LOCUS       An03                   21640 bp    DNA     linear   PLN 01-NOV-2020
DEFINITION  Aspergillus niger strain CBS513.88.
ACCESSION   An03
VERSION     An03
KEYWORDS    .
SOURCE      Aspergillus niger
  ORGANISM  Aspergillus niger
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Eurotiomycetes; Eurotiomycetidae; Eurotiales; Aspergillaceae;
            Aspergillus; Aspergillus subgen. Circumdati.
COMMENT     'Annotated using 1.7.4'.
            ##antiSMASH-Data-START##
            Version      :: 5.0.0
            Run date     :: 2020-11-03 02:41:14
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 159722
            Orig. end    :: 181362
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..21640
                     /aStool="rule-based-clusters"
                     /contig_edge="False"
                     /core_location="[169438:172519]"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      9717..12797
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     cand_cluster    1..21640
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..21640
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="2"
                     /rules="(Terpene_synth or Terpene_synth_C or phytoene_synt
                     or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps
                     or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /tool="antismash"
     mRNA            complement(join(1..239,290..515))
                     /locus_tag="CBS51388_002471"
                     /product="hypothetical protein"
     gene            complement(1..515)
                     /locus_tag="CBS51388_002471"
     CDS             complement(join(1..239,290..515))
                     /codon_start=1
                     /locus_tag="CBS51388_002471"
                     /product="hypothetical protein"
                     /protein_id="ncbi_CBS51388_002471-T1"
                     /transl_table=1
                     /translation="MPSFPAPAERAQTLQSLIGYIFNDPNRAMEALVAAGVHMPGLINR
                     TDGHKQLALVGDAVLRMILALDGYEARKGREFTNSILSTKAGNTYIAQAGRNLGLDKLV
                     IVNPAQAGMVADKVMASAVEAIIGAVFMDSDGSVESVRPVLATLGLDWPA"
     mRNA            complement(4546..5721)
                     /locus_tag="CBS51388_002472"
                     /product="hypothetical protein"
     gene            complement(4546..5721)
                     /locus_tag="CBS51388_002472"
     CDS             complement(4546..5721)
                     /codon_start=1
                     /locus_tag="CBS51388_002472"
                     /product="hypothetical protein"
                     /protein_id="ncbi_CBS51388_002472-T1"
                     /transl_table=1
                     /translation="MSIQGFIVAAGFLLGRVAAITPAASSPVASSQAYVPSMSCRTQLG
                     TNSLALVPTTTITRTIHDPTPVVVFSTTQDTVTVTPDASTVTITDYETTTAISTADTVT
                     DTFSTTSTEYDTATVTITPAAVTAIVSVTISTTSTSTSTIASSSGFSPIVETLPTATAA
                     KRSLIEQDDCSSWLDDYQYPQEVECHQKIIVKTTTVSTVAQSPATATAVTPTSTVTVTN
                     TITSTSVVVPSDVSTTLSYSTTSTITETTSAAAETTTVTSTTSAVAAVATTTFYEACGS
                     SNIAGDPLSSEFGSFAGQYMYLIAFTNVPGESLTVGDTSSAYDCCVSCMESSTCAMSYY
                     NAVSSSIRYCYLIHTTTCSQSSVYAKASIHDTSATIQMSNGNCGRVVGIQG"
     assembly_gap    6037..6136
                     /estimated_length=unknown
                     /gap_type="within scaffold"
                     /linkage_evidence="paired-ends"
     mRNA            join(6348..6840,6899..8181)
                     /locus_tag="CBS51388_002473"
                     /product="hypothetical protein"
     gene            6348..8181
                     /locus_tag="CBS51388_002473"
     CDS             join(6348..6840,6899..8181)
                     /codon_start=1
                     /locus_tag="CBS51388_002473"
                     /product="hypothetical protein"
                     /protein_id="ncbi_CBS51388_002473-T1"
                     /transl_table=1
                     /translation="MHTQLFVVCSFFEGSNSYSINHRGTLVECSPLTHYLACKGIANSQ
                     FKTGTQSFSSSPPALELCIPAFTSAKPVFGFVQSNSELFTPCPQTIWNHIQRSSRANPC
                     WSRISSVEHFHILVSCNIRRVFHTAVNYVSGPLYSYSHNYCMPICSPRLSSTLENNPCH
                     HTTDTAVNNGHGSGGAELTTSTVFSTRTATITACPSSVTNCPLRSKTTYVTTETLVVST
                     TVCPVADITGSSGAIITTQTASHPSATVAVVDNWSSMGGYDITTSTILSTRVITVTACP
                     SSVTNCPLRSKTTYASTETLVVATTVYPVPKVTNTKAKTPLPSVTRASEEGPSLTTSTI
                     LSTRIATVASCTGDDCRSSSSDSYVTTETLVVGTTVYTVYPEYVSVPTEGVDAMAAPTT
                     AATLLQTANSAGSSPKVVSSGSQPTSASETSTQGTGSSAGSSAESSEGSDAGSAADSSA
                     VSGAGSGAAADTTYTTTIIVESCSNDGTCTEYGSTITMAQTSNLAQPTVPPSPYSYTSY
                     LGSGLGWNHSTPVSSAHVWPQSSHQAGMSTAMVTSTRSASAVNALYTGSASAGSQWSML
                     QVVGMAVAILTAVLV"
     mRNA            join(9717..10043,10098..10450,10506..10829,10925..10973)
                     /locus_tag="CBS51388_002474"
                     /product="hypothetical protein"
     gene            9717..10973
                     /locus_tag="CBS51388_002474"
     CDS             join(9717..10043,10098..10450,10506..10829,10925..10973)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: fung_ggpps2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182:Polyprenyl synthetase (Score: 89.1; E-value:
                     4.2e-27)"
                     /gene_kind="biosynthetic"
                     /locus_tag="CBS51388_002474"
                     /product="hypothetical protein"
                     /protein_id="ncbi_CBS51388_002474-T1"
                     /sec_met_domain="fung_ggpps2 (E-value: 5.7e-115, bitscore:
                     377.7, seeds: 17, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MEPLQHHLPQTSLAFLALLAVPITALVWDRILNPLPTTKRAWLVG
                     KKQPSRITSLECPYSYIRQIYGKHHWAPFVDKLAPSLKLEDPPKYQLVLEIMDGIHLCL
                     ILVDDISDGSNFRKGHPAAHKIYGPSETANRAYYRVTQLLNRTVHEFPRLAPFLMQCLE
                     EILEGQDMSLVWRRDGLASFPVGPKERDAAYRQMASLKTGALFRLLGQLVLENKSMDAT
                     MTTVAWCSQLQNDCKNVYSTDYAKAKGALAEDLRNGELSFPIVVALDAPEGHLIARALE
                     YGSPHNIRNALRVIQREDVRSACLWDLKKSSASVQDWLEVWGRKEKMDVKSVKPILITD
                     CDKLCTEAQG"
     mRNA            join(11577..11750,11801..11955,12025..12330,12419..12797)
                     /locus_tag="CBS51388_002475"
                     /product="hypothetical protein"
     gene            11577..12797
                     /locus_tag="CBS51388_002475"
     CDS             join(11577..11750,11801..11955,12025..12330,12419..12797)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: fung_ggpps2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: fung_ggpps"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182:Polyprenyl synthetase (Score: 227.9; E-value:
                     2.3e-69)"
                     /gene_kind="biosynthetic"
                     /locus_tag="CBS51388_002475"
                     /product="hypothetical protein"
                     /protein_id="ncbi_CBS51388_002475-T1"
                     /sec_met_domain="fung_ggpps (E-value: 2.5e-140, bitscore:
                     461.1, seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="fung_ggpps2 (E-value: 2.6e-95, bitscore:
                     313.2, seeds: 17, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MLGFPMFSPETPDAWKMNTPYFPFVSSGVFSASIPSSPTNIEAAS
                     TSQSETSFLDKEKIVRGPLDYLLKSPGKDIRRKFIHAFNEWLRIPEEKLNIITEIVGLL
                     HTASLLIDDIQDNSKLRRGLPVAHSIFGIAQTINSANYAYFLAQERLRELNHPEAYEIY
                     TEELLRLHRGQGMDLYWRDSLTCPTEEDYIEMIANKTGGLFRLAIKLMHYVIELADLLG
                     VIFQIRDDYQNLQSGLYTKNKGFCEDLTEGKFSFLIIHSIHSNPNNHHLLNILRQRSED
                     DSVKKYAVEYIDSTGSFEYCRERLASLLEEADHMVKELESQVGHSKGIYEILSFLS"
     mRNA            13814..15397
                     /locus_tag="CBS51388_002476"
                     /product="hypothetical protein"
     gene            13814..15397
                     /locus_tag="CBS51388_002476"
     CDS             13814..15397
                     /codon_start=1
                     /locus_tag="CBS51388_002476"
                     /product="hypothetical protein"
                     /protein_id="ncbi_CBS51388_002476-T1"
                     /transl_table=1
                     /translation="MECGEEFIDPSLLCHSTLDGHDLDSRHFNLSNPQPYDLNLQQVPA
                     VLPNAQQRAVPSELFEDATTNNTTAPRGQLPRRRSRYLTRHSGTQAYSVMIPKASSFSP
                     MERWRNSPPEEEGCLIPDIIDALRDNPSQGVQTNLQNPGDDYSAFHGYRRAASITSGES
                     SASSRSTQKSGRSSSSAQNPLAVQGRHGNIRAGKTTRRKTKITSTTAQRRYCCTFCCDR
                     FKSKYDWARHEKSLHVTLEAWHCAPYGTTIMSSNEPSMTRCAFCGLTNPDSDHLEEHAA
                     TACEDESSSRRSFRRKDHLVQHLRLVHNVDSPPQLDSWRIGQSAITSRCGFCSQALMTW
                     KERVDHLAEHFRTGSTMAEWRGDHDFPPDFAALVANALPPYLIGSESQSMIPFSATNCD
                     VEDHLAQIYSRANWDAKDQKEASTITAPSAPSVALPLRALAPGVAPERLSSFTQVLTLH
                     LSRFAQEQMKKGVIPSDEMFQQESRRVLYDSDDSWNQTIADNPEWLATFKDLHFDKEKG
                     VHDSGENFAS"
     mRNA            16071..17207
                     /locus_tag="CBS51388_002477"
                     /product="hypothetical protein"
     gene            16071..17207
                     /locus_tag="CBS51388_002477"
     CDS             16071..17207
                     /codon_start=1
                     /locus_tag="CBS51388_002477"
                     /product="hypothetical protein"
                     /protein_id="ncbi_CBS51388_002477-T1"
                     /transl_table=1
                     /translation="MQKPIYKQFARCYSTSMPLQSHTTRPTIHVLGLGSIGTFTAHGLK
                     DIPNPPAVTLLLHRESLYQEYIRNNRQITLKPVTGDTMHHSDYNLEIYKQGAWHTPADS
                     PADHQIDNLVVTVKATQTVSALRALRSRLSRASTVLFLQNGCGMIDEVNEHLFPDPATR
                     PNYLAGVISHGVTLASPFNAIHTGASAISLGLVPRPHSQSSPNTRETGNQLQNRGGSEY
                     MLHNMPVSPRLSAKSYSFSDVFQIQLEKLAVNAFCNPACALHDSKNSILFEFPKLRRAI
                     LTEISSIVLRLPELRGVDGVEQRFAVDRLEETVNGILERTRETTCSMVVDLRNRRETEI
                     HFINGYWVRRGKEVGVSTAINEELMDKVLRRSAALRSE"
     mRNA            complement(join(17379..17984,18038..18185,18240..18490,
                     18532..18634,18912..18988,19053..19326,19385..19392))
                     /locus_tag="CBS51388_002478"
                     /product="hypothetical protein"
     gene            complement(17379..19392)
                     /locus_tag="CBS51388_002478"
     CDS             complement(join(17379..17984,18038..18185,18240..18490,
                     18532..18634,18912..18988,19053..19326,19385..19392))
                     /NRPS_PKS="Domain: NAD_binding_4 (136-364). E-value:
                     9.7e-15. Score: 46.0. Matches aSDomain:
                     nrpspksdomains_CBS51388_002478_NAD_binding_4.1"
                     /NRPS_PKS="type: other"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score: 91.7;
                     E-value: 9.6e-28)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="CBS51388_002478"
                     /product="hypothetical protein"
                     /protein_id="ncbi_CBS51388_002478-T1"
                     /sec_met_domain="NAD_binding_4 (E-value: 1e-13, bitscore:
                     46.0, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MTSAAEQYRTLVQTKGKVAPATLSNLFDQLPPLKPEQLLGSWNGG
                     FFDTGHSVGPTLQRIGWIGKDFNTLDDVDPVIVLREGRRASWGQWGHATVREMVFRGVL
                     STVMIYDDRPIFDHFRYNIENMSSSGHGQHVLLTGANGFVASHILSILLDAQRGYTVTA
                     TVRSQAKADEVVKAHPDWKGKIEFAIVSDFTSQKPFNTLFEENKIAFDYVIHTASPLKF
                     DIKDIQKEMIEPAVKGTTQILESAHQHGGSALKRFILLGSAVSVLDSFEDMSREGRPYT
                     EKSWNPVTAQQAIERNDTVLGYNVSKTQAERKAWEFMQANNPNFDLTVINPDIITGPMI
                     HPITGKGSINETNHFAIASFIDGTNSKVEDVRFPFYHFVDVRDVARSHVDALSNPAAGG
                     QRILLISGLITPQLVVNIIRKHFSELREKVPVGIPDRVLPEGVHPTGWDMRVSLDVLSK
                     GKGSQWQYIGLEESVKDAVQSMLQHNVLPV"
     aSDomain        complement(join(17754..17984,18038..18185,18240..18490,
                     18532..18585))
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CBS51388_002478_NAD_binding_4.1"
                     /evalue="9.70E-15"
                     /label="CBS51388_002478_NAD_binding_4.1"
                     /locus_tag="CBS51388_002478"
                     /score="46.0"
                     /tool="antismash"
                     /translation="LTGANGFVASHILSILLDAQRGYTVTATVRSQAKADEVVKAHPDW
                     KGKIEFAIVSDFTSQKPFNTLFEENKIAFDYVIHTASPLKFDIKDIQKEMIEPAVKGTT
                     QILESAHQHGGSALKRFILLGSAVSVLDSFEDMSREGRPYTEKSWNPVTAQQAIERNDT
                     VLGYNVSKTQAERKAWEFMQANNPNFDLTVINPDIITGPMIHPITGKGSINETNHFAIA
                     SFIDGTN"
     mRNA            complement(join(20325..21413,21467..21640))
                     /locus_tag="CBS51388_002479"
                     /product="hypothetical protein"
     gene            complement(20325..21640)
                     /locus_tag="CBS51388_002479"
     CDS             complement(join(20325..21413,21467..21640))
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1217:NADH:flavin oxidoreductase/NADH oxidase (Score:
                     324; E-value: 1.8e-98)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="CBS51388_002479"
                     /product="hypothetical protein"
                     /protein_id="ncbi_CBS51388_002479-T1"
                     /transl_table=1
                     /translation="MTQWPDITVKPAEGVSFYTPAQFPPAGTARNPQTSGRPIPNLFQP
                     LTIRGQTFQNRLGLAPMCQYSADDGHMTPWHIAHYGGIAQRGPGMMIIEATGVAPEGRI
                     TPGCVGLWKDSQIEPIRQVIEFAHSQGQKIGVQLGHAGRKASTLPPWLGGGVATNAVGG
                     WVDNVKAPSAISFSNDGITPKAMTREEIDQLKEAWVAATKRALAAGADFIEIHAAHGYL
                     LSSFLSPSSNQRTDEYGGSFENRIRLVLEIAQLSRETVGPHIPVFLRVSATDWVPTDEP
                     GWKGVDTVKLAGALAAQGMVDLIDISSGGIASGQKIKSGPAFQVPFAADVKKAVGDKLL
                     VAAVGMINNGNLAEQILTESNLDVILVGRAFQRDTGLAWHFAKDLDVEIAMAAQIRWGF
                     TSFRNASEYIQPNSMKASIFE"
ORIGIN
        1 tcaagcaggc cagtcaaggc ccaaggtagc caggacaggt cgcacggact caacagagcc
       61 atcgctgtcc atgaagacag ctccgataat agcttcaacg gcgctagcca tgactttgtc
      121 cgcgaccatt ccggcctggg ctggattgac aatgacaagt ttgtccaggc ccaggttacg
      181 tccagcctgg gcgatgtatg tgttgccggc cttcgttgag aggatactgt tcgtgaattc
      241 tgccataagg gatgagaatg tgattctggt taaatggaat aatatctacc tctgcccttt
      301 cgggcttcgt atccgtccaa cgccagaatc attctgagaa cggcatcccc aacgagagca
      361 agttgcttgt gaccatccgt gcgattgatc aatccgggca tgtgaacccc agcagcgact
      421 agtgcttcca tcgcacgatt cgggtcattg aagatgtacc cgataaggct ttgcagggtc
      481 tgggccctct ccgcaggagc aggaaatgaa ggcattgtgt cgtcgtagag ttgcttggtg
      541 tggttataac gagtatcaga gcggtcaaag cgagtatata agaaaagagg tctgtaggag
      601 agaacaggtt ggtaagggat tgggtgggga gggacaatca gatgcgagaa ggatggccct
      661 tttaacccct tccctggggt tggggagggg ttcatcatgt gatgttgctg catgtgctgc
      721 gccaactatc tagccttgca ttcgttggtc agcttgcctt gcgtatcctt gacccttcaa
      781 tactaacgga ttagctatca tccacaggat acagtacata cttctcttat ctttcggccg
      841 cttcacctgt caacataata gatctttatt tacattatga gagtactttc ggccggattt
      901 catgctcaaa atttgagact tattttgaac gctgttttaa gctggaaact gtaaccccgc
      961 aagttaagtg tctcagcctc gcgggtcacc ccatcgatcc cgcaaaggct gaattgaggt
     1021 tgcgagcagc acccccaccc gaatagtctg tcttggagct tggattctgg cccaatcaaa
     1081 ccctagacca acaacactgt gaacggctgt gcactaacta ttggcggcta gagccggtga
     1141 caatgaatta cgactgtggc tcccagattg catcagctag ggattcactt gttgaaaact
     1201 atagcgaaat ctcagctgtc ctttgatttt ggctcaacgg ttggaagtat ttggcagggt
     1261 tgaacttatt gctgttgctg ctatgtgaca aggaaagctc atctatattt atgggtatcg
     1321 caaggctttc tctacaccca tggtgttatc gcctactagg cagccttgct agtcctagca
     1381 cctaagggtc agtgcaccac aacacctgtg gcttttgggg acagagcatt gttgagtata
     1441 accccgcaat catacccttg cataaaaccc accaatagca taagctgcct tgatacagag
     1501 tatactgggc gcttctccga tggagccaca tcatgcgcca cgccggctcc tcctagttca
     1561 tctgctcagc cacttatgca gggctgcctg agtgactcat tgaggttgtc tcaagggtat
     1621 caaagtaaaa gctgagctcg gaggctttta gcagcagcga aggtaattac tgtgtattga
     1681 tatgaggtca gtgactttca tttaggcata gggacgccat aattgaagcg ataactagca
     1741 ggagtgagaa agaggagtat atggagaggg aactggtcac aagagttgag aaataactag
     1801 aataagagga cagtgatatg ctttttccta ataaccactg cgccgctacc cacccaaaac
     1861 atgtgcacac tgaccaacaa aatcaactag cgcagatacg gaaatgccag atacccatca
     1921 ccacccttct gacaaaggtt gaaacaatat gacagtagac cacacattaa gtagagggca
     1981 cgtagaaacc gcaacaccct cttaaagggc tcaattcaga tcctcataat ccaatcaaag
     2041 atggacaccc ccttgatcta ctccttgact gcatctttat ttgtggatag cgatgaagat
     2101 atgagcctac ggaaaagccc gcgttttggt ttcggagatt gctcgttgca ttggagtgtc
     2161 gaagcgtcgg aaaacgtact ctccgagtca ccctttggtt ggtttttcgc ctcatcttta
     2221 gcaagttcgt cgatgaatgt gggcatgtca cgcgtgccag aagggttcat gcgcatggtc
     2281 ggagctcgag atgtaggaga catggtgact ggataatgtg gtttggatga tgactctaag
     2341 atcaagttcc ccttcgtact agctggagaa tgagatcgta ggagatatgg aaggcgtcct
     2401 gttaaagcaa tgcaggacac aaagaacaat tgcacgagat aaagtagttt ttatattctg
     2461 aatgtggatg attcaatttc aagttcctct ttgtacgagg tggagagtga ggttgtagta
     2521 agagtctgag aagcttgtaa tgaagcaatg ctggatgaaa aggacagtta ccggagagga
     2581 agtggcctat atatactccg tatgtggctg atatactaaa gcgaggtata gaatgcttca
     2641 aggcaacaat attggccttc ctaaggcagt gacattcccg tagacaagca tgtgatgggg
     2701 tagacagcta aaatctcacg ggcttggcgt gaacacaagt gcccattttt ccgttctaga
     2761 atgccatgac gctgagggct gtggtgttca gcctcacgga aaaaaatatc ttagcaacat
     2821 cttgttcatg ccttcggcgc aggttttcag agaatgggaa gagcgggatt cagactttgc
     2881 cgtatatcga gagaggaccc ccatattata gctaagagct gttaaccata tcatatctag
     2941 gccctaacat ctgcgtacat ctcacataac gcagcatgaa tatctcgcat cgaagtctac
     3001 cccaaagttc tggagcttgg caagtggtct ggacacctgg gtatttgtga attgaatgac
     3061 gacatagaca ctttagccga cagactatat cctagacgtg agtcaggggg ctcattgtta
     3121 atttaatctt atgcgtgatg tagtctacta gtgcctaggc cacagccagt aagcgatatc
     3181 attggctata gctgaccgca ggcttcgaat gtcttcaaac cgccgacaac agtatacaac
     3241 aaccgcacat tgcaagtaag gtgtatttca cataatatat agattatgaa agtacttcta
     3301 ttcaatgcat taattgttta catttctaca tgaaaccata tttcagtatt cgaatcaaac
     3361 gacaagtaag gtcatgccta cgagacgcag gtaacaatgg gttagatgca ttgcgtcata
     3421 cctaagttgc ataaagtgaa aaagctgaaa caatcataac gtgactctca gagcagccgt
     3481 tcaacgccaa aatctatcct atgcatgatt tggcagccta agtggctgtg gaagaataat
     3541 gcacacagcg gctaatcagc atccaagatt tactaaaacg gctttagctc gcgctacctt
     3601 atctttccaa tcaacaacca ctcatcttgt ggcattttag acggcatggc caatgggaca
     3661 catcggattt cttctcatag tcacatggcc aacgacgtgg caactactta ccgtgactca
     3721 caacagacgt gtttgcctga ttgacgtgag taagctgctg ggagctagat tgaggtgtcc
     3781 aggggcattc cagactttgc ctgcatttgt tttcgaccgg acaatcggac ctcttctaac
     3841 tcagcactcc ctgtacgcag tgcaccgcca aattaatagc tctttcagag tcgaaagtaa
     3901 aaaaggggtt attgccatga ttcgcagcga aaaataaatc cagtctctcg gctactttga
     3961 ccttagttca tccgttctca ttgatcgaac aacatttttt tgcgtactat ttctggagaa
     4021 cggaacttac tctggtatat tcacccacca atagaaggga atacgacatg aacttggcat
     4081 tcgagcttag cactcggaga tatccgagct gttcggtgtt aaaggttccg gtggcgcaat
     4141 agttttaagt ctggaccggt ttcttggatg ctagtaaatg tccccgccaa tcagacccac
     4201 cgggtacctg atcccaatat ctaaaaggta aaaagtgccg atcagattcg tgagttcctt
     4261 gatggccatg cgctaatgtc gatttaatct ccgcgatacg agtggcaaag tggtgttatg
     4321 tggttgagat tttcaactag cgtggatcat aagtggggag gtactgactc gagatgtaga
     4381 gagggattgg gtctgctgtc tacgcagtct gctgaaggca tgttgactta tctctactta
     4441 ggacaattaa aaatgcatcg agcagcggat gtaatattat aagcggtaaa gtatgactag
     4501 tgtttctcta tggtataatg acaaccttct acatttccta taacgttacc cctgtatgcc
     4561 cacaacacga ccacaatttc cgttggacat ctggatggta gccgaagtgt catgaataga
     4621 cgccttggcg taaacagaag actgtgagca ggttgttgtg tggattagat agcagtatct
     4681 gatggaggaa gaaaccgcgt tgtagtagga catggcgcag gtggagctct ccatgcagct
     4741 gacacagcaa tcatatgcag aactggtgtc gccaacagtc aagctttcac cgggaacgtt
     4801 ggtgaaggcg atcaggtaca tgtattggcc cgcaaaagag ccaaattcag aggagagagg
     4861 gtcgccagca atattgctag acccgcacgc ctcgtagaag gtggtggtag ccacggcggc
     4921 cacggcgctg gtagtcgacg tcacggtggt tgtttcggca gccgcggatg tggtttcagt
     4981 gatggtggac gtggtactgt agctcagcgt ggttgagaca tcggaaggga ccacgactga
     5041 agtactggtg atagtgtttg tcacagtcac ggtggatgta ggagtgactg cggtagcagt
     5101 cgcgggagat tgggctactg tggagacggt tgtggtcttg acaataatct tctggtggca
     5161 ctcgacctct tgaggatatt gatagtcgtc cagccaggag gaacaatcgt cctgctcgat
     5221 caaggaccgc ttggcagcag tagctgtagg cagtgtttcc acaatgggag aaaaacctga
     5281 agagctggca attgtggacg tgctcgtgct cgtggtggag atggtgacag atacaatggc
     5341 agtgacagca gcaggagtga tagtcaccgt tgcagtgtca tactcagttg aggttgtcga
     5401 gaaagtatca gtgaccgtgt cagctgtgga aatggctgta gtcgtctcat agtcggtgat
     5461 ggtcacagtc gaggcgtcag gggtcacagt gacagtgtct tgtgtcgtcg aaaagacaac
     5521 aaccggtgtc gggtcatgga tggtgcgcgt gatggtagtg gtaggaacaa gtgccaatga
     5581 gtttgttccc agctgcgtgc ggcaggacat cgaaggcaca taggcctgac tgctggccac
     5641 aggcgagctg gccgcggggg tgatggctgc gacccgaccg agcagaaagc ccgcggcgac
     5701 aatgaagccc tggattgaca ttttcacagg ttggcaaaat atgaggtcaa tatgtatggc
     5761 aattactcaa aacactcggt aggttcggag tgtcctcgca ataagtactc cgtccctgaa
     5821 ttctggtggg attcggtgtc ggctattttc gccgtcgttg atagacccgc gatccagtgg
     5881 gcgtcaatag tccagctgaa tacgaaggct gagacaggaa ccagaaaata gctccgtcgc
     5941 gtgtgcattc cttctttgtc ttctctttgc cgaatctccg acagagagga aatccttgag
     6001 tgatctatat acagtgaccc gcctcttgca agagagnnnn nnnnnnnnnn nnnnnnnnnn
     6061 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     6121 nnnnnnnnnn nnnnnnttcg atacggttga gctgagtcga tcgctgtcag aatgggtcac
     6181 ctgctgatgc gaggatggat cctcgcctcg ttattgatgc aaaccagcat cgccatgaca
     6241 gtcgttgttg agccagcagc tgcgacttct accactactt cctctgctat cgcacatacg
     6301 catcatcact ggtcctatag ctcaaggtcc ttgcccagtc gcaggccatg cacacccagt
     6361 tattcgtcgt ctgttccttc ttcgaaggca gcaactccta ctccatcaat catcgtggta
     6421 ccctcgtcga gtgcagtccc ctcacccact acctcgcctg taagggaatc gccaactccc
     6481 agttcaagac cggtacccag tcgttcagca gctccccgcc cgcattggag ctatgtatcc
     6541 cggcctttac ctcagcgaag ccagtgttcg gcttcgtcca gagcaattcc gagctcttca
     6601 ctccctgtcc ccagactatc tggaatcaca tccagcgcag ttcccgcgct aacccctgtt
     6661 ggagccgcat ttcctcagtc gaacattttc acatcctcgt cagctgcaac attcgccgag
     6721 tcttccacac tgcagttaac tacgtcagcg gtcctctcta ctcgtacagc cacaattact
     6781 gcatgcccat ctgcagtccc agattgtcct ccacgctcga gaacaaccct tgtcaccaca
     6841 gtatgcccag ttaccgaggc tgctcgtgcg actcggacgg attctgcctc gccgacagca
     6901 accgacactg ctgtcaacaa tggtcatggc agcggtggcg cggagcttac aacttccacg
     6961 gttttcagca ctcgcactgc taccataact gcgtgtcctt cctcggtaac aaactgcccg
     7021 ctcaggtcga aaacgaccta tgtgaccacc gagaccttgg tagtctcaac cactgtttgc
     7081 cccgtagccg acatcactgg tagcagcggc gctataatca ctacccagac tgcatctcat
     7141 ccttcggcta ccgtggctgt cgttgacaac tggagcagca tgggtggata tgacattact
     7201 acttctacga tcttgagcac ccgtgtaatc actgttactg catgtccctc ttccgtgacc
     7261 aactgccccc tgagatcaaa gacgacttat gcaagcactg agacactggt tgtcgcgacg
     7321 actgtgtacc cagtcccgaa ggtcactaat accaaagcaa agactcctct tccatctgtc
     7381 acaagagcat cggaagaggg accatcactc accacctcca ccatcctgag cacccgcatt
     7441 gccacagttg ccagctgcac tggggatgac tgtcgcagtt catcgtctga ctcttatgtc
     7501 acgactgaga ccctcgttgt aggaacgacc gtttacacag tatatccaga atatgtatcc
     7561 gtcccaaccg aaggtgttga tgctatggct gctcctacga ccgctgccac gctcctccag
     7621 actgccaact cagcgggtag ctcccccaag gttgtttcat ctggatcgca gcccacatct
     7681 gcaagtgaga ctagcactca gggtacaggc tcaagtgcag gctcaagtgc ggagtcaagt
     7741 gaaggatcgg atgccggctc tgctgcagac tccagcgcag tgtccggtgc gggctcaggt
     7801 gcagccgcag acacaaccta caccaccacg attatcgtcg aatcatgctc caatgacgga
     7861 acctgcaccg agtatggcag taccatcaca atggcccaga cctccaatct tgctcagccc
     7921 actgtgcctc cctccccgta ttcgtacacc tcgtacttgg gctcaggatt gggttggaac
     7981 cacagtactc ctgtctcttc agcacatgtc tggccccaga gcagtcacca agctggcatg
     8041 agcacggcta tggttactag cacaagaagc gcaagtgccg ttaatgcatt gtacactggg
     8101 tctgcttctg caggttccca gtggtcgatg ctgcaggtgg tcggaatggc ggtagcaatt
     8161 ctgacggctg ttcttgtcta gttacgtgtg gggttatagt ataactttga atgttgtatg
     8221 tcgtctgatt acaatgtata ctattgtgct atgttcaatt gaaggtcctc caggcttatt
     8281 tgacttttgc ggtgggagca tggcctaatg ggtatggcca ttaattattc cctagtaaac
     8341 ttgagcccgc aagtattgat caacgggcag ccacatgggc caggacacaa ctactgtgat
     8401 catccttaat tttctttgca gataagactt tttatacgta catacaagca actaacaagc
     8461 ccaatatacc atatttgtgt ggattagtca gaatcaaagc aaaccagatc agcatagcca
     8521 gttgggttcc tcttaccaat gttgatcgga atggctgtgg cactatcccc atacaaactg
     8581 gtagcaagga tggagtgtcg gagtttcttg cccccggggc cgattgactc gatttagcaa
     8641 gccctcactg tgccaactct gtagtaccta atagcagcgc ctgtgttgca ccagaacggc
     8701 taagaaggtt atagtgggat actcataggg cccaacttat ctgttgtaga aaaatatcat
     8761 cttacatgcg gcaggtactc tcgtaatgct gtacattaaa gtaattgata ctgagcattc
     8821 cttgccatta ctataattta attaaaaggt ccttggatat gtgcgccgac ggattggaaa
     8881 tctggcgaca tactgctggc catgggtacg gacggctaac atgtttgctg caatttatga
     8941 tatggagttt gccagcgccg tatgacgaga cctgcatcga agcctcaatt ataggactat
     9001 cctgtcacct gcagtttgcc acaaaagtca atgagatttc actggcgcca atgtcaagcc
     9061 aggacattag tttggaatct gcggcatatt ctgcgtagtc cctcggaaaa tccatgtgtt
     9121 cgtaccagaa attccctgaa cactacatag ggagtgcaaa tattccacaa gacagatgcg
     9181 atgattcaac gatgatagta atggttcttt attcgattct tgatagcgaa ttggcttttt
     9241 gtggatttag attgcgcgtt catctaccca ttttcagatt gtagcgccaa atatatttac
     9301 ccaggtcagt aaatgcgtat gcagcattaa tagctatggg ccaaattgtt gggggcgcat
     9361 attaaggtgg ggcagtagtc aaaagttata tcttcactga ctgactcagg acatgtaatg
     9421 cagccgccaa agcgcagcaa ctttcatgat aagttgaagt gaccagccaa ttggacgcct
     9481 ttcgcatact taagcctgta cggagttgca gatttgtttg ttaaagcata tattatgcga
     9541 cgaagaattc cttgaattct tagcgagcta acagccaagg tacgctcgag agataacatc
     9601 attcatatat ctgccctgta cgtcctgcag ctattccggt tacaagatcc aggtcttcat
     9661 catctagtcg aatgacttat atggagcctt tctcatttct taacacggct atcatcatgg
     9721 agcccctcca gcatcatctt ccgcaaactt cgctggcttt tctcgcctta ctggccgtcc
     9781 cgataacggc gctggtatgg gatcgcatat tgaacccact tccgacaaca aagcgggctt
     9841 ggcttgttgg caagaagcaa ccatctcgga tcacttcact ggagtgcccc tacagctaca
     9901 tccgccaaat ctacggtaaa caccactggg ccccatttgt cgacaagctg gcgcccagcc
     9961 tcaagttgga ggacccgccg aagtaccagc tggtccttga gattatggac ggcatccatc
    10021 tctgtttaat actggttgat gatgtaagtg cagcacccca ctgaacatat ggagtagaga
    10081 gctaataacc ccataagatc tcggacggga gtaactttcg caagggacat cccgccgcgc
    10141 acaagatata cggcccttca gagactgcga accgtgccta ctatcgcgtg acacaacttt
    10201 taaaccggac cgtccacgaa tttcctcgtc ttgcgccctt tctgatgcag tgcctggagg
    10261 agatcctgga aggccaagat atgtcccttg tatggcgaag ggatggtctt gccagctttc
    10321 cagtgggtcc aaaggaacgg gatgcagcat atcggcaaat ggcgtcgctg aaaacgggcg
    10381 cattgtttcg tttgctcggt cagctggtac tagagaataa gtccatggat gctaccatga
    10441 ctacggtggc gtatgtgcaa agacatccga gcattgggga ttatggctga ttgacgtcta
    10501 cacaggtggt gctcacagct gcagaatgac tgcaagaacg tttattcgac cgattatgcg
    10561 aaagccaaag gtgcactggc agaagacctg cgcaacggcg agctttcctt ccccatagtg
    10621 gtggcattgg atgctcccga gggtcatctg atagcgcgcg ccttggaata cggctcaccc
    10681 cataatatcc gtaatgctct acgagtaatt caaagagaag atgtgcgtag cgcctgcttg
    10741 tgggatttga agaaatcaag tgcctccgta caggattggc tggaagtttg gggtcggaag
    10801 gaaaaaatgg atgtcaagag tgtgaagccg taagcgggaa tgtagatagg cgaatacttt
    10861 gcttagtgat ggaaactgtt gcaatactcc ttatttaaga gaatttaatc tctctatcct
    10921 ataggattct cattactgac tgcgataagc tttgcactga ggcacaggga taaggtctgt
    10981 acgacagtgt aagatggtac cgtataacta cgccgcatct tgcattagca gcgctttcac
    11041 gataggtatt ctgctatttt gccgataagc tggccacaat gaccattctc gagttataag
    11101 gagaattggc taggaagctg aacggagaaa ctttatcgag ccaatctcta tgactcgggc
    11161 gacctaagcg acctggtctt gtttgaaacc aacgcatagc atcccggatg tagaagagtc
    11221 tttggcaaac acaaggttaa cacgcggaca cggagcaact caccagtacc agtagcaagg
    11281 ctatttgatg aatgttctct gagattgctt gctgactaga cgtgcttcca agagcttgtc
    11341 gacgtcacta atttgctgat gacaagtgcc cagtaaagct acgccaagtg acagcaaaac
    11401 atgtagcaga agccaaaaca gttctataag gtgagactaa tagaaggcgt actcttatat
    11461 acctgagaga tatcaatgct tctccctcga aagcacacgt ttagttcctt cttagtagcc
    11521 ttcttttcca tcaacctcga tccgtacagt gctcttgacc tacaagagac gaaaaaatgc
    11581 tcggatttcc aatgttcagc ccagagacac ctgacgcctg gaagatgaat accccctact
    11641 ttccttttgt ttcctcgggt gtcttctctg catcgatacc atcatcaccc accaatatag
    11701 aagctgcgag tacttcacag tctgaaacaa gctttctgga caaggaaaag gtctgaagct
    11761 tcctgtccat ggtcagtctt cgtctgatgt gagataacag attgttcgag gaccacttga
    11821 ctaccttctt aaatcacctg ggaaggatat tcgtcgcaaa ttcatccacg cattcaacga
    11881 gtggctgcgc atcccagaag agaaattgaa tatcattaca gagattgttg gattgctcca
    11941 cacagcttcc ctactgtata ttccttttca tttcccacat gatcgaagtt cttaatgtct
    12001 cggaaactag ctgatctttt gaagaatcga tgacattcag gacaattcca aacttcgacg
    12061 cggcctccca gtggcccaca gcatcttcgg cattgcccag accatcaact ctgctaatta
    12121 tgcgtacttt ttggcgcagg agcggctccg cgaactgaat catcccgaag cgtacgaaat
    12181 atacaccgaa gaactgctcc gtctgcaccg cggtcaaggt atggacttgt actggcggga
    12241 ttctctgacc tgtcccacag aggaggacta tatcgagatg atcgcaaata agacgggtgg
    12301 ccttttccga ctggctatca agcttatgca gttggaaact gaaacaaaaa ggcaagtgtt
    12361 acatatctgt cacaatactg taaagctcct tgtcacacag cagactgact ctatgcagct
    12421 atgtcatcga gctagcagat ttgttggggg tgatctttca gattcgagat gattaccaaa
    12481 atttgcagag cggactatac acgaagaaca agggattctg tgaggatttg acggagggca
    12541 aattttcctt cctgatcatc cacagtatcc acagtaaccc gaataatcat catctgctga
    12601 atatattgcg gcaacggagc gaagacgatt cggtgaagaa gtatgctgtg gagtatatcg
    12661 actcgacagg gagtttcgaa tattgtcggg aacggctcgc ttccttgttg gaagaggcgg
    12721 atcatatggt caaagagcta gagagtcagg ttggacattc gaaggggatc tacgaaatat
    12781 tgagcttttt gtcgtaattg ctagatgtgg ggggcctgtg cttcattgct aggtatcttg
    12841 ctgaaacaaa tagtgttgtt gtcttgtcgt cacttgcgtc tagaaatgaa gtgcgtttga
    12901 tactcacatt ttttgtttca aaaaatcaga gatattatac ggatagatat tacagtcttt
    12961 cagtatgaac aagatatcat aaactggcat ggtgagattt caaagcccgt tgaacttcac
    13021 ccacccgtga cttgtgaccg tctttcggtt acactggctt acatgtatta gctcacagta
    13081 tggggtcaga ggtgcaggag gaaatggaat gttgggcgac aaggagaagc tgaatactac
    13141 acatgcattt caagtttgat gggctgtgct tatcattatt gtcccaaggc tggttggctc
    13201 ccaggagaat ttagccgaca gatgcacgct gagtctgtct gcaggtgccg cgttgatacc
    13261 cagtctgctt ggtcttcagc gagaacaaca atgtcaatgg gtcttatgga gtgtattgaa
    13321 gctccaatat ttgattcgta aggcattcat tcatgtatca tcacatgtcg atgaggaatc
    13381 aatcacggtt caatggccag gatacattgc cgccgctact gtctactagg acaatgtaga
    13441 ggacaattcc cccttaattc aatagatggt gtattttgaa tcgatttgcg gagtgctacc
    13501 caatctctgt cacgtcggca gtgaccattc aaggctcaaa ttgtagccac agggcctcaa
    13561 ccatgaactg gatagtttca tcgggatttg ctgagaggcc gaccgccacc ctgttggcct
    13621 gaggcagaat agattacata atgtctcaag caccggcacc caactcaaaa taggatgaag
    13681 aggaatgaag ttactcttgc ttcctttcca tgatgtctat tgggtaggag aatgcgataa
    13741 tggttagccc gcagaccctt attatccgaa actctgaaga gaaactttgc ttagaatagc
    13801 tgcagctgcc agcatggaat gtggcgaaga gttcatcgat ccatctctgc tgtgccactc
    13861 gacgctcgac gggcatgatt tggactccag gcattttaat ctttccaatc cgcagcctta
    13921 tgatctgaat ctccagcaag taccagcggt cctgcccaac gcccagcaac gggctgtgcc
    13981 aagcgagcta tttgaggatg cgaccaccaa caacactact gccccgcggg gccaacttcc
    14041 acggcgtaga agtcggtact taacgaggca ttcggggaca caagcatact ctgtgatgat
    14101 accaaaagca agcagcttca gtcctatgga gcgctggcgg aattcgcccc ctgaggaaga
    14161 aggttgccta atccccgata tcatcgatgc tctcagagac aacccaagcc aaggggtcca
    14221 aaccaacttg caaaaccccg gcgacgacta cagtgcgttc catgggtatc ggagagctgc
    14281 ttcaattact agcggggagt ctagtgcatc ctcgcgaagc acccagaaat ccgggcgttc
    14341 aagctcatcg gcccagaatc cattggcggt acaggggcgt cacggcaaca tcagggcggg
    14401 caagactacg agacgaaaga cgaagattac ttcgaccact gctcagcgtc gatactgctg
    14461 cacattctgc tgcgaccggt tcaaaagcaa gtatgactgg gcacgacatg agaaatcgct
    14521 ccacgtcacc ttggaagcat ggcactgcgc gccttatggc actaccatta tgtcctctaa
    14581 tgaaccttct atgactagat gtgccttctg tgggcttact aaccccgact ccgaccatct
    14641 ggaggaacac gccgccacag cttgcgagga cgagtccagc agtcgacgtt ccttccgccg
    14701 taaagatcac ttagtgcagc atctacggct cgtacacaat gtcgactccc cgccacaact
    14761 cgacagttgg aggatcggac agtccgccat cacctcgcgg tgcggcttct gcagtcaagc
    14821 gctgatgacc tggaaagagc gtgtggacca tctagccgaa cactttcgga caggctcgac
    14881 aatggcagag tggcgcggcg accatgactt cccgcctgat ttcgccgccc tagtagccaa
    14941 tgcattgccc ccttacctca tcggctcaga atctcagagc atgattccat tttcagcgac
    15001 aaattgcgat gtggaagatc atttggcgca gatttactcc cgagctaatt gggacgcgaa
    15061 agaccagaaa gaggccagca ctattacagc cccttcggct ccaagtgtag ccttgccctt
    15121 gcgggctctt gcaccgggtg ttgcccccga gcggctcagc tcgttcaccc aagtgctaac
    15181 gctgcatctc agccggtttg cacaggaaca gatgaaaaag ggcgtgattc cgagtgacga
    15241 gatgttccag caggaatcca gacgagtact gtatgactca gatgattcat ggaaccagac
    15301 gattgcagat aatccggagt ggctggctac ttttaaggat ctgcatttcg ataaagagaa
    15361 gggtgttcat gattctggcg aaaactttgc ctcatgaacc gaatgaatac aacgtgtact
    15421 tagggtccca tgtctccctt tctttccttc actctcgggt gatgtactta tacccccagc
    15481 gtagtatacc ctgagcagtc tgtgcttcct aatctcaggg ctgctgatgc tgctgccaac
    15541 cggagatgca acagccgatc tgtatctccg ggagcgatcg tcactgtggt caaaatatgg
    15601 gatgtaggta ccggatgagc gggttagaga gcgtttcggc tatcctttga acgaagagat
    15661 ggacctatgg tgagatagta tggcgctatg agagttggtg agaccggaaa tttgtgtaag
    15721 ccgaaggatt gtcttcagga tgtctcgaat gtgtggtgaa ggggagagcc aaaggctagc
    15781 ggggacacgt tcggcgggtt tgggggtggg agcgttggaa caaaatcgtg taaactgtaa
    15841 actttgctgg ttagccatgt tctcatacat tgtatgtaaa gtaatcattc aatgttcgga
    15901 taatagctag gtgtgggtgt gatgaaggtg aggattagac tggaaaagct ggaagaaact
    15961 tcatcttgcc acagggcgta gggcgtaagg cgtacatgaa gcgacacttc gataaaaccg
    16021 atgattctca atcacagcaa ggtgttcaac acagacagag ctcgataaca atgcaaaaac
    16081 caatatacaa acagtttgca cggtgctact ctacaagcat gccactgcaa tcccatacca
    16141 ctcgtccgac gatccacgtc ctcggtctcg gcagcattgg cacattcacg gctcacggcc
    16201 taaaagacat cccgaaccct ccagctgtca ccttactcct ccatcgagaa tcactctacc
    16261 aagaatacat acggaataat cgccagataa ctctaaaacc agtgaccggt gacacgatgc
    16321 accacagcga ctacaacctc gagatctaca aacaaggcgc ctggcatacc ccggccgact
    16381 ctccagcaga ccaccagatc gacaatctag ttgtaacagt taaagcaacg caaacggtat
    16441 ctgccctccg tgccctcaga tcccgactct ctcgagcctc gactgttctc ttcctacaaa
    16501 atggatgtgg tatgatcgac gaggtcaacg aacacctgtt cccagacccc gcaaccagac
    16561 caaactacct tgccggagtc atttcgcacg gagtaacgct tgcgtctccc tttaatgcga
    16621 tacacactgg cgcatccgca atatctttgg gattggttcc tcgcccgcat tcacagtcct
    16681 ccccaaacac ccgagagacc ggtaaccagc tacaaaacag aggcggatcc gaatacatgc
    16741 tgcacaacat gccagtctcc cccagactat ccgccaaatc gtattctttt tcggatgtgt
    16801 tccagatcca gctggaaaag ttagctgtga acgcattttg taacccagcc tgtgcgctcc
    16861 acgactcgaa gaacagcatt cttttcgaat ttcccaaact acgtcgggcg atcctcacag
    16921 agatatcaag tattgtgctg cgcttgccag agttaagagg tgtggatgga gtagagcaac
    16981 gatttgcggt tgacaggcta gaagaaacgg tgaatggtat cttggagcgg acgagagaga
    17041 ccacttgctc gatggttgtt gatttgcgga ataggcgtga gacggagatt cacttcatca
    17101 atgggtactg ggttcgacga gggaaggagg ttggtgtgtc tactgcaatt aatgaggagt
    17161 tgatggataa ggtgttgagg aggagtgctg ctttgcgctc tgagtaactt gggagccatg
    17221 tttttcggat gctcagatgt gaatacacac caatgatggc tgaaatgtgg atataagaag
    17281 cccgtgtagg ggattttgag tccaatgtgt ctactgagaa gtctacaatt cactaatgtc
    17341 tctgtcaaat tgacatgtaa gtacaaaatt gcgttacatt atacaggcaa cacgttgtgc
    17401 tgaagcatag actgcactgc atccttcaca ctctcctcca agccaatata ctgccactga
    17461 ctgccctttc ccttggagag cacgtctaag ctaactcgca tatcccaccc ggtaggatgc
    17521 accccctcag gcagtaccct atccggtata ccgaccggaa ccttttcgcg tagttctgaa
    17581 aaatgctttc ggatgatatt gactactagc tgcggtgtaa taagccccga gatcagcagg
    17641 atacgctgcc ctccggcagc gggattagaa agtgcatcca catggctcct tgccacgtcg
    17701 cgcacgtcga caaagtgata gaatggaaac cgtacgtcct caaccttgga attagtcccg
    17761 tcgatgaagc tcgcaatggc aaaatgatta gtttcattga tcgacccctt cccggtgatt
    17821 ggatggatca tgggtccagt gataatatcg ggattaataa ctgtgaggtc aaagttggga
    17881 ttatttgcct gcataaattc ccaggctttg cgctcggctt gggtcttaga aacgttatag
    17941 cccagcactg tgtcattacg ctcgattgcc tgttgcgcag ttacctagac ttccattagc
    18001 gtgtgtcttg ccggtttcag gttcttgaac gacgaactgg attccaactt ttctcggtgt
    18061 atgggcgtcc ttctcgactc atgtcttcga aggaatccag gactgagacc gcgctgccta
    18121 aaaggatgaa gcgtttgagc gcgcttccac cgtgttggtg agcgctttcc agaatttgag
    18181 tcgtgctgga ggtgtatttt agtggttata acacggttgc gaagacacta ttggcttacc
    18241 ccttgacagc cggttcaatc atttctttct ggatatcctt aatgtcaaac ttcaatgggg
    18301 atgccgtatg aatgacataa tcgaaggcaa ttttgttctc ttcgaacaag gtgttaaacg
    18361 gtttttggga ggtgaaatcc gacacgatcg caaattcaat cttccctttc caatcagggt
    18421 gagccttaac cacttcgtcc gcttttgctt gagatcgcac tgtcgcggtc accgtgtagc
    18481 cacgctgagc ctgtcagatc ctgcacgtct cgttagagag tagtcaccta catccagcaa
    18541 gatagagagg atatgcgatg cgacaaaacc gtttgccccg gttaaaagaa catgctggcc
    18601 gtgtcctgac gatgacatgt tctcaatgtt gtaactatag atggtcgtgt caaaaggcct
    18661 ctgggcctgt caatcaagaa atcctcttgg agactgcaaa gtccgattta atttcttgag
    18721 agccgatgtc acgccactta aaggttacga gatactccat gtaagaggta cgtgtacgca
    18781 aacgtcatat ctgaacggga tctgaacctt aacctcgatt tataatctat cgcgtcaagt
    18841 aaaagtaaaa gtcccctccc tcaacagcct ttccctccat cacccccgcc accaagttgt
    18901 catccacata ccggaaatgg tcaaaaattg gtctgtcgtc atagatcatt acagttgaca
    18961 gcacaccccg aaacaccatt tcccggacct aatacgcaac attagctgaa tttggacttc
    19021 catgcgatga caggcataat gtccttgcat accgttgcgt gcccccactg cccccagcta
    19081 gctctccttc cttcgcgaag gacaataacg gggtcgacat catccaaggt gttaaagtcc
    19141 ttgccgatcc agccgatgcg ttgaagcgtt ggaccaacag agtgtcccgt gtcgaaaaac
    19201 ccgccgttcc agctgcccaa gagttgttcg ggctttagag gaggcagttg gtcaaagaga
    19261 ttgctgagcg ttgcgggagc aaccttcccc ttggtttgca cgagagtgcg gtattgctct
    19321 gccgcacttg atggtagctg agtcaatatt ttgtctccct cttgttcggc tgagtgttcc
    19381 ttacgatgtc atttttccaa gtgtgatgtc ttagtggatg gtgtgacagt gtgcagtttc
    19441 gacgccgata cactctactc gtttcagcgc attagcaaga tatttatatt cacgtctaga
    19501 cacgaaggct gcaattatta atggtagagc aaaatatacg ggaattggat gaacaaagtt
    19561 ggtgtcgaat agtaattacg aactagtctc gctgcagaag cttcttgatc tcatgtcatt
    19621 cattcatctt gcatgggact gttttcagag tcagccttcg acccacggac agcccgccca
    19681 ttttccgcag aactgcgccc tacggtggat cgctccacat ctcgggatct tcggagagtt
    19741 ctgggctttg ctcatcggag gctttttgaa tgttactccg tactacgatt actggatgat
    19801 cgtgaggttt ctctattgct tacttactaa ttgatgtttc atacagcaac ggccctggaa
    19861 gtgtgccttg tcgaagagaa ctggcttcat gatgttgccg ccttgccacc gtcctgatcg
    19921 catgtaaacg tgtgatgatg gcaaatccgg tgcagcaaca gtggaaacca atgttgatta
    19981 tcaggataca tggtttttgg gacatgtctc tgtgactact ctaaggatta gccatgacat
    20041 atgatcggtt ttggtctgtt tagtgacgct ttgacagcaa cttatgcatg ttgaagcgca
    20101 gtactttatt attttataca tgtgatacta ctggtagctt cattccaggt aactgcagcc
    20161 tggagtgtaa acgagcataa tcttgatcct gtcatttgat gctagcaatc ctgtaaaccg
    20221 agttgaagcc agtatatgta aaagtgctaa tatgtatcga ggaaaatgaa ggcctcttgt
    20281 ctatagtcta tcaatttatc cgaaaatata acgatcgcaa ctgtctattc aaaaatggaa
    20341 gccttcatcg agttaggctg gatgtactcc gaagcatttc ggaaactggt gaacccccaa
    20401 cggatctgcg ccgccatagc aatctcaaca tccagatcct tcgcaaagtg ccacgcaagt
    20461 cctgtatccc gctggaaagc acgcccaacc aatataacat ccaagttgct ttctgtcagg
    20521 atctgctcgg ccaggttgcc attgttgatc atgcccacag cagcgacgag caacttgtcg
    20581 cccacagcct tcttcacatc agctgcaaat ggaacctgga acgcaggacc cgatttgatc
    20641 ttttgcccag aggcgatgcc accactgctg atgtcgatca aatccaccat gccttgtgca
    20701 gcgagtgctc ccgccaattt cactgtgtcc acgcccttcc agcctggctc gtcggtggga
    20761 acccagtcgg tagcggaaac acggaggaac acagggatgt gggggcccac tgtctcgcgg
    20821 ctaagttgag cgatttcgag cactaatcga atgcggttct caaagctccc gccgtactca
    20881 tcagtacgtt ggttcgaaga cgggctcaag aaggaagaaa gaagataacc gtgggcagcg
    20941 tggatctcga taaaatcagc accagcagcc aaggcgcgct ttgttgcggc cacccacgcc
    21001 tccttcagct ggtcgatctc ctccctcgtc atagccttcg gcgtaatgcc atcgttggaa
    21061 aaggagatgg cgctgggagc cttgacattg tccacccagc cgcccactgc gttggtcgcg
    21121 acaccaccac ccaaccaagg aggaagagtc gaagccttgc gtccagcatg gcccagctga
    21181 actccgatct tctgtccttg actgtgggcg aactcgatga cttgtctgat gggttcaatt
    21241 tgggagtcct tccagagacc aacgcagcca ggagtgatgc gcccctcagg cgcaacgcca
    21301 gtggcttcaa tgatcatcat gccggggccg cgctgggcga taccaccata gtgggcgata
    21361 tgccatgggg tcatatgtcc atcatcggca ctatattggc acattggggc cagctgtcgg
    21421 agctgttagt atcaaggatt acacttggat ggctgaaagt actcacgccc aggcgattct
    21481 ggaaagtctg gcccctgatc gtcaaaggct ggaagaggtt agggataggc cgtccgctcg
    21541 tttgagggtt gcgtgctgtg ccggccggag ggaattgcgc tggggtgtag aaggacactc
    21601 cttcggcagg cttgacagtg atatcgggcc actgagtcat
//
