LOCUS       KZ851964.1             22561 bp    DNA     linear   PLN 20-AUG-2019
DEFINITION  Aspergillus niger.
ACCESSION   KZ851964
VERSION     KZ851964.1
KEYWORDS    .
SOURCE      Aspergillus niger
  ORGANISM  Aspergillus niger
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Eurotiomycetes; Eurotiomycetidae; Eurotiales; Aspergillaceae;
            Aspergillus.
COMMENT     'Annotated using funannotate v1.6.0-df4262f'.
            ##antiSMASH-Data-START##
            Version      :: 5.0.0
            Run date     :: 2020-11-02 07:38:58
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 55725
            Orig. end    :: 78286
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..22561
                     /aStool="rule-based-clusters"
                     /contig_edge="False"
                     /core_location="join{[<65725:66002](+), [66060:66107](+),
                     [66164:66412](+), [66469:67100](+), [67159:67314](+),
                     [67380:67646](+), [67710:67777](+), [67833:67915](+),
                     [67968:68286](+)}"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      join(<10001..10277,10336..10382,10440..10687,10745..11375,
                     11435..11589,11656..11921,11986..12052,12109..12190,
                     12244..12561)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     cand_cluster    1..22561
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..22561
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="1"
                     /rules="(Terpene_synth or Terpene_synth_C or phytoene_synt
                     or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps
                     or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /tool="antismash"
     mRNA            complement(950..2075)
                     /locus_tag="M747DRAFT_159989"
                     /product="hypothetical protein"
     gene            complement(950..2075)
                     /locus_tag="M747DRAFT_159989"
     CDS             complement(1098..1772)
                     /codon_start=1
                     /locus_tag="M747DRAFT_159989"
                     /note="EggNog:ENOG41"
                     /product="hypothetical protein"
                     /protein_id="ncbi_M747DRAFT_159989-T1"
                     /transl_table=1
                     /translation="MAALSRLNGQISTFLAVGFLASWVITALSLTAINVLNTEATFTAQ
                     AASVSLLTFLVCRLLVRLQPVAPTEGRTIAHLLATADYGSRHGSLILVSFCSTWLYELL
                     TKGVLLLLLTFFGGVMATVIYNDPNFSENWQAEPLADQTQTTTALAEIDEFKEKAGFDP
                     TQLFRWIPPQAIVYFIALVWLNFISLGLYILGHGLKALCRVLGFTVTRNTSKDDRTVEG
                     RS"
     mRNA            join(3324..3755,3824..5828)
                     /locus_tag="M747DRAFT_300042"
                     /product="MIP transporter"
     gene            3324..5828
                     /locus_tag="M747DRAFT_300042"
     CDS             join(3720..3755,3824..5641)
                     /codon_start=1
                     /db_xref="InterPro:IPR000425"
                     /db_xref="InterPro:IPR023271"
                     /db_xref="PFAM:PF00230"
                     /locus_tag="M747DRAFT_300042"
                     /note="GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0015267 - channel activity [Evidence IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /product="MIP transporter"
                     /protein_id="ncbi_M747DRAFT_300042-T1"
                     /transl_table=1
                     /translation="MDDGETRRPRATSDAISPRGENPPTSPLSPTRGRRGTAGDADFVS
                     PTRRVSGRDGSGAGVRRRSSAASRRSGGSGIPSLAPRTTLAERTQGRFTMAGPEETPQL
                     RLAHEPFVQPGYGDLNPSYEQPANSKPVWGLAKPLPRVVRPGMVPTKEELLEARQNIQL
                     PAENSQKLGLEVDPNDLELGQIEKTADPRKMAAQVEDARIQRENNFMNKILSGDATTTR
                     QGSRLSRTSSSRIRRPSAWDLPPENLSTVPEGETPAPSETHEEPPQMSSEEPLEPVLEE
                     PELRADDGKDGMMDDLPNLEEIEAAYPEDLHPLVQELVEEEVHNNHTTWSVIRTHHREA
                     LAESLGVFVQLFVGFCGDLAVTVANAGNPNTTDWVWGFATMMAIYVSGGVSGAHLNPTI
                     TIMLWFYRGFPKSKMPEYFAAQFLGAFIAALAAYGLYYHSIQHYLLTNSTTGIITSFVT
                     SQRETWIGPGTAFFTEFLGTMILTVVVLALGDDQNAPPGAGMNSLIVGLMVTCNTMSFA
                     YQTGAALNPSRDFGPRLALLALGYGSSLFTNPYWFYGPWAGSLAGSFLGAFLYDFMIFT
                     GGESPVNYPWERTQRAMRKSRMKWGKRLHLSHRDRGEKTVR"
     mRNA            6124..7843
                     /locus_tag="M747DRAFT_300043"
                     /product="C4-dicarboxylate transporter/malic acid transport
                     protein"
     gene            6124..7843
                     /locus_tag="M747DRAFT_300043"
     CDS             6375..7529
                     /codon_start=1
                     /db_xref="InterPro:IPR004695"
                     /db_xref="InterPro:IPR030185"
                     /db_xref="PFAM:PF03595"
                     /locus_tag="M747DRAFT_300043"
                     /note="EggNog:ENOG41; GO_component: GO:0016021 - integral
                     component of membrane [Evidence IEA]; GO_function:
                     GO:0015140 - malate transmembrane transporter activity
                     [Evidence IEA]; GO_process: GO:0055085 - transmembrane
                     transport [Evidence IEA]; GO_process: GO:0071423 - malate
                     transmembrane transport [Evidence IEA]"
                     /product="C4-dicarboxylate transporter/malic acid transport
                     protein"
                     /protein_id="ncbi_M747DRAFT_300043-T1"
                     /transl_table=1
                     /translation="MSQDAEGGYTMSPIRRVTSSVAWGWYAISLSWGGIAVLLHQTPNQ
                     FTGLTTIGTIVFIANLVIYTTVTLCLLFEAVRPQKVPKPLEESPNFAARWLHIKKPQDL
                     YFVPVSLLAFATIIFCTSYYGTPHCGRWLILTLNVFFWVYTGVSLLLSILLGWWIPYTG
                     TNHGDHFAIVNILPYFPPMLSGTMAGVLAPNQDPAQAVPMLVGGTTMQGFGFLMFLVIL
                     VQSLTEISSEGLPVPNFRPEMFIAVGPPSFTIIAMISMADAAVEKLPDHYISAATSVRT
                     ADVLLIVAVVASVFLWLLAFFLFCMAALSMLEALWHRTIRFELIWWCMVFPITGFVLAT
                     IDMGEYLASPAIEWVGSGMTIFQVCLWLTITACQLFKWVYKREF"
     mRNA            complement(join(<7704..8102,8147..8536,8596..8737,
                     8789..>8928))
                     /locus_tag="M747DRAFT_249313"
                     /product="CRAL/TRIO domain-containing protein"
     gene            complement(<7704..>8928)
                     /locus_tag="M747DRAFT_249313"
     CDS             complement(join(<7704..8102,8147..8536,8596..8737,
                     8789..>8928))
                     /codon_start=1
                     /db_xref="InterPro:IPR001251"
                     /db_xref="InterPro:IPR036273"
                     /db_xref="InterPro:IPR036865"
                     /db_xref="PFAM:PF00650"
                     /locus_tag="M747DRAFT_249313"
                     /note="EggNog:ENOG41"
                     /product="CRAL/TRIO domain-containing protein"
                     /protein_id="ncbi_M747DRAFT_249313-T1"
                     /transl_table=1
                     /translation="MGELAPDQSTVLETFRSCCAAEGLLGRREGLQAGDVVDGINDNTT
                     LLRYLGARRMDPKAALKQLQEATQFQADRQVLRLYDLISVEHYEETRKLYPHWTGRRDR
                     RGRPILVLDLAHLNASTMAAWRKTRDISRNTELTASGTIIPDMEQRAAIYFDSITRFVL
                     PLCSAMSDRPDPTTPIDKSMYIVDASALSLKQAWDLREFARDISWILSTCYPETIDRII
                     VRLGNAPFYFAKIWAFMKNFVDPITADKLVITRPADAYATMAEHMDHKDIPSQFGGGFQ
                     FTNGMLPDLDEGIQQALQWTSSSKEALPQGPLKWTEDENGQRRAVATGSIDGRQRSEEV
                     AILPVNPTTLPSELPN"
     CDS             join(<10001..10277,10336..10382,10440..10687,10745..11375,
                     11435..11589,11656..11921,11986..12052,12109..12190,
                     12244..12561)
                     /codon_start=1
                     /db_xref="InterPro:IPR000092"
                     /db_xref="InterPro:IPR008949"
                     /db_xref="InterPro:IPR033749"
                     /db_xref="PFAM:PF00348"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: Terpene_synth_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182:Polyprenyl synthetase (Score: 237.2; E-value:
                     3.6e-72)"
                     /gene_kind="biosynthetic"
                     /locus_tag="M747DRAFT_326724"
                     /note="GO_process: GO:0008299 - isoprenoid biosynthetic
                     process [Evidence IEA]"
                     /product="geranylgeranyl pyrophosphate synthase"
                     /protein_id="ncbi_M747DRAFT_326724-T1"
                     /sec_met_domain="Terpene_synth_C (E-value: 2.9e-08,
                     bitscore: 25.1, seeds: 87, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MAFTGSFSDDYSDPVPRTCPDIQGFCENYALRRHKFEDWANAGSQ
                     QCRDDWEQYIGPIERWGCCNPWEGHFSAVVLPFCRPDRIAIISYCFEYAFMYDNVVESS
                     AKSTVNNNTDDIALDETEYRTVRSVTGTKQIQSKMLLDLLSIDPACAEVVIDSWKTMIN
                     TTAKQDKTRACSNLEEYVDYRIVDTGAPFVDTLMRFGMDILLTPEEEELVAPIVKPCYA
                     ALGLANDYFSSDIEWEEFQSSESSQTAMTNAVWLFMQWHQVGKEEAKRLVRQVTNDYER
                     EYQQRVQEYIAGEGKSNSKIQLYLTALGYQIPGNVTWSLRCPRYHPWLCEEGSALLQTS
                     MEEARDLPNVGKRRSVSEVSLSSESSVWSGTSDRSARSSVSSAPSLDDREKERDRVTLG
                     TEHLLAPAEYIASLPSKGVREAFIDALNVWLALPDRFVSVMKSIAKTLHNASLMLDDIE
                     DGSPLRRGQPATHTVFGQALTINSANFVLIQAMDQVRLLEDSRCLDIFVEETRNLFIGQ
                     SFDLYWTRQDECPSEEEYLEMIRQKTGGLFRLLARLMMQKATSKKNRCLPLEPLVDLMG
                     EYFQIRDDYKNLAEEYTGQKGFCEDLDEGKFSFPLIHAHKFLPETSDIRNILKQGRRSA
                     GLGIAQKQRVLGWLHESGSMTYTERTLRSLMSEIRHQIDGMEKKSGCPNWVLKLLVHRL
                     EV"
     mRNA            join(<10001..10277,10336..10382,10440..10687,10745..11375,
                     11435..11589,11656..11921,11986..12052,12109..12190,
                     12244..12685)
                     /locus_tag="M747DRAFT_326724"
                     /product="geranylgeranyl pyrophosphate synthase"
     gene            <10001..12685
                     /locus_tag="M747DRAFT_326724"
     mRNA            join(<13298..13588,13673..13724,14059..>14378)
                     /locus_tag="M747DRAFT_362634"
                     /product="hypothetical protein"
     gene            <13298..>14378
                     /locus_tag="M747DRAFT_362634"
     CDS             join(<13298..13588,13673..13724,14059..>14378)
                     /codon_start=1
                     /locus_tag="M747DRAFT_362634"
                     /product="hypothetical protein"
                     /protein_id="ncbi_M747DRAFT_362634-T1"
                     /transl_table=1
                     /translation="MAAHEACSLMGPSIVPNTKGRETTSSSISTVSRYPGLSGNYRGGR
                     TAGAACYSCSRGGSIRVATKRLKAHQQYNAVITGQSKSLVYYQLYIRSFCGRLASSHPN
                     VHVLCKPVGVAVGRVIIRNTQAVCRYLRRTKEHIFIWAWWAGFPGSTPFCLRLQSHQSS
                     ANSLPSPVYLSRSYSSIDLFSPSLLVDHSVSIARGVRSRSIPWCIGHNQGAYGCVQD"
     mRNA            14394..16171
                     /locus_tag="M747DRAFT_300048"
                     /product="hypothetical protein"
     gene            14394..16171
                     /locus_tag="M747DRAFT_300048"
     CDS             14474..15964
                     /codon_start=1
                     /locus_tag="M747DRAFT_300048"
                     /note="SECRETED:SignalP(1-20); EggNog:ENOG41"
                     /product="hypothetical protein"
                     /protein_id="ncbi_M747DRAFT_300048-T1"
                     /transl_table=1
                     /translation="MIYTFSFVLFLSSWIPYSQGSLVAPSIDTSGQNATSVKAANETAS
                     SGLHRQGWTSQPSGRGTLDIIWACCFTMFLCSWSTLCINVPAPGDSSFKIFRRKLYLSA
                     LALLGPEFIFQIALSQWESACKSVKDFEASGIKGWTMTHAFYADMGGYVLKPRDWCQFP
                     INAGQLHYLVTKGYISPPSLDVSIIRDRNKVDGMLRIITVWQTLWFIITTAERAAQDLA
                     ITTFELTTAGFIVCSFATTICWYHKPADIQVSEVIETDVTIEQILLEAEGHPGRPFSRT
                     PLDFITRKEWAWSLYWSNWTNILRKMRIVIFLSGRPVNRFQNTVVPEPSKLGYAMFLLL
                     SAIYSAIFICGWNYSFPTPAEQTLWRVSTVAVFCCVPLFWAVGSFAFSFWPSIASSHKS
                     SSTMESGAIMVPTSAHSSFWLSVKSRASRIANRIRNNSRERDPELTVPLKAILPIYVLG
                     VVYCHARAYIFLEDFIELRSLPASAYATVDWTNIFPHF"
     mRNA            complement(join(16088..16171,16251..17540))
                     /locus_tag="M747DRAFT_160105"
                     /product="2-heptaprenyl-1,4-naphthoquinone
                     methyltransferase"
     gene            complement(16088..17540)
                     /locus_tag="M747DRAFT_160105"
     CDS             complement(16291..17205)
                     /NRPS_PKS="Domain: oMT (53-172). E-value: 2.2e-18. Score:
                     57.2. Matches aSDomain:
                     nrpspksdomains_M747DRAFT_160105_oMT.1"
                     /NRPS_PKS="type: other"
                     /codon_start=1
                     /db_xref="InterPro:IPR025714"
                     /db_xref="InterPro:IPR029063"
                     /db_xref="PFAM:PF01209"
                     /db_xref="PFAM:PF07021"
                     /db_xref="PFAM:PF08241"
                     /db_xref="PFAM:PF08242"
                     /db_xref="PFAM:PF13489"
                     /db_xref="PFAM:PF13649"
                     /db_xref="PFAM:PF13847"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089:methyltransferase (Score: 132.5; E-value:
                     2.9e-40)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="M747DRAFT_160105"
                     /note="EggNog:ENOG41"
                     /product="2-heptaprenyl-1,4-naphthoquinone
                     methyltransferase"
                     /protein_id="ncbi_M747DRAFT_160105-T1"
                     /sec_met_domain="PCMT (E-value: 3.9e-07, bitscore: 21.7,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MSASETEPLIKENAPLVSYYNSLESRIGYRAFLGGTRHFGYYEPG
                     CWWPFPITAALRKMEDHLARSLNLPPGATVLDAGCGYAHVAIHMARKHGLRVTGIDVID
                     RHVTRGKENVRAAGLSNSVSLQKGDYHHLENFADRTFDGLYTMETFVHATDPKAALQEF
                     CRVLAPGGSIALYEYDHINIAGDNITEDMRRQFAQINKYAAMPANISFEQGTLQSLLED
                     AGFIEIQSTDLTENVKPMLRLFFIVAYIPFLLISFFGLEKYFINAVAAVMGYRYLYMHR
                     YICVTARKPGDRQGLDGEVKKAI"
     aSDomain        complement(16690..17046)
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_M747DRAFT_160105_oMT.1"
                     /domain_subtype="oMT"
                     /evalue="2.20E-18"
                     /label="M747DRAFT_160105_oMT.1"
                     /locus_tag="M747DRAFT_160105"
                     /score="57.2"
                     /tool="antismash"
                     /translation="AALRKMEDHLARSLNLPPGATVLDAGCGYAHVAIHMARKHGLRVT
                     GIDVIDRHVTRGKENVRAAGLSNSVSLQKGDYHHLENFADRTFDGLYTMETFVHATDPK
                     AALQEFCRVLAPGGSI"
     mRNA            complement(join(<17476..17799,17895..17977,18075..18183,
                     18426..18470,18690..>18743))
                     /locus_tag="M747DRAFT_319436"
                     /product="hypothetical protein"
     gene            complement(<17476..>18743)
                     /locus_tag="M747DRAFT_319436"
     CDS             complement(join(<17476..17799,17895..17977,18075..18183,
                     18426..18470,18690..>18743))
                     /codon_start=1
                     /locus_tag="M747DRAFT_319436"
                     /product="hypothetical protein"
                     /protein_id="ncbi_M747DRAFT_319436-T1"
                     /transl_table=1
                     /translation="MMLGPDGKVSDIRQYSLWATVFEHHQPASKLRKRLNKPPADGHTA
                     YPNKHYQRLGRDRSRVTFAESRPTGECSSPSWELMAGRTSCRAPADDPEVDTISRGIKL
                     GWPSHWISVSFALPPPRTTAKWHFNQSIIYANSGFGPEQPGHRASETCRLCPKVRTGGA
                     SSLEGKSGPMTGLDTSTAQASGLKTSFHWVGGQLAKRFSPH"
     mRNA            join(<19021..19108,19155..19595,19659..>19867)
                     /locus_tag="M747DRAFT_319437"
                     /product="dienelactone hydrolase family protein"
     gene            <19021..>19867
                     /locus_tag="M747DRAFT_319437"
     CDS             join(<19021..19108,19155..19595,19659..>19867)
                     /codon_start=1
                     /db_xref="InterPro:IPR002925"
                     /db_xref="InterPro:IPR029058"
                     /db_xref="PFAM:PF01738"
                     /locus_tag="M747DRAFT_319437"
                     /note="EggNog:ENOG41; GO_function: GO:0016787 - hydrolase
                     activity [Evidence IEA]"
                     /product="dienelactone hydrolase family protein"
                     /protein_id="ncbi_M747DRAFT_319437-T1"
                     /transl_table=1
                     /translation="MVSNAPSQCCMVGHLHEGRARGEVRQIADISTYIVYPTDRSTKNA
                     ILFFTDGNGHRFINAHLMADQFAARGYLVVMPDLFHGDPIPIDYGPDFDIMGWYNQHLP
                     PRVDPIVDAMLGQMRSTLGCQRVGAVGYCFGGKYVCRYLKAGKLNAGFMAHPTMVQVGE
                     LEGVEGPLSIAAAIVDPVFTTANRHESEAILARLGVPFQINLFSDVEHGFAVRCNLAEP
                     QQKFAKEAAFEQAVAWFDRYVKE"
ORIGIN
        1 agggatcgcc tgcgacatgg acaccatcct ggacattgcc agtcggcatg acctgctcgt
       61 ggttgaggat gccgctatgg cctgcggcag cacgtatcga ggacgcgcgc ttggaaccat
      121 agggcacctt ggctgcatca gtttccaaga gaagaaagta ttcactagtg aaggtcaggg
      181 aggggcatta ctcgtcaacc gggactcact cgtcgcgcgg gctgaaatcc tctatgaaca
      241 cggcacgaac cgagctcagt tcctgcgtgg cgaagtggat atctatcgct ggctggatgt
      301 cgggattaac gcaaccctga gcgagattca agcagccttc ctatatgccc agttgcaagc
      361 cgcgccgcag attctttcat gccgccgacg tctctggtct cgctatcaca gatgcctggc
      421 ccctttggcc gacgcgggtg tcatctgttt accccaaccg gctgcggagg cggaccataa
      481 cgcagccgtc ttctggcttc ggttgactga cgccacaaac cgatctgcat tcattgagca
      541 tatggcggcc ggacaaattc agacacaggc acagttcgtg ccgctacact cttctccatt
      601 cggcgaacgg ttcgggcgtt ttcatggcga ggatcgggtg actacacgcg ccgcagcgga
      661 gattgtcttg ctaccacttt acgcggggct cacagaatgt caacaggaaa ttgtcattcg
      721 gcgcgtgtta gggttctggc aggaagccac aagcaccccg agaacggaag cttcccgcga
      781 tgctgaagtg aataattctt aggcaatgat ttgcatctgg aaatctacct atcagtgctt
      841 tcctcatccc ttcggagcag aaggggcgcg ctgcgagcag caatggtgag cctagtttag
      901 tcaagccgtc acaatgaata tattttgcgg atacgaagag gatagaacac ctgagacggt
      961 gctaggatag gataggaatt gcaatcgtaa tatgtggttg agtaaatcat gctgtacatt
     1021 tgacactagt cttgacgatg cctgtcgggc tgtttataca cggagtatcc cctaatccaa
     1081 tatggcatgg ggcaagctca ggagcgccct tccaccgtac ggtcatcttt gctcgtgttg
     1141 cgcgtaacag taaagcctaa gaccctacaa agcgccttca gtccatggcc gagaatgtac
     1201 agccccagac tgatgaagtt aagccacact agggcgatga agtagacgat tgcctgaggt
     1261 gggatccatc gaaataactg cgtcggatcg aagccagcct tttccttgaa ctcatcaatt
     1321 tcagccagcg ccgttgtcgt ttgggtctgg tcggctagcg gctctgcctg ccagttttcc
     1381 gagaagttag ggtcgttgta gattacggtc gccatgacgc cgccaaagaa ggtcaacaga
     1441 agcaggagga cgcctttggt cagcagctcg tacagccatg tgctgcagaa ggagacgaga
     1501 atgagcgagc catgtcggga accgtagtct gctgttgcaa ggagatgcgc gatggttctc
     1561 ccctcggtgg gagcgacagg ctgaaggcgg accagcaatc ggcacacgag gaaggtgagc
     1621 aagctgacgg aggcagcttg cgcggtgaaa gtggcttcag tattgagaac attgatagcg
     1681 gtcaaactca aagcggtaat gacccacgag gctagaaagc caacagcgag aaaggtggag
     1741 atctgcccat tgaggcggga gagggcagcc atggcaggtc aaacagcgaa actcgcgggt
     1801 ggtatggtgg tgttgaacgt ttctcaagct ctgcaaccgg aaattccgag ttttatattc
     1861 tacaggtgat gctgggcgag ccgatttaaa atctttggac ccttgggtcc tggatgagcc
     1921 gaacagcgat agtgttgaca gggtcatcac ctattcccga aagagtcgag gacgaggcta
     1981 ttccaggcct aatatggaag gcggacgctg ctcggctgag acacgcccca ctgttcgtct
     2041 ttcatcttct gtcagggtgg aaaccctttc atctccaggt atctggctag gtagatatct
     2101 agtggtaggc agacacggtt gcctgttagg atctctaatg aggtagcacg gtttcagcct
     2161 ctcgcagtga gtcaacagtg agcagccaaa agttttcaca ctaagtttgc gatagtggag
     2221 cgtccgagga cgtcactgag agtgaatact atataagaga aataggaggt tacttttcct
     2281 cttcctcaca aagaggttat gcaggatccg ttgggttccg agtgatcctc aacagtagtc
     2341 attttctgtt gcgccgggaa gaatctcctc tctaacagat ggaagaaagg aactgcatca
     2401 acatgagtct agtcacgatg tcttcatgtg cctatgtaga aatttccaga gatgcattat
     2461 atagtacaat gagaacgtgt ctcgcgttct cttggggttc cctcatccct ttgcaaactc
     2521 ttcgcggaag tctcggatag actccttgcc aagacatttc catggccccg aacaaaaggc
     2581 tgaaattact gatcaaaggg tgcgattact accagcatag atgctgacta ggattctcag
     2641 agggtaaaaa cccagcaaac accgagaatt gctgttatct ccctctactt gggttttctc
     2701 tcgcgataag tctttcctca ccggcaatcc acccctcagc attgattcta tccgtaatct
     2761 gccgagtatc ggggaatcct cggaagacac aatggatcga atgggattgg attgtgtccg
     2821 gagactaagg agcaagaatc aaggaacggc gcaatcgtgc cggccggttc ccttgtggct
     2881 gattccacgc acgttccatc caccacgaac catattgcac aattctatca aatctccatc
     2941 gcgcagctaa aatagtactg tactggatgt ccactggaca caataatggc cctgacaccc
     3001 gaccaccggc tgaagcaaaa atctttgcat cttttttagt ccttctcacg ccagctcccc
     3061 gatcgatcga tgaggagggg ttatcgccat tcagggccca ataactcacg atgatcggtg
     3121 acgatgacca cagaggaccg tcattgagcg gggatgtata gtgggttata ccgcggacca
     3181 gggccaacca gcgaagcatt tgggggatca ggccaggaac caaaccctgt tgcgtgtcga
     3241 ttcctttgcc tctcaagctt tccgacaagc cccatgagga tccacccatg acgccagtct
     3301 ttcccatgtc ttcaacgctc cccgatagtc tgcccgcacc accgcaaccc actggcctgt
     3361 actttttgta gatctcgcgc atcaatgctc aatggccggt gtggatgcgc tcgcttacgc
     3421 cctcgctgca gtctctggtc cagtcggaga tgcggagagg gcgccagcaa gtcgtcatca
     3481 tgtttgctgc tccttcacgc cattctttct tctcctgtct ttaattgttc ccctactcct
     3541 gttgctcact ggccaatttt tcaacgtctg gaacatcagc tgggcgtctt gagtgtgtca
     3601 cgcagccatt gcttccagtt gagtcggcca tccgcatccc gtccattatt cgcatcccat
     3661 cgacaggagc aattttatca cccttcgaat aagcacatag catctatctc cgtcacaata
     3721 tggacgacgg ggagaccagg cgcccacggg caacggtatg ttcactcgta ttctccttca
     3781 gctgagccag gagctgatcg gagtaatctc ctcgcttgag cagtctgatg cgatctcccc
     3841 ccgaggagag aaccctccca cttcacctct atcacctact cgcggccgcc gagggactgc
     3901 tggtgacgct gactttgttt ctcccacccg ccgcgtctct ggccgtgatg gctccggggc
     3961 tggagttcgt cgacgcagct ccgccgcctc ccgtcgcagt ggtggaagtg gcatccccag
     4021 tttggcgcca cgcaccacgc tggctgaacg aacccaaggt cgtttcacca tggctggccc
     4081 agaagagacg cctcagctgc gcttggccca tgaaccgttt gtgcaaccgg gctatggcga
     4141 tctaaaccca tcctacgaac agcccgccaa ctccaaacct gtctggggtc tggcgaaacc
     4201 gctccctcgt gtcgtccgac cgggcatggt gccgaccaag gaggagctgt tggaagcccg
     4261 tcaaaatatt cagctgccgg cagaaaattc acagaagcta gggctggagg tcgaccccaa
     4321 tgacctagag ctgggccaaa tcgagaagac ggctgaccct cgtaaaatgg cggcccaggt
     4381 ggaagatgcc cgcatccagc gtgagaacaa cttcatgaac aagattctga gtggggatgc
     4441 caccacaacg cgacaaggct cgcgcctctc gcggacttca tcgtcgcgta tccgccgccc
     4501 atcggcctgg gatctcccgc ctgagaatct ctcgacggtg cccgaaggcg agaccccggc
     4561 tcccagtgag acccatgagg aaccccctca gatgagtagt gaggagccct tggagcccgt
     4621 cctggaggag cccgagctgc gcgctgacga tggcaaggac gggatgatgg acgacctgcc
     4681 caatctggag gagatcgagg ccgcctatcc ggaagatctg catccgctgg tacaggagct
     4741 ggtggaggag gaggtgcaca acaaccacac cacctggtcc gtcatccgca ctcatcaccg
     4801 cgaagccctg gccgagtccc tgggggtctt cgtgcagctg ttcgtcggct tttgcggcga
     4861 tctagcagtg accgtggcca acgccggtaa tcccaacacc accgactggg tctgggggtt
     4921 tgctaccatg atggccatct acgtctccgg tggtgtgtcc ggtgcacatc tcaatccgac
     4981 catcaccatt atgctatggt tttaccgcgg tttccccaag agcaagatgc ccgagtactt
     5041 cgccgcgcaa ttcttggggg ccttcatcgc cgcgctcgcc gcgtacggtc tctactatca
     5101 ctccatccaa cactatctcc tgaccaactc caccacgggc atcatcacca gctttgtgac
     5161 aagtcagcgc gagacctgga tcggtcctgg tactgccttc tttaccgaat tcctgggcac
     5221 gatgatactg actgtggtgg tcctggcgct gggtgacgat caaaacgcac ccccgggagc
     5281 gggtatgaac tcactcatcg tgggtctcat ggtgacctgc aacacgatga gctttgccta
     5341 ccagacgggt gccgccttga atccgagtcg ggactttggg ccccgactgg cgttgctggc
     5401 tctcgggtac ggctcgtcgc tgttcaccaa tccgtactgg ttttacggac catgggccgg
     5461 atcactcgcg ggctccttcc tcggtgcctt cctgtacgac tttatgatct tcacgggtgg
     5521 tgagtcgccg gtcaattacc cctgggaacg gacgcagcgg gcgatgcgca agagtcggat
     5581 gaagtggggg aagcggttgc atctgtcgca ccgagacagg ggagagaaga ctgtgcgttg
     5641 aacaggagcg gcgtagacaa aggggaattc gaatttagtg cagaatgttt caccagattg
     5701 tttgagaatg ccttgctacg tgcatgcggg atgcatacta gtgatgtttg tagttacatg
     5761 atacactcat attgaccgca atgagcgatg aacgttgtac atacccattg atgattcggg
     5821 ttctggataa tatatatata tatatagttc aattactttc ttattatttt tataatcata
     5881 gtagcatccc aactcatggc gaggtagtgc tactacttaa tagccccgcg attggtaact
     5941 tctctcgcct ttattgtgcc agtacttgta tattcccctg cggcaagccg atcggtatcc
     6001 cgaggcaagt atcgggccac ccggaaatcg accgagacgc gggaaggttg acacagtctt
     6061 cttgaccggg tattgttatc tgcaccagtt gttcttgttc tttcatcatc tgcgccgacg
     6121 tgcctggttg agagcgtctc cactgcgact gaaaatgacg tcaccaacca tcgcccccaa
     6181 aaccatcaca ctggatatga tgctcggtga tgcccagaaa aggcaataga cagcagagac
     6241 aaggatacgg aatcttcttc tgagacgccg tataggaaac cgggacttat ttagtcgaag
     6301 gaacccctgc aacctggctg tgattgtagt ccgacccctc cgccctcttg tcaaccgtca
     6361 ccaccgccat cgacatgagc caggatgcag agggaggcta tacaatgtct ccaatacgca
     6421 gggttacctc atcggtagcc tggggctggt atgctatctc actcagctgg ggtgggatag
     6481 cggtgctgct gcaccagacc cctaaccagt tcaccggcct cacgaccatc ggaaccatcg
     6541 tctttatcgc caacctagtc atctatacca cagttaccct ctgtcttctc ttcgaggctg
     6601 tccgaccaca gaaggttccc aagcccttgg aggagtcgcc taactttgcc gcgcggtggc
     6661 tgcatatcaa gaagccccag gacctgtact ttgtccctgt ttcgctgctc gcattcgcga
     6721 ccatcatctt ctgcacctcc tactacggca ctccgcattg tggccgttgg ttgatcctca
     6781 ccctgaacgt cttcttctgg gtctacaccg gagtgtcgct gctgctgtcg attctcttgg
     6841 gctggtggat cccgtataca gggaccaatc atggcgacca cttcgccatt gtgaacatcc
     6901 taccctactt tccacccatg ctcagtggca ccatggccgg cgtcttggcc ccaaaccagg
     6961 accctgctca ggccgtcccc atgctggtag gtggcaccac catgcaagga ttcggattcc
     7021 tcatgttcct ggtcattttg gtacagagcc tgacggagat ctccagcgag ggtctcccag
     7081 tgccaaattt ccgaccggag atgttcatcg cagtgggtcc gcccagcttt acaattatcg
     7141 ccatgatcag catggcggat gcggcggttg agaaactccc agaccactat atcagcgctg
     7201 caaccagtgt gcgcactgcg gatgtcctgc tgattgttgc tgtggtcgcg tcggtcttct
     7261 tatggctctt ggccttcttt ctgttctgca tggcggcact gagcatgttg gaggctctgt
     7321 ggcaccgcac cattcgcttc gagcttatct ggtggtgcat ggtcttcccc atcacaggtt
     7381 ttgtgctcgc caccatcgac atgggcgagt atttggcttc accggcaatc gagtgggttg
     7441 ggagcgggat gaccatcttt caagtgtgtt tgtggttgac tatcactgcc tgccagctat
     7501 ttaaatgggt gtataagagg gagttttagc ttcatcatgc ggcatatacc ccggacggag
     7561 tggttattgc tcactagaga ggagagagaa ataaagcggc atagctggct atttcctagt
     7621 catttgcggt tgctatatcc tttagagaat tttaataaca acgtcatgtt ctatatcata
     7681 tacgccggaa atatgccatg ccatcaattc ggcagttcgg aaggtaaagt ggtggggttg
     7741 actgggagga ttgcaacttc ctcacttctt tgccggccat caatacttcc tgttgccacg
     7801 gcccttcgct gtccattctc gtcttcggtc cacttgagtg gcccttgcgg gagtgcctcc
     7861 ttactggagc tggtccattg tagagcctgc tgaatcccct catccaggtc cggcagcatc
     7921 ccattggtga actggaaacc tcctccgaac tggcttggaa tgtccttgtg gtccatgtgt
     7981 tccgccatgg tcgcgtatgc atccgcgggc ctggtgatca ccagcttgtc agccgttatg
     8041 gggtcgacaa agttcttcat aaaagcccat atcttggcga agtagaaggg cgcattgccc
     8101 aactaagaga tgagttaaca tcaataccaa gtcacggtgt aagcaccctt acaatgattc
     8161 gatcaatagt ctccggatag caggtcgaga ggatccagct gatatcgcgt gcaaattccc
     8221 gcaaatccca ggcttgcttc agagataggg cggaggcatc gacgatgtac atggatttgt
     8281 cgatgggggt ggtcgggtcg ggacggtcgc tcatggccga gcaaagcggg agcacgaatc
     8341 gagtaatgct gtcaaaatag attgctgcgc gttgttccat atccggaatt atagtacccg
     8401 atgcagttaa ttcagtgttc cttgaaatgt cgcgcgtctt tctccaggct gccatagtgg
     8461 atgcgttcaa atgagcaaga tcgagcacca ggataggtcg ccctcggcgg tcccgtcggc
     8521 ccgtccagtg aggatactgg tcatcgtgtg aattactact actttggttg ccactcgcga
     8581 gatttcccaa cataccagct ttcgcgtctc ctcataatgc tctacggaga tcagatcata
     8641 cagacgaaga acctgtctgt cggcctgaaa ctgggttgcc tcttgcaatt gcttcagagc
     8701 cgcttttgga tccatgcgac gagcccccaa atatcgtcta tatgcgccaa tcagtacagc
     8761 accgatgaat agagggtttt ttgctcacaa aagagtagtg ttgtcgttga tcccatcaac
     8821 aacatctcca gcttgtaacc cctcccgacg ccccaacagg ccttctgcag cacagcaact
     8881 cctgaaggtc tctaggacgg tcgactggtc cggagctaac tctcccatct tgtgatgtga
     8941 aaaggccggg ctccacagat gaggacgatg gaatgcgagg agggtaggaa actgatcaga
     9001 tctatgttgt tgcaggataa tggtgctgat tcagtctctt gtggttgcag tgtgacggcg
     9061 gggttcctgt gctgagtggc tgggggcgcg gctgaaagcg tcacagcctg ctgcaggatg
     9121 tgggatggct agcacattcc caacattgcg atgcaatgtc attcgcctta cgcattgtca
     9181 aacccagctt ccggtacctt tctccgccat cttacccctc tgaatgccgt cgttcggggc
     9241 tttgccaggg ttgttagcgt agtgagagat gaagtttaaa tccatgatat gatgatggct
     9301 tcacctgccg atcttccggt gcccagctct cctcacgaac agccgcaaca ttattggccc
     9361 gggcattgca aaggacccga acttagatga aatgccgaca tcgaatgtct gaaatcaatg
     9421 acttaagctt tgaacctgtt cctcgaatga gccgagcttg gatcatcctt gcaagctttg
     9481 gtacgtactc tgtaatccca tgaggtgatc tgcaccatca acgatcttca agctcgcccc
     9541 aacccaatta gattcgaatg aggaaggctc caagtggatt gaagtggatt ctttcaaccc
     9601 tggcacacct catcgcgacg caacttcggt ggatgattca cagaccccca ctgcccgcaa
     9661 ggggttgatt ggcctatgtc tacaaagatc ctctcgatgg tactatctct ccatcacctt
     9721 cagatcagat tgtccttccc gctcagatga acgcctgttc gcgtgaacag aatctccttg
     9781 ctggcaatgg atgatgttga caattacact atcatgcctc attatggagc tgccagtgct
     9841 ctttccggac aaggggctcg tccgtccata atgatggatt taaagacgac catgtcagtt
     9901 ttggaaaaac tgtcttctct tggctcctca tctttcctgc ataatctgca aagccattgg
     9961 aattgattag cggtcggata tttcttgtct tcagttcatg atggcattta caggttcatt
    10021 ttccgacgat tactccgatc ccgtccctcg gacctgtccg gacattcaag gattctgcga
    10081 aaattatgcc ctgcgacgtc acaaatttga ggattgggcc aacgcaggat cccaacaatg
    10141 ccgagacgat tgggagcagt atatcggccc gatagagcgc tggggatgct gtaatccgtg
    10201 ggagggtcac ttctccgcgg tcgtcttgcc cttttgccgg cccgatcgta ttgccatcat
    10261 cagctactgt ttcgaatgtg agatttcact aactcactgg ggcaaccctc ttttgccaag
    10321 gctcacatga gatagatgca ttcatgtacg ataacgtggt tgaatcatcc gccaaatcca
    10381 cagtatgccc gatagcgaag tttgtcttca gaaagttatt catgtctaac taatgccagg
    10441 tgaacaacaa cacagacgac attgccctcg atgagacgga ataccgaacc gtgcggtcgg
    10501 tcactgggac caaacagatc cagtcaaaaa tgttactcga cctcctgtca atcgaccctg
    10561 catgtgctga ggttgtcatt gactcctgga agacaatgat caacacaacc gcaaagcagg
    10621 acaagacgcg cgcatgcagt aacctggaag aatatgtcga ctaccgtatc gttgacactg
    10681 gagcaccgta agggattatc atgtcgtttc tggcttttcc atggatacct aacagacatt
    10741 atagatttgt ggacacattg atgcgtttcg gaatggacat cctcctcacg cccgaggaag
    10801 aggagcttgt cgctcctatt gtcaagccgt gctatgctgc cctcggactt gccaacgact
    10861 acttctcttc tgatatcgag tgggaagagt ttcaaagttc agaatcaagc cagaccgcca
    10921 tgacaaatgc cgtctggcta ttcatgcaat ggcaccaggt tggcaaagag gaagcgaaaa
    10981 ggctcgttcg gcaagtcaca aatgactacg aaagagagta ccagcaacga gtacaggaat
    11041 atattgccgg cgaagggaag tccaatagta agatccaatt gtacctcact gcattgggat
    11101 accagattcc cggaaatgtc acctggagtc tgcgatgtcc tcggtaccac ccctggttgt
    11161 gtgaggaggg cagtgccctc ttgcaaacgt cgatggagga ggctcgcgac ttgcctaacg
    11221 taggtaaaag acggagtgtc tcagaagtta gtctctcgtc cgagtcctcc gtctggtctg
    11281 gaacaagcga tcgttctgca cgctcatcag tgtcctcggc accttctctc gacgataggg
    11341 aaaaggagcg cgaccgtgtt acgcttggaa cggaggtaag cgcgttgtcg aatataacat
    11401 gttatcaatc aaaggttcct gacagcctac gcagcatctc cttgctccag cagagtatat
    11461 cgcctcactc ccctccaaag gagttcgcga ggctttcatc gacgcgctga atgtgtggct
    11521 tgctctcccg gatcgtttcg taagcgtcat gaaatccatt gcaaagacat tgcataatgc
    11581 ctctttgatg tgagtgctcg aatcaaattc gtgccgtgaa ttccactcta ctaacgaccc
    11641 tgccatcttg tgtaggctgg atgacatcga agatggttcc cctctgcgtc ggggccagcc
    11701 cgcgacacac accgtcttcg gacaggcgct caccatcaac tccgctaact ttgtcctcat
    11761 tcaggcgatg gaccaagtga ggttgttaga ggactcgcgc tgtctcgaca tcttcgtgga
    11821 agagacgcgt aatctgttca tcggtcagag ctttgatctg tactggacac gacaggacga
    11881 gtgtccttca gaggaagaat atctcgagat gatccgccaa agtagtactc acttttctcc
    11941 ctctcagact tttctatcac agattttgtg ctgactaaat agcagaaacc ggtggtctct
    12001 tccggctatt ggctcgatta atgatgcaaa aggcaacatc aaagaagaac cggtaagaag
    12061 cgcgaacgct ttgatggaaa gagtttacta actttcccaa cacaatagat gcctcccgtt
    12121 ggaacctctt gtcgacctta tgggagaata ctttcagatc cgagatgatt acaagaacct
    12181 tgccgaagag gtcagtttac ccacacagaa cgactacaca tgcaagctga cccaaaatcg
    12241 cagtataccg gacaaaaggg cttttgcgag gatctagatg aggggaagtt ctcatttccg
    12301 ctgattcatg ctcataagtt cttgcctgag acctcggaca ttcgaaacat cctcaaacaa
    12361 ggccgccggt cggccggact tgggatcgca cagaagcagc gcgtattggg ctggctccac
    12421 gagagcggaa gcatgacata cacagaaaga acacttcgga gcctgatgag cgaaatccgg
    12481 catcagatcg atgggatgga aaaaaaatcg ggctgcccga actgggtcct gaaactcctc
    12541 gttcaccgac tggaagtctg atattggtta gatggattgg tgaaattcaa cgactgcaat
    12601 gctttgtttg gcgtttattc cgcatgtggg gaggtgactg ttgctatgag atctttgggt
    12661 ggccttgtga attcgaagat ttgtggtata tagaattcta ctgtgtgttc ttacatatga
    12721 agacatgagt acctaaatag atcggccgtt gtgcaagctt tacgtacagg tctaggcggg
    12781 gggtaggctg tgcgatactt ggactgggac acttggcatc ctgattagcc atccagaact
    12841 tcacattagc gtggaaagct cccatgtctg ttccagcctg ccttcctaat acttcgtaat
    12901 tgtgttgtta gtttgacatt tagtccgtct gatcaccagg gtcctttgga aaggctgtct
    12961 cgccttgcca cgtttaggaa ggctaaaaca ttgagtatag atggttcgat ctttctaaat
    13021 ctagtgtcag cgcctaacaa ctggacgggc atgcaagtag gctcaattga cgtttcgcgg
    13081 gttacaggtg aggttcgggc cgcccgcaga ggcttgtgtg agacacagac cttttgagac
    13141 caaagtcacg ccatgccatc cggtcgaccg acttccagag gcagccagta aaagacggaa
    13201 tatcacgcgt agtgcgcggg gtagcacaca ggatcggcca cactaatgca aacactgctc
    13261 cgagacgggc cgctttctgc ctaccagccc gcctaggatg gcggcccacg aagcctgttc
    13321 tctaatgggc ccctctatcg taccaaacac gaagggcaga gaaaccacga gttctagcat
    13381 ttctactgta tcgcgatatc ctggcctttc cgggaactac aggggcgggc gtactgctgg
    13441 tgccgcctgt tactcatgct ccaggggtgg cagcatcaga gttgctacta agcgcctaaa
    13501 agcacaccaa cagtataatg ccgttattac tggccaatca aagtcccttg tatactatca
    13561 gctttatata agatccttct gtggtcgggt aaacccgatg gctctcatcc tagcaatgtg
    13621 acacgctgac ctcaacccat gctttgatcg tatctttccc tggcacatac agttggcgtc
    13681 ctcccatcca aacgtacacg ttctttgcaa accggtaggc gtaggtgaaa gtaccatagc
    13741 ttcaaaactt actgaactcc aatgtatcat cacaggaaat gaataaacat cacccccact
    13801 tgggtcatat agatgggatc ttaatatgcc cttcagtgcg tcacaaagag acctagcata
    13861 tatctcctta tcattacctc tgatacatag cactgctccc gtctccagag aaactaataa
    13921 tgatagctgt gctaattacg cgccctgatt cctcaatcgt tcaacgctat gcttaacact
    13981 atacctaatc gatgtcacgc tagagattta gttgaaacta tgctgcaatg tgaccaccac
    14041 catttacgtg ggcctcagcg gttggacgtg tgattatccg gaacactcag gcagtttgcc
    14101 gttacttgag gcgtaccaaa gagcacatct tcatctgggc ttggtgggct ggctttcccg
    14161 gcagcacacc attttgcctt cgtcttcaaa gccaccagtc gtcggcgaac tctttaccgt
    14221 ctccagtcta tctaagtcgg tcctatagtt ctattgacct gttttcgccc agcttactag
    14281 tagatcattc agtaagtatt gccaggggtg tacgtagtcg atcgattcca tggtgtatcg
    14341 gtcacaatca gggcgcctat ggatgcgtcc aggattaaaa taagtcgccg ccctccaagg
    14401 ctgatatcat atttatacaa aagacttttc tttgcttacc attgctgccc tgatcgttcg
    14461 tgaatttcca atgatgatat acacattcag ctttgttctt tttctatctt catggatacc
    14521 ctattcacaa ggctcacttg ttgctccttc catcgatact tccggtcaaa atgctacctc
    14581 ggtaaaggcg gcgaacgaga cagcttcatc agggctacat cgacaaggat ggacaagtca
    14641 gccatctggt cgagggacac tcgatataat ttgggcttgt tgtttcacta tgttcttatg
    14701 ttcatggtca acattgtgta tcaatgttcc ggcgccagga gattccagct tcaaaatttt
    14761 tcggcgtaag ctctacctga gcgcgttggc tctacttgga cccgagttca tctttcagat
    14821 tgcactttct caatgggaat cagcctgtaa atcagtcaag gattttgagg cttcaggaat
    14881 caagggctgg acaatgacac atgctttcta cgctgatatg gggggttatg tgctcaaacc
    14941 gagggactgg tgtcagttcc caatcaacgc aggccaactg cattacttgg ttacaaaagg
    15001 atacatcagt cccccgagtc tcgacgtgag tatcattagg gaccgaaaca aggtggatgg
    15061 catgctccgg ataatcactg tatggcaaac gttgtggttt ataattacta ctgctgaacg
    15121 cgcagcacaa gacctggcca taactacatt cgagcttacg acggctggct ttatcgtctg
    15181 cagttttgcg accacaatct gttggtacca caaaccagcg gatatccaag tgtccgaggt
    15241 catcgaaacg gatgtaacca tagagcaaat cttgcttgag gcagaaggac atcccgggag
    15301 gccgtttagt cgcacgccat tggattttat tacacggaag gaatgggcct ggtcgctata
    15361 ctggtctaac tggacgaata ttcttcggaa gatgcggatc gtgatctttc tctccggacg
    15421 tcctgtcaac cgcttccaga acactgttgt gccggaaccc tcgaagctcg gctacgctat
    15481 gttccttctc ctctctgcga tctactccgc aatctttatt tgtgggtgga attacagctt
    15541 ccccaccccg gcagaacaaa ccttgtggag ggtctcgaca gtagcagtgt tctgctgtgt
    15601 tcctcttttt tgggcggtcg ggtcatttgc tttctcattc tggccatcca ttgcatcgtc
    15661 acacaagagc tcaagtacga tggaatctgg cgcgattatg gtcccaactt ctgctcattc
    15721 atcattctgg ttgtcggtta agagtcgagc gagccgaatt gcaaaccgca tccgcaataa
    15781 ctcccgtgaa cgagatcctg agctaactgt gcccctgaaa gctatactgc cgatctacgt
    15841 actgggagtg gtatactgcc atgctagagc gtatatcttc ctcgaggatt ttattgaact
    15901 tcgatcgcta ccagcgagcg cttacgctac agtggattgg acaaacatct tccctcattt
    15961 ctaaacgcag tccacccgcg tttgggattc atgtttctct tctattcgat tgttctattc
    16021 ttgctgtgcg aactgtgcga aaactggtgt tcttcaactc gattaccata taatctacta
    16081 ccccttccaa tgcatactcc tttcttggga cactggactt tactatccgc agccacggac
    16141 tactgaggaa tgataaagta tatcacatgt gcttttgtat atatactggt aaatacacct
    16201 tcatagacat atcaaacaca agatcaaagg tggtcgtcgt tcgtacgtac atgtagattc
    16261 aaggggagca tatcggtaac agatccagga ttatatagcc ttcttcacct cgccatctag
    16321 cccttgtcta tccccaggct tccttgcagt aacacatata taccgatgca tataaaggta
    16381 ccggtagccc atgacagccg cgaccgcatt tatgaagtac ttctccaggc cgaagaagga
    16441 tatgagaagg aacgggatgt aggcgacgat aaagaatagt cggagcattg gctttacatt
    16501 ttccgtgagg tccgtggact ggatttcaat gaagccagcg tcttcgagta acgactggag
    16561 cgtcccttgc tcgaaggaaa tattggctgg catcgccgcg tacttattaa tttgcgcaaa
    16621 ctgcctccgc atgtcctcgg ttatattatc tccagcgata ttgatatggt cgtattcgta
    16681 cagggcgata gatccaccgg gtgcgaggac gcgacagaat tcttgcaacg cagctttcgg
    16741 atcggtagcg tgtacaaagg tctccatcgt gtacaagcca tcaaatgtac gatccgcgaa
    16801 attctcgaga tgatgatagt cgcctttttg aaggctgact gaattactta gtccagccgc
    16861 gcggacattt tcttttcctc gggtaacatg acggtcaatc acatcaattc ctgttaccct
    16921 cagaccatgc ttccgcgcca tatggatcgc cacatgtgca tagccgcagc cggcatcaag
    16981 tactgtcgca ccgggcggca gattcaagga tcgggcgagg tgatcctcca tctttcggag
    17041 agctgcggtt atggggaacg gccaccagca gccgggttca taataaccga agtgacgtgt
    17101 accgcctagg aatgctcggt agccaattcg ggattcaagc gaattgtagt aggacaccaa
    17161 tggtgcattt tccttgatga ggggctcggt ttcggaggcg ctcatttttg atgatcaacg
    17221 gccgatttta tagctgggag aagcggacga aggaaggatg tgagaatgac aacggtcgca
    17281 gctcccttta acccccaaac ccggaccacg ccaggtatgc gggcgtgatt aagtaccgcg
    17341 aatcgcatca gcaatgacca agcgctggcg ctaaagatta ggggagtcgg tgttatcaca
    17401 ctaagcccca ttgcaggtgc gtctgtgaca agggtgtgcc tccctcccag acgaatgatg
    17461 tctctggact atgcgctagt gcggggagaa acgctttgct agctggccgc caacccaatg
    17521 gaaggacgtc ttaagcccac tggcttgcgc agtcgaagtg tccaggccag tcattgggcc
    17581 cgacttgccc tcgagagatg aggcacctcc agtacgtact ttaggacaga gccggcaggt
    17641 ctcgctcgcg cggtggccgg gttgttcagg cccgaagcca gaattggcgt agatgattga
    17701 ttgattgaaa tgccattttg cggtggttct aggcggcggg agagcgaaag agaccgaaat
    17761 ccaatgagaa ggccacccca acttaattcc tctgctaatc tggtcaaggc atctccgtaa
    17821 tcacccacaa tcgaagctgc gggatgcgcc acggtgtaaa gagcagcgga agcgggctat
    17881 gcggtatgat cgacggtgtc gacttccgga tcatcagcgg gcgcgcggca gctcgtcctg
    17941 ccggccatta actcccaaga aggggagcta cactcacctg ggcctaaaat aaactgaggc
    18001 cctttgggga ataatttccc tccatttgtc atatcataat cggtcagcca cagcatatat
    18061 acttaggtga caacccgtag gacgagattc tgcaaaggtt acacgactgc ggtcgcgacc
    18121 caaacgctgg tagtgcttat ttgggtatgc cgtgtgacca tccgcgggag gcttattcag
    18181 ccgctgaaag agagagaaac ggcacaatgg cggaccaacc aacaatgggg ctcatttgca
    18241 agtaggtttg taaacaaagc cgaaccgggg cctaagtcca aaaccagaat atgcaggaat
    18301 aaacaaagca aatcggtatg gacctaagaa agtcattggc aaagagaaca aaatatcttt
    18361 cacgtaaagg gtgagcgact caagatatgg accaccgatc acccgtcgcg tctctaacga
    18421 gccaccttgc gcagcttact agcaggttgg tgatgctcaa aaactgttgc ctgcatccat
    18481 ataaatcata cataaactgg gatcgaattt cctataatta aattcgccta ccacaaccgt
    18541 ggacgtctaa tcgatgatct tcagcggatc agggacaaaa aatagccgtt ggagtgctcg
    18601 gatgtccttg cggtgaaagg gacgggagcg agaagaagac agtacatagt tagcagtcac
    18661 ggcacacata gtccaggaca cagtcctacc cacaaactgt attgccggat atcagagacc
    18721 tttccatcag ggcccaacat cataacttca cctctatcga ccaggaaagg cgttgaagat
    18781 gctcgagcag accggctttc ggtggggttt cctgactagc ctatgacgac ccgcccgact
    18841 actgtaagtg acgacagtca actggtgcct ggcaggaagt cgactctgca cctgggtctt
    18901 atcatgctgt aagcggcacc ttggtcctca caatgtagga gggcttgttt cgtctttccc
    18961 ttgaggtttg tgccagaagc tctgctctca ctcttgactg atttgatctg atctctagca
    19021 atggtttcca atgcaccatc tcagtgctgc atggtgggac acctgcacga gggcagggcc
    19081 agaggggagg tccgacaaat tgccgacagt gagcctttgg tgccctacat tcccaagcac
    19141 cactgacttg atagtttcga cgtacatcgt ctatccaacc gatcggtcga caaagaatgc
    19201 catcttgttt ttcaccgacg gcaatggcca ccggttcatc aacgcccatt tgatggcgga
    19261 tcagtttgcc gcccgcggct acctcgtggt catgcctgat ctattccacg gagaccccat
    19321 accaatcgat tatgggcctg acttcgatat tatgggctgg tacaaccaac atctgccacc
    19381 tagggtcgat cccattgtcg atgctatgct ggggcagatg cgcagtaccc tcggctgcca
    19441 gcgagttggc gctgtcggat attgttttgg tggcaaatat gtgtgccgct acctcaaagc
    19501 aggcaaactt aatgcagggt tcatggccca tccaaccatg gtgcaggtgg gggagctgga
    19561 aggggttgaa gggccgttga gtattgcagc tgctagtgag tggaggagaa ctatctcttc
    19621 cctctcccac atatcggtta tactaacagt tacataagtt gttgatcccg tcttcaccac
    19681 tgccaaccgc cacgagagtg aggcgatcct agccagactt ggtgttcctt ttcaaattaa
    19741 tttgttctct gatgttgagc acgggtttgc ggtccgctgc aacttggcag agccccagca
    19801 gaagttcgcc aaagaagcgg catttgagca ggctgtggcg tggttcgatc ggtatgtgaa
    19861 ggaatgagat tcacaagtcg tggagattag tgtcaaagaa gacctcacag tggcgagaaa
    19921 ctccatacgt tatacaccac caaaatccag ggcactagta agaccgtaga cccagtctgc
    19981 tctgaatggt gcctataaat gtgtcatctc ctgtataatc cggcagcttc ggggctccga
    20041 tggcggcacg gaatgatact ttattaggga ttgcaacaga tcctagacac tcctccactg
    20101 atgttctgaa gatttaccct agctctttct ggtgagaaac ccaacttaga caacacataa
    20161 ctccaactac ttattctctg aatcccgccc cgacctgaac cacttaatta tctgcagcat
    20221 cggctttaca atgagcaatg gaggttgtcc accaaaatca ttgccgccaa gcacatgaac
    20281 aaacatacaa cgatcccaaa tagtatgttc atgggcaatt ctattactag atcaagacaa
    20341 cctcaagatt ggccacgaaa gtttgaatct tctgctggtc tcagcgctaa caaggcgcca
    20401 ctaccattag tccaacgaag atggagggag tggcatttat cagccatcac attcgtgcct
    20461 tgcaatcacc tgcctacaaa aggttgctgt ggctaccttc acctcctacc ttggctctgg
    20521 cggtgcccgc ctgaacttcc tgcctttcat cgatgacaag atcgtcttca acaactgcac
    20581 ggcccgctac ctcggtggcc acttaagcaa caagcccgca ccatcctggc cggcggctcc
    20641 aacaatgtca tggcagtttc caatgtcccg tctcctaatc gattgtctat cgccagtcgc
    20701 gaggtctgac cacctaccgc gaccattacc gaggcagctt ctccaacgtg cccctgtccc
    20761 caagtcggcg atcaacaagt tttaatgctc gctggcaaat atacgtcgga ccacgatgct
    20821 ctcttggtgg gtagcaccat tgacggtgcg gttcacgagc tactactcca gttatcttgt
    20881 ctaatggcga tgtcggtgat atccgtgaag taaactgaat ccaggttaag gtgtgcttcc
    20941 gtcaggactt gtcgatattg gtatatgttg agacattcac tacagccggg cagctgtcag
    21001 cttatccttt gcctgtcttc ctgcgtggtc tctgaccacc acctcttcca acgcacaacc
    21061 aaccactctc ttgagatcag atagatcaaa tccctatgtc tttgaccctt cgtcttgaca
    21121 gtatatcatc tgttcaaagt attagaccag cattgatctg aggctcgggt cgactgtaga
    21181 tggtgaaact cctggtagac cgaatctaaa tatctggcat gaattgttat cgcgcgacac
    21241 gctttctaaa agaggttagc cgtccgcgtt gtgctgtgca tatgacaaag tggatgattt
    21301 tgtgaacggg aatgccgtgt cgccccacct tccgctcgca gcatacaagg caactgtggc
    21361 gcaaaggtga tgtaacgtag cattcgcagg gtaagtcctc cattggaccc tgaagtggta
    21421 tcatcctggc taccggggga agccactttc gccaaataga aattcgtgat ccaacaccac
    21481 cagagagact aaaaagatac cttgacggcc aagtgtcctt acggcacggg cgggtatgtc
    21541 ctcggatgat gattgtgctc ccgtcatgtg aaagcggaga tgcggagatg caagagcatg
    21601 cactagtaat gtgagtttta ttcgaggatg tctacttcat ccagtgttta gcttaccagt
    21661 tatcttagaa actgctggct gctgaattta tttgttttct tgaggtgtgt ttattatgcc
    21721 acgctcaaac ggtcccggtt gcggatatat atttccatac tatctaacaa acggcagcac
    21781 tagcactcgt agtaccagtt acttcgtggt cttattgtag catgatacta ctactttacc
    21841 ggtgttactc actgcttgcg aatcaattga aataaatcca catgactcgt aagtacttgt
    21901 cctaggatag ggacaaattc ctcggtagtt tgctcaatta agcaattgat actggctttg
    21961 atccactgaa agcacggcct ggaggaaaga aaccaacaga atcctgttga tatcaacctt
    22021 gagaaaaaat tagtcaagac caggaaaaag tactaggcaa tagctttaat atgttggttt
    22081 ggcgcatata tatgtacgaa tccggtggtg aacaacgaac gcaaaggggt atattaaata
    22141 agagtctatc tataatacaa atctatacat atatacaacc cggtcatgag gaagcagtag
    22201 ctcatgaccc aaattaggca ttattggcgc acgaaaagct gctgccagag ctgtcactag
    22261 agatcgagag gccagagacc cacagaccac agacacagat ggtagcgcca atgccgaaca
    22321 acgccaggtt ggcaagagta aggagcgttt tgcgaaccga ggtgaagtag ttgccccagt
    22381 acatgtacag ccagaagaca ccgggcagac cgactgaaaa attattagtg accgagttca
    22441 atgatgaagt aggaggattc aaactgtatg ggagactcac atgaaaacca actggcaaac
    22501 aatgcgctga ccaagctgac gagatcgcta aagacaggaa tggcctcggc aatcacccag
    22561 g
//
