LOCUS       An09                   18086 bp    DNA     linear   PLN 01-NOV-2020
DEFINITION  Aspergillus niger strain CBS513.88.
ACCESSION   An09
VERSION     An09
KEYWORDS    .
SOURCE      Aspergillus niger
  ORGANISM  Aspergillus niger
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Eurotiomycetes; Eurotiomycetidae; Eurotiales; Aspergillaceae;
            Aspergillus; Aspergillus subgen. Circumdati.
COMMENT     'Annotated using 1.7.4'.
            ##antiSMASH-Data-START##
            Version      :: 5.0.0
            Run date     :: 2020-11-03 02:41:14
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 1377829
            Orig. end    :: 1395915
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..18086
                     /aStool="rule-based-clusters"
                     /contig_edge="False"
                     /core_location="join{[1386751:1386910](+),
                     [1386955:1386971](+), [1387033:1387199](+),
                     [1387246:1387336](+), [1387380:1387414](+),
                     [1387474:1387692](+), [1387738:1387814](+)}"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      join(8923..9081,9127..9142,9205..9370,9418..9507,
                     9552..9585,9646..9863,9910..9985)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     cand_cluster    1..18086
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..18086
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="8"
                     /rules="(Terpene_synth or Terpene_synth_C or phytoene_synt
                     or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps
                     or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /tool="antismash"
     mRNA            complement(join(1..544,616..1106))
                     /locus_tag="CBS51388_006342"
                     /product="hypothetical protein"
     gene            complement(1..1106)
                     /locus_tag="CBS51388_006342"
     CDS             complement(join(1..544,616..1106))
                     /codon_start=1
                     /locus_tag="CBS51388_006342"
                     /product="hypothetical protein"
                     /protein_id="ncbi_CBS51388_006342-T1"
                     /transl_table=1
                     /translation="MSSPPPPSSNPLKRPSISSASSQPLGSHPKRPRMHPLRQTSFPNT
                     IDADTRTYSDAGSVTGSFTGSLGGTSADGVFLTKGKKRGRKSKAEKEREREEGSLRAGM
                     DRLGSVDVDGASVRGGASGGAGGGGGGEDADEDEDFDDEGELLGREEGTTDTEAEKKNM
                     ALLVDAFNPIQSERYDLFKRAKLRKETLRRIVNHALSQSVPASVVTTINGFTKVFAGEI
                     IEKARTVQAEWAIAHDQAALAAIEAEQATTTTTTTTTPGGIKQEPMERGPMSTPMGKKD
                     VKLPPNPHRGQLLPSHLREALRRYKRDGEGGGVGFSGLSMGNLGVRGSVTWSAGSVXGR
                     RIFR"
     mRNA            complement(join(1736..3114,3171..3291))
                     /locus_tag="CBS51388_006343"
                     /product="hypothetical protein"
     gene            complement(1736..3291)
                     /locus_tag="CBS51388_006343"
     CDS             complement(join(1736..3114,3171..3291))
                     /codon_start=1
                     /locus_tag="CBS51388_006343"
                     /product="hypothetical protein"
                     /protein_id="ncbi_CBS51388_006343-T1"
                     /transl_table=1
                     /translation="MVYIGIPQHYTTSPSSFMGTPSLTINLEATQDLDSTNAFEGPEKL
                     LEVWFAPSAQELGSAGPAGLKAVPEEIWKDMLDLVNCQVLSIVSSEDVDAYLLSESSMF
                     VWPHKLILKTCGTTTLLSGLPRILEVAALFGGFPRATAPASRGISVAAAPYRVFYSRKN
                     FLFPDRQRGPHRSWRDEVRTMDKLFLNGSAYMIGKMNGEHWYLYLTEPNTLLTPPTSPR
                     VESEDPVTETKVLQVPAAGAYQTREDQDETLEVLMTDLDEENAKQFYLDHATAVAEKRY
                     CNFEADNDDHVDVFSNNSDMDDVSSNGSRVLPPELTTEGHALGTVVSESCGLSDVYPKS
                     KFPESRIDAYLFTPCGFSANGVIPTPDQNTGTHYFTVHVTPEPHCSYASFETNVPHSQN
                     GQTTQEIIQQVVNIFKPGRFTVTLFEAKPETTTADGELDHIKEVKYIERQAARRTKMEN
                     VAGYRRVDRIVHDLDGYDLVFRYYERLDWKGGAPRLGEERV"
     assembly_gap    4133..4232
                     /estimated_length=unknown
                     /gap_type="within scaffold"
                     /linkage_evidence="paired-ends"
     mRNA            complement(join(4728..5282,5339..5757,5825..6194))
                     /locus_tag="CBS51388_006344"
                     /product="hypothetical protein"
     gene            complement(4728..6194)
                     /locus_tag="CBS51388_006344"
     CDS             complement(join(4728..5282,5339..5757,5825..6194))
                     /codon_start=1
                     /locus_tag="CBS51388_006344"
                     /product="hypothetical protein"
                     /protein_id="ncbi_CBS51388_006344-T1"
                     /transl_table=1
                     /translation="MSVWNPDNIRDVAESVGVVNLSNDVTENLARDVEYRIAQVLEEAL
                     KFMRHSRRTLLTTQDVAQALRVLDVEPLYGYESTRPLRFGEASLGPGQPLFYVEDEEVD
                     FEKLINAPLPRVPREISFTAHWLAVEGVQPSIPQNPTAADSRNMELMSKGPNASSTLAA
                     MSGGGNVSVKPLVKHVLSKELQLYFEKVCNAFLDESSEEYRTSGYASLREDPGLHQLVP
                     YFVQFISEKVTHGLKDVFVLTQVMHMAEALVQNKSLYVDPYIASLVPPILTCLIGRQLG
                     GSAELTEQFALRDLAASLLGLIAKKYSNSSHTLKPRLARSCLKTFLDPSKPFGAHYGAV
                     IGLHAVGGAEAVRVLIMPNLPTYGNLLKDGMAEESPRRPEAERVLSVLLGVLNTLREGR
                     MALANGHGGMVTDGLRDRLSQKVGEFLAAKISDAGEVDLAHAIVESSS"
     mRNA            join(8923..9081,9127..9142,9205..9370,9418..9507,
                     9552..9585,9646..9863,9910..9985)
                     /locus_tag="CBS51388_006345"
                     /product="hypothetical protein"
     gene            8923..9985
                     /locus_tag="CBS51388_006345"
     CDS             join(8923..9081,9127..9142,9205..9370,9418..9507,
                     9552..9585,9646..9863,9910..9985)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: Terpene_synth_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052:Terpene synthase/cyclase metal-binding domain
                     protein (Score: 142.4; E-value: 3.6e-43)"
                     /gene_kind="biosynthetic"
                     /locus_tag="CBS51388_006345"
                     /product="hypothetical protein"
                     /protein_id="ncbi_CBS51388_006345-T1"
                     /sec_met_domain="Terpene_synth_C (E-value: 8.9e-11,
                     bitscore: 36.7, seeds: 87, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MSTAFDNGELKVDLDGVKRMMDELLAVMTNEGVFRPRAPIVIAFK
                     SIWDRLSESNCSAGTRRRFANSMRDYSEACIQQVIMQSKFQGSETLSVEEFIVMRRGSI
                     ATTPLYALFEYANGLNIPDEVFESSSIKKLERVSTEVTVIQNDIVSYRKEQILDESSNL
                     IKIYLRQGFSVQAAFDEAGKLLAACYRDWYLTLADLPSWGEDVDAQVQTYIDGLQNTVL
                     ADIHWSFRAERYWKSNAEIQKDRTIEVRVK"
     mRNA            join(10549..10840,10888..10954,11013..11121,11177..11263,
                     11451..11522,11574..12053)
                     /locus_tag="CBS51388_006346"
                     /product="hypothetical protein"
     gene            10549..12053
                     /locus_tag="CBS51388_006346"
     CDS             join(10549..10840,10888..10954,11013..11121,11177..11263,
                     11451..11522,11574..12053)
                     /codon_start=1
                     /locus_tag="CBS51388_006346"
                     /product="hypothetical protein"
                     /protein_id="ncbi_CBS51388_006346-T1"
                     /transl_table=1
                     /translation="MEASHLDGMEAEAFERLTIIATIPQTPVQSYIQETLAAILDEVSF
                     REGHLSITLKQRGKKFASLFINPRTLALETSEIQTYTTYRWPGGDMNEALKFTAALRVL
                     AAIAEAVQAGLVVSKRDIYYSDPICFGSQKTVDTLVDDLAHTMGVDRAALYVGAAAKGL
                     VVGYYQMTTTSAGVVDARLSNQAVYRRLASSNYHIRSAAGKGVLVTGKGYPDLSTRAFV
                     RKLFDHSHQLTKKPQFYALVDGDPDGMAIMATYKYGSVAFAHENRNLNVPGLHWLGLRL
                     AEVVAGADPLGDGTLLHLTKRDRKKAIDMLSKNPVWEADGPEPEWRVELQRMLMLNVKA
                     EMEILYDMEGGLTGWLDRKLVHLIQNSK"
     mRNA            complement(join(12382..12635,12752..12998))
                     /locus_tag="CBS51388_006347"
                     /product="hypothetical protein"
     gene            complement(12382..12998)
                     /locus_tag="CBS51388_006347"
     CDS             complement(join(12382..12635,12752..12998))
                     /codon_start=1
                     /locus_tag="CBS51388_006347"
                     /product="hypothetical protein"
                     /protein_id="ncbi_CBS51388_006347-T1"
                     /transl_table=1
                     /translation="MSSVAQKRLFHEYKNLSTNPPEGITAGPVTEDDMFHWEALIQGPE
                     GTPFEGGVFAAELKFPKDYPLSPPTMKFVGGGVWHPNVYPNGTVCISILHPPGDDPNHY
                     EHASERWSPIQSVEKILISVMSMLAEPNDESPANVEAAKMWRERRGEYERKVRDEVRKG
                     LGL"
     mRNA            complement(join(13823..14914,14962..15486))
                     /locus_tag="CBS51388_006348"
                     /product="hypothetical protein"
     gene            complement(13823..15486)
                     /locus_tag="CBS51388_006348"
     CDS             complement(join(13823..14914,14962..15486))
                     /codon_start=1
                     /locus_tag="CBS51388_006348"
                     /product="hypothetical protein"
                     /protein_id="ncbi_CBS51388_006348-T1"
                     /transl_table=1
                     /translation="MWSALRTPPAQCLRAPGRALASSLRGRPNPRGPRNSIRRPEPIRR
                     DVPASRAPEPSNTETSPENPTPQYDPSQNTLLAPVHIPEDPHGVIKETHPATGILANSG
                     LVVQRQLELMNVMIGFEQANKYVIMDANGNHIGYMAEQEKGMVNMMARQSFRTHRSFVT
                     HVFDKHENEVLRFHRPFSWINSRIRVYDPLDLAKGAYSSSTALQATSAGSLVQPTGDSN
                     ARVSSLGLDEIRVIGEAQQQWAPLRRKYNLFTYHHSPNPATEMKTEKLPLNQMDLSNKQ
                     QMQLVQSSQSGQETGEYHQFAYVDEPFLSWDFGLRSADKQLIGSVNRNFAGFAREIFTD
                     TGVYALRMDSASPSEEFLDKNRAATGMTFDQRAVMLATAVSIDFDYFSRHSNSGGFGFM
                     PLWIPGFGGEAAAGGAAGGAAAGEAGAVGEAAAGTLGRAGAAGGMADGAAAGAAGAGAM
                     AGYEAMSRGMGGSQPAPDQQAAPVDQQPPTPGQTGPYGDVWGEESENPWGKEPENTWGQ
                     EEDPWADEADEGEGGDDFDWF"
     mRNA            complement(join(16554..16747,16800..16983))
                     /locus_tag="CBS51388_006349"
                     /product="hypothetical protein"
     gene            complement(16554..16983)
                     /locus_tag="CBS51388_006349"
     CDS             complement(join(16554..16747,16800..16983))
                     /codon_start=1
                     /locus_tag="CBS51388_006349"
                     /product="hypothetical protein"
                     /protein_id="ncbi_CBS51388_006349-T1"
                     /transl_table=1
                     /translation="MFSWIRLLGALLLLASVAHAQFQFFEHMFGGGGGGGGHQGRQQAA
                     QNVPSDSSRYQSQWDSAHCDKYLCPGTLACVHFPHHCPCPHPDVEEKVELGEGSAVCVS
                     KGGYKEGEAARKIELARKGLL"
     mRNA            17235..18086
                     /locus_tag="CBS51388_006350"
                     /product="hypothetical protein"
     gene            17235..18086
                     /locus_tag="CBS51388_006350"
     CDS             17235..18086
                     /codon_start=1
                     /locus_tag="CBS51388_006350"
                     /product="hypothetical protein"
                     /protein_id="ncbi_CBS51388_006350-T1"
                     /transl_table=1
                     /translation="MFQPRLLAPLRALERGLTRTPTAATTSIRNTSSLLRNTSSILSAT
                     SITQTKLTPLASPTLHQFLQVRHASHASQGTANRHSRDPAGKRLGAKRTAGEYVVPGCI
                     IFRQRGTKWFPGENCAMGRDHTIYAAEAGYVRYYLDPERHPDRKYIGVVFEKEGKLPTP
                     KNAPTRRKLNRVAVRFEPEEELAAKQGDLVAKIGEEGTQVGSATKVEAAQAAVQLRPGY
                     MYREANWSIGRAAEKAGITAKPYNRKNRWLAWRKRTAKAERMAQMKSLKNKKKGAKKKG
                     GK"
ORIGIN
        1 ttaccggaag atgcgccgtc cgncaacact acccgccgac caagtcaccg accctcgcac
       61 ccccagattg cccatactca gacccgagaa ccctacgcct ccaccctctc catcccgctt
      121 ataccgccgc agcgcttctc ttagatgcga gggcagcaac tggccccgat ggggattcgg
      181 aggcagctta acatccttct tccccatagg cgtagacatg ggcccccttt ccatgggctc
      241 ctgcttaata cccccaggtg ttgtggttgt cgttgttgtt gtcgtcgcct gttcagcttc
      301 aattgcagcc aaagccgcct gatcatgagc gatagcccac tccgcctgca cggtacgagc
      361 cttctcaata atctcacccg caaacacctt cgtaaagcca ttaatcgttg taaccacact
      421 agccggcaca gactgcgaca gcgcatgatt gacaatacgt cgtagcgtct cctttcgtaa
      481 tttggctcgt ttgaacaggt catatcgctc cgactggatg ggattgaatg catccaccaa
      541 caacctacac cagaaccagt tagcaacttc gcccacaagc cagatataga gtcgtccaaa
      601 aggagggatg catacgccat attcttcttc tccgcctccg tatccgtcgt cccctcttcc
      661 ctccccaaca actccccctc atcatcaaaa tcctcatcct catctgcatc ttctcctccc
      721 cctcctcctc cggcaccgcc agaagcacca cccctcactg acgcgccatc cacatccacc
      781 gaccccagtc gatccattcc cgcccgcaaa ctcccttctt ccctctcgcg ctccttctcc
      841 gctttactct tcctgccgcg cttctttccc ttcgttagga acaccccatc tgcgctggtc
      901 ccgcccagac tgcctgtaaa gctgcccgtc acgctgccgg catcgctgta ggtgcgcgtg
      961 tctgcgtcga tggtgttcgg gaaggaggtc tggcggaggg ggtgcatgcg cggtcgcttg
     1021 ggatggctgc cgagtggttg agaggaggcc gaggagatgg aggggcgttt gagggggttt
     1081 gaggacggtg gtggtggtga ggacatgatg tgtttgtgtt aagaaatggt gtgatgggtg
     1141 atgttgatgt tgatgttgct ttgtcgagag ccgacaaggc ttgctcgcag cgcggatgaa
     1201 aagtcgtgtc tcgatctgtc tgcgaaatct cggtaaggcg cgaataaaga ctcagctgtt
     1261 caagttattc aggatagaaa gtgtacacgt gatggactgg gttatggaga ctgctggggg
     1321 ggaagatgat gcgacggagt gtggatgaaa gaaccaaagg aaggcggctt atcggtgtta
     1381 cggcgcccca tccggcaagt ctgccgagtg gtcgactttc cgccggcgcg ctcctgcacc
     1441 cgcccgctgc ttatttctac ttcactcgtt cgtcgctcaa ctactcgggt tttctacgat
     1501 caatgcacct gaccagtccg taggacggat aatatttgtt cgaaataacc acaatgccac
     1561 aaatccgtaa gcgaaggtgg atactaacat tgctcaaaaa ggaacaaagc tcaatcgctc
     1621 gatgatagga aagtaacagc tgacaaaacc cgaaattgga aacagtcaag aaacgatatc
     1681 attctcccac ttccttctca cctctcatgc atggacagac accgtgttcg ctctctcaaa
     1741 cgcgctcttc tccgagccga ggggcccccc ctttccagtc aagacgttcg tagtagcgga
     1801 acacgaggtc atatccgtcc aagtcatgca cgatccgatc cacccgacga tatcctgcca
     1861 cgttttccat cttggtgcga cgagctgcct gccgctcaat gtacttgacc tccttgatgt
     1921 ggtccaactc gccgtcggcg gtagtagtct ccggcttagc ctcgaacaag gtcaccgtga
     1981 agcgtccagg cttgaagatg ttcaccacct gctgaataat ctcctgcgta gtctggccgt
     2041 tctgcgagtg cggcacgttg gtctcaaacg acgcatacga gcagtgaggc tccggagtca
     2101 catgcaccgt gaagtagtgt gttccggtgt tctggtcagg cgtggggatg acgccattgg
     2161 cggagaatcc gcacggggta aacaggtagg cgtcgatccg agactcgggg aacttggact
     2221 tcggatagac gtccgaaaga ccacacgact ccgacacgac cgttcccaaa gcatgaccct
     2281 cggtagtcag ctcagggggc aagacgcggc tgccgttgga cgacacatca tccatgtcgg
     2341 agttgttgct gaaaacatca acgtggtcgt cattgtcggc ctcgaagttg cagtaacgct
     2401 tctcggcaac agcagtagcg tggtcgaggt agaactgctt ggcgttctcc tcatccaggt
     2461 cggtcatcaa cacctccaga gtctcgtcct ggtcttcgcg agtctggtag gcaccagctg
     2521 cgggcacttg aagcaccttg gtctcggtca ccggatcctc cgactcgacg cgagggctgg
     2581 tcgggggagt gagcaaggtg ttgggctcag tcaggtagag gtaccagtgc tcgccgttca
     2641 tcttgccaat catgtaggcg ctgccgttga ggaagagctt gtccatggtg cgaacctcgt
     2701 ctctccagct gcggtgggga ccgcgctgac ggtcggggaa gaggaagttc ttgcggctgt
     2761 agaacacacg gtacggggcc gcagcgacgg agatgccgcg ggaagcaggt gcggtagcgc
     2821 gagggaagcc accaaacaaa gcggcaactt cgagaatgcg cggaagtccc gacagcaggg
     2881 tcgtcgtacc acaggtcttc aggatcagct tgtgcggcca gacgaacatg ctggactcgg
     2941 acaagagata ggcgtcgaca tcctcggacg agacgatgga gagcacttgg cagttgacga
     3001 ggtcaagcat gtccttccag atctcttcag gcacagcctt caagccggca ggaccggcag
     3061 aacccagttc ctgagcggac ggggcaaacc aaacctccag aagcttctcg gggccttcat
     3121 tcacgtcagt atagttccaa catagagcca ttagtatcac agccacatac cttcgaaggc
     3181 gttggtggaa tcaagatcct gggttgcctc aaggttgatc gtcaaggacg gggtccccat
     3241 gaaagaggac ggcgacgtcg tgtagtgctg ggggatccca atgtagacca tcttgaccga
     3301 ttgataatgc agcaaattaa tcggtaaagc ggacggagca gcgatatagc aggtgcgcgc
     3361 gactggatgt gtggaccgta gacaaagagc ctaggaagca ctatctgctg cccagacgaa
     3421 caggggggct atgtccgtct gagagagtag gcccttaatc tgtttttctg gtaattggca
     3481 ctcagccaaa gaggggtagt ttcggtagaa gcctgaaggg ctgctaggga gggcggaaag
     3541 agagggaaag gaggaaaaag cctctggaaa agggaatggt gactatctgg tcgtgaccct
     3601 cgtgctggaa gataccgata ccggcgaaag tatcgggtct agcagacgag agtatctgct
     3661 tttgaaatgt gggagagaaa aaagtgaggt ttgcgcgact ggagaaaaaa ggtggggttc
     3721 aagcgtgtta tcggggccta ctcgcgatct gttagccatg acagaaactt ttgacccacc
     3781 ggagacgaag tgaagagact aaggaaagaa gacaaacggc aacaaacata cttggcaggc
     3841 ttagacaggt accgtagtag atccttcggg ttcatggaag gcaggacaga agacgagctt
     3901 aaaacagcac gatgtcgtga gaagccacag cactgaacat ctgcgaggcg actttcgacg
     3961 gcaacgataa cgggtagggc aagtgtgcag cggaatgcag caaagcgatt tggctctttg
     4021 atcactcaat gactcaaaga caaccaaagc gatagaacct ccaccggatg agtgaggagg
     4081 aaggagaggg aaataaataa gatttcaaaa aaggcacgcg gacgtggggg ggnnnnnnnn
     4141 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4201 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nngatgagat gctcctttcg aatggccgga
     4261 aaagaaggcc aggaataagg aatgagccga tcggattttc cctgccaaac ggaaaaagcc
     4321 cgacatttcg tgcccaacca ggcaggcggt agtacaaggg tcgacttctt ctcaaaaggg
     4381 agggtgacgt cgtgtctccc tcccatcggg aaatcggtct cacaacttcc accactacta
     4441 aattccctcc cagcacaatg agcaggttga agtcaacaaa gcatcaagat attatgcaga
     4501 ggtacaattc gctagctagc attcaagaat agtcctgatt ccctccttct aaaacaccct
     4561 ttgccccaaa cgccgaattc tgtccatgcc cagcaacaaa cactcaaact aagaaaaatg
     4621 aaagaaagca cgcatggctc ttcacccgct gcccctaaag atgtacatcc aaagtagata
     4681 cagaatgaga tgctacttca agttgtagag agagaaatgc agcagaatca ggaggacgac
     4741 tccacaatgg catgagcgag gtcaacttcc cccgcgtcac taatcttcgc ggccaggaac
     4801 tcacccactt tctgactcag ccgatctcga agaccatccg tcaccatccc gccatgaccg
     4861 ttggccagtg ccatccggcc ctcccgtagc gtgttcagca cccccagcag cacgctaagc
     4921 acccgctctg cctccggccg gcgtggactc tcctccgcca tgccatcctt gagcaggttg
     4981 ccgtacgtcg gcagattagg catgatcagc acccgcaccg cctctgcacc gccaaccgca
     5041 tgtagtccga tcaccgcgcc atagtgcgcc ccaaagggtt tggacgggtc caggaacgtc
     5101 ttcaggcacg accgggccag tcgtggcttg agggtgtgcg acgaattgga atatttcttg
     5161 gcgatgaggc ccagaagcga tgcggcaagg tcgcgcaggg caaattgctc cgtcagttca
     5221 gcactgcccc cgagttgtcg accgatcagg cacgtcagaa taggtggaac aagtgaggcg
     5281 atctatcagg agtcagtgga atgtaatctg cgttgttcat gtgacaatca tgactcacat
     5341 atgggtccac gtagagagac ttgttctgta ccagagcctc ggccatgtgc atcacctgcg
     5401 tcaggacaaa gacgtccttc agcccatgcg tcaccttctc cgaaatgaat tgcacgaaat
     5461 atggcaccag ctggtgtagt ccggggtctt ctcggagact ggcataaccc gacgtcctgt
     5521 attcctcact ggactcgtcc aggaaggcgt tgcagacctt ctcgaagtat agctggagct
     5581 ccttggaaag cacatgcttc accagaggct tgacggagac atttcctcct ccactcatgg
     5641 ccgccaatgt agagcttgcg ttgggtccct tggacatcag ttccatgttt ctcgagtcgg
     5701 ccgccgtggg attctgaggg atggacggtt gtacaccttc aaccgccaac caatgggctt
     5761 aatggagtca gcatgccaac acttcattgt aaatatttcc atagagcagc agggccaagt
     5821 ttacctgtga aagagatctc gcgaggaacc ctgggcaacg gcgcatttat caacttctca
     5881 aagtccactt cttcatcctc cacgtagaac aacggctgac cagggcccag tgacgcctct
     5941 ccgaaccgca aaggccttgt agactcgtat ccgtacagtg gctccacatc cagcacgcgc
     6001 agcgcctgcg cgacatcttg tgtcgtgagt agcgtgcgtc gactgtggcg catgaatttg
     6061 agggcctctt ccaggacctg cgcgatgcgg tactcgacgt cgcgggcaag gttctcagtg
     6121 acatcattgc tgaggttcac gacaccgacc gactcggcaa catcgcgaat attatcgggg
     6181 ttccaaacgg acatggtggg cgtgagtgtt gaggtggagg taaaagaacg gaggtaggag
     6241 gtatcgggtg ggcgggaggg tgtaacgtcg tcggttcgtc aacgagtggg ccaggtattt
     6301 cctgcaattt gaggcgagta gatgaccatc aaatttatta tccgggaagg ccgaaaatca
     6361 ttctgggagg cccagaggtg caatgtcgaa atgaacgata gcagataaat gcgacgcggg
     6421 aacggagaga gcttcggagg cagaaggcgg agaaaacctg ccgctgggca tccacacgtg
     6481 catcttcaac tatctccgtg taggaatcgc aaacttgaat caggatatag tgtttacaaa
     6541 catatcaaat atcatacgag gtgaaagcaa ttataccata tttgtagtac caagtttttt
     6601 agtttgttga atgaagcata agatagagaa cagctaaaaa gaagcgttca tacgtctaat
     6661 ttgctaggtc taaaatgccc tatcctacca caagaggatg cagttgaccc cttcaccaat
     6721 acatggatat ttttcgcatt tcttgccaat ccatgatcac ttcactccat tgccctctcg
     6781 cccatgtggc ataggtcgat ctggcacttg ttgaaaacat ttttcaagcc aaatatacaa
     6841 ctcaaagtaa gcaaggctta agatacggct gtcagttact atatcccatg ggtaacacag
     6901 tcataatgca caaccaccgt ttaagattgc tatggaagat cgcattgccc ccacattcct
     6961 atgtacgccc tcaagaatga ttatgttgag cgtggtgcac gataattagg gtcgcacaac
     7021 agttctcctt tgtccgatgg aattatccag atgcctgaga aagacgaacc tacaaagtca
     7081 caaatttaag ggctatagtg tgggtaactt tcaatatcaa cctgtaggat ttcatctgca
     7141 agtttctaag ttcagaagct cttacaaaat accaactacc aggaatatgt gcaagaaaca
     7201 aggagcataa ttcaatccgt gctcggcagc actgagattt cattacatca ctacgtataa
     7261 ttcgggctcc tatcaaggat tacactgcat tgacagaaat catgactcct gtaacataca
     7321 aagaagtccc agatataagc cacaatacac tacccgcaac cttatccagt cgtgccacat
     7381 cgtgcctgga agcacaatag gcagaaatgg taggcaccgt ctttagaatc ccgctggagg
     7441 agacattgat aagggaagct ccgtgacctt gcttgaccat ttgtccactt aaggaagtga
     7501 gcgatgctgg acaggttggt atcaatcact tgaccacatt cagtctcgtc caacccaaat
     7561 attggcatgc aatctccact cacgcctgcg ttggccgaag tcctcgattg tttcctcaac
     7621 aaactgcgca cctggtacta ttggagctcg agacatttgt cttgacgaag catgctttat
     7681 taatcttggt tgacaatatt ctttttcgtt tgcctactag tggcttcgtc catgtcggta
     7741 atagcgaggt tcattccgga catcgaggtc tggcagaatt taggtttgta ttctggaacg
     7801 gacagcgatg cggttacact agctcaagtc ggtcaactgg ggctactttg aaatggttcg
     7861 taagggtcgg cgttagtgtc atcagtgaac tatgccagcc cactcatata ggaagatgtt
     7921 ttcatttgtc tttccagttg ctgaataacc tcacatcatt gctctaaaag gaagcggtag
     7981 tgccagtgac atgtttgcca cgagtggacc agtggaccaa tagatgccac taacgatctt
     8041 ctcgcactcg accagagtac gtttcatcat aactcaaacg cattgggaag gagtatggct
     8101 tgccttatgt ggggtaactg tgatgcatat tcaattgcga tagggcagag atacagcatt
     8161 cctgttcgaa tcagcaaagg tggtaatgcc ctgcagatcc ttgcatagag tcccgagcaa
     8221 gcttcgattg atcttgatga gctgctgttg accacagagg gaggaaatga gggggaatga
     8281 ttcagttaga cggtgacatc actcttatga aggcagtccg aaggggatat cactgtagct
     8341 gtcgagaaat gcatccattc atatttagta ttgtgaaacg tcataggagc catcgacgag
     8401 ttggcttata agtattcagc cgacacccta cttgtccatc ttatccagca taaactgata
     8461 tacccattta cgagccagga agatgggttg ggacgctgac actatcgtcg aggtgaaatt
     8521 gcctccgtta tttgtaagct tcgttgcgag aaaggctcca gtgaatcggc attatgaagc
     8581 tatcagggag gagtcggagc agtggctgat caagtataag tgaccctttc ttcactctag
     8641 taccttcatc taaaactttg aagggcctgc aaatttgatg aaaatatggc acgatctatt
     8701 cacaagactg actttgggta cttcttggcc attatggccc ctaatgcaga gcgagatcag
     8761 ttgcgaacga tgtgtgattg gggaaactgg gtacgtccgc gttgatctcc ctgtgttgat
     8821 tctctttagg tgtactgtgt atactaatct gaatcaaggt ttttcctttt gatgatggta
     8881 gtgttttcct gttcaatcgc acttccctgt tctcacgatg cgatgtcaac agctttcgac
     8941 aatggagagt tgaaagtaga tctggatggt gtgaaaagaa tgatggacga gcttttggcc
     9001 gtcatgacaa acgaaggagt ctttagaccg agagctccta ttgttattgc gttcaagtcc
     9061 atctgggata gactatccga ggtgagtatt atgtcgatga gactgtgatc ctcgctaata
     9121 tttcagtcga actgctctgc cggtaatcac attgtcagcc tcaattgatc tgaatatgaa
     9181 gttgatggga tcaacgacac acaggaaccc gtcgtcggtt tgctaattca atgcgagact
     9241 attccgaagc gtgtattcag caggtcatca tgcaatccaa attccaaggc agtgaaacac
     9301 tgtcagtcga agaatttatc gtaatgagac gtggaagtat tgcgacgacg cctctatatg
     9361 cgctatttga gtaggccttt tccctccctg gaaggatcaa acgtgctgac gatccagata
     9421 tgccaatgga ttgaacattc cagatgaagt gtttgagagt tcatccatca aaaagctgga
     9481 aagagtcagc actgaagtga cggtcatgta agaaccttgt ccgttgtaga agccggctac
     9541 tgactccaca gccaaaatga catcgtttcc tatcggaagg agcaagtatg tgcatattta
     9601 tggtccgcca gctataggta cagaatgact aaccttccct tccagatcct cgatgaaagc
     9661 agcaacttga tcaaaatata tctccggcaa ggcttctcag ttcaagctgc tttcgacgaa
     9721 gctggaaagc tactggctgc atgctatcgt gattggtatt tgacactagc tgatttaccc
     9781 agctggggcg aagatgtcga tgcacaggtt cagacgtata ttgatggcct ccaaaatact
     9841 gttctggctg atatccactg gaggtaagag ctaatctcaa cttcgctacg atgtctgatg
     9901 gcgatgtagt ttccgagcgg aacgttattg gaaatcaaat gcggaaatac agaaggatag
     9961 aacgattgag gtgcgagtga aatgaggatg tcttgactgt gcttggaatg tattaggttg
    10021 tctgattcag actgaagggg gcatgactta agtcttatgg cacttggcag tgaaacatgt
    10081 tagtagtgct ctttatgagc attcgcattg ctgatgcttg tttaaacatg aatcagtata
    10141 attagcttac ttgaataata actctggtcg cagcctagtc atcttccacc cccggctccc
    10201 taagcaggat gtacttcatt tcttgtatga agatatgagc gatattccag gaaaccggtt
    10261 tagctaactc tgtgcatgtg actacgtgcc accggcttgc tatactttga acactggcca
    10321 gtcaagatca ttatgtagtg atttttgttg gttccggcca tttacttgcc attttatatt
    10381 gtacaagaag aactcatctc actagttgta acgtgattag gtacaatata tgttgggtcg
    10441 catactcgca acccctcttg gactatttcc acctttcgcc tccggaccat cgccgtccca
    10501 cccctacagg tcatcctctc ctaacccatc ttgttgatcc tagaaacaat ggaagcatca
    10561 catttagatg gcatggaagc cgaggcgttc gaacgactaa caatcatcgc tacaattccc
    10621 caaacaccag tccaaagcta cattcaggaa acgctagcag caatcctgga tgaagtatcc
    10681 ttccgtgaag gccacctctc tattaccctc aaacagagag gtaaaaagtt tgcctcacta
    10741 ttcattaacc cacgtacatt ggccctggag acgtcggaga tacagacata caccacctac
    10801 agatggcccg gcggcgatat gaacgaagca ttgaaattca gtacgatatg ttgtcaccat
    10861 tcagatactc tgctaatgaa gacacagctg ccgctcttcg agtcctcgcg gccatcgcag
    10921 aggcagttca ggcggggttg gtggtctcta agaggtaaac aacacggacc accagtgtac
    10981 tctaacactt tcgaacacta aatttcacat agagacatat actacagtga tcctatctgc
    11041 ttcggctccc agaaaaccgt cgatacactc gttgatgacc tggcacacac aatgggggtg
    11101 gatcgtgctg cattatatgt ggttcgtggg cctcaacagt acctacttcc agactgctaa
    11161 gtatcctgca acacaggggg cagcagcaaa aggacttgtc gtgggatact atcagatgac
    11221 caccacaagc gcgggagtag tggacgcgcg gttatcaaac caggtccgtt gcagtcatca
    11281 ctactgcaca cagcatggac tgatgttcgc aggatactct agtacctaga atgcaagaca
    11341 tccacaaagt cgaccttaaa gatgttgcct gggtactggt tctagagaag gaggtccctg
    11401 ctgccatcaa aaactttata tatcaagctg gagtgaactg acaccctcag gccgtatacc
    11461 gtcgactcgc aagcagcaac taccacatca gatctgcagc aggcaagggc gtcctcgtca
    11521 ctgtaagtgc tgatacccct attacattct aagagacata ccaaccattc cagggaaaag
    11581 gatatcctga tctcagtact cgggcattcg tccgtaaact cttcgaccac agccaccaac
    11641 tcaccaagaa accgcaattc tacgccttag tggacggtga ccccgacggc atggccatta
    11701 tggccacata caagtatggc tctgtggctt ttgcccacga aaaccggaac ttgaatgtgc
    11761 ccggtctcca ctggctaggt ttgagactag cggaggtggt tgcaggagct gatccactag
    11821 gcgatggcac gctactccat cttacgaagc gggataggaa gaaggccatc gatatgctgt
    11881 ctaaaaatcc tgtctgggag gctgatggac cggagccgga atggcgggtc gagctgcagc
    11941 gaatgctcat gctgaatgtc aaggcagaga tggagatcct gtatgacatg gagggtggct
    12001 tgacaggatg gctagatagg aagctggtcc atctcataca aaacagtaag taggtaggac
    12061 gtattcatga cttcgtacca ttatcacaac aaaagataat gatatatact gaacaaagca
    12121 tctatgcatt cctgaccatg catctacccc agtagtgggc gtcaaataga atatatataa
    12181 agatgaaaga aagagagaga aagaacgaac gcaccacaac gccaacccaa gcaaccaatg
    12241 catccatcca agctatgcca caatttcctc cacgacacag agtatagaca gacagtgagc
    12301 aaccagccca gcaaccggtt acttatatac ggccaaaccc ctcccattca ccattcaact
    12361 catattaaag aagagagggt ttcacagccc caatcccttc ctaacctcat ccctcacctt
    12421 ccgctcatac tcccccctcc gctccctcca catcttcgca gcctccacat tcgccggaga
    12481 ctcatcattc ggctccgcca acatactcat aacggagata agaatcttct ccacgctctg
    12541 gatcggcgac caccgctccg aagcatgttc gtaatggttg gggtcgtcac cgggggggtg
    12601 gaggatggaa atacacacgg ttccgttggg gtatactata cgtatgtcca aaacacgtta
    12661 gcataagctc aaccaagcat caccagaaaa aaaactagaa gacaagaaag atccagatag
    12721 agaaagaaag ggaaaagaag gagttattta ccattaggat gccaaacccc accacccaca
    12781 aacttcattg taggcggact aagcggataa tctttaggga acttcaactc ggccgcgaac
    12841 acgccgccct cgaagggcgt accttcaggc ccctggatta gtgcttccca gtggaacatg
    12901 tcatcttcgg tgacggggcc ggcggtgatg ccctcggggg ggttggtgga gaggtttttg
    12961 tattcgtgga agaggcgttt ctgggcgacg gaggacattt tgattgatca ctgccttcct
    13021 ttctctttga gagaagtatt gattttaatt attggcttaa taatttctcc ggcgtcgtgg
    13081 gagggaagca ggtagtgggt ttttggtgct ggtggtggtg gcggtctggc tgtctatctg
    13141 gcgattagat aaagagggga gaggagagtg cggagatcgg accggagagg gtgaggacac
    13201 cgggggtact taataggggt ggtggttatg tacctggggt ggcgttgagg agataggact
    13261 aagaaaaact ttttagaggt cggtttactg gggaaggtga gtgggttgga attgaattgg
    13321 aggagaaatc aaggtttgcc actctgaaag ccaatgaatg attgagtgat tgaggttcca
    13381 ttcatcgatg gttgagccgg tgggatgtgt tgggtgcctg aggctgcaat gatgcttatc
    13441 gccgctttca tcagtatgga aggagaatga tcttgagttt atttctggct agcattgttt
    13501 catttttcgc gtgatattat acagttattt ggagattttt ttgtcgttat ggtacatcgg
    13561 gctaatcatc gtcagtcagc tgcataaacc gctttgcact tcaagcaggg ccgagtatga
    13621 atgacatcga tgtctactcg gtcagatcat gtcgagtatg ccgcaggcca tgtcattgaa
    13681 gccgttacgg tgattctcag tgcccccgat tacatgagct ctgtcgtcgt tatccctgca
    13741 tgaatggggg gatagtatat gtctgaccgt ctcacaatgt caaccatcct gatcttactg
    13801 cctgtttgta gttatcagcc gcttaaaacc aatcgaaatc atcgcctccc tcgccctcgt
    13861 cggcttcatc tgcccacgga tcctcttcct ggccccatgt gttctcaggc tcctttcccc
    13921 atgggttctc ggactcttcc ccccagacat ctccatacgg acccgtttga cctggcgtcg
    13981 gtggctgttg gtctacaggt gccgcttgct gatcgggagc aggctggctg cctcccatcc
    14041 cacgggacat ggcttcgtag ccagccattg cgcccgcacc tgctgcacct gctgcagcgc
    14101 catcagccat tccaccggct gccccagccc gaccaagagt tcccgcggcc gcttccccca
    14161 cggcacctgc ttcaccggct gctgcgcccc cggcagcacc cccagcagct gcctcaccac
    14221 caaatccagg gatccagaga ggcatgaaac caaatccacc cgagttgcta tggcgactaa
    14281 agtagtcaaa gtcaatgctc acagcggttg ccagcatcac ggcacgctgg tcgaatgtca
    14341 tcccagtagc cgcacggttc ttgtcgagga actcttcgct gggagaagca gagtccattc
    14401 gcagagcata gacacccgta tccgtgaaga tttcccgggc aaacccggca aagttgcgat
    14461 tcacagagcc gatcagctgt ttgtcagccg agcgtagacc aaaatcccac gacaagaaag
    14521 gctcgtccac gtaggcgaat tggtgatatt cgcccgtttc ttggccactc tgagatgatt
    14581 ggaccagctg catttgctgc ttattagaca aatccatctg gttaagcggt agcttctctg
    14641 ttttcatctc tgtcgctgga tttggcgagt ggtgatacgt gaagaggttg tatttccgcc
    14701 gtagtggagc ccattgttgc tgagcctctc cgataacccg tatttcatcc aagcccaagg
    14761 atgaaacccg agcattcgag tcccctgtag gctggaccag agatccggct gaggttgcct
    14821 gtagtgcagt ggacgaggaa taggcaccct ttgccaggtc gagaggatca tatacgcgga
    14881 tacgggagtt gatccacgag aacggacggt ggaactacgc agtcagcatc atccacaagt
    14941 aactggcaga tcgataccta cccgaagcac ttcattctca tgcttgtcaa acacatgcgt
    15001 cacgaagctt cgatgcgttc ggaacgattg tcgcgccatc atgttcacca tgcctttctc
    15061 ctgctccgcc atatagccaa tatggttgcc gttggcatcc ataatgacgt atttgttggc
    15121 ttgttcgaat ccaatcatca cattcatgag ctccaactgc cgctgcacca ccagacctga
    15181 gttggcgagg atacccgtcg ccgggtgcgt ctcttttatc acgccatgag ggtcttcggg
    15241 gatgtgaact ggggcgagta gggtgttctg ggaggggtca tattgaggcg tgggattttc
    15301 gggagatgtc tctgtattgc tgggttcagg cgctcgcgac gctgggacgt ctcttctgat
    15361 gggctctggc ctgcgtatgg aatttcgggg gcctcggggg ttgggtcggc cgcgaagtga
    15421 gctggcgaga gctcgaccgg gagctcgaag gcactgcgcc ggtggtgttc ggagcgcact
    15481 ccacattcca gtgttggggg ccagtcggta aaaatgtatg atgcgaaatt agacaaaggt
    15541 atgtaaggtg actgtagcac cgagaagtag agttgaataa gctgaagatg gaagagaaag
    15601 atggaagatt cccgcgatga cgaagttgcg ggagcgggcg gagttaacgg cgataagacg
    15661 ctgatcatcc atccgctgcc ctctttgcct tcatccaccc cgcaaactga ttgcgagata
    15721 actcagggta tttattttac agtactttct catctgtgtt gggaatacct acaaacaagt
    15781 gtataagaag ctctaactcc agtgtatagg aacaatctcc aaccggctca gttttaatac
    15841 tggatatctg gactcgattg atactaaata tatttattta acacgttctg cccttgaagt
    15901 gatctgctcc aactgatcac acaatgattc aagtactact tatgaccata agtcatgata
    15961 atccacacgg aacagcagtt tcagtagtat cgagggacac ccttatttag acagatgatt
    16021 gtagtcaatt gaagaattga cctctcccat gtcgttccag attgtctttt ccagctctgc
    16081 ctacgtggac taacctactc cacagctgtg ctgatagtct gcctaagact gattgcgata
    16141 caaccgctta caacacacag tgctgataag attgacattg gaatgcatat tataattttt
    16201 aaaatgacgc cgtaaagtaa gcgcagacgc ctaaaatgta cgtattaggt gcggattggt
    16261 ctctctgatc aacaacccga gcgcaaggcg atatcccgga tttcaagttg ctgactgctc
    16321 caatcaagag agcagctgcc tatgtaataa tccaagagcc cttcgacagt aacatagcga
    16381 taatgctgca agagtcactc agccaggacg cagatcaacg cgcaggcctc agaagtgaca
    16441 tcctgaacag tagaatccat aagacatatt cagaaccaat acgcacaaac accaacacca
    16501 ataaccccca attcagctga aaagcgacat gtaaccactt tcagacattt caatcacaaa
    16561 agacccttgc gcgccagctc aatcttccgc gccgcctcac cctccttgta tcctcccttt
    16621 gacacacaaa cggcacttcc ttctccaagc tcaaccttct cttcgacatc gggatgcgga
    16681 cacgggcaat gatgcgggaa atggacgcat gcgagcgtgc cagggcagag gtatttatcg
    16741 caatgggctg tgcggatcag cgctgcacgc atagctcaat cgaaatatac agtacttacc
    16801 tgagtcccat tgactctgat accgcgagct atcacttgga acattctgcg ccgcctgctg
    16861 acgaccctgg tgaccaccac cgccgccgcc gcctccaaac atatgctcaa agaactggaa
    16921 ctgggcgtga gccacggagg caagtagaag aagggctccg aggagccgaa tccaggagaa
    16981 cattgcgaat ggtgcctaaa caaacaagcg agcaatatat ccaaatcaaa aagcgaagca
    17041 aatcaaatca tcgataaaag ccagcagaga agtatatagt tgtagataac ttaccggcca
    17101 tctggccgca tccggcacgt gaccttaccc gccaagtcca tctccgatcc gcgaaaaaaa
    17161 gcagccccgg aatagagcga gccatctccc tcccccagtt caatcccatt gaacatcatt
    17221 ccccaaccca cacaatgttc caacctcgtc ttctagcgcc cctccgggct ctagaaaggg
    17281 gactcaccag aacccccacc gccgctacca ccagcatccg caacacctcc tcgctcctcc
    17341 gcaacacctc ctccatcctc tccgcaacca gcataacaca aaccaagctc accccgctag
    17401 catctccaac attacaccaa ttcctccaag tccgacacgc ctcccacgcc tctcaaggta
    17461 ccgcgaaccg tcactcccgc gatccggctg gcaagcgtct cggcgcgaaa cgcacagcag
    17521 gcgaatacgt cgtgccggga tgcatcatct tccggcaacg aggcacgaaa tggttccctg
    17581 gcgagaactg cgccatgggc cgcgaccata ccatctacgc tgctgaggct gggtatgtac
    17641 ggtactacct ggaccctgag cgccatccgg atcggaagta cattggagtt gtgtttgaga
    17701 aggagggcaa gttgccgaca ccgaagaatg cgcctactag gcggaagttg aaccgcgtgg
    17761 cggttcggtt tgagcctgag gaggagttgg ccgccaagca gggcgatttg gtggctaaga
    17821 ttggagagga agggacgcag gttggcagtg ctactaaggt tgaggctgct caggctgcgg
    17881 ttcagttgcg tccgggttat atgtaccgtg aggctaactg gagtattggt cgggctgcgg
    17941 agaaggctgg tattacggcc aagccgtata accgcaagaa ccgttggttg gcatggagaa
    18001 agaggacggc taaggctgaa cggatggcac agatgaagag cttgaagaac aagaagaagg
    18061 gcgctaagaa gaagggtgga aaatag
//
