LOCUS       NKJJ01000002.1         13791 bp    DNA     linear   PLN 19-AUG-2019
DEFINITION  Aspergillus niger.
ACCESSION   NKJJ01000002
VERSION     NKJJ01000002.1
KEYWORDS    .
SOURCE      Aspergillus niger
  ORGANISM  Aspergillus niger
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Eurotiomycetes; Eurotiomycetidae; Eurotiales; Aspergillaceae;
            Aspergillus.
COMMENT     'Annotated using funannotate v1.6.0-df4262f'.
            ##antiSMASH-Data-START##
            Version      :: 5.0.0
            Run date     :: 2020-11-02 06:54:43
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 1591612
            Orig. end    :: 1605403
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..927)
                     /NRPS_PKS="Domain: PKS_ER (1-170). E-value: 1.8e-19. Score:
                     61.7. Matches aSDomain:
                     nrpspksdomains_CAN33_24285_PKS_ER.1"
                     /NRPS_PKS="type: other"
                     /codon_start=1
                     /db_xref="InterPro:IPR011032"
                     /db_xref="InterPro:IPR013154"
                     /db_xref="InterPro:IPR020843"
                     /db_xref="InterPro:IPR036291"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028:crotonyl-CoA reductase / alcohol dehydrogenase
                     (Score: 109.9; E-value: 2.3e-33)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="CAN33_24285"
                     /note="EggNog:ENOG41; GO_function: GO:0016491 -
                     oxidoreductase activity [Evidence IEA]; GO_process:
                     GO:0055114 - oxidation-reduction process [Evidence IEA]"
                     /product="Alcohol dehydrogenase GroES-like domain family
                     protein"
                     /protein_id="ncbi_CAN33_24285-T1"
                     /transl_table=1
                     /translation="MRDYNFFLTEYPAVLGSDASGTIAAVGPNVTTFTPGDRVFFQGII
                     GNYAASTFQQYCVMPAELVSRTPSNISDEQAAGISLASVAVVTGMYDSTGHGIAPAPWA
                     EGGDAAGKGKAIAILGGASSVGQYAIQFARLSGFTKIITNASVVHREYLQGLGAHVVLD
                     RKIAKAEDFVAAAGEVPIRYVYDAISMKETQVLGVEIAKASKGAAKAVVTVLGAEKEAA
                     ELGKEGEHQVEVRQILGIGASPKLRHVSEPMVKALGGEDGWIAKGLFVPNRVRVVPGGL
                     GAVEEALKTNKEGVSGEKVVFRPNEGA"
     protocluster    1..13791
                     /aStool="rule-based-clusters"
                     /contig_edge="False"
                     /core_location="join{[1600562:1600892](-),
                     [1600494:1600519](-), [1600259:1600436](-),
                     [1600027:1600184](-), [1599889:1599979](-),
                     [1599806:1599840](-), [1599523:1599747](-),
                     [1599396:1599466](-)}"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(join(7785..7854,7912..8135,8195..8228,
                     8278..8367,8416..8572,8648..8824,8883..8907,8951..9280))
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     cand_cluster    1..13791
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13791
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="8"
                     /rules="(Terpene_synth or Terpene_synth_C or phytoene_synt
                     or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps
                     or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /tool="antismash"
     mRNA            complement(1..927)
                     /locus_tag="CAN33_24285"
                     /product="Alcohol dehydrogenase GroES-like domain family
                     protein"
     gene            complement(1..927)
                     /locus_tag="CAN33_24285"
     aSDomain        complement(418..924)
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CAN33_24285_PKS_ER.1"
                     /evalue="1.80E-19"
                     /label="CAN33_24285_PKS_ER.1"
                     /locus_tag="CAN33_24285"
                     /score="61.7"
                     /tool="antismash"
                     /translation="RDYNFFLTEYPAVLGSDASGTIAAVGPNVTTFTPGDRVFFQGIIG
                     NYAASTFQQYCVMPAELVSRTPSNISDEQAAGISLASVAVVTGMYDSTGHGIAPAPWAE
                     GGDAAGKGKAIAILGGASSVGQYAIQFARLSGFTKIITNASVVHREYLQGLGAHVVLDR
                     KIAKAED"
     CDS_motif       complement(529..576)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CAN33_24285_0001"
                     /evalue="1.30E-02"
                     /label="PKSI-ER_m5"
                     /locus_tag="CAN33_24285"
                     /score="8.4"
                     /tool="antismash"
                     /translation="ILGGASSVGQYAIQFAR"
     mRNA            complement(2511..4577)
                     /locus_tag="CAN33_24290"
                     /product="hypothetical protein"
     gene            complement(2511..4577)
                     /locus_tag="CAN33_24290"
     CDS             complement(2511..4577)
                     /codon_start=1
                     /locus_tag="CAN33_24290"
                     /note="EggNog:ENOG41"
                     /product="hypothetical protein"
                     /protein_id="ncbi_CAN33_24290-T1"
                     /transl_table=1
                     /translation="MGYIARTDDLPDIARKGGLVDPRAEDQPLFFERMSCRDVNEFVSN
                     PANVSPLSSGNPSAATKPTSLGMRLRQPAIQSQARIDEFRARSEEIKQRMPIRNAKQPI
                     SDLVPDLVVTGGLSRSPAFDCLPVFSHWADRTGELSATDLAATVRLTSTWGTAHVAAEG
                     VNMDAPRGAHAWSLKSHGIGPAEPGASKFSQQYDADTDTLTTTVNVARRLDTPRTDGVL
                     GAVSSVSWMRNARVADAVDCAAGLLSDASTLLEARDRMIATGAPEHVGFAEVRPVDMPS
                     WCSARKPLAPKLSGVAVASDPTAVNLFAGEDCQGPMLNTSVFAMTSGYNRGVYGGSISG
                     LWSTMDASFVMDYSIGVHSAAMADKLSIAFADAAAAAEKSAYAGAHITDISLVKGCNYS
                     CLRQKTVIEDSHPIPSRPTIVVWNDLARLARYKLADAVFCHVYYDGGGSEHMAAIAGLG
                     CVAHDWIDLGADVACGEVSNIIPSLTRGSLEEAPLAEVYARIIGAMIWYRDNDPYNPAA
                     NCLLFTHWWQLSNCRHRPVTLLGRTDLPVDAGIVPIVPDERPPLEHFRANGTKVERGAR
                     ALANAEARLEALIASDPLPETRAVIDLLVKPVLAYVKGGDTLPSENEYVGATLAAQVAY
                     PQNQKILEMWDLAIVMWECGALWASGVAGLCYTHAGLSNCDRARKDLSDTTWS"
     mRNA            complement(join(7785..7854,7912..8135,8195..8228,
                     8278..8367,8416..8572,8648..8824,8883..8907,8951..9280))
                     /locus_tag="CAN33_24295"
                     /product="Terpene synthase family metal binding domain
                     family protein"
     gene            complement(7785..9280)
                     /locus_tag="CAN33_24295"
     CDS             complement(join(7785..7854,7912..8135,8195..8228,
                     8278..8367,8416..8572,8648..8824,8883..8907,8951..9280))
                     /codon_start=1
                     /db_xref="InterPro:IPR008949"
                     /db_xref="InterPro:IPR034686"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: Terpene_synth_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052:Terpene synthase/cyclase metal-binding domain
                     protein (Score: 139.6; E-value: 2.5e-42)"
                     /gene_kind="biosynthetic"
                     /locus_tag="CAN33_24295"
                     /note="EggNog:ENOG41"
                     /product="Terpene synthase family metal binding domain
                     family protein"
                     /protein_id="ncbi_CAN33_24295-T1"
                     /sec_met_domain="Terpene_synth_C (E-value: 4.8e-10,
                     bitscore: 35.6, seeds: 87, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MEQRQKLRGLLKGQCAVLPNLYSLFPDWSPELHPEYTRARDDSTN
                     PWIKRCVDFDKFLAIHFSVLLSDSFAKNPVICRKLQEADFTTFAAVMCAKSSFEQLCTL
                     AKWFTWYEYFIWDDLFDCGSLTHDPENIKRYKHTSIEYFKHVLCHEAEHPDLSEFSEEL
                     QNALRCWDEIAEHVLTRKVLLAAMIDYVSSVDGVDSIYSEGEIPSVQQYWRRRDRTAGV
                     HPVIATIPFIYDIDISTRDMDDTHMKLLRRHTSYLVHIQNDMFSLRKETRVGQVENLVP
                     IIMLNENLRASQAMKVAFMFAQESARGFDEVVDDMRQTAKGRRRAVADIFIKGCRNIVM
                     GLTHWSYTGERYFRAGEADENHTIYFEL"
     mRNA            join(10033..10869,10934..11048,11104..11396,11457..11912)
                     /locus_tag="CAN33_24300"
                     /product="hypothetical protein"
     gene            10033..11912
                     /locus_tag="CAN33_24300"
     CDS             join(10033..10869,10934..11048,11104..11396,11457..11912)
                     /codon_start=1
                     /db_xref="InterPro:IPR008930"
                     /locus_tag="CAN33_24300"
                     /note="EggNog:ENOG41"
                     /product="hypothetical protein"
                     /protein_id="ncbi_CAN33_24300-T1"
                     /transl_table=1
                     /translation="MSSSILVQCAKELIAKVASESKSQYGFSSMAPSIYDTAWLAMVEK
                     RTDEGYEWLFPTSFEYLLREQTNDGGWDALESVARRHREYPENIWIQDCVIHSLAALHA
                     LCRHVRRSSSHHREPLPDDILFRLFRAKSFLDAKLQKWQPDDSIHFTVELIVPVLLHLL
                     YEEGVDFQFPAKDDLLSKYTAATSVDLRWLYQGPCSIPLFSLEGFARQLEWDKLECLVT
                     SSGITASPASAAAYLIFSPNWSDECEAYLRHIVSHGQGKGNGGVGGVYPLEVFEPCWVL
                     STLLDSGFTVENLGAQNVGDLVELIHRSISNGVTGATHTFFPDADDTARALMVLNNNGY
                     AVSRANLIRKFECDDGFETFDDRMPQRVTSVSVNGNVLSCLLSSSDPSAFTPQIENIAK
                     FMCTKWSKEKTLHDHWNLSEYYGIMHIAQSLVPVRVLWDQGCIPGLAEDIVEKHISTCL
                     REVVDRVLRGQNDDGSWGNMHGAEETAYAIIALAQLASHADIVSDYSKADLAIARGKQF
                     LLETWTMGQKPDRIWTGKVLHGISYVHDAHVLAALKINRANLAGKRGFF"
     mRNA            complement(join(12713..12978,13054..13456,13531..13791))
                     /locus_tag="CAN33_24305"
                     /product="Aldo/keto reductase family protein"
     gene            complement(12713..13791)
                     /locus_tag="CAN33_24305"
     CDS             complement(join(12713..12978,13054..13456,13531..13791))
                     /codon_start=1
                     /db_xref="InterPro:IPR023210"
                     /db_xref="InterPro:IPR036812"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039:aldo/keto reductase family oxidoreductase (Score:
                     80.9; E-value: 1.5e-24)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="CAN33_24305"
                     /product="Aldo/keto reductase family protein"
                     /protein_id="ncbi_CAN33_24305-T1"
                     /transl_table=1
                     /translation="MSESNPLHPTLTLPPIILGGSGFSDQSHPNPQTLPVATIIRRAFD
                     EGILAIDTSPYYHPSEHLLGTALSDPQITTRYARSDYILMTKRLHTTYLDVVFCHDVEF
                     VSEHEAVEAVGVLFDLRRQGYIKYVGISGYPLETLVSVAHAVRHVYGQPLDVVQTWAQL
                     TLQNTKLERYGIPALREAGVSVVCNSSPLASGLLRAGKVPCGRLGDWHPAPEGLRSAVT
                     VRAADRYAVSVSTVLGVSSLKDVEEDVEVARDILRDLDAGLVYKRMEVMGGLSRLRRVN
                     EEVECRDLRLCYGVRNILGEWAEYDLQK"
ORIGIN
        1 ctacgcaccc tcattgggac ggaagaccac cttctctccg gaaaccccct ccttatttgt
       61 cttcaacgcc tcctcaacag cccccaatcc accaggaacc acgcgcacgc gattcggcac
      121 aaacagtccc ttcgcaatcc atccatcctc acctccaagc gccttcacca tgggctcact
      181 aacatgtctc aacttgggag aagccccaat acccaaaatc tgcctaacct ccacctgatg
      241 ttcgccctcc ttccccaact ccgccgcctc cttctccgca cccaacaccg tcaccaccgc
      301 cttcgcagcc cccttacttg cctttgcaat ctccaccccg agcacctgcg tctccttcat
      361 cgaaatggca tcatacacat aacgaatcgg cacctcccca gccgcagcaa caaagtcctc
      421 cgccttggca atcttccgat ccagcaccac atgcgctccc agcccctgca aatactccct
      481 atgcacgacg ctcgcattcg taataatctt cgtgaacccg ctcaaccttg caaactgaat
      541 cgcatactgt cccacactcg acgctccgcc caaaatagca atcgccttgc ccttgcctgc
      601 cgcatcaccg ccctcggccc agggagccgg tgcgatcccg tgccccgtgc tatcatacat
      661 tcccgtcacg acggccacgc tcgctagact gatccccgcg gcttgctcgt cggagatgtt
      721 ggagggggtt cgcgagacga gctctgccgg catcacgcag tattgctgga aggtcgaggc
      781 ggcatagttg ccgattatgc cttggaagaa gacccggtcg cccggggtga aggtggtgac
      841 gttggggccc acggcggcga tggtgccgga ggcgtcggag ccgaggacgg ccgggtattc
      901 ggtcaggaag aagttgtagt cgcgcatctt ccagtcgacg gggttgacgg ccgtggcggt
      961 gatttttatg aggacttcgt tggcgttggg ggtgggcacg gggtgggtgg ttagggtgtg
     1021 gggtgattgg gggtgggcac ggtggccgcg aggtaggtgt cggggaggga cattgtggtg
     1081 gttgtggtgg tggtggtatt gttgttggat tgaggtggaa gagtgtggtt ggtggaaagg
     1141 gaaataaggt gctgacgggc gttgtttgat atgaggatca gattatagct cgtgaggggt
     1201 ggtactttga tttggatgat gaggttatat agggatccag tgtctgattt gtaatgaggt
     1261 catggacatt agtcatcgac tccactgggg cattaatctg gggtgtgctt tggttatgcg
     1321 gtgcatgtta tggatagggc aatggtgttt tgggtttagg gaagctggga gaggcctgtt
     1381 ttcaaggcat gaacatggct gcaagctgta gaaagcaaat gtgtcatgta gaagttgtaa
     1441 aagtcactga cattaattgc ctatcgaaaa cggttgagcc aaagagtaac cagtcttcaa
     1501 atgcgtgacc aatgcgtaac atagtataac ccaattagca gtaactgtcc aagtacttct
     1561 agtactttcc atcatgcatg gatctctttt aagtggtgag tgaaactggt gccttggtct
     1621 taacttgcgt ccggatctgc ggcaagcatc tgcagtcaga tagcgtcttt cctcttttgt
     1681 taatcttcgc atataagcca tgcagcccaa catggtcaat ggaacagtag catagcatca
     1741 tcttcttcaa gaaaaaagaa agaaaaaata atcataatat aatacgctct gaccgtcatc
     1801 ctagcaattg aagggaattg aagatgctca atctgcccag tgagggtgtg gctatactac
     1861 tgagtagtag gttcggagtt tatcttcaat gactgctagc agcagatata tacttcggat
     1921 gaatgagttg aatgcgaatc acacgatgtc tacttctact actcagcgag tactattgca
     1981 gaagcagtct gtacttcagg gttgggaaac tgtaacagtg aactaggtag gaaaaaatga
     2041 tctaaaagat agataaaagg attgatgata ataattatac tattgaggtc aaagatcgat
     2101 cttctgtttt tagtgtggct tgacgtggaa gcttagcagg taactaacaa catttgagga
     2161 aatttacagt acggcatgtc atagacttac cgcctaaccc gttccggaac acaggcccta
     2221 agtgtgcctg aggctgggat gttgtatctt cgtcgaactt gtattcaggg tctacagctc
     2281 gcacaaccct gtgaattcat aaataaatga aaaaacgctt ccgattctta acctgattat
     2341 caatctaacc tagtctagaa tagagtaaac gctatgtaag cgcatgaggg tcgtaagtgg
     2401 tagagactga tataaagcaa ttctttgtat gagacgccac ataaagttcc tttcatgctg
     2461 tctgaaagcc agctcatcct gttgacttgc attgtatttt ggcacaaggt tcaactccaa
     2521 gtagtgtcag acaggtcctt acgagcccgg tcacagttgg acaacccagc atgagtatag
     2581 cagagtccag ccactccgga cgcccacagc gcaccacact cccacatgac gatagccaga
     2641 tcccacatct caaggatttt ctgattctga ggataagcca cctgggcagc gagggtagct
     2701 ccgacatatt cattctccga gggtagggta tcaccgccct tgacgtaggc gagaacaggc
     2761 ttgacaagga ggtcaatgac agcacgggtc tccggcaagg ggtccgaggc aatgagagcc
     2821 tcaagacgtg cttcagcgtt ggcaagcgca cgcgcaccgc gctcgacctt ggtgccgttt
     2881 gcccggaagt gttccagagg aggtctctcg tcggggacaa tggggacgat gcccgcgtcg
     2941 acagggagat cagtccggcc gaggagagtg acggggcggt gacgacagtt ggagagctgc
     3001 caccagtggg tgaagaggag gcaattggct gctgggttgt agggatcgtt gtcgcggtac
     3061 cagatcatag cacctattat gcgggcgtaa acctcggcca gtggggcttc ctccaaggaa
     3121 cctcgtgtca atgaagggat gatgttactg acttcaccgc acgctacgtc ggctccaagg
     3181 tcaatccagt cgtgcgcgac gcagcccaga ccggcgatgg cagccatgtg ctcgctacca
     3241 cctccatcgt agtagacgtg acagaacacc gcatcggcca acttgtaccg ggcaaggcgg
     3301 gccagatcgt tccatacaac gatggtagga cgagaaggga tcgggtggga atcctcaatg
     3361 acggtcttct ggcgcaagca ggaataattg cagcctttga caaggctgat gtcggtaatg
     3421 tgcgcgccgg cataagcgga cttttccgca gcagcggccg catcggcaaa agcaatggag
     3481 agtttgtctg ccatggcagc gctgtgaaca ccgatggagt aatccatgac gaaagatgcg
     3541 tccatggtcg accacaagcc agagattgaa ccaccgtaga caccacggtt gtaaccactt
     3601 gtcatggcaa acacactggt gttgagcatg gggccctggc agtcctcccc ggcgaacagg
     3661 ttgactgcag ttggatcaga tgcgacggcc acgccactca gtttgggtgc gagaggcttg
     3721 cgggcagagc accagctggg catgtcgacg gggcgcacct cggcaaatcc gacgtgctca
     3781 ggggcgccgg tcgcgatcat tctgtcgcgg gcctccaaaa gagtcgaggc gtctgagagc
     3841 aagccggcgg cgcaatcgac ggcgtccgca acacgtgcat tgcgcatcca tgagacactg
     3901 gagacggcac ccaaaacacc atccgttcga ggagtatcaa gacggcgcgc cacgttaaca
     3961 gttgtggtga gggtgtcagt gtcggcgtcg tattgctgag agaacttgct tgctccgggt
     4021 tcggcagggc ctatgccgtg agatttgagt gaccaggcgt gagctccccg aggggcgtcc
     4081 atgttgactc cctctgccgc aacatgggcc gtgccccagg tggaggtaag ccggacggta
     4141 gcagccaggt cggtagcgga gagctcgcct gtgcggtcag cccaatggga gaagacaggc
     4201 agacaatcga aagcgggcga gcgactgaga ccaccggtga ccaccaaatc cggtaccagg
     4261 tcagatatgg gctgtttggc gtttctgatg ggcatacgct gtttgatctc ctcggagcgt
     4321 gcgcggaatt cgtcgattct ggcctggctc tggatagctg gctggcgcaa ccgcatgccc
     4381 aaactagtgg gcttagtagc agcgcttggg tttcctgagc tcaatggaga tacattggcc
     4441 ggattggaaa cgaactcatt cacgtcccga caggacatgc gttcgaagaa gagaggctga
     4501 tcctcagccc gggggtcgac gagacctcct ttacgagcga tgtcggggag atcatctgtt
     4561 cgcgcaatgt agcccatctt gaaaagatgt ttgaggaacg atgtggtctc tcgggaaaaa
     4621 gaatagctta agggagatag ttgatgggaa ttaagttgct cttatagagc gaagagagat
     4681 aacaaaaggg aaaggaagac tcttggattc acgtctccag gtactctcga gactaggact
     4741 tttcttgaag ccagttatct ctgagctgcc tgagttgatt tctgtccatg accacgctca
     4801 ttgttggacc tttttatata gatcgagaga gggtagatta acacgggcca cagccgttcc
     4861 tccgttcagc ccaactcagg ccagagacac aggccagcct gcgagccatg attcaggaac
     4921 cacttggctg caggcccgct cagccagcct ccattgcccg agtgaagcgt gtcagacata
     4981 agcccaaact caattatttt ggcagattcc gcgggctctt cctcctgggg gagggcgggg
     5041 gagatacgac agcctcactg aattttaata cctgataaag ttgaattgct gaccaagatt
     5101 atccccttat acagcattct caattgacac cagaaaatgt aaagaacaaa agaccccccc
     5161 ccagaaaagg gaaataagat atgactcaaa atgaaaatat gtctctaatt caataaacag
     5221 gagaaacaga catgtaaccc ttctccatga gtggtgtttc ccgtcgaagc gttcttccac
     5281 caccaaagag ccgaaccgct aactccactc attatgcgct ggcattttct ccccgccaga
     5341 ttaaaacgta ctaagcgtag tgctctgcca cttggaacga cagcacaact ccaccttcat
     5401 tacccctgtc ctgcagactg tcatgatctt attccccgct gtcagcgcag attcagctca
     5461 gccaatctct ccctattccg cggatgatcg ggaccaatcg gaaatgaaga gcatagtccc
     5521 gtgtactact cgtcatcatg gtacccgatc gtttcgattt ggctccctaa cctatcgaat
     5581 cgttccactg tcgattccgt accgatgcac acacgcattg gctttggcca cttggcacag
     5641 ccccctttgc ttcccttggc gcttcaagat gatggtcgca ttatcctact cgcaaaagtc
     5701 tgcagtatat gcaatgtatt ttctcttgaa tgtgccttct tccatgcagc agattcggac
     5761 gtaactgaga acgaaacctc tgatcaacac cgtatgagct tgtttcctat ctcaaatgat
     5821 atgccaccag tttctcggtc accccgctta aggctgaagc caagaaagac caccagctga
     5881 tatgcgacta gatgttaggg cgtgcatgcc ttgcatctct ttgacatatc ggatttctca
     5941 acccttccac ccgctccccg gacttatatg aacgttcacc tggatcccta tcacggtcta
     6001 caggggaagt agatcttcat ccactcatac gctctccata agcagacatt tgccaccttg
     6061 cctgaccatt gcacaatata ctagttcgct aaagttaata taccgcggaa cttgcgatga
     6121 tcaagccata tgcgcctacg cccccactct ttcaaagtgt tgagagatat aattgccctc
     6181 aaacctcagc tgatctgaaa ccgccaccaa atataatcgt tgactcctta tgtgaccaag
     6241 tcgacgagct ccataaccgc tctaaccgca gactttaacc tgaccggtct ttgttctcgg
     6301 gcaagataca aaccagccta gcccacactc ttggtcttac gaattattca tcctatctac
     6361 actcatgttt tcagcatacg tatgctcctc agcgttctgc tttctggcgc ccacaccggt
     6421 cctttgctta accggtcttt tgatcatcat cttgatgtca cttctctttc gcttcattct
     6481 cagaacagac aaggtcgaaa atataccccg tgatgcgata atggggaggc gacgtattcg
     6541 acacggaaat gctacccata gtatatggag cttatgaggg attagttggc cacttaaggg
     6601 ttccacaaat gtaccccacg ctgtaagctg taccggacac ttcgccattt cgtctagcat
     6661 gcttagatga catttccagc cctagaatct cttcgcacaa tgaaggagga agatacaggg
     6721 attacccact atccacacaa gtctacaatc tcgttcgctg gtctttcatc cgaactccag
     6781 gagctgtcct cgggaaccac gaagatttat gagtcatgat tgaaggattc tatgtttttg
     6841 tactttactc cctatgatat gctctgcgtt cttacctgtt cgttataaat atttccagaa
     6901 tgtacactcc ccttgacgta tgtcaactgt accagaacat acttctagga cattctaatc
     6961 acctgaatgt atagaacgat cagtaatgta ccacacattt aattcaagca tccacccatg
     7021 taataaaaca ctccggtggg cagcctcagc ccacgacgtg actaagttcc aggaaactca
     7081 gctggcaagg gatgttacat ctgaccagta agcctacacc acatactgcg tctgtcagct
     7141 tagactatcc actggcagga aagctaagca ctaaaatcaa ttcagaaacc atactcgtga
     7201 taatgtcatc ccttgtagtt tgctgtcaaa tcaagatttt gttcatgtgt cccttcatgc
     7261 aaccaaagat tttgccggga taacggaatt gttctgcggt cgaaatttct tatttgttgt
     7321 ctgtgcatgc atgattgata tacgatgagt gacggtactg cataacatat gcatattatt
     7381 ccacatctgc catttttcag gttgttgatc agcctgcgcc acaaatcccc cacttccgcg
     7441 gaggttatca tcccttgctt tttgaaagat ggggggtgtg cgtggaattc ttgttgtgat
     7501 ccaatcagtc ggtgtggaat aagatcttga agagatgaac tgaagcaatg attgacgttt
     7561 cggatgcttc ggtgaaactc aaaataatgt cttcttactg cacataaact ttgtgtagat
     7621 tgctgtctaa gaatgtaagg gtagtcgctg aggtgatgat gcgagatcat ccctatgagc
     7681 ctgacgcctg actttcgtcc gtgaaacacc aaaggaaggc gctgcaacta ctctgaacga
     7741 gtggaataag atcgcaaatg gcatatagaa aaggaacacc cagcctacag ttcgaaatat
     7801 atggtgtggt tttcatccgc ctcaccagct cggaaataac gctctccggt gtagctagaa
     7861 aacaacatca gtaaagcgca gggcttatca ataagtctat tgtgaattta cctccaatgg
     7921 gtgagcccca tgacgatgtt tctgcagcct ttgatgaaaa tgtctgcgac agcgcggcgt
     7981 cttcccttgg cagtctgccg catatcatca accacttcat cgaagcccct tgctgattct
     8041 tgagcgaaca tgaaggcaac tttcattgcc tggctggctc tcagattctc gttcagcata
     8101 atgattggaa caaggttctc gacttgtcca actctctgtt acacaaatgt tagctatgtg
     8161 caacattcca acaccttgac aggcacgtat ttaccgtctc ctttctcagc gaaaacatgt
     8221 cattctgtct gtgacaactc ggttaaagtc ctggatccga catcagagcg gacttacatg
     8281 tggacaaggt acgatgtatg tctccggagt aatttcatat gcgtatcatc catatcccgc
     8341 gttgaaatat caatgtcata gataaaacta taaaaatgtc agccacagct cgacaaaatg
     8401 tttgagaaga catacggaat agttgcgata actgggtgga cgccagctgt gcggtctcgt
     8461 cggcgccagt actgctgtac tgagggaatt tcaccctctg agtagatcga atccacccca
     8521 tcaacactcg acacataatc tatcatcgcc gctaacagaa ccttgcgcgt cactaaattc
     8581 cagactgtca atattggacg aaagcaaacc attgggacgt aagacattct ttttgagcac
     8641 acctgacgca catgttctgc tatctcgtcc cagcagcgta gcgcattttg gagttcctcg
     8701 gagaattcag ataaatccgg atgctctgct tcatggcaaa ggacatgctt gaaatattca
     8761 atactagtat gcttgtacct cttgatattt tctggatcgt gggtaaggga gccgcagtcg
     8821 aaaacttgag gggtgtttca gttcagtata acattagtaa gtagcagatg ggaaatccat
     8881 acgatcatcc catatgaagt actcgtactg ttattagtaa acatcagaag atcttggttc
     8941 acacacctac ccaggtaaac cactttgcca acgtacagag ttgttcaaag gacgattttg
     9001 cgcacataac tgcggcgaat gtcgtgaaat ccgcttcctg aagcttccga caaattacgg
     9061 ggtttttggc aaagctgtct gacagtaaga ccgagaagtg tattgctagg aatttatcga
     9121 aatcgacgca ccgtttgatc cacgggttag tagaatcatc ccgggccctt gtatattctg
     9181 gatgcaactc tggtgaccag tctgggaaca aggaatagag attaggtaga acagcacact
     9241 gtcctttgag taagccacgg agtttttgac gttgctccat ggcggattgc ttgttctgtt
     9301 cgacctggct tcgatgaccg tttattcaat atgaatgtat tagctataat cacgactatt
     9361 atgcagtatc actagtctta tgtatttata ggtatcaagg gccagcacag ccacctaggt
     9421 actgcaaaag ccacggccat atagagttcc tagtatatca gtcaaaacca tatcgtgctt
     9481 tcaaatgcac ttaatacgct agttgtacta atccagctga tgtgactgag acatatgctt
     9541 tagatctgct ttctgaagta catatttaac aaactcagat cagacgtgat ggcttgattt
     9601 cttcacacgt gcctcggtgc ggttacacgg cgtagatgca tctacccctt gtttcggtga
     9661 gcccggtgtc cagtcaatgc agtcaccagg cagaccactg ttaaaacaat cctagtggct
     9721 tagggttttc atcatttaga agcaccgcag ttgaactgga gttgtgctac tgtgagcccc
     9781 tcataccttg cagaccacac cagagcggtc aggagtttac aataaatagc taggggacta
     9841 cttcgatcgt gactgctgta gaaagaaaga tatattggcg caaggctcta gatctcacat
     9901 aaagcatatt agtccaggac atcaacattc cgtgaaagtt tgtttatata atttcttttt
     9961 tgatttcatt tctattcttt caggtttcta ttgcttactg atagcttatc ccacaagctt
    10021 ttgaagtcaa atatgagctc ctctatacta gttcaatgtg ccaaagagct catcgcaaag
    10081 gtggcctctg agtcaaagtc acaatatgga ttttcctcta tggctccatc gatctatgac
    10141 actgcatggc tggccatggt cgagaaaaga acagatgaag gatacgaatg gctctttcca
    10201 accagcttcg agtatctcct gcgcgaacaa acgaatgatg gtggttggga tgccctcgaa
    10261 agcgtcgcca gacgacacag agagtatccg gaaaatattt ggatccaaga ctgtgttatc
    10321 cattcgttgg ctgcccttca cgccctatgt agacatgtcc ggcgttcttc atcacatcac
    10381 cgagaaccac tacccgacga tatcttgttt cgactcttcc gtgccaagtc gtttttagat
    10441 gctaagctgc aaaagtggca accagatgat agtattcatt tcacggttga actgatcgtt
    10501 ccggtcctac tccatcttct gtatgaagag ggtgtagact ttcagtttcc tgcaaaggac
    10561 gacttgttga gcaagtatac cgcagcgact agcgttgacc ttcgctggct atatcagggc
    10621 ccctgcagca tccctctgtt ttcgctggaa gggttcgcga gacagcttga gtgggacaag
    10681 ctggaatgtc tcgttacttc ttcgggtata acggcttctc cggcctctgc ggcggcatac
    10741 ctaatattct ctcctaactg gagcgatgag tgcgaggcat atcttcgtca cattgtgtcg
    10801 cacggccaag ggaagggaaa tggtggggtc ggcggggtat atcctttgga ggtgtttgag
    10861 ccctgctggg taagttgcat tcaaggatgc gaggaagggc tactagggtt accgctaaca
    10921 cttcatccta taggttttgt caaccctgct ggacagcggc ttcacggtcg aaaacttggg
    10981 agcacagaac gtgggtgacc tggtcgaatt gattcatagg tctatttcga atggcgtgac
    11041 cggtgctagt aagtataatt caggccaaat ttctgccgca gtggatatat agtaatcctc
    11101 cagcccatac cttcttcccc gacgcggacg atacagcacg ggcgttgatg gttctcaata
    11161 acaatggcta tgcagttagc cgtgcaaatc taattaggaa gtttgagtgc gatgatggct
    11221 tcgagacttt cgatgaccga atgccccaac gggtgacaag cgtaagcgtc aacggaaacg
    11281 tactaagctg cctcctttcc tcgtccgatc ccagtgcctt caccccacag atagagaata
    11341 ttgccaagtt catgtgcaca aaatggagca aagagaagac cctccacgat cactgggtac
    11401 ctgcgctgaa atgagctcca catctgtcta ccacagcact aaccgctgta ctttagaact
    11461 tatccgaata ttacggtatc atgcacattg ctcaatcact cgtcccggtc agagtcctct
    11521 gggaccaggg atgcattcca ggtctagcag aagatatcgt tgaaaagcat atatcgacat
    11581 gtctgcgaga ggtagtggac cgtgtccttc gtggacagaa tgatgatggc tcctggggca
    11641 acatgcacgg cgctgaggag acagcatacg cgatcattgc gcttgcacag ctagcgtcgc
    11701 acgctgacat tgttagtgat tacagcaaag cagacctggc cattgctagg ggaaagcaat
    11761 tcttgttaga gacatggacg atgggccaga agccggacag gatctggacg ggtaaggttc
    11821 tgcatggcat atcatatgtg catgatgcgc atgtgcttgc tgctttgaag attaatcggg
    11881 cgaatctggc tggaaagcga ggtttcttct gactggtgtc ctcaaaactg tgcatgatga
    11941 ggaatacgta ctctggcgag cacatcacgt tatttctggt tggcagtaaa aatgactatg
    12001 catattggtc ccagtggtta ctaagatctg aagtaagcta cctgctcgag atgaattaag
    12061 catccaacat cagtgaaacc tacgaggacc agaaagtgca tgattacgcg cagttgggag
    12121 tgtgcgcact taagtctaaa ccatcactag aagcgattat ttccaagttt tgaattgacc
    12181 ttaagaagta ttttaccctg cttgttgatc tgatagaaga tatgagtcct ttccttaatc
    12241 cgacctgcct tggtcgttag ccactctact actaggtagt tagtctagat agaagattat
    12301 atcatctagg tttagctttc ctagcttgag attaaatctt ccctatttca gatatagtaa
    12361 tagaattata gaagtagtta cggaagatgc taggattatt caagaggtat tctatgtagt
    12421 tagtaattga ctgttacttt ctcttcaatc agaccaggca gatatataac tatccacaaa
    12481 attttcatta ttctgggaag gtagttattc aagtcccatg aacatgggtt cagccctatt
    12541 gctactgcag tgttgtactt attcaaggca tgcacgtagt gttgcagttc gtctttgtct
    12601 tccacgaatc tgatgtaatc tacacggtac tgaatgatgc tgacaagata gaacaggtca
    12661 aatatatctg tctatatatt ctatatcaag gtcctactta tacagcaatg tcttatttct
    12721 gcaagtcata ctcagcccat tcccccaaga tgttccgcac gccataacac agccgtaaat
    12781 cccgacattc aacctcttca ttcacccgtc gaagacgcga caggccgccc atcacttcca
    12841 tccttttata cacaagccca gcatccagat cacgtaaaat gtcccgggca acctccacat
    12901 cctcttccac atccttcaag gacgataccc ccaggacagt agagacagag acggcgtatc
    12961 tatcggcagc ccgcacagct ttcgccaacg aaaaccgcaa cgccaacccc gccaacccga
    13021 acccctgaca ctccaaccaa cccgaagcga tactcacagc gctcctcagc ccctcaggcg
    13081 caggatgcca atcccccagt ctcccacaag gcacctttcc cgcacgcaac aacccggagg
    13141 caagcggact cgaattacaa accaccgaca ccccagcctc acgaagagcc ggaatgccat
    13201 accgctccag cttagtgttc tgcaatgtca actgagccca ggtctgcacg acgtccaatg
    13261 gctggccata tacgtgtcgc actgcatgcg cgacagagac tagcgtctcg agcggatagc
    13321 cggagatgcc cacgtacttg atatagccct gtcggcggag gtcgaagagc acgccgacag
    13381 cttcgacggc ttcgtgctcc gagacgaatt ccacgtcgtg gcagaagact acgtctagat
    13441 aggtggtgtg taggcgctcg agggagttgt ggactgattg gcggacccag gtggggaata
    13501 gtcaaaggcg ctggtcgaga ggcgcccgac tttagtcatg agaatgtagt cgctgcgtgc
    13561 gtagcgggtt gttatctggg ggtcggagag ggcggtaccg aggaggtgct cggaggggtg
    13621 gtagtagggg gaggtgtcga tagcaaggat gccttcgtcg aaggcgcgac ggatgattgt
    13681 tgcaacgggg agggtttgtg gattggggtg ggattggtcg ctgaagcctg agccgccgag
    13741 gattattgga gggagggtta gggttggatg gagtggattt gactcggaca t
//
