LOCUS       ch1                    15725 bp    DNA     linear   PLN 04-MAY-2020
DEFINITION  Aspergillus niger strain KJC3.
ACCESSION   ch1
VERSION     ch1
KEYWORDS    .
SOURCE      Aspergillus niger
  ORGANISM  Aspergillus niger
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Eurotiomycetes; Eurotiomycetidae; Eurotiales; Aspergillaceae;
            Aspergillus; Circumdati.
COMMENT     'Annotated using 1.7.1'.
            ##antiSMASH-Data-START##
            Version      :: 5.0.0
            Run date     :: 2020-11-03 01:23:18
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 1650218
            Orig. end    :: 1665943
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15725
                     /aStool="rule-based-clusters"
                     /contig_edge="False"
                     /core_location="join{[1655087:1655758](+),
                     [1655818:1657264](+), [1657313:1657404](+)}"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      join(4870..5540,5601..7046,7096..7186)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     cand_cluster    1..15725
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..15725
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="8"
                     /rules="(Terpene_synth or Terpene_synth_C or phytoene_synt
                     or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps
                     or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /tool="antismash"
     mRNA            join(1..800,880..1000)
                     /locus_tag="KJC3_000716"
                     /product="hypothetical protein"
     gene            1..1000
                     /locus_tag="KJC3_000716"
     CDS             join(1..800,880..1000)
                     /codon_start=1
                     /locus_tag="KJC3_000716"
                     /product="hypothetical protein"
                     /protein_id="ncbi_KJC3_000716-T1"
                     /transl_table=1
                     /translation="MHTSDPRVNKPLAIIRILRLVANRTAGILKNSSSQVPQVAQHAHA
                     TLTIPSTSADPTDTKELTLQNTLQNAGRRRSSSNTRPGSSSRRQSLASIHGHHDDSSPR
                     LKWDEANLYLTEQEKTAKMKIDEPKTPYAPRYDPAEDEDELAGEESLIDAQDIVVDELD
                     KTKKAPKKTVAEDDIPELELGEAEEYGGDAHMGDADRIVRERSLSNDSHRGGKHVVVGA
                     GELNGETESGGDTLMTAGEAEEKHRQFEQHRKKHYEMRNIKDLLAHPEDLEDEMDEDED
                     EGDSSSAAVPPPMPRIPERFLNGGK"
     mRNA            join(2719..3482,3600..4233)
                     /locus_tag="KJC3_000717"
                     /product="hypothetical protein"
     gene            2719..4233
                     /locus_tag="KJC3_000717"
     CDS             join(2719..3482,3600..4233)
                     /codon_start=1
                     /locus_tag="KJC3_000717"
                     /product="hypothetical protein"
                     /protein_id="ncbi_KJC3_000717-T1"
                     /transl_table=1
                     /translation="MADQPEKTAAAPAAPEAQPPTTATTTTEPAVSESQTQPEPQPEAE
                     QKVEQATTGEEASPAPAATEPPVTEPTPAPAQEAPEDKKEEAPKEETKETKAEESKEEQ
                     KAEEPAAEPKAEAAKEEEQKPAQPEYLAKNPALSQFFDRLSAILSSTGHNEMWGVTLKD
                     SSDVPTVNILIKFLRANEGNVKLAEEQLTKALQWRKEMNPLALTEGRYSAERYGGLGYV
                     TKYPEANGKETIVTWNVYGNVKSIDQTFGDVDGFIKWRVALMELAVKDLKLSEATTVID
                     YDGEDPYQMLQVHDYQNVSFLRLNPTIKAASKKTIEVFSMAYPELLREKFFVNVPAIMG
                     WMFAAMKVFLSKNTTRKFHPISNGANLAREFPSLKDKFPKTYGGNGATLEEDAFTVNLE
                     KAEPAPEAPKEEPKEESKQEQAEAPKEEVKEEAKEEAKTEQPAAEEPAKAEAAVTTQEA
                     PAAAEAK"
     mRNA            join(4870..5540,5601..7046,7096..7186)
                     /locus_tag="KJC3_000718"
                     /product="hypothetical protein"
     gene            4870..7186
                     /locus_tag="KJC3_000718"
     CDS             join(4870..5540,5601..7046,7096..7186)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: terpene_cyclase"
                     /gene_kind="biosynthetic"
                     /locus_tag="KJC3_000718"
                     /product="hypothetical protein"
                     /protein_id="ncbi_KJC3_000718-T1"
                     /sec_met_domain="terpene_cyclase (E-value: 3.7e-15,
                     bitscore: 52.5, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MSGSHIGPWRTPAQGHLTPDANGDLKTDYTRWRLRDDRGRQTWHY
                     LESDAENEQWPQSIADKYFLGLPTGLPELPKPQTPLQCAENGLEFFSKLQLEPGNWACE
                     YGGPMFLLPVLIITYYVTKTPIPPEYATEIKRYLFARQHPEDGGWGLHIEAHSSVFGTC
                     MNYVTLRLIGVSEDDPRMIKARGLLHQFGGAIYGPHWAKFSLAVLGVMDWECVNPVPPE
                     IWLLPDWVPFAPWRWWIHIRQVFLPMSYLWSKRFSHPLDPLTKQLRQELYTQPYDSIDF
                     AAHRNSIHKADNYYPKTWLLNTLNSLLVNIWNPYLRVPAIVRRAEEWTWELVRMEDENT
                     DYAGLGPVSNPFNMIVCYEHDGPDSYSVRRHRERLHDYMWMKDEGMLMNGTNGVQVWDT
                     AFITQSIVVAGFGDDPKWRPMLTKALEFLEDHQLRENVPDQEKCYRQHRKGAWPFSNKT
                     QGYTVSDCTAEGLRSTIQLQEMHNFPKLISEERLKDSVDCLLLMQNPTGGFTEYETTRA
                     SEKVEWLNAAEVFGGIMIGYDYPECTTASVTALSLFSKYYPNYRAAEIKSAKEKAVQYI
                     KRVQRADGSWYGSWGICFTYAAMFALESLASIGETYETSADSRRGCEFLISKQKEDGGW
                     GESYLSSEKHVYVQHEKSQVVQTAWASLALMEAGYPHKEPLRKAMQLLISRQQANGEWL
                     QESIEGVFNQSCMISYPNYKLYWPIRALGLYARKFGNEELV"
     mRNA            join(7599..8396,8452..9042)
                     /locus_tag="KJC3_000719"
                     /product="hypothetical protein"
     gene            7599..9042
                     /locus_tag="KJC3_000719"
     CDS             join(7599..8396,8452..9042)
                     /codon_start=1
                     /locus_tag="KJC3_000719"
                     /product="hypothetical protein"
                     /protein_id="ncbi_KJC3_000719-T1"
                     /transl_table=1
                     /translation="MNAASLGDTALQQSDPHTATIHYTTALLTHPRSPSYFIKRSTAFS
                     RLKPTPNLSAALRDAESAVLLARERGKRELIVEAQMRRAIVLFLMGRYVAAEGVVGVVE
                     GMIGLDKDGNGGEDKEEKVRKAMGGGAGKGIEAEVRIWGAKIRAKVNGLGEQSGERGEK
                     VEEVPVGVKVPGEKELRGQLEELRGGKVGEGIGGEEKQSQKVEDKVEEKGRAEVKETQQ
                     QQQQQQQQVKVRHEWYQSGETVVVTLYVKGVPKDKVAIELKEDSTSIQFPLPSGAEYDF
                     TLDPLFAPIDPSTSKVSVFSTKIDISLRKKTPGQKWSALESTTGPVISTPQPTVTPTTT
                     TTQAQAPSYPTSSRHGAKDWDKLASSLTQKPKKDKTKSSSKPKDEQGEGEEDDGEASDA
                     ESINSDFGGGDAVDGFFKKLYANADPDTRRAMVKSYVESQGTSLSTNWDEVGQGPVKVR
                     PPSE"
     mRNA            complement(join(9609..10710,10768..10823))
                     /locus_tag="KJC3_000720"
                     /product="hypothetical protein"
     gene            complement(9609..10823)
                     /locus_tag="KJC3_000720"
     CDS             complement(join(9609..10710,10768..10823))
                     /codon_start=1
                     /locus_tag="KJC3_000720"
                     /product="hypothetical protein"
                     /protein_id="ncbi_KJC3_000720-T1"
                     /transl_table=1
                     /translation="MFPAVTGNIDLEALSGICGSISIACWVVVFSPQIIENFRRGSADG
                     LSLLFLIVWLAGDVFNILGAVLQGVLPTMIILAVYYTLADVVLLAQCFYYRGFTLRDEP
                     SSPPRPVSPITAETYDEDTEIPSPVVPRKPTERTALLTSKQRSASYQAPLDTRSPASSA
                     TITPHHQPLLAHRRHSASSFLHTTVDGTHLSPVTPLVEPAKQPRPPRTLTLLQATFFNG
                     SAIILVCAAGILGWYISQTSSLSSDKNNNNKHKDSPDDLKMDTLGQVFGYLCAVLYLGS
                     RLPQILLNYRRKSTDGVSLLFFLFACIGNLTYVLSILAYSPVCERSHHGRCRSDELASL
                     YGRYILVNLSWLIGSFGTLLLDMCIFIQFFLYQDANGGEVDAEAR"
     mRNA            11258..12481
                     /locus_tag="KJC3_000721"
                     /product="hypothetical protein"
     gene            11258..12481
                     /locus_tag="KJC3_000721"
     CDS             11258..12481
                     /codon_start=1
                     /locus_tag="KJC3_000721"
                     /product="hypothetical protein"
                     /protein_id="ncbi_KJC3_000721-T1"
                     /transl_table=1
                     /translation="MINQRPSEPSLLEASTSINHVASMTAPAIRIPFTGPLPPPIIVPP
                     SARTVAGAIDALLAFLTAPPSPYLRGVGVGRHSQTVLLTGAGISVASGLSDYRGENGTY
                     ITNKTYRPIYYHEFVARHEFRKRYWARSFIGWPGLLKAKPNSTHWAIKDIGTKGYISSV
                     VTQNVDSFHSVAHPELPTLELHGYLRSAVCINCRTQVPRDEFQQSLERLNPAWAEFLKK
                     MVDIGALNADNPEEQRRRGLKINPDGDVDLPEAPYSTFRYPACPTCLEKPPRLQDGSQS
                     RVEVERDGAWLPSSTAGILKPAVIMFGENIDPAVRLGAEEAIDDAGRLLVLGSSLATYS
                     AWRLVERAYKRGMPIGIINIGGVRNESILFSKAEQETEAVCRHVRCSLPSQDILGPVAA
                     QLPSLTHH"
     mRNA            join(12847..13071,13154..13177,13245..14165)
                     /locus_tag="KJC3_000722"
                     /product="hypothetical protein"
     gene            12847..14165
                     /locus_tag="KJC3_000722"
     CDS             join(12847..13071,13154..13177,13245..14165)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs)
                     SMCOG1030:serine/threonine protein kinase (Score: 171.7;
                     E-value: 3.5e-52)"
                     /gene_kind="regulatory"
                     /locus_tag="KJC3_000722"
                     /product="hypothetical protein"
                     /protein_id="ncbi_KJC3_000722-T1"
                     /sec_met_domain="Pkinase (E-value: 3.3e-76, bitscore:
                     252.5, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MDMDGRDRSKSRTLQPPTADYLDLISNLASPKTFLFHPPRSTSRS
                     HPTPAAQSTTVAPSTTMDKQQPSSFQQLEKLGEGTYATVFKGRNRQTGELVALKEIHLD
                     SEEGTPSTAIREISLMKELKHESIVSLYDVIHTENKLMLVFEYMDKDLKKYMDTRADRG
                     QLDQATIMSFMHQLLKGIAFCHENRVLHRDLKPQNLLINKKGQLKLGDFGLARAFGIPV
                     NTFSNEVVTLWYRAPDVLLGSRTYNTSIDIWSAGCIMAELYTGRPLFPGTTNEDQLIKI
                     FRLMGTPSERSWPGISQLPEYKPNFHVYATQDLSLILPQIDPLGLDLLSRMLQLRPEMR
                     ISAQDALHHPWFRDLPQLQAQLQQQQQQQQQQQQMAGAYGGMVPPQQTY"
     mRNA            join(14953..15329,15431..15725)
                     /locus_tag="KJC3_000723"
                     /product="hypothetical protein"
     gene            14953..15725
                     /locus_tag="KJC3_000723"
     CDS             join(14953..15329,15431..15725)
                     /codon_start=1
                     /locus_tag="KJC3_000723"
                     /product="hypothetical protein"
                     /protein_id="ncbi_KJC3_000723-T1"
                     /transl_table=1
                     /translation="MSTEPNPSAQRPGASPSPPPPAPVPLTPGPRASKLQEIFDKALAR
                     TLRANSYANFSGCFPTPAKHVPASLESVWRQLNAKLEESAKAEFEDILAERDAVRQLNE
                     LDRLVGEAKVRKDRGVGGDSVAPHTLSPEELYKAHLLPHLMETQADLDAKINSVQNQNA
                     ELAEKVQAQRSEIESLLSGLEAVVADLEGAAAATTQFTSEHQLRQEAAQMDGEVKARSE
                     I"
ORIGIN
        1 atgcacacaa gcgacccaag ggtaaacaaa cctcttgcga tcatccgcat cctacgcctg
       61 gttgctaatc ggacagcagg tattctgaag aactccagct ctcaggtgcc ccaggtcgcg
      121 cagcatgctc acgctacttt gacgatccct tcaacctcgg ccgaccctac ggacaccaag
      181 gaacttacgc ttcagaacac cctccagaat gccggtcgac gtcggtcgtc atccaacact
      241 cgccccgggt cttcgtcgcg acgacagtct cttgccagca tccacggtca tcacgacgac
      301 tcgtcgcccc gcctgaagtg ggacgaggcc aacctgtatt tgacggagca ggagaagacg
      361 gccaagatga agatcgatga gcccaagacc ccctatgcgc cgcgctatga ccccgccgag
      421 gatgaggacg agctggcggg cgaggaaagt ctgattgatg cgcaggatat agtggtggac
      481 gaactggaca agacgaagaa ggcgcccaag aagacggtcg cagaggacga tattccggag
      541 ttggagctgg gagaggccga ggagtatggt ggtgatgcgc atatgggaga tgccgatcgg
      601 atcgtgcgcg aacgaagctt gagcaatgac tcacatcggg gcgggaagca cgttgtggtc
      661 ggggctggcg agctgaacgg cgaaaccgag tctggtggag atacgttgat gacggcgggc
      721 gaagccgagg aaaagcatcg ccagttcgag cagcatcgga agaagcacta tgagatgcgg
      781 aacatcaagg atctccttgc gtaagttgct cccctattcc caggatggct gtgggatttc
      841 tcatggaggt atggtatact gacgggcttt gttttccagc caccctgagg atctcgagga
      901 cgaaatggac gaagacgaag atgaggggga cagctcaagt gccgcggtgc cgcccccgat
      961 gcctaggatc ccggagcgat ttctaaatgg aggaaagtga gggagcgaaa ggaatggacg
     1021 gacgggacta agttatcact ctactcgaga aggattagga cgagaagagg tgataggaaa
     1081 ataggatgga gggagggact agttgattct tgctgcataa acggactctg tatattcccc
     1141 agcgttgttt agtcatgatg ggacggactt gtatgaatct atgggaagta ctttgctttt
     1201 tttttttttt ttttttcttc ttctctagtt gttcactctt cctgctagct gatgtggatt
     1261 gtgtcggctc ttttttttct ctcatagcga acgatgggtt gcttgatcga ttgatagacg
     1321 agagagatga aaatgaaatg tacggggagg ggagagagtt atggattatt gacacgtctt
     1381 gtttaaaaac tagatacgat gaagtaaatg agctagctgt cagggaaata acccacccga
     1441 agcagggaga gttctagact gtttgtctga ccacagcagg ccagggggga ctcgtcaccc
     1501 tcggggttat atgagtcgcg tcaaaaaata gaatcatcca atactctggg aagtactccg
     1561 taaaccgaat caaaccaaca tagaagataa aaaaaaaaaa agaaagaaaa aaaaaaaaat
     1621 agggaaccaa tgccattaga gaaggtgata agtagtcacc ttgagtccgc ggccagacta
     1681 ctctgagtaa tagtgagtta gagcacgcgc ctctccgcta agcccgaggc tgtcaaatca
     1741 tccgaccacc tgagacaaga agaataatta tagtatcaga atccaagagt cggcatctca
     1801 accaaccctc gagtcggtgc cttgcatgtc atctggagga agtgagtgga tgtgatcagt
     1861 caccgcatgc tgtaacctgt caggggcatt ctgggatttt tcttggtgag tctgtctgtc
     1921 ggtctctctc tctcctgaaa catccttgca ggcccactcc aagattcagg aggatgggat
     1981 ggatcatttt cggtttccta gtcgagttgc tattctgagt aacttggtta gttagttatt
     2041 ctactgtact acggagtact agctatgtac tctgtgtgtg tgtgtgcctt ccttcacttc
     2101 cactcaatgg atcagatgtt gaatcaagta taaggtttgt gctgggttct actattatct
     2161 agtagtgaag agtcatggta tatgactttt caaccatggg atggatccat attttaagtt
     2221 gtttgtttgg tctactctgg atctggtctg aaaccttcca gatgacagag aaatcgatag
     2281 ataaataaaa caaatcagtt agttgtcttg tctgatcgcc gttgaaacct cctaattgaa
     2341 attaacggcc gctgcagcaa ttaattaatt aatccactgc tatctctgat tggattgcgc
     2401 gcgttttctg tgctttctta gtttcgtctt tgcctgcttg tcgcttcgct tcgtttcttt
     2461 cgcgctttct gtcttttctg gtctctcgtg tttttcttct cttctcctct tcctcttttc
     2521 tcttcctctc tctctctctc tctctctctc tctctttttc tcccctgctg ttcatttcca
     2581 cggctgttat tggaaagcca tcccgctcgc gtccgatcgc atcacgcaat tccatacatt
     2641 cattttaatt cttatttccc ctctctctat ctttcactaa tctactgcta ccaaataata
     2701 catcccacta catccatcat ggccgatcag cccgaaaaga ccgccgccgc tcctgctgcc
     2761 cccgaggcgc aaccccccac caccgccact actactaccg agcctgcggt ttcggagtct
     2821 cagactcaac ctgaacctca gccagaagcc gaacaaaaag tcgagcaggc gacgacagga
     2881 gaagaagcat ctcctgcccc cgctgccacg gaacctcccg tgacggaacc cactcccgct
     2941 cccgcccagg aggcccccga ggataagaag gaggaagcac ccaaggaaga gaccaaggag
     3001 accaaggctg aggaatccaa ggaggagcag aaggccgaag agcccgcggc tgagcccaag
     3061 gccgaagcag caaaggagga ggaacaaaag cccgctcagc ccgagtatct ggccaagaac
     3121 ccggccctga gccagttctt cgatcgtctg tctgccattc tctcctccac tggccacaat
     3181 gagatgtggg gtgtcaccct caaggactcc tcggatgtcc ccaccgtcaa cattctcatc
     3241 aagttcctgc gcgccaacga gggtaatgtc aagctggccg aggagcagct gactaaggcc
     3301 ctgcaatggc gcaaggagat gaaccccctc gccctgaccg agggccgcta cagtgctgag
     3361 cgctatggtg gtctgggcta tgtcaccaag taccccgagg cgaatggcaa ggagaccatt
     3421 gttacttgga acgtctatgg taatgtcaag tctattgatc agacctttgg cgatgtagat
     3481 gggtaagtgc tgctgctgct gctgctgctg ctgttgctgc tgctattgct gctgctgttg
     3541 ctgctgctat tgctgctatt tcggaattaa aaagagggtt agatctaact gtcgcctagg
     3601 ttcatcaagt ggcgtgtcgc gctcatggag ctcgctgtca aggacttgaa gttgagtgag
     3661 gcgacgaccg tgatcgacta cgacggtgag gatccgtacc agatgctcca ggtccacgac
     3721 taccagaacg tcagcttcct ccggctgaac cccaccatca aggcggccag caagaagacc
     3781 atcgaggtgt tctccatggc ctaccccgag ctgctgcggg agaagttctt cgtcaacgtg
     3841 cctgccatca tgggctggat gttcgccgcc atgaaggtct tcctcagcaa gaacaccacc
     3901 cgcaagttcc accccatctc caacggtgcc aacctggccc gcgagttccc ttccctgaag
     3961 gacaagttcc ccaagaccta tggtggtaac ggcgcgaccc tggaggagga tgcgttcacg
     4021 gtcaacctcg agaaggccga gcctgccccg gaggctccca aggaggagcc taaggaggag
     4081 tccaagcagg agcaggccga ggctcccaag gaagaggtaa aggaggaggc caaggaggaa
     4141 gccaagacag agcagccggc ggccgaggag ccggccaagg cagaggctgc agtgacgacc
     4201 caggaggcgc ccgccgcagc ggaagccaaa taaaaagcta gcaagaggcg taattcacac
     4261 ctggtcggaa tgaggccagg atcacataat ttacggtaat ggatgggaca ggttggattg
     4321 atacccgggg gaatcggtag aatgattccg tgtcgttttg cgtacttgat acctctcgat
     4381 agtgtgtgct ttatatgttc tgggattgat gatggagtgc agaaacacta gatagtaata
     4441 tttaatgtaa caggtcatat agccgctgat ttaacgttac gatgtttctc tcgcgtcgac
     4501 cgttattcca tgcgttcctg catgcagcag taaactataa cactggattt cctgctctct
     4561 ttatgctgat ctccagccag gcacccctga tgactcagca gccagtgtcc ctcagtttcc
     4621 tgcaccaaca aaaacaccaa ctgcacagct gctgcacgaa caacaggcag caaataaaat
     4681 ccgggcaagg gagattagtg tgttgttctt cctttctctc ctctcgagtg tggttgtatc
     4741 ctataagcta tccctcccac tatccctctc tccactaatc tcaaccctgc cattccaccc
     4801 tttcaacccc cccccccccc cccccccctc ccccccaata ccataagtgt acaacaaccc
     4861 cccatcacaa tgtcgggatc tcacatcggc ccgtggagaa ctcccgccca aggccatctc
     4921 acccccgacg ccaacggcga tctcaaaact gactatacgc gctggcgcct ccgcgacgac
     4981 cgcggccgcc aaacctggca ctacctggaa tccgacgcag agaacgagca atggcctcaa
     5041 tccatcgcag ataagtactt cttgggtctc cccacgggac ttcccgagct ccccaaaccc
     5101 cagacgcctc tgcaatgcgc cgagaacggg ctggagttct tctccaagtt gcagctggag
     5161 ccgggaaatt gggcgtgcga gtatggcggg cccatgttct tgctgcctgt cttgattatc
     5221 acgtactatg ttactaagac gcctattccg ccggagtatg ccaccgagat taagcggtat
     5281 ttgtttgcta ggcagcatcc tgaggatggc ggctgggggt tgcatattga agctcacagt
     5341 tctgtgtttg gtacttgtat gaattatgtt acgttgaggt taatcggtgt gagcgaggat
     5401 gatcctagga tgatcaaggc cagggggttg ttgcatcaat ttggaggtgc catctatggg
     5461 ccccattggg cgaaattctc gctggctgtc ttgggtgtga tggattggga gtgtgtgaat
     5521 ccggtgccgc cggagatttg gtacgtttgt ttctatcatg tctagtgggt gatttgtgga
     5581 tgggatactg attcgaccag gctacttcct gactgggtgc cgtttgcgcc ctggcgctgg
     5641 tggattcata ttcgccaggt atttctgccc atgtcgtatc tgtggtctaa gaggttctcg
     5701 catcccttgg accctctcac caagcagctg cggcaggagc tgtataccca gccgtatgac
     5761 tcgattgact ttgcggcgca tcgcaactca attcacaagg cagacaatta ctaccccaag
     5821 acttggctgc tgaatacctt gaactctctg ctcgtcaaca tctggaaccc ctaccttcgt
     5881 gtccctgcca ttgtgcgtcg cgcggaggag tggacgtggg agttggtccg catggaggac
     5941 gagaataccg actacgctgg cctggggcct gtgagcaacc cgttcaacat gattgtgtgc
     6001 tacgaacatg acggtccgga cagctactcg gtccgtcgcc atcgcgaacg gctgcacgac
     6061 tacatgtgga tgaaggacga gggcatgctg atgaacggca ccaacggcgt ccaggtatgg
     6121 gatacggcct ttatcacgca gagtatcgtg gtggccgggt tcggcgatga cccgaaatgg
     6181 cggcccatgc tcaccaaggc actggagttc ctggaagacc atcagctgcg cgagaacgtg
     6241 ccggaccagg agaagtgcta ccgccagcac cgcaagggcg catggccatt cagcaacaag
     6301 acgcagggat acacggtcag cgactgcacc gccgagggac tgcgctcgac catccagctg
     6361 caggagatgc acaacttccc gaaactgatc tcggaggagc gattgaagga cagcgtcgac
     6421 tgcctgctcc tgatgcagaa ccccactggt gggttcaccg agtacgaaac cacgcgggca
     6481 tccgagaaag tcgagtggct caacgcagcc gaggtattcg gcggaatcat gatcggatac
     6541 gactatcccg agtgcacgac cgcgtccgtc accgcgctct ccctcttcag caaatactat
     6601 ccgaattacc gggccgcaga gatcaagtcc gccaaggaaa aggccgttca gtacatcaag
     6661 cgggtgcagc gcgccgatgg cagctggtac gggtcctggg gcatctgctt cacgtacgcg
     6721 gcgatgtttg ccctggagag tttggccagc atcggagaga cgtacgagac gagcgcggac
     6781 tcccgacgcg gatgcgagtt cctcatctcg aagcaaaagg aggacggcgg ctggggcgag
     6841 tcgtacctca gcagcgagaa gcacgtctat gtgcagcacg agaaatcgca ggtcgtgcag
     6901 acggcatggg ccagtctggc attgatggag gccgggtatc cgcataagga gccgctgcgg
     6961 aaagcaatgc agctgctgat ttcgcggcag caggccaatg gagagtggtt gcaggagtcg
     7021 attgagggag tgtttaacca atcttggtga gtatcatgat cgattgattg agagttctcc
     7081 actaacgagt gacagcatga tttcgtatcc caactataag ctgtactggc cgatccgggc
     7141 gttgggattg tatgcgcgca agtttggcaa tgaggagttg gtctgatctt ctatgaattg
     7201 ttcttctatg agtacatgta ttactactat actactataa ccttctacta attgataata
     7261 tgattcatgt atactatctt ctttatcgtt gatctggaga gtttagatgt gtagccaatc
     7321 acgtggatgc tccgctcccc gcatctctcc aaagaagatc atcgaacttg tttccattcc
     7381 attcacctct ccacttgtat tcctctttct cttacacatt atttcctttt ctcttcggag
     7441 attcccttac aaacaacaag actcattttt cacatctcgt actcagaccc atacttaaac
     7501 cctatctacc cacccaacaa acacaacaca acacagcaca acgcaacacc tccatccaaa
     7561 caccaccaca ctccaaccca ccacctcaaa acctcaaaat gaacgccgcc tccctcggcg
     7621 acaccgccct ccaacagtcc gacccccaca ccgcaacaat ccactacacg accgccctcc
     7681 tcacgcaccc ccgctcgccc agctacttca tcaaacgctc aacagccttc tcacgcctaa
     7741 agcccacacc gaacctctcc gccgccctcc gcgatgccga atccgccgtt cttctcgccc
     7801 gcgagcgggg gaaacgcgag ctgatcgtcg aggcgcagat gcggagagcc atcgttttgt
     7861 ttctcatggg gagatacgtt gctgcggagg gggtggtagg cgtggtggag ggtatgattg
     7921 gattggataa ggacggtaat ggtggggaag ataaggagga gaaggtgagg aaggcgatgg
     7981 ggggtggtgc tgggaagggt attgaggcgg aggtgaggat ttggggggcg aagattaggg
     8041 cgaaggtcaa cggtttgggc gagcagagtg gtgagcgtgg ggagaaggtg gaggaggttc
     8101 cggtgggggt taaagtgccg ggggagaagg agttgagggg acagttggag gagttgaggg
     8161 gagggaaggt tggtgagggt attggtggtg aagagaagca gagtcagaag gttgaggata
     8221 aggtggagga gaaggggaga gctgaggtca aggagactca gcagcagcaa caacagcagc
     8281 agcagcaggt caaggtccgt catgaatggt accagtccgg tgagacggtt gttgtgacgc
     8341 tttacgtgaa aggcgtgccc aaggataaag tggctattga gctgaaagag gactcggtat
     8401 gtattcactc cccttgactt aaacatgcaa gtcactaacc tatatacata gacatccatc
     8461 caattccccc tcccctccgg cgccgaatac gacttcactc tcgacccgct cttcgctccc
     8521 atcgacccct ccacctctaa agtctccgtc ttctccacaa agatcgacat ctccctgcgc
     8581 aagaaaactc ccggccagaa atggagcgcc ctggaatcta ccaccggacc tgtcatctct
     8641 actccccagc ccacggttac acccaccact accaccacac aagcccaagc cccatcatac
     8701 cccacctcct cccgccacgg cgccaaagac tgggacaagc tcgcctccag cctaacccag
     8761 aaaccgaaaa aggacaagac caagagcagc tcaaagccca aggatgaaca aggagaagga
     8821 gaagaagacg atggagaagc atccgacgcc gaatccatca actccgactt cggaggcggt
     8881 gatgccgtcg atggcttctt caagaaactc tatgccaatg cggacccgga tacccgccgc
     8941 gctatggtga agagttacgt ggagagtcag gggacgtcgc tgagtacgaa ttgggatgag
     9001 gttgggcagg ggccggttaa ggttaggccg cctagtgagt gattttcttt cttcttttct
     9061 ttctcagttt ctgagagaaa ggaaagaggg gagcaagaaa gaattgttgg ttgaaagatg
     9121 gagaagaagg gcgtatgcga attgcaagcg tggagttatg gtctacatcc atgttgtggg
     9181 tgcatgtggg tggtgtttta ggttctgaag ttgcttccct tgctagttac ttgttttgtg
     9241 tagcttagct tagctctgct ttacttgtgt aatggtaatc attgcaagat gtcgagactc
     9301 tgctattact taccttgtaa acatgatacg tagactacta catgatacac gtgatgtaga
     9361 agcaagtata gtataagata ataaataatt atatacacga aaagcaactc cgatccaatc
     9421 aaacgccaat cacatgagca agagtagcat agcaacctgg ccatatagca cgcaagcgtt
     9481 ttcagaataa atcattataa atcaagcaat ccctaagtac caaccccaac acctctttat
     9541 gtcttcccag aggcataatc aagaaaagag aataaacaag agagaaatgt aaaccacatg
     9601 cgaatatttt acctcgcctc tgcatccacc tcacccccat tcgcatcctg gtacaagaaa
     9661 aattgaataa agatacacat atccagcaat aacgtgccaa agctcccaat cagccaagac
     9721 agattgacca ggatatatcg accatacagc gatgccagtt catcagatcg acaccgacca
     9781 tgatgcgagc gttcacacac aggcgaatac gccaagatgg aaaggacgta ggtcaaattg
     9841 ccgatacagg cgaagaggaa gaagagcagg gaaacaccgt ctgttgactt gcggcgataa
     9901 ttgaggagga tctgtgggag gcgggaaccg aggtacagga ctgcgcagag gtagccgaaa
     9961 acttggccta gtgtgtccat tttcaggtca tcagggctgt ctttatgctt gttgttgtta
    10021 ttcttgtccg atgagagtga tgacgtttgg ctgatgtacc agcccaggat gccggcggca
    10081 cagacgagga tgatggccga accgttgaag aaggtggctt ggagcagtgt tagggttcga
    10141 gggggacggg gttgcttggc tggttcgacg agtggagtca ctggggagag gtgagttccg
    10201 tcgacggtcg tatgaagaaa tgaagaggcg gagtgacggc gatgggcgag caagggctgg
    10261 tggtgaggag tgatggtagc cgatgatgct gggctacgag tgtccaaagg agcctggtaa
    10321 gaggcactgc gttgtttgga ggtaagcaac gcggtgcgct ctgtgggctt ccgaggcacg
    10381 acaggggagg gaatctcagt gtcctcgtcg taagtttctg ccgtgatggg agagacaggc
    10441 cgcggcggcg aggatggttc gtcgcgcagt gtgaatcccc gatagtagaa gcattgtgct
    10501 aagagcacca catcggctaa agtgtagtac accgcgagaa ttatcatggt tggcaggacg
    10561 ccctgcagga cggcaccgag gatgttgaac acatcgccgg caagccagac gatgaggaaa
    10621 agaagcgaaa ggccatcagc tgagccgcga cgaaaatttt caatgatctg tggggagaag
    10681 accaccaccc agcacgcaat cgagatggat ctatcagtga tcagtattga acatgtccaa
    10741 ttctagcata ctctggcata aacataccca catatgccac tcagtgcctc tagatctata
    10801 ttgccggtga ctgcgggaaa catgtccggg cggtgcgaac gagagagcga ttgggcgttt
    10861 tcccaatcaa tgctctactc tataatctaa acaggaagag gctagcaaaa ctggtcgaca
    10921 gcaaacaaag acgcgttgat ggaatgaagc agatggccgg cgatgacgtt cgcagagtct
    10981 gcgaagggtg cagatcacgt gggacgatcc ggggtagctc ctctcagtct agaccaagaa
    11041 tggacaccca gatcgacttg cttccacttt tacttctttt ggctggggac gctttgttcc
    11101 ttgtcggccg caatgctctg tatcgtacat tctgggcctt ctggtcatct attactatct
    11161 gatcaagtaa tacttggccc cgtgtagtct gaccatccat ttcacactca atgggactgt
    11221 gtacatcatg tgaccgatta gtcaagccgt gacgtcgatg atcaaccagc gcccatctga
    11281 acccagcctt ctcgaagctt caacatccat caatcatgtg gcttcaatga ctgctccagc
    11341 aattcggatt ccctttacgg gccctctgcc tccgccgatt attgtccctc cgtccgctcg
    11401 cacggtcgca ggtgccattg atgcgctttt agcctttttg acggccccac cgtcgccgta
    11461 cctgcgcggc gttggtgtag gcaggcattc ccagacagtg ctcttgacag gcgctggtat
    11521 ctcggtagct tcaggcctgt ccgattatcg gggtgagaat ggcacgtaca tcacaaataa
    11581 gacgtatcgg ccgatctact accacgagtt cgtcgctcgc catgagttcc gcaagcgata
    11641 ctgggcgcga agcttcattg ggtggccggg gctcctaaag gcaaagccaa attcgacgca
    11701 ctgggctatc aaagacattg gtacgaaagg ctatattagt tcagtggtga cgcaaaatgt
    11761 cgactccttc cattctgtcg cgcatccaga actacccaca ctcgaactcc acggctactt
    11821 gcgttctgcc gtctgcatca attgtcgaac tcaagtcccg cgagacgagt tccagcaatc
    11881 gctcgagcgg ctgaaccccg cctgggcaga gttcctcaag aaaatggtcg atattggcgc
    11941 gctgaacgca gacaaccctg aggagcagag acggaggggc ttgaaaatca acccggatgg
    12001 cgatgtagat ttaccggagg ccccttattc gacctttcgg tatccagcat gtccgacgtg
    12061 cttggagaag ccaccccgat tgcaggatgg gtcccaatcc cgtgtggagg tagagcgcga
    12121 tggggcttgg cttccaagtt ctacggcggg aattctgaag ccggcggtca ttatgtttgg
    12181 agagaatatc gacccagctg tcaggctggg tgcagaagag gccatcgatg atgcgggcag
    12241 gctccttgtc ctgggcagca gtctcgccac atactcggcg tggcgcctag tggaaagggc
    12301 ctataaacga gggatgccga ttggcatcat caacatagga ggtgtccgga acgagtcgat
    12361 cctctttagc aaggcggaac aagagacgga ggctgtatgc cggcatgtcc gttgcagtct
    12421 cccgtcccag gatattctag gccctgtggc agcacaactg ccttcactta ctcatcatta
    12481 gggtccatgt atagattgaa aaaaaggatg tgatgtatag atggcggtga ggtgtatgaa
    12541 ccgcttacag ataagcatca tagtatatgt acaagcgata aaagttgaat ccaagcttgc
    12601 attattggag acgttactat tttcaaagta actgtatcca tcagatggaa tactctagaa
    12661 aagataatta taggcactcc agaatgattg gcaacggcga gctaagatag gcatgtaata
    12721 gacgccggga tagtggagac cagcaaagta ggagaaggcg agttacaaag tgatggcggg
    12781 ccagtcagcc gcccgtccgc tgttcgattc cagcgcgggg ctctgcattc gccggttcag
    12841 atcagcatgg acatggacgg tcgcgaccgc tcaaaaagca ggacattgca acctccaacc
    12901 gccgattatc tggatctcat ctctaacttg gcctctccca agacttttct ctttcatccc
    12961 ccacgctcca cctctcgttc tcatccaact cctgctgcgc agagtaccac cgtcgcacca
    13021 tcgaccacca tggacaagca gcagcccagc tcgttccagc agctggaaaa ggtgtgtttt
    13081 gatggcttcc ctactgtcta ccaagatatc acccatcaaa tgagagattt gtgatgctaa
    13141 ctgctgattc tagcttggag aaggcaccta tgccaccgta cgaacccctc cctccgcacg
    13201 gccgatcctc ttaaatcgca ctatgtactg acaccctctc gcaggtcttc aagggacgca
    13261 atcgccagac tggcgagctg gtcgccctga aagagatcca tctcgattct gaagagggaa
    13321 cgccatccac cgccattcga gaaatatcgt tgatgaagga gctgaagcac gagagcatcg
    13381 tgtcgctcta tgatgtgatt cacacggaga acaaactcat gctcgtcttt gagtacatgg
    13441 acaaggatct gaagaagtac atggataccc gcgccgaccg cggccagttg gaccaagcca
    13501 caatcatgtc attcatgcac cagcttctca agggcattgc gttttgccat gagaaccgcg
    13561 tcctccaccg cgatctgaag cctcaaaacc tcctcatcaa caagaaggga caacttaaac
    13621 ttggagattt cggtctagcc cgcgcctttg gcattcccgt caatactttc tccaacgaag
    13681 tcgtgacctt gtggtaccgt gccccagatg tgcttctggg cagccgcaca tacaacacga
    13741 gcatcgacat ctggtctgct ggatgtatca tggcggaact ctacactggc cgtcctctgt
    13801 tccctggcac caccaacgaa gaccagctta tcaagatctt ccgcctgatg ggaacccctt
    13861 cggaacgctc atggcccggc atctcccagc tcccggagta caagccaaac ttccacgtat
    13921 atgcgacgca ggatctcagt ctcattctcc cccagattga ccccctaggt ctggatctct
    13981 tgagccggat gctccagctc cggccagaga tgcggatcag tgcccaggac gccctgcatc
    14041 acccctggtt ccgcgatctc ccgcaattgc aggcccaatt gcagcaacag cagcagcagc
    14101 agcaacaaca acaacaaatg gctggggcgt atggtggcat ggttccccca cagcaaacat
    14161 attgagttct tcctttgatg cgtttctgtt ttccttatag ttcgttttca tcatgtacag
    14221 cctatcgttt accttgactt gcgttcatct gcttcctcgt ggaaggcttg acgagcaacg
    14281 gattcggttt tagaatgggg agcgcggcgt ttgactcctg agaggacatt cgaatgattc
    14341 ttgctgtttt ctgctttctt tgcgttgcat atggacccag agaaccgatg gcatctcgta
    14401 gataaacttg gccattatac ttatctattg ctctctatta ccttccatta tcgtagctta
    14461 ttacaagcgc agggacagca gcgacgatat cttgtcccgc agacaactaa atcaatcctg
    14521 acaagccttt atcagtgccg gatataagcc ctaacattcc acgcaaccaa gttgaacaca
    14581 gtagctaatc tcggctcgcc acgaaaagac aacttacaat aaggaccatc cttatatttt
    14641 tcaaactgat ttaaacacta caaatataca gtagcctaca catcttactt tataggtacc
    14701 taaactctgt aatatatgta ggtactccgg tcttctggcg ggatctatat ctatcacgtg
    14761 attaatagtc gcgcgcgtct tccggcgcgt cctccaatcc catcatcaat ctactattct
    14821 ccataatcct acaaccacga acaacaacaa cacaaaggag cttgaaacga acttaaggct
    14881 cagcataaca aatcactgca ccccaatcga aactcttcaa ccacctcaaa ccctcaaccg
    14941 gcgaaagaaa acatgtccac cgaacccaac ccatcagccc aaagaccagg cgcctccccc
    15001 tcaccacctc ctcccgcgcc ggtcccccta acaccaggcc cgcgcgcctc caaactacaa
    15061 gagattttcg acaaggcgct cgcgcgcacg ctgcgcgcga actcgtatgc gaatttcagc
    15121 gggtgttttc cgacgccggc gaaacatgtc ccggctagct tggagagcgt gtggagacag
    15181 ttgaatgcga agttggagga gagcgcgaag gccgagttcg aggatattct ggccgagagg
    15241 gatgctgtta ggcagttaaa tgagttggac cggttggttg gggaggcgaa ggttaggaag
    15301 gatagaggag tcggtgggga tagtgttgcg tatgtctccc cttccttatt cctttttttg
    15361 ctatttggca tcattacatt gggggcctgt ggatgatgga tggctaactg gaatgatttg
    15421 tgcttggtag gccgcatacg ttaagtccgg aggaattgta caaagcgcat ctgttgccgc
    15481 atctgatgga gacgcaggcg gatttggatg cgaagattaa ttcggtgcag aatcagaatg
    15541 cggagttggc tgagaaggtc caggcgcaga ggtctgagat tgaaagtttg ttgtcggggt
    15601 tggaggctgt ggttgctgat ttggagggtg ctgcagccgc gacgacgcag tttacgagtg
    15661 agcatcagct tcgacaggaa gctgcgcaga tggatggaga ggttaaggct agatctgaga
    15721 tctga
//
