LOCUS       NKJJ01000011.1         18636 bp    DNA     linear   PLN 19-AUG-2019
DEFINITION  Aspergillus niger.
ACCESSION   NKJJ01000011
VERSION     NKJJ01000011.1
KEYWORDS    .
SOURCE      Aspergillus niger
  ORGANISM  Aspergillus niger
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Eurotiomycetes; Eurotiomycetidae; Eurotiales; Aspergillaceae;
            Aspergillus.
COMMENT     'Annotated using funannotate v1.6.0-df4262f'.
            ##antiSMASH-Data-START##
            Version      :: 5.0.0
            Run date     :: 2020-11-02 06:54:43
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 554172
            Orig. end    :: 572808
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..18636
                     /aStool="rule-based-clusters"
                     /contig_edge="False"
                     /core_location="[562723:563680](+)"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      8552..9508
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     cand_cluster    1..18636
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..18636
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="4"
                     /rules="(Terpene_synth or Terpene_synth_C or phytoene_synt
                     or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps
                     or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /tool="antismash"
     mRNA            join(1..131,191..221,285..422,479..779,892..1038,
                     1171..1937)
                     /locus_tag="CAN33_17070"
                     /product="Flavin containing amine oxidoreductase family
                     protein"
     gene            1..1937
                     /locus_tag="CAN33_17070"
     CDS             join(1..131,191..221,285..422,479..779,892..1038,
                     1171..1937)
                     /codon_start=1
                     /db_xref="InterPro:IPR002937"
                     /db_xref="InterPro:IPR036188"
                     /db_xref="PFAM:PF13450"
                     /locus_tag="CAN33_17070"
                     /note="SECRETED:SignalP(1-24); GO_function: GO:0016491 -
                     oxidoreductase activity [Evidence IEA]; GO_process:
                     GO:0055114 - oxidation-reduction process [Evidence IEA]"
                     /product="Flavin containing amine oxidoreductase family
                     protein"
                     /protein_id="ncbi_CAN33_17070-T1"
                     /transl_table=1
                     /translation="MHTIPITVSLYAFLATTFLFSCSAYVAQAPLSDDKCTETTVAILG
                     GGMAGIAAAQALSNASIDDFIILEYRDTLGGRVWHTDFGKDKQGKPYVIELGANWLQGL
                     GSEAIENPVWALAKKYRLKNTYSNYSSIRTYNETGYTDYRYLLDEYAQAYHIAARDAGR
                     ILTQNLQDQTARTGLALAGWRPRKNDMAAQAVEWWSWDWEDAHTPETSSLVFGIAGENL
                     TFNQFGKANHLVLDPRGYSTIIQNEALAAYAICTFSLGVLQNKAVTFDPPLPSWKQTAI
                     EKFNMGTYTKIFMQFPETFWPTDTQFFLYASPTTRGYYPVFQSLSTENFLPESNILFAT
                     VVDEQAYRVERQSLTQTKDQILNVLREMFPDKHIPEPTAFTYPRWTNEPWVYGSYSNWP
                     AGTTLEMHQNLRANTGRLWFAGEATSAAYFGFLHGAWYEGRDAGENVAALLQGRCVEDV
                     STTSTASGKEEKEEACGERVFYEQLNGTTPLDAYSRLNGWPAVSYY"
     tRNA            2079..2150
                     /locus_tag="CAN33_57320"
                     /product="tRNA-Arg"
     gene            2079..2150
                     /locus_tag="CAN33_57320"
     mRNA            complement(2573..4108)
                     /locus_tag="CAN33_17075"
                     /product="major facilitator superfamily protein"
     gene            complement(2573..4108)
                     /locus_tag="CAN33_17075"
     CDS             complement(2573..4108)
                     /codon_start=1
                     /db_xref="InterPro:IPR011701"
                     /db_xref="InterPro:IPR020846"
                     /db_xref="InterPro:IPR036259"
                     /db_xref="PFAM:PF07690"
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 73.2; E-value:
                     2.3e-22)"
                     /gene_kind="transport"
                     /locus_tag="CAN33_17075"
                     /note="EggNog:ENOG41; GO_component: GO:0005887 - integral
                     component of plasma membrane [Evidence IEA]; GO_process:
                     GO:0055085 - transmembrane transport [Evidence IEA]"
                     /product="major facilitator superfamily protein"
                     /protein_id="ncbi_CAN33_17075-T1"
                     /transl_table=1
                     /translation="MATCTEKYSPTPTEVFQDHIASNESDTATLSWDDDNDPENPYNWS
                     VGRKWTLTCLAAFTTFLAMMNGTIITVAHFEISEHFHVNEDAFPNSYWPVTTWATGGAC
                     SALFILPLAEDFGTRPIFLTTYLLFICFLVPQAVAHNFATLVVTRFFAGGCVAILANTA
                     AGVVGNLWSTEWSRSIPVSLYILGYMSGSSTGPVIGAAIFHSLGWRWISYMQLIWFGAL
                     FPIYYFFLHESRGSAILARRARRNRKNGDETSGYAGSGDVSSRLNLHSLVVSATRPVIL
                     FSTEPVLFVSTLWSAFTVGTLFLFTQSVEQVFMGLYNWDVSQTGYVQCAIVIGECLGWL
                     VNFLSRKLYFASASRNTEVPGTPIPEARLYMAVVGGVLGLSGGMFIYAWTSYSSLPWIA
                     PTVGLALVGAGSVCVVTGVSDYVVDSYSQFSGSAMGAVAAGENVFSAFLPLATMSMYRV
                     LGYQWASTLLAFICLVLSLIPTLMFVWGKEVRARSAFMNEMANDATKKRSEVV"
     mRNA            complement(5893..7158)
                     /locus_tag="CAN33_17080"
                     /product="Cytochrome P450 family protein"
     gene            complement(5893..7158)
                     /locus_tag="CAN33_17080"
     CDS             complement(5893..7158)
                     /codon_start=1
                     /db_xref="InterPro:IPR001128"
                     /db_xref="InterPro:IPR002401"
                     /db_xref="InterPro:IPR036396"
                     /db_xref="PFAM:PF00067"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 272.5; E-value: 1.2e-82)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="CAN33_17080"
                     /note="EggNog:ENOG41; GO_function: GO:0020037 - heme
                     binding [Evidence IEA]; GO_function: GO:0016705 -
                     oxidoreductase activity, acting on paired donors, with
                     incorporation or reduction of molecular oxygen [Evidence
                     IEA]; GO_function: GO:0005506 - iron ion binding [Evidence
                     IEA]; GO_process: GO:0055114 - oxidation-reduction process
                     [Evidence IEA]"
                     /product="Cytochrome P450 family protein"
                     /protein_id="ncbi_CAN33_17080-T1"
                     /sec_met_domain="p450 (E-value: 3.8e-51, bitscore: 170.3,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MVTYNLFIHPLKEVPGPRMLAASRIPVTYASLKGIQTQWLHNLHL
                     KYGPVLRVAPNELSFIDPQAWKDIYSSSPTEPQSMRRGSDFFRYLEDDDNRPSILAANE
                     IDHPRIRRAYVPAFSRRALARQESILAKYGDALVERLSGIEGQITNIRNMFHYTLFDIV
                     GHLHFGEELGVLRTGAHKSWVHSQHRLVRAATLLSALAEFSWINLLFRSTIPWMSKWLR
                     KAYFKPSNDLIDRRLQLQSDEPDLIGLAFRNSRSLSLTEKDIRANAHIMMTGGAETTTA
                     LMTALTAYLLQHPECLARLKNDIRTAFHDKSQVSLESVSNLAYLDACIKEALRLYPSVP
                     GALHRATPAGGARIAGRWVSGNTRVYIPIFAATHSPTHFWSPDKFIPDRWLDGADDPYQ
                     KDNKTAFHPFSTGPRVVLVKSK"
     mRNA            8552..9508
                     /locus_tag="CAN33_17085"
                     /product="Trichodiene synthase (TRI5) family protein"
     gene            8552..9508
                     /locus_tag="CAN33_17085"
     CDS             8552..9508
                     /codon_start=1
                     /db_xref="InterPro:IPR008949"
                     /db_xref="InterPro:IPR024652"
                     /db_xref="PFAM:PF06330"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: TRI5"
                     /gene_kind="biosynthetic"
                     /locus_tag="CAN33_17085"
                     /note="EggNog:ENOG41; GO_function: GO:0016838 -
                     carbon-oxygen lyase activity, acting on phosphates
                     [Evidence IEA]"
                     /product="Trichodiene synthase (TRI5) family protein"
                     /protein_id="ncbi_CAN33_17085-T1"
                     /sec_met_domain="TRI5 (E-value: 1.1e-26, bitscore: 89.6,
                     seeds: 3, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MTKAQTAVSPDEFFKIITPFLNEIIPNIPPFAPDEAFYKAVFDKF
                     AAASGLPEDSIPHFVGTGEVLARCFYPSLPRDLQISIGVLTAYVFSIDDQCADPEFREQ
                     IKSYRSVFLGQSTTNLQYIKGLYNTLHDIVSHYEWYAGDMIIKSTMDFVSINIVEAEQT
                     GDFMVSPSTKLFPDFLRQKSGIGEAYAFFYFPGSDWGLGDYFTLIPDIAGIIEQLNDVL
                     SFYKESVLGNEPGTWVKQTCVCKGISEGEAFRERVDQCLGSIRRLRAASEGNPRLLKTV
                     NEFINGYPLFHLNAGRYKLDQFGSYHGWQGEKTAGGN"
     mRNA            17908..18636
                     /locus_tag="CAN33_17090"
                     /product="hypothetical protein"
     gene            17908..18636
                     /locus_tag="CAN33_17090"
     CDS             17908..18636
                     /codon_start=1
                     /locus_tag="CAN33_17090"
                     /product="hypothetical protein"
                     /protein_id="ncbi_CAN33_17090-T1"
                     /transl_table=1
                     /translation="MAPILLSNNIRTPFRYLNRIIHLRKGEDKGKTRAQPDLSSALTRL
                     FANSENDDEESSITHITESTSQIWVEDQDPALVDLLATLSFTITTSTSDSSTLLALLAS
                     ALDILSTYAQNHKVNTLPIYTALLRHLDTYTSYLIWDHEILLTDAEIIFTASSIPTPKH
                     RDNIILQLESAYVSNYETCKTLVTRLNQLVDIELMERADWIFPRQIGWVEVRREVIRLE
                     KTLKEIRWAGKLKEVEYVNC"
ORIGIN
        1 atgcatacga tacccatcac cgtttcttta tacgccttcc tagcgacgac ctttctgttc
       61 tcctgctccg cttatgttgc acaggcaccg ctgagcgatg acaagtgcac cgaaacaacg
      121 gtggccatct tgtaggagct tcccactaat gcttgatatc gtgttggagc ttagcgtcta
      181 acgttaacag gggtggaggg atggccggca ttgcagctgc agtaggtgac cctcaggccc
      241 ctttgcccta aatcccgacc ggcaatgctc accaacacgt ctagcaagcc ttgtccaacg
      301 catctatcga cgactttatc atcctcgaat atcgcgatac cctaggtggc cgtgtctggc
      361 atacggactt cggcaaggat aaacaaggca agccatacgt gattgagcta ggagccaact
      421 gggtatgaca atctacatac atcccgtcaa atgaacatcc gcctcaccat aacaacagct
      481 ccaaggactc ggctccgaag ctatcgagaa tccagtctgg gcactagcca aaaaataccg
      541 tctcaaaaac acctactcta actacagctc catccgaaca tacaacgaaa ccggctacac
      601 cgactaccgc tatttgctcg acgaatacgc gcaagcctac cacattgccg cccgcgatgc
      661 tggccgcatt ctgacccaga acctacaaga ccaaaccgca cgcaccgggc tcgccctcgc
      721 cggctggaga ccacgcaaga atgacatggc ggcacaagcc gtggaatggt ggagctgggg
      781 tatgaacaat taccattaag agggggaaca cccaaccctt tttacaccca tcgggtcaac
      841 accaacccta tcccatagcc caccctcgac taacgcatat cccaaaacta gactgggaag
      901 acgcacatac gcccgaaacc agctccttgg tcttcggcat cgccggtgag aacctaacct
      961 tcaaccaatt cggcaaagcc aaccacctcg tcctcgaccc gcgcggctac agcaccatca
     1021 ttcaaaacga agccctcggt ttcctaccca acccctctga tggccgccta cgcctaaaca
     1081 cccgcgtcac tcgcattgaa tactccccaa ggggcgtaac aatccacacc accaacgaca
     1141 acaacaaaaa cagcaacacc tgcatccgag cggcctacgc aatctgcacc ttctccctgg
     1201 gcgtcctcca aaacaaagcc gtaaccttcg acccaccttt gccctcctgg aaacaaaccg
     1261 ccatcgagaa attcaacatg ggcacctaca ccaagatatt catgcaattc cctgagacct
     1321 tttggcccac agacacgcaa tttttcctat acgcttcccc aacaacaaga ggctactacc
     1381 ctgtcttcca atccctctcc acagagaact tcctccctga atcaaacatc ctcttcgcca
     1441 ccgtggtcga cgaacaagcc taccgcgttg aacgccaatc cttgactcaa acgaaggacc
     1501 agatcctcaa tgttctaaga gagatgttcc ctgataaaca catccctgag cctacggcgt
     1561 ttacttaccc ccgctggacg aatgaaccct gggtctacgg cagctactcc aactggccgg
     1621 cgggaacgac ccttgagatg catcagaatc tgcgggcgaa tacgggccgg ctgtggttcg
     1681 caggcgaagc gaccagtgcg gcgtatttcg ggttcttgca tggtgcgtgg tatgaggggc
     1741 gcgatgcggg tgagaatgtt gccgcgctgt tgcaggggag gtgtgttgag gatgttagta
     1801 ctactagtac tgctagtggg aaagaagaga aggaggaagc gtgtggagag agggtctttt
     1861 atgagcaatt aaatgggact acgccgctgg atgcgtatag tcggttgaac gggtggccgg
     1921 cggtaagtta ctactagaag tggtatggct ttgtagggtc tgctttagtt gttggataga
     1981 ttggatggat gaatggcgtt ggcatgggaa attacttttt tggaatttca tattagtctg
     2041 catcatgtaa cgcaataatt tgggattata catcaactgg cctgctggcc caatggtaag
     2101 gcgcttgact acggatcaag agattgcagg ttcgagtcct gcgtaggtca ttctttttgc
     2161 ttttttctta ggtggagagt ggatctggta cggtggggcg ccttccgtac gggtactatc
     2221 gctggaaatt atctactcgt acagtcgcct ttctctgcgc tcaggttttc tttggggggt
     2281 gtggtatgaa tcggcatctt aagtcggttc ctgtcctttg ttatagcata tgcataattc
     2341 tcatcatagt ctcctagcaa ggtgctaccc aatggagttc aatgtcgtat taatcccctc
     2401 aaactactag tatgctatca atagtatata tttcgggcaa ctactacttc attctaggat
     2461 cagtagtagc taccaaccgt ccagcctgaa cgcccttcac cgtctgaagc aataatgttg
     2521 cccaattcgc tattgcatcc atcgctagtt cgtgtttctg ccaatagcta ccttaaacaa
     2581 cctctgaccg tttcttcgtt gcatcattcg ccatctcatt cataaaagca ctccgtgcac
     2641 gtacctcctt cccccagaca aacattaatg taggtataag cgacaacacc aagcaaataa
     2701 aggcaagtag cgtactagcc cactgatatc ctagcacccg gtacatgctc atcgttgcga
     2761 ggggcaagaa agcagagaag acattctctc ccgcagcaac agcacccatg gcacttcctg
     2821 aaaactgact gtaagagtcg accacatagt ctgatactcc agtcacgaca caaacactgc
     2881 cagcacctac caaggccaag ccaacagtag gtgcaatcca tggaagactc gaatatgaag
     2941 tccaagcata gatgaacata ccgcccgaga gaccgagaac ccctcccacc acagccatgt
     3001 atagcctcgc ctctgggatt ggagttcccg gcacctcggt atttctggaa gcagacgcga
     3061 aatagagctt ccgagaaagg aagttcacta gccagcctag acattctccg atgacgatgg
     3121 cgcattgaac ataaccggtt tgtgaaacgt cccagttata taggcccatg aacacctgct
     3181 caacggactg ggtaaagagg aaaagagtcc ccactgtgaa agcggaccaa agggtcgaca
     3241 cgaagagaac cggctccgta gaaaataaaa tcaccggtct tgtcgcgctg actacaagac
     3301 tatgcaggtt caaacgagag gaaacatccc cgctccctgc ataaccgctg gtctcgtcgc
     3361 cattcttgcg attacgtcgt gctcgtcgtg caagaatcgc gctgccacgc gactcatgaa
     3421 ggaagaagta atagattgga aagagagccc cgaaccaaat gagctgcata tagctaatcc
     3481 acctccagcc taaagagtgg aatatcgcgg cgccaatcac ggggcctgta ctgctgccgc
     3541 tcatgtaacc gagaatatat agactgactg ggatggacct ggaccactca gtgctccata
     3601 gatttccgac aacaccggcg gcggtattgg ccaggatagc gacacagccg ccggcgaaaa
     3661 agcgggtgac cactaatgtt gcgaagttat gagcaacggc ttgaggcacc aggaagcaaa
     3721 taaataatag atatgttgtg aggaagatag gcctcgtccc gaaatcctct gctaggggaa
     3781 gaatgaataa agctgagcat gcaccgccgg tagcccatgt tgttaccggc cagtaagaat
     3841 taggaaatgc atcctcgttg acatggaagt gttctgagat ctcgaagtgc gccacagtaa
     3901 tgatggttcc gttcatcatc gccaggaagg tagtgaaagc agcgaggcat gtcagggtcc
     3961 atttccgtcc cactgaccag ttgtaggggt tttcgggatc attatcgtca tcccaagaga
     4021 gagtcgcggt gtcactttca tttgacgcga tatggtcttg gaagacttcg gtcggggttg
     4081 gagaatattt ctctgtgcag gttgccatgt attcgttgtg cttggttctt actgctcacg
     4141 ataattcacg agtgtatgtc aaatagagat agtaatcatc cgccatatgg ctatggaccc
     4201 tactgtatga cctatatatc attgacagca acatatccag ggctttgtga agcgtcttgc
     4261 ttctcacaat agtgcccttt ttgggaatag ttaattgata gttacttata gtcttggctt
     4321 gatgcagcgg agccctatcg ggaaggctga tggatgcaac tttgcggtaa ctcgcttgac
     4381 ttcgggttcg tgagccgatt agccgccgtg aacacagtgg tatcagtcgg caaccttgaa
     4441 ccgagaaaat gaaaacggtc caacaggccc attgtggaca ttgaatgccc tgcattactt
     4501 ggagttactt tgtagaccta gtatgactgt aaagcgtaat aatgatcata attaccatga
     4561 tgcatgtttt ttgtagctat taattacatc cccaagatcc tagtgatacc ggcgatgaga
     4621 aagaacagct gtactatgcg acgatgaagc cacgaacttg caggtaccgg atcacggtct
     4681 ggtagaatgc caggctacaa tgatcattgt cccgatatgc atcggttatg cttgggaatg
     4741 caacttgcgt gactttcctt actaagaatg tgccgaaaag cgactattag cagctgacga
     4801 agatccgact gaagtccagt tcacgagcca atggttcaca cggcgtttta agactagtat
     4861 attgggctaa tcagtctaga acaccatctt acaagtagga atatcggagt gcgtgcaaat
     4921 gcgcgcccgc taatctatga caagaatgag aatctgagcc tcagcagact gagttactgc
     4981 taactcaatt aggtgaacga tcggagaacc agaagaactc tacggatttc gcccgcattg
     5041 ggcttgatga tcttcactgc atatctgcca agtcaatcat tcttcccgag cagcccatgc
     5101 cttcacttcc taatcgagaa cccgacgcct ggaagatccc gagggtatct cggaaaggca
     5161 cccgaaggca tatgtacatt gtaacttagg ccatacccgc ggacaggctg aatccagacc
     5221 acaaaataag ttaaactaac ttcggtttgg cgcatccgcg catcccagag atacagtgaa
     5281 gccgaagacc aactgacagt tgggccgtgg accacgggca accagccacc gcgggactgt
     5341 aattataggc cacggtgttg gacccagaaa taccgttacg gtctttacgg atatcatatt
     5401 caagccggcc cggattcgaa tgagctagtt aatgtattat tcatttcttc ttttccattg
     5461 ataacattct ttccctttct cttgagatgt gctgagtacg aagctgatat gagatgcatc
     5521 tagggcacct gtggccacaa cgagaaggat agtcaagtac aaagatgaca cgacaaactg
     5581 accatactca aggttatcac tacatcgtca ttctttccat gtcccatgtt tcacgaacgt
     5641 catatcccaa tattatatcc caatcagctg ctaacctttt ctgctggctt gcacctggat
     5701 acacgcacca tgagtggtgg cacttcccat gttgtccatg aacgatgacc tgcgagccag
     5761 gggctagatt cattaactgc aagttcacag tcaaactccg ttacaaattt gcagaatact
     5821 atttttgtca tggcatatgc catgctattt tacatatcag ttagacaatt tcatgcataa
     5881 taggtattag gttcacttac tcttgaccaa tacaacccgc ggacctgtgg aaaatggatg
     5941 aaatgccgtt ttattatctt tctggtacgg gtcatctgca ccatctagcc agcgatcagg
     6001 aataaatttg tcagggctcc agaagtgggt gggggaatgt gtggctgcaa aaattggaat
     6061 atagacccgc gtgtttcctg agacccatcg accggctatg cgcgccccgc ctgcaggggt
     6121 agcacggtgt aaagctccag ggaccgaggg atacagcctt aaagcctcct tgatacaggc
     6181 atccaagtac gcgagattcg acacagattc cagagatacc tggctcttat cgtgaaatgc
     6241 tgtgcgaatg tcatttttga gacgcgcaag acactcaggg tgctgaagga gatatgcagt
     6301 taaggctgtc atgagcgctg tggtcgtttc tgctcctcca gtcatcataa tgtgggcgtt
     6361 ggcacggatg tctttttcag tcaacgacaa gctgcgactg ttgcgaaatg caaggccgat
     6421 aaggtctggt tcgtcgcttt gcaattgaag ccgacggtct atgaggtcat tcgaaggctt
     6481 gaagtaagcc ttgcggagcc atttcgacat ccagggtatg gtcgaccgga ataaaaggtt
     6541 aatccaggag aattcagcga gagctgataa taaagtcgcg gcacgtacca gcctgtgctg
     6601 gctgtgtacc cacgatttat gtgctcctgt tcgcaagacg cccaattcct cgccaaagtg
     6661 caaatgccca acgatgtcaa aaagcgtgta atggaacatg ttgcgtatat ttgtgatttg
     6721 cccttctatt ccagaaagcc tttcaacgag agcgtcgcca tacttggcaa ggattgattc
     6781 ctggcgggct aaggctcgcc gtgaaaatgc cggtacgtat gctcgacgga ttcttgggtg
     6841 gtctatttca ttggccgcaa gaatagaggg ccgattgtca tcatcctcaa gatatctgaa
     6901 aaagtccgac cctctccgca tactctgtgg ctcagtggga gaactgctat atatgtcttt
     6961 ccaggcttgt gggtcgataa agctcagctc attcggagca acacgtagga ctggtccata
     7021 tttgagatga aggttatgga gccactgtgt ttgaatcccc ttgagtgagg cataagtcac
     7081 gggaatcctg ctggcggcca gcattcgcgg gccggggacc tctttcagtg gatgaatgaa
     7141 cagattataa gtaaccattg ataggtacta tagatcactc tcggtcttag ttctctcaat
     7201 cactgaagta tcttctgaag aatagcagcc tttcataact gaccagaaaa atccctgttg
     7261 ccacaagaat gcttgccacg ttttcttccg gcatcttggc tccgaagata tgtcgtgcaa
     7321 ggccatttaa atgtcgacgg ggagtgttat atcaaataga ggaagtgaga gaacaatgca
     7381 gagtggtaga ttgacttgct cgtagaaaag ttatctccac caactatttt cagagtcgaa
     7441 taactgcatc tacacgaggc atgggaagtc atcaaaagtc gatctacaag tggtaagttt
     7501 ttcaaacagg acgatccagg gtgtgagtag gatgttcctg tgaccttgtg taaccgacct
     7561 cattattcca taaacccctt acatcaacca ccgctggaac cataagaggc atacatgatt
     7621 attccatagc caagggctat atattagcag aagaaatcac tgtctgctgg gtgagcaata
     7681 ataatggttc ctctatctca tgtcaaagca gccgcctcgc tatagccaaa aattcaaatc
     7741 actcatatcg gttagtatct tgaagaaaac cttgacagaa gcaatgcaca gagatggatt
     7801 atcatagtgc ccaaatagga cggatgcaga gctgtcacac aatgttctat acctccttga
     7861 agcgagcacc tggatttccc ttgctaactc ggacagcacg acacttgcta ttagtccccc
     7921 ggtcattttc accgtcaaaa gatcaatacc ctattgatgg tcttgtacgc taattagggt
     7981 gtagtagcag accggttgag atacaaagca cacccatcca gagatcagcc tatactcttg
     8041 caagcttaca acattcctcg acccacaagc acatcatacg tcgaggatgc atatctgcaa
     8101 atccccacgg ctgaacactt gctgatctct ttcattctga gtagcttgtg cataagccat
     8161 taacttgcac ttaccgcgca aacatcatct catttgtcta taccattatt catccatgtc
     8221 atctcacaca acatgaccat ccttgcatgc agatgtctca tggcaaactc acccatactt
     8281 tttcgtcagt gtgacaaagc tgtgcaaatg cctcttgctc caatgtcaac gccagtcata
     8341 tcaacgatat gacgacattg actttcttat caaagccaca gacaccatta ttgtccttga
     8401 gaatgtgcga tgaatccgat atggcaacct aatgacgtag tgaaatgttt tttttgacga
     8461 acagctccaa ctacactcat ccgctttaat agtaccttcc caatacctag tacatcccac
     8521 aacaccataa ccattagcac ggtctgcaac aatgacaaaa gcgcaaaccg cagtatcacc
     8581 cgacgaattc ttcaaaatca tcaccccctt cctaaacgaa atcattccca acatcccgcc
     8641 cttcgcgccc gacgaagcat tctacaaagc agtcttcgac aaattcgcag ctgcctccgg
     8701 cctcccagaa gacagcatcc cccacttcgt cggaacaggc gaagtcctag cacgatgctt
     8761 ctaccccagc ctaccccgag atctacaaat atccatagga gtcttaacag catacgtctt
     8821 ctcaatcgac gatcaatgcg cagaccccga gttccgcgag cagatcaaat cgtaccgctc
     8881 agtctttctc ggccaatcta ccacgaacct ccagtatatc aagggtctat acaataccct
     8941 tcacgatata gtcagtcact atgagtggta tgctggtgac atgatcatca aatcaaccat
     9001 ggacttcgtg agtatcaata ttgtggaggc ggagcagact ggtgatttca tggtctctcc
     9061 atctaccaag ttgtttccgg acttcttgcg acagaaaagt ggtatcggtg aggcttatgc
     9121 gtttttttat ttccctggga gtgattgggg tctgggggat tattttacgt tgatccccga
     9181 tatagcgggt attattgagc agttgaatga tgtgctgtcg ttttataagg agtctgttct
     9241 aggaaatgag cccggaacgt gggttaagca gacttgtgtc tgtaagggga tttctgaagg
     9301 tgaggctttc agggagagag tggatcagtg cttaggcagt attcggagac tgcgtgctgc
     9361 atctgaggga aatccgagac tgctaaagac agtcaatgag ttcattaatg ggtatcctct
     9421 cttccatctt aacgcgggta ggtataagct ggatcagttt ggcagttatc atggttggca
     9481 gggtgagaag acggcgggtg ggaattgata gtataacagg ccaacgcagc tggaagggat
     9541 tggaataaga ttgaactcgg gtcaaagcat ttaagactaa gaatatactg gtgtcaacaa
     9601 cgtgaagagg gacgttcatt gcaatttggg ggccatcacg attctatata ctaaggcgga
     9661 gcgagagtga cagggccgcg ttgctcaaac tttcacagca caatactagg atacctttca
     9721 caagactcaa agagaggaca gtccattgat ttcattactg atcacgaggt gtacgcaagt
     9781 gtcacacttc ctccaaaaag tattcgctta tttccaagcc gagtcctaaa ttaggtggga
     9841 aaaaggaccc tatgatctgc cctgtgcttg gatcataagg aaggctctca tcgtaagtat
     9901 cctgagcggt ggtatccttg tccgtatgca tgaggtcggg actttctgaa gcaggctggc
     9961 cttttaaatg ggcttccaga gaagttgacg gatctgagag cggtagagga ccacatccaa
    10021 gttcattagt ctgcggctct ggagcagacg aaagtccggt tggtccaggt ccaggcgtaa
    10081 cagaagtgcc gaatctgcta gggatgggcg ggttgggtaa attcacgccc gcatattgtt
    10141 cgatacggcg caaaagacct tcgcatagta agcgagcttt ctccgaggcc gcgttggtat
    10201 ttgcgagtat agcaagccat ttaagtgctc tttcggtcgc cttagaaacc atcgatgctt
    10261 tctctggtac gtggcaaaca ccaaaagaca gttccattaa aaggaccgtg gttgcttgta
    10321 caagaaaatg cagtatacac caccaaggtg acattctgta cagcgcagca gcatctagcc
    10381 catctgggaa caatctcagc atatggcaag ctgattccac gcactcagct gctgttctct
    10441 gacagaaatc ctgtatcttt tcatctggag ttttgccatc ctgattcaca ggattgggac
    10501 ggcgcagaca tggccgtgtt attccaattt tggtgctata gaatataaat gccaggctca
    10561 ttcggtggtt agatatcgaa tgagtaacct gcgtggattg ggtcgaggta aagtcaaact
    10621 cattaggaag gctcagaagc catgattcga tgtcagatgt aagaccttgt atggcgaatt
    10681 ctatccccat ccaagacgtg ctcgctgctg agggactgta aagcttagtt atcatcttct
    10741 ttgatatcag catgagccga atgacatgga agaagtgcaa cgatccagag ggaggaccgg
    10801 aaattgcgcc tgtacccttg gagattgcta ttgagtgttt gcccatcaaa tcaaaatctg
    10861 tatgaattcc ttcagttccg tgtgagaacc ggaggcaatt tataacttca tccttcccga
    10921 aatccttttc gtcaaatggt actggcagag gtgttgtata gacagtatca tctatgaagg
    10981 aaggccgtcc cgtgattatg ctaagtcggt gatcaagcgt gtagagagac caccatacac
    11041 gatatcgaat ctccctggaa gtatccgaag cagacttgct catgttgcgc agatgcaacc
    11101 caagaccaag ggctccccga acagcacttc cacagattct ccaggcactt ggtatattcg
    11161 taagcactca catgaatagc cgattcgtac ctcccgacat gatatacgta ccggttgaca
    11221 tgccccaatg aaagcatgta taaagctgtt agcccttcca cttgtaattg ctgtaggtca
    11281 ggatgatgaa agctccaatc atctatactc aagaccctcg ctcttgagaa atacaaccag
    11341 tgattattct tgttcagctg ccattctgct tcagagatgt aagcatacct agcagcaatc
    11401 gcaaataata ggttcaagac tgcgagccac ttgttacccg tatgtaacct ggtatcgttg
    11461 aagaatgcgt ggaactgttt tccaaaaggt gtggttccta tgattgggaa ggtaggatgc
    11521 acccaatcca aatagcagtt gtagagcttt gaagctacat cctttgatgg tagtgcatat
    11581 gcctcttgtc gctcgatatt tggcagttct tgatcatcaa catggtaatt cgatgcggag
    11641 ataggactac tatcagagat cgataaaaat atagcttcgc tcggagtacc gtgctcagtg
    11701 tctccattga tatctcggcc taatgagtgt atccatgata tttcggagct ttgaccaata
    11761 taaccagtag cttgggaaat ttcgtccttg ttgaagtctt cattgatgca atcaaggcag
    11821 tggcttgagt caacatatag tgacaactgg gaactggtag ctgagagagg tctttgagtt
    11881 ccgggcaagg gggttcgccc atcgggggac aaggaaggac tagaggactc ttcctacttc
    11941 cggtcagtat aaacactcga agagagagga cgaagaggat ataacgggct caagaggatc
    12001 aaaggatatg gtttcaacga gagcaaggcg aggggcctgt attcatacca cagtcaatgc
    12061 aaggttcatc agctgctcat tcgtaatccc aaatctgctg ctcaggttct tcaaagcatc
    12121 ttcgtaagtc cgtattttgg cctccaagct agccaattgc cttggcgtac caatttctct
    12181 gaagtcagcc acggagccat ctaatcagat tcagactcac ctcttggatt tctccctttt
    12241 accatctgta tagcagcaaa tgatgccagc ctcacggcag ttgcgacaac cggacttatc
    12301 tccagtgcac tttgtctttc tctgtctgca ggattcacat gctcggctca cgtggcgacg
    12361 atgaaatcta cctggagttg agaatgtttc cagcccttct gctagcctag gaattgccat
    12421 cttcttgcta gtcaaaggat gctccgctct gtgggaggac aatgcatgag atgcactacc
    12481 cttgagatcc tcagttaact ttcggactgg tagatagacg agagggggat cggatggccc
    12541 tcaccacatc gctgtagttg tgcgaaccgg tcgaggatat cctgaaggtc ggttgttctg
    12601 gccaagatgg atactgcatt gtgctatgaa ggtctaagga agaaagtcca caattctgtc
    12661 caagcaatca ttagtagctg ttctgtagca gcgccttaga gagctcatct tgatgtcacc
    12721 catcactgat accttagaga gttgaacaat tgcaggatga tacaccagag taattgagag
    12781 gatgtcgata acgtttacag aaaaggtagc tgagctgaat cttaatatat aattttaaga
    12841 ctgagttctt caacgaaagt atagggatgt aactcagccc gaaagagagt gaaactagct
    12901 ttgaaagagt aacgtctcac ggttcatcaa aaatcgaacc ctcgatcagt ttcttccccc
    12961 caacaagatt tcttttggtg aaaagtgcag gcggaaagcg cagtcgtggc tacttccctt
    13021 gtgtctcttg tttccctcca gccgaggatc ggcccgtctc tgagtctaga tgctaggtac
    13081 caaattatca accagaaaag cgagaactct aggagaccag gtattaggga gaccagaatt
    13141 gccgctgatt tccatggata tgaaatggta gagtgctacc agctccggaa aatgcaggga
    13201 atgtagacgg attattcacc atgattagcc agccgctcac tgagtaccgt ttgcttcaag
    13261 cgtaaccgca acattttctt tgactggcta gacggcagtg ttatgagaga gggttgaggg
    13321 cttgacacaa ggttaaatct ggaccagttc atcgttgtat ttaggcagga tatggagtac
    13381 gtgatgggcc cacgaggata cttccatcat cttcgttggg gccaagctaa acaatgtgct
    13441 catagtgatt agctcctttg ggcgaaccac ggtcgacatc agcagagtct gtactgcatg
    13501 taacgttctc agagtttctc cgtcatgtgc ctgccagcct agcggaaatc ctggataatg
    13561 gcccagagga ttaaactttg ccctgcgcaa ctaatacgca tacagaataa attttccact
    13621 ccatgaagaa tatttaggtg cctattcgga cccgaccagc cgaatatatc cctgtatccg
    13681 ggtcaccctc ttcgtagtcg gttatttgca gcggcttaag gtgatagttt actgatccaa
    13741 gaacattcgc gtgtacacca tcaaaatatc tgttatttct agaaaaaact gacactacca
    13801 ttcgaaaaca gattgatgat aagtgagtca aaattcaata aataaaaaaa aacacaaagc
    13861 tttgttatca tgaatcgtac atataatgtg gcccgatggc tttgttttaa catgcgtagt
    13921 ggatgataac tattactcga gcagatgaat tatagttcaa agtacgtatt gagtgaaaca
    13981 tagattcttt tcaaattaac agacaataga tgaaatgatc tttagaattc cttacaattg
    14041 tccactggat ggacgagact ggagttgcag aatgcggtag cgggccagga caacagacac
    14101 tgccataagc ccctcccagg cagatatatt gagtatcgtg ttagtcatag tctaatgtat
    14161 tcaggacgaa ggtgcaccat ctgtgatact gtgacaagcg atttcaccat agcatcctga
    14221 tcgattcacg gagtagcctg atagtccatc tccgtagcct ttcagccata aggaaatttc
    14281 atcggctgtg tgcaaacttg agcaggagat ttatagggat aatatggtcc tacgttacac
    14341 tcctaactta aaatcgaatc actcattagt tgatcggtac cctccacatt taccttgtca
    14401 attgccacag tatcatgcca ctttccgtgt cgaatatgtt acctaaagcc ttaggcctga
    14461 tccacggtac aagggctgga ctagaggctc atgttctgca gcctgattac acataacgag
    14521 aataatgaaa taagtttgta gttttattat ctccagattg gacccccacc attttactct
    14581 taaccaatgc atcggtgata tccaccgaac agaattacat ctgaagtgat actgatgaag
    14641 aaagctggcc cagacaggcg ttgattgctt tggccaggtt gtggtttcgt gaagcaggaa
    14701 ttagtggtgg tggtggagga catagagcag gcgttgtcct gtataccaat ttcgcaaacc
    14761 ggtgcaaatt ctcaggaatc ggtcatattg gactgtgggg aatatgaatg actttgactg
    14821 ctgtaataga cgccttgagg ctcgatgagg cagtctggtt gctggaagtg atataaacag
    14881 agaataaggc tacagtgaag aaccatgcag ccttggcttt gcccgttaaa ttatcttgag
    14941 tcacagaact cgcacatttt ctttcacggc acgtcccgct ttcacgctgc ttggttgtgt
    15001 gtgctacaat aggtatataa atccctgctt ccctcgcttt tctctgtcta tccaatcttc
    15061 cttctcatca catctgaagt tctgcagcct cttagtcacc gaaacgcatg ttacgtattt
    15121 gatccctaca gtccgatagg ttataataaa gcgacctata tacccgttga tgtctctacc
    15181 acattgtgta caatggaaag tggtgtaccc ccaaagcttc atgactctca cgacacatcg
    15241 aaatgctcta cgtatcactt tggatatgag actataactg acccatgctg aacatatacg
    15301 gcagatcctc ctctggcccg aagaatggga ttccatgacg ctatgcctcg tacgaagaga
    15361 gccatcggcg catccaccgc aagctgaagg acagatgaac tagaaacctt aagagcatac
    15421 ataagagatt ctcctcaggc tcagcgatat caatgagttc tgagctttgg aatgattgag
    15481 tcacttcttg gggttgcgtt cggcacgtat atataatcgg aactggatta taggtagtac
    15541 ctaattcacg acgtcatgga aattcacgcg gctgttcttc agttgaggat gactggctgt
    15601 tgcatatgag cgtgggtaaa ggagcattct ccacctcgct gaagacagct ttagaactcg
    15661 cgaagctcct atgcgcaatc atgaccactt gggcattcga gatttttaag tgttgccctc
    15721 atctcagtgt tggcagacta agctacggtc cgctgctctt gaggacgcag gagcatcttg
    15781 tgcgctgcga atctgtactt tccatcggga tcccttccgg gggtgtcatg gtagtttaat
    15841 gcgacagagc ttgccagaca accgaaatcc atgaatgcag tctcaatatg cacacttcaa
    15901 catttcacgc tcgcacaaat gcttttacga gccatggctg ctacaagtat tgaaagatac
    15961 atcaaaaagg aaaagcacaa cgacttcctc acaattcaga gattgaggat tttcgtgtac
    16021 ccagcacgga gcaagcatgc cataccggct gatcactccc atgcccacga cagctatgga
    16081 ctgcacgcca gtctgagtac tgctggtgtc ttcgccgata gaaaagacaa ataaacagcg
    16141 aatcgcaagg caacgaagga tatgtctcac gggttctctg agaaatgata gtctcatcac
    16201 gcaattacgt ctccaccagt cccgaagccc aggtccaccg gcgcctgcgg atggaagtag
    16261 catacaaaca tctctagacc ttttcattat catgaatcga ttcttaatat tgtactgtga
    16321 aagctgcatg gttagctcat ttcaacagtg cagtctctat caggttgtat agtgtgaact
    16381 gggctgatgg gattgaagaa catgaataaa ttctgaactt gggcgagcta tcggctcatt
    16441 cccatttgtt tagctttgcg ttattgtata tgttttcttt ggcgggttta agcttattaa
    16501 cgatattctt ctccttccga tggtgaagga cctgatggct aacacctgtg taacagaaat
    16561 aatgagctgg aagactacga atttcattgg gtaagttttg gagcttttct tcatctcgaa
    16621 gattgcctct ctattaacaa cttgtagcaa ccggaaatgg cactgtgata tggcctcctt
    16681 ccctacggag atatgcgtat gttcaatacc gaaggttgct tcaccgacgc aatgatatca
    16741 gactagcctt cgacatagga ggatgactgc tatgggcatt caatgtcgat ttcctactgc
    16801 tgttagtcta tctccaagcg tagcttttgc tatgacaaaa ctggactagt atacagttaa
    16861 aggttgactt ctgtgtcttc tatacctgtc attgacagac ccattcagct atccggcaca
    16921 actagaagga gcgtaaaagc caagtaaaac gatatttagg aaatgggcga gtacgtccta
    16981 gtaatttagg ggaataaaat ccagaaacat ccacatcggg cattacatag aaactgcagg
    17041 gtgtgattca acgcgatgta accacaagca tgcaggctgc atcaatattg tgatctgcgg
    17101 gatagagatc ttccgatatc aatgaaaggt ccgacagagc gtcgtgaaga ccttcgtact
    17161 gctattggag attatggatc ctgacctctt cgacggagta ggcaaaggta atataggatt
    17221 ccatccaaga agagcacaac aggagccgtc ttggaatgcc aagccagtcg caagatttaa
    17281 tggctatggc atgtcaacgc cattagccat ccccttccat agaataaaac cgcgaaagat
    17341 gcaatcttca ttctggtagc ttccggcaac ataaagacga agcgagcgat ctcaggagaa
    17401 gcattccagc tttgtacatt tgctgttgcc aaattttgtg gcctaattaa ccaaatgact
    17461 tctatttctg ctggtgacga taccactacg ctgcttcctg gcaggaaccg aagtgaccag
    17521 tatagcctgc gaagtcaata tgtcatcaat ttctatatta agcctatgtg aatcaaagtg
    17581 acccatggat gggaagaaaa atccgagttc aagaactata tcgtctattc ttagtttcta
    17641 atgttctgat tgctgagtat ctcttctaca accctcaaca ttatattcaa gttttatcat
    17701 ttgaacactc ctaccctatt atctaccagt ttactagcaa gcttcctacc tttggaaact
    17761 ccgctggaga ccataccatc gctaccaaaa ttccgcccga aacatctcag acaccgactt
    17821 ccctcaaaag ctcctctgca taggcgactc tattcaccct ctgccctgtc aaccaaatct
    17881 tcagtaccca tcttaaccat ctataagatg gctcctatcc tcctctccaa caatatccgt
    17941 actcccttca gatacttgaa tcgcatcatc caccttcgca agggcgagga caagggcaaa
    18001 accagagccc agcccgatct atcatcagcc ctaacccgac tcttcgccaa ctctgagaat
    18061 gacgatgagg aatcgtctat cacccacatc acggagtcta cttcccagat atgggtcgaa
    18121 gaccaagatc cagccctcgt tgacttactc gccacactct cctttaccat aacgaccagc
    18181 acatccgaca gctctacgct tcttgcactt cttgcttctg ccctcgacat cctatccacc
    18241 tacgctcaaa atcacaaagt caatactctt ccaatctata ccgccctctt gcgtcatcta
    18301 gacacctata ccagctatct catctgggat catgagatcc ttcttacaga tgcagaaatt
    18361 atctttaccg cctccagtat tccaacccct aaacaccggg acaacatcat cctccagctg
    18421 gaatccgcat atgtctcgaa ctacgagacg tgcaagacgc tagtaactcg tcttaatcaa
    18481 ctagttgata tagagctgat ggaacgtgcg gattggatat ttcctcgcca aattggctgg
    18541 gtagaagtaa ggagagaagt tataaggctt gaaaagactc tgaaagaaat cagatgggct
    18601 ggcaagttga aagaagttga atacgtcaat tgctaa
//
