LOCUS       KZ851958.1             21122 bp    DNA     linear   PLN 20-AUG-2019
DEFINITION  Aspergillus niger.
ACCESSION   KZ851958
VERSION     KZ851958.1
KEYWORDS    .
SOURCE      Aspergillus niger
  ORGANISM  Aspergillus niger
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Eurotiomycetes; Eurotiomycetidae; Eurotiales; Aspergillaceae;
            Aspergillus.
COMMENT     'Annotated using funannotate v1.6.0-df4262f'.
            ##antiSMASH-Data-START##
            Version      :: 5.0.0
            Run date     :: 2020-11-02 07:38:58
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 80882
            Orig. end    :: 102004
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..21122
                     /aStool="rule-based-clusters"
                     /contig_edge="False"
                     /core_location="join{[91677:>92004](-), [91278:91631](-),
                     [90882:91210](-)}"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(join(10001..10328,10397..10749,10796..>11122))
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     cand_cluster    1..21122
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..21122
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="1"
                     /rules="(Terpene_synth or Terpene_synth_C or phytoene_synt
                     or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps
                     or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /tool="antismash"
     mRNA            join(1138..2256,2316..2626)
                     /gene="MIC33"
                     /locus_tag="M747DRAFT_299891"
                     /product="Putative mitochondrial 2-oxoglutarate/malate
                     carrier protein"
     gene            1138..2626
                     /gene="MIC33"
                     /locus_tag="M747DRAFT_299891"
     CDS             join(1358..2256,2316..2364)
                     /codon_start=1
                     /db_xref="InterPro:IPR002067"
                     /db_xref="InterPro:IPR018108"
                     /db_xref="InterPro:IPR023395"
                     /db_xref="PFAM:PF00153"
                     /gene="MIC33"
                     /locus_tag="M747DRAFT_299891"
                     /note="GO_function: GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]; GO_process: GO:0055085 -
                     transmembrane transport [Evidence IEA]"
                     /product="Putative mitochondrial 2-oxoglutarate/malate
                     carrier protein"
                     /protein_id="ncbi_M747DRAFT_299891-T1"
                     /transl_table=1
                     /translation="MASPTAAKEPQPAVDFLHHPYTRAALPFVNGGLAGMTATVVIQPI
                     DMIKVRLQLAGEGVRTGPRPSAFGVARDIIASGKALDLYTGLSAGLLRQAVYTTARLGF
                     FDTFSKTLNKRAEAANRSVTFAERAGAGLAAGGIAAMIGNPADLALVRMQSDGLKPPEA
                     RANYRSVMDALFRISKHEGVPALWAGAFPTVIRAMALNVGQLTFFAESKAQLKKHTSLS
                     TQNQTFAASAIAGFFASFLSLPFDFVKTRLQKQQKDPKTGRLPYKGVLDCARKVVQEEG
                     WLRFYRGFGTYYVRIAPHAMVTLIVADYLNLITK"
     CDS             complement(join(<2711..3593,3668..4410))
                     /codon_start=1
                     /db_xref="InterPro:IPR004181"
                     /db_xref="InterPro:IPR013083"
                     /db_xref="PFAM:PF11789"
                     /locus_tag="M747DRAFT_374798"
                     /note="EggNog:ENOG41; GO_function: GO:0008270 - zinc ion
                     binding [Evidence IEA]"
                     /product="hypothetical protein"
                     /protein_id="ncbi_M747DRAFT_374798-T1"
                     /transl_table=1
                     /translation="MPKRSRPPPPTATPGPSGRNRNRDRDTTPPLPPYQPPTSTLTTLS
                     HQPTTAPALSALLATHTSSTLKTHLQHAQEKLTDAAGEINERLTDAKERSKKSRERRRN
                     IRSHTLENNNNNGEGVDEEGGDSEDEGIEEFEERVAQTTKVLEETIRGVIDAEVRGEEL
                     GRVISGLEGGVAERVRVRGVRRSQRGIGRRLRGHHGEDEEDEDGEEGVDVDVDEDEEGA
                     VPFLAQFEDELRGKMEEYEGLSLTRRYSTNNSYIGFYKIIHEAKHIGDEIPPPPHPSTW
                     FAHLEDPHSQSQPQSHPSASTSTSTTTTRQTRPTRARPQPPSEEEDEDDDDEIAIQTER
                     ISLKCPLTLLPFRDPVTSTKCPHSFEREAIFTMISGSNQMVPDPRGSSGTGRAKRVRSV
                     KCPVCEVQLTEFDLRSDPVLMRRVKRAEMAELRRREREMLDDGEDDQDGGDGGGGGGKR
                     KRSGRRRGSAVEVDDGDSDDDSGEDDGVERIRVKRERGMSVAARIKQERAVSMVGDGDG
                     DVEEVDMDEEGGGEEGGYDSMYDE"
     mRNA            complement(join(<2711..3593,3668..4544))
                     /locus_tag="M747DRAFT_374798"
                     /product="hypothetical protein"
     gene            complement(<2711..4544)
                     /locus_tag="M747DRAFT_374798"
     mRNA            complement(join(4758..4851,4909..5075,5128..6668,
                     6950..>7111))
                     /gene="ABD1"
                     /locus_tag="M747DRAFT_374799"
                     /product="mRNA cap guanine-N7 methyltransferase"
     gene            complement(4758..>7111)
                     /gene="ABD1"
                     /locus_tag="M747DRAFT_374799"
     CDS             complement(join(4817..4851,4909..5075,5128..6668,
                     6950..>7111))
                     /codon_start=1
                     /db_xref="InterPro:IPR004971"
                     /db_xref="InterPro:IPR029063"
                     /db_xref="PFAM:PF03291"
                     /gene="ABD1"
                     /locus_tag="M747DRAFT_374799"
                     /note="BUSCO:EOG09262QTY"
                     /product="mRNA cap guanine-N7 methyltransferase"
                     /protein_id="ncbi_M747DRAFT_374799-T1"
                     /transl_table=1
                     /translation="MASKEEERTGQRPSISMYDPARDRWEEQPVVPAEPASASASIEAT
                     PTQTSEAKPVHDSTVTSTSESLHLPQTTTIEPSQQPEQQQKQPPIPTPPSSQSRRKHKI
                     NKMGDYYRSGSADAYAEQSSPAADSHKRKLEDETSEQQPPADQANDRPISKRKRLEERH
                     QKLRKRGQAPPSAYSRRDGDETAARAAPRPRSPSPPLPPRSPSPEVQARQRKRPGGGAR
                     RGLVDPQTLRRRQEERERALEEDAMRNSQSRGVTDIVRQHYNAVPQRGREWRKTESKIK
                     GLRSFNNWVKSTLIQKFSPDEEFVARAIGTKDWADGTGPPPMEEKRLLVIDLGCGKGGD
                     LGKWQLAPQPVDLYVGLDPAEVSIIQARERYAGMRSGRGPRGGRRGGPPLFHGEFRSKD
                     CFGEWLGDVDIVQQVGIDPNVGPGGSMMASRWGGGGFDVVTSMFAIHYAFESEEKARQM
                     LRNVAGCLKKGGRFIGVCPNSDIISARVAEFNAKRKDREAAKQDAEPEDGEVEEEAKAE
                     WGNSIYRVRFPGDTPEDGIFRPPFGWKYSYFMEEAVGEIPEYVVPWEAFRALTEEYNLE
                     LQYRKPFMEVWRDEKDDPELGPLSERMGVRDRTTGELTMTPEEQEAVSFYHAFCFYKV"
     mRNA            complement(join(<7607..8158,8222..8553,8608..8787,
                     8819..>9248))
                     /locus_tag="M747DRAFT_289821"
                     /product="cytochrome P450"
     gene            complement(<7607..>9248)
                     /locus_tag="M747DRAFT_289821"
     CDS             complement(join(<7607..8158,8222..8553,8608..8787,
                     8819..>9248))
                     /codon_start=1
                     /db_xref="InterPro:IPR001128"
                     /db_xref="InterPro:IPR036396"
                     /db_xref="PFAM:PF00067"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 156.5; E-value: 1.8e-47)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="M747DRAFT_289821"
                     /note="GO_function: GO:0016705 - oxidoreductase activity,
                     acting on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]; GO_function: GO:0020037 -
                     heme binding [Evidence IEA]; GO_function: GO:0005506 - iron
                     ion binding [Evidence IEA]; GO_process: GO:0055114 -
                     oxidation-reduction process [Evidence IEA]"
                     /product="cytochrome P450"
                     /protein_id="ncbi_M747DRAFT_289821-T1"
                     /sec_met_domain="p450 (E-value: 6.6e-37, bitscore: 118.9,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MTPPLLPTSLISAILGITAHLTYFIHADLEKHVVFLVNCLIFWPS
                     LGLIALFILGYRDISQWIGPAILSFHFSLLASIVIYRYFFHALDGFPGPKLARITALWD
                     FKNTVLNAKWYIKVKEMHGVYGDVVRISIPPLFHSSHVIWNYPSTTHLRSKISTAWGPH
                     ASRDRSTIYIIRIDRCKWREIRRFIRRGGDCGIGGLRRKAALAGYEPYLLEHCKDIVRV
                     IESRSSQAQEATALIDGFAWDSMGIFAFGKSFNMLHGEPPKMLQMMRMMGRGASALLSS
                     SWLVILMRGMVGVRRFTDRWLEWCAQCVEERSRVETNRRDLFSYLIEELSSEGDQSIGG
                     VDGDLVRDSELAITAGSDTAASTLNALFYLLARHPDKLRRLQEEIDTAVPADEELSHAA
                     LVKKPYLEGCINESLRLCPAVLSGLQRETGPEGLRTAGVYIPPGMIVSVPTYTVQRGRS
                     LTFPVKIRADFLSRRPAQLPPSKRIHPRKVVHPARASHS"
     mRNA            complement(join(9958..10328,10397..10749,10796..>11122))
                     /locus_tag="M747DRAFT_269521"
                     /product="terpenoid synthase"
     gene            complement(9958..>11122)
                     /locus_tag="M747DRAFT_269521"
     CDS             complement(join(10001..10328,10397..10749,10796..>11122))
                     /codon_start=1
                     /db_xref="InterPro:IPR000092"
                     /db_xref="InterPro:IPR008949"
                     /db_xref="PFAM:PF00348"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: fung_ggpps2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182:Polyprenyl synthetase (Score: 100.2; E-value:
                     1.8e-30)"
                     /gene_kind="biosynthetic"
                     /locus_tag="M747DRAFT_269521"
                     /note="GO_process: GO:0008299 - isoprenoid biosynthetic
                     process [Evidence IEA]"
                     /product="terpenoid synthase"
                     /protein_id="ncbi_M747DRAFT_269521-T1"
                     /sec_met_domain="fung_ggpps2 (E-value: 2.5e-117, bitscore:
                     382.1, seeds: 17, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MAALPDVASIPLPLVATLGIAPLVFYLVLDRFGPLWPNSKTFLIG
                     KKKPETVTSFECPYAYIRQIYGKHHWNPFVQKLSPRLKDEDPAKYKMVLEIMDAIHLCL
                     MLVDDITDNSDYRKGKPAAHRIYGPSETANRAYYRVTQILNETVQRFPKLAKFLLQNLE
                     EILEGQDLSLIWRRDGLGSLSTVPEERVAAYRKMASLKTGALFRLLGQLVMEDQSMDGT
                     MTTLAWCSQLQNDCKNVYSSEYAKAKGALAEDLRNRELSYPIILALEAPEGHWVASALE
                     TSSPRNIRKALAVIQSERVRNACFRELKSASASVQDWLAIWGRNEKMNLKSQQT"
     CDS             join(<11746..12066,12145..12263,12317..12530)
                     /codon_start=1
                     /locus_tag="M747DRAFT_289825"
                     /product="hypothetical protein"
                     /protein_id="ncbi_M747DRAFT_289825-T1"
                     /transl_table=1
                     /translation="MDGFDHSTAPQEYNELKWLANIFVVGMAVGWVAHYVEMIHTSFRD
                     RTYCMTIGGLCINFAWEIVFCTMYPAKGIIERVAFLVGISLDLGVIYAGIKNAPNEWHH
                     SAIVGPAQAYTWGAIACQLFISIGNVFQLLSRGNTRGASWTLWISRFFGSTSAIGFALV
                     RYFRWWEAFSYINCPLVIWSVAMFFLFEILYGVLFCSVKRQEKSSQRGIKHKER"
     mRNA            join(<11746..12066,12145..12263,12317..12595)
                     /locus_tag="M747DRAFT_289825"
                     /product="hypothetical protein"
     gene            <11746..12595
                     /locus_tag="M747DRAFT_289825"
     mRNA            join(13018..13505,13578..13849,13907..14277,14334..>14792)
                     /locus_tag="M747DRAFT_269528"
                     /product="flavo protein monooxygenase"
     gene            13018..>14792
                     /locus_tag="M747DRAFT_269528"
     CDS             join(13204..13505,13578..13849,13907..14277,14334..>14792)
                     /codon_start=1
                     /db_xref="InterPro:IPR002938"
                     /db_xref="InterPro:IPR036188"
                     /db_xref="PFAM:PF01494"
                     /gene_functions="other (smcogs) SMCOG1087:hypothetical
                     protein (Score: 252.8; E-value: 1.1e-76)"
                     /gene_kind="other"
                     /locus_tag="M747DRAFT_269528"
                     /note="GO_function: GO:0071949 - FAD binding [Evidence
                     IEA]"
                     /product="flavo protein monooxygenase"
                     /protein_id="ncbi_M747DRAFT_269528-T1"
                     /transl_table=1
                     /translation="MANTQQPQFRVLIVGGSVAGLTLAHCLERANIEYLILEKGDDIAP
                     QVGASIGIMPNGGRILEQLGLFGEIERVIEPLHQANISYPDGFCFSNVYPKVLGDRFGY
                     PVAFLDRQKFLQIAYEGLTKKHNVLTRKRVVEVRQLEHGITVAVADGTEYEVDLVVGAD
                     GVHSRVRSEIWKMAGENRPASVSRRERRSMTVEYVCVFGISSAIPGLEISEQINGIYDH
                     LSILTIHGRHGRVFWFVIQKLDRKYVYPDVPRFSDEDAVQLFERVKHVRFWKDICVGDL
                     WKNREVSSMTALEEGLFETWHHERMVLIGDSVHKMTPNFGQGANCAIEDAAALSSLLHD
                     LINARGVCKPSNSQVQHLLQQYQETRYSRMVGMCRTAASVSRIQARDGILNTVFGRYWA
                     PYAGNLPADLASKVMADAEVVSFLPLPGRSGPGWEMYRRKGKREQIQWVLIIFSLITLG
                     GLCIWLQSNA"
     mRNA            complement(join(14830..15772,15823..15906,15956..16538,
                     16705..16857,16896..16976,17107..>17151))
                     /locus_tag="M747DRAFT_289833"
                     /product="zf-C3HC-domain-containing protein"
     gene            complement(14830..>17151)
                     /locus_tag="M747DRAFT_289833"
     CDS             complement(join(15015..15772,15823..15906,15956..16538,
                     16705..16857,16896..16976,17107..>17151))
                     /codon_start=1
                     /db_xref="InterPro:IPR012935"
                     /db_xref="InterPro:IPR013909"
                     /db_xref="PFAM:PF07967"
                     /db_xref="PFAM:PF08600"
                     /locus_tag="M747DRAFT_289833"
                     /note="EggNog:ENOG41; GO_component: GO:0005634 - nucleus
                     [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding
                     [Evidence IEA]"
                     /product="zf-C3HC-domain-containing protein"
                     /protein_id="ncbi_M747DRAFT_289833-T1"
                     /transl_table=1
                     /translation="MDKCKLIIFGDSRRSISGQSSIHDGLYHKECLMTSVNWYRTQFIQ
                     LGTRSAACKKTSLSFLAEMTFFRGCRDPDRYDQPCPVSDVLSGLSHIIRHQLRGHSKIQ
                     TPLSQRPLQLHNAITSACWKMSYAVETKKRKFHRVLESLTKPSTSDSTKSATAEAPTTA
                     RDASKKKARLDAPNFSLARNSLLKVARPSSRDSSVSSTSRPSFVPWDRERFLERLETFR
                     RVDRWAPKPSAISEVEWAKRGWVCTDVARVTCAGNCGGSVVVKLPDELDELDGFDADKV
                     QERKEVRAKLVDEYVERLVKGHGETCPWRNKGCDATIHRLPLANPDIAISGLEKRYSNL
                     IKMADQLPAADVIHTPESFDIEALIKILPASFNGPGESTRMESIENNTEGENGKENAHN
                     SEPEPFVPRNAFILAFFGWDSVPDGTAGLVGCSVCFRRLGLWMYKPKANGDEALYDSLE
                     VVNEHMDYCPWVNGKAQSGTGRATEKLEGLRSGWELLGQALNVRHRRLNRSTTSGDSRA
                     VSEVPSTDEPVVDDVNPEVKKASDREWWAKLRRMRQVLNVSSPRKKPTSQ"
     mRNA            join(18576..18718,18795..19329,19384..19483,19544..19709)
                     /locus_tag="M747DRAFT_299894"
                     /product="aflatoxin biosynthesis ketoreductase nor-1"
     gene            18576..19709
                     /locus_tag="M747DRAFT_299894"
     CDS             join(18676..18718,18795..19329,19384..19483,19544..19615)
                     /codon_start=1
                     /db_xref="InterPro:IPR002347"
                     /db_xref="InterPro:IPR020904"
                     /db_xref="InterPro:IPR036291"
                     /db_xref="PFAM:PF00106"
                     /db_xref="PFAM:PF08659"
                     /db_xref="PFAM:PF13561"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     102.5; E-value: 4.3e-31)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="M747DRAFT_299894"
                     /note="GO_function: GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /product="aflatoxin biosynthesis ketoreductase nor-1"
                     /protein_id="ncbi_M747DRAFT_299894-T1"
                     /transl_table=1
                     /translation="MSSPTIYLITGASRGIGLALTQTLLLLPNTTVIATMRNPTTNSLY
                     TNPPPTSPTSTLILLPLDIQSTTSITTAIETLKSKHNITHIDTVISNAGYYNDATHRVD
                     NIPLSTVQSHLDVNTLGTIRLFQGVYDMLKKSTKPMFVSVSSFLGSIGGLEEEFFPGAA
                     YGVSKAASNWVTRKMHVENEEMVCFMVHPGFVKTEMGNACAKSIGLEEAFAEPKECAEA
                     LVKLIASATRETVGGRFISWRGEEVPF"
     mRNA            19995..21097
                     /locus_tag="M747DRAFT_289838"
                     /product="NAD dependent epimerase/dehydratase"
     gene            19995..21097
                     /locus_tag="M747DRAFT_289838"
     CDS             20045..21007
                     /codon_start=1
                     /db_xref="InterPro:IPR001509"
                     /db_xref="InterPro:IPR036291"
                     /db_xref="PFAM:PF01370"
                     /db_xref="PFAM:PF13460"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score: 94.8;
                     E-value: 1.1e-28)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="M747DRAFT_289838"
                     /note="EggNog:ENOG41; GO_function: GO:0050662 - coenzyme
                     binding [Evidence IEA]; GO_function: GO:0003824 - catalytic
                     activity [Evidence IEA]"
                     /product="NAD dependent epimerase/dehydratase"
                     /protein_id="ncbi_M747DRAFT_289838-T1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 4.8e-08, bitscore:
                     24.1, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MPLIFLTGGSGYLGHAITTHALSKNYTIHSLSRSPESDAKITSLG
                     AVPIRGDLTTHSVLREQSQKADIVIHLADPMAGNYSLPYEERIRIDDEAVTAIAEGLVG
                     TNKPLVVTSGSLVVAATGTETDENSALWEEGKALNERIVSERKNLRWWEEKGVRVIVIR
                     LPPFVYGRGGSGVGLFMGMFWNGGDGGKKEVKVVKEAEEVVTSAVHVEDAADLYLLAAE
                     RAGAGEVFNGCSEWGVTFGELGRAMADVLGVEVGLVGFEEAKGVWGEFFARFLSTENRA
                     SGGKAMRVLGWAPKKVGIVEEVRHGSYVEVAERLKNGAA"
ORIGIN
        1 tgtcttgttt ctagcaggca gtgctactac atagtagctg gtataccggt gttgacgtcg
       61 aaaaaagaat atgttatatg accagatatc tccgaaggga cagacagtac ctaccttaga
      121 ctgatcggcg agaccaagct ttgggaatat ttcccattca cagcatttat gactaatcgc
      181 tagtcaagac tggggaagga ggagagataa cctcgggaag gcggcaagaa gcagcgcaaa
      241 ccggaccgtt ctcgtggtta gtcccgatgg ggtttagcgg gggtgtgggg agatacggta
      301 attatgtatg atggacgatt attccccgcc atgacgtttt ggtattagta gctgtttgta
      361 tggatttctg gatatttgca atacactgat agttttcaaa gaatattact gttattggaa
      421 gaagaagtag agttacaaca tcaatagaga agagaacaac ttcatcgaag acacaaataa
      481 catgattaaa aaaaggacat cagacgtggc aaccccgcat tttccagctg gcggcatcgt
      541 gcagcaagta cttactgact gggtatacta ccaaatacta ctaaatcctc atcgatcgct
      601 cgggccttaa gtttggcatc ggctaacaaa agtggggatg gaaatagtta cccagtctgg
      661 agagatttcg actgtcagtc aatcaagtag atactgcttg tttccctggt cggcttctcg
      721 gatggaatcg aaggcataca aatacatcat cgaatccccg tgaatgctac cttgactcat
      781 gcaactcatg cacaggttat aagtatcaga atcacccacc cagacacttg cctccagttg
      841 tacaaccttg caaattaatc cattcactca ctgccaactc tcgcctcctc acttcttcgt
      901 cgccttgcac ctccgcttcc cccatcatct gactgtccca acttctcctc ctcaacaaaa
      961 cccggttcac cacttcctac tgattctcgt cgggcctttt cgtgactcta ccgggttccc
     1021 ctcttcgccc agctgtgcat ccacggtacg ttgaatctcc cctcccgcgt ttcctcacgt
     1081 cacggtcggt catgctgaaa gtgcctggca aagaaaatct gtcctctctt tgctgagcca
     1141 ggcactcgat tcttttcatg gctagatggt cgtctctcca ctacccccca caccgtgtat
     1201 cgtgttgtct tttatttcgc gtttcatcct tcgttcatct gtattcctcc tcttgaatcc
     1261 ttcgttcggc gcgtctcatc cgcctcacct tccaaagtgt tcgcattaac cctcgttcac
     1321 cctctagatc tggtgtgaat cctgcttcct cgtcaacatg gcctccccca ccgcggccaa
     1381 agagccccag cccgccgtcg atttcctcca tcacccttac acccgtgctg ctcttccctt
     1441 cgtgaatggt ggcctggccg gcatgaccgc cacggtcgtg atccagccca tcgacatgat
     1501 caaagtccgt ttgcagctcg ccggtgaagg tgtgcgcacc ggtccccgcc cgtctgcctt
     1561 tggcgtggcc cgcgacatca ttgcctcagg caaagcactt gatctgtaca ccggtctgtc
     1621 ggctggactg ctgcgccagg ccgtttacac taccgcccgc ctgggtttct tcgacacctt
     1681 cagcaagact ctcaacaagc gtgccgaagc cgccaaccgc agcgtcacct tcgccgaacg
     1741 tgccggtgcc ggtctagctg ccggaggtat tgccgccatg attggcaacc cggccgatct
     1801 ggcactggtg cgtatgcagt cagacggtct caaacctccc gaggcgcggg ccaactaccg
     1861 ctccgtcatg gacgcgctct tccgcatctc caagcacgaa ggtgtcccgg ctctgtgggc
     1921 tggtgctttc cctaccgtca tccgtgccat ggcgctcaac gtcggccagt tgaccttctt
     1981 tgccgagtcc aaggcgcagc tgaagaagca cactagcctg tcgactcaga accagacctt
     2041 tgccgcgtcc gctatcgcgg gattctttgc cagtttcctc tccctgcctt tcgactttgt
     2101 caagactcgc ctgcagaagc agcagaagga tccgaagacc ggtcggctcc cctacaaggg
     2161 cgtcttggat tgcgcgcgca aggtcgtcca ggaggagggc tggttgcggt tctaccgcgg
     2221 tttcggaacg tactatgtgc ggatcgctcc tcatgcgtta gtgtccccac cattttctat
     2281 cagactagtg cccttggcta accccagacc cacaggatgg tgacgcttat cgtggccgat
     2341 tatctgaact tgattaccaa gtagcagcat tgattcaaca tgatattgtt ggcttgtcga
     2401 caactacttg acttgaactt ttttttccaa atgccgcggt tgctgtcgtt tgacggtgat
     2461 tattgcacag gtgcggatct ggttgcactg tctggaacag atgcaggaga agatcgaaat
     2521 gccctaatga ttgtggatgg aggatggtgt ttcgatggat ggttgatggt ttcaatggct
     2581 gtttgtattt attatacccg tgattattgc aactacatag cagagattca aatagagata
     2641 ggcaataaat aagtctactc tgtatgcttc tacagaatag aaacatgaat gcttgtagta
     2701 gctagataaa tcactcatca tacatagaat catacccacc ctcttcccct cccccttctt
     2761 catccatatc aacctcctcc acatccccat ccccatcccc aaccatcgac accgccctct
     2821 cctgcttaat cctagcagca acagacatcc ctctctccct cttaacccga atcctctcca
     2881 ccccatcatc ctcaccacta tcatcatcac tatcaccatc atcaacctca accgcactcc
     2941 ccctcctcct cccactcctc ttcctcttcc ccccaccacc acccccgtca ccaccatcct
     3001 gatcatcttc cccatcatcc aacatctccc tctccctcct cctcaactcc gccatctccg
     3061 ccctcttcac ccgcctcatc agcacaggat cactccgcag atcaaactcc gtcaactgca
     3121 cctcgcacac aggacacttg acgctgcgca cgcgcttcgc tcttccagtt ccagatgacc
     3181 ccctcggatc aggcaccatc tgattactcc cgctaatcat ggtgaatatc gcctcgcgct
     3241 cgaaactgtg tgggcatttc gtgctggtca cggggtcgcg gaagggaagg agtgtgaggg
     3301 ggcatttcag cgatatgcgt tcagtttgga tggcgatttc gtcatcatca tcttcatctt
     3361 cttcttcgga ggggggttga ggtcgagcgc gggtgggtct agtttgtctg gtggtagtgg
     3421 ttgaagtaga ggtagaggca gatggatgag attgtggttg agattgagaa tgaggatctt
     3481 ccaagtgagc gaaccacgtc gacggatgag gcggaggggg gatttcgtcg ccgatgtgtt
     3541 tggcttcgtg gatgattttg tagaaaccta tgtaggagtt gttcgtagaa tacctaccac
     3601 catgattccg ttagtaaata aacctggaag taaaatatta ttgggataga aatggggata
     3661 tacataccgt ctcgtcaaac tcaacccttc atactcctcc atcttcccgc gcagctcatc
     3721 ctcgaactgc gccaggaacg gcaccgcgcc ctcctcatct tcatcgacat ccacatccac
     3781 cccttcctcc ccatcctcat cctcctcatc ctcaccatga tgccccctca accttctccc
     3841 aattcctctc tgactcctcc tcacacccct aaccctcacc cgttcagcaa ccccgccctc
     3901 caatcccgag ataaccctcc caagctcctc ccccctcact tccgcatcaa taaccccccg
     3961 aatagtctcc tccaatacct tcgtcgtctg agccactctc tcctcgaact cttcaatccc
     4021 ctcgtcctca ctatcccccc cttcctcatc taccccctca ccattattat tattattctc
     4081 caaagtatga gaacgtatat tcctcctcct ctcccgcgat ttcttactcc tctctttcgc
     4141 gtctgtgagc cgctcgttga tctcgcctgc ggcgtcggtg agtttctctt gcgcgtgctg
     4201 gaggtgcgtt tttagggtgg aggaggtgtg cgttgcgagg agggcggaga gggcgggtgc
     4261 ggtggtcggt tggtgggata gggtcgtcag ggtgctggtg gggggttggt aggggggaag
     4321 agggggggtg gtgtctctgt ctctgtttct gtttcttccg cttggtccgg gggtggctgt
     4381 tggtggtggt gggcgggagc gtttgggcat tttggttgat ttcttttggg tgagagttat
     4441 ttggttgtgg tggtagtgta taattgaggt aaggtgtggg tggtgggttg tggatatagg
     4501 tggcaaggag gatagaggag aagaaggagg gtatatggta tatggtgtag gtttctttgt
     4561 tggtagttct ttgaggctat aacgattatg gataaagata agttgaaagg aacgcgacgc
     4621 gatgcacggc gctaggctgt tttgggaagt atggtctttg gggaagttta tcttatcgat
     4681 atcatatcga taccagctac actttatagg gatagttata ctgtatcata gttggattga
     4741 agcaagtatg gatatggagc tgattatgtc gattaaatcc tatttaccct aattctaata
     4801 ctatgtatct tatccttcac accttgtaga agcagaatgc atgatagaaa cctgtcccgt
     4861 tagcactctc tccttcagct gaagtaaaac ctaagggtgt atacttactg actgcctcct
     4921 gctcctccgg cgtcatcgtc aactcgcctg tcgtgcgatc tctcacgccc atccgctcac
     4981 tcaacggccc cagctccgga tcgtcctttt cgtcccgcca cacctccatg aacggcttgc
     5041 ggtactgcag ctccagattg tactcctccg tcaacctgct tcattagtat cgtaatcaat
     5101 gttccatgga atatcgaatg gactcacgct cggaacgcct cccacggcac cacgtactcc
     5161 gggatctcgc ccacggcttc ctccatgaag tagctatact tccatccaaa cggcggcctg
     5221 aagatgccat cctccggcgt atctccaggg aatcgcaccc gatagatcga attcccccat
     5281 tctgccttcg cctcctcctc cacctcaccg tcctctggct ctgcatcctg cttcgccgcc
     5341 tcgcggtcct tgcgcttcgc attgaactcg gccacgcggg cactgataat gtccgagttg
     5401 ggacacacgc cgatgaaccg gccacccttc ttcaaacacc ccgccacatt gcgcagcatc
     5461 tgacgagcct tctcttcact ctcaaacgca tagtgaatgg caaacataga cgtcaccaca
     5521 tcaaacccac ccccacccca tcgcgacgcc atcatcgacc ctcccggtcc aacattcgga
     5581 tctattccca cctgctgaac aatatcaaca tcccccaacc actccccaaa gcaatccttg
     5641 gaccggaact cgccatgaaa caacggcggc cctcccctcc gtccaccacg aggtcccctg
     5701 cccgaacgca tccccgcata tcgctcgcgc gcctgtataa tggacacctc cgccggatcc
     5761 agtcccacgt agagatccac cggctgcggc gcaagctgcc acttcccaag atcacctccc
     5821 ttaccacatc ccagatcaat caccagtaac cgtttctcct ccatcggcgg cggcccagtt
     5881 ccatccgccc agtccttcgt cccaatcgcc cgcgccacga actcctcatc cggcgagaac
     5941 ttctgaatca acgtgctctt cacccaattg ttgaaactgc gcagcccctt gatcttactc
     6001 tccgtcttgc gccactcccg gccccgctgc ggaaccgcat tgtaatgctg tctcacgata
     6061 tccgtcactc cccggctctg cgagttgcgc atcgcatctt cttccagcgc gcgctcccgc
     6121 tcctcctgtc gccgccgcag tgtctgcggg tccacgagac ctcgccgcgc accgccaccg
     6181 ggtcgtttac gctgacgcgc ctgcacttcc ggcgacggag accgcggagg aaggggcggt
     6241 gagggtgatc ggggccgtgg tgctgcgcgt gctgctgtct cgtcgccatc gcggcgcgag
     6301 taagccgagg gaggtgcctg gccgcgtttc cgcagcttct ggtgtcgttc ttcgagacgc
     6361 ttacgcttgg agatgggacg gtcgttcgct tggtcggcgg gtggctgctg ctccgatgtc
     6421 tcgtcctcta gcttgcgctt gtggctatcg gcagcaggag agctctgctc agcgtaggca
     6481 tccgcagagc cagagcgata gtagtcaccc attttgttta ttttgtgttt gcggcgtgat
     6541 tgagaggatg gaggtgtcgg gataggaggc tgcttctgct gctgctccgg ttgttgagaa
     6601 ggctcgatgg tggtagtttg aggaagatga agagattcac tggtagaagt cacagtagaa
     6661 tcatgaacct atatgaaaaa cccaataaac atcggcaatc agcgtcaaat atcctgcaat
     6721 ggaaagaata tggaacactg agaaatatca cgctcagata gacagacaga cgcgcaggag
     6781 cattttcttt cggagtcttt tatttgcggg aagaatagta atcaccgcct ccgccgagcg
     6841 taagcgccac tttagttcgc agtggatggg ctgcaggact ccacttgctc tctccactag
     6901 ggagacagtt ctcgagtgga ctaaatttaa agagaaatga ccaacttacc ggtttggctt
     6961 cacttgtctg agttggtgtt gcttcgatgg aagcagaagc tgacgctggt tcagcaggaa
     7021 caacaggctg ctcctcccag cggtctcggg cgggatcgta catgctgatg ctgggccgtt
     7081 ggcctgtgcg ctcttcctct ttggaggcca tgatcaagtg agacggaagt aaagggataa
     7141 taagaaacct ccatgaaggg agtagcagtt agacagggac aaagcagttg aagtcagacg
     7201 gaattcgtgc tgcttaagct gagttccttg gttgaaaccc ctgccttaac cgtgtttcct
     7261 gcctggccgg atgcggcctg tgaatggagt gaaacagtaa cggtagatgc ctacggtcac
     7321 tacatgacaa cctactattc aatatcgggt aacataacac tgtattggaa tctatctatc
     7381 tatctatctc tttttgaaga gtagatgata ccttggaata tgtgttgtga aacagtctaa
     7441 tggccccgtt cctcccaatc tatctagcgg ttcttgtcct tcccctggtg gaaactcaat
     7501 gtcgaagtgc cttacaatcg tggaaacgag cagtcgcatc tccatcatcg caaatgcctt
     7561 tcctgcacag gagtacgtgc cgcttgagaa cgcgttcagt gcttccttat gaatgactag
     7621 ctctggctgg gtggaccacc tttctgggat gaattcgttt ggacggggga agttgcgcgg
     7681 gtcttcgtga aaggaaatca gctcttatct tcacaggaaa ggttaatgat ctacctcgtt
     7741 gaaccgtata tgtcggcaca gacactatca tccctggagg aatatagact cccgctgttc
     7801 ggagcccttc cggtcctgtc tcacgctgca atccactcaa gacagccgga caaagacgca
     7861 gactctcatt tatacacccc tccaggtacg gcttcttcac caacgccgca tgagacagct
     7921 cctcatcagc tggaacagca gtgtctatct cctcctgcag ccggcgcagc ttgtccggat
     7981 gtcgtgccag gagatagaac agagcattga gggtactggc tgcggtgtcg ctgccagccg
     8041 taatagcgag ctctgaatcg cgaacaagat ccccgtcaac gccacctatg gactggtctc
     8101 cctcagagct taactcttcg atcaagtagc tgaagagatc ccggcgatta gtttcgacct
     8161 gaaacacatc agcctatacc atccacaact gaagagagac agtaactgca aacatacata
     8221 ccctgctcct ctcctccaca cactgcgcac accactctaa ccatctatcc gtaaaccgcc
     8281 tcactcccac catccccctc atgagtataa ccagccagct cgaactcaat aaggcactcg
     8341 ccccgcgccc catcatcctc atcatctgca gcatctttgg cggttcccca tgcagcatat
     8401 tgaacgattt cccaaacgca aatatcccca tcgagtccca cgcaaagcca tcaattagtg
     8461 ccgtcgcctc ctgtgcttgc gatgatcgag attcaataac ccggactata tctttgcagt
     8521 gctccagaag atacggttcg tagccagcga gtgctagtca ttacagcagc cagtcaatat
     8581 aagattcaaa gaacatgcat gtcaaacctg cctttcgacg taaacccccg atcccacaat
     8641 ctcctcctct tcgaatgaaa cgccttatct ctcgccattt gcagcgatcg atgcggataa
     8701 tgtagatcgt agaacggtcc cttgacgcat gtggtcccca cgccgtagat atctttgatc
     8761 gcagatgggt cgttgatgga taattcccta ggttctattc aatcaattgg ccctgtacaa
     8821 atcacatggg aagagtggaa gagaggagga atactgatcc ggacaacatc cccatacacc
     8881 ccatgcattt ccttcacctt gatataccat ttcgcattca gcaccgtatt cttgaaatcc
     8941 cacagcgctg taatccttgc cagctttgga cctggaaacc cgtccagcgc gtggaagaag
     9001 tatcggtaga tgactatgga agctaacagc gagaagtgaa agctcagtat tgctggtccg
     9061 atccattgag aaatatctct atagccgagg ataaagaggg ctattagacc gagtgagggc
     9121 cagaagatga ggcagttgac caggaagacg acgtgcttct cgaggtcggc gtggatgaag
     9181 tatgttaggt gggcggtgat gccgaggatg gctgaaatga gggatgttgg gaggaggggt
     9241 ggggtcatcg tgttgttttt ggtgggataa gatggtatgg gggcttaaag taataaagtg
     9301 atgggttgtt tggtagggga gtgtataggg gatcaataat agtataggga agggaagtaa
     9361 cccctgattg tttggttgtg gatatggggt atggagacat tatggcaggt atgacagccc
     9421 atgcataagc tctgttgatt agctctagca cagtaagcct gtgcacaata ggttgattat
     9481 gaagcgaacg ccgccttaga ggccctgtac atagacattg aacacgaagc actgtcgcga
     9541 agaagcgagt agaaagaata gtggctgcgg tgagcgcagc gccagcatca atcagatttc
     9601 ctaggctgtc ctgaatccta cgtctgatag atgtgttggc gaagcaggga tacaccagct
     9661 gatggttgtc cgaattgtaa catggttcat gcacgtaccc cctctgtggc ttgcttgatg
     9721 ctaccacaac ctgctcggac tatatatatg gcattactac atccgaagca ggctggacgg
     9781 tattccaggg tcaatgtaag ttttgacgat gacaggaata tcgcacacca attcattgct
     9841 cattgaatga actggactcc aacgtataaa tgttaatata tgctgttttg atctaaccct
     9901 atatgtatag cacaaattaa acccagaacg tatctcaaga agaatgattt ctcaaccctc
     9961 aaaccataag agaaactgta tgcctcaaaa cactgaaaag ctatgtctgc tggctcttta
    10021 gattcatctt ctcgttccgt ccccagatag ccaaccagtc ctggaccgaa gcactcgccg
    10081 acttgagctc cctgaaacaa gcattgcgca ctctctcgct ctgaatcacg gcaagtgcct
    10141 tgcggatatt gcgcggtgag ctggtctcca atgcactggc gacccaatgc ccttcggggg
    10201 cttccagcgc gagaatgatt ggatatgaga gctctcgatt acgcagatct tctgcaagtg
    10261 ctcccttggc cttagcatat tcggatgagt agacattttt gcaatcgttc tgcagctgag
    10321 agcaccacct atctcaaggt cagcttcagc ttcagctaga cttggtgtga tatgcaataa
    10381 accaagcgag ccatacgcaa gagtagtcat cgtcccgtcc atcgattggt cctccatcac
    10441 caattgcccc agcagccgga atagcgcccc tgttttcaat gacgccattt tgcggtaggc
    10501 tgcaactcgc tcctcgggaa cggtcgaaag gctacccagc ccatctcgtc gccagatcag
    10561 tgacaggtct tggccctcga ggatctcttc cagattttgt agcaggaact tggctaactt
    10621 ggggaaccgc tgcacagtct cattgagaat ttgggtgact cggtagtaag cgcggtttgc
    10681 tgtctctgaa gggccatata tccggtgagc tgctggcttg ccttttcggt agtcgctatt
    10741 gtcggttatc tgcttgatgt tagagtgtat ttatataggc ccacggtata catacatcgt
    10801 caactagcat caaacacagg tgaattgcat ccattatctc tagaaccatc ttatatttgg
    10861 ctggatcctc atccttaagc cttggagaca gcttctgcac gaatggattc cagtgatgct
    10921 tcccatagat ctgccggatg taggcatatg ggcactcaaa ggatgtcacg gtctccggct
    10981 tcttctttcc aatcaagaaa gttttggagt ttggccacaa agggccaaat ctatcaagga
    11041 cgagatagaa aactagaggg gcaattccca gggttgccac cagaggaagg ggaatggagg
    11101 caacgtccgg cagtgccgcc atgattcggt ccttcctgag tgggacgaaa tgcagggata
    11161 agaaggttaa cggatgacag cgcggtaccc caatgggctc gcaaagggac gttctcctgt
    11221 ctatatatgt atgctataga caggatactt cagccgtaca ctcatcgtca atggctcagg
    11281 gttctcctct gcacaagctg tttctcgcac aagttacacc atctcccctt ctgtgcggtc
    11341 gagccggcca gaacggttgt tgcctgactc tatctcttga tagaagctga catttgggta
    11401 tggcgacatg ctttagcggc acggcaggag atacagcctt tgaagcctgg tgcactcccc
    11461 tggctgtctt gcagggcttt gaagggcttg agaatagcgc actggtgaca cataattacc
    11521 gagactcctg gtggtcctac ctggtgcgga catcagtcta cttatggaga ctgacagacc
    11581 ttcatggcgt accgtcagca gaacagaacc atggcgccgt atcactagct gaccgcaagt
    11641 catctcacta tataagcacg ctcaggtcat gcaagagaca agtgactcag atctcaacgg
    11701 cgaccaaatt cattcagcat tgaagtgcct cttattttcg ctttaatgga tggtttcgac
    11761 cattctactg ctcctcagga atataacgag cttaaatggc tcgccaatat tttcgttgtt
    11821 ggaatggctg tcggctgggt tgctcactat gtggaaatga ttcacacatc gttccgggac
    11881 cgtacctact gcatgaccat cgggggcctt tgcatcaatt ttgcttggga gattgttttc
    11941 tgcacaatgt atcctgccaa aggcattatc gagcgggttg cctttcttgt tggcatttca
    12001 ctcgaccttg gagttatcta cgcgggaatc aagaatgccc caaatgaatg gcaccactct
    12061 gcaattgtga ggaaccatat gactctcgtc ttcgcagcaa caacactttg ttgtctgagt
    12121 gggcatatgg ctcttactgc ccaggttggt cctgcacaag cctatacgtg gggggcaatt
    12181 gcatgtcagc tctttattag catagggaat gtatttcaat tattgagtcg cggaaacacc
    12241 cgaggcgcat cgtggacgct atggtaagta tttgtctgac ctggtttgag aatcagttgt
    12301 gttgaacgtt cactaggatc tcgaggttct ttggatcaac gtcagccatt ggctttgccc
    12361 ttgttcgata ttttcgttgg tgggaggctt tttcgtatat aaactgccca ctcgtgatat
    12421 ggtccgtggc catgttcttt ctcttcgaga tcctatatgg cgtgttattc tgttctgtca
    12481 agcgacaaga gaagagctcc cagcgtggaa tcaagcacaa ggagagatag atgctttgtt
    12541 gagggattgt gcgtaataga tgcatcagac aggaataagc tgcgggaaga tgtcatatca
    12601 ccggaattgg tagccaggaa cggtatgaaa atagtcgcat gtgcaacaca cagctattta
    12661 ttctggcggc atggcggaga aagttcacgg tgttgtacca ctgcttgtag tgctgtcacg
    12721 agaacggaat ttctgcgtgt catgcaatag acaggtttgg gccggcagaa gaaaagcatt
    12781 taataacagg ataaagcagt gtatatgcta tcttgacaca tgtggctgtc cttttaagct
    12841 gtgtagaata aagcaaggca tacctacctt tctgccattt atgattgcaa gtagacgatg
    12901 gcatgatgaa cagccacgct tgtgacacac agcaactatt ggtaaagtgc atgtaccacg
    12961 agactggctt gcataagccg aagtagcttg actacgcagt tctgccacaa tggcagtgct
    13021 ggatttcgct tgagggtcat tcgttccagc agtgagaata gcaaacactt ggcttaccgt
    13081 gcagtttgga atctttctgc attaggtgca atctcttttg aggtaaaggt atcaacacga
    13141 tatttatacc ataagtgagc cttacctttg attgaggctt ggttactggc gacatccgca
    13201 agtatggcca atacccagca acctcaattt cgcgtcctta ttgtgggcgg ttctgtcgca
    13261 ggcctcaccc ttgcgcactg tctggaacgc gccaatattg agtacctcat actcgaaaaa
    13321 ggagacgata ttgccccgca agttggtgcc tcgataggta ttatgccaaa tggcggacgg
    13381 attctcgagc aactgggcct gtttggggag atcgagcgtg tgattgagcc gttgcatcag
    13441 gcgaatatta gctatccaga tgggttctgc ttcagcaacg tctatccgaa ggttttgggc
    13501 gataggtatg tcaatagtct ctgcgtttac cagtatgcga acaaagaaga gagacggtgc
    13561 tgtggctaag attataggtt cggatatccg gttgcgttct tggaccggca gaagttcctg
    13621 caaattgcat atgagggtct gacaaagaaa cataacgttc tcacccgtaa aagggtagtt
    13681 gaagtgcgac agttggagca tggaattact gttgctgtgg ctgatgggac agagtatgag
    13741 gtggatctcg tggttggtgc ggatggcgta catagtcggg tgagaagtga gatctggaaa
    13801 atggccgggg agaatcggcc tgcatctgtt tcgaggcgtg aaagaagaag tatctgccgt
    13861 ccctcacctt ctttgtgctg ggtgcaatca acactaacat aagcaggcat gactgttgaa
    13921 tatgtctgcg ttttcggaat ctcgtcggcc atcccagggc tcgagataag cgaacagatc
    13981 aacgggatct atgaccatct atccattctg acaatccacg gcagacatgg tcgggtgttc
    14041 tggttcgtga tccagaagtt ggatagaaag tacgtctacc ctgatgtccc gcggttctca
    14101 gacgaggatg ccgtacagct cttcgaacgg gtcaagcacg tgcggttctg gaaagacatc
    14161 tgtgtggggg atttgtggaa aaacagagag gtatcctcaa tgacagcgct ggaggagggt
    14221 ttgtttgaga cgtggcacca tgaaaggatg gtgttgatcg gcgatagcgt tcacaaggtg
    14281 cgtggctaag agaattgaag tgatatcgtt cggcttactt agtctgcaat cagatgacgc
    14341 ccaactttgg ccagggagcc aattgtgcca tcgaggatgc tgccgcgctc tcctcccttc
    14401 tacatgatct catcaacgcc cgcggagttt gcaaaccgtc aaattcccag gttcagcatc
    14461 tcctccagca gtatcaggag actcgatact ctcgcatggt aggcatgtgt cgcaccgcgg
    14521 cttcagtttc tcggattcag gcccgagatg gcatcctcaa caccgtcttt ggacgatatt
    14581 gggctcctta tgctggcaac cttcctgctg acctggcatc gaaagtaatg gcagatgcag
    14641 aggttgtttc ttttctgcct ttgccagggc gctcaggacc gggctgggag atgtacaggc
    14701 ggaagggaaa gagagagcag attcaatggg tgcttataat cttcagctta attacgcttg
    14761 gcgggttgtg catctggctt caaagcaatg cttcttatgt cgttgagtaa atgataactt
    14821 ttgttctccg atctttctct gattgagtat ggctgtattc taatttatcg aggcggatga
    14881 caaaggctcg ctatagcaat aactaatgta ggaatgaagg atatcgagaa gatagacatg
    14941 atgcccaaac gccacgctgc attaacaacc agatgaggag tatcatgtgc agaagtacag
    15001 aatgatgaaa aatatcactg cgaagtcggc ttcttcctag gcgaactgac gttcaagacc
    15061 tgtcgcatgc ggcgtaactt ggcccaccat tcccggtcac tggccttttt aacttctggg
    15121 ttcacatcgt ccaccacggg ctcatccgtg gatggtacct cagagacagc acgactgtct
    15181 cccgaggtgg tcgaccgatt cagtcgacga tggcgcacat tgagtgcctg gcccagcagc
    15241 tcccagccgg aacgtaggcc ttctagtttc tcggtggccc gtcctgttcc actctgagcc
    15301 ttcccattca cccaaggaca gtagtccata tgctcgttca ccacttccaa agagtcgtaa
    15361 agagcctcat ccccgttggc ctttggtttg tacatccaca ggcccaatct ccggaagcac
    15421 acgctacagc cgaccaaacc agctgtcccg tccgggacag agtcccagcc gaagaatgcc
    15481 aatatgaaag cgttcctagg aacaaacggc tcaggctcag agttatgtgc gttctctttc
    15541 ccgttttcac cctcagtgtt gttctcaatg ctttccatgc gcgtactttc tccggggccg
    15601 ttaaagctcg ctggaagtat cttaatgagt gcttcgatat cgaaggactc gggcgtgtgg
    15661 atgacgtctg ctgccggcaa ttgatcggcc atcttgatga ggtttgagta tcgcttttcg
    15721 aggccagaaa tggctatgtc ggggtttgct agcggcaatc gatgaatagt agctgtaaca
    15781 atcagctcac gaaatggcaa ccacaaatat cagaaaacac accatcacag cccttgttcc
    15841 tccatggaca agtctctccg tgccccttga ccagtcgttc cacgtattca tctacaagct
    15901 tggctcctga tttacattag aagcacgaag cagacacggc aattggaaaa ctcacgaact
    15961 tccttcctct cttgcacctt gtcggcatcg aacccatcca actcgtccag ctcatccgga
    16021 agcttgacaa caaccgaccc accacagttc ccagcacatg ttacccgggc cacatccgta
    16081 catacccagc cgcgcttggc ccattctacc tcactaattg ctgacggttt gggtgcccat
    16141 ctgtcgacgc gacgaaaggt ttccaatcgc tcgagaaaac gttcgcgatc ccaaggaaca
    16201 aagctcggtc gcgaggttga cgataccgaa gagtctctgg agctggggcg tgcgaccttt
    16261 agaagtgaat ttcgtgcaag tgagaagttg ggcgcatcta gacgggcttt cttcttcgat
    16321 gcgtctcgag ctgttgtagg cgcttcggcg gtggctgatt ttgttgagtc ggaggttgac
    16381 ggtttggtta gggactcgag aactcgatga aacttgcgct tcttcgtttc aacggcgtag
    16441 gacattttcc agcacgcgga ggtaatggcg ttgtgcagtt ggagtggtct ttgagataag
    16501 ggagtctgga tcttggaatg gcctcggagc tggtggcgct agacccgaaa tggagctaaa
    16561 tatgtttctg cctaaggcaa cgatagggat gttcacctgc aggtgaatcg ccaggaacta
    16621 cggaattaga tcacatatct tttcttgaca tccaattgtg tccgagcagc atcaggtact
    16681 actttttctt tcttatttgt gtacaattat gtggctgagt ccacttagga catcggaaac
    16741 ggggcaaggt tgatcgtatc tatcaggatc tctacatccc cggaaaaagg tcatctctgc
    16801 gaggaatgaa agggatgttt tcttgcaggc agcagagcgg gtgcctagct gtatgaactg
    16861 ttctatatag ttatttagtt cattgtctgt ctgacctgag ttctatacca attcacactt
    16921 gtcatcaggc attctttatg ataaagacca tcgtggatgc tactttgtcc agaaatctgc
    16981 aacttacttc tatgattact tccttataac ccttctacta ttttattgac ttgttcattt
    17041 atctgtggct tcccccggtc ctggacaatt catatcagcc aagtggcgat agaaggtatc
    17101 acctacggag cgcctagaat ctccaaaaat tattagctta catttgtcca tactgacagt
    17161 ttgtcacatt gtacaacctg gaaatggctc tgaacaatga gcaccttaat atttcagccg
    17221 ttcagcgtgc gcttgcgatt cccgaaatct tgagtcaggt cttcgcgtgc ttctattcat
    17281 acgacaaacg atcgtgtagt caactccttt cttgcgccct cgtcagcaaa ttatggttct
    17341 cagaggcaat gcgttggcta tggagaaatc ccatgccctg tcattcccca agtacttgta
    17401 gggatgttct ggacctcctt gataaaatcc cagaagcacg ccggaatata tacgcaacat
    17461 acatcaagat cgctacactg aaagactatt gccgcaaacc tgatggctta gacactgtcc
    17521 agttcccaag tttacaacaa gtacggatct ggaaattttg ggatcctttc aatttcgagg
    17581 agattaaatt tcagaacaat agcgttcgaa caatttgcac tatcgtgcat tgtcactcag
    17641 acgccgaggg ccacgccaca gcacattttg aaagatacat tactccgctt caggtatgta
    17701 attccaatgc gttcaggggg aaccctttct aatttagtca gtcacatttc aatcatctcc
    17761 gggagtggca cattcttgca ggttccggga taaattcatt cgtaatcttc agattcactc
    17821 aaggcatcga gggacagggc tgggaagggt tcaattgtac ctacagagga cgtttacttg
    17881 aaactcagag tacagaagta aagctcgagt aagaggagag gagtttactc atcagcagac
    17941 tatagaggct ttccccgcaa ttatgctgct ttactcgtac agagagcagc gatatgaaga
    18001 gcatgcgaac gcattttctt accataatca aatagtagaa ttcaatgact attcaagagg
    18061 ccaagcagtc tcatcctctt aaggcttgcg atagtcccta accgagaccg agcaagaccc
    18121 ttattataca gaaagtgggc ttcatcgcag ctaaaatcac ttctgcatct atcaggacat
    18181 gcgcggagtc taataactag tagacagtaa acgattgaga acgacggcaa gaaaacaatg
    18241 ccatatcaca tatgatttag tagtatatgg aatggacgaa tactgataca acttaattct
    18301 tagggtgaag ctgatttgcg gggcctgaaa catacaacta tggtctagga acagtcagta
    18361 atcagaattg tatcatccag tgctctatat acccaggcct gtaacagggt ttagcgagag
    18421 actgtactgc tatgccagga atggaaagct cgtatcccac cacaagtcac gactcgtcag
    18481 ctcctttctt gccctagtct cagcttagct agccccaaaa cgaataacta taaatgcatc
    18541 gcttatcctc caccagacag accccattac tctcctatac attcacacct caagatattc
    18601 atttagtttc tacatctcaa ttctgtatcc atccacatca agcatcacca atcccacgca
    18661 aactcacatc ccacaatgtc atccccaacc atctacctca tcaccggggc cagcagaggt
    18721 acacaccact tttcttattc tcatccccat accacaccac cctcttcgtc cagcttaccc
    18781 acaaaataat ccagggattg gcctcgccct cacccaaact ctcctgctcc tcccaaacac
    18841 cactgtgatc gctaccatgc gcaaccccac cacgaactct ctctatacta accccccacc
    18901 aacatccccc acctcaaccc tcatcctcct tcccctcgac atccaatcca ccacctcaat
    18961 tactacagcc atcgaaaccc tcaaatcgaa acacaacatc acgcacatcg acaccgtgat
    19021 ttccaacgca gggtactaca acgacgccac ccaccgcgtc gacaacatcc ctctctctac
    19081 tgtgcaatcg cacttggacg tgaacacgct tggcacaatc cgcctcttcc agggtgtgta
    19141 tgacatgctg aagaagagca cgaagccgat gtttgtcagt gttagtagct tcctggggag
    19201 tatcggcggt ctcgaggagg aattctttcc cggggctgca tacggggtta gtaaggctgc
    19261 cagtaactgg gtgacgagga aaatgcatgt tgagaatgag gagatggttt gtttcatggt
    19321 tcatccgggg tgagcttact atcttgtgct taggaggttg gggtactgat atgaaatgcg
    19381 taggttcgtc aagactgaga tggggaatgc gtgtgcgaag agtattgggt tggaagaggc
    19441 gtttgcggag ccgaaggagt gtgcggaggc tttggtgaag ttggtaagtc tatattctta
    19501 tttgtacttc ttatatattg gggtgtgata ctgagtagac tagattgcaa gcgccacgag
    19561 ggaaacagtc ggaggtcggt tcatcagttg gagaggggaa gaggttcctt tctaattggt
    19621 agagatatag gaggctgcta ggagattgca tgttgcgctt gttagtagag tatactagag
    19681 cctttaacac atgacctgat gagcttgttc tctatctgtc ctataaaaag ccctatcatc
    19741 ttccccctcg acccataatg ctctctagag ataggcgtat tattcactca tcccagcata
    19801 acgactcctc ggatcccttc tatcccgtat gcgcactcac gtcccctact aaccaatcgc
    19861 ccccatcgtg tatcatttca tcctaaactc cggatcctct ccggagttaa cccccttaac
    19921 cccgatatac ctcgaagata ctacatatat aacctcccac catacaccag aaaccaacaa
    19981 gcaacagtcc aaaacaccat actaatccaa tcaaatatcg atcagaagaa gaaactcttc
    20041 caatatgccc ctcatcttcc taaccggcgg aagcggctac ctcggacacg ccatcacaac
    20101 ccacgctcta tccaagaact acaccatcca ctccctctca cgcagtcccg aaagcgacgc
    20161 caaaatcacc tccctcggcg ccgttccgat ccgtggtgat ctcaccacac actccgtcct
    20221 ccgtgagcaa agccaaaaag cagatatagt catccacctg gcggacccca tggcagggaa
    20281 ctacagcctc ccatacgaag aacgcatccg tatcgacgac gaagccgtca ccgccatcgc
    20341 cgagggatta gtgggtacta acaagccact tgttgtgacc tccggatcat tggtagttgc
    20401 tgctacggga acagagacgg acgagaactc ggcactatgg gaggaaggga aggcgctgaa
    20461 tgagcggatt gtctctgaga ggaagaacct gaggtggtgg gaggagaaag gggtaagggt
    20521 tattgtgatt cggttgccgc cgtttgtgta tggacgggga gggagtgggg tggggttgtt
    20581 catggggatg ttttggaatg gtggtgatgg ggggaagaag gaggtgaagg ttgtgaagga
    20641 ggcggaggag gtggttacgt ctgcggtgca tgtcgaggat gcggccgact tgtatttgct
    20701 tgctgcggag agggccggtg ctggggaggt gtttaatggg tgttcggagt ggggagtgac
    20761 gtttggggag ttggggaggg ccatggcgga tgttttgggg gttgaggttg ggttggttgg
    20821 gtttgaggag gccaaggggg tgtgggggga gttctttgct aggtttttga gtacggagaa
    20881 tagggcttct ggggggaagg cgatgagggt gttggggtgg gcgccgaaga aggttgggat
    20941 tgtggaggag gtgaggcatg ggtcgtatgt tgaggtggcg gagaggttga aaaatggtgc
    21001 tgcgtgaggc tggaagttga cttgggttat gtataaatgt gtttggttgt gtatattgtc
    21061 tgctattaac aagcatgata tcgatatcaa gcgggatttc gaagatctga ttagctatgg
    21121 ac
//
