LOCUS       ch1                    15704 bp    DNA     linear   PLN 26-AUG-2019
DEFINITION  Aspergillus niger.
ACCESSION   ch1
VERSION     ch1
KEYWORDS    .
SOURCE      Aspergillus niger
  ORGANISM  Aspergillus niger
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Eurotiomycetes; Eurotiomycetidae; Eurotiales; Aspergillaceae;
            Aspergillus.
COMMENT     'Annotated using funannotate v1.6.0-df4262f'.
            ##antiSMASH-Data-START##
            Version      :: 5.0.0
            Run date     :: 2020-11-03 01:15:18
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 1470356
            Orig. end    :: 1486060
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15704
                     /aStool="rule-based-clusters"
                     /contig_edge="False"
                     /core_location="join{[1475211:1475882](+),
                     [1475942:1477388](+), [1477437:1477528](+)}"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      join(4856..5526,5587..7032,7082..7172)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     cand_cluster    1..15704
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..15704
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="7"
                     /rules="(Terpene_synth or Terpene_synth_C or phytoene_synt
                     or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps
                     or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /tool="antismash"
     mRNA            join(1..40,99..819,899..1019)
                     /locus_tag="KYF_000647"
                     /product="hypothetical protein"
     gene            1..1019
                     /locus_tag="KYF_000647"
     CDS             join(1..40,99..819,899..1019)
                     /codon_start=1
                     /db_xref="InterPro:IPR007062"
                     /db_xref="PFAM:PF04979"
                     /locus_tag="KYF_000647"
                     /note="antiSMASH:Cluster_7; GO_function: GO:0004864 -
                     protein phosphatase inhibitor activity [Evidence IEA];
                     GO_process: GO:0043666 - regulation of phosphoprotein
                     phosphatase activity [Evidence IEA]; GO_process: GO:0009966
                     - regulation of signal transduction [Evidence IEA]"
                     /product="hypothetical protein"
                     /protein_id="ncbi_KYF_000647-T1"
                     /transl_table=1
                     /translation="MSHHMEDAHKRPKGILKNSSSQVPQVAQHAHATLTIPSTSADPTD
                     TKELTLQNTLQNAGRRRSSSNTRPGSSSRRQSLASIHGHHDDSSPRLKWDEANLYLTEQ
                     EKTAKMKIDEPKTPYAPRYDPAEDEDELAGEESLIDAQDIVVDELDKTKKAPKKTVAED
                     DIPELELGEAEEYGGDAHMGDADRIVRERSLSNDSHRGGKHVVVGAGELNGETESGGDT
                     LMTAGEAEEKHRQFEQHRKKHYEMRNIKDLLAHPEDLEDEMDEDEDEGDSSSAAVPPPM
                     PRIPERFLNGGK"
     mRNA            join(2754..3517,3608..4241)
                     /gene="SFH5"
                     /locus_tag="KYF_000648"
                     /product="Non-classical phosphatidylinositol transfer
                     protein (PITP)"
     gene            2754..4241
                     /gene="SFH5"
                     /locus_tag="KYF_000648"
     CDS             join(2754..3517,3608..4241)
                     /codon_start=1
                     /db_xref="InterPro:IPR001251"
                     /db_xref="InterPro:IPR011074"
                     /db_xref="InterPro:IPR036273"
                     /db_xref="InterPro:IPR036865"
                     /db_xref="PFAM:PF00650"
                     /db_xref="PFAM:PF03765"
                     /gene="SFH5"
                     /locus_tag="KYF_000648"
                     /note="antiSMASH:Cluster_7"
                     /product="Non-classical phosphatidylinositol transfer
                     protein (PITP)"
                     /protein_id="ncbi_KYF_000648-T1"
                     /transl_table=1
                     /translation="MADQPEKTAAAPAAPEAQPPTTATTTTEPAVSESQTQPEPQPEAE
                     QKVEQATTGEEASPAPAATEPPVTEPTPAPAQEAPEDKKEEAPKEETKETKAEESKEEQ
                     KAEEPAAEPKAEAAKEEEQKPAQPEYLAKNPALSQFFDRLSAILSSTGHNEMWGVTLKD
                     SSDVPTVNILIKFLRANEGNVKLAEEQLTKALQWRKEMNPLALTEGRYSAERYGGLGYV
                     TKYPEANGKETIVTWNVYGNVKSIDQTFGDVDGFIKWRVALMELAVKDLKLSEATTVID
                     YDGEDPYQMLQVHDYQNVSFLRLNPTIKAASKKTIEVFSMAYPELLREKFFVNVPAIMG
                     WMFAAMKVFLSKNTTRKFHPISNGANLAREFPSLKDKFPKTYGGNGATLEEDAFTVNLE
                     KAEPAPEAPKEEPKEESKQEQAEAPKEEVKEEAKEEAKTEQPAAEEPAKAEAAVTTQEA
                     PAAAEAK"
     mRNA            join(4856..5526,5587..7032,7082..7172)
                     /locus_tag="KYF_000649"
                     /product="terpene cyclase"
     gene            4856..7172
                     /locus_tag="KYF_000649"
     CDS             join(4856..5526,5587..7032,7082..7172)
                     /codon_start=1
                     /db_xref="InterPro:IPR002365"
                     /db_xref="InterPro:IPR008930"
                     /db_xref="InterPro:IPR018333"
                     /db_xref="InterPro:IPR032696"
                     /db_xref="InterPro:IPR032697"
                     /db_xref="PFAM:PF00432"
                     /db_xref="PFAM:PF13243"
                     /db_xref="PFAM:PF13249"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: terpene_cyclase"
                     /gene_kind="biosynthetic"
                     /locus_tag="KYF_000649"
                     /note="BUSCO:EOG09260SIZ; antiSMASH:Cluster_7;
                     GO_component: GO:0005811 - lipid droplet [Evidence IEA];
                     GO_function: GO:0016866 - intramolecular transferase
                     activity [Evidence IEA]; GO_function: GO:0000250 -
                     lanosterol synthase activity [Evidence IEA]; GO_function:
                     GO:0042300 - beta-amyrin synthase activity [Evidence IEA];
                     GO_process: GO:0016104 - triterpenoid biosynthetic process
                     [Evidence IEA]"
                     /product="terpene cyclase"
                     /protein_id="ncbi_KYF_000649-T1"
                     /sec_met_domain="terpene_cyclase (E-value: 3.1e-15,
                     bitscore: 52.5, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MSGSHIGPWRTPAQGHLTPDANGDLKTDYTRWRLRDDRGRQTWHY
                     LESDAENEQWPQSIADKYFLGLPTGLPELPKPQTPLQCAENGLEFFSKLQLEPGNWACE
                     YGGPMFLLPVLIITYYVTKTPIPPEYATEIKRYLFARQHPEDGGWGLHIEAHSSVFGTC
                     MNYVTLRLIGVSEDDPRMIKARGLLHQFGGAIYGPHWAKFSLAVLGVMDWECVNPVPPE
                     IWLLPDWVPFAPWRWWIHIRQVFLPMSYLWSKRFSHPLDPLTKQLRQELYTQPYDSIDF
                     AAHRNSIHKADNYYPKTWLLNTLNSLLVNIWNPYLRVPAIVRRAEEWTWELVRMEDENT
                     DYAGLGPVSNPFNMIVCYEHDGPDSYSVRRHRERLHDYMWMKDEGMLMNGTNGVQVWDT
                     AFITQSIVVAGFGDDPKWRPMLTKALEFLEDHQLRENVPGQEKCYRQHRKGAWPFSNKT
                     QGYTVSDCTAEGLRSTIQLQEMHNFPKLISEERLKDSVDCLLLMQNPTGGFTEYETTRA
                     SEKVEWLNAAEVFGGIMIGYDYPECTTASVTALSLFSKYYPNYRAAEIKSAKEKAVQYI
                     KRVQRADGSWYGSWGICFTYAAMFALESLASIGETYETSADSRRGCEFLISKQKEDGGW
                     GESYLSSEKHVYVQHEKSQVVQTAWASLALMEAGYPHKEPLRKAMQLLMSRQQANGEWL
                     QESIEGVFNQSCMISYPNYKLYWPIRALGLYARKFGNEELV"
     mRNA            join(7585..8382,8438..9028)
                     /locus_tag="KYF_000650"
                     /product="hypothetical protein"
     gene            7585..9028
                     /locus_tag="KYF_000650"
     CDS             join(7585..8382,8438..9028)
                     /codon_start=1
                     /db_xref="InterPro:IPR007052"
                     /db_xref="InterPro:IPR007699"
                     /db_xref="InterPro:IPR008978"
                     /db_xref="InterPro:IPR011990"
                     /db_xref="PFAM:PF04969"
                     /db_xref="PFAM:PF05002"
                     /locus_tag="KYF_000650"
                     /note="BUSCO:EOG09264LH2; antiSMASH:Cluster_7; GO_function:
                     GO:0005515 - protein binding [Evidence IEA]"
                     /product="hypothetical protein"
                     /protein_id="ncbi_KYF_000650-T1"
                     /transl_table=1
                     /translation="MNAASLGDTALQQSDPHTATIHYTTALLTHPRSPSYFIKRSTAFS
                     RLKPTPNLSAALRDAESAVLLARERGKRELIVEAQMRRAIVLFLMGRYVAAEGVVGVVE
                     GMIGLDKDGNGGEDKEEKVRKAMGGGAGKGIEAEVRIWGAKIRAKVNGLGEQSGERGEK
                     VEEVPVGVKVPGEKELRGQLEELRGGKVGEGIGGEEKQSQKVEDKVEEKGRAEVKETQQ
                     QQQQQQQQVKVRHEWYQSGETVVVTLYVKGVPKDKVAIELKEDSTSIQFPLPSGAEYDF
                     TLDPLFAPIDPSTSKVSVFSTKIEISLRKKTPGQKWSALESTTGPVISTPQPTVTPTTT
                     TTQAQAPSYPTSSRHGAKDWDKLASSLTQKSKKDKTKSSSKPKDEQGEGEEDDGEASDA
                     ESINSDFGGGDAVDGFFKKLYANADPDTRRAMVKSYVESQGTSLSTNWDEVGQGPVKVR
                     PPSE"
     mRNA            complement(join(9595..10696,10754..10809))
                     /locus_tag="KYF_000651"
                     /product="hypothetical protein"
     gene            complement(9595..10809)
                     /locus_tag="KYF_000651"
     CDS             complement(join(9595..10696,10754..10809))
                     /codon_start=1
                     /db_xref="InterPro:IPR006603"
                     /db_xref="PFAM:PF04193"
                     /locus_tag="KYF_000651"
                     /note="EggNog:ENOG41; antiSMASH:Cluster_7"
                     /product="hypothetical protein"
                     /protein_id="ncbi_KYF_000651-T1"
                     /transl_table=1
                     /translation="MFPAVTGNIDLEALSGICGSISIACWVVVFSPQIIENFRRGSADG
                     LSLLFLIVWLAGDVFNILGAVLQGVLPTMIILAVYYTLADVVLLAQCFYYRGFTLRDEP
                     SSPPRPVSPITAETYDEDTEIPSPVVPRKPTERTALLTSKQRSASYQAPLDTRSPASSA
                     TITPHHQPLLAHRRHSASSFLHTTVDGTHLSPVTPLVEPAKQPRPPRTLTLLQATFFNG
                     SAIILVCAAGILGWYISQTSSLSSDKNNNNKHKDSPDDLKMDTLGQVFGYLCAVLYLGS
                     RLPQILLNYRRKSTDGVSLLFFLFACIGNLTYVLSILAYSPVCERSHHGRCRSDELASL
                     YGRYILVNLSWLIGSFGTLLLDMCIFIQFFLYQDANGGEVDAEAR"
     mRNA            11244..12467
                     /locus_tag="KYF_000652"
                     /product="hypothetical protein"
     gene            11244..12467
                     /locus_tag="KYF_000652"
     CDS             11244..12467
                     /codon_start=1
                     /db_xref="InterPro:IPR003000"
                     /db_xref="InterPro:IPR026590"
                     /db_xref="InterPro:IPR026591"
                     /db_xref="InterPro:IPR029035"
                     /db_xref="PFAM:PF02146"
                     /locus_tag="KYF_000652"
                     /note="EggNog:ENOG41; antiSMASH:Cluster_7; GO_function:
                     GO:0070403 - NAD+ binding [Evidence IEA]"
                     /product="hypothetical protein"
                     /protein_id="ncbi_KYF_000652-T1"
                     /transl_table=1
                     /translation="MINQRPSEPSLLEASTSINHVASMTAPAIRIPFTGPLPPPIIVPP
                     SARTVAGAIDALLAFLTAPPSPYLRGVDVGRHSQTVLLTGAGISVASGLSDYRGENGTY
                     ITNKTYRPIYYHEFVARHEFRKRYWARSFIGWPGLLKAKPNSTHWAIKDIGTKGYISSV
                     VTQNVDSFHSVAHPELPTLELHGYLRSAVCINCRTQVPRDEFQQSLERLNPAWAEFLKK
                     MVDIGALNADNPEEQRRRGLKINPDGDVDLPEAPYSTFRYPACPTCLEKPPRLQDGSQS
                     RVEVERDGAWLPSSTAGILKPAVIMFGENIDPAVRLGAEEAIDDAGRLLVLGSSLATYS
                     AWRLVERAYKRGMPIGIINIGGVRNESILFSKAEQETEAVCRHVRCSLPSQDILGPVAA
                     QLPSLTHH"
     mRNA            join(12832..13056,13139..13162,13230..14144)
                     /gene="PHO85_1"
                     /locus_tag="KYF_000653"
                     /product="negative regulator of the PHO system"
     gene            12832..14144
                     /gene="PHO85_1"
                     /locus_tag="KYF_000653"
     CDS             join(12832..13056,13139..13162,13230..14144)
                     /codon_start=1
                     /db_xref="InterPro:IPR000719"
                     /db_xref="InterPro:IPR008271"
                     /db_xref="InterPro:IPR011009"
                     /db_xref="InterPro:IPR017441"
                     /db_xref="PFAM:PF00069"
                     /db_xref="PFAM:PF07714"
                     /gene="PHO85_1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs)
                     SMCOG1030:serine/threonine protein kinase (Score: 171.7;
                     E-value: 3.5e-52)"
                     /gene_kind="regulatory"
                     /locus_tag="KYF_000653"
                     /note="antiSMASH:Cluster_7; GO_function: GO:0005524 - ATP
                     binding [Evidence IEA]; GO_function: GO:0004672 - protein
                     kinase activity [Evidence IEA]; GO_process: GO:0006468 -
                     protein phosphorylation [Evidence IEA]"
                     /product="negative regulator of the PHO system"
                     /protein_id="ncbi_KYF_000653-T1"
                     /sec_met_domain="Pkinase (E-value: 2.7e-76, bitscore:
                     252.5, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MDMDGRDRSKSRTLQPPTADYLDLISNLASPKTFLFHHPRSTSRS
                     HPTPAAQSTTVAPSTTMDKQQPSSFQQLEKLGEGTYATVFKGRNRQTGELVALKEIHLD
                     SEEGTPSTAIREISLMKELKHESIVSLYDVIHTENKLMLVFEYMDKDLKKYMDTRADRG
                     QLDQATIMSFMHQLLKGIAFCHENRVLHRDLKPQNLLINKKGQLKLGDFGLARAFGIPV
                     NTFSNEVVTLWYRAPDVLLGSRTYNTSIDIWSAGCIMAELYTGRPLFPGTTNEDQLIKI
                     FRLMGTPSERSWPGISQLPEYKPNFHVYATQDLSLILPQIDPLGLDLLSRMLQLRPEMR
                     ISAQDALHHPWFRDLPQLQAQLQQQQQQQQQQMAGAYGGMVPPQQTY"
     mRNA            join(14932..15308,15410..15704)
                     /locus_tag="KYF_000654"
                     /product="hypothetical protein"
     gene            14932..15704
                     /locus_tag="KYF_000654"
     CDS             join(14932..15308,15410..15704)
                     /codon_start=1
                     /db_xref="InterPro:IPR007128"
                     /db_xref="PFAM:PF03980"
                     /locus_tag="KYF_000654"
                     /note="antiSMASH:Cluster_7; GO_component: GO:0000818 -
                     nuclear MIS12/MIND complex [Evidence IEA]"
                     /product="hypothetical protein"
                     /protein_id="ncbi_KYF_000654-T1"
                     /transl_table=1
                     /translation="MSTEPNPSAQRPGASPSPPPPAPVPLTPGPRASKLQEIFDKALAR
                     TLRANSYANFSGCFPTPAKHVPASLESVWRQLNAKLEESAKAEFEDILAERDAVRQLNE
                     LDRLVGEAKVRKDRGVGGDSVAPHTLSPEELYKAHLLPHLMETQADLDAKINSVQNQNA
                     ELAEKVQAQRSEIESLLSGLEAVVADLEGAAAATTQFTSEHQLRQEAAQMDGEVKARSE
                     I"
ORIGIN
        1 atgtctcacc atatggagga tgcacacaag cgacccaagg gtaaacaaac ctcttgcgat
       61 catccgcatc ctacgcctgg ttgctaatcg gacagcaggt attctgaaga actccagctc
      121 tcaggtgccc caggtcgcgc agcatgctca cgctactttg acgatccctt caacctcggc
      181 cgaccctacg gacaccaagg aacttacgct tcagaacacc ctacagaatg ccggtcgacg
      241 tcggtcgtca tccaacactc gccccgggtc ttcgtcgcga cgacagtctc ttgccagcat
      301 ccacggtcat cacgacgact cgtcgccccg cctgaagtgg gacgaggcca acctgtattt
      361 gacggagcag gagaagacgg ccaagatgaa gatcgatgag cccaagaccc cctatgcgcc
      421 gcgctatgac cccgccgagg atgaggacga gctggcgggc gaggaaagtc tgattgatgc
      481 gcaggatata gtggtggacg aactggacaa gacgaagaag gcgcccaaga agacggtcgc
      541 agaggacgat attccggagt tggagctggg agaggccgag gagtatggtg gtgatgcgca
      601 tatgggagat gccgatcgga tcgtgcgcga acgaagcttg agcaatgact cacatcgggg
      661 cgggaagcac gttgtggtcg gggctggcga gctgaacggc gaaaccgagt ctggtggaga
      721 tacgttgatg acggcgggcg aagccgagga aaagcatcgc cagttcgagc agcatcggaa
      781 gaagcactat gagatgcgga acatcaagga tctccttgcg taagttgctc ccctattccc
      841 aggatggctg tgggatttct catggaggta tggtatactg acgggctttg ttttccagcc
      901 accctgagga tctcgaggac gaaatggacg aagacgaaga tgagggggac agctcaagtg
      961 ccgcggtgcc gcccccgatg cctaggatcc cggagcgatt tctaaatgga ggaaagtgag
     1021 ggagcgaaag gaatggacgg acgggactaa gttatcactc tactcgagaa ggattaggac
     1081 gagaagaggt gataggaaaa taggatggag ggagggacta gttgattctt gctgcataaa
     1141 cggactctgt atattcccca gcgttgttta gtcatgatgg gacggacttg tatgaatcta
     1201 tgggaagtac tttgcttttt tttttttttt tttttttttt ttttttcttc ttctctagtt
     1261 gttcactctt cctgctagct gatgtggatt gtgtcggctc ttttttttct ctcatagcga
     1321 atgatgggtt gcttgatcga ttgatagacg agagagataa aaatgaaatg tacggggagg
     1381 ggagagagtt atggattatt gacacgtctt gtttaaaaac tagatacgat gaagtaaatg
     1441 agctagctgt cagggaaata acccacccga agcagggaga gttctagact gtttgtctga
     1501 ccacagcagg ccagggggga ctcgtcaccc tcggggttat atgagtcgcg tcaaaaaata
     1561 gaatcatcca atactctggg aagtactccg taaaccgaat caaaccaaca tagaagatat
     1621 aaaaaaaaaa aaaaaaaaga aaaaaaaaaa aatagggaac caatgccatt agagaaggtg
     1681 ataagtagtc accttgagtc cgcggccaga ctactctgag taatagtgag ttagagcacg
     1741 cgcctctccg ctaagcccga ggctgtcaaa tcatccgacc acctgagaca agaagaataa
     1801 ttatagtatc agaatccaag agtcggcatc tcaaccaacc ctcgagtcgg tgccttgcat
     1861 gtcatctgga ggaagtgagt ggatgtgatc agtcaccgca tgctgtaacc tgtcaggggc
     1921 attctggggt ttttcttggt gagtctgtct gtcggtctct ctctctcctg aaacatcctt
     1981 gcaggcccac tccaagattc aggaggatgg gatggatcat tttcggtttc ctagtcgagt
     2041 tgctattctg agtaacttgg ttagttagtt attctactgt actacggagt actagctatg
     2101 tactctgtgt gtgtgtgtgc cttccttcac ttccactcaa tggatcagat gttgaatcaa
     2161 gtataaggtt tgtgctgggt tctactatta tctagtagtg aagagtcatg gtatatgact
     2221 tttcaaccat gggatggatc catattttaa gttgtttgtt tggtctactc tggatctggt
     2281 ctgaaacctt ccagatgaca gagaaatcga tagataaata aaacaaatca gttagttgtc
     2341 ttgtctgatc gccgttgaaa cctcctaatt gaaattaacg gccgctgcag caattaatta
     2401 attaatccac tgctatctct gattggattg cgcgcgtttt ctgtgctttc ttagtttcgt
     2461 ctttgcctgc ttgtcgcttc gcttcgtttc tttcgcgctt tctgtctttt ctggtctctc
     2521 gtgtttttct tctcttctcc tcttcctctt ttctcttcct ctctctctct ctctctctct
     2581 ctctctctct ttttctcccc tgctgttcat ttccacggct gttattggaa agccatcccg
     2641 ctcgcgtccg atcgcatcac gcaattccat acattcattt taattcttat ttcccctctc
     2701 tctatctttc actaatctac tgctaccaaa taatacatcc cactacatcc atcatggccg
     2761 atcagcccga aaagaccgcc gccgctcctg ctgcccccga ggcgcaaccc cccaccaccg
     2821 ccactactac taccgagcct gcggtttcgg agtctcagac tcaacctgaa cctcagccag
     2881 aagccgaaca aaaagtcgag caggcgacga caggagaaga agcatctcct gcccccgctg
     2941 ccacggaacc tcccgtgacg gaacccactc ccgctcccgc ccaggaggcc cccgaggata
     3001 agaaggagga agcacccaag gaagagacca aggagaccaa ggctgaggaa tccaaggagg
     3061 agcagaaggc cgaagagccc gcggctgagc ccaaggccga agcagcaaag gaggaggaac
     3121 aaaagcccgc tcagcccgag tatctggcca agaacccggc cctgagccag ttcttcgatc
     3181 gtctgtctgc cattctctcc tccactggcc acaatgagat gtggggtgtc accctcaagg
     3241 actcctcgga tgtccccacc gtcaacattc tcatcaagtt cctgcgcgcc aacgagggta
     3301 atgtcaagct ggccgaggag cagctgacta aggccctgca atggcgcaag gagatgaacc
     3361 ccctcgccct gaccgagggc cgctacagtg ctgagcgcta tggtggtctg ggctatgtca
     3421 ccaagtaccc cgaggcgaat ggcaaggaga ccattgttac ttggaacgtc tatggtaatg
     3481 tcaagtctat tgatcagacc tttggcgatg tagatgggta agtgctgctg ctgctgctgc
     3541 tgctgctgct gctgttgctg ctgctatttc ggaattaaaa agagggttag atctaactgt
     3601 cgcctaggtt catcaagtgg cgtgtcgcgc tcatggagct cgctgtcaag gacttgaagt
     3661 tgagtgaggc gacgaccgtg atcgactacg acggtgagga tccgtaccag atgctccagg
     3721 tccacgacta ccagaacgtc agcttcctcc ggctgaaccc caccatcaag gcggccagca
     3781 agaagaccat cgaggtgttc tccatggcct accccgagct gctgcgggag aagttcttcg
     3841 tcaacgtgcc tgccatcatg ggctggatgt tcgccgccat gaaggtcttc ctcagcaaga
     3901 acaccacccg caagttccac cccatctcca acggtgccaa cctggcccgc gagttccctt
     3961 ccctgaagga caagttcccc aagacctatg gtggtaacgg cgcgaccctg gaggaggatg
     4021 cgttcacggt caacctcgag aaggccgagc ctgccccgga ggctcccaag gaggagccta
     4081 aggaggagtc caagcaggag caggccgagg ctcccaagga agaggtaaag gaggaggcca
     4141 aggaggaagc caagacagag cagccggcgg ccgaggagcc ggccaaggca gaggctgcag
     4201 tgacgaccca ggaggcgccc gccgcagcgg aagccaaata aaaagctagc aagaggcgta
     4261 attcacacct ggtcggaatg aggccaggat cacataattt acggtaatgg atgggacagg
     4321 ttggattgat acccggggga atcggtagaa tgattccgtg tcgttttgcg tacttgatac
     4381 ctctcgatag tgtgtgcttt atatgttctg ggattgatga tggagtgcag aaacactaga
     4441 tagtaatatt taatgtaaca ggtcatatag ccgctgattt aacgttacga tgtttctctc
     4501 gcgtcgaccg ttattccatg cgttcctgca tgcagcagta aactataaca ctggatttcc
     4561 tgctctcttt atgctgatct ccagccaggc acccctgatg actcagcagc cagtgtccct
     4621 cagtttcctg caccaacaaa aacaccaact gcacagctgc tgcacgaaca acaggcagca
     4681 aataaaatcc gggcaaggga gattagtgtg ttgttcttcc tttctctcct ctcgagtgtg
     4741 gttgtatcct ataagctatc cctcccacta tccctctctc cactaatctc aaccctgcca
     4801 ttccaccctt tcaacccccc ccaataccat aagtgtacaa caacccccca tcacaatgtc
     4861 gggatctcac atcggcccgt ggagaactcc cgcccaaggc catctcaccc ccgacgccaa
     4921 cggcgatctc aaaactgact atacgcgctg gcgcctccgc gacgaccgcg gccgccaaac
     4981 ctggcactac ctggaatccg acgcagagaa cgagcaatgg cctcaatcca tcgcagataa
     5041 gtacttcttg ggtctcccca cgggacttcc cgagctcccc aaaccccaga cgcctctgca
     5101 atgcgccgag aacgggctgg agttcttctc caagttgcag ctggagccgg gaaattgggc
     5161 gtgcgagtat ggcgggccca tgttcttgct gcctgtcttg attatcacgt actatgttac
     5221 taagacgcct attccgccgg agtatgccac cgagattaag cggtatttgt ttgctaggca
     5281 gcatcctgag gatggcggct gggggttgca tattgaagct cacagttctg tgtttggtac
     5341 ttgtatgaat tatgttacgt tgaggttaat cggtgtgagc gaggatgatc ctaggatgat
     5401 caaggccagg gggttgttgc atcaatttgg aggtgccatc tatgggcccc attgggcgaa
     5461 attctcgctg gctgtcttgg gtgtgatgga ttgggagtgt gtgaatccgg tgccgccgga
     5521 gatttggtac gtttgtttct atcatgtcta gtgggtgatt tgtggatggg atactgattc
     5581 gaccaggcta cttcctgact gggtgccgtt tgcgccctgg cgctggtgga ttcatattcg
     5641 ccaggtcttt ctgcccatgt cgtatctgtg gtctaagagg ttctcgcatc ccttggaccc
     5701 tctcaccaag cagctgcggc aggagctgta tacccagccg tatgactcga ttgactttgc
     5761 ggcgcatcgc aactcaattc acaaggcaga caattactac cccaagactt ggctgctgaa
     5821 taccttgaac tctctgctcg tcaacatctg gaacccctac cttcgtgtcc ctgccattgt
     5881 gcgtcgcgcg gaggagtgga cgtgggagtt ggtccgcatg gaggacgaga ataccgacta
     5941 cgctggcctg gggcctgtga gcaacccgtt caacatgatt gtgtgctacg aacatgacgg
     6001 tccggacagc tactcggtcc gtcgccatcg cgaacggctg cacgactaca tgtggatgaa
     6061 ggacgagggc atgctgatga acggcaccaa cggcgtccag gtatgggata cggcctttat
     6121 cacgcagagt atcgtggtgg ccgggttcgg cgatgacccg aaatggcggc ccatgctcac
     6181 caaggcactg gagttcctgg aagaccatca gctgcgcgag aacgtgccgg gccaggagaa
     6241 gtgctaccgc cagcaccgca agggcgcatg gccattcagc aacaagacgc agggatacac
     6301 ggtcagcgac tgcaccgccg agggactgcg ctcgaccatc cagctgcagg agatgcacaa
     6361 cttcccgaaa ctgatctcgg aggagcgatt gaaggacagc gtcgactgcc tgctcctgat
     6421 gcagaacccc actggtgggt tcaccgagta cgaaaccacg cgggcatccg agaaagtcga
     6481 gtggctcaac gcagccgagg tattcggcgg aatcatgatc ggatacgact atcccgagtg
     6541 cacgaccgcg tccgtcaccg cgctctccct cttcagcaaa tactatccga attaccgggc
     6601 cgcagagatc aagtccgcca aggaaaaggc cgttcagtac atcaagcggg tgcagcgcgc
     6661 cgatggcagc tggtacgggt cctggggcat ctgcttcacg tacgcggcga tgtttgccct
     6721 ggagagtttg gccagcatcg gagagacgta cgagacgagc gcggactccc gacgcggatg
     6781 cgagttcctc atctcgaagc aaaaggagga cggcggctgg ggcgagtcgt acctcagcag
     6841 cgagaagcac gtctatgtgc agcacgagaa atcgcaggtc gtgcagacgg catgggccag
     6901 tctggcattg atggaggccg ggtatccgca taaggagccg ctgcggaaag caatgcagct
     6961 gctgatgtcg cggcagcagg ccaatggaga gtggttgcag gagtcgattg agggagtgtt
     7021 taaccaatct tggtgagtat catgatcgat tgattgagag ttctccacta acgagtgaca
     7081 gcatgatttc gtatcccaac tataagctgt actggccgat ccgggcgttg ggattgtatg
     7141 cgcgcaagtt tggcaatgag gagttggtct gatcttctat gaattgttct tctatgagta
     7201 catgtattac tactatacta ctataacctt ctactaattg ataatatgat tcatgtatac
     7261 tatcttcttt atcgttgatc tggagagttt agatgtgtag ccaatcacgt ggatgctccg
     7321 ctccccgcat ctctccaaag aagatcatcg aacttgtttc cattccattc acctctccac
     7381 ttgtattcct ctttctctta cacattattt ccttttctct tcggagattc ccttacaaac
     7441 aacaagactc atttttcaca tctcgtactc agacccatac ttaaacccta tctacccacc
     7501 caacaaacac aacacaacac agcacaacgc aacacctcca tccaaacacc accacactcc
     7561 aacccaccac ctcaaaacct caaaatgaac gccgcctccc tcggcgacac cgccctccaa
     7621 cagtccgacc cccacaccgc aacaatccac tacacgaccg ccctcctcac gcacccccgc
     7681 tcgcccagct acttcatcaa acgctcaaca gccttctcac gcctaaagcc cacaccgaac
     7741 ctctccgccg ccctccgcga tgccgaatcc gccgttcttc tcgcccgcga gcgggggaaa
     7801 cgcgagctga tcgtcgaggc gcagatgcgg agagccatcg ttttgtttct catggggaga
     7861 tacgttgctg cggagggggt ggtaggcgtg gtggagggta tgattggatt ggataaggac
     7921 ggtaatggtg gggaagataa ggaggagaag gtgaggaagg cgatgggggg tggtgctggg
     7981 aagggtattg aggcggaggt gaggatttgg ggggcgaaga ttagggcgaa ggtcaacggt
     8041 ttgggcgagc agagtggtga gcgtggggag aaggtggagg aggttccggt gggggttaaa
     8101 gtgccggggg agaaggagtt gaggggacag ttggaggagt tgaggggagg gaaggttggt
     8161 gagggtattg gtggtgaaga gaagcagagt cagaaggttg aggataaggt ggaggagaag
     8221 gggagagctg aggtcaagga gactcagcag cagcaacaac agcagcagca gcaggtcaag
     8281 gtccgtcatg aatggtacca gtccggtgag acggttgttg tgacgcttta cgtgaaaggc
     8341 gtgcccaagg ataaagtggc tattgagctg aaagaggact cggtatgtat tcactcccct
     8401 tgacttaaac atgcaagtca ctaacctata tacatagaca tccatccaat tccccctccc
     8461 ctccggcgcc gaatacgact tcactctcga cccgctcttc gctcccatcg acccctccac
     8521 ctctaaagtc tccgtcttct ccacaaagat cgaaatctcc ctgcgcaaga aaactcccgg
     8581 ccagaaatgg agcgccctgg aatctaccac cggacctgtc atctctactc cccagcccac
     8641 ggttacaccc accactacca ccacacaagc ccaagcccca tcatacccca cctcctcccg
     8701 ccacggcgcc aaagactggg acaagctcgc ctccagccta acccagaaat cgaaaaagga
     8761 caagaccaag agcagctcaa agcccaagga tgaacaagga gaaggagaag aagatgatgg
     8821 agaagcatcc gacgccgaat ccatcaactc cgacttcgga ggcggtgatg ccgtcgatgg
     8881 cttcttcaag aaactctatg ccaatgcgga cccggatacc cgccgcgcta tggtgaagag
     8941 ttatgtggag agtcagggga cgtcgctgag tacgaattgg gatgaggttg ggcaggggcc
     9001 ggttaaggtt aggccgccta gtgagtgatt ttctttcttc ttttctttct cagtttctga
     9061 gagaaaggaa agaggggagc aagaaagaat tgttggttga aagatggaga agaagggggt
     9121 atgcgaattg caagcgtgga gttatggtct acatccatgt tgtgggtgca tgtgggtggt
     9181 gttttaggtt ctgaagttgc ttcccttgct agttacttgt tttgtgtagc ttagcttagc
     9241 tctgctttac ttgtgtaatg gtaatcattg caagatgtcg agactctgct attacttacc
     9301 ttataaacat gatacgtaga ctactacatg atacacgtga tgtagaagca agtatagtat
     9361 aagataataa ataattatat acacgaaaag caactccgat ccaatcaaac gccaatcaca
     9421 tgagcaagag tagcatagca acctggccat atagcacgca agcgttttca gaataaatca
     9481 ttataaatca agcaatccct aagtaccaac cccaacacct ctttatgtct tcccagaggc
     9541 ataatcaaga aaagagaata aacaagagag aaatgtaaac cacatgcgaa tattttacct
     9601 cgcctctgca tccacctcac ccccattcgc atcctggtac aagaaaaatt gaataaagat
     9661 acacatatcc agcaataacg tgccaaagct cccaatcagc caagacagat tgaccaggat
     9721 atatcgacca tacagcgatg ccagttcatc agatcgacac cgaccatgat gcgagcgttc
     9781 acacacaggc gaatacgcca agatggaaag gacgtaggtc aaattgccga tacaggcgaa
     9841 gaggaagaag agcagggaaa caccgtctgt tgacttgcgg cgataattga ggaggatctg
     9901 tgggaggcgg gaaccgaggt acaggactgc gcagaggtag ccgaaaactt ggcctagtgt
     9961 gtccattttc aggtcatcag ggctgtcttt atgcttgttg ttgttattct tgtccgatga
    10021 gagtgatgac gtttggctga tgtaccagcc caggatgccg gcggcacaga cgagaatgat
    10081 ggccgaaccg ttgaagaagg tggcttggag cagtgttagg gttcgagggg gacggggttg
    10141 cttggctggt tcgacgagtg gagtcactgg ggagaggtga gttccgtcga cggtcgtatg
    10201 aagaaatgaa gaggcggagt gacggcgatg ggcgagcaag ggctggtggt gaggagtgat
    10261 ggtagccgat gatgctgggc tacgagtgtc caaaggagcc tggtaagagg cactgcgttg
    10321 tttggaggta agcaacgcgg tgcgctctgt gggcttccga ggcacgacag gggagggaat
    10381 ctcagtgtcc tcgtcgtaag tttctgccgt gatgggagag acaggccgcg gcggcgagga
    10441 tggttcgtcg cgcagtgtga atccccgata gtagaagcat tgtgctaaga gcaccacatc
    10501 ggctaaagtg tagtacaccg cgagaattat catggttggc aggacgccct gcaggacggc
    10561 accgaggatg ttgaacacat cgccggcaag ccagacgatg aggaaaagaa gcgaaaggcc
    10621 atcagctgag ccgcgacgaa aattttcaat gatctgtggg gagaagacca ccacccagca
    10681 cgcaatcgag atggatctat cagtgatcag tattgaacat gtccaattct agcatactct
    10741 ggcataaaca tacccacata tgccactcag tgcctctaga tctatattgc cggtgactgc
    10801 gggaaacatg tccgggcggt gcgaacgaga gagcgattgg gcgttttccc aatcaatgct
    10861 ctactctata atctaaacag gaagaggcta gcaaaaccgg tcgacagcaa acaaagacgc
    10921 gttgatggaa tgaagcagat ggccggcgat gacgttcgca gagtctgcga agggtgcaga
    10981 tcacgtggga cgatccgggg tagctcctct cagtctagac caagaatgga cacccagatc
    11041 gacttgcttc cacttttact tcttttggct ggggacgctt tgttccttgt cggccgcaat
    11101 gctctgtatc gtacattctg ggccttctgg tcatctatta ctatctgatc aagtaatact
    11161 tggccccgtg tagtctgacc atccatttca cactcaatgg gactgtgtac atcatgtgac
    11221 cgattagtca agccgtgacg tcgatgatca accagcgccc atctgaaccc agccttctcg
    11281 aagcttcaac atccatcaat catgtggctt caatgactgc tccagcaatt cggattccct
    11341 ttacgggccc tctgcctccg ccgattattg tccctccgtc cgctcgcacg gtcgcaggtg
    11401 ccattgatgc gcttttagcc tttttgacgg ccccaccgtc gccgtacctg cgcggcgttg
    11461 atgtaggcag gcattcccag acagtgctct tgacaggcgc tggtatctcg gtagcttcag
    11521 gcctgtccga ttatcggggt gagaatggca cgtacatcac aaataagacg tatcggccga
    11581 tctactacca cgagttcgtc gctcgccatg agttccgcaa gcgatactgg gcgcgaagct
    11641 tcattgggtg gccggggctc ctaaaggcaa agccaaattc gacgcactgg gctatcaaag
    11701 acattggtac gaaaggctat attagttcag tggtgacgca aaatgtcgac tccttccatt
    11761 ctgtcgcgca tccagaacta cccacactcg aactccacgg ctacttgcgt tctgccgtct
    11821 gcatcaattg tcgaactcaa gtcccgcgag acgagttcca gcaatcgctc gagcggctga
    11881 accccgcctg ggcagagttc ctcaagaaaa tggtcgatat tggcgcgctg aacgcagaca
    11941 accctgagga gcagagacgg aggggcttga aaatcaaccc ggatggcgat gtagatttac
    12001 cggaggcccc ttattcgacc tttcggtatc cagcatgtcc gacgtgcttg gagaagccac
    12061 cccgattgca ggatgggtcc caatcccgtg tggaggtaga gcgcgatggg gcttggcttc
    12121 caagttctac ggcgggaatt ctgaagccgg cggtcattat gtttggagag aatatcgacc
    12181 cagctgtcag gctgggtgca gaagaggcca tcgatgatgc gggcaggctc cttgtcctgg
    12241 gcagcagtct cgccacatac tcggcgtggc gcctagtgga aagggcctat aaacgaggga
    12301 tgccgattgg catcatcaac ataggaggtg tccggaacga gtcgatcctc tttagcaagg
    12361 cggaacaaga gacggaggct gtatgccggc atgtccgttg cagtctcccg tcccaggata
    12421 ttctaggccc tgtggcagca caactgcctt cacttactca tcattagggt ccatgtatag
    12481 attgaaaaaa ggatgtgatg tatagatggc ggtgaggtgt atgaaccgct tacagataag
    12541 catcatagta tatgtacaag cgataaaagt tgaatccaag cttgcattat tggagacgtt
    12601 actattttca aagtaactgt atccatcaga tggaatactc tagaaaagat aattataggc
    12661 actccagaat gattggcaac ggcgagctaa gataggcatg taatagacgc cgggatagtg
    12721 gagaccagca aagtaggaga aggcgagtta caaagtgatg gcgggccagt cagccgcccg
    12781 tccgctgttc gattccagcg cggggctctg cattcgccgg ttcagatcag catggacatg
    12841 gacggtcgcg accgctcaaa aagcaggaca ttgcaacctc caaccgccga ttatctggat
    12901 ctcatctcta acttggcctc tcccaagact tttctctttc atcacccacg ctccacctct
    12961 cgttctcatc caactcctgc tgcgcagagt accaccgtcg caccatcgac caccatggac
    13021 aagcagcagc ccagctcgtt ccagcagctg gaaaaggtgt gttttgatgg cttccctact
    13081 gtctaccaag atatcaccca tcaaatgaga gatttgtgat gctaactgct gattctagct
    13141 tggagaaggc acctatgcca ccgtacgaac ccctccctcc gcacggccga tcctcttaaa
    13201 tcgcactatg tactgacacc ctctcgcagg tcttcaaggg acgcaatcgc cagactggcg
    13261 agctggtcgc cctgaaagag atccatctcg attctgaaga gggaacgcca tccaccgcca
    13321 ttcgagaaat atcgttgatg aaggagctga agcacgagag catcgtgtcg ctctatgatg
    13381 tgattcacac ggagaacaaa ctcatgctcg tctttgagta catggacaag gatctgaaga
    13441 agtacatgga tacccgcgcc gaccgcggcc agttggacca agccacaatc atgtcattca
    13501 tgcaccagct tctcaagggc attgcgtttt gccatgagaa ccgcgtcctc caccgcgatc
    13561 tgaagcctca aaacctcctc atcaacaaga agggacaact taaacttgga gatttcggtc
    13621 tagcccgcgc ctttggcatt cccgtcaata ctttctccaa cgaagtcgtg accttgtggt
    13681 accgtgcccc agatgtgctt ctgggcagcc gcacatacaa cacgagcatc gacatctggt
    13741 ctgctggatg tatcatggcg gaactctaca ctggccgtcc tctgttccct ggcaccacca
    13801 acgaagacca gcttatcaag atcttccgcc tgatgggaac cccttcggaa cgctcatggc
    13861 ccggcatctc ccagctcccg gagtacaagc caaacttcca cgtatatgcg acgcaggatc
    13921 tcagtctcat tctcccccag attgaccccc taggtctgga tctcttgagc cggatgctcc
    13981 agctccggcc agagatgcgg atcagtgccc aggacgccct gcatcacccc tggttccgcg
    14041 atctcccgca attgcaggcc caattgcagc aacagcagca gcagcaacaa caacaaatgg
    14101 ctggggcgta tggtggcatg gttcccccac agcaaacata ttgagttctt cctttgatgc
    14161 gtttctgttt tccttatagt tcgttttcat catgtacagc ctatcgttta ccttgacttg
    14221 cgttcatctg cttcctcgtg gaaggcttga cgagcaacgg attcggtttt agaatgggga
    14281 gcgcggcgtt tgactcctga gaggacattc gaatgattct tgctgttttc tgctttcttt
    14341 gcgttgcata tggacccaga gaaccgatgg catctcgtag ataaacttgg ccattatact
    14401 tatctattgc tctctattac cttccattat cgtagcttat tacaagcgca ggggcagcag
    14461 cgacgatatc ttgtcccgca gacaactaaa tcaatcctga caagccttta tcagtgccgg
    14521 atataagccc taacattcca cgcaaccaag ttgaacacag tagctaatct cggctcgcca
    14581 cgaaaagaca acttacaata aggaccatcc ttatattttt caaactgatt taaacactac
    14641 aaatatacag tagcctacac atcttacttt ataggtacct aaactctgta atatatgtag
    14701 gtactccggt cttctggcgg gatctatatc tatcacgtga ttaatagtcg cgcgcgtctt
    14761 ccggcgcgtc ctccaatccc atcatcaatc tactattctc cataatccta caaccacgaa
    14821 caacaacaac acaaaggagc ttgaaacgaa cttaaggctc agcataacaa atcactgcac
    14881 cccaatcgaa actcttcaac cacctcaaac cctcaaccgg cgaaagtaaa catgtccacc
    14941 gaacccaacc catcagccca aagaccaggc gcctccccct caccacctcc tcccgcgccg
    15001 gtccccctaa caccaggccc gcgcgcctcc aaactacaag agattttcga caaggcgctc
    15061 gcgcgcacgc tgcgcgcgaa ctcgtatgcg aatttcagcg ggtgttttcc gacgccggcg
    15121 aaacatgtcc cggctagctt ggagagcgtg tggagacagt tgaatgcgaa gttggaggag
    15181 agcgcgaagg ccgagttcga ggatattctg gccgagaggg atgctgttag gcagttaaat
    15241 gagttggacc ggttggttgg ggaggcgaag gttaggaagg atagaggagt cggtggggat
    15301 agtgttgcgt atgtctcccc ttccttattc ctttttttgc tatttggcat cattacattg
    15361 ggggcctgtg gatgatggat ggctaactgg aatgatttgt gcttggtagg ccgcatacgt
    15421 taagtccgga ggaattgtac aaagcgcatc tgttgccgca tctgatggag acgcaggcgg
    15481 atttggatgc gaagattaat tcggtgcaga atcagaatgc ggagttggct gagaaggtcc
    15541 aggcgcagag gtctgagatt gaaagtttgt tgtcggggtt ggaggctgtg gttgctgatt
    15601 tggagggtgc tgcagccgcg acgacgcagt ttacgagtga gcatcagctt cgacaggaag
    15661 ctgcgcagat ggatggagag gttaaggcta gatctgagat ctga
//
