LOCUS       NKJJ01000011.1         15728 bp    DNA     linear   PLN 19-AUG-2019
DEFINITION  Aspergillus niger.
ACCESSION   NKJJ01000011
VERSION     NKJJ01000011.1
KEYWORDS    .
SOURCE      Aspergillus niger
  ORGANISM  Aspergillus niger
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Eurotiomycetes; Eurotiomycetidae; Eurotiales; Aspergillaceae;
            Aspergillus.
COMMENT     'Annotated using funannotate v1.6.0-df4262f'.
            ##antiSMASH-Data-START##
            Version      :: 5.0.0
            Run date     :: 2020-11-02 06:54:43
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 1485610
            Orig. end    :: 1501338
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15728
                     /aStool="rule-based-clusters"
                     /contig_edge="False"
                     /core_location="join{[1490477:1491148](+),
                     [1491208:1492654](+), [1492703:1492794](+)}"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      join(4868..5538,5599..7044,7094..7184)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     cand_cluster    1..15728
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..15728
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="9"
                     /rules="(Terpene_synth or Terpene_synth_C or phytoene_synt
                     or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps
                     or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /tool="antismash"
     mRNA            join(1..40,99..819,899..1019)
                     /locus_tag="CAN33_18585"
                     /product="Protein phosphatase inhibitor 2 (IPP-2) family
                     protein"
     gene            1..1019
                     /locus_tag="CAN33_18585"
     CDS             join(1..40,99..819,899..1019)
                     /codon_start=1
                     /db_xref="InterPro:IPR007062"
                     /db_xref="PFAM:PF04979"
                     /locus_tag="CAN33_18585"
                     /note="GO_function: GO:0004864 - protein phosphatase
                     inhibitor activity [Evidence IEA]; GO_process: GO:0043666 -
                     regulation of phosphoprotein phosphatase activity [Evidence
                     IEA]; GO_process: GO:0009966 - regulation of signal
                     transduction [Evidence IEA]"
                     /product="Protein phosphatase inhibitor 2 (IPP-2) family
                     protein"
                     /protein_id="ncbi_CAN33_18585-T1"
                     /transl_table=1
                     /translation="MSHHMEDAHKRPKGILKNSSSQVPQVAQHAHATLTIPSTSADPTD
                     TKELTLQNTLQNAGRRRSSSNTRPGSSSRRQSLASIHGHHDDSSPRLKWDEANLYLTEQ
                     EKTAKMKIDEPKTPYAPRYDPAEDEDELAGEESLIDAQDIVVDELDKTKKAPKKTVAED
                     DIPELELGEAEEYGGDAHMGDADRIVRERSLSNDSHRGGKHVVVGAGELNGETESGGDT
                     LMTAGEAEEKHRQFEQHRKKHYEMRNIKDLLAHPEDLEDEMDEDEDEGDSSSAAVPPPM
                     PRIPERFLNGGK"
     mRNA            join(2738..3501,3601..4234)
                     /gene="SFH5"
                     /locus_tag="CAN33_18590"
                     /product="Non-classical phosphatidylinositol transfer
                     protein (PITP)"
     gene            2738..4234
                     /gene="SFH5"
                     /locus_tag="CAN33_18590"
     CDS             join(2738..3501,3601..4234)
                     /codon_start=1
                     /db_xref="InterPro:IPR001251"
                     /db_xref="InterPro:IPR011074"
                     /db_xref="InterPro:IPR036273"
                     /db_xref="InterPro:IPR036865"
                     /db_xref="PFAM:PF00650"
                     /db_xref="PFAM:PF03765"
                     /gene="SFH5"
                     /locus_tag="CAN33_18590"
                     /product="Non-classical phosphatidylinositol transfer
                     protein (PITP)"
                     /protein_id="ncbi_CAN33_18590-T1"
                     /transl_table=1
                     /translation="MADQPEKTAAAPAAPEAQPPTTATTTTEPAVSESQTQPEPQPEAE
                     QKVEQATTGEEASPAPAATEPPVTEPTPAPAQEAPEDKKEEAPKEETKETKAEESKEEQ
                     KAEEPAAEPKAEAAKEEEQKPAQPEYLAKNPALSQFFDRLSAILSSTGHNEMWGVTLKD
                     SSDVPTVNILIKFLRANEGNVKLAEEQLTKALQWRKEMNPLALTEGRYSAERYGGLGYV
                     TKYPEANGKETIVTWNVYGNVKSIDQTFGDVDGFIKWRVALMELAVKDLKLSEATTVID
                     YDGEDPYQMLQVHDYQNVSFLRLNPTIKAASKKTIEVFSMAYPELLREKFFVNVPAIMG
                     WMFAAMKVFLSKNTTRKFHPISNGANLAREFPSLKDKFPKTYGGNGATLEEDAFTVNLE
                     KAEPAPEAPKEEPKEESKQEQAEAPKEEVKEEAKEEAKTEQPAAEEPAKAEAAVTTQEA
                     PAAAEAK"
     mRNA            join(4868..5538,5599..7044,7094..7184)
                     /locus_tag="CAN33_18595"
                     /product="squalene/oxidosqualene cyclases family protein"
     gene            4868..7184
                     /locus_tag="CAN33_18595"
     CDS             join(4868..5538,5599..7044,7094..7184)
                     /codon_start=1
                     /db_xref="InterPro:IPR002365"
                     /db_xref="InterPro:IPR008930"
                     /db_xref="InterPro:IPR018333"
                     /db_xref="InterPro:IPR032696"
                     /db_xref="InterPro:IPR032697"
                     /db_xref="PFAM:PF00432"
                     /db_xref="PFAM:PF13243"
                     /db_xref="PFAM:PF13249"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: terpene_cyclase"
                     /gene_kind="biosynthetic"
                     /locus_tag="CAN33_18595"
                     /note="BUSCO:EOG09260SIZ; GO_component: GO:0005811 - lipid
                     droplet [Evidence IEA]; GO_function: GO:0000250 -
                     lanosterol synthase activity [Evidence IEA]; GO_function:
                     GO:0016866 - intramolecular transferase activity [Evidence
                     IEA]; GO_function: GO:0042300 - beta-amyrin synthase
                     activity [Evidence IEA]; GO_process: GO:0016104 -
                     triterpenoid biosynthetic process [Evidence IEA]"
                     /product="squalene/oxidosqualene cyclases family protein"
                     /protein_id="ncbi_CAN33_18595-T1"
                     /sec_met_domain="terpene_cyclase (E-value: 3e-15, bitscore:
                     52.5, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MSGSHIGPWRTPAQGHLTPDANGDLKTDYTRWRLRDDRGRQTWHY
                     LESDAENEQWPQSIADKYFLGLPTGLPELPKPQTPLQCAENGLEFFSKLQLEPGNWACE
                     YGGPMFLLPVLIITYYVTKTPIPPEYATEIKRYLFARQHPEDGGWGLHIEAHSSVFGTC
                     MNYVTLRLIGVSEDDPRMIKARGLLHQFGGAIYGPHWAKFSLAVLGVMDWECVNPVPPE
                     IWLLPDWVPFAPWRWWIHIRQVFLPMSYLWSKRFSHPLDPLTKQLRQELYTQPYDSIDF
                     AAHRNSIHKADNYYPKTWLLNTLNSLLVNIWNPYLRVPAIVRRAEEWTWELVRMEDENT
                     DYAGLGPVSNPFNMIVCYEHDGPDSYSVRRHRERLHDYMWMKDEGMLMNGTNGVQVWDT
                     AFITQSIVVAGFGDDPKWRPMLTKALEFLEDHQLRENVPDQEKCYRQHRKGAWPFSNKT
                     QGYTVSDCTAEGLRSTIQLQEMHNFPKLISEERLKDSVDCLLLMQNPTGGFTEYETTRA
                     SEKVEWLNAAEVFGGIMIGYDYPECTTASVTALSLFSKYYPNYRAAEIKSAKEKAVQYI
                     KRVQRADGSWYGSWGICFTYAAMFALESLASIGETYETSADSRRGCEFLISKQKEDGGW
                     GESYLSSEKHVYVQHEKSQVVQTAWASLALMEAGYPHKEPLRKAMQLLMSRQQANGEWL
                     QESIEGVFNQSCMISYPNYKLYWPIRALGLYARKFGNEELV"
     mRNA            join(7597..7962,8292..8393,8449..8628,8681..8752)
                     /locus_tag="CAN33_18600"
                     /product="CS domain family protein"
     gene            7597..8752
                     /locus_tag="CAN33_18600"
     CDS             join(7597..7962,8292..8393,8449..8628,8681..8752)
                     /codon_start=1
                     /db_xref="InterPro:IPR007052"
                     /db_xref="InterPro:IPR008978"
                     /db_xref="InterPro:IPR011990"
                     /db_xref="PFAM:PF04969"
                     /locus_tag="CAN33_18600"
                     /note="GO_function: GO:0005515 - protein binding [Evidence
                     IEA]"
                     /product="CS domain family protein"
                     /protein_id="ncbi_CAN33_18600-T1"
                     /transl_table=1
                     /translation="MNAASLGDTALQQSDPHTATIHYTTALLTHPRSPSYFIKRSTAFS
                     RLKPTPNLSAALRDAESAVLLARERGKRELIVEAQMRRAIVLFLMGRYVAAEGVVGVVE
                     GMIGLDKDGNGGEDKEEKVRHEWYQSGETVVVTLYVKGVPKDKVAIELKEDSTSIQFPL
                     PSGAEYDFTLDPLFAPIDPSTSKVSVFSTKIEISLRKKTPGQKWSALESTTGPPKPHHT
                     PPPPATAPKTGTSSPPA"
     mRNA            complement(join(9613..10714,10772..10827))
                     /locus_tag="CAN33_18605"
                     /product="PQ loop repeat family protein"
     gene            complement(9613..10827)
                     /locus_tag="CAN33_18605"
     CDS             complement(join(9613..10714,10772..10827))
                     /codon_start=1
                     /db_xref="InterPro:IPR006603"
                     /db_xref="PFAM:PF04193"
                     /locus_tag="CAN33_18605"
                     /note="EggNog:ENOG41"
                     /product="PQ loop repeat family protein"
                     /protein_id="ncbi_CAN33_18605-T1"
                     /transl_table=1
                     /translation="MFPAVTGNIDLEALSGICGSISIACWVVVFSPQIIENFRRGSADG
                     LSLLFLIVWLAGDVFNILGAVLQGVLPTMIILAVYYTLADVVLLAQCFYYRGFTLRDEP
                     SSPPRPVSPITAETYDEDTEIPSPVVPRKPTERTALLTSKQRSASYQAPLDTRSPASSA
                     TITPHHQPLLAHRRHSASSFLHTTVDGTHLSPVTPLVEPAKQPRPPRTLTLLQATFFNG
                     SAIILVCAAGILGWYISQTSSLSSDKNNNNKHKDSPDDLKMDTLGQVFGYLCAVLYLGS
                     RLPQILLNYRRKSTDGVSLLFFLFACIGNLTYVLSILAYSPVCGRSHHGRCRSDELASL
                     YGRYILVNLSWLIGSFGTLLLDMCIFIQFFLYQDANGGEVDAEAR"
     mRNA            11331..12485
                     /locus_tag="CAN33_18610"
                     /product="Sir2 family protein"
     gene            11331..12485
                     /locus_tag="CAN33_18610"
     CDS             11331..12485
                     /codon_start=1
                     /db_xref="InterPro:IPR003000"
                     /db_xref="InterPro:IPR026590"
                     /db_xref="InterPro:IPR029035"
                     /db_xref="PFAM:PF02146"
                     /locus_tag="CAN33_18610"
                     /note="EggNog:ENOG41; GO_function: GO:0070403 - NAD+
                     binding [Evidence IEA]"
                     /product="Sir2 family protein"
                     /protein_id="ncbi_CAN33_18610-T1"
                     /transl_table=1
                     /translation="MTAPAIRIPFTGPLPPPIIVPPSARTVAGAIDALLAFLTAPPSPY
                     LRGVDVGRHSQTVLLTGAGISVASGLSDYRGENGTYITNKTYRPIYYHEFVARHEFRKR
                     YWARSFIGWPGLLKAKPNSTHWAIKDIGTKGYISSVVTQNVDSFHSVAHPELPTLELHG
                     YLRSAVCINCRTQVPRDEFQQSLERLNPAWAEFLKKMVDIGALNADNPEEQRRRGLKIN
                     PDGDVDLPEAPYSTFRYPACPTCLEKPPRLQDGSQSRVEVERDGAWLPSSTAGILKPAV
                     IMFGENIDPAVRLGAEEAIDDAGRLLVLGSSLATYSAWRLVERAYKRGMPIGIINIGGV
                     RNESILFSKAEQETEAVCRHVRCSLPSQDILGPVAAQLPSLTHH"
     mRNA            join(12851..13075,13158..13181,13249..13971)
                     /gene="PHO85_1"
                     /locus_tag="CAN33_18615"
                     /product="negative regulator of the PHO system"
     gene            12851..13971
                     /gene="PHO85_1"
                     /locus_tag="CAN33_18615"
     CDS             join(12851..13075,13158..13181,13249..13971)
                     /codon_start=1
                     /db_xref="InterPro:IPR000719"
                     /db_xref="InterPro:IPR008271"
                     /db_xref="InterPro:IPR011009"
                     /db_xref="InterPro:IPR017441"
                     /db_xref="PFAM:PF00069"
                     /db_xref="PFAM:PF07714"
                     /gene="PHO85_1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs)
                     SMCOG1030:serine/threonine protein kinase (Score: 169.8;
                     E-value: 1.4e-51)"
                     /gene_kind="regulatory"
                     /locus_tag="CAN33_18615"
                     /note="GO_function: GO:0004672 - protein kinase activity
                     [Evidence IEA]; GO_function: GO:0005524 - ATP binding
                     [Evidence IEA]; GO_process: GO:0006468 - protein
                     phosphorylation [Evidence IEA]"
                     /product="negative regulator of the PHO system"
                     /protein_id="ncbi_CAN33_18615-T1"
                     /sec_met_domain="Pkinase (E-value: 3.6e-69, bitscore:
                     229.1, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MDMDGRDRSKSRTLQPPTADYLDLISNLASPKTFLFHPPRSTSRS
                     HPTPAAQSTTVAPSTTMDKQQPSSFQQLEKLGEGTYATVFKGRNRQTGELVALKEIHLD
                     SEEGTPSTAIREISLMKELKHESIVSLYDVIHTENKLMLVFEYMDKDLKKYMDTRADRG
                     QLDQATIMSFMHQLLKGIAFCHENRVLHRDLKPQNLLINKKGQLKLGDFGLARAFGIPV
                     NTFSNEVVTLWYRAPDVLLGSRTYNTSIDIWSAGCIMAELYTGRPLFPGTTNEDQLIKI
                     FRLMGTPSERSWPGISQLPEYKPNFHVYATQDLSLILPRLTP"
     mRNA            join(14956..15332,15434..15728)
                     /locus_tag="CAN33_18620"
                     /product="Nnf1 family protein"
     gene            14956..15728
                     /locus_tag="CAN33_18620"
     CDS             join(14956..15332,15434..15728)
                     /codon_start=1
                     /db_xref="InterPro:IPR007128"
                     /db_xref="PFAM:PF03980"
                     /locus_tag="CAN33_18620"
                     /note="GO_component: GO:0000818 - nuclear MIS12/MIND
                     complex [Evidence IEA]"
                     /product="Nnf1 family protein"
                     /protein_id="ncbi_CAN33_18620-T1"
                     /transl_table=1
                     /translation="MSTEPNPSAQRPGASPSPPPPAPVPLTPGPRASKLQEIFDKALAR
                     TLRANSYANFSGCFPTPAKHVPASLESVWRQLNAKLEESAKAEFEDILAERDAVRQLNE
                     LDRLVGEAKVRKDRGVGGDSVAPHTLSPEELYKAHLLPHLMETQADLDAKINSVQNQNA
                     ELAEKVQAQRSEIESLLSGLEAVVADLEGAAAATTQFTSEHQLRQEAAQMDGEVKARSE
                     I"
ORIGIN
        1 atgtctcacc atatggagga tgcacacaag cgacccaagg gtaaacaaac ctcttgcgat
       61 catccgcatc ctacgcctgg ttgctaatcg gacagcaggt attctgaaga actccagctc
      121 tcaggtgccc caggtcgcgc agcatgctca cgctactttg acgatccctt caacctcggc
      181 cgaccctacg gacaccaagg aacttacgct tcagaacacc ctccagaatg ccggtcgacg
      241 tcggtcgtca tccaacactc gccccgggtc ttcgtcgcga cgacagtctc ttgccagcat
      301 ccacggtcat cacgacgact cgtcgccccg cctgaagtgg gacgaggcca acctgtattt
      361 gacggagcag gagaagacgg ccaagatgaa gatcgatgag cccaagaccc cctatgcgcc
      421 gcgctatgac cccgccgagg atgaggacga gctggcgggc gaggaaagtc tgattgatgc
      481 gcaggatata gtggtggacg aactggacaa gacgaagaag gcgcccaaga agacggtcgc
      541 agaggacgat attccggagt tggagctggg agaggccgag gagtatggtg gtgatgcgca
      601 tatgggagat gccgatcgga tcgtgcgcga acgaagcttg agcaatgact cacatcgggg
      661 cgggaagcac gttgtggtcg gggctggcga gctgaacggc gaaaccgagt ctggtggaga
      721 tacgttgatg acggcgggcg aagccgagga aaagcatcgc cagttcgagc agcatcggaa
      781 gaagcactat gagatgcgga acatcaagga tctccttgcg taagttgctc ccctattccc
      841 aggatggctg tgggatttct catggaggta tggtatactg acgggctttg ttttccagcc
      901 accctgagga tctcgaggac gaaatggacg aagacgaaga tgagggggac agctcaagtg
      961 ccgcggtgcc gcccccgatg cctaggatcc cggagcgatt tctaaatgga ggaaagtgag
     1021 ggagcgaaag gaatggacgg acgggactaa gttatcactc tactcgagaa ggattaggac
     1081 gagaagaggt gataggaaaa taggatggag ggagggacta gttgattctt gctgcataaa
     1141 cggactctgt atattcccca gcgttgttta gtcatgatgg gacggacttg tatgaatcta
     1201 tgggaagtac tttgcttttt tttttttttt tttcttcttc tctagttgtt cactcttcct
     1261 gctagctgat gtggattgtg tcggctcttt tttttctctc atagcgaacg atgggttgct
     1321 tgatcgattg atagacgaga gagatgaaaa tgaaatgtac ggggagggga gagagttatg
     1381 gattattgac acgtcttgtt taaaaactag atacgatgaa gtaaatgagc tagctgtcag
     1441 ggaaataacc cacccgaagc agggagagtt ctagactgtt tgtctgacca cagcaggcca
     1501 ggggggactc gtcaccctcg gggttatatg agtcgcgtca aaaaatagaa tcatccaata
     1561 ctctgggaag tactccgtaa accgaatcaa accaacatag aagataaaaa aaaaaaaaga
     1621 aagaaaaaaa aaaaaaaata gggaaccaat gccattagag aaggtgataa gtagtcacct
     1681 tgagtccgcg gccagactac tctgagtaat agtgagttag agcacgcgcc tctccgctaa
     1741 gcccgaggct gtcaaatcat ccgaccacct gagacaagaa gaataattat agtatcagaa
     1801 tccaagagtc ggcatctcaa ccaaccctcg agtcggtgcc ttgcatgtca tctggaggaa
     1861 gtgagtggat gtgatcagtc accgcatgct gtaacctgtc aggggcattc tgggattttt
     1921 cttggtgagt ctgtctgtcg gtctctctct ctcctgaaac atccttgcag gcccactcca
     1981 agattcagga ggatgggatg gatcattttc ggtttcctag tcgagttgct attctgagta
     2041 acttggttag ttagttattc tactgtacta cggagtacta gctatgtact ctgtgtgtgt
     2101 gtgtgccttc cttcacttcc actcaatgga tcagatgttg aatcaagtat aaggtttgtg
     2161 ctgagttcta ctatcatcta gtagtgaaga gtcatggtat atgacttttc aaccatggga
     2221 tggatccata ttttaagttg tttgtttggt ctactctgga tctggtctga aaccttccag
     2281 atgacagaga aatcgataga taaataaaac aaatcagtta gttgtcttgt ctgatcgccg
     2341 ttgaaacctc ctaattgaaa ttaacggccg ctgcagcaat taattaatta atccactgct
     2401 atctctgatt ggattgcgcg cgttttctgt gctttcttag tttcgtcttt gcctgcttgt
     2461 cgcttcgctt cgtttctttc gcgctttctg tcttttctgg tctctcgtgt ttttcttctc
     2521 ttctcctctt cctcttttct cttcctctct ctctctctct ctctctctct ctctttttct
     2581 cccctgctgt tcatttccac ggctgttatt ggaaagccat cccgctcgcg tccgatcgca
     2641 tcacgcaatt ccatacattc attttaattc ttatttcccc tctctctatc tttcactaat
     2701 ctactgctac caaataatac atcccactac atccatcatg gccgatcagc ccgaaaagac
     2761 cgccgccgct cctgctgccc ccgaggcgca accccccacc accgccacta ctactaccga
     2821 gcctgcggtt tcggagtctc agactcaacc tgaacctcag ccagaagccg aacaaaaagt
     2881 cgagcaggcg acgacaggag aagaagcatc tcctgccccc gctgccacgg aacctcccgt
     2941 gacggaaccc actcccgctc ccgcccagga ggcccccgag gataagaagg aggaagcacc
     3001 caaggaagag accaaggaga ccaaggctga ggaatccaag gaggagcaga aggccgaaga
     3061 gcccgcggct gagcccaagg ccgaagcagc aaaggaggag gaacaaaagc ccgctcagcc
     3121 cgagtatctg gccaagaacc cggccctgag ccagttcttc gatcgtctgt ctgccattct
     3181 ctcctccact ggccacaatg agatgtgggg tgtcaccctc aaggactcct cggatgtccc
     3241 caccgtcaac attctcatca agttcctgcg cgccaacgag ggtaatgtca agctggccga
     3301 ggagcagctg actaaggccc tgcaatggcg caaggagatg aaccccctcg ccctgaccga
     3361 gggccgctac agtgctgagc gctatggtgg tctgggctat gtcaccaagt accccgaggc
     3421 gaatggcaag gagaccattg ttacttggaa cgtctatggt aatgtcaagt ctattgatca
     3481 gacctttggc gatgtagatg ggtaagtgct gctgctgctg ctgctgctgc tgctgctgtt
     3541 gctgctgctg ttgctgctat ttcggaattg aaaagagggt tagatctaac tgtcgcctag
     3601 gttcatcaag tggcgtgtcg cgctcatgga gctcgctgtc aaggacttga agttgagtga
     3661 ggcgacgacc gtgatcgact acgacggtga ggatccgtac cagatgctcc aggtccacga
     3721 ctaccagaac gtcagcttcc tccggctgaa ccccaccatc aaggcggcca gcaagaagac
     3781 catcgaggtg ttctccatgg cctaccccga gctgctgcgg gagaagttct tcgtcaacgt
     3841 gcctgccatc atgggctgga tgttcgccgc catgaaggtc ttcctcagca agaacaccac
     3901 ccgcaagttc caccccatct ccaacggtgc caacctggcc cgcgagttcc cttccctgaa
     3961 ggacaagttc cccaagacct atggtggtaa cggcgcgacc ctggaggagg atgcgttcac
     4021 ggtcaacctc gagaaggccg agcctgcccc ggaggctccc aaggaggagc ctaaggagga
     4081 gtccaagcag gagcaggccg aggctcccaa ggaagaggta aaggaggagg ccaaggagga
     4141 agccaagaca gagcagccgg cggccgagga gccggccaag gcagaggctg cagtgacgac
     4201 ccaggaggcg cccgccgcag cggaagccaa ataaaaagct agcaagaggc gtaattcaca
     4261 cctggtcgga atgaggccag gatcacataa tttacggtaa tggatgggac aggttggatt
     4321 gatacccggg ggaatcggta gaatgattcc gtgtcgtttt gcgtacttga tacctctcga
     4381 tagtgtgtgc tttatatgtt ctgggattga tgatggagtg cagaaacact agatagtaat
     4441 atttaatgta acaggtcata tagccgctga tttaacgtta cgatgtttct ctcgcgtcga
     4501 ccgttattcc atgcgttcct gcatgcagca gtaaactata acactggatt tcctgctctc
     4561 tttatgctga tctccagcca ggcacccctg atgactcagc agccagtgtc cctcagtttc
     4621 ctgcaccaac aaaaacacca actgcacagc tgctgcacga acaacaggca gcaaataaaa
     4681 tccgggcaag ggagattagt gtgttgttct tcctttctct cctctcgagt gtggttgtat
     4741 cctataagct atccctccca ctatccctct ctccactaat ctcaaccctg ccattccacc
     4801 ctttcaaccc cccccccccc cccccctccc ccccaatacc ataagtgtac aacaaccccc
     4861 catcacaatg tcgggatctc acatcggccc gtggagaact cccgcccaag gccatctcac
     4921 ccccgacgcc aacggcgatc tcaaaactga ctatacgcgc tggcgcctcc gcgacgaccg
     4981 cggccgccaa acctggcact acctggaatc cgacgcagag aacgagcaat ggcctcaatc
     5041 catcgcagat aagtacttct tgggtctccc cacgggactt cccgagctcc ccaaacccca
     5101 gacgcctctg caatgcgccg agaacgggct ggagttcttc tccaagttgc agctggagcc
     5161 gggaaattgg gcgtgcgagt atggcgggcc catgttcttg ctgcctgtct tgattatcac
     5221 gtactatgtt actaagacgc ctattccgcc ggagtatgcc accgagatta agcggtattt
     5281 gtttgctagg cagcatcctg aggatggcgg ctgggggttg catattgaag ctcacagttc
     5341 tgtgtttggt acttgtatga attatgttac gttgaggtta atcggtgtga gcgaggatga
     5401 tcctaggatg atcaaggcca gggggttgtt gcatcaattt ggaggtgcca tctatgggcc
     5461 ccattgggcg aaattctcgc tggctgtctt gggtgtgatg gattgggagt gtgtgaatcc
     5521 ggtgccgccg gagatttggt acgtttgttt ctatcatgtc tagtgggtga tttgtggatg
     5581 ggatactgat tcgaccaggc tacttcctga ctgggtgccg tttgcgccct ggcgctggtg
     5641 gattcatatt cgccaggtat ttctgcccat gtcgtatctg tggtctaaga ggttctcgca
     5701 tcccttggac cctctcacca agcagctgcg gcaggagctg tatacccagc cgtatgactc
     5761 gattgacttt gcggcgcatc gcaactcaat tcacaaggca gacaattact accccaagac
     5821 ttggctgctg aataccttga actctctgct cgtcaacatc tggaacccct accttcgtgt
     5881 ccctgccatt gtgcgtcgcg cggaggagtg gacgtgggag ttggtccgca tggaggacga
     5941 gaataccgac tacgctggcc tggggcctgt gagcaacccg ttcaacatga ttgtgtgcta
     6001 cgaacatgac ggtccggaca gctactcggt ccgtcgccat cgcgaacggc tgcacgacta
     6061 catgtggatg aaggacgagg gcatgctgat gaacggcacc aacggcgtcc aggtatggga
     6121 tacggccttt atcacgcaga gtatcgtggt ggccgggttc ggcgatgacc cgaaatggcg
     6181 gcccatgctc accaaggcac tggagttcct ggaagaccat cagctgcgcg agaacgtgcc
     6241 ggaccaggag aagtgctacc gccagcaccg caagggcgca tggccattca gcaacaagac
     6301 gcagggatac acggtcagcg actgcaccgc cgagggactg cgctcgacca tccagctgca
     6361 ggagatgcac aacttcccga aactgatctc ggaggagcga ttgaaggaca gcgtcgactg
     6421 cctgctcctg atgcagaacc ccactggtgg gttcaccgag tacgaaacca cgcgggcatc
     6481 cgagaaagtc gagtggctca acgcagccga ggtattcggc ggaatcatga tcggatacga
     6541 ctatcccgag tgcacgaccg cgtccgtcac cgcgctctcc ctcttcagca aatactatcc
     6601 gaattaccgg gccgcagaga tcaagtccgc caaggaaaag gccgttcagt acatcaagcg
     6661 ggtgcagcgc gccgatggca gctggtacgg gtcctggggc atctgcttca cgtacgcggc
     6721 gatgtttgcc ctggagagtt tggccagcat cggagagacg tacgagacga gcgcggactc
     6781 ccgacgcgga tgcgagttcc tcatctcgaa gcaaaaggag gacggcggct ggggcgagtc
     6841 gtacctcagc agcgagaagc acgtctatgt gcagcacgag aaatcgcagg tcgtgcagac
     6901 ggcatgggcc agtctggcat tgatggaggc cgggtatccg cataaggagc cgctgcggaa
     6961 agcaatgcag ctgctgatgt cgcggcagca ggccaatgga gagtggttgc aggagtcgat
     7021 tgagggagtg tttaaccaat cttggtgagt atcatgatcg attgattgag agttctccac
     7081 taacgagtga cagcatgatt tcgtatccca actataagct gtactggccg atccgggcgt
     7141 tgggattgta tgcgcgcaag tttggcaatg aggagttggt ctgatcttct atgaattgtt
     7201 cttctatgag tacatgtatt actactatac tactataacc ttctactaat tgataatatg
     7261 attcatgtat actatcttct ttatcgttga tctggagagt ttagatgtgt agccaatcac
     7321 gtggatgctc cgctccccgc atctctccaa agaagatcat cgaacttgtt tccattccat
     7381 tcacctctcc acttgtattc ctctttctct tacacattat ttccttttct cttcggagat
     7441 tcccttacaa acaacaagac tcatttttca catctcgtac tcagacccat acttaaaccc
     7501 tatctaccca cccaacaaac acaacacaac acagcacaac gcaacacctc catccaaaca
     7561 ccaccacact ccaacccacc acctcaaaac ctcaaaatga acgccgcctc cctcggcgac
     7621 accgccctcc aacagtccga cccccacacc gcaacaatcc actacacgac cgccctcctc
     7681 acgcaccccc gctcgcccag ctacttcatc aaacgctcaa cagccttctc acgcctaaag
     7741 cccacaccga acctctccgc cgccctccgc gatgccgaat ccgccgttct tctcgcccgc
     7801 gagcggggga aacgcgagct gatcgtcgag gcgcagatgc ggagagccat cgttttgttt
     7861 ctcatgggga gatacgttgc tgcggagggg gtggtaggcg tggtggaggg tatgattgga
     7921 ttggataagg acggtaatgg tggggaagat aaggaggaga aggtgaggaa ggcgatgggg
     7981 gtggtgctgg gaagggtatt gaggcggagg tgaggatttg gggggcgaag attagggcga
     8041 aggtcaacgg tttgggcgag cagagtggtg agcgtgggga gaaggtggag gaggttccgg
     8101 tgggggttaa agtgccgggg gagaaggagt tgaggggaca gttggaggag ttgaggggag
     8161 ggaaggttgg tgagggtatt ggtggtgaag agaagcagag tcagaaggtt gaggataagg
     8221 tggaggagaa ggggagagct gaggtcaagg agactcagca gcagcaacaa cagcagcagc
     8281 agcaggtcaa ggtccgtcat gaatggtacc agtccggtga gacggttgtt gtgacgcttt
     8341 acgtgaaagg cgtgcccaag gataaagtgg ctattgagct gaaagaggac tcggtatgta
     8401 ttcactcccc ttgactcaaa catgcaagtc actaacctat atacatagac atccatccaa
     8461 ttccccctcc cctccggcgc cgaatacgac ttcactctcg acccgctctt cgctcccatc
     8521 gacccctcca cctctaaagt ctccgtcttc tccacaaaga tcgaaatctc cctgcgcaag
     8581 aaaactcccg gccagaaatg gagcgccctg gaatctacca ccggacctgt catctctact
     8641 ccccagccca cggttacacc caccactacc accacacaag cccaagcccc atcatacccc
     8701 acctcctccc gccacggcgc caaagactgg gacaagctcg cctccagcct aacccagaaa
     8761 ccgaaaaagg acaagaccaa gagcagctca aagcccaagg atgaacaagg agaaggagaa
     8821 gaagacgatg gagaagcatc cgacgccgaa tccatcaact ccgacttcgg aggcggtgat
     8881 gccgtcgatg gcttcttcaa gaaactctat gccaatgcgg acccggatac ccgccgcgct
     8941 atggtgaaga gttacgtgga gagtcagggg acgtcgctga gtacgaattg ggatgaggtt
     9001 gggcaggggc cggttaaggt taggccgcct agtgagtgat tttctttctt cttttctttc
     9061 tcagtttctg agagaaagga aagaggggag caagaaagaa ttgttggttg aaagatggag
     9121 aagaaggggg tatgcgaatt gcaagcgtgg agttatggtc tacatccatg ttgtgggtgc
     9181 atgtgggtgg tgttttaggt tctgaagttg ctttccttgc tagttacttg ttttgtgtag
     9241 cttagcctta gcttagctct gctttacttg tgtaatggta atcattgcga gatgtcgaga
     9301 ctctgctatt acttaccttg taaacatgat acgtagacta ctacattata cacgtaatgt
     9361 agaagcgagt atagtataag ataataaata attatataca cgaaaagcaa ctccgatccc
     9421 accaagcgcc aatcacatga gcaagagtag catagcaacc tggccatata gcacgcaagc
     9481 gtttttagga taaatcatta taaatcaagc aatccctaag taccaacacc gacacctctt
     9541 tatgtcttcc cagaggcata atcaagaaaa acaagaataa acaagagaga atgtaaacca
     9601 catgcaaata ttttacctcg cctctgcatc cacctcaccc ccattcgcat cctggtacaa
     9661 gaaaaattga ataaagatac acatatccag caataacgtg ccaaagctcc caatcagcca
     9721 agacagattg accaggatat atcgaccata cagcgatgcc agttcatcag atcgacaccg
     9781 accatgatgc gagcgtccac acacaggcga atacgccaag atggaaagga cgtaggtcaa
     9841 attgccgata caggcgaaga ggaagaacag cagggaaaca ccgtctgttg acttgcggcg
     9901 ataattgagg aggatctgtg ggaggcggga accgaggtac aggactgcgc agaggtagcc
     9961 gaaaacttgg cctagtgtgt ccattttcag gtcatcaggg ctgtctttat gcttgttgtt
    10021 gttattcttg tccgatgaga gtgatgacgt ttggctgatg taccagccca ggatgccggc
    10081 ggcacagacg aggatgatgg ccgaaccgtt gaagaaggtg gcttggagca gtgttagggt
    10141 tcgaggggga cggggttgct tggctggttc gacgagtgga gtcactgggg agaggtgagt
    10201 tccgtcgacg gtcgtatgaa gaaatgaaga ggcggagtga cggcgatggg cgagcaaggg
    10261 ctggtggtga ggagtgatgg tagccgatga tgctgggcta cgagtgtcca aaggagcctg
    10321 gtaagaggca ctgcgttgtt tggaggtaag caacgcggtg cgctctgtgg gcttccgagg
    10381 cacgacaggg gagggaatct cagtgtcctc gtcgtaagtt tctgccgtga tgggagagac
    10441 aggccgcggc ggcgaggatg gttcgtcgcg cagtgtgaat ccccgatagt agaagcattg
    10501 tgctaagagc accacatcgg ctaaagtgta gtacaccgcg agaattatca tggttggcag
    10561 gacgccctgc aggacggcac cgaggatgtt gaacacatcg ccggcaagcc agacgatgag
    10621 gaaaagaagc gaaaggccat cagctgagcc gcgacgaaaa ttttcaatga tctgtgggga
    10681 gaagaccacc acccagcacg caatcgagat ggatctatca gtgatcagta ttgaacatgt
    10741 ccaattctag catactctgg cataaacata cccacatatg ccactcagtg cctctagatc
    10801 tatattgccg gtgactgcgg gaaacatgtc cgggcggtgc gaacgagaga gcgattgggc
    10861 gttttcccaa tcaatgctct actctataat ctaaacagga agaggctagc aaaactggtc
    10921 gacagcaaac aaagacgcgt tgatggaatg aagcagatgg ccggcgatga cgttcgcaga
    10981 gtctgcgaag ggtgcagatc acgtgggacg atccggggta gctcctctca gtctagacca
    11041 agaatggaca cccagatcga cttgcttcca cttttacttc ttttggctgg ggacgctttg
    11101 ttccttgtcg gccgcaatgc tctgtatcgt acattctggg ccttctggtc atctattact
    11161 atctgatcaa gtaatacttg gccccgtgta gtctgaccat ccatttcaca ctcaatggga
    11221 ctgtgtacat catgtgaccg attagtcaag ccgtgacgtc gatgatcaac cagcgcccat
    11281 ctgaacccag ccttctcgaa gcttcaacat ccatcaatca tgtggcttca atgactgctc
    11341 cagcaattcg gattcccttt acgggccctc tgcctccgcc gattattgtc cctccgtccg
    11401 ctcgcacggt cgcaggtgcc attgatgcgc ttttagcctt tttgacggcc ccaccgtcgc
    11461 cgtacctgcg cggcgttgat gtaggcaggc attcccagac agtgctcttg acaggcgctg
    11521 gtatctcggt agcttcaggc ctgtccgatt atcggggtga gaatggcacg tacatcacaa
    11581 ataagacgta tcggccgatc tactaccacg agttcgtcgc tcgccatgag ttccgcaagc
    11641 gatactgggc gcgaagcttc attgggtggc cggggctcct aaaggcaaag ccaaattcga
    11701 cgcactgggc tatcaaagac attggtacga aaggctatat tagttcagtg gtgacgcaaa
    11761 atgtcgactc cttccattct gtcgcgcatc cagaactacc cacactcgaa ctccacggct
    11821 acttgcgttc tgccgtctgc atcaattgtc gaactcaagt cccgcgagac gagttccagc
    11881 aatcgctcga gcggctgaac cccgcctggg cagagttcct caagaaaatg gtcgatattg
    11941 gcgcgctgaa cgcagacaac cctgaggagc agagacggag gggcttgaaa atcaacccgg
    12001 atggcgatgt agatttaccg gaggcccctt attcgacctt tcggtatcca gcatgtccga
    12061 cgtgcttgga gaagccaccc cgattgcagg atgggtccca atcccgtgtg gaggtagagc
    12121 gcgatggggc ttggcttcca agttctacgg cgggaattct gaagccggcg gtcattatgt
    12181 ttggagagaa tatcgaccca gctgtcaggc tgggtgcaga agaggccatc gatgatgcgg
    12241 gcaggctcct tgtcctgggc agcagtctcg ccacatactc ggcgtggcgc ctagtggaaa
    12301 gggcctataa acgagggatg ccgattggca tcatcaacat aggaggtgtc cggaacgagt
    12361 cgatcctctt tagcaaggcg gaacaagaga cggaggctgt atgccggcat gtccgttgca
    12421 gtctcccgtc ccaggatatt ctaggccctg tggcagcaca actgccttca cttactcatc
    12481 attagggtcc atgtatagat tgaaaaaaag gatgtgatgt atagatggcg gtgaggtgta
    12541 tgaaccgctt acagataagc atcatagtat atgtacaagc gataaaagtt gaatccaagc
    12601 ttgcattatt ggagacgtta ctattttcaa agtaactgta tccatcagat ggaatactct
    12661 agaaaagata attataggca ctccagaatg attggcaacg gcgagctaag ataggcatgt
    12721 aatagacgcc gggatagtgg agaccagcaa agtaggagaa ggcgagttac aaagtgatgg
    12781 cgggccagtc agccgcccgt ccgctgttcg attccagcgc ggggctctgc attcgccggt
    12841 tcagatcagc atggacatgg acggtcgcga ccgctcaaaa agcaggacat tgcaacctcc
    12901 aaccgccgat tatctggatc tcatctctaa cttggcctct cccaagactt ttctctttca
    12961 tcccccacgc tccacctctc gttctcatcc aactcctgct gcgcagagta ccaccgtcgc
    13021 accatcgacc accatggaca agcagcagcc cagctcgttc cagcagctgg aaaaggtgtg
    13081 ttttgatggc ttccctactg tctaccaaga tatcacccat caaatgagag atttgtgatg
    13141 ctaactgctg attctagctt ggagaaggca cctatgccac cgtacgaacc cctccctccg
    13201 cacggccgat cctcttaaat cgcactatgt actgacaccc tctcgcaggt cttcaaggga
    13261 cgcaatcgcc agactggcga gctggtcgcc ctgaaagaga tccatctcga ttctgaagag
    13321 ggaacgccat ccaccgccat tcgagaaata tcgttgatga aggagctgaa gcacgagagc
    13381 atcgtgtcgc tctatgatgt gattcacacg gagaacaaac tcatgctcgt ctttgagtac
    13441 atggacaagg atctgaagaa gtacatggat acccgcgccg accgcggcca gttggaccaa
    13501 gccacaatca tgtcattcat gcaccagctt ctcaagggca ttgcgttttg ccatgagaac
    13561 cgcgtcctcc accgcgatct gaagcctcaa aacctcctca tcaacaagaa gggacaactt
    13621 aaacttggag atttcggtct agcccgcgcc tttggcattc ccgtcaatac tttctccaac
    13681 gaagtcgtga ccttgtggta ccgtgcccca gatgtgcttc tgggcagccg cacatacaac
    13741 acgagcatcg acatctggtc tgctggatgt atcatggcgg aactctacac tggccgtcct
    13801 ctgttccctg gcaccaccaa cgaagaccag cttatcaaga tcttccgcct gatgggaacc
    13861 ccttcggaac gctcatggcc cggcatctcc cagctcccgg agtacaagcc aaacttccac
    13921 gtatatgcga cgcaggatct cagtctcatt ctccccagat tgacccccta ggtctggatc
    13981 tcttgagccg gatgctccag ctccggccag agatgcggat cagtgcccag gacgccctgc
    14041 atcacccctg gttccgcgat ctcccgcaat tgcaggccca attgcagcaa cagcagcagc
    14101 agcagcaaca acaacaacaa atggctgggg cgtatggtgg catggttccc ccacagcaaa
    14161 catattgagt tcttcctttg atgcgtttct gttttcctta tagttcgttt tcatcatgta
    14221 cagcctatcg tttaccttga cttgcgttca tctgcttcct cgtggaaggc ttgacgagca
    14281 acggattcgg ttttagaatg gggagcgcgg cgtttgactc ctgagaggac attcgaatga
    14341 ttcttgctgt tttctgcttt ctttgcgttg catatggacc cagagaaccg atggcatctc
    14401 gtagataaac ttggccatta tacttatcta ttgctctcta ttaccttcca ttatcgtagc
    14461 ttattacaag cgcagggaca gcagcgacga tatcttgtcc cgcagacaac taaatcaatc
    14521 ctgacaagcc tttatcagtg ccggatataa gccctaacat tccacgcaac caagttgaac
    14581 acagtagcta atctcggctc gccacgaaaa gacaacttac aataaggacc atccttatat
    14641 ttttcaaact gatttaaaca ctacaaatat acagtagcct acacatctta ctttataggt
    14701 acctaaactc tgtaatatat gtaggtactc cggtcttctg gcgggatcta tatctatcac
    14761 gtgattaata gtcgcgcgcg tcttccggcg cgtcctccaa tcccatcatc aatctactat
    14821 tctccataat cctacaacca cgaacaacaa caacacaaag gagcttgaaa cgaacttaag
    14881 gctcagcata acaaatcact gcaccccaat cgaaactctt caaccacctc aaaccctcaa
    14941 ccggcgaaag aaaacatgtc caccgaaccc aacccatcag cccaaagacc aggcgcctcc
    15001 ccctcaccac ctcctcccgc gccggtcccc ctaacaccag gcccgcgcgc ctccaaacta
    15061 caagagattt tcgacaaggc gctcgcgcgc acgctgcgcg cgaactcgta tgcgaatttc
    15121 agcgggtgtt ttccgacgcc ggcgaaacat gtcccggcta gcttggagag cgtgtggaga
    15181 cagttgaatg cgaagttgga ggagagcgcg aaggccgagt tcgaggatat tctggccgag
    15241 agggatgctg ttaggcagtt aaatgagttg gaccggttgg ttggggaggc gaaggttagg
    15301 aaggatagag gagtcggtgg ggatagtgtt gcgtatgtct ccccttcctt attccttttt
    15361 ttgctatttg gcatcattac attgggggcc tgtggatgat ggatggctaa ctggaatgat
    15421 ttgtgcttgg taggccgcat acgttaagtc cggaggaatt gtacaaagcg catctgttgc
    15481 cgcatctgat ggagacgcag gcggatttgg atgcgaagat taattcggtg cagaatcaga
    15541 atgcggagtt ggctgagaag gtccaggcgc agaggtctga gattgaaagt ttgttgtcgg
    15601 ggttggaggc tgtggttgct gatttggagg gtgctgcagc cgcgacgacg cagtttacga
    15661 gtgagcatca gcttcgacag gaagctgcgc agatggatgg agaggttaag gctagatctg
    15721 agatctga
//
