LOCUS       ch8                    18250 bp    DNA     linear   PLN 04-MAY-2020
DEFINITION  Aspergillus niger strain KJC3.
ACCESSION   ch8
VERSION     ch8
KEYWORDS    .
SOURCE      Aspergillus niger
  ORGANISM  Aspergillus niger
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Eurotiomycetes; Eurotiomycetidae; Eurotiales; Aspergillaceae;
            Aspergillus; Circumdati.
COMMENT     'Annotated using 1.7.1'.
            ##antiSMASH-Data-START##
            Version      :: 5.0.0
            Run date     :: 2020-11-03 01:23:18
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 3141600
            Orig. end    :: 3159850
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..18250
                     /aStool="rule-based-clusters"
                     /contig_edge="False"
                     /core_location="join{[3151455:3151877](-),
                     [3150641:3151389](-)}"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(join(9042..9789,9856..10277))
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     cand_cluster    1..18250
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..18250
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="6"
                     /rules="(Terpene_synth or Terpene_synth_C or phytoene_synt
                     or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps
                     or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /tool="antismash"
     mRNA            join(1..159,265..1143)
                     /locus_tag="KJC3_012294"
                     /product="hypothetical protein"
     gene            1..1143
                     /locus_tag="KJC3_012294"
     CDS             join(1..159,265..1143)
                     /codon_start=1
                     /locus_tag="KJC3_012294"
                     /product="hypothetical protein"
                     /protein_id="ncbi_KJC3_012294-T1"
                     /transl_table=1
                     /translation="MTLTDYASYPDSPDLAALNLSRLVARLEHNLLSSAADLKPLRRSE
                     YQRMRVGANIEYARTNLQTLERTLPQIKPTDRRNDLQTDLARQRQILKQLQIVLDEISS
                     SQAEPQSDEEEEDDSLDGEDLLDTPEEGSTTDEQFEHEEKERDTITDDHEPATTAPTST
                     LPAPTTATTTTELPSQTPEATPAPTQEQPSTLRNRSHAPTTTPSTATASATGSSIQKNP
                     PSPQQSSDASSDARLQATEETLSSHRAEQENLTSSMLALATQLKTSAQTFHSSLEAEKS
                     VLARAVDGIDRTAGNMKVAEQRMGMLRRMTEGKGWWGRMMLYAWIFGMWVVAILIVFLG
                     PKLRF"
     mRNA            complement(join(2118..2161,2221..2777,2835..3177,
                     3253..3370))
                     /locus_tag="KJC3_012295"
                     /product="hypothetical protein"
     gene            complement(2118..3370)
                     /locus_tag="KJC3_012295"
     CDS             complement(join(2118..2161,2221..2777,2835..3177,
                     3253..3370))
                     /codon_start=1
                     /locus_tag="KJC3_012295"
                     /product="hypothetical protein"
                     /protein_id="ncbi_KJC3_012295-T1"
                     /transl_table=1
                     /translation="MGCGMSTEDKEGKARNEEIENQLKRDKMMQRNEIKMLLLGAGESG
                     KSTILKQMKLIHEGSYSRDERESFKEIIYSNTVQSMRVILEAMESLELPLEDARNEYHV
                     QTVFMQPAQIEGDNLPPEVGNAIGALWRDSGVQECFKRSREYQLNDSAKYYFDAIDRIA
                     QPDYLPTDQDVLRSRVKTTGITETTFIIGDLTYRMFDVGGQRSERKKWIHCFENVTTIL
                     FLVAISEYDQLLFEDETVNRMQEALTLFDSICNSRWFVKTSIILFLNKIDRFKEKLPVS
                     PMKNYFPDYEGGADYAAACDYILNRFVSLNQAEQKQIYTHFTCATDTTQIRFVMAAVND
                     IIIQENLRLCGLI"
     mRNA            join(7521..7557,7621..7721,7811..8061,8156..8570)
                     /locus_tag="KJC3_012296"
                     /product="hypothetical protein"
     gene            7521..8570
                     /locus_tag="KJC3_012296"
     CDS             join(7521..7557,7621..7721,7811..8061,8156..8570)
                     /codon_start=1
                     /locus_tag="KJC3_012296"
                     /product="hypothetical protein"
                     /protein_id="ncbi_KJC3_012296-T1"
                     /transl_table=1
                     /translation="MHEHEMSYMGPRAFSHDQSQDAEAEYDRLRNLARQEASKRNSCFQ
                     RSQEAYSSGDGAKAKELSEQGKAHGRKMEEYNKQASEFIFRENNANGRVAADTIDLHGQ
                     FVEEAEEILEERIKYAKAHGQDHLHVIVGKGNHSANHIQKIKPRVEQVCQELGLQYATE
                     ENAGRIYVNLTGGPADMETAPTPNHPHYQQYPQHQQHPSGTYAHPHQQQQQQYPGSQQQ
                     QQQQQQQQQQQQQQGAGNQDEIEQVVNAVLPKILNKLEKACCVVM"
     mRNA            complement(join(9042..9789,9856..10277))
                     /locus_tag="KJC3_012297"
                     /product="hypothetical protein"
     gene            complement(9042..10277)
                     /locus_tag="KJC3_012297"
     CDS             complement(join(9042..9789,9856..10277))
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: fung_ggpps"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: fung_ggpps2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182:Polyprenyl synthetase (Score: 239.4; E-value:
                     7.4e-73)"
                     /gene_kind="biosynthetic"
                     /locus_tag="KJC3_012297"
                     /product="hypothetical protein"
                     /protein_id="ncbi_KJC3_012297-T1"
                     /sec_met_domain="fung_ggpps (E-value: 1.8e-153, bitscore:
                     505.9, seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="fung_ggpps2 (E-value: 3.7e-97, bitscore:
                     321.0, seeds: 17, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MSAGPFPDFSASRSSQPGLYSLTGNSIDGKGGASLGKPDLLVSPA
                     MDHTGPDEDGLPTNTNHSRMHNRNRSSVDGTKYKDGQWSPDNERIVLGPYDYMLQHPGK
                     DIRRQLINAFNVWLKVPPESLSIITKVVAMLHTASLLIDDVEDNSILRRGIPVAHNIYG
                     TAQTINSANYVYFLALQEVQKLNNPAAIDIYVQELLNLHRGQGMDLFWRDTLTCPSEDE
                     YLEMVGNKTGGLFRLAVKLMQAESSSGKDCVSLVNVMGLIFQICDDYLNLSNTTYTKNK
                     GLCEDLTEGKFSFPIIHSIRSNPGNHQLLSILKQKTKDDEVKLYAVSYMESTGSFAHTR
                     DVVRELRAKALTLIQAIDGDQADGREDGAMVRAILNKITESTLGECGPQ"
     mRNA            join(11546..11801,11866..12500)
                     /locus_tag="KJC3_012298"
                     /product="hypothetical protein"
     gene            11546..12500
                     /locus_tag="KJC3_012298"
     CDS             join(11546..11801,11866..12500)
                     /codon_start=1
                     /locus_tag="KJC3_012298"
                     /product="hypothetical protein"
                     /protein_id="ncbi_KJC3_012298-T1"
                     /transl_table=1
                     /translation="MEALLAHSFDYLSSYEPSKVRKGLRQVEGLLAQICLSKTKRPSSD
                     KRRSLLSFGAPQPVPKSLAELRDDPAFREFFKLQEGFQWNVAMRLVTCLEHLLGRGSNG
                     TNDLLIVSTLDLIQGVLLLHPPSRTLFTREIYMNLLLDLLDPINCPAIQSATLLTLVTA
                     LLDHPANTRTFEELDGLLTVTSLFKQRATSREVKLKLVEFLYFYLMPETPMIPTSAASA
                     PNTAVLGHQRSPSKLGVSPVSRSVNVPGAHGGGKAHRDTRTTDEKQALLGRYLNNVEDL
                     VEDLKETAPFGATVY"
     mRNA            complement(join(13062..13345,13420..13625,13707..14037,
                     14139..14229,14291..14687,14753..14973))
                     /locus_tag="KJC3_012299"
                     /product="hypothetical protein"
     gene            complement(13062..14973)
                     /locus_tag="KJC3_012299"
     CDS             complement(join(13062..13345,13420..13625,13707..14037,
                     14139..14229,14291..14687,14753..14973))
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1138:FAD linked oxidase domain protein (Score: 218.9;
                     E-value: 3e-66)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="KJC3_012299"
                     /product="hypothetical protein"
                     /protein_id="ncbi_KJC3_012299-T1"
                     /transl_table=1
                     /translation="MAEVVAEIVANACHLEQEKATHIETLLSRFDSLSAAEQDQERASY
                     VAAVFPLFFGAAAVVHGSNGYEPQRIVPWSTNCWLQPRVIVRPGSAQQVAAALALCRFF
                     HVKFSIRGGGHLQIPGFTSNQDGVVISLGAFDQVRVAEDKSTAEIGVGLRWLEVYRALE
                     EHGVAVAGGRVPTVGVSGLLLGGGISFQNSQYGVGAMGVCNYEVVLANSQIINANAREN
                     SDLFWALKGGGPNFGIVTKIEMNTIPNQIWTEVRIYPLTAADQLRAALMQYHEAIETDN
                     RASLIWNATNDIILIVYFYCAPVENPPVFQAFYDIPFLTSFVPPGIRTVYDLVQAVASV
                     NEAEPTVHEFRTMSSRPSLEVYKAIEQAHAEQAEALKDVEGIALTTVIQPMSSLAMRET
                     LKNGGTPLGLEPVGQQWFLARADWKNIQDEDRVREAVRKIVDAAESAAKQTGVYLPYKY
                     SNYAAWDQDPLASYGGENVRRLKEVARKYDPEGVFQTLQNGGWLLSRVGLE"
     mRNA            join(15398..15511,15572..15637,15690..15794,15842..16220,
                     16269..16343,16393..16724)
                     /locus_tag="KJC3_012300"
                     /product="hypothetical protein"
     gene            15398..16724
                     /locus_tag="KJC3_012300"
     CDS             join(15398..15511,15572..15637,15690..15794,15842..16220,
                     16269..16343,16393..16724)
                     /codon_start=1
                     /locus_tag="KJC3_012300"
                     /product="hypothetical protein"
                     /protein_id="ncbi_KJC3_012300-T1"
                     /transl_table=1
                     /translation="MGGSIEQQDDVPTSSMTIAVRIIVLVLAIPTTLVCVLRLYLRKFV
                     LNNFGLDDWLVLVALIGVDLFSALAYIITYYGLGRPMKYVPTDHLVVFLTLEYASQCAY
                     LVIAATVKASLLIFIMRLFPTRFVHIAGKALLGIIAAFTLSGTLALVFQCRPVQAAYDK
                     AITNSSCYPTETSYAILMMQGVIMFVLDVSILVLPIWPIWQLQMPIRRRILVLGLLCIG
                     FTACVAALVRFSTLKFANDTTNFTYSASTSLIWMEIEFNLGLMSGSLPSLRKLFKLGSL
                     FPTSRSTKTQQSYTSDFELHRHSWTITGITKKTEIQRAYERSESQEFIAPIYGQGELTT
                     TTKAYADGETSSASNV"
     mRNA            complement(join(17203..17598,17674..17913,17993..18250))
                     /locus_tag="KJC3_012301"
                     /product="hypothetical protein"
     gene            complement(17203..18250)
                     /locus_tag="KJC3_012301"
     CDS             complement(join(17203..17598,17674..17913,17993..18250))
                     /codon_start=1
                     /locus_tag="KJC3_012301"
                     /product="hypothetical protein"
                     /protein_id="ncbi_KJC3_012301-T1"
                     /transl_table=1
                     /translation="MTPEYRDDPGQTPDNVSTVSRARDFFSVPTPIKRIFDRFPLVTYP
                     SNDLPHSAWSDKRGNRLYVFTDAASARHGRPSFNPQCLKWQAYLRFVGIDVDVIPSNNH
                     ASPSGALPFLIPAHPINNNAPIPSSKLQKWAIEQVHCEEEQQLDLRFEVYASLLDHRIR
                     NAWLYTLYLDPEEFEAVARPLYVNPSSTNSAVRTALALQLQQAARTEILKTSSYIDVGA
                     LEAEANDAFEALSTLLGDNQHFFDRPNPGLFDASVFAYTHLILEEKLGWRRNRLGQLLR
                     QHENLVQHRDRLLKFF"
ORIGIN
        1 atgactctca cagactacgc ctcatacccg gactctccgg atctcgctgc tttgaacctc
       61 tcgcgccttg ttgctcgttt agagcataat ctcctctctt cagccgcgga tctgaagcca
      121 ctacgccggt cagaatacca gcgcatgaga gtcggagcag tacgtcctcg cgcctttcct
      181 ttacccgaca ttatccatcg cgttgcatcg tggggaacac agctacagcc agcatcttga
      241 cttttgacta accttccacc aaagaacata gaatacgccc gcaccaacct ccaaaccctc
      301 gaacgcaccc ttccccagat caagcccacc gaccgtcgca atgacctgca gaccgacctc
      361 gcacgccaac ggcagatcct caaacagctc cagattgtcc tcgacgagat cagtagttcc
      421 caggcggaac ctcaatccga cgaagaagag gaagacgact ccctagacgg tgaagacctc
      481 ctcgataccc cagaggaggg aagcaccacc gacgaacaat tcgaacatga agagaaggag
      541 cgtgatacca taacggacga ccatgaacca gcaacaacag cacccaccag taccttaccc
      601 gcaccaacaa cagcaacaac aacgaccgaa ctaccttcac aaaccccaga agcaactccc
      661 gccccgacac aggaacaacc atcaactctc cgaaacagat cacatgcacc cactaccact
      721 ccctccactg caacagccag cgcaaccggc tcctctatcc agaagaaccc tccttcccca
      781 cagcaatcct cagacgcatc ctcagacgct cgattacaag cgacagaaga gacgctctcc
      841 tcccatcgcg cagaacaaga aaacttgaca tcatctatgc ttgcgctagc aacgcagctg
      901 aagacctcag cgcagacatt ccactcctcc ctggaggcgg agaagtcggt gctggctcgc
      961 gcggtggatg ggattgatcg cacggcgggg aatatgaagg ttgcggagca gcgtatgggg
     1021 atgttgcgga ggatgacgga ggggaagggc tggtggggac ggatgatgct gtatgcgtgg
     1081 atcttcggga tgtgggtggt ggctattctg atcgtgttct tggggccgaa gctgcggttc
     1141 tgattttgat gggaggcgta ggtgtcctcc atcggggagg gagtgccaag taacagtagt
     1201 agatagcact atccgctggg cggagattga agctgaacct gggtctagtc ctagacacct
     1261 tgtgtagata catgctgata attgataaac tattcctatc ttgtgcagat atttatttaa
     1321 cggatcaagc atttattcta aaagttcttc cattgtacac cgactctacg cggaaacacg
     1381 aattctttta acagaagata tatttcacaa tcctttaact ctgactataa cccaatgacc
     1441 gacccggcat gacacatgag aaaatgacat gaatatcagc gtaccctgtc aatctcccgt
     1501 gcccgtggcc ttgtcgtcgt tcattgccct ccaatgtacg tgagaccaat atggaagaat
     1561 gcgtgatata tggttacaca cagaattgcg gacgaggggc accaagagat gatgggatat
     1621 ccagctgggg aaaagaagac acaggataga aaaggaaaag cggaaagggg gggtggaggg
     1681 taacgcgaac acggagggag gtagaccaga aaacgacgcg ggaatcccat ataagtgaaa
     1741 agggaaaaag aagacacgca agcacgggct ctaattatct atgaattccg atggaaccac
     1801 agatgacccg ctgctcacag agaagagaaa cagaatggaa agtgcaaagg taaaacaact
     1861 cctgctctgt gtcatgggat ggatatcggt aatgctgata acaaagagcc ggctagatat
     1921 catttcaaga caaaggaaat agggaattag taaaatagac aagtgaatgt ctcaacgcca
     1981 ggatctctca aaagggagga aaaaaaagaa cagattgcga catggtatgg caaaaagcaa
     2041 aacagacaag attacaagtc acatagcata cggtctaaat gtcgagaagt tctcactcga
     2101 gcgaaatata ccggtcatta gatcagacca cacagtctca ggttttcttg gatgatgatg
     2161 tctagaggaa gtcagtatct ggaagcacgg aaccattcaa aaggggcatg caaaacatac
     2221 cgttaactgc ggccataacg aaacggatct gtgtggtatc cgtagcacat gtgaagtgag
     2281 tgtaaatctg cttctgctcg gcttggttga gagagacaaa gcggttgagg atgtagtcgc
     2341 aggcggcggc gtagtcagca ccaccctcgt agtcggggaa gtagttcttc atcgggctga
     2401 cgggcagctt ctccttgaaa cgatcgatct tgttcaggaa gagaatgatg gaagtcttga
     2461 caaaccaccg ggagttgcag atggagtcga acaaggtaag agcttcctgc atacggttga
     2521 cagtctcgtc ctcgaacaac agctggtcgt attcggagat ggcgaccagg aaaaggatgg
     2581 tagtgacgtt ctcgaagcag tggatccact tcttacgttc cgaacgctga ccaccaacgt
     2641 cgaacatacg gtaggtcaga tcgccgatga tgaaagtagt ctcggtgata ccggtggtct
     2701 tgacacgaga gcggaggaca tcctggtcgg tggggaggta atcgggctgc gcgatacggt
     2761 cgatggcatc gaagtagcta aggaatcggt taacaaaggc tcccgacgag cccgagacag
     2821 acgcgggcac ttactacttg gcggaatcgt tcagctggta ttcacgagac cgcttgaagc
     2881 actcctgcac accgctgtcg cgccacagag cgccaatggc attgccgacc tccgggggca
     2941 ggttgtcgcc ttcgatctga gcaggctgca tgaagacggt ctgcacgtgg tactcattgc
     3001 gagcatcctc cagaggcagc tccagcgact ccatagcctc caagatgacg cgcatagact
     3061 ggacggtgtt gctgtagatg atttccttga aggactcgcg ctcatcgcgg gagtagctgc
     3121 cctcatggat cagcttcatc tgcttgagga tggtcgattt tccggactct ccagcacctg
     3181 tttcaagaca tcgttagtct tgcgtcccag cgaaggcact gcgaaacatg cacggggaga
     3241 ggaggcgcat acccagcaac aacatcttga tctcgttccg ctgcatcatc ttgtcccgct
     3301 tgagctggtt ctcaatctcc tcgttgcggg ccttgccctc cttgtcttcg gtactcattc
     3361 cacaacccat tttggcggct attaatgaac gtgggagtga tggatgaaaa agtctaaatg
     3421 tgtagcgggg gtggaaaagg agtaggtggg cgggtggtag tgaacgtcaa gagtaacgag
     3481 cctgtccgca gggaaagatg tcagtcagcc atgggaagcg aattctccgt gtattgtaaa
     3541 attggatttc aaccagcccc ttgccccgtc gaccgtgggc gaacgcggaa agaaccacaa
     3601 tcggacaccc caagaaaaac aatcgaatga acgatgcacg atttgatttt tgagtgtcgg
     3661 aaaaggatca gaaccaaaag ccagcagtct ccccagagat cgtgctgacg caaggaggtg
     3721 cagctgatgc gtcaaccgga aggcttggga gcaccgttca ccatgaggga gggattccgg
     3781 ggcacagagg aagcgcaaag aggaaaagga acaacgacgt gaaaggggcc actcactttg
     3841 ctcgagaact tgatatatca aactccaact ggggaggagg agaaagagaa gaatggaatt
     3901 aaaccgggga tgatattatt actaaaggcc aagcggacgc aaaggaacgg gcggcagggg
     3961 aaaaatcaaa tataagcgcg gagcgtctgg gactagtagg cggaaaggag gcgaaaggaa
     4021 ggtggaacag cgaaatacac caatcgcggt gatttcagca aggataatcc agagaagttg
     4081 gatggaagag gatagcgaaa ggagaagtag taagtaaata atagagaaaa gaattggatg
     4141 aaaaagtaaa cccagggatt cttcggggag atgttggttc tatcccgatc cgtttgagaa
     4201 agttggggtt tgaaaggagg agaaggaaga agaagaggaa gagggagggg gtgggtggtg
     4261 ggaatagatg agacaagaga tcgaaaggga aaagaaaaga gagagagaga gagagagtaa
     4321 agcgagcgag gctgaagggc cggagggaaa ggattaagct caacaggttg taaggggggg
     4381 cagactttca gcgtgagtga gtcgggcaac ggaaaaagag gggccaagac gagatcctga
     4441 ggcagtcccg agagcgtgcc aaaaaagacg agtaagagag cgtgtgagag tgtgagggag
     4501 agagactacg acgaactagc ctggagagca gacagacccg ggaaaaggag ggactgattg
     4561 ggggaaaacc tgaggaagag gggattaact aaagagaacg cagcaggctg atacgccgac
     4621 tccatcacta ccgggtgccg gtacctgctg ctgctagtct actagtaaac taagtaggta
     4681 ttctagtacc aagtgagtat tggggggggg gggggtgtgg gtgaaggctg aggaaaaggt
     4741 ttttcctctt ctttttcgat ttcgattttg attttcccta ataaaatttt tataaaactt
     4801 ttttttttac ccttttcttt ttctcctcct tcttctttct gccattgacc attcccgctt
     4861 ttttctggaa cgataagctg acccggttcc aacctatgag tgacgataac tggaccactt
     4921 caataggggc agtggagtcg tctcgtttgg taaaggcgat ggcgacccag tctttggttt
     4981 ctgattggct ctgctggtaa ggggtggcag tggaggaaaa atccagcacg atccaatgga
     5041 attgcgattt taatgagtag ctctcccctt tttcgacgtc cggctcttct tctactttgt
     5101 accaagtttg tggtgctcca acttggattc ttctcccgat ggtaagacca gggcaattcg
     5161 aaaagggcat agcctcttac atcttaaatc cgaaaagccc atcctagaca cacctatgac
     5221 tattactacc acaccatcct ctactaactg gatactgcgt tatagatact gcatgtcggt
     5281 agcataaggc atgatccagc aaactatgag acatgaaaga ggttcaaagt taaatcccat
     5341 atagagtggc aatcttcttc caaagttgtc gttgccgtag atataatgat taatgattca
     5401 gttgcatgaa ttaatttccg gatgacgcag atctgcagtg cgcacctgta ggagatggcc
     5461 atggcgaccg ggatgccatt cgacagccca tcaggtgttg tttttaaact cttcaaatca
     5521 tgttaagcgc tgacctccac tggtgacgaa atcaatccca gatctctctt gtctctgctg
     5581 ctcatcagta acggactaga ctaatcctgc agcagtaata acaaccacag cagcagcagg
     5641 agccgcagaa gacatcgtca acagttcgta gtagccgacc gtttctaaac ctggtaaagg
     5701 gtgcaagctg gaagggcgcc tgcagtttca ggtgcccacc acgcggtgga ggcccggcac
     5761 gctcagcgcc cgatcgccag gtacaccgcg ccatcatggc tggcttttcc atcacacaaa
     5821 gttacgcggt cggttggctt gttccagaat gtcttggggg cttgagttgg aaaaagagac
     5881 agtgacgctt tactcgtagt gtctattcat agaccggaca ttctgaggaa tcaaacgtgg
     5941 cggtatcgtg catgtctgat gtgatgatat acggggtaga atgcaaccag cggaggctac
     6001 tactgcagct ctaccatgtg gaaaaggtgg atggcctcaa gattgggatg ggcattagcg
     6061 tacggaggaa tattgtcgtt cctgttccta cggccaggta ctgtatggta aaactccact
     6121 tgcaactgcc cgtcgatcgc ttctccgcac aaaagggaga aaaatggata gggagatgag
     6181 aatcatgcat tcacaaagac ccattcgctg ctcacccata tcttctgagt tctgatacac
     6241 gcttgtggtt tcgcccagtg gcaacatcga aatccaatat gtactccttc agtcgcatca
     6301 tctcatgctg tgacaacgtc tcccatggat aaaagaagga ttcagcgact tgtctcccac
     6361 aaccaccggg catgcacagg cggaacgacc cgcctgaatc gtgcaagatg gaatctgctc
     6421 agatattgct tgctggaatg gaggtcggta accgaaatcc gtggttctgc cactcgacta
     6481 gagaccaact tctccactgt ctagtcgcct ttagtcgctt gcttttaccg cccgcgctat
     6541 tcatgatgat tgtcgtctcc ttaccatcgc gtctttcccc ctcacccccc tttgacttgg
     6601 ggaagggcct cgtggcgagc tgcctgacat gtactctcct accactctgg gttatactaa
     6661 ttatgatgag taacttaagt tacatatccc ctggaggatc gcaactgctt ataatcgaga
     6721 actcctgccg ctgtcgaccg atagcctaag aaggcagctc ggactggact tatccccatc
     6781 ttcgcatgga gcatggccag actattgact tggtttccac tcttcactgg cttggtgacc
     6841 ttggcgtaga caccttatta tgtagacgct tttactgact cggttgtata gcctggaaga
     6901 agtgctgagt acggtcagtg ctgaacagga cttgatggag gtggctcagg ctgcagaaat
     6961 gccgaatggc aaaggattgg tggatgatgg tctggtctgc aggattgtaa gtaagcacgg
     7021 aaatgggctg acaggctttc taaagtctcc cagtccgttg caacccgtga tgggggtggc
     7081 tgaccgtgca tcctgtcaat acgaagaaag agattgagga agaccgtgca gagtaagaca
     7141 ctcaacccaa accgataact agactatcgc ctaccgcatg aagttatcta agaaagaagg
     7201 tgaccatgga tctccaatcc agcccagcct tttccctgtg cgattccatc cacgatccct
     7261 ggctggctca tcggccaatc cgatcgccgc tccactgatc catccacgga tccaattccc
     7321 gatccatctc ccagggactg caacatccac tcgcgcgatc ggccttcctt cgcagtcttc
     7381 gccttttgcg ctacactttt tttgcgatcg aggatatcgc atacagacga tacccgtagg
     7441 gatttgctgt ccgtcgcaga taaaccatcc cgttatcatt acatccggtt tcattcgata
     7501 gacacccctt attcgtcaaa atgcatgagc atgaaatgtc ctacatgggc cctcggggta
     7561 tgatcccttc ctaccttcat agccacaatc tcccataaac taacggcacc gataccgaag
     7621 ccttcagtca cgatcagagc caagatgcag aggctgaata tgaccgactc cgcaacctag
     7681 cccgacaaga agcttcaaag cgcaactcat gtttccaacg ggtacgccat taacaaccac
     7741 tgtcgcaacc acccaaccgc tcgccaaatt agagaaagaa acaaacaact aaccaatatt
     7801 taatggtcag tctcaagaag cctactccag cggcgatggc gccaaggcca aagaactctc
     7861 ggaacaaggc aaagcccacg gtcgcaagat ggaagaatac aacaagcaag cgtcggagtt
     7921 catcttccgc gagaacaacg ccaacgggcg tgttgcggca gacaccatcg atctgcacgg
     7981 acaattcgtc gaagaggctg aggagattct cgaggagagg attaaatatg cgaaagcgca
     8041 cggtcaggat catctccatg tgtaagcttc cctttcacgt tactctcaca cacactggct
     8101 tcttctttac cctcgacact gatcgctaat tgttacaatt ttccccaatc aatagaattg
     8161 tcggcaaggg caaccactcc gccaatcata tccagaaaat caagccccga gtagagcaag
     8221 tctgccagga actcggtctc cagtacgcga ctgaggagaa cgcagggcgc atttatgtga
     8281 atctgactgg tggaccggcg gatatggaga ctgcgccaac gcccaatcat cctcactatc
     8341 agcaataccc tcagcatcaa cagcatccgt cgggtaccta tgctcacccg catcagcagc
     8401 agcagcagca atatcccggt tcgcaacagc agcagcaaca gcagcagcag caacagcagc
     8461 agcagcaaca acagggtgcg ggcaaccagg atgagatcga gcaggtggtt aatgcggttc
     8521 tgcctaagat tctcaataag ctggagaagg cttgctgtgt ggtcatgtga aaaggatttg
     8581 agggacactg ggataaagat tttgtttggg caaaagagta ttttttggcc tatacatgat
     8641 atgatatgtg gttggtatag acaaagaagg gtgcgtgagc agacacgact gatcattgga
     8701 ctttcgcgca attgggcatt tggcggaaga ttacatatac cccgggctgt gtgttggatt
     8761 cagtatctag acggtgatta acatgttctg gtttcttatc tctcccggat tagaagagga
     8821 gaagctaaga agggaataag atcattgaag ttcgtattag agtcgccatg agtgcgcaat
     8881 gtttcagatt ataaggcatc tgatcaatag gctaaaatat atcacgtttc aacatcctgt
     8941 ataaaatacg agatcccatc caatcgacca accaaccaac cagggatggg cagcgaatta
     9001 tccccgagaa tgagtgcttg accatcgcct gtttgaatct actactgggg accacactcc
     9061 cccagtgtcg actcggtgat cttgttgagg atcgcccgaa ccatggcgcc gtcttcgcgt
     9121 ccatctgctt ggtcaccatc gatcgcttga attagggtca gtgctttggc tcgcaattct
     9181 cggaccacgt cccgcgtgtg cgcaaaactg ccagtgctct ccatgtaact gactgcatac
     9241 agtttgactt cgtcatcttt cgtcttttgc ttgagaatac tcaggagctg gtggtttccg
     9301 gggttggatc ggatactatg aatgatggga aaggagaact ttccctccgt gagatcttca
     9361 caaagacctt tgttcttggt gtacgtagtg ttggacaggt tgaggtagtc gtcgcagatt
     9421 tggaaaatca gccccatgac gttgacgagg ctcacgcagt cctttccgga gctactttca
     9481 gcctgcatca acttcactgc aagtcggaac aaacccccag ttttgttacc gaccatttcc
     9541 aaatactcgt cctcgctggg gcaagtcaga gtatctcgcc agaagagatc cattccttga
     9601 ccgcggtgta ggttcaataa ctcttggacg tagatgtcaa tcgcagcggg gttgttcaac
     9661 ttttgcacct cttgcagagc aaggaaatat acatagttcg cagagttgat ggtttgcgcg
     9721 gtgccgtata tgttatgagc tacgggaata ccgcgtcgca aaatagagtt atcctcgaca
     9781 tcatcgatcc tggctcatac gccataggtc aggtaggtgt ccagactaaa ccgaggcacg
     9841 atgaaaacag cttacagtaa cgatgcagta tgaagcatgg ccaccacctt tgtgatgatt
     9901 gagaggctct ccgggggtac cttcaaccat acgttgaaag cgttgataag ctgccgccgt
     9961 atgtctttgc cggggtgctg tagcatataa tcgtatggtc ccagaacgat tctctcatta
    10021 tctggcgacc attgtccatc cttgtatttg gttccatcga cgctggagcg attacgattg
    10081 tgcatgcgcg agtggttcgt gtttgttggg agcccatctt catccgggcc tgtgtgatcc
    10141 atggctgggc tcaccaggag atcaggcttt cctaggctag ctccgccctt gccgtcaatg
    10201 gaattgcctg tgagggaata taatccaggt tgagaagatc tgctagcaga gaaatctgga
    10261 aacggccctg cagacatggc ttgattgtta actgcttgcg tgttctacag gtgatcactg
    10321 gggtctcgtc gcgaacggag agagagggga gggggtcttc ggcgagcgga caatgctgta
    10381 acaaccaggc aaccgtgaga aaagggagga gtgagcaagc ccatcttaca ggtatcagga
    10441 atagggcgca gttgcactaa gtaagttcca cgccctgcga gaatgaagag aggagtaacc
    10501 ttaaaagggt ggattgcagg ctgcgtttgc ttttgctttc gctttcgctg cggggaactc
    10561 agccaagtga cgagggagca tcacatgcca atattgcttt ccccagctgg ggtcacatga
    10621 ctctgggtcg gcgaaactgg gaaactccga tccggtgaca ggctggaatg cctctcctca
    10681 cttcctcccc ttcccctctc tctctcaagt tacaccagat tcccctcctg tgtgattccg
    10741 tgtgacaagt gtgacgagtg tgacggaatt ttttttcaat tctactgtct gcaaggggtg
    10801 gtgacgtttg agtggttgca ccagccacga gcagcaggtt gtcgtgggca cggtcggtgg
    10861 gcctgtaaac attcagtcca aactatgctg gagactgttt ccgtgttggc tgttatactg
    10921 accgacttct tcaaggaact ctttgcaacc caacgggtga cggcatgata accctcaggc
    10981 ctttatcatg gccagggatt gacttagtgg cgtagctgaa aaatggatcc cctttcttga
    11041 catcattagc tgaaggctat caaggagatc ctgttcttca tggcgtctcc gtagcacgcc
    11101 tattggaaca cgatcgtgcg tctccgggac aaccatcggg tgtttttgtc ggatgtgggg
    11161 gagctgcagt cactaaggct gcccagtgac cgagtctaaa tcggctcgat cagcttctca
    11221 cgatgacaac aactatttct tcgctagttg atcgagccca ctgactatcg ctcaccaatc
    11281 actgtagcct ttaattaagg cccccatttt ccaagcgcct gggctcagcc gtgttcgatt
    11341 atttttctgg ctcctctctc ttaagttaag gtactacata tagatagcgc cgtatctctt
    11401 ggcccagggt cctttgcgat tgacagatca cggcccgtcc ttttcttttt cacccgtttc
    11461 ccttcacctg caacctagtt cctttttttc ccctgttaat tctggaaata gccgtgctac
    11521 tcatcacttc tgccttgtat tacccatgga ggctttgctg gcacactcgt tcgattacct
    11581 ttcctcttac gaaccaagca aagttcgcaa agggctgcgg caggtcgaag ggcttctcgc
    11641 acagatttgt ttatccaaga cgaaacgccc gtcgtctgac aaacggcggt cccttttgtc
    11701 ttttggggcc ccgcaaccgg tgcccaagtc tttggccgaa cttcgagatg acccggcctt
    11761 cagggaattt ttcaagctcc aagaggggtt tcaatggaat ggtaagtttc gctatccgca
    11821 gactcgcgat tatgtgagtt cccaacacta atgcactgca accagtcgca atgcgcttgg
    11881 tgacatgtct cgaacacctg cttgggcggg ggagcaatgg caccaatgac cttctcatcg
    11941 tctccacact cgatctgata cagggcgtgc tcctccttca ccctccatcg cgcacactat
    12001 tcacgcgcga aatctatatg aacctgctgc tggacctcct cgacccaatc aactgccccg
    12061 ccatccagtc tgcgaccctt ctcaccttgg tcacggctct tttggaccat cccgccaaca
    12121 cccgcacgtt cgaggagctt gacggactgc tcacggtgac ctcgcttttc aaacaacgtg
    12181 caacatcgcg tgaagtcaag ctcaaacttg tcgagtttct ctacttctac ttgatgccgg
    12241 aaacacccat gatccccacc agcgcggcca gtgcgcctaa cacggcagtc cttggacatc
    12301 aacggagtcc aagtaaactt ggtgtttccc cggtctcccg gagtgtaaat gttcccggcg
    12361 ctcacggcgg cggaaaggcg catcgggata cacgtacgac cgacgagaag caagcattgc
    12421 tgggccggta cttgaacaat gtggaggatt tggtcgagga tttgaaagaa acagcaccct
    12481 ttggagcaac agtttattag cggtgttacg agcgtcattg ggttctgaat ctctttgttt
    12541 atgttgagcg tgcatggata acggtatcat ggctggggtt ctctttcttc aatggtttct
    12601 tttttcttga tatcctcaag tttctttttt cctttgttcc tctatttcct ttgtctcttg
    12661 tttactcttc ttcagccttt cccgtctggt acggtctatg catccggcac aacagcctct
    12721 aacctatttc ttccctcatt ttttgtcaac gcttttccta tatgactcat gcatccgctt
    12781 gatgtctcat gtgtcacgtt gcgatcatgt ctttataatt ttatgcgacc ctgaatgaat
    12841 tgttatgaac gagaatggct tttttcccat tgagtagtgc catgcctggg ccgggccaat
    12901 gcatgtctta gacccgagct ccggcaacat ctcatccaaa ctttctgagc cacatcgctg
    12961 tggaaaccac aaatctcttg tacaatccca tatttactta ctgatgtata tgtacaatat
    13021 atcgcctacc tacatagctg tctatttgaa ggtctatgta gttattccaa cccaactcta
    13081 ctcaacaacc aacctccatt ctgcaaagtc tgaaagaccc cctcgggatc atacttcctc
    13141 gctacctcct tcaaccgtct cacgttctcc ccaccatagc tcgccaacgg atcctgatcc
    13201 cacgccgcat agttcgaata cttgtagggg agatacacgc ccgtttgctt tgccgcggat
    13261 tccgccgcat ccacgatttt gcgcactgcc tcgcgcacgc gatcctcatc ttgaatattc
    13321 ttccagtctg ctcgggcgag gaaccctgta ccacaagaat agatctatta gctaccagaa
    13381 ggaaacataa gacgtgttct cccttcgggg tatacgtaca ctgctgtcca acgggctcca
    13441 aacctagagg agttccgcca ttcttgagcg tttctctcat ggctagcgag gacatgggct
    13501 gaatgacggt tgttagggcg atgccttcta cgtccttgag agcttcggct tgctcagcat
    13561 gagcttgttc gatggctttg tagacttcta gactgggacg gctggacatg gtgcggaatt
    13621 cgtggctgca agagttcttt ggttagtttg tttctttgat atacttttca tgtttagaac
    13681 atgtaaaggg aggatatatg gcatacacag taggctcggc ttcattcacg gacgccacgg
    13741 cctgaactag atcgtaaacg gtgcggattc ccgggggtac gaagctagtg agaaaaggaa
    13801 tgtcatagaa ggcctggaag acgggaggat tctcgacggg cgcgcagtag aaatagacga
    13861 tgagaatgat gtcgtttgtg gcgttccaga tgagagatgc cctgttgtct gtttcaatgg
    13921 cctcgtggta ttgcattaga gcggcgcgca gttggtcagc tgccgtgagg gggtagatgc
    13981 gaacttcggt ccatatctgg ttggggatag tgttcatttc gatcttagtg acaattcctg
    14041 ggagatggtg gattagacat ttgatactga atagtaatac gaccgtaaat gctggtgttg
    14101 ctggtcatag attagggtga ttgtgggtgg tatagtaccg aagttgggcc cgccaccctt
    14161 gagggcccag aatagatcgg agttttcgcg ggcattggca tttatgatct gggaattggc
    14221 gagaacgacc tgttcagtga ttgttagctc ctgtgttctt catgggatga agcgaggaga
    14281 ttatactaac ttcgtagttg cagacaccca tggcaccgac gccatactga ctattctgga
    14341 aggagatgcc gccgccgagc aacaagccgg aaacccccac ggtaggcact cttcctcctg
    14401 caaccgccac tccgtgctct tcaagagcgc gatacacttc caaccatctc aatccgacgc
    14461 caatttctgc cgtggattta tcttcagcca cacggacttg gtcaaatgct ccgagggaaa
    14521 tgaccacgcc gtcctggttg ctggtgaagc ccggaatctg caaatggccc ccaccccgga
    14581 tggagaactt gacgtggaaa aagcggcaca gcgccagcgc agctgcaact tgttgggcag
    14641 atccgggacg gacaattacc cgaggttgaa gccagcagtt ggtagacctg gctcgattgt
    14701 ggtggttggt aaaggcattc ttttggtggt cgttccaaaa ctatagacgt accagggaac
    14761 tatacgctgc ggctcatagc cattggaccc gtgcacgacg gcagctgcgc caaagaacag
    14821 ggggaagacg gcagcaacgt aagaggcccg ttcctggtct tgttctgcag ctgacaggct
    14881 gtcaaatcgc gataagaggg tctctatatg cgtggccttc tcttgctcta gatggcaggc
    14941 gttggcgacg atctccgcga ctacctcagc cattgtgtga tctatgcacg agctatagat
    15001 gcaggtagtt gtcacacacc aaattttgag gaagtaaaag aaaagaaagg cgacgaagac
    15061 tgagaagaag gctcctgtta cttgaattcc gtgatccgaa tggtggatat cggctgggaa
    15121 ccgacaagac gctatctgcg ccggcgtctt gagcgatcct gcccccagga ttcaaacccc
    15181 tgtcaatgtt tgacaagcct cgaatttaga gcctgaaaat cctaagttcg tgtttcattt
    15241 gtacgttaaa ggtattggca tcatcgactt gcattccttc gtggtccaca gcaccccagc
    15301 caaatagtct agaaatgatg gctctccccg attttgcatt ctcttctctg tccatcctga
    15361 tgaccacctc tgctttggtg cgtgagagcc ggtcaggatg ggtgggtcta tcgagcaaca
    15421 ggacgatgtg ccaacatcgt ccatgaccat cgcggtgcgg attattgtgt tggtgctggc
    15481 gattccgaca accttggtgt gtgtgcttcg agtatgtttc ctcaacattc ctgcaagcaa
    15541 tctggaggcc aaaatgactg agctgttgta gctgtatctg cgcaagttcg ttcttaataa
    15601 cttcggactt gatgactggt tggtgctggt tgctcttgtg agttacgcag ccggtaatat
    15661 ttccccgcgc atgataactg actgactaga tcggagtgga tctgttctct gccctggcgt
    15721 atatcatcac atactatgga ttgggccgac ctatgaaata tgttcctaca gatcatctgg
    15781 ttgtgtttct cacggttcgt acatcgaggc cgagagcttt tacccaaact gatctttgca
    15841 gctcgaatac gcctcacaat gcgcctacct agtcatcgca gcgactgtaa aagcgagcct
    15901 gctcatcttc atcatgcgtc tgttcccgac tcgtttcgtt cacattgccg ggaaagctct
    15961 tcttggtatc atcgcggcct tcaccctctc ggggaccctc gcgctggtct ttcagtgtcg
    16021 cccagtccaa gcggcctacg acaaggctat caccaattct agctgctatc ccactgagac
    16081 ctcgtacgca attcttatga tgcaaggtgt catcatgttc gtgctagatg tatcgatcct
    16141 agtacttccg atatggccta tctggcagtt gcagatgccg ataaggaggc gaatacttgt
    16201 gctggggctg ctctgcattg gtaagctctc gagggaattc aatagtccat taattaagta
    16261 ttgtccaggc ttcaccgcat gtgttgctgc cctcgtgcgc ttctcgacac taaaatttgc
    16321 caatgatacg acgaacttca cctgtatagt tccttccaat gtcggcggga gataaaaact
    16381 gacttccctt agattcagct tccacgtccc tcatttggat ggagattgaa ttcaatctcg
    16441 gccttatgtc agggtctctc ccctctttgc gaaaactttt caagcttggc tctcttttcc
    16501 ccacgagccg ctcaacgaag acacagcaaa gttatacatc ggacttcgag ctgcaccggc
    16561 acagttggac aataactggg attacaaaga agacagaaat ccagagggcc tacgagagaa
    16621 gtgagagcca ggagttcatt gccccaatat atgggcaggg agaattgacc acaactacca
    16681 aagcctatgc ggatggggag acaagctctg ccagtaatgt ttgatgcccg ggccgtgatg
    16741 gctaatgtgt gggatctgtg actcgacgat gtcaatggag acatccaaag tcagagaagg
    16801 tcggatcagg ctcgagaatt ctatccgtga aaattcgatg tattgaatgc ctattactgc
    16861 ctccgttaat gccgagccgg tcggtgtatg agggtcaagc caacgtaatg cccgtatatc
    16921 ccggattggc ttcctatacg cgaaattgac cttggctagc gtgaaggtta atactttacc
    16981 agcccaccca ctggcaggaa tatagacaga gactggccaa agtgttccct acattattga
    17041 tattgctcga ccggaccttg tccaaatggt ttaatcgggg tatatgacta taactgattt
    17101 ctttgaggcg gaagcctgtt tcagttctag ttaggtagca ttgacacata taaggtgtta
    17161 ttgtacagtg taattagagg attctgtcac aaatccatcc gtctagaaga acttgaggag
    17221 tctgtcacga tgttgtacaa ggttctcgtg ttggcgcagc aactgtccca gccgattccg
    17281 tcgccacccc agtttctcct ccaggattag gtgtgtgtat gcgaaaacac tagcatcgaa
    17341 cagacccgga ttcggtcggt cgaagaagtg ttggttgtcg cccagtagcg tagacagtgc
    17401 ctcgaatgca tcgttggctt cggcttccaa ggcgcccaca tcgatataag atgacgtttt
    17461 taggatctct gtccgggcag cttgctggag ttgcagggcg agagcggtcc gcacggcgga
    17521 atttgtactg gacgggttca cgtataatgg tcgagcaacg gcctcgaact cctcagggtc
    17581 caggtataag gtatatagct gccccagtgc cattccagtc agtcacattt catctacgac
    17641 atttcattcc gggggagggg gaccgcaacg cacccaagca tttcgtatcc gatgatccag
    17701 caacgacgca tatacctcga agcgcagatc caactgctgc tcctcctcgc agtgcacttg
    17761 ctcaatggcc catttttgga gcttgctgga aggaataggg gcgttgttgt tgatggggtg
    17821 ggcggggatc aggaaaggaa gggcgccaga gggagatgca tggttgttgg aaggaatcac
    17881 gtcgacgtcg atcccaacga atcttaagta tgcctgcaga gacgcagaga aataacagat
    17941 tagtgatgat gtactggaga cgtggtgtaa tgctgcattt cggagtacgt acctgccact
    18001 tgagacactg tgggttgaac gacggtctgc catgcctggc acttgcggca tcggtgaaga
    18061 catacagtcg attgccacgt ttatctgacc atgcgctgtg cgggagatca ttggaggggt
    18121 aggtgacgag ggggaaacgg tcgaagatgc gcttgattgg tgtaggaacg gagaaaaagt
    18181 ctcgagcgcg cgacaccgtg ctcacattgt ccggtgtctg gccagggtca tcacggtatt
    18241 cgggggtcat
//
