat tgcatcacac
    12481 actccaaggg gcttcaggca tggaaggatt ctcgtgaggt attatgaatg acatcacacc
    12541 actggccttc cgcagttcta acaacaaacc tctcataata aagggcgtca ttgcttcaac
    12601 tggaaggcga tgtgagtcca tcatttgcga gctgtcactc ttgtgtggag gtcaaatcac
    12661 actttaagaa agaggagtgg ccatataatc gttttttctc atatcaattc agttcaaggt
    12721 aatttaacta cggtgcaagt cacttgcctc aactgaactg tatgagagga gattagaaag
    12781 cacacagact ttcgtggaag tcaccaggaa actctacagg taactattac ttcgtcaaag
    12841 acgactcgat agtccaaata tgcctacaaa ggacttgaaa gtggtcatag ttggaggttc
    12901 catcgcgggt ctacttctcg ctaatgccct tgctcgacaa ggtattgatt tcattgtcct
    12961 ggaaggtaga tcggaagttg caccatgcga tggtgcaggg ctatgcattc tatccagcgg
    13021 tgcacgtatt ctggatcagt tgggaatatt tgaggatatc caagcttatg ggggaccgat
    13081 ttctgttcag cgcatctggc gagatgatgg acagctgctg gggcacaccg aaactttggc
    13141 cttaatacca gtgcggtacg tcgaaagcat agtcccctac ttcacacgtg gggatcctca
    13201 tttgtttgct gttatgataa ttacgacaat accatcgcta agaccaagtc agacagggct
    13261 atcctgtcat tttcgttgaa agacaacgag ttcttcaagt tctctttgag catctgccgg
    13321 acacgaaacg cgtgcttctc ggaaagaaag tcatagacat tactgcatca gacgaccaag
    13381 ctatagtgaa atgcttggat ggcactaatt acgaagcgga cataatagtt ggagcagatg
    13441 gaatacacag cattacacgc agaaagatga taagggatat tatcagcaac tgcccacaat
    13501 cgcacattag tcatgggcag ctaagacgag gtattccatc aggcacctat acattgccca
    13561 atgctaataa gtaataaagt gttcaccgct caatatgcag ccgtctttgg cctctctagg
    13621 ccaactcctg ggatgaagat cgggcattgc aacagaacgt tcgccgatgg gttctctttc
    13681 ttcaatgcgg taggcaggaa agggcagatc ttttggttcc tatatcgtga tatgggaaag
    13741 gtatattctg aaaaggatat acctcgcttc gatcagaaca aaatcgagga agacattgct
    13801 cccttcctca acaagtacgt tgcagagggg gtgagattcc aggatatctt caaaaacaga
    13861 gtccaatgtg cgcatgtgcc tattgaagag ggtttcttaa cccagtgggc gtggggaagg
    13921 tatgcatgca ttggggattc agtacacaag gtacaatgac gattctacta ctgcgttccg
    13981 ctctaatctc caaacacaga ctacaccgaa cttgggccaa ggcggaaacg gggcgataga
    14041 gagcgcggct tctcttgcaa ataccatcgt ttccattgct cacagcgtca aacttgaaag
    14101 cctgtcagta cctgagattt cggcctcttt ggatgagtgg gccagatcta gacagcggcg
    14161 gatgaagctc atttgcgatt tgggtaacag tttcacgaga ctcgaagcat ttcatacgct
    14221 taaagataag gctttgggtc tctaccttgg taaataccaa gtggacgcga ttgctgacat
    14281 tctgtgcgat acgactgtgg gcgcagagaa gttatcattt ctcccacttc ccgagaaatc
    14341 ggcacatgtg acaatgcctt ttgacccaga aaaaggtatc catgctgcac caagagtaag
    14401 gtcgttaatg ctgcgtgcac tactcccctt tatcctgatc tttgccgtcc agcccactgt
    14461 gcggggtttt atgaacagtc gtatccttaa gcccgtgtct atctcatacg agcatgaggc
    14521 agaagcattc gattttctcg gttacgatat caattatcag agtatccagg ctctagcagc
    14581 aatgtctcga attgcagatc tcggggcgat cctaggcatt tgggccttgg aaagctgcag
    14641 aacaggaaac gttgccactt taatgtcgtt gtaagtttcc tgtagatacc cagtaaattc
    14701 ctgggctttc taactgtttc atagtccatt aactttctcc tggataatgg gtatttttga
    14761 aggaactaat attgtagttc cattatactt tttattgtac gccatacagt caccggcagc
    14821 aaaatttact gcaccagatc gtcgcagcac acaaggatct tacacgagat ccttgatccc
    14881 gtgtctcata ttatgctact acattccggg attttggatg gtgtataacg actctggggt
    14941 gcacagtcgc cttggatgga aattcgtcct tttgtctact ttattccgat tgtcccacgt
    15001 ccaggtagcc tcccttctga gaagaacaac agtgagagag cttatagaaa cgccagatgc
    15061 agacatgcct tacatgagga tagcttacta cacatgcggt ttactatctg gggctatgtc
    15121 aattatgtgg agggctctag catctcggtc gctttatgcg agatcactcc cgatatcaca
    15181 ggtcctgtac caaacaactt cccccataca catcgaccat catggaatga cggggtgtgt
    15241 gtgtggtctc gcgtggcttt tatttgagta taaggacatg aaactcgcga aagccattga
    15301 tctgtcctgg tcatgtctca ttctattggg cacactcata actctggttt tcgggctggc
    15361 agcagctttg atgctaggat ggggtctgag agaagagtac ctagcaaagt atgccattca
    15421 gcactaaaag atagaaaact gtctttgcaa acataatgaa caaccggaat ggtatgcttc
    15481 ggttgccaca tttgttcagt ctcaagatat gctgaatacg taatagcgat ggccagtgat
    15541 gttcccgtaa cttcatgtgc ggtcaagaca gtgaataaaa tgatgccttc ttcctaatag
    15601 tcactctttg tgtgcttagt atatattacc tagatgtcag acctgaggtt ctatttctac
    15661 ttaatatcta gagtagattg tccaagcgta acatcacgag ggttggtcgt ttaaagactg
    15721 cctgagatgg atacgctttt tggttcaggg aagcgccgat gcgtcgacca acgctgtaga
    15781 actatggact cgccgccaac gcactctact tgcttgagag gctcgaaatt ggcttgaata
    15841 gtgaaggtta gagtaacgga tacctggggt tctcgatcac gacttcagta acatgacaat
    15901 atcacggatc atatgcacgt agaccaggac gggactgaaa ggcagaaaga gaagcagaca
    15961 aaggggatgc cccacgtttg ttggttctta ggaaggggct tcgtgagccg atgcagcgtg
    16021 ctgatgtgcc gaatgtcccc tttcatggaa tatcaaaagc aagggttcga tttgctggta
    16081 acaccccttt tcggtgcctt gagttatgcg ctgagtttag aagcctacat ctttctgtga
    16141 attgtctact tgtatttgat gtactcgatt cgtaagatgc gctacttcgt aatatttcta
    16201 aaatggatca aaaacatgaa aaagtctgca actcacctga ccgtctcctt acatccttta
    16261 gtctcacgct agattatgcc tacagccttc ccgttactac gagctgcatg atgtgtaata
    16321 ctgcgatatg tactcttgtg agttagtggc ttgccaattg cgagatatat aattaaaggt
    16381 attctaagta tgcgaggtct cacataggac cccatgatgc ggttgtttgt ccctcacaac
    16441 taccatgtcc cgttcatttt ctgttccagc tatgcgtcgt ccccttgttg agtgtgaaaa
    16501 agcactaaac agagtatgcc agaggtatca actttttact ccaaccaact ggcaattgtt
    16561 atctgttgcg agcggtttcc ttttcgtgac aatcctcttt ctcgcactta tagcatgcgg
    16621 cttcatacca cctcttcccc catcatgggg tgccgacaag gtatacagtc actatcacgg
    16681 acacagaaag ggcattcagg cgggagccgc attgatactt atctcctccg ggttatgtct
    16741 cccttatggg gcagtgatat cgaagcagct tcgaatgata cgagatgtag acccaattct
    16801 gtgtgacttg tctctcgtgg cttgtggggt agggagtgtc tccttcatga tgtcgtcgac
    16861 attccttgga ctggcgacat ttcgggatta cggcccagaa ttgactttac ttctcagtga
    16921 ccttttttgg ttcaccatcg tcatgcagtg gccgccattc tggatacaat gctggaccat
    16981 aacgtgggca attctctcgg atagaagttc aaaccctgcc tttccaaggt ccttggccat
    17041 cctcaacttt attgcacctt tggcattgtc ctcagctaca gccatccacc tctatcatcg
    17101 tgggccgtat gcatggaacg gcgctctaag cttttggttt gcctttgttc tcttcttcgc
    17161 ccagatcgag ctggatttaa tcaccatcgg tcggaatgtc ctcgaacatc gaaggctgga
    17221 attcaatgag cggacaattt gaattatcac taatgtgtct gtttttgatt tcgaattttg
    17281 atgcggtgcc gcttccacaa gcaagtgcga tcataagatg agatgtgctt gcctgacctt
    17341 ttgtatttcc ctgttaatgt gtgacacagc ctaaaagcca tgatgtttgt taactaatga
    17401 tgattccgtc tgctgtaaag ctagtttgga atgctggcca atgcgtggtt ctgtatgtag
    17461 taaacattgg cacctctagc gtagaccggt gttgcatatt aacacttaag cggccagcac
    17521 agtaggtgca acttgggcta atattgcccg cgcactggca gcggtaacgg ctctactgca
    17581 ctttaagtac acacttggtg gattttttat aaatgtgctc acaatattat cttgcttgca
    17641 cgccagacgg ctgtatatag tcaaattaca caaaagcttt agtgtatagt cacatttgcg
    17701 gtctcgttgc ctgctttaat caagtgtgag acgcgaggaa gaacgcggaa aaccaggaga
    17761 cagctccgcg gaagggctcc tattatataa gaggtaggat tcccgagcat tggcattctt
    17821 cgactggtta atggtcgtca aaccccgatt gaagtttttg atgcaaattg cagtgcaaag
    17881 aaccgttccg gcagtcagga ccaaggtcaa agatgcaaag aacagcatca tactcttccc
    17941 agctgtgttt gccgaagaga gaatgacaat ccggctaata agatacgcga ttaaggcaag
    18001 gtagcacatc tgtcatatag tgattagaag gcgatggagt aactcgatgg gaccatatta
    18061 gaggcagaga agctcacaat gatagcaacc gcaccaatgg ttcgttcgcg ctggacaaac
    18121 cagacaccaa ggaatatcgc aatgatggca gcgggaatga taaccattgt aagagtatat
    18181 tctggttcct taaaatgcac atataccaag tcgtattgta tgatgaaacc aatcagaaaa
    18241 tagaagtcga gctttattag tacgaggaaa atctgagctc acctatcgtt agcaggacct
    18301 ccaggatact ttatggggag tggaacacga aagggtcaat gttacctcat aagccaggta
    18361 acgcattcga gtatccaagc tgccgtgaac agacttgtag atggcccatg aataatgcct
    18421 atggattaca tatgcaattg ggcatagaat cagagcggag aaccctgtaa agatacatac
    18481 aaggatctct gctggctgaa cccgaggcca gacattgcgt gtagtatcca ccaaagtcgg
    18541 atacccaaat cgtgtcttga acagtctcgc agtggtatct ctcatcacga taaattgcat
    18601 cacagaatag ccgaaactgc acgcattaca gatgcagact gcaaacagaa gaatgttatt
    18661 cttgtgatgc attgcatcca aggatagaat gaactcgaac aagcacgcga aaatcaaaat
    18721 gcctaggtta atcggtatca agtaggacac cggcacttga ttgattgttg gggtaaccca
    18781 ttgctgccat tcaataagta tatagctgtt tttccttggt taggtgtgct cggatctgca
    18841 gaagtggaag ggcgtacacc tcggagatga tggttaaagc tgcctgtgtc agcaacacgc
    18901 cgcatagcca ccattcatac ttggtcgttg gcctatacat gcttccgcat gaatacgatg
    18961 ggcgagctgt gttgactgtt tccattaatt tcctgccaat agatagatct tgccgccttt
    19021 ttttactttt ttttcccttt tcttccacgg cttccacgtg ataacggtgg gcgcaagcca
    19081 caacaggcgg cttgaaaatt ctccagatga tggccaggtt tgtatgcgtt tgattgggtc
    19141 gtaggcagca gttacggggc cgatatgggt tgagtatcgc ctattggttc atagtgagac
    19201 atgtccgcgc acgcttacac aagtagttag accttgccaa ggcactaaag gggatccgaa
    19261 ccttgggcca tctttttaat ggttggagtc agaaactatc gaacctgtga ttttcagcta
    19321 ttaaccgcta gatagatcac ccatccccgg aaagagcggc tgcgcaacgg ggaatagtct
    19381 aatagtttgt ccctggtctt cggcaacgtt accttatctg ttacgtgcca aattcggttt
    19441 cacaagtgcc tttgctgcac gaccggattc tcctacttcc acagctagaa aaaaacaggg
    19501 ttattgtcgg ggttctgtat actttcaatt gtccaggtag cttagcatca gatgacttca
    19561 tgcatctttc ttacacctct actaacccat ccaccggttt taaaaatgcg aacagtgttc
    19621 tttgtgtccg cttctcaagg cttaatgaac aaaggggcca ggaacatcgt aaggaaggcc
    19681 aattaaggtt ccatattggg gactccaccc ccttcagact tggcatattc agtatacaga
    19741 gtagattcga ttgtgggcca cagatttgtt gaactaccag aacggtattg cttagacatg
    19801 gttattacta tgttactctt tctcgaccct gtgagaaatt tttaaacaga gagtcattat
    19861 ccagaaaatg caggtgcatg atatttgcgg cagacactct ttaaaacttg ctaccccaag
    19921 cattggagag ctgaatgata tctatcccga ttcgcttcca ggcgtacgtg aagatatgat
    19981 tttgtttgga tacactgtgc aatactatat ggacacaagg aacgggactt aacatttaaa
    20041 gggaaactgt ttaggctgcg accatagctc agatcggcat caaagacaac cgggtgagaa
    20101 aagccaatgt ttatgtcatg ccttctggtc ggggaatttt ctcagcatat cacccaatcg
    20161 atcaataggc gcagacatga gaccgacaac agtttcgtac ggtggctgat caggggccgc
    20221 tggatggctc cgagtcggga taaaattctt ggtgcgaccg aaagaacgcg ccatgctttc
    20281 ggaggcggag tcaccgagag cgctttcaag agccggtaga tcttggcttt cttcctcttt
    20341 gatgtgctgc tccaaattgg cccacaggct tttgagggtg gggatgaact cggtatcatc
    20401 cggctgaagg ccttggaagg tatacagaag ctccttaatc tgcagtgcca aattgttcag
    20461 tttgtttcaa ataacaacgc aacaaagcga acgacagcat accacttggt gttcctccct
    20521 gtcatgctgc gccatggcct tcccgttgtt cagctttagc tccatttcgg gatacacgac
    20581 cagctcctcg ccgatggagt ggcgagccag ctcccaggtg aattggttct gccatctgac
    20641 cctgtcatca ttcgtttgag cacttaaaat ctgatgataa gcacccctca gttcctgatg
    20701 gtcgttcttg atgagttcag acacgcgaat cgcggctggg gcagtgatcc ggaaatcacg
    20761 cttcggtgtc cgaactgctt tggagaagag ggaggcctct ggtcctctaa atgatcttct
    20821 cgcacacaat gcaaacgaca ttctcgcgct gtctgatcgg ctcataggat ggcttgtagg
    20881 aatcagctca aacggggaag cattacggtg tgtgcacagt cacatcgttc ttgagttcgc
    20941 ggggtacagt gcagaaccgg tttataatgc ctgagttccg cattctggac cagctcgaaa
    21001 gtatgacaca agcggacagc aaatattgat cgctggccac agtgcagcca gccaacaatg
    21061 gttcagcaat taatcatggt ttgtttgcgc ctcaaaagga gagcctggta gtggctggca
    21121 tgatagaaca atgacatagt gcagacgtcc cagttgcagc ggatcgtggt tctgcctgtt
    21181 ccgccaatgg tagtcgcaag ggatcattcc catgcgaaaa gaacactgaa taacaggctt
    21241 gttaaccgct agattccctg ggagatactt gacggccccg ttgacgcatg cagcctggcc
    21301 acagccaccc agtcgatttg ctcatcacga cgacagcctt cccagagtct aatcggggtg
    21361 gaagtgcagg gaaccgtaac tctattttgc gtgaggtaac
//
