LOCUS       KZ851917.1             22559 bp    DNA     linear   PLN 20-AUG-2019
DEFINITION  Aspergillus niger.
ACCESSION   KZ851917
VERSION     KZ851917.1
KEYWORDS    .
SOURCE      Aspergillus niger
  ORGANISM  Aspergillus niger
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Eurotiomycetes; Eurotiomycetidae; Eurotiales; Aspergillaceae;
            Aspergillus.
COMMENT     'Annotated using funannotate v1.6.0-df4262f'.
            ##antiSMASH-Data-START##
            Version      :: 5.0.0
            Run date     :: 2020-11-02 07:38:58
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 314275
            Orig. end    :: 336834
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..22559
                     /aStool="rule-based-clusters"
                     /contig_edge="False"
                     /core_location="join{[<324275:326292](+),
                     [326376:>326834](+)}"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      join(<10001..12017,12102..>12559)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     cand_cluster    1..22559
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..22559
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="2"
                     /rules="(Terpene_synth or Terpene_synth_C or phytoene_synt
                     or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps
                     or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /tool="antismash"
     mRNA            complement(<1117..>2901)
                     /locus_tag="M747DRAFT_315531"
                     /product="hypothetical protein"
     gene            complement(<1117..>2901)
                     /locus_tag="M747DRAFT_315531"
     CDS             complement(<1117..>2901)
                     /codon_start=1
                     /db_xref="InterPro:IPR006101"
                     /db_xref="InterPro:IPR006102"
                     /db_xref="InterPro:IPR006103"
                     /db_xref="InterPro:IPR006104"
                     /db_xref="InterPro:IPR008979"
                     /db_xref="InterPro:IPR013783"
                     /db_xref="InterPro:IPR017853"
                     /db_xref="InterPro:IPR023230"
                     /db_xref="InterPro:IPR023232"
                     /db_xref="InterPro:IPR036156"
                     /db_xref="PFAM:PF00703"
                     /db_xref="PFAM:PF02836"
                     /db_xref="PFAM:PF02837"
                     /locus_tag="M747DRAFT_315531"
                     /note="CAZy:GH2; GO_function: GO:0004553 - hydrolase
                     activity, hydrolyzing O-glycosyl compounds [Evidence IEA];
                     GO_process: GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /product="hypothetical protein"
                     /protein_id="ncbi_M747DRAFT_315531-T1"
                     /transl_table=1
                     /translation="MLKPQQTPFRDIVSLDGIWKFALGSSDNETATPWTAPLATDLECP
                     VPASYNDIFVDRQIHDHVGWVYYQRQAIVPRGWSQQQYLVRVDAATHKGRIYINDHLVA
                     EHVGGYTPFEADITSLVSAGDSFRLTIAVNNVLTHETIPPGRIEVLEYTGKKTQVYQHD
                     FFNYAGLARSVSLYSVPKQHIQDIKVVTDVNGATGQIKYLVTVTNATTERIKIDVVDED
                     GRTVAEASGTHGNVTIDSVRLWQPGDAYLYQFRVSIVGLDDSILDTYSVATGVRTVKVS
                     GNKFLINDKPFYFTGFGKHEDSNVRGKGYDAAYMVHDFQLMNWMGANSFRTSHYPYAEE
                     VMEFADRHGIVVIDETPAVGLAYSIGAGVSSEDSPQTFTPEGINNNTREAHKQAIRELI
                     ARDKNHASVVMWSIANEPASQEAGAREYFTPLVDLAHELDSDRPICFANYGDATYEVDR
                     ISDMFDVLCLNRYFGWYSQTGEIEEAEAALETELLGWEGKYDKPIVMTEYGADTLAGLH
                     SVLGLPWSEEFQVELLDMYHRVFDRVESVVGEHVWNFADFQAVVGVGRVDGNKKGVFTR
                     DRKPKAAVQTLRSRWSQL"
     mRNA            complement(<6522..>8177)
                     /locus_tag="M747DRAFT_306067"
                     /product="efflux pump antibiotic resistance protein"
     gene            complement(<6522..>8177)
                     /locus_tag="M747DRAFT_306067"
     CDS             complement(<6522..>8177)
                     /codon_start=1
                     /db_xref="InterPro:IPR011701"
                     /db_xref="InterPro:IPR020846"
                     /db_xref="InterPro:IPR036259"
                     /db_xref="PFAM:PF07690"
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 313; E-value:
                     4.4e-95)"
                     /gene_kind="transport"
                     /locus_tag="M747DRAFT_306067"
                     /note="GO_component: GO:0005887 - integral component of
                     plasma membrane [Evidence IEA]; GO_process: GO:0055085 -
                     transmembrane transport [Evidence IEA]"
                     /product="efflux pump antibiotic resistance protein"
                     /protein_id="ncbi_M747DRAFT_306067-T1"
                     /transl_table=1
                     /translation="MPSDPSDLTALKPPTTATSQVDSESPLHETKVVSHRDTDRDSDAH
                     EKYIDGVLLHVIVLCLAVAMFLVSLDTTIISTAIPQITDEFNSTADVGWYGAAFLLGSA
                     VTQAPWGKLYGLFDIKWTYLLSLLMFELGSLLCAISHNSPTFIIGRAIAGIGGSGIGSG
                     IYTVIGVCVPPKKRPILVGVTGLAFLLASFAGPVIGGEFTSNLTWRWCFWINVPVGGAT
                     FAVLLLLFRPPFRRANVGVSRKEIILQLDIPGVITLRGALLCFLLSLEWGVSKSWHDRD
                     VIGCLVGFPILTGLFITNEFFWDDRAMIPRRLLLKKEVVVNLIVIFLLAGAFFMLLYYM
                     PIYFQTVKGNSAQDSGIRTLPLIVSAGVMAVFGAIGFGISGYPTPFLLFGAMLISVGAG
                     LLYTLDLVTLSSHWIPYQILAGLGIGAALQVPIIMNQATVDESDMSTMTSITLFFKCLG
                     ASVFMQTGQTIFLEKVKRNLDMMTVADVNPNQILTGGLVRVQAIDSASSIALRTAYLGG
                     LKDVFLLVAALSGLAALLASLMGRYKMDTARLRL"
     mRNA            join(<10001..12017,12102..>12559)
                     /locus_tag="M747DRAFT_352036"
                     /product="squalene-hopene-cyclase"
     gene            <10001..>12559
                     /locus_tag="M747DRAFT_352036"
     CDS             join(<10001..12017,12102..>12559)
                     /codon_start=1
                     /db_xref="InterPro:IPR006400"
                     /db_xref="InterPro:IPR008930"
                     /db_xref="InterPro:IPR011004"
                     /db_xref="InterPro:IPR018333"
                     /db_xref="InterPro:IPR032696"
                     /db_xref="InterPro:IPR032697"
                     /db_xref="PFAM:PF00432"
                     /db_xref="PFAM:PF13243"
                     /db_xref="PFAM:PF13249"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: terpene_cyclase"
                     /gene_kind="biosynthetic"
                     /locus_tag="M747DRAFT_352036"
                     /note="GO_component: GO:0005811 - lipid droplet [Evidence
                     IEA]; GO_function: GO:0016866 - intramolecular transferase
                     activity [Evidence IEA]; GO_function: GO:0000250 -
                     lanosterol synthase activity [Evidence IEA]; GO_function:
                     GO:0042300 - beta-amyrin synthase activity [Evidence IEA];
                     GO_process: GO:0019746 - hopanoid biosynthetic process
                     [Evidence IEA]; GO_process: GO:0016104 - triterpenoid
                     biosynthetic process [Evidence IEA]"
                     /product="squalene-hopene-cyclase"
                     /protein_id="ncbi_M747DRAFT_352036-T1"
                     /sec_met_domain="terpene_cyclase (E-value: 6.2e-24,
                     bitscore: 78.7, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MASETSISLHTLACDATKLAGTYALRQVREDGHWYGEMKSNATIT
                     AEYVFLAQALGFSIEEDRDDLIKYFLSEQNTDGSWSLAYDFPGDVSVTAEAYFALCLLG
                     LDRSHPAMASAREFTLSKGGIAKVRVFTRMFFACFGLFPWSAVPELPAELILLPAAAPM
                     SIYQLASWARATVVPMLVIRHHRPIYALPNGRSSSNEYLDELWVDPTDKMVPYSPSLWS
                     LWNDDLTAFGFTLADNILKALGGLRWFPSRKIALRHCVAWILERQEPEGDIGGIFPPLH
                     AALFALALEGYGLESSPVRRGIDALQNTYAWRDSTGLRIQGCISPILDTILMTIGLIDS
                     SLPAESPLVARSSRYLKAHQQLGNEGDWRVYNGNVPSGGFNFEYFNSWYPDIDDTAAAI
                     LAMVKQDPNLLDLGPILSAVQWILGLQNDDGGWAAFDRENNYLFLNKIPFSDMDSFCDP
                     STADVTGRVIECFGLLAKRGSVLSRNGKNPIPRFFIDDMSSATERAIDFLSTEQEADGS
                     WYGRWGSNYIYGTSAVLCGLVYHLEGWDDTYPVMEKRHKVDTHAALDWLKRHQNPDGGW
                     GERLESYYEPRLAGNGPSTASQTAWALMGLLAYLAPTDESITRGIQYLSRTQIKEGELA
                     GSWKEDHYTGTGFPNHFYLCYTLYSQYFPMMALGRYTRFDRPDARYVKFNIKLISLRST
                     VKTSQKLIPGFDLMDIGNDVVFGNRSCLGTVDRLGRKPIVIKDGAMLGDRSVGLPRVNI
                     GTRTMVGSGALLRRNGSYLDDRRSYCQRWQIQRTIDILIEESFGGRGIPVVNQRDSVPE
                     LVLSGDGGQDRV"
     mRNA            complement(12771..13355)
                     /locus_tag="M747DRAFT_296223"
                     /product="hypothetical protein"
     gene            complement(12771..13355)
                     /locus_tag="M747DRAFT_296223"
     CDS             complement(13002..13244)
                     /codon_start=1
                     /locus_tag="M747DRAFT_296223"
                     /note="SECRETED:SignalP(1-16); EggNog:ENOG41"
                     /product="hypothetical protein"
                     /protein_id="ncbi_M747DRAFT_296223-T1"
                     /transl_table=1
                     /translation="MRLLTYLLLTIYATSAVSTDLSVEEECGSLGVMKVDPADLPEGVT
                     LADVRKCADHPLGHLPHPGAATGGVLQRILPGWMF"
     mRNA            complement(join(<13772..13897,13962..14060,14110..14209,
                     14263..>14573))
                     /locus_tag="M747DRAFT_342075"
                     /product="FAS1 domain-containing protein"
     gene            complement(<13772..>14573)
                     /locus_tag="M747DRAFT_342075"
     CDS             complement(join(<13772..13897,13962..14060,14110..14209,
                     14263..>14573))
                     /codon_start=1
                     /db_xref="InterPro:IPR000782"
                     /db_xref="InterPro:IPR036378"
                     /db_xref="PFAM:PF02469"
                     /locus_tag="M747DRAFT_342075"
                     /note="SECRETED:SignalP(1-20); EggNog:ENOG41"
                     /product="FAS1 domain-containing protein"
                     /protein_id="ncbi_M747DRAFT_342075-T1"
                     /transl_table=1
                     /translation="MIFSFAPIIGLLSLISPVIATTDPLNYRNIPGYVTSSSLNVTTLV
                     DFIKSRSDLSILSEKIDELGGFAQAFDTDPNWKFTFFAPNNDAFELYTGAYFDSFEPTP
                     KGKWWLGNTIIHHYVPNSRLTSSSFNETLQRFQTATYLFVGSQMQDGAIVLNQVANVVE
                     SDIPVTSGVVHIIDRILDPSTQIFEPDLPRLSQTFIAGSCSNPELSYC"
     mRNA            join(<14946..15552,15617..>16239)
                     /locus_tag="M747DRAFT_352037"
                     /product="alpha-galactosidase/alpha-n-
                     acetylgalactosaminidase"
     gene            <14946..>16239
                     /locus_tag="M747DRAFT_352037"
     CDS             join(<14946..15552,15617..>16239)
                     /codon_start=1
                     /db_xref="InterPro:IPR002241"
                     /db_xref="InterPro:IPR013780"
                     /db_xref="InterPro:IPR013785"
                     /db_xref="InterPro:IPR017853"
                     /db_xref="InterPro:IPR041233"
                     /db_xref="PFAM:PF16499"
                     /db_xref="PFAM:PF17801"
                     /locus_tag="M747DRAFT_352037"
                     /note="GO_function: GO:0004553 - hydrolase activity,
                     hydrolyzing O-glycosyl compounds [Evidence IEA];
                     GO_function: GO:0003824 - catalytic activity [Evidence
                     IEA]; GO_process: GO:0005975 - carbohydrate metabolic
                     process [Evidence IEA]"
                     /product="alpha-galactosidase/alpha-n-
                     acetylgalactosaminidase"
                     /protein_id="ncbi_M747DRAFT_352037-T1"
                     /transl_table=1
                     /translation="MMKRKSQLSSFTLVTAAILPFAHFVMGGTSLAQKPQMGWNSWNAF
                     KATVNYTIVQEVISLFDTLGLKEAGYEYVLLDDGWASYNRTSDGYLQANATSFPQGIKA
                     LAQEVHGKGLKLGLYGDSGHYTCAWRPGSWGYEERDAQTFAGWGVDYLKYDNCGGFQSM
                     TEAPQIRFGAMKNALTLSGRDIFYSVCGWGYQFPWHWGGDIGHSYRMSGDITTSFTNET
                     ECQCKTAYCLNTGYAGCSVLTIINKMKEISQYQTPGHWLDMDMLEVGNANFTLNQQQTH
                     FAFWAALKSPLIIGADLSKLSNDSLAVLTNKAIISINQDALGEPVTYREAHSKEGLFQV
                     WAGKVEDGYVVLLLNEKSYPQTVSLSFASLGLGSPQKVTELWSGQTLQDLSKFNGTLGS
                     YQTLVFKVKA"
     CDS             join(<16730..16802,16849..16900,17042..17097,17394..17551,
                     17618..18616,18678..19237,19295..20088,20189..20232)
                     /codon_start=1
                     /db_xref="InterPro:IPR001138"
                     /db_xref="InterPro:IPR007219"
                     /db_xref="InterPro:IPR036864"
                     /db_xref="PFAM:PF00172"
                     /db_xref="PFAM:PF04082"
                     /locus_tag="M747DRAFT_323578"
                     /note="EggNog:ENOG41; GO_component: GO:0005634 - nucleus
                     [Evidence IEA]; GO_function: GO:0000981 - DNA-binding
                     transcription factor activity, RNA polymerase II-specific
                     [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding
                     [Evidence IEA]; GO_function: GO:0003677 - DNA binding
                     [Evidence IEA]; GO_process: GO:0006355 - regulation of
                     transcription, DNA-templated [Evidence IEA]; GO_process:
                     GO:0006351 - transcription, DNA-templated [Evidence IEA]"
                     /product="hypothetical protein"
                     /protein_id="ncbi_M747DRAFT_323578-T1"
                     /transl_table=1
                     /translation="MSLQSRLIVATVHSTTLVSREWHVVDAKFWFLLLVSDRWTDWFLM
                     THSLTRRESLVLLRILPGHYLFNYVDPLPIRLSIKHIEPLAKSFWENLRRRTLAGNYPA
                     RRQEADWRSIAGKTIPPWGRRSLCMPDSVCQTSPSWRQCSHGKFLNNLNSAYPMPPKSH
                     PATANANVGDLPETTNKGEEEIPACQFCRKKKAKCNRAQPCSQCMRSDVLCVYDDRRTK
                     PGLRAGAVDQLYRRVETLENMFLGQEMLWQQMWKALFPNTEPPRSLDKGTTAATTLTER
                     REQLKASLQEPPPLAAKRSLTVADADNSAPLDCVPLPAKRARVEDEVAPHAAVLEPEPF
                     LANSLPDIVLNELVDFYFVNIHPWIPILHVKRFRERMRSPEERGHINCILHAIISVCAR
                     FSQNGPNGDTLNLKEIAKKSRQEVILQSTETFSVENLQALVIVAFETINRGRGPSSWSI
                     IGSMAGTVEQLQLGVEEDDLYRVKRMGERLIRRMVCLTPSRSWSEAEERRRVFWAVFLM
                     DRFCSVSTGWKISLRNADVKRRLPCEGALWEKEQEVCTPYFGISDFKNTSMPNSHSTSM
                     DGSEEQAIGAFAYIIEATESLALVTNFYLHHVFLINDASKARLWLVKFKELDLRLIQWK
                     IHLPPKWREACVLNEHRVMDPNLTLAHITHNTAVILLHQGIAYPPSHWQYCPIKLPSAS
                     SADTCLEAASEIATIANKFLSFSPIFTNPQFSFCLFIAGRTLLAHARYNRVPPSPALNT
                     LIANLMEISQRWTRHHDASESQQEESLAFKFATRLIEAQQNRTSASRPSLDIRTTAYSD
                     ESKEEMYKDPMRTNQDDLPDYESLSRPLQLASFPSQESTSCTFDPFSLAFPPLPPAFQQ
                     DFSPTGLDPLSFYNMQLPSESMSSPLVRGRESVITAIHGE"
     mRNA            join(<16730..16802,16849..16900,17042..17097,17394..17551,
                     17618..18616,18678..19237,19295..20088,20189..20269)
                     /locus_tag="M747DRAFT_323578"
                     /product="hypothetical protein"
     gene            <16730..20269
                     /locus_tag="M747DRAFT_323578"
     mRNA            complement(join(<20394..21665,21730..>21873))
                     /locus_tag="M747DRAFT_352043"
                     /product="Six-hairpin glycosidase"
     gene            complement(<20394..>21873)
                     /locus_tag="M747DRAFT_352043"
     CDS             complement(join(<20394..21665,21730..>21873))
                     /codon_start=1
                     /db_xref="InterPro:IPR008928"
                     /db_xref="InterPro:IPR010905"
                     /db_xref="PFAM:PF07470"
                     /locus_tag="M747DRAFT_352043"
                     /note="CAZy:GH88; EggNog:ENOG41; GO_function: GO:0003824 -
                     catalytic activity [Evidence IEA]"
                     /product="Six-hairpin glycosidase"
                     /protein_id="ncbi_M747DRAFT_352043-T1"
                     /transl_table=1
                     /translation="MSIEAGPPTTINGTEVLPTKQWARVLEALFSESLLAKVWFVASKA
                     MGSTTPPTFYPEYTGEDKTTYIYRTLDFWTSGFFPGSLYLLLERSTLFRDRHLILQRQT
                     SESILHPHPLQHEHLCRWWTANLHQNALRKDTHDLGFMITPWAMKAWTLHRDPAAYNTL
                     ILAAHSLASRFNESTQCIRSWDQCITKRYAYRNSSQDFLFIIDNMLNLDLLFWAARETG
                     CRRLYDIARAHAITTQKHHIRDDYTTFHVVDLDLETGEVKKKFTNQGYSDDSCWARGQA
                     WGIMGFAQTFEWTREMRFLRTARALADVFLARLPDDGVPYWDFDAPVTDTSPRDTSAAM
                     IAACGMLLLYKAYKKMHDVEAANHYLRAAMKLVDCTVVGYLNPPMRFEAGPASEISVYA
                     DQCSTHHTETRNGAEVLRVVGDVAETILTGATINNYEFAPRRWSDHGLVYADYYFLLFG
                     NMLLEMDLVDPHI"
ORIGIN
        1 tacgacgaca gttaattata tggacttgcg tacactcagg gatgtcatca caacggcgac
       61 cctttgcttg ctctgatgat cagtgggaaa gtcatcctca gctgcttcgg taggggcatc
      121 ttttcccaga tcatgcttga aatggttgga taggttatgg tcctcttcta ggtgttggta
      181 cggtcgggga gagggatctt gctccgtatt gacagccatg taacagagac tggcgtgaag
      241 aattgaaaga agaaaggaat gtgagagctc tgaagaagag ggaaatgcaa taacaagtgg
      301 aaatgatgaa cgagcggatt cgactaggtg ctgtgcagaa gaataaaata tcggaaaaag
      361 ctgtggtgag atagtcttcc ccggacaata atcatcagag tccagaggac ttaatatgta
      421 ggcagcactc cttgacaccc tcatgggcag catgtgggga aatggatcga tcatcaattt
      481 acacaacgtc atggctattc taggctctga tcacgatgct gattactggt tggatctgtc
      541 tgtgtctaag gtggagaaga aggaacatca agaaaggggc agcagagagg gtttgcgctc
      601 ggcacagaca taagcgatgt ctggttttct ctactatgat actaaactat tctatatggc
      661 tactattcaa gttagttata attcaatata atatgttcat tgatacaagg ggtgtgcctc
      721 ataaaatcgc tgtatcagtc ctttactgga atgacagcat tagggggacg gacccagttg
      781 gaaaaggtcc tactggccga tgagccgctc ggcaaatcta caggaaaaaa ttcaacacac
      841 gtggcctgca attgtgggcc ccaattccct ttctctgact ggtaaattta aagccggaat
      901 tgccagtaga caatcgacac cggcccgtac cgtgagatgg gaagagagtt gcgaagaagc
      961 ttggcctcgt tactggataa gcgggccatc cacaggcctt ctagcagtcg cgcattcgaa
     1021 taccctaaaa gcaaagaccg gttttcccgc ccctaaagcc ccatgatatt ggctgcacat
     1081 gattaacctt tcaaataata ttcgtaactc cgcaccctac aattgactcc atcgacttct
     1141 cagagtctga actgcagcct ttggtttcct atccctggta aagaccccct tcttgttccc
     1201 gtccaccctg ccgaccccta cgaccgcctg aaagtccgca aagttccaaa cgtgctctcc
     1261 caccactgat tcgacacggt caaacactcg atggtacatg tcgagcagtt cgacctggaa
     1321 ctcctcgctc cacggaagcc caagcaccga atggaggcca gccaaggtat ccgccccgta
     1381 ttctgtcatg acgatgggtt tgtcgtattt gccctcccag cccaatagct ctgtttcgag
     1441 agccgcttcc gcctcctcaa tctcaccggt ttgcgaatac cacccgaaat agcggttgag
     1501 gcagaggacg tcaaacatat ccgagattcg atccacctca tatgtggcgt ctccgtaatt
     1561 tgcaaaacag atggggcgat ctgagtcaag ctcgtgggcc aggtcaacga gtggcgtgaa
     1621 atactcacgg gctcctgctt cttgtgatgc aggctcattt gcaatcgacc acatgacaac
     1681 actggcgtgg ttcttatccc gagcaatgag ctcccggatt gcttgcttgt gagcttcgcg
     1741 ggtgttattg ttgatccctt ccggggtaaa tgtctgtggg ctgtcttcgc tagaaactcc
     1801 agccccaatg gagtacgcca ggccaacggc gggcgtctcg tcaatgacaa cgattccgtg
     1861 ccggtccgca aattccatga cctcttcggc gtacggataa tgcgaggtgc ggaatgagtt
     1921 ggctcccatc caattcatca actggaaatc gtgcaccatg tacgctgcgt catagccttt
     1981 gccgcgcaca ttgctgtcct cgtgcttccc aaagccggtg aagtagaacg gcttgtcgtt
     2041 gatgaggaat ttgttaccgc tgactttgac tgtacgtacg cccgtcgcaa cactataagt
     2101 gtcaagtata ctgtcgtcca agcccacgat gctcacccga aattgataca gatatgcatc
     2161 tcccggctgc cacagcctga cagagtctat tgtaacatta ccatgagtac ctgaagcttc
     2221 ggccacagtt ctgccgtcct catcgaccac gtcgatcttg atgcgctctg tagtcgcgtt
     2281 ggtcaccgtg acgaggtatt ttatctgccc ggttgcgccg ttcacgtccg tgacgacttt
     2341 gatatcctgg atgtgctgct tcggaacaga atacagcgag acggagcgcg caagtcccgc
     2401 gtaattgaag aaatcatgct ggtagacttg cgtcttttta cctgtgtatt ccaatacttc
     2461 tatcctgcct ggcggaatag tctcgtgagt cagcacgtta ttgacagcga tagtcagtcg
     2521 gaagctgtca ccagcagaga caagactcgt gatatctgct tcaaaaggtg tgtagccgcc
     2581 cacatgctcg gcgactagat ggtcgtttat atagatacga cctttgtgtg tggcggcatc
     2641 aacccgcacg agatattgct gctgtgacca gcctctgggg acaatagctt ggcgctggta
     2701 gtaaacccat ccgacatggt catggatctg acgatcgaca aagatgtcgt tataagaggc
     2761 tggaacggga cactccagat cggtggctaa tggagctgtc cagggtgtcg ccgtctcatt
     2821 atcgctggaa ccgagagcaa acttccaaat cccgtcgagg gagactatat ctctaaaagg
     2881 tgtttgttgg ggcttcagca ttgctggtct ctgctggacc atttgacgtg ggtgaataag
     2941 tgaagggtta gaagatacat gctgaattag ggaaagtatt gacaatccta agaggacctt
     3001 catcatgaca gagtcaaggg agaaatcacc agttttctcg acatcgccag gagtagctac
     3061 atcggtgacg acgtgagctg gtaattggta ttaaatgata gaaggcggca attgactgcc
     3121 acaccgtcgg ctgttgatgc acttgtcatg ttattgcttg gcaaggacta attctttaat
     3181 tccaacagta atatctagtc aatgctccct tggcagcatt gccaagcaca tgtctctttt
     3241 attctttgca gatgtggtcc cgaaatggac ccgaagaggg tccaggatgc agccaagaac
     3301 caaagtgcgg agaaaataga gtttggtgcc ctccaacccg atggataccg tcatcatcaa
     3361 ttgccgacca aggatggact ttcttgaatg tctttggaga gcatgatgct tccagcgagg
     3421 cgatagatgg cgaccctaat tgatatcagt ccttatacgt accacctagc tgtgactgtg
     3481 tcagctaggt tgtattatat ttgaaagtac ttgacaataa tagtcatagg aattgcatta
     3541 ctcaccttcg caggaatact tgtctcttgt cattccattg aactttggac tctattatca
     3601 tggaaatgca attctcccat ttgcgtcggc gtagcgaggc taatatgaag aaaccttagc
     3661 ctctcaccaa gcattctaca tctgatcatt gaataaaaag cttcacctgc ggtattatag
     3721 cggtacaaat aatggctgca attttcattg actgacccgt ttcaattact tttgaatcaa
     3781 tcgatcaact attgggtcac aaggaacaag gacatggtat cagggggaat aagatgtggc
     3841 attccatgag aatggaattt ttgagactga gatcaaccag ttgggccttc acggccggat
     3901 gcgtgtagcg acgaagacgt aagcggatga gtcgaagatg gtcaaagtga atttgggtat
     3961 ttctggtgtt cacagatgaa cagcactagg aaaagtgatg agcagtggat gaaccggctg
     4021 aactacgttg accacggccg gtgaagttaa acattcatcc atgacatgct ataccaatgc
     4081 attgaatgca cattttttgt gcgctgatta acgcaacgca ctgggcgtca ctgtgtagaa
     4141 aaatattaca ttcacctttg gggtaaacta cgtaaacaga ttgggatatt taatcccacc
     4201 ttttaccccc ccgaaatgcc ttcccctttc tcctctgaac atgatcgttg aatcccccaa
     4261 tctgatgaga tgtacctggg tcttacctat tatacagatc cgggcacttc ccgtcaacgt
     4321 caggtactcc ggcatatata aaggtctccg tgttgtcgtt tggaatcttc ctaccactcg
     4381 gcaacatcga aactcaagtg ttgatctttt acatttttac aaacatgtca caatggcgac
     4441 acctcctccc acagatacaa cctcacttga caaaacagtc gggaaaagag aagagctcct
     4501 gagcgacaca gcaatgacaa ttctaactca acttagtgag acatcgaata tcttcttcca
     4561 gccatcctgc acctaacagg acagaccttt ctgttatttc tcactcatcc tcgttgcgga
     4621 catacatcag ttggcaagtt atatgtactg ggcaatttcg tgccacggtg gctgtgtgga
     4681 gttttcatcg aactgtacaa tgtccatttt tgaatgggat atcgctatat tctacggaaa
     4741 tggacatgct cgggcattaa gatccatcaa aagaccgcag acttctaaaa gcaattatat
     4801 acatactgga gttacagagg agttacagaa ttgtctagaa tctcaaaaac ggacaatcat
     4861 ccatattgaa caagacgatg ctttaagtga ccaacagcat gaatcacata tgattattcc
     4921 cagaatgaaa gcccggttgg agagccgcaa aggatgcggg tatttcgaga gctaaaggga
     4981 ataggacatg ttgactagaa agggagggcc atgggagagt tgatgaggta gcacagtggc
     5041 ttccaccagc tcttctgttg tggattatct tgtgtctgaa gatatgttct ggtgagtcga
     5101 ctttaccaca gcaaaggact gcgattaatg ctgaccgaga ttagcttctt gatagtgctc
     5161 tgctacggcc taacaacttc cagtacaaat aaaaccgaaa ctggatgatt attgtcttct
     5221 tgttgtgacg ttgagacatt atgagcactt gtttgctgtt attgggagaa catggctcta
     5281 tcagacatcc aaatttacag cagcagtaca gctttaaact cagttaagac attgattacc
     5341 ggataatgtc tttcaggaag gagaatagtg gatgcactat catttttgca gacatgtgat
     5401 gatcataaat atattttgat atgatgactg ggctgtggct cgcattagag cttggttgtg
     5461 acttctgaaa ggtacgtgaa tgtattaccc ttccaggaga gaacgagaac gaatgaacaa
     5521 ttcacttatc caatacatgt ttgctaacta tagagcacct taggctcaca tggcaccata
     5581 acatgctcga tattgctcgc tgccacaaaa tatctttgtt cacggccatg cactctgcct
     5641 ggttcactgg ttcacagtct acctacttgc tgccccacat tataacttgc tcgctgccac
     5701 gagctctctt tgtttacaac cgggaatcct gcctttctcg ctgccgcaga aggatcctac
     5761 ttcataggct ttccgtatac agcctacttc tcagggaatt ggcccatatc ctccctcacg
     5821 aatggggttg ctccaaaggt ataaagcctt tctcccacca tgtcggttgt ctcgcttttc
     5881 tttactctcc cagttcccac tgctctgctc agacattgtt cgtaacaatg gtttgggacg
     5941 agttggataa ggttttgcta gtcataggtc ttattggctt tgctatcgtt ctcaaaaacg
     6001 aggcacccaa gcttcgaaag tggtatcgca agcgacagga cgccaggcct gatcaaccgg
     6061 gcgcctctgt aatccagcgg ctggcagcga ttcgttcgcc acctccagct ttgctgccga
     6121 tccatttaca tccaccaatc gaactcgact tctgggagaa ttaaggtgcc cttggggaag
     6181 gcactcgtac tgaggacgca gggaacgggg agatcggatg tggtatggaa atgaggcaca
     6241 gtggtagctg cgtgaacatt tcgttggctt gggaaataat ctctgattga gcggttggta
     6301 gagtttgggg gcgcccaccg gtgatgagtc tacccttcta cgtagggccg gtgattagta
     6361 gccttcgggc gaagctaaga tggactcaga tgtaattaga ttgaatgcaa gtattttgta
     6421 ttttgcatgt atgttcttct tctcctagct ctttccaacg gtgttgcttc tctaaactcg
     6481 agtttgagaa aaccgggtta tgagaaacgt aactcgacta ttcatagccg cagtcgtgca
     6541 gtatccatct tatatcgacc cataagtgac gcaagcagag cggcaaggcc cgagagtgct
     6601 gctaccaaca agaatacatc tttcagacct ccaaggtacg cagtgcggag tgctatactt
     6661 gaggccgaat cgatggcttg tacacgcaca aggcctccgg tgagtatttg gttggggttc
     6721 acatcggcaa cagtcatcat gtccagattc cgcttcacct tctcgaggaa tatggtctgc
     6781 cctgtctgca taaataccga agcccccaga catttgaaga acaaggttat agatgtcatg
     6841 gttgacatgt ccgattcatc gacagtagcc tggttcatga tgattggtac ctgaagtgcg
     6901 gctcctatcc caagccctgc taaaatctgg tacgggatcc agtgactcga cagcgtgaca
     6961 agatccaacg tgtatagcag tccggctcct acactgatca gcatcgcacc aaacagcaag
     7021 aacggtgtcg ggtagccgct gataccaaac cctatcgctc caaatactgc cataacgcca
     7081 gctgacacga tcaatggcag ggtgcgtatc cctgagtcct gggctgagtt acctttgact
     7141 gtctggaagt agatgggcat gtaatatagg agcatgaaaa acgcgcccgc caggagaaaa
     7201 atgacaatga gattgacaac aacttctttc ttgagaagca atcgacgtgg aatcatcgcc
     7261 cggtcatccc agaagaattc attcgtgatg aacagccctg tgaggattgg aaaaccgacc
     7321 agacatccaa tcacatctct atcatgccag gacttgctca ctccccactc aaggctgagt
     7381 agaaaacaga gtaatgcacc tcttaatgta atgacccccg gtatatcgag ctggaggatg
     7441 atctctttcc gtgatactcc tacattcgcg cgtcgaaagg gtggccgaaa taagaggagg
     7501 aggacagcga aagtagctcc gccaacaggt acattgatcc agaagcacca tctccaagtt
     7561 aagttgcttg taaattctcc cccgataacg gggccggcaa agctggcgag caagaatgcc
     7621 agacccgtta cgccaaccag tatagggcgt tttttgggtg ggacgcagac cccaatgacc
     7681 gtatatatcc ccgacccaat gcctgatcca cctattcctg caattgctct gccaattatg
     7741 aatgttgggg agttgtggga aatagcacaa agcaaagacc ccaactcaaa catgagtagg
     7801 ctgaggaggt aggtccattt aatatcgaaa agtccgtata gttttcccca tggtgcttga
     7861 gttacagcgc ttcccagaag aaatgcagct ccataccagc caacatcagc agtggagtta
     7921 aattcgtctg tgatctgagg aatagcggtt gagataatag tcgtgtcaag ggaaaccagg
     7981 aacatggcca cagctaggca aagcacaatc acatgcaata acaccccatc gatgtatttc
     8041 tcatgtgcat cagaatctct gtcggtatct cgatgactga ctactttggt ttcatgcagc
     8101 ggagattcgc tgtcaacttg tgacgttgct gtggtcggcg gctttaacgc cgtcaaatca
     8161 ctgggatctg atggcatctt gcggccttgt cctgaagatg caaaacacaa cagctgcagg
     8221 aaggactcag cacgaactgg aatgagcaag gcgaaaaaaa agtctaaaca aatgggtttg
     8281 cttttagtct ttcaccgctg cctcggagaa gtcaaagcat gggtatagac actttcagaa
     8341 tgggctttca cagaagaaat tgactggtaa aatgctaagt ttaaaatttg catagcatgg
     8401 ccccaaagga ttgcttcatt accaacgcag actagggtgg cccttcctgt cctcacaaat
     8461 taccggctgg ctgggaaagc ttatcccata ttatcatttt aatcacttca aaaaagagta
     8521 atgatcgtcc aagacatgct cgtttgcgat ttacccctgc aattatttta caggtcggga
     8581 gtagacacat tactccgtac agtcttaggc aatgtaagtc gaacaaggac tcctcaggat
     8641 tccggaccca catgtctcga tctatgtggc tgcctgacat gcagagttgc cctctctcct
     8701 cggaaaggcc aaagatatga tgtcgatgag ctcaggtata tacgcgaaaa catttcaatc
     8761 gagtcttttg taatcgcaga cggttctgat tagtaggggt ttaatccaag tgtgggaact
     8821 tgtattaagt atagtattca tctgcttcaa gacatgtcta tctattttcc attaagattc
     8881 ttcagctctt aggaaattac gcaagaagct atcgatatgc agaatcatac aagatgatgc
     8941 attgagacac ctcagaacta acgtttcgct tccgatcggt cagatcttta gcaaatgaaa
     9001 atgtcctcat aaattgtatc tgacggatca cataacaagg aggcaacgat aacaacatag
     9061 cgggccataa tatagcatta tatagtagta tatttgtttt cagttaatta ttaggttttt
     9121 tcttttcttc ttctttccga agaaggaaag aaagagaacg agacttacag attcctgctt
     9181 tttcgatgca tggtaaatac ccactgaagt atcagccagc catttcacta aagagtaata
     9241 agtgaaaaga tacagtcgat accccttaca gactccagtg caaaataaac tttggtgtta
     9301 gctatgcagg acctagatac caagaacaac cattgttcat gaaaggaagg gacagggaaa
     9361 gatgggaaat actcccttgt ttcctttctt ttcttttctt ccctgttttt tgttcattca
     9421 ttattactct tacaggaatt atgaaaatat gatacatgga tcatatctag tcaacctggc
     9481 tgaagttttg acaatccctc aagatctgtc tacagccacc tttctgatta tctatgctcg
     9541 attgcagcca catgtttact attgcgttct atcaagggtt tattatattt attaatgtta
     9601 taatcgagtt atcacctact ccatcagaag ccgagaagga agaagatgat gagaaagatg
     9661 aattctgcaa gttctagaca actatactct ccaccagtgg gccggcccgg gcaattgtga
     9721 aaggttagcc aggcacaaag atgccattcc cttgcactca catgctccac tgtagagtag
     9781 acttgtgttg actgggggac tcaggcaccg tttgccaata gtactgcttt gatggtggat
     9841 caatgggtcc gggtctcatt cagctaactt taatgccccc ttgagtggca agtccggcta
     9901 aatagatgct ggacgcccgc tcattttacc aggaaatcag caagccctga gcaaactcac
     9961 aatttacctt tctttggata ccatggcaca ccaagaaact atggccagcg aaacttccat
    10021 atctctacat accctggctt gcgatgccac caagctcgcc ggcacatacg cactgcgcca
    10081 agtgcgggaa gatggtcatt ggtacggtga aatgaaatcc aatgctacta ttacagcgga
    10141 atatgtcttt cttgcgcaag ccttagggtt cagcattgag gaagaccggg acgatctcat
    10201 caagtatttc ctttccgagc aaaatacaga cggttcatgg agcctggcat atgactttcc
    10261 cggggacgtt tctgtaaccg cagaagccta cttcgccttg tgcctgttgg gcctcgaccg
    10321 cagccaccca gcgatggctt cagcgcgcga gttcaccctc tccaaaggtg gcatagccaa
    10381 ggtacgcgtg tttactcgca tgttcttcgc ttgcttcggg ctatttcctt ggtctgcagt
    10441 gcccgaattg ccagccgagt tgatcctact ccctgctgca gccccgatga gcatctacca
    10501 gctagcaagt tgggccaggg cgacagtggt tcctatgctg gtcatccgac atcatcgtcc
    10561 catttatgct ttgccaaatg gaagatcatc ttcaaatgaa tatttggacg agctttgggt
    10621 cgatccaacc gacaaaatgg tcccctattc gccttctttg tggtcattat ggaacgatga
    10681 tcttacagca tttggcttca ctctagccga caatattctg aaagccttag gtggcctgcg
    10741 gtggttccct tcaagaaaaa ttgcacttcg acattgtgtg gcgtggatcc ttgaacgcca
    10801 ggagcccgaa ggcgatatcg gaggtatctt ccctcctctg catgccgcat tgtttgctct
    10861 cgcgctggaa ggttatggcc tcgagtctag ccctgtacgt cgaggtattg acgcccttca
    10921 aaacacctac gcgtggagag acagcactgg tttgagaata caaggctgta tctcgccaat
    10981 tttggatacc atcctcatga ccatcggcct gattgactca agccttccgg ccgaaagtcc
    11041 cctcgttgca cgatcgtcac gataccttaa ggcccaccaa cagcttggaa acgagggcga
    11101 ttggagggtg tataacggaa atgtcccatc cggcgggttc aatttcgagt actttaattc
    11161 gtggtatccg gatattgacg atactgctgc ggcaatcttg gcgatggtga agcaggatcc
    11221 aaacctatta gacttaggcc ccatactatc tgcagttcaa tggatcctgg gattgcagaa
    11281 cgatgacggt ggatgggccg cattcgaccg ggagaacaac tacctgttcc tcaacaaaat
    11341 ccctttcagc gacatggaca gtttttgcga cccatccacc gcggatgtga ctgggcgtgt
    11401 cattgaatgc tttggcctgt tagctaagag gggttctgtg ctgtccagaa atggtaaaaa
    11461 cccaatccct cggttcttca tcgacgacat gtcctcagct actgagcgtg caatcgactt
    11521 tctttcaacg gaacaagagg ccgatgggtc atggtacggc cgctggggct cgaactacat
    11581 ctatggaact agcgcggtac tttgcggttt ggtctaccac ttggaaggct gggatgatac
    11641 gtatcccgtc atggaaaaga ggcacaaagt ggacactcat gccgccctgg actggctcaa
    11701 aagacaccaa aatcccgacg gtggctgggg cgagcgcctc gaatcctatt atgaacctcg
    11761 tctcgcaggc aacgggccat ccacagcatc gcagacggcc tgggcattga tgggcctgct
    11821 tgcatattta gcccctacag atgagtcaat cacccggggc attcagtacc tttcacggac
    11881 acaaataaag gagggggaac tggcggggtc ttggaaggag gatcactaca ctggcactgg
    11941 ctttccaaac catttctacc tttgctatac cctgtattct caatactttc caatgatggc
    12001 cttgggtcgg tataccagtt tgtccggtta cagaccacta gaaaatctgg aaagcacagt
    12061 ggaagaccat aaaggcaact ctagtgactg ttgatgggta gggtttgacc gacccgatgc
    12121 ccggtatgtt aaatttaata tcaaacttat tagccttcgt agcaccgtga aaacttcaca
    12181 gaaactaatc ccaggttttg acctaatgga tattgggaac gatgtggtgt ttggcaatcg
    12241 gtcgtgcctg ggcacggtgg acaggctggg caggaagccc attgtcatca aagatggggc
    12301 catgctgggg gaccgatctg tggggcttcc gagggtaaac attggaacgc gcacgatggt
    12361 gggctcgggt gcattgctgc ggcggaatgg ctcctatctc gatgaccgca ggagctattg
    12421 ccagcgctgg cagatccagc gcaccatcga tatcctcatc gaggagtctt ttggcgggag
    12481 gggcatccct gtcgttaatc agcgggacag cgtacctgag ctggttctat cgggcgatgg
    12541 gggccaagat cgggtctgat tgtgcgttga gcgccaacgg ggaaccgcac atatttctca
    12601 ccgagccgga cttggtgacg ctgggggatc gggtgacggt ggatgatgcc agcctggtat
    12661 gccatctcaa taccagaggg aattttgagc tgcaaagaaa caatggctct gtggggcgta
    12721 cattatggct gagtgggcag gtatacaggt accaatctaa caggaaatgc tgaaataata
    12781 gtaggatttc cacttcagta tcgcccaagt agcagctctt gttcttccag cttttggcag
    12841 atgtacagcc gcccaaacaa aagcttcatc ctccttccaa tcacacaaaa atgcccatag
    12901 gaaagtctca gatttccccc ttcccaacgc acatattgtt ctcagctact acaccttggc
    12961 catatttaag ccaaggcatg atgcagggaa taacacccct ttcaaaacat ccaaccaggc
    13021 agaatacgtt gcaacacacc acctgtagca gccccggggt gcggcagatg tcccagcgga
    13081 tggtctgcgc acttgcgcac atccgcgaga gtgactcctt cgggaagatc ggctgggtcg
    13141 actttcatta ctccgaggga gccgcactct tcttcgacac tgaggtcggt ggatacggcg
    13201 ctggtggcgt agatggtgag aaggaggtag gtaaggagtc tcattttggg gtgtctttgt
    13261 tcgaggtttg ggtgacaata aaggtattga ttttgctgag ggtgaaggtg ggagaagaga
    13321 gagtatgtag attttagttg gttttactag tagtagtcta actgtgtggc ggccctaggg
    13381 cgaaatttgc tgctgcttta aatactggcg tggaaaataa acagacaacg tggcaggact
    13441 ggccttgaca gttgcctgct gtctgtacga cctattcctt tgttccatgg tgtattgata
    13501 gccgcctggt attgatgggt ccaagtggat ggatgatgcc aatgactcat gggaatcatg
    13561 gtgattgatt tggtaggttt taacttgagg atttgatcta cagggatacg attcccgtga
    13621 atgaaaccaa cactcggtga gacttgatta gttagtctat atctgtctga ctacttagtt
    13681 tctcttggca gggtccacaa cacaacatga cattcttata atgacaagta actcaggaca
    13741 agcctggcct attcgcagtg gctgactgaa gtcaacaata tgagagctca ggattcgagc
    13801 aactccctgc aatgaatgtt tgtgacagcc gtggaaggtc gggttcgaag atctgtgttg
    13861 atgggtctag aatacgatcg attatatgca ccacacccta tgtctagtat taataagagg
    13921 atagtattcg ccggtattgc aaggaaggaa tgagttcgta cactagtaac cgggatatct
    13981 gattccacca catttgccac ttgattaaga acaatcgcac catcctgcat ttgcgatccc
    14041 acaaagaggt aggtggcagt ctaagctaga catcagttga ttacattgta atcggacggg
    14101 tattctcacc tgaaaacgct gcaaagtctc attgaaacta ctcgatgtga gcctagagtt
    14161 aggcacatag tggtgtatga tggtgtttcc cagccaccat ttccctttcc tatgcaggat
    14221 cagcaacgtt gatgcaagat cagaaagatt gatctgacat acggagtcgg ctcaaaacta
    14281 tcaaagtatg ccccggtata taattcaaag gcatcgttgt tcggtgcaaa gaatgtaaat
    14341 ttccaatttg gatcggtgtc aaacgcttgt gcaaatccgc caagttcatc gattttctca
    14401 gacaggatgc ttaagtccga ccgagatttg atgaaatcca caagagtcgt cacattcaag
    14461 gagctggaag tgacatagcc ggggatgttt cggtagttca gaggatcagt tgtggctatg
    14521 actggactaa tcaaagaaag gagtcctata attggagcga atgagaatat catattgtga
    14581 gtctcgttat ctggataagt tgaggtaaca acttcagcac gcgagtcctg ggaaaataaa
    14641 gagatacctc agaggcttca tgatgcaatt tgttcagggt cactagtttg gccgctggat
    14701 ctcccggagc atctccgcaa cttcatcccc ctgacccggc caatgagatt ataccactcg
    14761 gctgaaaggc tgcagcctta ttagctagta tctttactct acctagcccc tttactccgg
    14821 tggggattcc ggacaagctc cggaggttgc atagaaaaga tctgctgcag ttgatctctt
    14881 ataactaccc caaaaatggc ttcccggtta ctgcacatca cgtacccttg ggcaaacccg
    14941 gcaacatgat gaaacgcaaa tctcagctgt catcattcac cttagtgacg gcggcaattt
    15001 taccttttgc ccattttgtg atgggaggca caagtctcgc acaaaagcct cagatgggct
    15061 ggaactcatg gaacgcattc aaagcgacgg tcaactatac gatagttcaa gaagttattt
    15121 cgctgttcga tacgcttggg ctgaaagagg cgggctacga gtacgtgctg cttgatgatg
    15181 gatgggcaag ttacaatcgc acgtccgacg ggtatcttca agccaatgca acatcctttc
    15241 ctcagggtat taaggcactg gcgcaagagg tgcacggtaa gggcctaaaa ctaggccttt
    15301 atggagatag tggtcattac acctgtgcgt ggagaccggg aagctgggga tacgaagagc
    15361 gagacgctca aacgttcgcg ggctggggcg tcgactacct caagtacgac aattgtggcg
    15421 gatttcagtc gatgacagag gcccctcaga tacgctttgg ggcaatgaag aatgctctca
    15481 cgctttcggg tcgagatatc ttctattccg tgtgtggatg gggttatcag tttccctggc
    15541 actggggagg aggtgagata caccctgcaa accaaccaat cttctacctt aagatactca
    15601 ttccacccgc ctgcagatat tggtcactca tacagaatgt ctggtgacat tacaacaagc
    15661 ttcaccaacg aaactgagtg ccagtgcaag accgcctact gtctcaatac cgggtatgcc
    15721 ggttgctcag tactgaccat catcaacaaa atgaaagaaa tcagccaata tcagacgcca
    15781 ggtcattggt tggatatgga catgctagaa gtcggaaatg caaatttcac actcaaccag
    15841 cagcagacgc actttgcatt ctgggcggcg ctgaagtctc ccttgatcat tggtgctgat
    15901 ctcagcaagc tttccaatga cagtttagct gttctcacca acaaggctat catttcgatc
    15961 aatcaagacg cgctggggga gcctgtgacg tatcgcgaag cacatagcaa agaaggtctc
    16021 ttccaggtat gggctgggaa ggttgaggac ggatatgttg ttctgctgct gaatgagaaa
    16081 agctatccgc aaactgtgtc tctgagcttt gccagtttgg gacttggctc acctcagaag
    16141 gtcactgaac tttggtcggg gcagactttg caggatctta gtaagttcaa tgggactttg
    16201 gggtcttatc aaactcttgt tttcaaagtg aaggcatgaa aaactgaggc atggtgtggc
    16261 tttaaactgt caaccttcat cttcataaca tattttctta ttatattcgc tggaagagtc
    16321 tgtagatttc tgcaaaccca caaagtagac aaatagacat attgaatata aagtaggctt
    16381 gattatgtct caaggctgaa attacgctcg attgtcttct aattgcccgc cgtattccca
    16441 aataagacaa gtttgaggac ggcaaatccc agtaaccaca attgttaaat taggtgaaaa
    16501 gcatgagcct ttgagcagag atataccact acatcccatt gtgatctttc tataagaaat
    16561 tcgtacacat tgcttgtgcc aaccgcccaa tatggaagta gttggaagga aaaataggcc
    16621 ttgaagaaat acataccggc atatgccaag ctccgtcctc attgtttagc gcgtaacgct
    16681 tccgcgaaca tatcaatcgg gggtgacgga ggtgaggatg ttccatctca tgtccctgca
    16741 gtctcggctg atagtggcaa cagttcattc cacaaccctc gtgtcgaggg agtggcatgt
    16801 tggtaagtgg tatcccaagc ttctttggct ggcccctgaa atgttaagtt gatgctaaat
    16861 tttggttctt acttcttgtc tctgacaggt ggactgattg gtgggtcgac gggttgcgtg
    16921 gctcactgga tcccgtgcac tagggttcga caactgcctc ccttttcgtc cgccacacat
    16981 taactaccct gcctggactc cgtagatagg gataaagtac tcatgatcaa atgaattgca
    17041 ggtttctcat gacgcactct ctcacgcgga gagagtcttt agtgctcctg cgcatacgta
    17101 agttcgccgc cgatccttcc ctgaagacat ggaccctgga tattaactgc aggtgggtct
    17161 gtcttgcact ccgcaggaaa tattttctcc tatttcctgt acatatcggt ggaaccaaac
    17221 cctagaactt taaaagaacg gaaacgatag tctaataaga atccggtgct attcgagaat
    17281 ctatacgcgc gatagtgaag ggcattttct gtacggttag ggccagcgcg ccccaaatct
    17341 taatgaagac tcaatagtag cgacgagcct ctgcgtggac tgacaagcgg aagttcctgg
    17401 ccattatcta tttaattatg tcgatccatt gcctattcga ctttcaatta agcatatcga
    17461 accacttgct aagtcattct gggaaaatct ccggcgtcgg acactcgccg gcaattaccc
    17521 cgcccgccga caggaagctg attggcgcag cgtatgtctc catgtctacg aactcaacgg
    17581 tgcagaggat gtgccaggag tggcatgaca agtgcagatt gcggggaaga caattccccc
    17641 atgggggcgt cggtctttgt gcatgcctga ctctgtatgt cagacatctc cttcctggag
    17701 acaatgttca catggtaaat ttctcaataa tctcaactct gcctacccga tgccccccaa
    17761 atcccatccc gcaacagcca acgccaacgt aggagacttg ccagagacaa ccaacaaagg
    17821 agaggaggag attccagcct gtcagttctg tcgcaagaaa aaagccaagt gcaatcgagc
    17881 gcagccgtgt tcgcaatgta tgcgatcgga tgttctttgc gtctacgatg atcgacggac
    17941 gaagcccggt ctccgagctg gggcggtcga ccagctctat cggcgcgtcg agacgctgga
    18001 gaatatgttt ttgggtcagg agatgctctg gcagcagatg tggaaggctt tattcccgaa
    18061 cactgagccc ccgcgatccc tggacaaggg aaccacggca gccacgaccc tgacggagcg
    18121 tcgggagcag ttgaaggctt cattacagga gcctccaccc ttagcagcga agaggtcact
    18181 tacagtggca gacgccgaca attctgcacc gctggactgt gttcctctcc cagccaaacg
    18241 cgcccgtgtg gaggacgaag tggctcccca tgcggctgtc ctagagcccg agcctttctt
    18301 ggccaactct ttacctgaca tcgtcttgaa cgaactggtg gatttctact ttgtcaacat
    18361 ccatccgtgg ataccgatac tacacgttaa gagattccgt gagcgcatgc gatcgccgga
    18421 ggaacgaggg catatcaatt gcatcttaca tgccatcatc tctgtctgtg cccgcttttc
    18481 acaaaatggc ccaaatggcg atacgttgaa cttaaaagag atcgccaaga aaagtcggca
    18541 agaggtaata ttgcaaagca ctgaaacctt ctccgttgag aatctccaag cgctagtgat
    18601 cgtcgcattt gagacagtga gcaagaggcc cacgccatgg atatccggga acaagtagac
    18661 tgatttcatt cgaacagatt aatcgcggcc gtgggccctc ctcatggtct atcattggca
    18721 gcatggcggg aaccgtggag cagcttcagc ttggcgtgga agaagatgac ctgtatcgtg
    18781 tcaagcgcat gggagaaaga ctgatcaggc gcatggtttg tctgacacca tctcggtcat
    18841 ggagtgaagc agaagagcgt cgccgtgtat tctgggcagt ctttctcatg gaccgcttct
    18901 gcagtgtctc gacaggctgg aagatcagtc tgaggaatgc tgatgtgaag cgccgtctcc
    18961 cgtgtgaagg tgctctgtgg gaaaaggaac aagaggtctg caccccgtat ttcggcatct
    19021 ctgatttcaa gaacacttcc atgcctaata gtcactcaac ttcgatggat ggctctgaag
    19081 aacaggccat cggcgcattt gcctacatca tcgaggctac tgagtcactg gccttagtga
    19141 ccaacttcta tctccaccac gtctttctga ttaacgatgc cagcaaggca cgattatggc
    19201 tcgtcaaatt caaggaacta gatctgcgac tgattcagta cgtatcatct cttcccaagg
    19261 gatgtctaaa caccagtgat gctgacgcgc gcagatggaa aatccatttg cctcccaaat
    19321 ggcgcgaagc ctgcgtccta aatgaacaca gagtcatgga ccccaatctg actctggcac
    19381 acatcaccca caatacggcg gtaattctgc tgcatcaggg catcgcctat ccaccatcgc
    19441 attggcagta ctgtcccatt aagctcccat cagcatcctc tgctgatacg tgccttgaag
    19501 cggcttcaga gatagcaact attgctaata aattcctgtc cttttctccc atcttcacga
    19561 atccccaatt ttctttttgt ctattcatcg ccggccgcac actcctcgca cacgctaggt
    19621 acaatagggt accgccttca cccgcactca acaccctcat tgcaaacctg atggagatct
    19681 cgcagcggtg gacaagacac catgacgcca gcgaatccca gcaagaggag agcctggcat
    19741 tcaagtttgc cacccggctc atcgaagccc agcagaatcg aaccagtgca tctcgtccga
    19801 gtctggatat tcgcacgact gcgtattcag atgaatcaaa agaggagatg tacaaagacc
    19861 ccatgagaac aaaccaggat gatctcccag actatgaatc gcttagcaga ccactgcagc
    19921 tggcttcatt cccttcgcag gagtccactt cctgcacgtt cgacccattc agtctggcct
    19981 tcccaccgct gccaccagcc tttcagcagg atttttcgcc cactggtctc gacccgctct
    20041 ctttctataa tatgcaattg ccgtcggagt ctatgtcttc gcctcttggt acgagaagcc
    20101 acggatcggg ttctcagcac gattcggaga gttccatgac cagtctcttg ccgacggata
    20161 tttctcatct cttcgatatg acgtctagtc cggggcagag aatcagttat tacggcaata
    20221 cacggggagt gaccaacaat tcgatagtcg agggagccga caattagacg agtaacagaa
    20281 cttgcgtgat catatttcct ctcatttacg ttgtgcctct atattttatg tctacttccc
    20341 tgcccctcag agggggttct ttaatgcttc tactccctgc cacactcgct gccttatata
    20401 tgaggatcga ccaagtccat ctcaaggagc atatttccaa acagcaagaa ataataatca
    20461 gcatagacga gaccatggtc cgaccacctt cgcggagcaa actcatagtt attgattgtt
    20521 gcgcccgtca gtatagtttc agcaacatcc ccaaccaccc tcagcacttc cgccccgttc
    20581 cgagtctcag tgtgatgcgt cgagcactgg tctgcgtaca cggagatttc tgacgcagga
    20641 ccagcctcga accgcatagg gggattcaaa taccccacaa ccgtacaatc aaccagcttc
    20701 atagcagccc gaaggtagtg gttagccgcc tcaacatcat gcatcttctt gtaagcctta
    20761 tagagcaaca acatcccaca ggcagcgatc atcgcagcag aggtatcgcg tggggaggtg
    20821 tcagtaacag gcgcatcaaa atcccaatat gggacgccat catccggcaa tctcgcaaga
    20881 aatacatccg ccagtgctct agcagtgcga aggaatctca tctctcttgt ccactcgaat
    20941 gtctgcgcga accccatgat tccccacgcc tggcctcgtg cccagcagct atcatcacta
    21001 tatccctgat ttgtgaattt tttcttcacc tcccccgtct ccaggtccag atcaacaacg
    21061 tgaaatgtcg tatagtcatc tcggatatga tgcttctgtg tagtgatcgc atgagccctg
    21121 gctatatcat aaagcctccg acagcctgtt tctctcgctg cccagaaaag caaatccagg
    21181 ttcagcatgt tgtcgatgat aaataggaag tcctgcgacg aatttctgta tgcatagcgc
    21241 ttggtgatgc actggtccca gctacgaata cactgggttg attcattaaa gcgactggcg
    21301 agggagtggg ctgctagtat gagagtgttg taggctgctg ggtctcgatg cagggtccat
    21361 gctttcatcg cccaaggggt gatcatgaac cctaggtcgt gagtatcctt gcgaagggcg
    21421 ttttggtgaa ggtttgctgt ccaccagcgg cagaggtgct cgtgttggag gggatggggg
    21481 tggaggatgg attcgctggt ttgtcgttgg agaataagat gccggtcgcg gaagagagtg
    21541 ctgcgttcta agaggaggta taaagagcct gggaagaagc cggaggtcca gaagtcaagg
    21601 gttcggtaga tatatgtggt cttgtcttcg ccggtatatt cggggtagaa ggttggaggg
    21661 gttgtctatg tagaatgtat tttgtttagg atagtgtgaa acatttagcg gttcggcgaa
    21721 ataactcaca ctacccatcg ccttggatgc gacgaaccag accttggcta ggagggattc
    21781 tgagaagagg gcttcgagta ctcgcgccca ttgcttggta gggagtactt cggtgccgtt
    21841 gatggttgtt gggggtcccg cttcgataga catcgttcct agtcaatata tggtttgcac
    21901 gctatagaga ggaagacttc aagataaact gaatgagatg caagatacaa ggttgaaagt
    21961 gtgttcaaga ccgtccatct acaagatctc ctgctccatt tgaggctgta tgcattagcc
    22021 ctcggaaggg ggtccgggaa ttcctccgcg cgagaactcc ctgctaaaat gcactggaca
    22081 ggcatttcgg gctatctccc ggagtccctc cgacgagcct agaagacact cgttacagct
    22141 aagacttccc caccatcggg gctcttcatc accctgaatc tagggaatac aagtccaaac
    22201 attaatatct tatctacacc tcaattttgt cttcctgacc cacaaatccg ctgtctccaa
    22261 atccacaatg gcatccaaaa tctccgatat ggacgcaaca acggccgatc atctcgaatc
    22321 gacagagaaa aaagacccct atgcggcaga cccaggcatt gaaattgacg aggcaactga
    22381 taaacgactc ttttggttga tcactcgtcg tatcctggtt atccaaattg ttacctattt
    22441 ctttcagtcg cttgacaagg gcattctgaa ttatgcctct atcatgggta tcaaggacga
    22501 tgcacatctg gtcggacaag aggttgtaca ccagtcttta atggtacata acaattggc
//
