LOCUS       KZ851920.1             24990 bp    DNA     linear   PLN 20-AUG-2019
DEFINITION  Aspergillus niger.
ACCESSION   KZ851920
VERSION     KZ851920.1
KEYWORDS    .
SOURCE      Aspergillus niger
  ORGANISM  Aspergillus niger
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Eurotiomycetes; Eurotiomycetidae; Eurotiales; Aspergillaceae;
            Aspergillus.
COMMENT     'Annotated using funannotate v1.6.0-df4262f'.
            ##antiSMASH-Data-START##
            Version      :: 5.0.0
            Run date     :: 2020-11-02 07:38:58
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 242444
            Orig. end    :: 267434
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..24990
                     /aStool="rule-based-clusters"
                     /contig_edge="False"
                     /core_location="join{[255550:>257434](-),
                     [253802:254039](-), [252444:253725](-)}"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(join(10001..11281,11359..11595,13107..>14990))
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     cand_cluster    1..24990
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..24990
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="2"
                     /rules="(Terpene_synth or Terpene_synth_C or phytoene_synt
                     or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps
                     or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /tool="antismash"
     CDS             complement(<560..1606)
                     /codon_start=1
                     /db_xref="InterPro:IPR013536"
                     /db_xref="InterPro:IPR029071"
                     /db_xref="PFAM:PF08325"
                     /locus_tag="M747DRAFT_371395"
                     /note="MEROPS:MER0215827; EggNog:ENOG41"
                     /product="zinc metallo proteinase"
                     /protein_id="ncbi_M747DRAFT_371395-T1"
                     /transl_table=1
                     /translation="MTDTESPTGGTLTLQIHHRNASHSLTLPTTSTLTDLTELISSTLQ
                     IPPTHQKLLISPSPGMLKHPFPPTPLQDLLPLTSPKFKLTLLGTPPRDIESLNTHGTEL
                     KARAEARDRAHRLYAAKPTPSSTSSNISKIHTLANSANGSGSYTFHRCVPLPHLPNPSK
                     SLTFLERLRDDPGIKSAMQKHKFSVPLLTEMDPAEHTTSESRTLGLNRNKGEVIELRLR
                     TDAYDGYRDYRTIRKTLCHELAHCVFSEHDRDFWDLTSQIEKEVERGDWTKSGRTVGDQ
                     EFYNPGDWEGVREQGLVVDEKGWTGGQFVLGGGGGGDGRGESRREVLAKAAEERMKRAR
                     EREGEGKS"
     mRNA            complement(<560..1668)
                     /locus_tag="M747DRAFT_371395"
                     /product="zinc metallo proteinase"
     gene            complement(<560..1668)
                     /locus_tag="M747DRAFT_371395"
     mRNA            complement(join(<2172..2247,2299..2726,2791..>3156))
                     /locus_tag="M747DRAFT_342701"
                     /product="mannosylphosphate transferase"
     gene            complement(<2172..>3156)
                     /locus_tag="M747DRAFT_342701"
     CDS             complement(join(<2172..2247,2299..2726,2791..>3156))
                     /codon_start=1
                     /db_xref="InterPro:IPR007074"
                     /locus_tag="M747DRAFT_342701"
                     /note="SECRETED:SignalP(1-21); EggNog:ENOG41"
                     /product="mannosylphosphate transferase"
                     /protein_id="ncbi_M747DRAFT_342701-T1"
                     /transl_table=1
                     /translation="MNPRGLLAVLTCAIWSAVATARPSPAEHSNHGSFVNRNDPDPLWQ
                     KYGLNKSDEFKYFHEPGRDDTLGHYDSRFFQGEPVPDAERSITLTHMIRAYLNFFEDNG
                     LETWIAHGTLLGWWWNGKIMPWDWDIDTQVMDTTLFHLADHFNQTVVQYTTTDPDVERR
                     YLLDINPWARQRDRGMGLNIIDARWIDISTGLYIDITGLSRLTAEKPTEWECKNGHKYQ
                     THDIYPLRRSTFEGVPAKVPFRYDGVLTEEYTKKALTNTQFHNHTWDAELEEWVLDVPA
                     AMDDRQYE"
     mRNA            complement(join(<5730..5982,6037..6152,6217..6530,
                     6596..8150,8235..8789,8850..9424,9479..>9794))
                     /locus_tag="M747DRAFT_353604"
                     /product="ATP-binding cassette transporter"
     gene            complement(<5730..>9794)
                     /locus_tag="M747DRAFT_353604"
     CDS             complement(join(<5730..5982,6037..6152,6217..6530,
                     6596..8150,8235..8789,8850..9424,9479..>9794))
                     /codon_start=1
                     /db_xref="InterPro:IPR003439"
                     /db_xref="InterPro:IPR003593"
                     /db_xref="InterPro:IPR011527"
                     /db_xref="InterPro:IPR017871"
                     /db_xref="InterPro:IPR027417"
                     /db_xref="InterPro:IPR036640"
                     /db_xref="PFAM:PF00005"
                     /db_xref="PFAM:PF00664"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 217.5; E-value:
                     5.5e-66)"
                     /gene_kind="transport"
                     /locus_tag="M747DRAFT_353604"
                     /note="GO_component: GO:0016021 - integral component of
                     membrane [Evidence IEA]; GO_function: GO:0042626 -
                     ATPase-coupled transmembrane transporter activity [Evidence
                     IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATPase activity [Evidence IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /product="ATP-binding cassette transporter"
                     /protein_id="ncbi_M747DRAFT_353604-T1"
                     /transl_table=1
                     /translation="MSSQGIPLKVIQPTADTTHKAEALQSQIHIVRSTANIFTIYRTAN
                     TSQLCLLFLSGCCAIVAGAAMPLVTVVYGNFAREFITGDNNAPDEIRHHVQSLALYLVY
                     IAIGSLITTAISTFGFNTIGEQISRQLQQKYLASALRQNMAYFDVVGIGELTSHMDQDM
                     KLIQAGISQKVGELLSGLSGFVVAIICAFIQNGRFAGIMISQPIALLTLIGVMGGFLSL
                     TQRRSLAQYVRADNLAQEVLSAMRSVIASRSQERYGKRYYEALRHPAELDFRERFIFGM
                     LVAGSVMVMHWANGLGFWQADHLLRQGHCTISEVLTILYAMAVAGGMLSQALPSIVNIT
                     QANAAVSRVFSVIERESPIDPSASTGVTHSRVRGDISFEDIHFTYPSRPEGKVLKGVDF
                     VVPAGHTVAFVGPSGSGKSTVFALLERLYHPHSGRIMLDGEPIDAMNVAWLRSQIGYVG
                     QDVTLFRASIHDNIAYGLPKAAAELVIEAAKVAQIHDFVASMPKEYNTMIEAHGSNLSG
                     GQKQRLAIARAIISQPAILLLDEATAALDSRCEKAVQEALDKVVKGRTTLIIAHRLSTV
                     QNADKIIVMKDNQILGQGSHAELLSTSAMYRELVRHQALEAFHRSEGDRLIRQRPHSLS
                     THEEHSKDILVKFDTVDIPEDGLLAVRSSSSSVGRVWSLNRPEFPYIAAGVSFSVLAGI
                     TYPVQAIFFGNGIMSMINPSLSTGGHNVEFWATMYLTLGIIAFVVYSVRGYCFAVSASQ
                     LVLRARSQLFKHLLVNDLPFFQDKDNSIGALVSFLASGPRQITGVSGTSLGLVAESIVM
                     LATGITIGCIFGWKLGLAATATVPLVVVSGFMQYHTVARVQEYIKRDTSAVAIAHEALS
                     AIKTVTVLGLQKAISASFESASHRDSQRKYWLMFAATYECTTSLRALSIAFVFWYGGTH
                     LIATGEYNVQQFFICFAATMWGSQSASVLFAHAPDIAGSQAAGARLEELMRAGISAATH
                     RKLNNGDADVPTLKDVSLNAPAGAFIALVGATGSGKSSVINLLERFYTGETGAIALDDM
                     PIEQYNLDSYRGYLALVDQNPCLIGETLSDCLQSGELVVLDDEILAALEDVGLADYVLS
                     LPQGLSTPVMANGSTLSGGQRQRMAIAKALLCRPKILLLDEATSALDSASEELVQRTLQ
                     RVMKGRTVIAVAHRLKTIVDADEILVFKHGHIVERGTHKELMQLEGEYWQMARLQQVMG
                     EA"
     mRNA            complement(join(9641..11281,11359..11595,13107..>14990))
                     /locus_tag="M747DRAFT_261923"
                     /product="squalene cyclase"
     gene            complement(9641..>14990)
                     /locus_tag="M747DRAFT_261923"
     CDS             complement(join(10001..11281,11359..11595,13107..>14990))
                     /codon_start=1
                     /db_xref="InterPro:IPR003480"
                     /db_xref="InterPro:IPR006400"
                     /db_xref="InterPro:IPR008930"
                     /db_xref="InterPro:IPR018333"
                     /db_xref="InterPro:IPR023213"
                     /db_xref="InterPro:IPR032696"
                     /db_xref="InterPro:IPR032697"
                     /db_xref="PFAM:PF00432"
                     /db_xref="PFAM:PF02458"
                     /db_xref="PFAM:PF13243"
                     /db_xref="PFAM:PF13249"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: terpene_cyclase"
                     /gene_kind="biosynthetic"
                     /locus_tag="M747DRAFT_261923"
                     /note="GO_component: GO:0005811 - lipid droplet [Evidence
                     IEA]; GO_function: GO:0016866 - intramolecular transferase
                     activity [Evidence IEA]; GO_function: GO:0016747 -
                     transferase activity, transferring acyl groups other than
                     amino-acyl groups [Evidence IEA]; GO_function: GO:0000250 -
                     lanosterol synthase activity [Evidence IEA]; GO_function:
                     GO:0042300 - beta-amyrin synthase activity [Evidence IEA];
                     GO_process: GO:0019746 - hopanoid biosynthetic process
                     [Evidence IEA]; GO_process: GO:0016104 - triterpenoid
                     biosynthetic process [Evidence IEA]"
                     /product="squalene cyclase"
                     /protein_id="ncbi_M747DRAFT_261923-T1"
                     /sec_met_domain="terpene_cyclase (E-value: 1.2e-25,
                     bitscore: 84.1, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MTLREEGHKEGITPGKEQLTSDIEHSLKLATEYALSSIRSDGHWC
                     GELRSNVTITAEYIFLRHALGLDLRTDNAAYCRYILSQQNCDGSWGLAPEYPGDVSTTT
                     EAYLALKLLGTSPDMPAMQQARAFVRKAGGAEKVRVFTRIFLATFGLFPWDAVPQLPVE
                     LILLPSSCPINMYTLASWARGTIAPLLIICHHQPVYALPEDYLDELWLDPTDKNVPYGS
                     SLRDLLSRGDITGLAFSVVDNLLYYLNGLRSVPLLRSYARRKCIQWILERQEPTGDWAG
                     IFPPMHASIYAFVLEGYELNDPPVRLGIQALENFAWEDEKGKRIQACVSPVWDTALMSI
                     GLCDAMSPDKQILQQAITWIRNRQLLKPCGDWRIYRSKLAPGGFSFEYENSHYPDVDDT
                     AAIILAQLKQDPQSVASDSVIAAATWILGMQNPDGGWAAFDVENDKLFLNKIPFSDMDS
                     LCDTSCADITGRILEAFGLMMKRELKRPVLSPMLRHACIRGITYLASTQESNGAWFGRW
                     GCNYIYGTCHALCGLAYYMEDDKRVSGLVAPALQWLKSKQNDDGGWGEPLLSYRTPGTQ
                     LQQQSTPSQTAWALMGLLAHLPLTDPAIERGIRWLVCSQQPEKGNGASWPEAPNKMMDF
                     FPIFNRARPATVPTDKVVPLRYWDDLDYLRRLCHDFTFRFDDVLDASKLDAALARLTEI
                     GNWGQLGARLRLNDQNRLEYHIPAEYTKARPAYNFTTNEYGLRISEHALGKQLPKAGQD
                     QSVLSPSPAVFAPIVRHPDSPRKLADWIYTDRPQLHIHVSVFQDATLVTVSYVHTLFDA
                     IARTTFFKAWIAVLRGREDEVPPFIPFEHDPLRTLGTEAPVKPYSNFGRALSGLSLVIF
                     GLRYLWELLWYQKEEEHPIRLPRRCVEQLKESARKELAAMSPDNEAKAPFLSEGDVVMA
                     WWVRTITTALNPAPNRTIMVMNVFNVWALFEEWFPSGGAGFIGNAFFYSYTLLVASQVI
                     QDASLAYVASKNRKALMEHRTKEQVQALTSMQRASFTRTPPVVGDANLLFMACTNQHKA
                     RYFELDFSAAVVAPGVPLSERPHALGRPSYINDIETCQGYPTRNVVRIIGKDAAGDYWL
                     LFKTRPGAWAAIHRQLVALLELDEQK"
     mRNA            join(<15424..16537,16594..16860,16918..>17066)
                     /locus_tag="M747DRAFT_323937"
                     /product="cytochrome P450"
     gene            <15424..>17066
                     /locus_tag="M747DRAFT_323937"
     CDS             join(<15424..16537,16594..16860,16918..>17066)
                     /codon_start=1
                     /db_xref="InterPro:IPR001128"
                     /db_xref="InterPro:IPR002403"
                     /db_xref="InterPro:IPR017972"
                     /db_xref="InterPro:IPR036396"
                     /db_xref="PFAM:PF00067"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 238.1; E-value: 3.2e-72)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="M747DRAFT_323937"
                     /note="EggNog:ENOG41; GO_function: GO:0020037 - heme
                     binding [Evidence IEA]; GO_function: GO:0005506 - iron ion
                     binding [Evidence IEA]; GO_function: GO:0016705 -
                     oxidoreductase activity, acting on paired donors, with
                     incorporation or reduction of molecular oxygen [Evidence
                     IEA]; GO_function: GO:0004497 - monooxygenase activity
                     [Evidence IEA]; GO_process: GO:0055114 -
                     oxidation-reduction process [Evidence IEA]"
                     /product="cytochrome P450"
                     /protein_id="ncbi_M747DRAFT_323937-T1"
                     /sec_met_domain="p450 (E-value: 1.2e-42, bitscore: 139.9,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MTALLLSGPSRPNGLLLALAVIAVGVAITLLANNFNQRRRSRQLE
                     RLHGCEQPPNESDRFQYDIFGIAKSIELAYHFRRRTSLPYTNALFERYGETYASNVLGY
                     RLLFTCNADNIKHLLSAAFVDFDSSPLRRPLFEPITPHGIFTLDGAAWKTSREQLRSRL
                     SDLRKAIDLSLCEQHFQAFLRHIPLNGRPFDIQSCAFGLSLDMQTLFSLGESIDALSST
                     QSQEKKQFFKDLLLVKNRIVQDGFRGPLRHLVPKRSFLQACKSSRAYVMTRVVRDLERQ
                     GSVDKEADELPTLESYSDTNRVSQLTDQALSILLANDSMSTTLSGLFYCLAQNERVVHK
                     LQASIIDAIGLTPPTWGQLGTLQYVRWVLQEAMRLFPPVVLNARVANKESTLPTGGGAH
                     GDKPVLVMKGDIVVFSTWARHRLGKDFGEDPEEFRPERWEQLSGDMAGYIPFNKGPRIC
                     PGQHYAMTVLTYIVARIFQTFSTVSDYNARPWTERISMTFENENGVLVGLS"
     mRNA            complement(join(17318..17460,17537..17886,17956..18440))
                     /locus_tag="M747DRAFT_296702"
                     /product="short-chain dehydrogenase/reductase"
     gene            complement(17318..18440)
                     /locus_tag="M747DRAFT_296702"
     CDS             complement(join(17392..17460,17537..17886,17956..18400))
                     /codon_start=1
                     /db_xref="InterPro:IPR002347"
                     /db_xref="InterPro:IPR036291"
                     /db_xref="PFAM:PF00106"
                     /db_xref="PFAM:PF13561"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     126.1; E-value: 2.6e-38)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="M747DRAFT_296702"
                     /note="EggNog:ENOG41"
                     /product="short-chain dehydrogenase/reductase"
                     /protein_id="ncbi_M747DRAFT_296702-T1"
                     /transl_table=1
                     /translation="MSTDRKTVLITGCSDGGIGAALAETFHDHRYHVFATVRTPSKAPK
                     SLINSPNATVLTLDVLDSTSISDAVEKVTKATGGKLDVLVNNSGGSIILPALDTSIEDG
                     KKLFDLNFWAPLAVTQAFAPLLIRSKGCLVNNTSVNGALPFVFMSMYNSSKAAFMSASE
                     TWRMELAPLGVRTITLMTGGVKTKFFDNYVPRQVPENSYYIGAKDAVQKMGDGSLQDSG
                     IDRYSYASKVFQAVERKVSGKLWVGGGAVPAKWALWLLPQWGVDLMMRKMFPVFGTIEA
                     GVKKDA"
     mRNA            join(<18907..19117,19183..19615,19673..>20375)
                     /locus_tag="M747DRAFT_323939"
                     /product="hypothetical protein"
     gene            <18907..>20375
                     /locus_tag="M747DRAFT_323939"
     CDS             join(<18907..19117,19183..19615,19673..>20375)
                     /codon_start=1
                     /locus_tag="M747DRAFT_323939"
                     /note="EggNog:ENOG41"
                     /product="hypothetical protein"
                     /protein_id="ncbi_M747DRAFT_323939-T1"
                     /transl_table=1
                     /translation="MQGINKGRPRYDRRKKPSPIQQDQLPSPQLTKMYQDSDIIQSNKL
                     VVGPDPSFAQFAVQVDSRTFADILRFAKLSMQMFFPLGFLIDFDCRDKSWFHDSIRSDA
                     AYLHLTVSASEVFMGSVHGRQNADELLANRRTMLHFAKGVQILRERLTGVDLQTKISDF
                     TVRTVLMLAMTAHLMGESEVAQKHMEGIRTIMDLRGGLRLFESQKILIELFRWDLGLAL
                     QNNTTPMFFRDKFLEPLTPFPTIFNPTLNQINNPILPQLHLDPTLKTTFHVLQNFCTLI
                     NTSITETPQRRLSPDIIPSTLSSVMYRLLQMPFPMNSNNEAFRLGLLTFCHHTFLQWQD
                     KTLPFVYFPASYQSCLLSLMEQCQRRQDEEEDSSELILWLLMVGILALPPLPSFLGTDL
                     WMRGYLRESLEKLEIRTWGELRGIMKRWVWVDLMHDLAGEGVLGDVLKV"
     mRNA            complement(join(20631..21313,21374..21682,21744..23175,
                     23290..23321,23435..23674))
                     /gene="HSP88"
                     /locus_tag="M747DRAFT_296703"
                     /product="Heat shock protein hsp88"
     gene            complement(20631..23674)
                     /gene="HSP88"
                     /locus_tag="M747DRAFT_296703"
     CDS             complement(join(21023..21313,21374..21682,21744..23175,
                     23290..23321,23435..23509))
                     /codon_start=1
                     /db_xref="InterPro:IPR013126"
                     /db_xref="InterPro:IPR018181"
                     /db_xref="InterPro:IPR029047"
                     /db_xref="InterPro:IPR029048"
                     /db_xref="PFAM:PF00012"
                     /db_xref="PFAM:PF06723"
                     /gene="HSP88"
                     /locus_tag="M747DRAFT_296703"
                     /note="BUSCO:EOG092616YZ"
                     /product="Heat shock protein hsp88"
                     /protein_id="ncbi_M747DRAFT_296703-T1"
                     /transl_table=1
                     /translation="MSVVGIDFGAQSTKVGVARNKGIDIITNEVSNRSTPSLVGFNARC
                     RALGEAAKTQETSNLKNTVGNLKRLIGRTFSDPDVAIEQEYTTAQLCDVNGQAGAEVSY
                     LGKKEKFSATQLVAMYLTKIRDITSKELKLPVSDVTISVPAWFTDVQRRAMLDAGEIAG
                     LKVLRLINDTTATALGYGITKVDLPGPEEKPRRVMFVDIGYSDYTASIVEFRKGELNVK
                     ATAYDRHFGGRNFDRALTEHFADEFKEKFKIDVRSHPKAWSRTLAAAEKMKKVLSANPA
                     APMSIESLMEDVDVRAIVKREELETMVKPLLDRVTVPIEEALAEAKLKPEDIDFVEMVG
                     GCTRVPAIKDAVAKFFGKTLSFTLNQDEAIARGCAFSCAILSPVFRVRDFSVHDIVNYP
                     IEFTWEQSADIPDEDTSLTVFNRGNVMPSTKILTFYRKQPFDLEARYAKPEMLPGKVNP
                     WVGRFSVKGVKADANDDFMICKLKARLNLHGILNLESGYYVEDMEVEEPVPEEGDAMDT
                     DGKDGEQPKKTRKVKKQVRKGDLPISTGTTSTDESVLNAWTERENSMYMEDKLIAETDE
                     KKNELESSIYELRDKIDGVYSEFANEEEKDKLRAKLTDTEDWLYEEGEDTTKSVYVAKM
                     DEIRFVAGPIIQRYREKQEAERQAQEEAANKKRAEEEAKRKAEEEAKKAEEEAKKAEEK
                     PDAEMKDAPAEGEKPAEQ"
ORIGIN
        1 tctcatgcgc cgctccaagg ctattgagct gaaccagccc attctggcca agttctgcgg
       61 tgccaccgtc gcgggagtgc cgccccggat catgggtatt ggtcccacgg cagcgatccc
      121 caagctgctg tcccagttca acttgaacaa ggacgacatt gacatctacg agattaacga
      181 ggccttcgcc tccatggctg tctactgcct taacaacctt ggtctggagc acgccaaggt
      241 gaacccgcgc ggtggtgcca ttgcccttgg ccaccctctg ggcgcaacgg gcgcacgcca
      301 gatctgcacg attctcagtg aggcgcgccg gacgaagaag aagatcctgg tgacaagtat
      361 gtgcattggc acgggccagg gtatggcggg tttgtttgtg aatgagcagg tgtaaaagta
      421 gatagtatgg tatcatatca tatcatttca tgtcattaaa tgctggtgtc agcaatggag
      481 tggatactat gatgctacgc gaatccagaa actatacaca agccactcaa ccaaaactaa
      541 caagatccat catggtatat cacgacttgc cctccccttc tctctctctc gccctcttca
      601 tcctctcctc cgccgccttc gccaaaacct ccctccgact ctctcctctc ccatcaccac
      661 cacccccacc cccaagcaca aactgccccc cagtccatcc cttctcatca accaccaaac
      721 cctgctccct aaccccctcc caatcccccg gattataaaa ctcctgatcc cccaccgtcc
      781 tcccactctt cgtccaatcc cccctctcaa cctccttctc aatctgggac gtcaaatccc
      841 agaaatcacg atcatgttca ctaaacacac aatgcgccag ctcatgacac agcgtcttcc
      901 gtatcgtgcg ataatcccta tacccatcat acgcatccgt cctcagcctt aactcaatca
      961 cctcgccctt attccgattc agacccaatg ttctcgactc gctcgtcgta tgctcagccg
     1021 gatccatctc cgttaacagc ggcacagaga acttatgttt ctgcatcgcg gatttaatcc
     1081 cggggtcgtc gcggaggcgt tcaagaaacg tcaatgattt agaagggtta gggagatgcg
     1141 ggagcggaac gcatcggtgg aaagtgtagg agccgctgcc gttggcgctg ttggcgaggg
     1201 tgtggatttt gctgatgttg gaggaggtgc tggacggggt gggtttcgcg gcgtagagac
     1261 ggtgtgcgcg atcgcgggct tcagcgcggg ctttgagttc tgtgccgtgc gtgttgaggg
     1321 actcgatgtc gcgcgggggt gtgcccagca gggtgagttt gaatttgggg gaggtgaggg
     1381 ggaggaggtc ctggaggggc gttggtggga atggatgttt gagcatgccg ggggagggag
     1441 atatgaggag cttttggtgg gttgggggga tttggagtgt cgaggagatt agctctgtta
     1501 ggtctgtgag ggtgctggtg gttgggaggg tgagggagtg ggaggcgttg cggtggtgga
     1561 tttggagggt tagggtgccc cccgttgggg attcggtgtc ggtcatggtt gggggatgga
     1621 tgtgtgtggc gcgtgaaatg ggggagtatt gtgggggaga aagttggatt atatacaaag
     1681 acgcagaagt ggtgatgatc ttcgatggag ttcgatcttg ttttgtcagc gataaggcga
     1741 taagcatggt tttatcacgt ggtgataggt gataagagct agtcgattaa ggttagtgtg
     1801 gtttcacctt tttttactgg tatgtaatgg aagggcccct ggttactggt gcctcaggta
     1861 gcgagcggat cgtcgctgct taatttcggc tggtccgagg ctgtttggcg ttgagagatg
     1921 ctgtctggga ttgatcaccc cgcgggtcct actctgttac aagtgtacta cgcctgattt
     1981 agcttgtgca gaatgatgca gaaagattgt atgaccacta gattgactct gcagaacgct
     2041 gactgtccac aacgccgcct gtaccctgaa ctccgatcct tatatgatta tttaccaaaa
     2101 atgaccatga caccatccaa tgatgcactt atgacagtcg atagcgagaa tatgcagccg
     2161 gtatgactgg ctcactcata ctgccggtcg tccattgcgg ccggcacatc cagcacccac
     2221 tcttcgagtt ccgcatccca cgtatgacta tcacatgtca gcataaggcg gctctcggct
     2281 agagggggat ttactcactt gtgaaattgc gtgttcgtca acgccttctt tgtatactct
     2341 tctgttagca ccccatcgta cctaaatggc accttggctg gcacgccctc aaacgtcgat
     2401 ctccgcagtg gatagatatc gtgtgtctga tatttgtgcc cattcttgca ctcccattct
     2461 gtgggctttt cggccgtcag tcggcttagc cctgtgatat cgatgtatag ccccgtgctg
     2521 atgtcgatcc agcgcgcatc aattatattc agtcccatgc cgcgatcacg ctgacgcgcc
     2581 cacgggttta tatcgaggag gtaccggcgc tcgacgtcgg ggtcggtagt ggtatactgg
     2641 acaacggtct gattgaagtg gtcggcgaga tggaatagtg tggtatccat gacttgagtg
     2701 tcgatgtccc agtcccaagg catgatctgg aaagaagaag ggttaaaaca gccaaaacta
     2761 accatgtctg gtgcatcagg aatagctcac cttgccattc caccaccacc ccagcaatgt
     2821 cccatgcgca atccatgttt ccaatccatt gtcctcaaag aagttcagat atgctcggat
     2881 catatgcgtc aatgtgatag atcgctccgc gtccggaacc ggctccccct ggaaaaatcg
     2941 cgagtcatag tggcccaggg tgtcgtcacg acctggctca tggaaatact tgaactcgtc
     3001 tgacttgttc agcccgtact tctgccacag cgggtctggg tcattgcggt tgacgaaact
     3061 gccgtggttg ctgtgctctg cggggctggg gcgtgctgtg gccactgctg accagatcgc
     3121 gcaggtgagg acggccagca ggccccgagg gttcatgtcc ggcggcagat gtcaacgttg
     3181 tgtgtttgaa aagggttttt atttttgaca gttcgggagg tcaatcatgc ccctgcttgc
     3241 attctggacc gggtaggtga tgtttgggtg agtatgaaaa gttgatccgg ttgatgcggg
     3301 ggatcagaac agggctgcca agtcgttgct cgaatgcgtt atagccgcat acgtcgaaac
     3361 atataattcg cgtggtgcat cggacgagag aaaagaaggc caccggtgct aacaatgaga
     3421 gcagccaagt aagtgccagc ccgactcgac acgccaatca ggcatggaca agacaggggg
     3481 gaaagataga ctgagggggg gaaagataca aggaaaagga aaggaagatc aggagagaaa
     3541 agcacgggga acggttcttg atagtccgac tagacaggct tcgagaacca cacgagcccg
     3601 caaatcaaac cggaagatcc gacgaatccg ttcagttaac acaggacggg aaaaagcttt
     3661 gcacctctgg gggcgaggga aaattggtta aggccgagga agaatagaat caaatacgac
     3721 tccgtattaa cggggtgact tcaacaacca gccaagcggg gcgacatttg ggaggcccac
     3781 tgaggaccct cattagatag attattacat tggcacaagt tgggaatagg ccttggaccc
     3841 tttccgtgga tgacgctctg caggtccaga tcggcaagga taacagccat gacgacaggg
     3901 agctggttgg ctgcgcgaag cacgccggca tgccaatgct ccattcccat gaggacaaag
     3961 agagctactt gttatacttt tgtaggagag tgtcaggatg gatggtcttc tcttcggaat
     4021 cacgagagta atagttccta ggcaaccatc aaagaatcca cccaaaggag acggcgctcc
     4081 ataattgatt gattgatttt ggccgaattc agggaagaaa gaggaaaaga gtcgggcctc
     4141 gcgtgccatc tttcccgacg tgtctttggc tctctttttt ttgtttccca ctccctcccc
     4201 acttatcttc cctcctaggg atgtttgtta ctactgctta catacgggaa cgccttccgt
     4261 accatccgct taccgtaaca ccaaccagct tcagcaaagc agccaactga ttcatagggc
     4321 tacacaccca ccccccttgg tcttccctgg tcgcaatgtc catgactcca ttgtgtctag
     4381 tagtcagcac agcacagatg caggatggct ttggctaatt atccgtgcca cggtgacacc
     4441 atcctgaaaa tctccccatt gtattttagt gtccgtgtcc ctcccttccc tgcaagcagg
     4501 acaatttgga ggcgccgaac ggctggttct cagacgatga cctgcagtgt tgaaactccc
     4561 ctaaagcaca agggggcagt gtgttggcac gaatcatata tgagattccg ctcctgctat
     4621 gaggccaaga attaaaagga tgctgaggcc aagagacgta ttaataatgt ccagcgagat
     4681 cgatacatca tgcacctcgt agggcagaca aatgccctac agtacgccct gcattatcga
     4741 ccaacaacta ctggatacac accatcgagc gctaacgatc cttgcacctg actcgagtca
     4801 agcaagtcct tctatataca tacgcacgag catagtacct acctccaact tccacctgct
     4861 atccgccccc aaattaaatc ccccataaaa gatgaaaaga gtactagact ccgctaccga
     4921 gtatattgtc agaatcttat cgcgcatctg aaacagtccg gttgcttcca gggagataca
     4981 aaagtagtcg tctaggtggt cgtagtagtt acataccacc atcgtacgac atccatacac
     5041 ccacccctaa ctcccaatac cgtaacgaac tgccccttat tcggaagaac caaggttgct
     5101 ttccaaccat caggttaggt taacccccct ggactttcct gactagtcgt cgtccccaca
     5161 gaaatgctac tttagtcttg atggctgaac ccaagcagaa ccaattcgct cacttctctc
     5221 cgacgcatct gcgcggaagg gaacaggacc ctgccaatct cggagctatc aaatgcctcc
     5281 gtgcaggtat tggttgttgc ctatcaaagt acaggggcag gaggagagcc gagttttcaa
     5341 ctacggagta ctttttaata taccgaccta tcaggtggct agctaaattt tggtgctgag
     5401 acctgtttat aagaaatatg ccaaggagta tcgaatagtc ggacaggtct gtctgccaag
     5461 gggtgggagt aattggtggc atccggtgat tccgctcgta ctcgtttttg tatggattgt
     5521 tttgggggga tcagaccttc atgccgggtc acttgactag tctgttttcg ggtctgccaa
     5581 gcctactgcc gggtcacatg atgatgctca gggtcttgga tttcttggtt cggtattttc
     5641 ataacatttt ccgcttacta atacgttatg tccattcata actgcatagt ccaactatgt
     5701 gctaaccggg catatacaac ttccacagtt catgcttctc ccatcacctg ctgtaacctg
     5761 gccatctgcc agtattcgcc ctcgagttgc atcaactcct tgtgggtccc tctttctaca
     5821 atatgtccat gcttgaatac caagatttca tcagcatcga caattgtctt cagtcgatgg
     5881 gcaacagcga tgaccgttcg ccccttcatc acacgttgaa gtgtcctctg aactagttcc
     5941 tctgaggcgg agtctagtgc tgaagttgct tcatcaagca gactgacagg agttaggatc
     6001 cactaatcac ggattttcta tgaaggggcc ccttacagaa tctttggccg acatagaagc
     6061 gccttcgcga tggccatgcg ctggcgctgg cccccggaca gggtcgatcc gttggccatg
     6121 actggagtgc ttaagccttg agggagtgat agctgacaaa ttatcaagat agtcaggata
     6181 tgtaacaagg atatttgagg ggttgaaggc ccgtaccaca taatcggcta acccaacgtc
     6241 ctccaaagcg gccaagatct catcgtctaa tacaaccagc tcaccactct gcaggcaatc
     6301 gctcagagtt tctccgatta gacaaggatt ttggtcgacc agcgctagat accctcggta
     6361 actgtcgagg ttatattgtt caatgggcat atcatctagt gctattgcgc cagtttcacc
     6421 ggtgtagaag cgctccagca gatttatgac cgaactcttt ccgctgcctg tagcacccac
     6481 gagagcaatg aaggcacccg ctggagcgtt cagactcaca tctttcaatg ctaattgaga
     6541 cgaatggctt ggatatctga agttgacgcg tcgtagcgaa cgttagcggt aatacttggc
     6601 acgtcagcgt cgccattatt gagctttctg tgggtggctg ctgatattcc ggcgcgcatc
     6661 agctcctcca gtctagcacc agcagcttga gaacctgcaa tgtcaggagc atgtgcgaaa
     6721 agcacggacg cagactgaga tccccacatc gtggctgcga agcagatgaa gaactgctgg
     6781 acattgtatt cgccagttgc gattaggtgt gtgccgccgt accagaaaac gaaagcgatg
     6841 ctcaacgccc ggagggaggt agtgcactca tatgtcgcag caaacatcag ccagtatttg
     6901 cgttggctgt ctcgatggct tgcactttcg aacgatgcac tgatggcctt ctgcagacca
     6961 agaaccgtca cagtcttgat ggcagaaagg gcttcatgtg caatagccac agcactagtg
     7021 tcacgcttga tgtattcctg tactcgcgcc acagtgtggt attgcataaa gccggaaaca
     7081 actactaatg ggaccgttgc tgtcgcagca agaccaagct tccacccaaa gatacacccg
     7141 atggtaattc ctgtcgcgag catcacaatg ctttcagcca caagccccag tgatgttccc
     7201 gaaacaccag tgatttgccg aggcccagat gcaaggaagc tgaccaatgc accaatcgaa
     7261 ttgtccttgt cttggaagaa ggggagatcg ttcacaagca gatgtttgaa caactgcgag
     7321 cgggctcgga gaaccaactg tgatgcggac acggcaaagc aatatccccg taccgaataa
     7381 acgacaaatg cgataatacc gagggtaagg tacatggtgg cccagaattc aacattatgt
     7441 ccaccggtac tgaggctagg attaatcatt gacatgatcc cgttaccaaa gaagattgct
     7501 tgaacaggat atgttattcc agccagaacg ctgaagctca cgccagcggc tatgtaagga
     7561 aactctggtc tattgagact ccaaacacgc ccgacactgc tactggacga ccgtactgct
     7621 aataggccgt cctctggtat gtccaccgta tcaaatttga ccaggatatc tttggaatgt
     7681 tcttcatgag tgctcaacga gtgcggccgt tgtctgataa gcctgtctcc ctctgatcga
     7741 tggaatgctt caagtgcctg atgcctcact aattctcgat acatcgcaga tgtactcaac
     7801 aactccgcat gggagccttg gcctaggatc tgattgtcct tcatgacgat gatcttgtca
     7861 gcattctgga ctgtcgacag ccggtgggct attatcaagg tagttcgtcc tttgacgact
     7921 ttgtccagcg cctcctgaac tgctttttca caccgactgt caagtgcagc cgtggcctca
     7981 tccagcagta atatagctgg ttgagagatg attgcacggg caatggcaag acgctgcttc
     8041 tgaccccctg agagatttga tccatgtgcc tcaatcatgg tgttgtactc cttgggcata
     8101 ctcgcaacga aatcgtgaat ttgggcaact ttggcagcct cgattacgag ctttcgtatc
     8161 tcgtatgcgt cctttttcta cctcacaaaa tcagtatcag aactggaagg caaaagatag
     8221 tggtcgtgaa gcacctcagc ggcagctttg ggaagcccat atgcgatatt atcgtgtatt
     8281 gatgcacgaa acagggtgac gtcctgaccg acatacccaa tctgcgacct tagccacgcg
     8341 acgttcatgg catcaatcgg ctcgccatcc agcatgatcc gaccactgtg tggatggtac
     8401 agtcgttcta aaagggcaaa cacggttgat ttcccagacc cagatggtcc aacaaacgct
     8461 acagtgtgtc cagcaggtac aacaaaatcg acacctttca aaaccttccc ttcaggccgc
     8521 gaaggatacg taaagtgtat atcttcgaag ctaatatctc ctctgacccg actatgcgtc
     8581 accccggtac ttgcagaagg atctatcggt gattcccgct caatgaccga aaagacacgg
     8641 ctgacagccg cgttggcctg ggtgatattg acaatggatg gcaatgcttg gcttagcatt
     8701 ccacccgcaa cggccattgc atacagaatt gtcaagactt ccgaaatagt gcaatgccct
     8761 tggcggagga gatggtcagc ctgccagaac ttggcaatca ttagcgtggc tggagcaaga
     8821 aactggaagg ggactaacta tatacatacg cccaacccgt tcgcccagtg cataaccatg
     8881 acagaccctg caacaagcat accgaagatg aagcgctccc gaaagtccaa ttctgctgga
     8941 tgtcgcaacg cttcgtaata ccttttgcca tacctttcct ggcttcgaga agcaatgacg
     9001 cttctcatgg cgctgagcac ttcctgggcc aaattgtctg ctctgacgta ctgagctaga
     9061 ctccttcgct gtgttaaact taaaaatccc cccatcacgc cgatgagtgt aagcagggca
     9121 atcggttgag agatcatgat gcctgcaaag cgcccattct ggatgaacgc gcagataatt
     9181 gcaacaacaa agccagacaa cccagaaaga agctcaccaa ctttttgcga gataccagct
     9241 tggataagct tcatatcctg atccatatga gacgtcaact cgccaatacc gaccacatcg
     9301 aaataagcca tattctgccg caaggctgaa gcgaggtatt tctgctgaag ctggcgcgag
     9361 atttgctctc cgatggtgtt gaagccaaat gtgctgatgg cagtcgtgat cagagacccg
     9421 attgctgcgc tgctgcgtca gatggtgaca gataacggat taatccagat ctgcctaccg
     9481 atatacacca agtagagcgc gagactctga acatggtgtc gaatttcgtc cggtgcattg
     9541 ttatctccgg tgatgaactc gcgtgcaaag tttccataca cgactgtcac tagaggcatt
     9601 gctgcgcccg cgactattgc gcagcatcct gatagaaaca gcagacatag ctgcgatgtg
     9661 ttggcggttc ggtaaatggt aaagatattg gcagtgctgc gcactatatg aatttgggac
     9721 tggagggcct ctgccttatg cgttgtgtcg gcagttggct ggataacctt gagtgggatt
     9781 ccctggctgg acatgctcat gagtagctta atcccaaagt gctgaactaa ggctaaatgc
     9841 tccgggcgac cggcttattt ataaggacta agatgtgatc gactaaaatg gattggacta
     9901 aaatgcgatt gctacgtggg tcacggcatt gacatggttc tttccaaatc cagaacccct
     9961 ggtctcaagt ttaacgtata gctaatccgc ttaacataca tcatttctgc tcatccagct
    10021 ccagcaatgc taccaactgt ctatggattg ctgcccacgc cccaggtcgg gttttgaaca
    10081 gaagccaata atcccccgca gcatccttcc cgataatcct gactacgttc cgggtcggat
    10141 aaccctgaca agtctcaatg tcgttgatat acgacggtct acctagagca tgtggtcgtt
    10201 cgctcagagg tactcctgga gccaccacgg cggccgagaa gtccagttca aaatatctgg
    10261 ccttgtgttg attggtgcat gccatgaaca gcaaattggc atctccgaca actggtggtg
    10321 tccgagtgaa cgatgccctc tgcatggagg tcaaggcttg aacctgttcc tttgtccggt
    10381 gctccatgag ggctttacgg ttcttggacg ccacatacgc gaggctagca tcctggataa
    10441 cctggcttgc aaccagcagt gtgtaggagt agaaaaaggc gtttccaatg aaccccgctc
    10501 cgccactcgg aaaccattct tcaaaaagtg cccatacgtt gaagacgttc atgaccatga
    10561 tggttcgatt tggcgcagga ttcagagctg tggtgatggt cctcacccac cacgccatta
    10621 caacatcgcc ttcactcagg aagggtgcct ttgcctcatt atccggactc attgcagcaa
    10681 gctcctttcg agcagattcc ttcagctgtt ccacgcatcg tcttggcagg cgaataggat
    10741 gttcctcctc tttctggtac cacagtagct cccacagata ccgcagccca aatatcacta
    10801 ggctaagtcc gctaagagcg cggccaaaat tactatacgg cttcaccggg gcttctgtac
    10861 ccagtgtgcg cagaggatca tgttcaaaag ggatgaaagg tggtacttcg tcttctcgac
    10921 cccgcagaac agctatccac gccttgaaga aggttgtccg cgcaatagca tcaaaaagcg
    10981 tatgaacata gctgaccgtc acgagagttg cgtcttgaaa gacagaaaca tggatatgaa
    11041 gttgtggccg atcagtgtaa atccaatcag ccaatttacg aggactatcc ggatggcgga
    11101 caataggagc gaagacagcg ggcgaaggcg aaagaaccga ttgatcttgg cctgcttttg
    11161 gtagctgctt accgagtgcg tgctcggaga tgcgcaaccc atactcattg gtggtgaagt
    11221 tgtatgcagg ccgcgccttg gtatactcag caggaatgtg gtattcgagg cgattttgat
    11281 cctggtttgg agagagcgtt agccttgttg ataccagcag gaattgatat gagaatggag
    11341 gaatcttcat attcatacgt tcaggcgcag acgagctccc aactggcccc agtttccaat
    11401 ctctgtcaaa cgtgccagag cagcatcgag tttggaggcg tccagtacgt cgtcaaagcg
    11461 aaaggtgaaa tcatggcaga gacgacggag gtagtctagg tcatcccaat accgtagggg
    11521 gacaaccttg tcagtgggca cagttgctgg ccgggcacgg ttgaagatcg ggaaaaaatc
    11581 catcattttg ttgggctatc gtgcaaggcg tgggccaaac aagaaaggag gagcggaatg
    11641 cagagaaatt caggcatgcc acggctctct ggttttctgc acaagctgtc atcttcatct
    11701 ccatctgcat cataaagtca cacgaatgcc aaccgggaag aggggggggt tcaagcaggg
    11761 aaggagctgc tcagagtccc acaagaggga aagcaatcac tgcgccccgc cacgttccca
    11821 ataatgcaat cgatctatct tgatccactt gaaggaaggg gaatgtgacg aaaggcaact
    11881 tcatacaaca cgatcatgca gttcagccgc acgccccgcc cgccccgaag aacgatattc
    11941 cctttccccc tcgacatact ggcacgcccg ctgaagagcc cgtcccaatc tacgatgtct
    12001 cacagcatac cttcagaaga accaatgatt ctcaagaagt acctcacgat ccttttgggt
    12061 acattcttcg cagtcccact agatactacc tgaccacacg gagaaggaaa tgtttttccg
    12121 cccttcagcc ctgctagttc aaaatgctag ctcatactac ggagcaccta ccaaatccat
    12181 ccaaatgaac agacccattg tgatcccaac aaaggaagcg gggtctgcat acggagtaca
    12241 ctatccatat ccactagtcc atctagaccg actctcaagt cccgatccaa tccaatatat
    12301 ccgacaaaca aacagtatgc acgctacgtg tctcgtgctt gttcactcga attccttgtt
    12361 gtcgtcaatt catgtgctaa tgagtatccc gggactactc tctggccgct ttgaccaagt
    12421 aaggatccac atacggagta tctactagtg atatctagct gcattatgca gttgtgctcg
    12481 gctaattgaa taaattaaaa tggtggcgat ggctaggaat tcactcgctt tcatgagtgt
    12541 ctcatgcatg atctgatagt ttttgtcaca atacgtgagc atcagctctc tccgattttt
    12601 ggtggttata cagcatggta atgctgccgc gtttcttcat gtttacgcat aatgaggcgt
    12661 tgataagttt attcttgaag aatggtacgg ttgtaaagtt aatcttgggt tggcacacgt
    12721 gtcagcagta ctgaaaaaag aaagttccta caattttaag gttgtgttgc tactatgctg
    12781 caaggacgta ccaggaacta gtcgaagcta aaaagtacta caggtgaaaa cactcagata
    12841 gtcctggtaa atactaaaaa atatgatata tatactagtt gcggtgactg cctcacaatc
    12901 tctgtctaca tagttatcca agttattgtt caaaggcgca gacgcatgtg atcgatcggt
    12961 tggctgcgaa acacctcctt gcggcatctt caagcctggg cttgactcgc ctgcaaatag
    13021 cgcccaagag ccatcatggg aaagtaatgc cgataatagt cgtagcccaa atagaaatga
    13081 ttgggaaatc ctgttcccgt gtagaccgct tcgggccagg aagctccatt gcccttttcc
    13141 ggctgctgtg agcataccag ccaccgaatc ccccgctcaa tcgcagggtc agtgagggga
    13201 aggtgggcca atagtcccat tagcgcccat gcagtctgtg atggcgttga ttgctgctgc
    13261 agctgagtgc ccggtgttcg gtacgatagt agcggttcgc cccaaccgcc gtcgtcattt
    13321 tgcttggatt ttagccactg tagcgccggc gccaccagcc cactgactcg cttgtcgtct
    13381 tccatgtaat atgccaatcc gcacagcgca tgacacgtcc catagatgta attacatccc
    13441 catcgtccga accaggctcc gttggactct tgtgtggatg caaggtatgt gatcccccga
    13501 atgcatgcat gccgtagcat tggagaaagg acgggtcttt tcagttcacg cttcatcatt
    13561 aaaccgaagg cttccagaat ccgcccagta atatcggcac aggaggtgtc acataagctg
    13621 tccatatcac tgaagggaat tttgttgagg aacagcttat cattttccac gtcaaaggcg
    13681 gcccagcctc catcggggtt ctgcatgcct aggatccatg ttgctgctgc aatcaccgag
    13741 tccgaagcga cggactgggg atcctgctta agctgagcca gaatgatggc cgcggtgtcg
    13801 tccacatcgg gatagtggct attctcgtac tcaaagctaa accctccagg ggctagctta
    13861 gagcggtaga tgcgccagtc cccgcagggc ttcagcaatt ggcgattccg gatccaagtg
    13921 atggcctgct ggaggatctg cttatcgggc gacatggcat cgcaaagccc gatcgacatc
    13981 aaagctgtgt cccacacggg agacacacat gcttggattc gtttgccctt ctcgtcttcc
    14041 caagcaaagt tttccaatgc ttggattcca aggcggactg gagggtcatt tagctcgtag
    14101 ccctccagca cgaacgcata aatactggca tgcattggag gaaagatccc agcccagtca
    14161 ccagtaggtt cctggcgctc gaggatccac tgtatgcatt ttcgtcgagc gtatgatcgg
    14221 agcaaaggga cggaacgcag accgttcaga tagtagagca agttatccac gacactaaat
    14281 gcaagtccag taatgtctcc ccgagacagc agatcccgga gtgacgagcc atacggcaca
    14341 tttttgtccg tcggatcgag ccataactca tctaggtagt cctccggtag cgcgtacacg
    14401 ggctgatggt ggcagataat cagcagcggg gcaatcgttc ctcgggccca ggacgctaaa
    14461 gtgtacatgt tgattggaca actggaaggc aaaagaatta gctccacggg tagctggggc
    14521 actgcatccc atggaaataa gccgaaggtt gccaggaata tgcgagtgaa aacgcgaact
    14581 ttttcagcac cgcctgcttt gcgaacaaat gcacgagctt gttgcatggc cggcatgtct
    14641 ggactcgtcc ccagcaactt gagtgctaag taggcttcag tcgtggtgga tacgtcacct
    14701 ggatactcag gtgctaggcc ccatgaacca tcgcagttct gctgtgatag tatatagcgg
    14761 cagtaagccg cattgtcggt cctcaaatcc aggcctaaag cgtgtcgaag gaagatatac
    14821 tcggccgtga tagtaacatt ggaccttaac tccccgcacc aatgcccatc agagcgtatc
    14881 gaactgagag catattcggt tgcaagcttc agactatgct ctatatctga agtaagttgc
    14941 tctttcccgg gggttatgcc ttctttgtgg ccctcttctc tcaaagtcat catcacaaag
    15001 ccggcgtggg tttcgagagt ggaaagtagc aaagtagcaa ttataaagtt gtagtagagg
    15061 taacagcaaa caactgcctc tcggacaaca ggaagagatg ttctatatcg attctccagc
    15121 tctgtagtaa ggagaaacta tgcaaattta tagtagtcga gcatgtttag cgtattctag
    15181 tagcatggat attggtgggt cgcatgtgag ggcgcggggt ctctctttcc ttccttgatt
    15241 cccctgttaa tcactctcgt caaggattcc aggtctgctt acctgcaatc tcttttcact
    15301 cgatagacca gtcatccgag catgactgac tgttacccag cgtaaccgtt ccccgtcagc
    15361 atatggcctc tgctttgtcc ttgctttgtc accatgcagg atgtccaaag gtacaattca
    15421 aacatgacag cactgctgct atccggaccc tccaggccaa acggccttct cctagctttg
    15481 gctgtaattg ccgttggtgt cgcgatcacc ctcttggcaa ataatttcaa ccagcgccga
    15541 agatcgcgac aacttgagcg acttcatggc tgtgagcagc cgcccaacga aagcgaccgc
    15601 ttccaatatg acatttttgg catcgctaaa tcaatcgagt tggcatatca tttccgccgt
    15661 cgaacgtctc tcccgtacac aaatgcactc ttcgagagat atggggagac atatgcctcc
    15721 aatgtcttag ggtatcggct gctatttacc tgcaacgcgg acaatatcaa acatctgctt
    15781 tcagcggcat ttgttgactt cgatagttct ccgttgcgaa ggccattgtt tgagccaatc
    15841 acaccacatg gcatattcac ccttgacggt gcggcctgga aaacaagccg ggaacagttg
    15901 cgaagtcggc tctccgacct tcgcaaggcc atcgatctta gcttgtgtga gcagcacttc
    15961 caagcttttc ttcggcacat ccctctgaat gggcgaccct tcgatatcca gtcctgcgcg
    16021 tttggtctgt ctctagacat gcagaccttg ttttccctgg gagagtctat tgatgctctc
    16081 agctccaccc aatcccaaga aaagaagcaa tttttcaagg atctgcttct tgttaagaat
    16141 agaatcgtgc aagatggctt ccgtggcccg cttcgtcatt tagtacccaa acggagcttc
    16201 ctgcaggctt gcaagagctc acgagcatat gtgatgactc gggttgttag agatctggaa
    16261 agacaaggca gtgtggacaa agaggcggat gaactgccta cactcgaatc atactccgat
    16321 acaaatcggg tatcacagct taccgatcaa gctttgagta tcttacttgc aaacgatagc
    16381 atgagcacga cactttcggg ccttttctac tgtcttgccc agaacgagcg cgttgtgcat
    16441 aagctgcaag catccatcat tgacgccatt ggattgacac ctccaacgtg ggggcaactc
    16501 gggacgctgc aatatgtccg ctgggtcctt caagaaggtt cgaaacctct tttggccatc
    16561 tcagttaggt catgcactaa tatcattgtc cagcgatgcg actatttccc ccagttgttt
    16621 tgaatgcgag agtggcaaac aaggaatcaa ccctgccaac tggaggtgga gctcatggtg
    16681 ataagccggt tcttgttatg aaaggagaca ttgtagtttt ttccacctgg gctaggcatc
    16741 gcttagggaa ggattttggg gaggatcctg aggaattccg tccagagcgg tgggaacagc
    16801 taagcggaga catggctggc tatatcccgt tcaataaggg tcctagaatc tgccctggcc
    16861 gtaagcttcc gttcatttac ggtgatgcgc aagatgcact ggctaacaaa agagcagaac
    16921 attatgctat gactgtgctc acatacattg tggctcgcat attccaaacc ttctcaaccg
    16981 tgtcagatta taatgctagg ccatggacgg aacgcattag tatgactttc gagaatgaga
    17041 atggggtgct agttgggctt agctaggcct tcccatagat gtgtagactt tcttggataa
    17101 taatcgtctg gctgatgagc gaagagatac tggatgagtg ctggttcatg cagtgatgag
    17161 tttggccaaa agacatgaaa gctggtgaga agcaatggtt tagtgtatgc aaacaaggaa
    17221 ggacaccaga gctcatcagg tgactataat tgtataggcc aaaagcgact actatattaa
    17281 tgataccaaa tcctggggga aaaagcatta tcattactct gagaataacg gcacggcgac
    17341 tgcgtaaccc cagctacgca gccatgacgg ttgcgcagct agtatacgac tttaagcgtc
    17401 tttcttcacc ccagcttcga ttgttccaaa cacaggaaac atttttctca tcatcaaatc
    17461 ctaccaaagc atttagtaca tcatcttcat caatgccaca taggtactct gcagcaaaaa
    17521 ggagaaggat acctaccaca ccccattgcg gcaataacca cagtgcccat ttcgcaggaa
    17581 cagcgcctcc accaacccac agctttcctg acaccttcct ctcgactgcc tgaaacactt
    17641 tagaggcata tgagtacctg tcgatgccgc tatcctgcaa gctcccatct cccattttct
    17701 gaacagcatc ctttgctcca atgtaatatg agttctcggg gacctggcga gggacgtaat
    17761 tgtcaaagaa cttagtcttc acaccaccag tcataagagt gatggtccga acacccagcg
    17821 gagccagctc catacgccaa gtctcgctgg cgctcataaa ggccgctttt gaggaattgt
    17881 acatgcctta agtgagatat actagttaga gaatgccagg ctctgtgact gtatttggag
    17941 agggactgga ctcactcatg aatacaaatg gtagagctcc attcactgat gtattgttta
    18001 caagacaacc tttggacctg atcagtagag gagcaaaggc ctgcgtcaca gctaagggcg
    18061 cccagaaatt caagtcgaat aactttttgc cgtcctcgat tgaagtatcc aaagcgggga
    18121 gaataatgct gcctccacta ttgtttacta gaacgtcaag cttgccgcca gtggctttcg
    18181 tcaccttttc cacggcatca gagatagacg tcgagtccag cacatccagg gtgaggacgg
    18241 tggcattggg agagttgatg agagacttgg gggcctttga tggcgtgcgc acagtggcaa
    18301 agacatgata gcggtgatcg tggaaggtct cagccagtgc agctccgatg cctccatcgg
    18361 agcagcccgt gatgaggacg gtctttcgat ctgtggacat ggtgcgaatt gcaaaagagt
    18421 aagagtatgt caggaatttc tggtaattgg agagagaaag aaactcacca tgggagacat
    18481 cttgagaaga tatttatctt gcttccagct tcccaagaag gaaaatagta ttgtagatat
    18541 ggtgtcgccg aatgaatcca gcaggaagta taccaaggcc ggtgactata ccggaatcgg
    18601 caaatgatat tagaagcagc gacacgccat cggttcctgt cagcatcacc agctgacaaa
    18661 ccaaccataa aagccccctt caccctcttc aagttcctgt tcgggtaaat gatattaaga
    18721 ccctgaatgt cattctactt ttatgatttc acatcacagc cagcatctcg accgagctcc
    18781 ccgtttcaca tcctactaaa tcgcgcatac aactggagct atctccacca aatcatgcac
    18841 ttcattatat caacagataa caaaaagccc gacagaagta cccgtcgact tatccgaagc
    18901 catgtaatgc aaggcataaa caaagggcgg cctcgatacg accgacggaa aaaacccagt
    18961 ccgatacagc aggatcagct tccatcgcca caattaacga aaatgtatca ggactccgac
    19021 atcatccagt cgaataaact agtcgtgggg cctgatccgt ctttcgctca attcgccgtt
    19081 caagtggact cccgcacctt cgctgatata ctacgatgta agtaggttct cccgtatcct
    19141 aacccatcgt tcgtttgcgt agctaacgcg aataccattt agtcgccaaa ttatcaatgc
    19201 aaatgttctt cccattgggt ttcttgattg atttcgactg tagggataaa tcctggttcc
    19261 acgactctat acgctccgat gcagcgtatc tgcatctcac cgtgtccgca tcagaggtgt
    19321 tcatgggctc ggttcacggt cgacagaatg ccgatgaact acttgctaat cgcaggacca
    19381 tgctccattt tgcaaagggc gtgcagatcc tccgcgagag actgacgggc gtcgatctcc
    19441 agacaaaaat atccgacttc actgtacgaa ctgtactaat gctagccatg acagcgcatc
    19501 tgatgggcga atcggaggtc gcgcagaaac acatggaggg cattcgaaca atcatggatc
    19561 ttcgaggagg tctgcgctta tttgaaagcc agaagattct catcgagctg ttcaggtaag
    19621 ccacctactt ccccataaca gccaacctac tacaataatt gaccaccatt agatgggacc
    19681 taggcctcgc cctccaaaac aacaccacgc ccatgttctt cagagacaaa ttcctcgagc
    19741 cactcactcc attccccacc atcttcaacc ccaccttgaa ccaaattaac aatcccatcc
    19801 tcccccaact ccatttagac ccaaccctaa agacaacctt tcacgtcctc caaaacttct
    19861 gcaccctaat caacacaagc atcaccgaga ccccccaacg ccgcctctcc ccagacatca
    19921 tcccttccac gctctcctcc gtaatgtatc gtcttctcca aatgcctttc cccatgaaca
    19981 gcaacaacga agccttccgt ctaggtctcc tcaccttctg ccatcatacc tttcttcagt
    20041 ggcaggataa gacactgcct ttcgtatatt tccctgcctc gtatcaatca tgccttttat
    20101 cgttgatgga acaatgccaa cgtcgtcaag atgaagagga ggattcctcg gagcttattc
    20161 tctggctatt gatggtcgga atccttgcat tgccgccgct gccgtcgttt ctggggacgg
    20221 atctctggat gagggggtat ttgcgggagt cgttggagaa gttggagatc aggacgtggg
    20281 gggagttgcg ggggattatg aagaggtggg tgtgggtgga tttgatgcat gatcttgctg
    20341 gggagggagt gttgggtgat gtgctgaaag tataattggt gctgacagta gtttcatttg
    20401 gtatcctgtt gtgtatcggc atcaaacact aagagtaatt atctttaaat ggtgaaatta
    20461 gggaatagca gtactaatct atttgtctta attggaaagg tggcgaacga cttcgactgt
    20521 cgtgtcataa ctgacttaat atgtggcgct gttactctga ttaagggtaa tcttcaccct
    20581 actgggctca ctctgtccac tactactaat taaacaccga gaagcatcct gtaagatcaa
    20641 gcatactgca tgggcaaaga tactatattc tgtattacca atcatatact tttcaagcag
    20701 gtctatccac atcgccatgg catatctcta gttcttttgc ccctgccagt ttgcttccac
    20761 cgtttgacct ggccatcatc tccaggccga ccacaaataa acgcggtgag ggaaagcaag
    20821 tactgaaagg ggagatcatg tcgttctaca tcacagtgcc gacacccggc cagaataagg
    20881 tgaaaaaaat aaggaaaaat aataaaagaa atccgtaata aacaactgaa ggggttcaac
    20941 atgattgcat tgttcgtgac cacattgtca tcaagctgcg atcccacagc tgggctcacc
    21001 gttatctacc aatcgagcaa atttactgct cagcgggctt ctcgccctca gccggagcgt
    21061 ccttcatctc agcgtcgggc ttctcctcgg ccttcttagc ctcctcttcg gccttcttgg
    21121 cctcctcctc ggccttacgc ttggcctctt cttcggcacg cttcttgttg gcggcctcct
    21181 cctgggcctg gcgctcggcc tcctgcttct cgcggtagcg ctggatgatg ggaccggcga
    21241 cgaagcggat ctcgtccatc ttggccacgt agaccgactt ggtggtgtcc tcaccctcct
    21301 cgtagagcca gtcctgaaca actcaattag tttctggtaa acgacagatg gaacgaacgt
    21361 tctgaaaact tacctcggtg tcggtcagct tagcccgcag cttgtccttc tcctcttcgt
    21421 tggcgaactc ggagtagacg ccgtcgatct tgtcacgcag ctcgtagatg ctagactcga
    21481 gctcgttctt cttctcatcg gtctcggcaa tgagcttgtc ctccatgtac atggagttct
    21541 cacgctcagt ccaggcgttc aggacggact catcggtgga ggtagtgcca gtcgagatgg
    21601 gcagatcgcc cttgcgaacc tgcttcttga ccttgcgagt cttcttgggc tgctcaccat
    21661 ccttgccatc ggtgtccatg gcctaatcag ttgtcagtaa tcggaacatc tcgcgaaaat
    21721 gacctcgggg gtttatcact cacatcaccc tcctcgggaa caggctcctc gacttccatg
    21781 tcctcaacgt agtatccgga ctccaggttg aggataccgt gaaggttcag acgagccttg
    21841 agcttgcaga tcatgaagtc gtcgttggca tcagccttga cacccttgac ggagaagcgg
    21901 cccacccagg ggttgacctt gccgggcagc atctcgggct tggcgtagcg ggcctcaaga
    21961 tcgaagggct gcttgcggta gaaggtaagg atcttggtcg aaggcataac gttgccgcgg
    22021 ttgaaaacgg tcaggctggt gtcctcgtcg gggatgtcgg ccgactgctc ccaggtgaat
    22081 tcgatggggt agttgacgat atcgtgaacg gagaagtcac gcacacggaa gacgggggag
    22141 aggatggcac agctgaaagc acagccgcga gcaatggcct catcctggtt gagggtgaaa
    22201 gagagggtct tgccgaagaa cttggcgacg gcgtccttga tggcgggcac acgggtgcag
    22261 ccaccaacca tctcgacgaa gtcaatgtcc tcgggcttga gcttggcctc agccagggct
    22321 tcctcaatgg gaacggtgac ccggtccaga aggggcttga ccatggtctc gagctcctca
    22381 cgcttaacga tggcgcggac gtcgacgtcc tccatcagag actcaatgct catgggagca
    22441 gcagggttgg ccgacaggac cttcttcatc ttctcggcag cggccagggt acgagaccag
    22501 gccttggggt gagagcggac atcgatcttg aacttctcct tgaactcatc ggcgaagtgc
    22561 tcggtcaggg cacggtcgaa gttgcgacca ccgaagtgac ggtcgtaggc agtagccttg
    22621 acgttgagct cacccttgcg gaactcgacg atggaggcag tgtagtcgct gtagccgata
    22681 tcgacgaaca tgacccgacg gggcttctcc tcagggccgg gcaggtcgac cttagtgata
    22741 ccgtaaccga gagcggtggc ggtggtgtcg ttgatcaggc ggagaacctt gaggccagcg
    22801 atctcaccgg catcgagcat ggcgcggcgc tggacgtcgg tgaaccaagc gggaacgctg
    22861 atagtgacgt cggagacagg aagcttcagc tccttggagg tgatgtcccg gatcttggtc
    22921 aggtacatgg cgaccagctg agtagccgag aacttctcct tctttccgag gtagctgacc
    22981 tcggcaccgg cctggccatt gacatcgcaa agctgagccg tggtgtactc ctgctcgatc
    23041 gcaacatcgg ggtcgctgaa tgtgcggccg atcaggcgct tcaggttgcc gaccgtgttc
    23101 ttgaggttgg aagtctcttg cgtcttagcg gcctcaccga gagctctgca gcgggcattg
    23161 aagccaacaa gggaactgtg tgggagaaaa acaagtcagt acacggctga gtaacaggta
    23221 tactgggcag ggcagcaaat atggcgccga cataaaaatc atgataagca agtgaatggg
    23281 cgaacttacg gagtagatct gttggaaact tcgttggtga tctgtaagcc atcacaatgg
    23341 accagttagt aattacttga ggtcaatatg acgagcggat gggcagcgct cggaggggaa
    23401 aagaaaattg ggtagagggg gaagagtgac gcacaatatc aatacccttg ttacgggcaa
    23461 caccgacctt ggtgctctgg gcaccgaaat ctataccgac gacagacatt gtctagatga
    23521 ggaagaggta gagagggggg agaagagagt ggggggaaga aaaaggggag agaggggaaa
    23581 gaagaagaag tagaagagtg atggagagga tgaaagagga aaaaagtgga agatgggact
    23641 gagggggaga ggttggggga ggatccaaag agggcagaga aaagagcgag acggaggggg
    23701 agaatttgca ctgcgagaac tgcaggaccc gccactaaag ctcgcgggcg gtgaggcgtc
    23761 gagtttccaa cgtgggcacc gctggctcgt cagtcactga aactagtagt atctatcagg
    23821 cagatactat ctaggcgcaa attcgatggg gggttccact tgggagacaa cttaaaaatg
    23881 tataattacg cactagagga gatcaatgca gacaaaaaaa tatatataag aagtaggtgt
    23941 tcccgggtcg gaggattaca ggaataaata agggacctgg cgctcgcaag catcccagct
    24001 cagcttcacc ggcttctttg ggcgctcgtc gaaccttctg gctgctgctc gacgcctccc
    24061 acctttcacc gctccccgtg tgccggcaga accctacctg accgctttgg cggggcttat
    24121 cgatagttca gagtttttct cccgttggtg atgactcatc atgtgcatat ctttttggcc
    24181 actcctgcgt ttcagttaac tacgagggtg tgtttggcac tctatagctg gtgttaaacg
    24241 tctgatagac ccggatactg cagctggcat aacggtatct tacggtctca ttggtttgca
    24301 gacttctgtc gagaagaatc atccgatcat catattccaa atgttgtgtc atgcttggta
    24361 acatgtaaac atccattcgt cttactctcc tggttatcgg gaccaaatag agttgacgcg
    24421 actttaccat acgcacatcc atgatttcag ggaatagtaa ctttggcttg gttgatcgtg
    24481 cgagaaaaag ttattagaat acaaaggatg tgaatagaca acggatcgaa aagccatgac
    24541 tgaatgagaa tcgagtaact agttcattac acatgtgtgc atgaagacag gctctagtac
    24601 tctggtcagt cgggctctat tcccaagtca ctctcatgcg ctgcctttcg gttcaaacca
    24661 tttgttctgg ttgcatatat ctcctcttct gcctcggaat cctgctagga cgctttgtat
    24721 atttcggctg tggcaagtgt tcatggggct gagacatatt cccaggaaca gccctagatt
    24781 gttgcatccc agattgcggc acacttgacg atagtaccgg ggcttttccg ctcggaattc
    24841 cgctccctga ctcaatagta tgcatttcat acgcccggtt gtcttccagg tcctcgttag
    24901 actgcacgtc caggccacgc tctccaccgt ctgcctcctg tgtgtgtaga agtccggtgg
    24961 actcctgcgc ctggctacca atgtagagtt
//
