LOCUS       NKJJ01000022.1         22322 bp    DNA     linear   PLN 19-AUG-2019
DEFINITION  Aspergillus niger.
ACCESSION   NKJJ01000022
VERSION     NKJJ01000022.1
KEYWORDS    .
SOURCE      Aspergillus niger
  ORGANISM  Aspergillus niger
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Eurotiomycetes; Eurotiomycetidae; Eurotiales; Aspergillaceae;
            Aspergillus.
COMMENT     'Annotated using funannotate v1.6.0-df4262f'.
            ##antiSMASH-Data-START##
            Version      :: 5.0.0
            Run date     :: 2020-11-02 06:54:43
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 4778738
            Orig. end    :: 4801060
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..22322
                     /aStool="rule-based-clusters"
                     /contig_edge="False"
                     /core_location="join{[4788738:4789147](+),
                     [4789216:4789260](+), [4789292:4789447](+),
                     [4789515:4789906](+), [4790038:4790209](+),
                     [4790244:4791060](+)}"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      join(10001..10409,10479..10522,10555..10709,10778..11168,
                     11301..11471,11507..12322)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     cand_cluster    1..22322
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..22322
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="11"
                     /rules="(Terpene_synth or Terpene_synth_C or phytoene_synt
                     or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps
                     or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /tool="antismash"
     mRNA            join(434..5411,5470..5958,6026..6141,6194..6628)
                     /locus_tag="CAN33_49740"
                     /product="Acyl transferase domain family protein"
     gene            434..6628
                     /locus_tag="CAN33_49740"
     CDS             join(434..5411,5470..5958,6026..6141,6194..6628)
                     /NRPS_PKS="Domain: SAT (150-381). E-value: 3.9e-13. Score:
                     41.2. Matches aSDomain: nrpspksdomains_CAN33_49740_SAT.1"
                     /NRPS_PKS="Domain: PKS_AT (1621-1816). E-value: 1.6e-21.
                     Score: 68.6. Matches aSDomain:
                     nrpspksdomains_CAN33_49740_PKS_AT.1"
                     /NRPS_PKS="type: PKS/NRPS-like protein"
                     /codon_start=1
                     /db_xref="InterPro:IPR001227"
                     /db_xref="InterPro:IPR002539"
                     /db_xref="InterPro:IPR003965"
                     /db_xref="InterPro:IPR013565"
                     /db_xref="InterPro:IPR013785"
                     /db_xref="InterPro:IPR014043"
                     /db_xref="InterPro:IPR016035"
                     /db_xref="InterPro:IPR016452"
                     /db_xref="InterPro:IPR020801"
                     /db_xref="InterPro:IPR029069"
                     /db_xref="InterPro:IPR032088"
                     /db_xref="InterPro:IPR040883"
                     /db_xref="InterPro:IPR041099"
                     /db_xref="PFAM:PF00698"
                     /db_xref="PFAM:PF01575"
                     /db_xref="PFAM:PF08354"
                     /db_xref="PFAM:PF16073"
                     /db_xref="PFAM:PF17828"
                     /db_xref="PFAM:PF17951"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PKS_AT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1021:malonyl CoA-acyl carrier protein transacylase
                     (Score: 29.8; E-value: 4.4e-09)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="CAN33_49740"
                     /note="GO_component: GO:0005835 - fatty acid synthase
                     complex [Evidence IEA]; GO_function: GO:0004312 - fatty
                     acid synthase activity [Evidence IEA]; GO_function:
                     GO:0004318 - enoyl-[acyl-carrier-protein] reductase (NADH)
                     activity [Evidence IEA]; GO_function: GO:0016740 -
                     transferase activity [Evidence IEA]; GO_function:
                     GO:0003824 - catalytic activity [Evidence IEA]; GO_process:
                     GO:0055114 - oxidation-reduction process [Evidence IEA];
                     GO_process: GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /product="Acyl transferase domain family protein"
                     /protein_id="ncbi_CAN33_49740-T1"
                     /sec_met_domain="PKS_AT (E-value: 5.1e-20, bitscore: 68.6,
                     seeds: 1682, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MTATTELHPNPSPSPSGDGPSVAFTLEHGEATAALSVSSAVATTL
                     QPYRASWLADDTISPLSLTLSFLGHLTRQKAPLSAVQTAVRAFETQYLAGIDIHTAVTI
                     LPDALGAKKTALRDYYAAAAYTGQPLSNSPSALFKSAQTGTSRITTIFGGQGTANPSCV
                     RDLRSLYTTYRPILTQLMQECGPVLSSLSQRPDTQSYFRGRSIDLNSWLAGATTLNEDF
                     VSAAPVSLPILGLFDLAHYCVISSVLGQTPGQVATSMHAISGHSQGIVVAAAVARADSW
                     TSFYDNARLAVELLFWIGFESHQDAPQLFIAPELVEQTKEQGHGVPSPMLSVRGLERPA
                     LEKLLAQCNQVLPESRQLHIALINARTNHIVAGPAASLCGLSHVLAELQAAGEKDQTRI
                     PFSQRKPAVTHSFLPISTPFHTPYLQAASQRIKERLADRAFSADQLQVPVLHTATGEDL
                     RVNPQSNVIEALVDAITTEPVDFPGLLADATTTHFLVLGAGRLSELVKQIRQGYGQQII
                     AASELKPSSADIGSQADLFAPTLRPAPSSWADAYQPRLVQTANGRLILDTKLSRLLQVP
                     PIITAGMTPTTVPWDFVAAVINAGYFIELAGGGYHTEDEMRVAIEKIAAAIPPGRGITC
                     NLIYVNPKAIAWQTRLIRKLIRQGVPIDGLTIGAGVPSLEVAREYIDDLGIKHISFKPG
                     SVDAINAVLQIADDRPDFPIGLQWTGGRGGGHHSYEDFHAPILATYAEIRKRDNICLVA
                     GSGFGAGDDTYPYLTGQWSVARGYPAMPFDGILLGSRMMLCREAHTSPAVKQLLATTPG
                     VPDGEWEKSYKGSAGGIITVRSEMGQPIHKVATRGVRLWADFDQTLFRHPRPKMVEELA
                     KRKTEIIARLNKDYAKPWFGQDARGQPIDLADMTYAGVLARMVELMYVAHQQRWIHPSY
                     QRLVSDVAVRTLERVAPSVELSLDLLDAPASFLQVLSEKCPAAATQRLHPDDAAFFLRR
                     CQARGQKPVNFIPILDENFETWFKKDSLWQSEDLEAVVGQDPERVCILHGPVAVRYATD
                     KDESAQEILDGIATSHTHAALQDFYRGDLQRVPKVVNASAATSHTQPESSYEVSSLDLV
                     TDSSFSWVRDLLETPTIIREGIRKKNTFRSILAVKPGQKLVVNHTQQRIVLCESSTEQP
                     VISIQSDGTRTISVDLHQPSSFTAAPAVLSLQYKARSAGLSPALEEVVDGRNDRIKTFY
                     RNLWLGEAADPTKDSHSTFHGPEITLTRDLLEDMYRTLGLSPTGIRPESLPMDIAIVIA
                     WEPLVEPLVCAGVEGDLLRLVHRSNDIDYVPSATPFQVGDVLRSSSQIQSITIEPTGKS
                     IVVKATIERAGEPIAFVTSTFFMRGTYTDYASCFERITEPETMLEVSTPVDEELLRSRP
                     WLQLDEPTTPLVGKTLCFRLETSIDWKDQTTFQTLQTSGTVSLRSWNGKQTPIGRVSFE
                     ARDGKANPVSDFLRRRGQPLVARKPLEVTQELNQTSEGVQIPASNAGYSTFSKDFNPIH
                     ISSEFAQYVELPGTITHGMYTSAVVRAVTERCAAQGDLTRFRRWACSFVGMVLPSDQLE
                     VRVQHVAMIEGRLLLNVTAIKAGTDEAVIQAEAEVDQPSTVYVFTGQGSQSPGMGMSLY
                     KSSAAARAIWDAADKFFIETYGWSVLELVRQNPTALTVHFRGKRGRQIKANYMAMTIDA
                     YRADGTLVKEPILPELTPKSTSYTFADPRGLVFSTQFAQPLVLLLERAAVEDLRQRGVV
                     QGDAAFAGHSLGEYGALASFGEFMPFTDLLRVVFYRGLAMQVAIERDDQGRTNFSMAAV
                     NPARVGKFFTEKALRQIVTQIATTTHALLEIVNFNVDGEQYVCAGTLENLHALAAITDT
                     IARSPTGAALAREFTDATTIGNADLASTKLVEQCIAEARQLPAPVSLKRSLATIPLQGI
                     DVPFHSAHLRPGVASYRNFLEERIPKTEVDPQKLVGKWIPNVMGTPFSLSREYVEGVYG
                     LTQSPILKEVLAR"
     aSDomain        884..1576
                     /aSDomain="SAT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CAN33_49740_SAT.1"
                     /evalue="3.90E-13"
                     /label="CAN33_49740_SAT.1"
                     /locus_tag="CAN33_49740"
                     /score="41.2"
                     /tool="antismash"
                     /translation="IFGGQGTANPSCVRDLRSLYTTYRPILTQLMQECGPVLSSLSQRP
                     DTQSYFRGRSIDLNSWLAGATTLNEDFVSAAPVSLPILGLFDLAHYCVISSVLGQTPGQ
                     VATSMHAISGHSQGIVVAAAVARADSWTSFYDNARLAVELLFWIGFESHQDAPQLFIAP
                     ELVEQTKEQGHGVPSPMLSVRGLERPALEKLLAQCNQVLPESRQLHIALINARTNHIVA
                     GPAASLCGLS"
     CDS_motif       887..928
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CAN33_49740_0001"
                     /evalue="9.80E+00"
                     /label="PKSI-AT-M_m1"
                     /locus_tag="CAN33_49740"
                     /score="0.2"
                     /tool="antismash"
                     /translation="FGGQGTANPSCVRDL"
     CDS_motif       1211..1267
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CAN33_49740_0002"
                     /evalue="1.70E-03"
                     /label="PKSI-AT-mM_m3"
                     /locus_tag="CAN33_49740"
                     /score="11.3"
                     /tool="antismash"
                     /translation="HAISGHSQGIVVAAAVARAD"
     CDS_motif       5291..5347
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CAN33_49740_0003"
                     /evalue="1.60E-05"
                     /label="PKSI-AT-mM_m1"
                     /locus_tag="CAN33_49740"
                     /score="17.3"
                     /tool="antismash"
                     /translation="VYVFTGQGSQSPGMGMSLYK"
     aSDomain        join(5297..5411,5470..5939)
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CAN33_49740_PKS_AT.1"
                     /evalue="1.60E-21"
                     /label="CAN33_49740_PKS_AT.1"
                     /locus_tag="CAN33_49740"
                     /score="68.6"
                     /specificity="Minowa: trans-1,2-CPDA"
                     /specificity="PKS signature: (unknown)"
                     /specificity="consensus: pk"
                     /tool="antismash"
                     /translation="VFTGQGSQSPGMGMSLYKSSAAARAIWDAADKFFIETYGWSVLEL
                     VRQNPTALTVHFRGKRGRQIKANYMAMTIDAYRADGTLVKEPILPELTPKSTSYTFADP
                     RGLVFSTQFAQPLVLLLERAAVEDLRQRGVVQGDAAFAGHSLGEYGALASFGEFMPFTD
                     LLRVVFYRGLAMQVAIERDDQGRTNFSMAAVNP"
     CDS_motif       5772..5882
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CAN33_49740_0004"
                     /evalue="7.20E-06"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="CAN33_49740"
                     /score="17.9"
                     /tool="antismash"
                     /translation="AFAGHSLGEYGALASFGEFMPFTDLLRVVFYRGLAMQV"
     tRNA            7378..7448
                     /locus_tag="CAN33_56610"
                     /product="tRNA-Gly"
     gene            7378..7448
                     /locus_tag="CAN33_56610"
     mRNA            join(10001..10409,10479..10522,10555..10709,10778..11168,
                     11301..11471,11507..12322)
                     /locus_tag="CAN33_49745"
                     /product="Polyprenyl synthetase family protein"
     gene            10001..12322
                     /locus_tag="CAN33_49745"
     CDS             join(10001..10409,10479..10522,10555..10709,10778..11168,
                     11301..11471,11507..12322)
                     /codon_start=1
                     /db_xref="InterPro:IPR000092"
                     /db_xref="InterPro:IPR008949"
                     /db_xref="PFAM:PF00348"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: Terpene_synth_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182:Polyprenyl synthetase (Score: 126.3; E-value:
                     2e-38)"
                     /gene_kind="biosynthetic"
                     /locus_tag="CAN33_49745"
                     /note="EggNog:ENOG41; GO_process: GO:0008299 - isoprenoid
                     biosynthetic process [Evidence IEA]"
                     /product="Polyprenyl synthetase family protein"
                     /protein_id="ncbi_CAN33_49745-T1"
                     /sec_met_domain="Terpene_synth_C (E-value: 3.6e-06,
                     bitscore: 23.2, seeds: 87, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MFKQYSHILSHKRRRSRGSTINQVLSGAQSEPASEAATVSEPVEV
                     WTHSQVLPEDDEHRKDCFTTLTPRIHKYDHVAQRGSDRFVQDLTAALNLDEPQTSYLSS
                     PVGNYASFLYPECLPERLETVAYLTELGNLHDGKQQGKKTDESAESPAMSELSDKDKDG
                     HEIIDCYRSNWLVTPEVPTAENCANLDDYVARRRLNAGIDVYWTLMGFAHGTRLGKEDQ
                     AVVRDALDAAERTMFFTNDYYSWPKEKRVSKKKPVANVILFLMEHQNMSEEDAVAKAKQ
                     LIIDNEHEFVRRREALYQANSDLAPQLRKWMEVLGASLAGIHYWCKNAPRYAAAPVEVV
                     PEPEESEEPVEVAVWTPLVTEEETPDVHLDTSALLAPAATPARFPAAPCTVPARPLAFI
                     RQVITELQDSTGMLADVQDQAALRDQRTPAHLVYGPAQCMNSAAYLFVRAARIVTSLNC
                     PGMLDGLLQELEAHFVGQSWELNWRFSTHCPGETEYLAMVDQKAGASFRLLTRLMQAAS
                     MGGATLDLEPFTKVLGRLSQIRHEYLGLLESAASDRSFGEDLDQAKVTYPIVRACNLDP
                     AGRAVIFGIFRQKPAGTVLPIESKRQIVSLVQQTGALQATYDLIRQLGREAMNTLSELE
                     TAAEELNPSLRAVVKSLVEVPAPDHL"
     mRNA            complement(join(12603..13468,13498..13737,13800..14133))
                     /locus_tag="CAN33_49750"
                     /product="Aldehyde dehydrogenase family protein"
     gene            complement(12603..14133)
                     /locus_tag="CAN33_49750"
     CDS             complement(join(12603..13468,13498..13737,13800..14133))
                     /codon_start=1
                     /db_xref="InterPro:IPR015590"
                     /db_xref="InterPro:IPR016160"
                     /db_xref="InterPro:IPR016161"
                     /db_xref="InterPro:IPR016162"
                     /db_xref="InterPro:IPR016163"
                     /db_xref="InterPro:IPR029510"
                     /db_xref="PFAM:PF00171"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017:aldehyde dehydrogenase (Score: 418.4; E-value:
                     5e-127)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="CAN33_49750"
                     /note="GO_function: GO:0016620 - oxidoreductase activity,
                     acting on the aldehyde or oxo group of donors, NAD or NADP
                     as acceptor [Evidence IEA]; GO_function: GO:0016491 -
                     oxidoreductase activity [Evidence IEA]; GO_process:
                     GO:0055114 - oxidation-reduction process [Evidence IEA]"
                     /product="Aldehyde dehydrogenase family protein"
                     /protein_id="ncbi_CAN33_49750-T1"
                     /transl_table=1
                     /translation="MSQSIPQHPGQRENIETRLFINGEFVPSLSGSKFDLYNPATEELS
                     ASVYEAGPEDVDRAVAAAKAAFPAWSETGALQRAQLLEKWADRLEACADEMAYLDAICM
                     GKPAYSDNVGRIMPLFVRVYAAKALDITGESSLNTPGFVNVSLRQPFGVCGAIVPWNGP
                     VVTMIFKAAAALVTGNTIVIKSSEKAPLRSRHPPGVFNMLSGFGRPCGEAIARHMEIRK
                     ISFTGSTATGRAIQKMAAESNLKSVTLELGGKSPLVIWDDADLSKAVPAAAMSILTNSG
                     QVCVASSRVYVHEAIAPQFLEQLKTTMTEMGKSGHPLIPGTTRGPQADAAQFARVQGYL
                     DLAKQEGVSVYLGGEREGDKGYFVQPTILKDVPEESRLMKEEIFGPVVAVNTFTDEEDV
                     MARANDSEYGLYASIYTRDISRALRAAKKFEAGTVGVNCTSPTMAFDMPFGGWKGSGEG
                     RELSRYATDYWTELKSVLIAL"
     mRNA            join(15391..16102,16298..17199)
                     /locus_tag="CAN33_49755"
                     /product="Macro domain family protein"
     gene            15391..17199
                     /locus_tag="CAN33_49755"
     CDS             join(15391..16102,16298..17199)
                     /codon_start=1
                     /db_xref="InterPro:IPR002589"
                     /db_xref="InterPro:IPR026590"
                     /db_xref="InterPro:IPR029035"
                     /db_xref="PFAM:PF01661"
                     /locus_tag="CAN33_49755"
                     /note="EggNog:ENOG41"
                     /product="Macro domain family protein"
                     /protein_id="ncbi_CAN33_49755-T1"
                     /transl_table=1
                     /translation="MTGSLPSVLQTLLADSHYFSLQRSVCHHNHHRQHDIASIESMDSW
                     AQFRLMKQLLCVRHPRQSLPSSLLREIDQVLLEERANRLLLDAASIPALPTPSSSSKPL
                     PATLHLWQGDITTLDGVTAITNAANEQMLGCFQPAHRCLDNVIHARAGPRLREECFHHM
                     DQGQRTLPVGHACATKGYCLPAPYVIHTVGPQLDAGQPVPTAHQRQQLRQCYEAVLDVA
                     EALPASDPRGKSIALLPPPRVHGSSLIQAKAWLAAADTILISCGAGISAATGLDYTSTT
                     LFDRHFPAFKQYQLRRLYDTFGRTNRDWPSESVRWGFYFSHLAMVRRWPRSSLYTSLLK
                     WLASRFQPDRVHVRTSNADGLFAAHGLPEAQLSTPQGQYAFLQCLENCRPDAVFPSAPY
                     LDAALPHLDPQTQVVTAQDKIPTCSFCGGAMSICVRAGDWFNERPFAPGETRWHQFREA
                     FLTDLTRNVVIIELGVGLSTPGVLRWENEELIEQGDGRVRLVRAGLGDAVQVPGELAAA
                     QLATSIEGDLQDVVRAIVAP"
     mRNA            join(17807..17866,17926..18421,18481..19584,19641..19918)
                     /locus_tag="CAN33_49760"
                     /product="Flavin containing amine oxidoreductase family
                     protein"
     gene            17807..19918
                     /locus_tag="CAN33_49760"
     CDS             join(17807..17866,17926..18421,18481..19584,19641..19918)
                     /codon_start=1
                     /db_xref="InterPro:IPR002937"
                     /db_xref="InterPro:IPR036188"
                     /db_xref="PFAM:PF01593"
                     /locus_tag="CAN33_49760"
                     /note="EggNog:ENOG41; GO_function: GO:0016491 -
                     oxidoreductase activity [Evidence IEA]; GO_process:
                     GO:0055114 - oxidation-reduction process [Evidence IEA]"
                     /product="Flavin containing amine oxidoreductase family
                     protein"
                     /protein_id="ncbi_CAN33_49760-T1"
                     /transl_table=1
                     /translation="MPRYNWWYSPLVLGVIYSALVPSLVTADSLHNVHLDFLDSSFEGH
                     INLFYGDCHTGQGHHEIGHIVIERDAHPERFVWITPADAPHLHCLHAISGSTLLARSDP
                     IPIATRLARRESIADVADVMGPWFDGVAYMQGKEPGKAVVSAAKNSSVAIIGGGISGMM
                     TSLLLNSVGMTNWHIVESSHRLGVGAMRLPMNITYADTNETLQIQDMRLVLQLADVLNE
                     LNADADPALRVNFIPFIQDNPNLPTDTGGVRLPDGRIPTVAQVAANSSLAYTAPPDNAS
                     AVADAKAQYMQYAQTDKMGKIREVARNMYRAHKAALEDGFYHWSEAAYMRYALGENADV
                     VDYAAGTANNPIWDGFYDSVYFAATTWFTIDQGMESLVRAFLPHVADKATLGRKVDGLS
                     YNESSGKIAYTWRDSPVQITPERSEEYDYAVVAAPFTKVRMWELPRYSSILSRAISETN
                     YEPACKLALLYKTRFWEYQEQPIFGGCGTVDIPGVQYVCYPSFNLNGTGPAAVLGAYSH
                     GSPARSVQALKLEDWVALARRSMVEIHGAIAEEQFTGISHGHCWENDEHQNGAWTHPLV
                     GQQEIFLPAYYQTEFQTIFVGEHTTYTHGWIAAALDSAVRGTTQLLLDLGLVDEAKAIV
                     HEWMGRWIEL"
     mRNA            complement(join(20360..20419,20480..21550,21598..21767,
                     21818..21952,22004..22172))
                     /locus_tag="CAN33_49765"
                     /product="major facilitator superfamily protein"
     gene            complement(20360..22172)
                     /locus_tag="CAN33_49765"
     CDS             complement(join(20360..20419,20480..21550,21598..21767,
                     21818..21952,22004..22172))
                     /codon_start=1
                     /db_xref="InterPro:IPR011701"
                     /db_xref="InterPro:IPR020846"
                     /db_xref="InterPro:IPR036259"
                     /db_xref="PFAM:PF07690"
                     /locus_tag="CAN33_49765"
                     /note="EggNog:ENOG41; GO_component: GO:0005887 - integral
                     component of plasma membrane [Evidence IEA]; GO_process:
                     GO:0055085 - transmembrane transport [Evidence IEA]"
                     /product="major facilitator superfamily protein"
                     /protein_id="ncbi_CAN33_49765-T1"
                     /transl_table=1
                     /translation="MADKKIDVDCIEHVDQVLVDEAGRIQRLPVPSDDPNDPLNFALWE
                     KTGIVVCCCWFSIMSLSVIGGLGSVLDVFFQMYGAEGHSTNQVVWLSTFPSLFVGIGNY
                     IILPLALVCGRRPVMLIANTVLLGSLIGCALSQNWAQHFGLRILLGFATGATESLLPLM
                     LAEVTFIHQRGTIYGIYWATQNIVTSLLTLASSYEVAALGWRWFYWVFVITVAVGLVLV
                     VFACFETRFQRRPIFVGDHAVVTDQYGVTRVLTATETQEYLTSEEGRSYADLDGDTPPK
                     KTYRQMLSAWPRLCPHPLRDVLLTWWQMLETFSSPGIIYATLLSAVILGGSVGVSLTYD
                     TVLQYNYGWGAASIGLINLGGVFGGLGGMLYAGILGDRVIVWLARRAGGVHKPEHHLLL
                     LIFPGLLAVASLLLYGFTASGDATWGGPFMGWTLYQVAFVSTLIRTTSFATEAWEKNPG
                     PALVTVVGTKNIIGFGVSYGLNPMVAKYSYPAATGILAGVVGGVLLLGVPVYFYNPMWR
                     RYISQQRTRDRGQSGGP"
ORIGIN
        1 gtagggcttg cgcgagttgt cgtcggcggc aggaatgaca gtcatgctgg acggggcaat
       61 gattggagga taagagaacg cactagatct tctctctcct cttcctttca atgaggaatc
      121 atttgttgcc tttcaagtac tttatgaaat gttgcattca gggcagtggc gggccggatc
      181 ttgcatcctg gcgtggttcg ggtttcggcc gccggatgag actctgcagc aacaccgaat
      241 caattgctga gagatgcttt tgctgccgaa cagctttcaa tcggcaggat ttggtctgtc
      301 tgactcagct atcgaagcaa tgtgagacaa cgaagtcagt cttataatcg acctcaaaag
      361 ctatctatct ctggcctctt cttcttgccc aggttgttgt tatcccgacc aaatgtcgcc
      421 ctagtcaccc accatgactg cgacaaccga gcttcatccc aacccttcac cctcgccttc
      481 tggggatggg ccatccgtgg cttttaccct cgagcatggc gaggccactg ccgcgctgtc
      541 tgtgagtagt gctgtggcca ccacactgca gccctaccgc gccagctggc tggccgacga
      601 caccatctct cccctcagtc taacgctgtc cttcctcggc catttgaccc gccaaaaagc
      661 ccctctatcg gcagtccaga ccgctgtgag ggcctttgaa acacagtatc tcgcaggcat
      721 tgacatccac acggctgtca ctatcctgcc agacgccctt ggtgccaaaa agactgccct
      781 gcgggattac tatgccgccg cagcctatac cggtcagccc ttatccaact cacccagtgc
      841 cttgttcaaa tccgcccaga caggcacctc acgcatcaca acaatctttg gcggccaagg
      901 aacggccaat ccatcgtgtg tgcgcgattt acggtctctc tataccacct accgccccat
      961 actcactcag cttatgcaag aatgtggccc tgtcctgtcc tctctgtccc agcgcccgga
     1021 cacacagtcc tactttcgcg gtcgttctat cgacttgaat tcctggctgg ccggcgcaac
     1081 aaccctcaat gaggactttg tcagcgccgc gcctgtcagc ctgcccattc taggactctt
     1141 cgacctggcc cactactgcg tcatctccag tgttttgggt cagacccccg ggcaagtggc
     1201 tacttcgatg catgccatct ctggccattc ccagggcatt gttgttgccg ctgctgtggc
     1261 tcgtgccgac tcgtggacat cgttctacga caacgcccgg ctggctgtcg agctgctgtt
     1321 ctggattggc tttgagagcc accaagatgc gcctcagttg ttcatcgcgc ccgagcttgt
     1381 tgagcaaacc aaggaacaag ggcatggagt tccttcgcca atgctttccg ttcgaggact
     1441 tgagcggcca gcactggaaa agcttctcgc ccagtgtaat caggttctcc ctgagtcgcg
     1501 ccagctgcat atcgccctca ttaatgcccg cacaaaccac atcgtcgcag gtcctgcagc
     1561 gtcactgtgc ggtctcagtc atgttctcgc cgagctgcaa gccgctgggg agaaggatca
     1621 gactcgcatc cccttcagcc aacgcaagcc cgccgtcacc cactccttcc tccccatcag
     1681 cactcctttc cataccccct acctgcaggc agcgtcccag cgcattaagg agcggcttgc
     1741 cgatcgcgcg ttttccgcag accagctaca agttcctgtt ttgcacaccg cgacgggtga
     1801 agatctacga gtcaaccctc agtccaatgt cattgaagcc ctcgtggatg ccatcaccac
     1861 cgagcccgtt gacttccccg gtctgttggc cgacgcaacc accacccact ttctcgttct
     1921 cggggctggt cgcctcagcg agctagtcaa gcaaattaga caggggtatg gccagcagat
     1981 catcgccgcc agcgagctca agccttccag tgccgacatc ggtagccagg ccgacctctt
     2041 tgcaccaacc ctccgcccgg ctccttcatc ctgggcggac gcctatcaac ctcgcctggt
     2101 gcaaacggcc aacggccggt tgatcctcga tacgaaactc agtcgcctgc tgcaggtacc
     2161 cccgatcatc accgccggta tgacgcccac taccgtgccc tgggacttcg tggcagctgt
     2221 catcaacgct ggttacttta tcgagctggc cggcggaggc taccacaccg aagacgagat
     2281 gcgggtcgcc atcgagaaga tcgctgccgc cattcctcct ggccgcggca ttacctgcaa
     2341 tctcatctac gtcaatccca aggcaatcgc ctggcagaca cggctgatcc gcaagctcat
     2401 ccgccaagga gtacccattg acgggcttac tatcggtgcc ggtgtgccgt cgctcgaggt
     2461 tgctcgcgag tacatcgacg accttggcat caagcacatc tccttcaagc ctggatcggt
     2521 cgatgccatc aacgctgtgc tgcagatcgc tgatgaccga cccgacttcc ccatcggact
     2581 ccagtggacc ggtggccggg gaggcggcca tcactcgtat gaggacttcc acgcgcccat
     2641 cctggccacc tacgcggaaa ttcgcaagcg tgacaacatc tgcctcgttg ccggcagtgg
     2701 atttggtgct ggagatgata cctaccctta cctgaccggc cagtggtcag ttgctcgggg
     2761 ctaccccgcc atgccgtttg acggtatttt gttgggcagc cgcatgatgc tttgtcgcga
     2821 agcccacacc agtccagcag taaagcagct gctcgccacc acacccggtg ttcctgatgg
     2881 cgagtgggag aagagctaca aaggcagcgc gggtggcatc attacagttc ggtcggaaat
     2941 gggccagcct atccacaagg tggccacgcg aggagtccgg ctgtgggccg actttgacca
     3001 gacgctgttc cgccaccctc gtccgaagat ggtggaggag ctggccaagc gcaagactga
     3061 aatcattgcc cggctgaaca aggattatgc caaaccctgg tttggtcagg atgcccgtgg
     3121 acagccgatt gacctggcag acatgactta tgctggagtg ctggcccgca tggttgagct
     3181 gatgtatgtg gcccatcagc agcgctggat ccatccgtca taccagcgcc tggtgtcaga
     3241 tgtggccgta cgcaccctcg aacgcgtcgc tccgtccgtg gaactgagcc ttgatctgct
     3301 ggatgcacca gctagtttcc tgcaggtgct gtccgagaag tgtccagctg ctgccacgca
     3361 acgcctgcat cccgacgatg cggctttctt cctgcggcgc tgccaggcgc gtggccagaa
     3421 gcctgtcaat ttcattccga ttctggacga gaacttcgaa acatggttca agaaggattc
     3481 gttgtggcag tcagaggacc tggaggccgt cgtagggcag gatcctgagc gcgtgtgcat
     3541 cttgcatggc cctgttgccg tccgctatgc caccgacaag gacgagtcag cccaggagat
     3601 cctcgacggc attgcgacct cgcataccca cgcggcactg caggactttt accggggtga
     3661 tctccaacga gtgcctaaag tcgttaatgc atctgccgcc acctcccata cccagcccga
     3721 atcttcgtat gaagtgagct ccctggatct ggtgacagac agctctttta gctgggtacg
     3781 tgaccttctc gagacgccta ctatcatccg cgaaggcatc cgcaagaaga acacattccg
     3841 cagcatcctg gctgtaaagc caggtcagaa gctggtcgtc aatcacacgc agcagcgcat
     3901 cgtcctctgt gaaagcagca cggaacagcc agtgatcagc atacaaagcg atggtaccag
     3961 gaccatttct gtggaccttc atcagcccag cagctttacc gctgcccctg cagtcctctc
     4021 actccagtac aaggctcgtt ccgctggact ctctccagcg ctggaggagg ttgtagacgg
     4081 acgcaatgac cgcatcaaga ccttctaccg caacctttgg ctgggagagg cggcagaccc
     4141 taccaaggat agccactcca ccttccacgg acctgagata accctcactc gcgacctgct
     4201 cgaggacatg taccggactt tgggtctttc gccgacgggc atccgaccgg aatctctgcc
     4261 catggacatc gccattgtga tcgcctggga accgctggtc gagccgcttg tctgcgcggg
     4321 agttgaaggg gatctgctgc gactcgtgca ccgctccaac gacattgact atgtgccctc
     4381 cgctacacct ttccaggtcg gagatgtcct gcgctcgagt agccagatcc agtccatcac
     4441 cattgagccg acaggcaagt cgatcgttgt gaaggccacc attgagcggg ccggagaacc
     4501 catcgccttc gtcacctcca ccttctttat gcgcggcaca tacaccgact atgcctcctg
     4561 ctttgaacgc atcaccgaac cggagaccat gctcgaggtc tctactcccg tagatgagga
     4621 gctgctgcga tcccgaccgt ggcttcagtt ggatgaaccc acgaccccgc tcgtcggcaa
     4681 gacgctctgc ttccgactgg agacatccat cgactggaag gatcaaacga ccttccagac
     4741 acttcaaacg agcggtactg tctccctccg ctcctggaac ggcaagcaaa cgcccatcgg
     4801 tcgggtctcc ttcgaagctc gcgacggcaa ggccaatccg gtgtcggact tcctacgtcg
     4861 acgcgggcag ccactggtcg ctcgcaagcc gctcgaagtc actcaagagc tgaaccagac
     4921 ctcggagggc gtgcagattc ccgcatccaa cgcgggctat agtaccttct ccaaggactt
     4981 caatcccatt cacatctcgt ctgagtttgc acagtatgtt gagttgcctg gcactatcac
     5041 tcatggcatg tacacgtcgg ctgtggtacg cgcagtcact gagcgctgtg cggcgcaggg
     5101 tgatctgaca cgtttccgcc gctgggcctg ctcgtttgtc ggcatggtgc tgccgagcga
     5161 tcagctggaa gtgcgcgtac agcacgtcgc tatgatcgag ggacgattgc tgctgaatgt
     5221 gacggccatc aaggctggga cggatgaagc ggtcatccag gcggaggccg aggtggatca
     5281 gccctcgacg gtgtatgtct ttaccggaca aggcagccag tcgccaggca tggggatgag
     5341 cctgtacaag tccagtgcgg ctgcccgggc catctgggac gcagcggaca agttcttcat
     5401 tgagacctac ggtatgtaat accccttgtt tttctgtatc ccctctagca agctaataat
     5461 ggcattcagg atggtcggtt ctcgagctcg tccgccagaa tccaacagct ttgacggtgc
     5521 acttccgggg caaacgcggg cgtcagatca aggccaacta tatggccatg actatcgatg
     5581 catacagggc cgatggaacg ttggtgaagg agcccattct tccggaactc acgcccaagt
     5641 ccacttcata cacatttgcc gacccgcgcg gtttggtgtt ctcgacgcag tttgcacagc
     5701 ctctggtctt gttgttggag cgcgcggcgg tcgaggatct ccgccagcgg ggagtagttc
     5761 agggggatgc tgcgtttgca ggacactcac tgggcgaata tggagcattg gcatcgtttg
     5821 gcgagtttat gcccttcacg gatctcctgc gagtggtgtt ctatcggggt ttggccatgc
     5881 aggtggccat tgagcgcgat gatcagggac ggacgaactt ttccatggcg gcggtgaatc
     5941 cggctcgtgt gggcaagtgt gagtaaccat tgatactctc ctgtgtggat gtggggttta
     6001 ccgtgaatgc tgacatgggg tttagtcttc acggagaagg cattgcggca gattgtgaca
     6061 cagatcgcta cgacaacgca cgccctgctc gagattgtca acttcaatgt cgatggcgag
     6121 caatatgtgt gtgctggaac ggtgagttct ctttccccca caacgaggta tgttctttcg
     6181 ctcatgatat cagctcgaga acctccatgc cctggccgcc atcaccgaca ctattgcgcg
     6241 gtctcctact ggggctgctc tcgcacgcga atttaccgac gctaccacga tcggtaatgc
     6301 agaccttgca tcgacgaagc tggtagagca atgcattgcg gaagcacgcc agctccccgc
     6361 gccagtgagc ttgaagcgca gcctcgcgac aattcccctg cagggcatcg acgtgccctt
     6421 ccactcggca catctgcgac cgggagtggc atcgtatcgc aacttcttgg aggaacgtat
     6481 ccccaagact gaggtggatc cgcagaagct ggtgggcaag tggattccca atgtaatggg
     6541 gacgccgttc tcgcttagtc gggagtatgt cgagggggtg tatgggctga cgcagagtcc
     6601 gatcttgaag gaggtgctag cacgatagag aagagtaggg ttgtgctgtg ggcctttatg
     6661 tgtatatgat agactgtctg acgattcgtc tgtgtttctt gttaccttgt agtagttggt
     6721 tgctgtctac ttctaccctt ttggaataca tttaccaatc actccaatta tcacagtaca
     6781 gtagaataac attcccgcgc tagctgctct cgatataaag atactactcg agtatgcttg
     6841 accgggtctt tgggttttgt agacatgttc gtgtctttat gaccctcgtc cccggtggtc
     6901 gcgttgtgca tcaatcttgg atccctttct cttttctacg cgcctctact gtgtctttat
     6961 attcttggtg ctcggtcggt tgtttattgc aagagataag aaaggaagtg gaattatatg
     7021 aaatactatt ccagttaagt tcaaactagt tcacttgcaa acaaccatag cagcagtact
     7081 agtaggtgtt tcctagtact ccattatata ttttggggca actcaggtat agtactcgta
     7141 ttacgtgtta tgttttttaa agtaggccaa acagcgtgtg catggaagaa ctcagtggct
     7201 ccttgcatct taatcggacg ggcttgaaaa gagatagggc ttcaatacca tatgttcaat
     7261 tgttggactt atggaggtac tacacgctgg gctcttcatt cagagggtct acttggagat
     7321 tgactgtaag tgtgtcaact acttgtaaca caagtattca ctccataata tataccagca
     7381 tcattggtct agtggtagaa ttcatcgttg ccatcgatga ggcccgtgtt cgattcacgg
     7441 atgatgcact cttctttttt cctctttcct ctttttcccc cccgctcttc cttcccagcc
     7501 atgtctattc gttcattcta ctatctattt ttgctatctc gtatctcctc tcctctgtct
     7561 gctgtcaatc cacctccaat catcgccagc cctcagactg ccgccctgca gctctcgggc
     7621 ctgccgatcg caacccaccg ctgcagttcc cccactccac ggctcatctt tagcagaagt
     7681 ttagacctgc ctatctgtct actttgtgtc ttttggatgg ctgtctggtt caacggttat
     7741 ccacagttga tcaagtgact ctgttgccag tggaacagct accctgcacc taactctttt
     7801 ctctctcttc agccacttgc cagccaacgg ggtcccttct gcctctgata ttggaggatg
     7861 acgctatcca tctcgcactt ctctcgctgg gtttcgctgg cagcttcaca ttggcccgtt
     7921 gaggttgaca tgactaacta cggttcaaag tagtgcaacg gctatcttct tagcttagga
     7981 tggatgctca gaacgaatca tcgggccggg attcgctggt gatcgggggt cagccgaggg
     8041 gagatatgac gagcttccct ggaagtgcca tcatcaacct tggtgggagg ggcaaaccag
     8101 aggaggaaac gacaaacgag taaggcaaag caaaggcaat gcaatgcaat gcgagaacca
     8161 aagcacagtc agtggattcc accttcacag agggagaaag agaacaaaac tcaccagagt
     8221 aaggcaatga tccgcaaacc aaggtccaat gggaaacccg acggagaatt aacaacgccc
     8281 ggttccaccg taaagatgtc aggttgattg ccttggaggg ggaccctctc tcgtctcctc
     8341 tctgtatctc ccagaacttg ttggaattac ccactgtgga aaaagtgatg ctatctcggg
     8401 acaatgagga ccctcctggc ccgagcgttt gcagcctgca gagattgtcg ctgggatcgc
     8461 tggcagaaac tctacttctc tcctacaata actttttctt cttttatctt ttcaatcatc
     8521 ttggagggga aactaaactt aaacatggga atagactttg gattgatgcc cagccacatt
     8581 actactcaag tttatgtagc cgagaaaatc ataatgtgac tggggatggg aggctaacga
     8641 gagagatcgc accatctgca ctcatggtat gactgaaccc tctccaagcg atggtaacga
     8701 gggcaaccac aaccgcccat ttgaacagtg actgtgccag tgtcagtgcc ctccagagtc
     8761 tttaccgcga tcgcgatggc gtcgattcca accaaattgt tatgctttct ccctctcggg
     8821 caggtggggc cgttgcgtaa ctcggaattc tgattgcatc gcgaaaccga aaatattccc
     8881 caagcaaaag gtgtgagtga gtgatggatc gatggcagtg gaagtgtaaa aagtagtgac
     8941 tatcaagaag ttgtcgatcc tgcggagtct atctcctctc ccagactact ttgtgtactc
     9001 cgtactactt ttttttttac tacgtatact tcctagtgct gcctgccata tcaacccctc
     9061 cctccgatca tcatcctttt tctgactaga tactgtagac ttgttgactg cctaatcaac
     9121 tgaaaacgag ctaactactc ggtagtctgc cttgatagtc tttcgtagtc ttctgcacca
     9181 ctccgatctc tgctcgccag ccaccgggac aggcgatatt tgcaaggcaa tttggcccct
     9241 ctacgaacct actttcgccc gacaagttga acatgaaaaa tcgaaagcaa aaaatattcg
     9301 cccccgcggc ggacagatga attctttcgc accttcggag acaaaacatc gtcatatctg
     9361 ctggtggaca tgcgttggcc caatgagaag gacagccagc agcgcgtcga ggatgaagcg
     9421 gtgaagggca cagcgatgga gatccacatc gggcaagccg tggaggtgaa gctaaaaacc
     9481 ctaacggcac taagaagacg cagaatgatc agaatcctcc atcccagcag ctaatggacc
     9541 cacgaactgc tgtagccgca agacagctgc cgttgtgtcg ccaatcagcg agctttcggc
     9601 cgcgtagctt gcatcccgtc cactcggcag cttctcaact cctccctctt cgtttgcttt
     9661 ttttcgctgc tactcactgc ttctcgggga ccaactggag gtccatgctg ttttcccttt
     9721 cgataaggat gtgaaaattt ttcttgttgg tcagaccatg acgccgacac caatctggag
     9781 gggtggacat ctttgcgcat gagccagcga tctcaaattg ctattaaaga ctccatctgg
     9841 ttcctcttct gctccctctt tctctcttcc ctttcttcct tttcaactta tccgcgtcga
     9901 tcgcgttgtg aaatattttt atattgtgac cgcattgctg gtcctgtatc actactctta
     9961 ttaccttttt ctttcaattg ttctgttgtg aatcatccca atgttcaagc agtactccca
    10021 catcctgtcc cacaagaggc gtcgcagcag gggaagcacc atcaaccaag tcctgtcggg
    10081 cgctcagtcg gagcctgcat ccgaagcagc cactgtcagc gagcccgtcg aagtatggac
    10141 gcactcgcag gtgctgcccg aggatgatga gcatcgcaag gactgcttca ccaccctgac
    10201 cccgcgcatt cacaagtacg accatgtcgc ccagcgcggc agcgatcgct tcgtccagga
    10261 cctgacggca gcgctgaacc tggatgagcc ccagaccagc tacctttcct cccccgtcgg
    10321 caactatgcc agcttcctct acccagagtg tctgcccgaa cgtcttgaga ctgtcgctta
    10381 tttgacggaa ctgggcaatc tgcatgatgg tatgtgaaac cccattaatt accatcacca
    10441 tctcctggca tggctcggac ccaccactga cgtcttaggc aaacaacaag gcaagaaaac
    10501 cgatgaatcc gccgaatccc ccgtgtcgct gcccggaagc aactgctgga aaaggccatg
    10561 tcggagctgt cggacaagga caaggatggc cacgagatca tcgactgcta ccgcagtaac
    10621 tggctggtca ccccggaggt ccccacggcc gagaactgcg ccaacctcga cgactatgtc
    10681 gcccggagac gcctcaatgc gggcattgag taagtcacct tcacctcccc ccttgcatag
    10741 ccatacatat acaatggatt gctaacgtgg ataccagcgt ctactggacc ctcatgggct
    10801 tcgcgcacgg cactcgtctc ggaaaagagg accaggcggt ggtgcgcgac gcactggatg
    10861 ccgccgagcg caccatgttc ttcaccaacg actactacag ctggcccaag gagaagcgcg
    10921 tctccaagaa gaagcccgtc gccaacgtga ttctcttcct catggaacac cagaacatgt
    10981 ccgaggagga tgccgtcgcc aaggcgaagc agctgatcat cgacaacgag cacgagtttg
    11041 tccgccgtcg cgaggcgctc taccaggcca actcggacct ggcaccacag ctccgcaaat
    11101 ggatggaggt gctgggcgcc tccctggctg gtattcacta ctggtgtaag aatgctccgc
    11161 gctatgcggt ccccgaaacc gcagaggaga gtgaagagga ggagtcgtcc gaggaagatg
    11221 gctctgatga ggaagaatct tcctctgacg aagacaccga cgacgacgac gaggaagagg
    11281 aagaggaaga ggaagaaaag gctgcacccg ttgaggtggt gccggaaccc gaggagagtg
    11341 aggaacccgt ggaggtggct gtctggactc ccctggtcac cgaggaggaa acccccgacg
    11401 tgcatctgga tacctccgcc ctgctggccc cagcagctac gcccgctcga tttcccgcag
    11461 caccctgcac agtgatctgc tcacatctct gaatgcctgg ctgcaggtcc ccgcccgccc
    11521 gctggccttc attcgccagg ttatcaccga gctgcaggac tcgaccggca tgctggccga
    11581 cgtgcaggac caagccgcgc tgcgcgacca gcgcaccccg gcccacctgg tgtacggacc
    11641 cgcacagtgc atgaacagtg cggcgtacct gtttgtgcgc gccgcccgca ttgtcaccag
    11701 cctcaactgc cccggcatgc tggacgggct gctgcaggaa ctggaggcgc actttgtcgg
    11761 ccagtcgtgg gagctgaact ggcgcttctc gacccactgc cccggcgaga ccgagtatct
    11821 ggccatggtg gaccagaagg ccggcgccag cttccgtctg ctgacgcgcc tcatgcaggc
    11881 ggccagcatg ggcggcgcga ccctggactt ggagcctttc accaaggtgc tgggtcgctt
    11941 gtcgcagatc cgccacgagt acctgggtct gctggagtcc gcggccagcg accgctcgtt
    12001 cggcgaggac ctggatcagg ccaaggtgac gtaccccatc gtgcgggcct gcaacctgga
    12061 ccctgctggc cgggcggtca tctttggcat cttccgccag aagccggcgg gcacggtcct
    12121 ccccatcgag agtaagcgcc agatcgtgtc gctggtgcaa cagaccgggg cgctgcaggc
    12181 cacctacgac ctgatccggc agctgggccg cgaggccatg aacacgctga gcgagctgga
    12241 gacggcggcg gaggagctga acccgtcgtt gcgcgcggtg gtgaagtctc tggttgaggt
    12301 gccggccccg gatcacctgt aaaaaaattt gatacctttg acggagacga tgcatggtgg
    12361 ttgatacgat gatgatgacg atgatgagga tgacactcct tgtttctcta atgtctacat
    12421 gtctattttc ctttggcgtt tttctgtgat gatgatttac gagactttcc ttgatgtacg
    12481 gctatgagat gatatgatta atgacgatta tattcaagta ttcgaacgac tgccttgtgt
    12541 aaacatgtag aaagaagagt cttattctca gtacacagta ttatcgctac aaacatcatg
    12601 aattacaacg caatcaacac cgacttcagc tcggtccagt agtctgtggc atatcgactc
    12661 agctctcgtc cctctccact gcccttccag cccccaaatg gcatgtcaaa cgccatggtt
    12721 ggactggtgc agttgactcc cacggtgccg gcctcgaact tcttggctgc ccgcagcgcc
    12781 cgcgagatat cccgcgtgta tatactggca tacagcccgt actcgctgtc gttggcgcgt
    12841 gccatcacgt cttcctcgtc ggtgaaggtg ttgacggcca ccacgggacc gaaaatctcc
    12901 tccttcatca agcgcgactc ctccggcaca tctttcagga tggtcggctg cacaaagtac
    12961 cctttgtcgc cctcgcgctc accgcccaag tacaccgaga caccttcttg cttcgccagg
    13021 tccaggtagc cctgcacgcg cgcaaactgg gcggcatcgg cctgcgggcc gcgcgtggta
    13081 cccgggatga gagggtggcc actcttgccc atctccgtca tggtggtctt gagctgctcg
    13141 aggaactgag gggcaatagc ctcgtgcacg tagacccgcg agctggcaac gcagacctgg
    13201 ccggaattgg tgaggatgga catggcggcg gccggcacgg ccttgctcag atcggcatca
    13261 tcccagatca ccagcgggga cttgccgccc agctcgaggg tgacgctctt gaggttcgat
    13321 tcggcagcca tcttctggat ggcgcgaccc gtggcggtcg agccggtgaa ggagatcttg
    13381 cggatctcca tgtgacgggc aatggcctcg ccgcaagggc gaccaaagcc gctaagcatg
    13441 ttgaagacgc ccgggggatg cctgcttcct gagcacagcg agcagccacc aggcaactca
    13501 gaggggcctt ttcggaggac ttgatgacga tggtgttgcc ggtgactaag gccgcggcag
    13561 ccttaaagat catggtcacg acggggccat tccaggggac aatggcacca caaacgccaa
    13621 agggttggcg caagctgaca ttgacgaagc cgggagtatt caaggaggat tcgccagtga
    13681 tatcaagggc cttggcagca tagaccctca cgaagagggg catgatgcgg ccgacgtctg
    13741 ggttttggtc atgagttaga catgtctgtc tgataggaat gacgagggaa tgagcttact
    13801 gtcactgtaa gcgggtttgc ccatgcaaat ggcatcaagg taggccatct catcggcgca
    13861 tgcctccaga cgatcggccc atttctccag taactgggcc cgctgcaggg ctcccgtttc
    13921 cgaccaggct gggaaggcgg ctttggcggc tgcaacggcg cgatcaacat cctcgggacc
    13981 ggcttcgtag accgaggcac tcagctcctc ggtggcaggg ttgtacagat caaacttgga
    14041 ccccgagagg gaggggacaa actcgccgtt gatgaagagg cgagtctcaa tgttctcccg
    14101 ctggccggga tgttggggga tggattgaga catgatgata acaactcaat aaagtgaatg
    14161 aagaggaaat agatgtgagt attgacaggt aggagagcaa gagggccatg atgaccgggt
    14221 taatatacga aaattaaagg atattaggcc aaccgcagca atgaggggtt atgatggctc
    14281 ggcctctgca ctaatgcact ggtgtaaccg attcctccta tgagagtccc aaagcaaatt
    14341 cgtatccctg aaagatcgtc atccgtggct ccatgatcga ggagctctga cattccagat
    14401 gtttttggat gctgtcatgg gatgagagtt gcttgccgtt ctttgagaca gctcgacagg
    14461 ggagagagcc tgctgctgac tgccgtggag tcactagtca ctagctattc cgcatgcggg
    14521 atagagtttc aagcacacga agatctcgcc cccaagctac taatagctac tatggtacat
    14581 tatgctgacg gtctggatgt atggcctggc tcgtctcaag tggggcgctg agagctgaag
    14641 tatgaagtga gttgttcgat ggaaatgata tattagtaac tactaatagc catcccttga
    14701 tgtgggactg agacgcagac tatattgcga tgtccttcat tgttcagagg gagcacaaaa
    14761 gtcctggatg gttgcacaat tcagtcggta tgattgcctc ctggcatgag tggttgaatg
    14821 attccttgcg acagcgtcat caccatggtt gttgaatgtc atcctgtcat cccctcgagt
    14881 ggcggagata gggacggata tcggagttat cgtatccggg gatgatggtg gttgtctcga
    14941 cctgttccat caggctataa tattggtagt aagatgaaga tgatgaggtg taaatgctgc
    15001 agtcagaaaa aaaggaatgt gactagccat ctttgtttct ttatgccagc attgccgatg
    15061 attctggtta tataattatg ttggcctgtc catcacggcg gaatttcccc cgagtggata
    15121 acaccttccc attccggaaa tatgtcccgt ctagacaaac agtgcaaatg taacatacag
    15181 tggttccaca aaaatacatg gtatttgcat tatggacaaa cagaacaagc cagataaacc
    15241 cgctcaatgc caataataac tatggaacga tcgaagggga atcgatgagg gaaagagagc
    15301 tacaaaagac ccccaatatc ccctgaataa agatgggaac ttctttcgag atgtatcttc
    15361 cactaaaatt gtcaaacatc tctgtcagtc atgactggct cactaccgtc agtcctgcag
    15421 accttactgg ctgattccca ctacttctcc ctgcagagat ccgtctgcca ccataaccac
    15481 caccgccagc atgacatcgc ctccatcgaa tccatggatt catgggccca gttccgtctc
    15541 atgaagcagc tgctctgtgt caggcatcct cgccagtctc ttccatcctc cttactccgg
    15601 gagattgatc aggtgttgct tgaggaacgt gccaatcgcc ttcttcttga cgctgcttcc
    15661 attccagctc ttccaactcc atcatcatca tcaaagcctc tccccgccac gctccatctg
    15721 tggcaaggag acattaccac gttggatggc gttactgcca tcaccaatgc ggccaacgag
    15781 cagatgctgg gatgtttcca gccggcccat cgatgcctgg acaatgtcat ccatgcccgg
    15841 gcaggtcccc gcttgcgcga agaatgtttc caccacatgg atcagggaca gcgcaccttg
    15901 cccgtcggcc acgcatgtgc caccaaagga tactgtcttc ctgcccccta tgtgattcac
    15961 accgtaggcc ctcagctgga cgcgggacag cctgtgccca ccgcgcacca acgtcaacag
    16021 ctgcggcaat gctatgaggc cgtcctggat gtcgcagaag ctctgcctgc atcggatcct
    16081 cggggcaagt ccattgctct ttgtggcatc tcgaccggac tgtttgcctt tcccgtggag
    16141 gaggctgcat ccattgccat tcaatccgtt ctcgactggc tgcggcacca tctgcacacc
    16201 tccatcacca acatcatctt caacaccttc accgacaccg acacggccgt ctaccaacag
    16261 acactcaaaa aaatgcacta tccagttcct tccctagtgc cacctccccg ggtccatgga
    16321 tcctccctta tccaagccaa agcttggctg gctgctgccg ataccatttt gatcagctgc
    16381 ggagccggga tctcggcggc cactggactc gactatacct cgaccactct gttcgatcgc
    16441 cacttcccgg cattcaagca ataccagctg cgacggctgt atgatacctt tggccgcacc
    16501 aaccgtgact ggccatctga gagcgtccgc tggggatttt acttctccca tctggccatg
    16561 gtgcgtcgct ggccccgctc gtccctctat acctcgctgc taaaatggct ggcatcacgt
    16621 tttcaaccgg atcgggttca cgtgcggacc tccaatgcag acggactctt tgcagctcat
    16681 ggactgcccg aagcgcagct ctccacaccc cagggccagt atgccttcct tcaatgtctg
    16741 gaaaactgcc gtccggatgc tgtcttccca tcggcaccgt atcttgacgc tgccctgccg
    16801 catctggatc cacagacaca ggtcgtaacg gcgcaggaca aaatcccaac atgttcattc
    16861 tgtggtggcg ccatgtcgat ctgtgttcgg gcgggagact ggttcaacga acgacccttc
    16921 gctcccggcg aaacgcgatg gcaccaattc cgcgaggcct ttctcacgga tctgacacga
    16981 aacgtagtta ttattgagct gggtgtcggc ctttccacgc caggggtgct gcggtgggag
    17041 aatgaggagc tgatcgagca gggcgatgga cgcgtacggc tggtgcgcgc gggtttgggc
    17101 gatgccgtgc aggtccctgg ggagctggct gctgcgcagc tggccaccag catcgaaggg
    17161 gacttgcagg atgtggttcg ggcgatagtg gctccgtaga ctggccaagt gacatgtaga
    17221 tgtgatacat ctaatttgct aaagcgattc tttgctggac tttgctgttt cttcctgaca
    17281 tggtctatat atttctccgg gtacggtagt ccatcagcta cacatgcgta taactaccaa
    17341 agcagttttc tgtcctgcgc gatggccttc catcgaatgg aattgtgacc attccgtgaa
    17401 atagccagga ggatgtgatc caagtcgggt tagtcccgtc gttctctccg caccaggcaa
    17461 tgtggctgtc gaagatcggc ttttggcgca aatttccgag cggcaattat tgaaactagt
    17521 tcggcgggtc accaccaagt ttggccttca gaaatagaca cgcaaatggc agcgtgtcag
    17581 actgcaataa atcaacggca cccataaacc cctgtatctg caggatcctc aattattgat
    17641 atcttcttat gtagacacac atcatgtagg gtaattgaaa gactgagtta gtgatgagaa
    17701 ctcggtggta atctggaatg gcgccggtat aaaatcatgc atggcatccg tacaatcacc
    17761 cccgtcatcc gggcagagtg tgctgacctc aatacctcgg cgcgccatgc ctcgctacaa
    17821 ctggtggtat tctccgcttg tcctgggcgt gatatatagc gccttggtag gcgcagtttc
    17881 ccaacatccc ccagagaggt tcacagacat gtcctgaatt ttcaggtgcc gagcctggtc
    17941 accgcagact ccctgcacaa cgttcatctg gactttctgg acagtagctt tgaaggtcat
    18001 atcaatctgt tctacgggga ctgccatacc ggccaggggc atcatgagat cggccacatt
    18061 gtcatcgagc gtgacgctca tccagagcgc ttcgtctgga tcacacccgc cgatgcgcct
    18121 catctgcact gcctccacgc catttctgga tcgactctgc tcgctcgttc cgatcccatt
    18181 ccaattgcca cccgcttggc tcgtcgggaa agcatcgccg acgtggctga tgtgatgggc
    18241 ccctggtttg acggcgtcgc gtacatgcaa ggcaaggaac ccggaaaggc tgtggtgtcg
    18301 gcagcaaaga actcttccgt ggctattatc ggcggtggca tctccggaat gatgacaagt
    18361 ctgctgctca actctgtcgg catgaccaat tggcacattg tggagtcatc ccatcgacta
    18421 ggtggccgca ttcgcactca ctatctgaac gattcgcggc ccgatcagta ccaataccag
    18481 gagttggggc tatgcgcctt cccatgaaca tcacctacgc cgataccaac gagacactcc
    18541 agatccagga catgcgacta gtccttcagt tggccgatgt cctcaatgag ctcaacgccg
    18601 acgctgatcc agcgctgcga gtcaacttca ttcctttcat ccaggataat ccgaatcttc
    18661 cgactgacac gggaggtgtt cgtctgccag acggccgaat ccctactgta gcccaggttg
    18721 ccgccaactc gtcgctggca tacacggcgc ctcccgacaa cgccagtgcc gttgcggacg
    18781 ccaaagctca gtacatgcag tacgcccaga cagacaagat gggtaagatc cgggaggttg
    18841 ctcgcaacat gtaccgcgca cacaaagcgg ctctggaaga cgggttctac cactggtcgg
    18901 aagccgcata tatgcggtac gcgctggggg agaacgcaga tgtcgtcgac tacgccgctg
    18961 gcacggccaa caatcccatt tgggatggat tctacgatag tgtctacttt gcggccacca
    19021 cctggtttac catcgaccag gggatggagt ctctggtgcg agcattccta ccgcacgtcg
    19081 cagacaaagc caccctcggg cggaaagtgg acgggctctc gtacaacgag agttcgggca
    19141 agattgccta cacctggcgc gactctccgg tccaaatcac ccccgagcgc agcgaagaat
    19201 atgactatgc tgtcgtggcc gcgcctttca ccaaggtgcg catgtgggaa ttgccgcgat
    19261 attcgtcgat cctgagccgg gccatctccg agacaaacta tgaacccgcc tgtaagctcg
    19321 ccctgctgta taaaacccgc ttctgggagt accaggaaca gcccatcttc gggggctgcg
    19381 gcactgtgga cattccgggg gtgcaatatg tatgctatcc atcgttcaat ctgaatggta
    19441 ccggcccggc ggcggttctt ggggcatatt cccatggaag cccggcgcgg agtgtacagg
    19501 cgttgaaact cgaggattgg gtcgcattgg cacggcgcag catggtggag attcacgggg
    19561 cgattgcaga ggaacaattc acaggtaggc cggatccttt gaataagtag ccctcagtct
    19621 catgcttact gtcccgatag gtatctccca tggtcactgc tgggagaatg atgaacacca
    19681 aaacggcgcc tggacacacc cccttgttgg gcagcaagag attttcctgc ccgcctacta
    19741 ccaaaccgag ttccagacca ttttcgttgg cgagcatacc acgtataccc atggctggat
    19801 cgccgcggct ctagactccg ccgtgcgcgg gactacccaa ctcttgctgg acctggggct
    19861 ggtggatgag gccaaggcga ttgtgcatga gtggatgggt cgatggattg aattgtaaga
    19921 tataccggag ctcagaagtg tacaatctca aaatacaata gattttttcg ttcacacttc
    19981 caggtaattt agattgtgtc tgggctagga ttatagcgaa tcgggggttc tcgggcagca
    20041 ccgaacagcc gacggtgcct ccgaagtgca cggtcatgcc ccgaaggagc agttgtagat
    20101 cccccacttt ccgaccgtca acgtagtaat ccacggcgtc ggtcacctag gaagccatta
    20161 gagaagatca gtagacttgt gttcgtagcg tctgttttgt atggttatga cagtcgtagt
    20221 cagatatgat tatagcaggt ctacgagtat acaatccagc gagtagtgta tcccgacgat
    20281 tctgtattcc gagaacacaa tgcagaacat ccaagtatct tgctgtataa catacaaatg
    20341 agagcgtcca tccttcccat tacggtcctc cagattgccc ccggtcgcgt gttcgttgct
    20401 ggctgatata ccgtctccac tgaacctaag ttagcatagc tgcatctccg aaaatcatca
    20461 gcaaaaggcg ggtaagtacc attggattgt agaagtagac gggaaccccc aacagcagaa
    20521 ctccacccac cacccccgcc agaattcccg tggctgccgg ataactatac ttggccacca
    20581 tgggattcaa accatagctg accccaaagc ctatgatgtt cttcgtcccc acgaccgtca
    20641 ccagcgccgg accaggattc ttctcccatg cctccgtggc aaacgatgtc gtgcggatga
    20701 gggtcgaaac gaaggctacc tgatagagcg tccagcccat gaaaggcccg ccccaagtcg
    20761 catcgccgct ggcggtgaat ccatataata gcagcgaggc tactgccaac agccctggga
    20821 aaatcaataa gaggagatga tgttcgggtt tatgaacccc cccggcgcgt cgggccaacc
    20881 aaacaatgac acggtcgccc aagatccccg cgtagagcat gccgcccagc cctccaaaga
    20941 cgccgcctaa gttgatgagg ccaatgctgg cggcacccca gccgtagttg tactgcaaga
    21001 ctgtgtcata ggtgagagag acaccgacgg acccgcctag gatgacagca gagagcagtg
    21061 tggcatagat gatgccgggc gagctgaagg tctcgagcat ctgccaccag gtgagcagga
    21121 cgtcgcgcag gggatgaggg cagaggcgtg gccaagcgct gagcatctgg cggtaggttt
    21181 tcttgggagg cgtgtcgccg tcgaggtcgg cgtaagagcg accctcttca ctagtgaggt
    21241 attcttgggt ttctgtggca gtcaggactc gggtcactcc atattgatcg gtgacgacgg
    21301 cgtggtcgcc cacgaagatt ggccgacgct ggaaccgcgt ctcaaagcag gcaaacacca
    21361 ccagcaccag tccgacggcg acggttataa caaacaccca gtagaaccag cgccagccta
    21421 gcgcagctac ttcatatgag ctagccagcg tcagaaggct cgtcacgatg ttctgagtgg
    21481 cccagtagat gccatagatg gtgccgcgct ggtgaatgaa ggttacctct gccaacatca
    21541 gagggagaag ctatggtagg ttagatcaac cacaaaaaag aaatacagct gtcgcaccga
    21601 ttccgtcgct cctgtagcga atcccaaaag gatgcgtagc ccaaaatgct gggcccagtt
    21661 ctgtgacaag gcacagccga tcaacgaccc cagcaggacg gtgttggcga tgagcatcac
    21721 cggtcgacgt ccgcagacaa gggctaacgg caggatgatg tagttccctg acactggtga
    21781 gttgctgacg gtagcagaac tggaaaagac accttaccaa ttccgacaaa tagtgagggg
    21841 aaagtcgaga gccaaacaac ctggttggtg ctgtgacctt ctgcgccgta catctgaaag
    21901 aaaacatcca gaacagagcc cagcccacca atgaccgaga gtgacatgat agctgagaga
    21961 atgagcttga actcaatagt caattggggg gaagggaact tacaaaacca acaacagcac
    22021 accacgatgc ctgtcttctc ccacagtgca aagttcaagg ggtcattggg atcgtcgctg
    22081 ggcaccggca gacgctggat gcgaccggcc tcgtccacca gcacctgatc aacatgctcg
    22141 atgcaatcga catcaatctt cttgtcggcc attctgccgg atactcctgc ttgaacaaca
    22201 aatgggtctc atcgcagcgc gcgacggagg gttttaagct cgccgcttgt gtccactccc
    22261 gaagagacta agcatatttt agagaatgcg gggaagatat ggggaatgct ggacacgaga
    22321 ag
//
