LOCUS       ch7                    14425 bp    DNA     linear   PLN 26-AUG-2019
DEFINITION  Aspergillus niger.
ACCESSION   ch7
VERSION     ch7
KEYWORDS    .
SOURCE      Aspergillus niger
  ORGANISM  Aspergillus niger
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Eurotiomycetes; Eurotiomycetidae; Eurotiales; Aspergillaceae;
            Aspergillus.
COMMENT     'Annotated using funannotate v1.6.0-df4262f'.
            ##antiSMASH-Data-START##
            Version      :: 5.0.0
            Run date     :: 2020-11-03 01:15:18
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 732321
            Orig. end    :: 746746
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             join(1..6,165..2138)
                     /codon_start=1
                     /locus_tag="KYF_008966"
                     /note="EggNog:ENOG41; antiSMASH:Cluster_66"
                     /product="hypothetical protein"
                     /protein_id="ncbi_KYF_008966-T1"
                     /transl_table=1
                     /translation="MKVLLTTNSTHRIVIPPGFLLASFFPSLPASAVSSPHLDGQEPAV
                     DWLVPSSCLQILEHCRNAMSRSPFRPSTPATMNAADKQNNGHLAKPLTPALSAAFHRSQ
                     KSPLTPRLATPGGYRTPKRLAASEHPSSAPSKRDPEPSSSSLLSANVTPRSGSRNSRRD
                     GAVSSPNNNNTPTNGQQSPQVTWTQPHVGQLSNTGRLRTERSPVRGAMLEPSRTTRART
                     VTMESNHLSRPNSASDNSAGAPMFFHASDARSTISEQEPRPKLQTKTSGTTFIYANGAQ
                     ERQSPVSEVGGTYKRRSIGLTRSVVSAKPSASPRLRPARVDSNPRLSDGPSVVGSQDDS
                     FEAGSQAHSPPMSSVSARPIPAVRHVKSSSLDSGHSGLSPPQKEGLRPSPLIISPSEPK
                     IDASTIASEPLPGLRPRVFSNGSIASVDTHNSGMQSPSKSESGQANGALNARTERKIMD
                     LEISNSSLLAINRTLEREMRKQNAELRRYRRLSRSGRLSMATSSRSVSGALSIPPEVEE
                     ASEHSSVRSPEELSDFSDEDSLEDGVLSPDSQADQDSQHRARDEKRFLIDLAKHQELLA
                     DSQRLNQSLKRCLGWTEELIREGQRALEYNVHVNDVQLGGRVLTPEELNELNELNELHE
                     QQELEDISRPSSRSDSEPPSEDGS"
     protocluster    1..14425
                     /aStool="rule-based-clusters"
                     /contig_edge="False"
                     /core_location="join{[740284:740352](+),
                     [740439:741499](+), [741551:741734](+),
                     [741782:741890](+)}"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      join(7964..8031,8119..9178,9231..9413,9462..9569)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     cand_cluster    1..14425
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14425
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="5"
                     /rules="(Terpene_synth or Terpene_synth_C or phytoene_synt
                     or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps
                     or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /tool="antismash"
     mRNA            join(1..6,165..2138)
                     /locus_tag="KYF_008966"
                     /product="hypothetical protein"
     gene            1..2138
                     /locus_tag="KYF_008966"
     mRNA            complement(join(2438..3302,3364..3490,3581..4148))
                     /locus_tag="KYF_008967"
                     /product="hypothetical protein"
     gene            complement(2438..4148)
                     /locus_tag="KYF_008967"
     CDS             complement(join(2438..3302,3364..3490,3581..4148))
                     /codon_start=1
                     /db_xref="InterPro:IPR000560"
                     /db_xref="InterPro:IPR016274"
                     /db_xref="InterPro:IPR029033"
                     /db_xref="PFAM:PF00328"
                     /locus_tag="KYF_008967"
                     /note="SECRETED:SignalP(1-20); EggNog:ENOG41;
                     antiSMASH:Cluster_66; GO_function: GO:0016791 - phosphatase
                     activity [Evidence IEA]"
                     /product="hypothetical protein"
                     /protein_id="ncbi_KYF_008967-T1"
                     /transl_table=1
                     /translation="MILLSPLTTALLCLLTLTTATNTTTTTPFNLHSTWGNLSPYTSSP
                     GFGIPPGTPKTCQLTQAHILHRHAQRYPTSYLLDADSMESFAQKLKNYTQAHPNSTLAT
                     GPLSFLNNWRYLMGTEALLPTGAATEATSGAFHWSRYGRVLYDAPAGMADWSNELNVFP
                     NGTRRSKPMFRTTSQARILESARWWLSGFFSNIAANSSSDDYDLVIIPEGDGYNNTLSG
                     SCPNGDTSEGDDSAEQFLKIYTPPIITRFSQYLPSTLNLTYLDILSMQNLCAYETAVLG
                     TSSFCALFTPSEWESYAYILDLQFYGDYGFGSPSGRAQGIGYVLELASRLQGKVIEKQV
                     ANVNITYDSNPSTFPLHQPLYLDMSHDDVIVSVLAALGVEYFNIGKDGMKGNISANEVP
                     LNRTFRLNRIAPFGARFVTEIWRCDSSSAADIEVDAGGEVVYENPTVSEGVGKEYVRWV
                     LNEMPVPVDGVSGCESDGGNGFCSLEGFLGGVKEMQELAGFEEACIEGAGSGGGQVGDG
                     RP"
     mRNA            complement(join(5399..5542,5608..6644,6695..6788,
                     6857..6900,6947..7052))
                     /locus_tag="KYF_008968"
                     /product="hypothetical protein"
     gene            complement(5399..7052)
                     /locus_tag="KYF_008968"
     CDS             complement(join(5399..5542,5608..6644,6695..6788,
                     6857..6900,6947..7052))
                     /codon_start=1
                     /db_xref="InterPro:IPR001623"
                     /db_xref="InterPro:IPR018253"
                     /db_xref="InterPro:IPR026894"
                     /db_xref="InterPro:IPR036869"
                     /db_xref="PFAM:PF00226"
                     /db_xref="PFAM:PF14308"
                     /locus_tag="KYF_008968"
                     /note="EggNog:ENOG41; antiSMASH:Cluster_66"
                     /product="hypothetical protein"
                     /protein_id="ncbi_KYF_008968-T1"
                     /transl_table=1
                     /translation="MVADTSYYDALGVPPTATELEIKKAYRKLAIIHHPDKNPGDETAH
                     ARFQEIGEAYQVLSDEELRKRYDKFGKEDAVPGGGFEDPSEFFGMIFGGNAFVDLIGEI
                     SLMKDLTTTMDITMQQMEEEELAASAEEKLNIHDETQAHAAEGTTEGAAQATPAESTTA
                     ASEKPAAAASPSSGTSTPRRYMGQQAIMDKSEEEARMEAAGLSQEEKELRKKEKKKGGL
                     SREQQERLAAYELERKKAREERVNTLATKLVDKISVWTETDKSPDMTRAFEEKIRLEVE
                     NLKMESFGLEILHAIGATYVQKATSFLKSQKFLGISGFFSRLKDKGTLAKETWTTISTA
                     IDAQMTMEEMAKLEERGGEDWTDEKKAEYEKKVTGKILAAAWRGSKFEIQSVLRDVCDQ
                     VLGDKRIKLDKRVERAHALVIAGNIYSKAERDPDEEGDFMAFEQLMAESMTKKGKEDKK
                     KKKKHEHHHEEPTATA"
     mRNA            join(7964..8031,8119..9178,9231..9413,9462..9569)
                     /gene="ERG6_2"
                     /locus_tag="KYF_008969"
                     /product="terpene cyclase"
     gene            7964..9569
                     /gene="ERG6_2"
                     /locus_tag="KYF_008969"
     CDS             join(7964..8031,8119..9178,9231..9413,9462..9569)
                     /codon_start=1
                     /db_xref="InterPro:IPR002060"
                     /db_xref="InterPro:IPR006449"
                     /db_xref="InterPro:IPR008949"
                     /db_xref="InterPro:IPR019845"
                     /db_xref="InterPro:IPR033904"
                     /db_xref="PFAM:PF00494"
                     /gene="ERG6_2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_kind="biosynthetic"
                     /locus_tag="KYF_008969"
                     /note="BUSCO:EOG09262HA6; antiSMASH:Cluster_66;
                     GO_component: GO:0016021 - integral component of membrane
                     [Evidence IEA]; GO_function: GO:0016740 - transferase
                     activity [Evidence IEA]; GO_function: GO:0016765 -
                     transferase activity, transferring alkyl or aryl (other
                     than methyl) groups [Evidence IEA]; GO_function: GO:0051996
                     - squalene synthase activity [Evidence IEA]; GO_function:
                     GO:0004310 - farnesyl-diphosphate farnesyltransferase
                     activity [Evidence IEA]; GO_process: GO:0008610 - lipid
                     biosynthetic process [Evidence IEA]; GO_process: GO:0009058
                     - biosynthetic process [Evidence IEA]; GO_process:
                     GO:0006696 - ergosterol biosynthetic process [Evidence
                     IEA]"
                     /product="terpene cyclase"
                     /protein_id="ncbi_KYF_008969-T1"
                     /sec_met_domain="phytoene_synt (E-value: 4.3e-09, bitscore:
                     32.3, seeds: 8, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MGLASNAIYYTFHPSELRSILQWKIWHSPVHERNEKNETETEKAC
                     FKFLDLTSRSFSAVIKELHPELLMPVCVFYLTLRGLDTIEDDTSIALETKEPLLRGFKD
                     FLEQDGWTFNGNRPEEKDRELLVQFHNVITEFKKMKPAYQAIIKDITDKMGNGMADYCR
                     KAAFDDASVITVEEYDLYCYYVAGLVGEGLTRLFVEAEFGNPALLERARLHKSMGLFLQ
                     KTNIIRDIREDDDDGRRFWPKEIWSKHVKQFDDLFKPEHREAALNCSSEMVLNALEHVE
                     DCLFYLAGLREQSVFNFCAIPQSMAIATLELCFRNPAIFERNIKITKGEACQLMFESTQ
                     NLRILCAAFRKYARKIHKKNTPKDPNFLKVSLVCGRIEKWIETIFPSQNAEAAKRRVTG
                     ELTEQEKKQAEEHAETRKDMYFMMGLMVVIVFITSVVMIFTAWLLGARFDLAWQELRSG
                     NFRPPREIRQKQEL"
     mRNA            complement(join(10116..10259,10345..10452,10524..11531))
                     /gene="GPI14"
                     /locus_tag="KYF_008970"
                     /product="GPI mannosyltransferase 1"
     gene            complement(10116..11531)
                     /gene="GPI14"
                     /locus_tag="KYF_008970"
     CDS             complement(join(10116..10259,10345..10452,10524..11531))
                     /codon_start=1
                     /db_xref="InterPro:IPR007704"
                     /db_xref="PFAM:PF05007"
                     /db_xref="PFAM:PF06728"
                     /db_xref="PFAM:PF09594"
                     /gene="GPI14"
                     /locus_tag="KYF_008970"
                     /note="CAZy:GT50; BUSCO:EOG09261XAF; antiSMASH:Cluster_66;
                     GO_component: GO:0016021 - integral component of membrane
                     [Evidence IEA]; GO_function: GO:0016758 - transferase
                     activity, transferring hexosyl groups [Evidence IEA];
                     GO_process: GO:0006506 - GPI anchor biosynthetic process
                     [Evidence IEA]"
                     /product="GPI mannosyltransferase 1"
                     /protein_id="ncbi_KYF_008970-T1"
                     /transl_table=1
                     /translation="MPSKMASFFQTPSLVYTSAIALRAILLIYGAWQDANSAVKYTDID
                     YLVFTDAARYVSHGASPYERDTYRYTPLLAWLLLPTSWSGPSFLFSFGKALFALSDVLA
                     GWLIARSLVSAYGMDAPRALKYASFWLLNPMVANISTRGSSEGLLGVLVIALLWAVLRR
                     RVVLAGVLLGLSVHFKIYPFIYGVSILWWLDRERDGSSSSSTSKNNAGDANIITKTINF
                     ITPSRIILTLSSLVTFSLLNILMYHLYDTPFLQHTFLHHLTRIDHRHNFSPYSTLLYLS
                     AAGEVQGNFESLAFIPQLLLSVVVIPLVLAKKSLPGAMLAQTFAFVTFNKVCTSQYFLW
                     YLIFLPFYLPRSSMLKAPRFGGAVAAAWVVGQALWLQQGYNLEFLGLSSFVSGLFLASL
                     GFFAVNVWILGIIVEDVGAC"
     mRNA            complement(join(12252..13250,13298..14425))
                     /locus_tag="KYF_008971"
                     /product="hypothetical protein"
     gene            complement(12252..14425)
                     /locus_tag="KYF_008971"
     CDS             complement(join(12252..13250,13298..14425))
                     /codon_start=1
                     /db_xref="InterPro:IPR007219"
                     /db_xref="PFAM:PF04082"
                     /locus_tag="KYF_008971"
                     /note="EggNog:ENOG41; antiSMASH:Cluster_66; GO_component:
                     GO:0005634 - nucleus [Evidence IEA]; GO_function:
                     GO:0003677 - DNA binding [Evidence IEA]; GO_function:
                     GO:0008270 - zinc ion binding [Evidence IEA]; GO_process:
                     GO:0006351 - transcription, DNA-templated [Evidence IEA]"
                     /product="hypothetical protein"
                     /protein_id="ncbi_KYF_008971-T1"
                     /transl_table=1
                     /translation="MYRSSRHVEKLSTTLDEFRGVLDKLFPGIPAETLVNLPRDKLLEL
                     TGKGPSQMQTQAPHPASPATSASVEAHASPASSEDGNLESLQTIPDHTTDDRELKGSEL
                     TSTVSDDVNALSLSAKQPSSYLGVSSIHAVLKVIVWLEPSSLSHLSRAPATGVRRESVM
                     DIASPEAQAWQVFGSQPHHGTSTHSPLQVPETQLLDAYFTYFQPFVPMLDEQYFRQTYL
                     SARRKDKQWLALLNIVFALGSIAATPADDMSHQAYYMRSMSHLNLESLGSPHVETIQAL
                     GLMGGYYLHYSSQPNLAYSMMGAALRMAAALGLHKEVSDGQYGNGRNKLSSVDHKRRVW
                     WSLFCLDTWGGMTLGRPSMGRLGPAITVKLPHYRETGNVLDLLPLLENVRFCKIATQIQ
                     EVLAVAPLTKHHEMAHLDSQLLEWYDNLPYILKDHEPCSESIAITRTVMKWRYYNQRML
                     LYRPTLLSYAMRRVPYIVLRSEERTAIERCREIAEATIQDVAAKAQYHQMSGWNAVWLI
                     FQAAMVPLLGLFLNDGTVDDPRATAEACQAQVETTMLVLERLEPWSPAAKSTLEAVSRI
                     FEAGKRGPSVIGEAHSINSGSCVTSTEETLGAVPGVSPMQVDFGRAIPHDSGFVDPFEP
                     QFINDSAGQYLWDFLSWSDSNLLQGLADIDNVNNGALFPQEERNAKYGSSDPSFFGGQL
                     GDSTFFINSEPSFY"
ORIGIN
        1 atgaaagtga gaacgtgtat agaccgagga taggaaatag ttattgggat agaaacccat
       61 caagggatca agtgagttgc ggtgaaaggg gccactggag actagccgga ttaggcgggg
      121 ggatgttttg cacccaaaca ttaattatcc ttctttcttc tcaggtgttg ttgacaacaa
      181 attcaacgca ccgcatcgtc atcccacccg gttttcttct cgcctcattt tttccctccc
      241 ttccagcctc ggccgtttcc tctcctcatc tggacggtca agaacccgct gtcgactggc
      301 tggtgccatc atcatgcttg cagattctcg agcactgtcg caatgccatg agccgctctc
      361 ctttccgccc ctcgactccc gcaactatga acgccgccga taaacaaaac aatggccatc
      421 tcgccaaacc actcaccccc gccctcagcg ccgcctttca tcgctcccag aaatcccctc
      481 tgactcctcg actcgctact cccgggggtt atcgaactcc caagcgactg gccgcctccg
      541 aacatccctc gtccgccccc tccaagcggg atcccgagcc atcatcatca tccctgctca
      601 gtgccaacgt tacccctcga tccggctccc gcaacagcag acgcgatggt gctgtttcct
      661 cccccaacaa caacaacacc ccgaccaacg ggcaacagtc gccccaggtg acctggacac
      721 aaccgcatgt gggccagctg tcaaatacgg ggcgactccg gacggagcgg agtcccgttc
      781 ggggggcaat gctggaacca tcgcggacaa cccgggccag gaccgtgacg atggagtcca
      841 accatctttc ccggcctaat tctgcgtcgg ataattcagc cggggccccc atgttttttc
      901 acgcctccga tgcacgatcg accatttccg agcaggagcc ccgcccgaag ctgcagacaa
      961 aaacgtccgg taccactttt atctacgcaa acggggcgca agagaggcag tccccggtaa
     1021 gtgaggtggg gggtacgtat aaacgccggt cgattggctt gacgcgatcg gtggtgtccg
     1081 cgaaaccgtc tgcctcgcca cggctgcgac cagcccgggt ggactcgaat ccgcggctgt
     1141 ctgatgggcc gtctgtagtc gggtcgcagg atgactcgtt tgaagcaggg tcacaggctc
     1201 atagtccacc catgagcagc gtatcagcgc gaccgattcc agccgtgcga cacgttaaat
     1261 cgtcgagtct cgactctggc cacagtggac tctcgcctcc tcagaaggaa ggtctgcggc
     1321 caagtccgct gatcatatcg ccatcagaac caaagatcga tgctagcacg attgcatccg
     1381 aaccgctgcc aggtctccgg ccgcgagtgt tcagcaatgg gtccatcgct tcagtggata
     1441 cgcataactc ggggatgcag agcccgtcca agtcagaaag cggacaggct aacggcgccc
     1501 ttaatgcgcg tacggagcgg aagatcatgg atcttgaaat cagcaactca tcgcttctcg
     1561 ccatcaaccg cacgctagaa cgggagatgc ggaagcagaa cgccgagctg cggagatacc
     1621 gacgcctcag tcgctcaggg cgtctatcca tggcgacgtc cagccggtcc gtgtccggcg
     1681 ctctctcgat tcctccggaa gttgaggaag caagcgagca ctcatcggtg cggtcgccag
     1741 aagaactttc cgactttagc gacgaagact ccttggaaga cggggtgctg agcccggact
     1801 cgcaggcaga tcaggactcc cagcatcgtg cgcgggatga gaaacggttc ctcatcgacc
     1861 tggcgaagca tcaggagctt cttgccgaca gccagcggct gaaccagagc ctcaagcggt
     1921 gtctaggatg gactgaggaa ttgattaggg agggacagcg cgcactcgaa tacaatgtcc
     1981 atgtaaacga cgtgcaactg ggtggacgcg tgctcacccc ggaggagctg aatgagctga
     2041 acgagctcaa cgagctgcac gagcagcaag aactcgagga tatttctcgt ccatcaagtc
     2101 ggagcgactc cgaaccgcct tccgaggacg gcagctagct gcattgcata ctactatctc
     2161 atctagacta atacggcgtc gctggtgtac tgtgctattt gttctgaccg actaaagctg
     2221 gcatttagtc ttagcttttc cttatgcgtt ttgaattgtt tgattgtttg atcgtgttga
     2281 tggcgataga tggccggccg gcagctgttc tgagctagat acccatacgc gtgaattttt
     2341 tctagcatat accatactat ataccatata ccacttttgc atgcatccac accctcactt
     2401 ctctccagac aacataaaaa ccacgaaagt agtaatccta aggccttcca tccccaacct
     2461 ggcccccacc actgcccgcc ccctcaatac acgcctcctc gaatcccgcc aactcctgca
     2521 tctccttcac accccccagg aacccctcca aagagcaaaa cccattccct ccatccgact
     2581 cacacccaga caccccatcc accggcacgg gcatctcatt caacacccac cgcacatact
     2641 ccttcccgac cccctcacta accgtcggat tctcataaac cacctcccca cccgcatcca
     2701 cctcaatatc cgcagcagag gaagaatcac acctccaaat ctccgtcaca aaccgcgccc
     2761 cgaacggcgc aatcctattc aaccggaacg tgcgattcag agggacctcg ttcgcactga
     2821 tattcccttt cattccatcc ttcccgatat tgaagtactc cacacccagc gcagccaaca
     2881 cagacacgat cacgtcgtcg tgagacatat ccaggtagag tggttgatgc agcgggaatg
     2941 tgctcgggtt cgagtcgtac gtaatgttga cgttcgcaac ctgcttctcg atcaccttgc
     3001 cctgaagacg agatgctagt tcgaggacgt agccgatccc ctgggccctt ccggagggag
     3061 agccgaagcc gtagtccccg tagaactgca gatcgaggat ataagcgtag gattcccatt
     3121 cggagggggt gaagagcgcg cagaaggagg aggtgccgag cacggcggtc tcgtatgcgc
     3181 agaggttttg catggagagg atgtccagat aggttaggtt tagggttgag gggaggtact
     3241 gggagaagcg ggtgatgatg gggggtgtgt agatcttgag gaattgctcg gcggagtcgt
     3301 ctctattttt atcattagta ggtgggcaat ttgggtataa gagggatggg ggatatgcgt
     3361 tacccctctg aagtatcccc gttaggacag cttcctgaca aggtattgtt gtagccgtcg
     3421 ccctctggaa tgatcaccag gtcgtagtca tcggaggagc tgttggctgc gatgttgctg
     3481 aagaagccgc ctatacgtct tattagcatt cttctttcat ctactagggg aattgaattg
     3541 aattgaaaga attagagaaa gagccggggg ggagacatac tcaaccacca cctcgcactc
     3601 tccaagatcc tcgcctgcga tgtcgtccta aacatgggct tgctcctcct cgttccattc
     3661 ggaaacacat tcaactcgtt actccagtcg gccatgcccg ccggggcatc atacaataca
     3721 cgtccgtacc gggaccagtg gaatgcaccc gaggtagctt ccgtcgctgc gccggtgggg
     3781 agaagggcct ctgtgcccat gaggtatctc cagttattga ggaaagaaag agggccagtg
     3841 gcgagggtgc tgtttgggtg tgcttgagtg tagttcttta gcttctgggc gaaggattcc
     3901 atgctgtcgg cgtcgaggag gtaggaggtg ggatagcgtt gcgcgtgccg gtggaggatg
     3961 tgcgcttggg ttagttggca ggtcttgggc gtgcccgggg ggatgccgaa gcctgggctc
     4021 gaggtgtagg gggataggtt gccccatgtt gagtggaggt tgaagggggt ggtggtggtg
     4081 gtgtttgttg cggtggtgag ggttaggagg cacaggagtg ccgttgtgag gggggagagg
     4141 aggatcatga tggttacggt gtggggggtg gctacatggg gagagggatg gtagaagggg
     4201 gggggaagag gtgaggtggt tatatatggg agagttcagt gcggaataat tatttggatt
     4261 gtatctatgc tagaactgag tgggaattga gcggagtccg tcgtatcaat gctggccagc
     4321 ctgctatgtg tggtgcgggg gggctggttt gctaaattgt taggttggta ggaaagaagt
     4381 agtagatagg caagtattgc ggagtcgaag ctttagaccg gctcaagtct aggagaaatc
     4441 tgctaacgga tccaggttac gcagtggtgc tactgaccag atagtgatag tgtggtggtg
     4501 aagtccatgg agcgggaaag ccttccgttg ctgattgtgg taattggtcg cgtgaggttg
     4561 gagagagaga cggagagaga ccgccaatcc tgccaaagcg gggttggaga gcagcagaga
     4621 gccggtaaga tggaatccct cctggcagta ggaaagctta tcagaaggtg agacacggcg
     4681 ggacgggttc ggtagtttct atctccagtt tttttgagag gggcgccggt gaatgttagg
     4741 ggtaggacct gcttcccagg ttatatactg attactagta caacaatgta ggtaggcaat
     4801 cattgttgtg agttgagata aggaacagta gagctgctta tgagtggcac gtaagatatc
     4861 ccattgactg atgaaatagt actacttttc ttcctgcatg cagttttctg tctgtctcac
     4921 cccgcagcca ctaccgctac acctgcaggg ttagttggcg gttgtacctt ctatcgtacg
     4981 acgtcactta ctccgcatgt aaccaaaatt ccttggaagt cggcgatatc cggttcagta
     5041 acggatcatg agttggtatt agtcgcagta gtagttagtg gttggtgctg attaaccgga
     5101 gcacaggaga ccgttacggc cgagatatat tctgtcggaa ggtgaactta gtaccaccac
     5161 taatagtagt aatcgtctca gccctacggg gcaccaccgc cagcagcagc agcagtagtg
     5221 agtggtaaat gctgcgacag taatcactat aatgacctac cagtagtaac atgaatctaa
     5281 ttgatattca ttctgcttac atctattacg catctggcag ggtatgccgg gtcgctactc
     5341 aacatatatc caatgtccag tctgaaccac aaaaacaaaa atagactatg caaggtatct
     5401 aggcagtggc tgtgggctct tcgtggtggt gctcgtgctt cttcttcttc ttcttgtcct
     5461 ccttaccctt cttcgtcatc gactccgcca tcagctgctc gaacgccatg aagtcaccct
     5521 cctcatcagg atcgcgctca gcctgacaca gttagcatac atccagaccc ctgtagtgaa
     5581 tcccattgta gtgaacggtg aacatacctt ggagtaaatg ttacccgcaa tcaccagagc
     5641 atgagcacgc tcaacgcgct tgtccagctt gatgcgcttg tctccgagca cctggtcgca
     5701 cacatcacgc agcacgctct ggatctcaaa cttgctgccc cgccatgctg ccgccaagat
     5761 cttgcccgtc accttcttct cgtactcggc cttcttctca tccgtccagt cctcgccacc
     5821 gcgctcctcc agcttagcca tctcctccat ggtcatctgc gcatcaatgg cagtggaaat
     5881 ggtggtccag gtctccttgg ccagcgtgcc cttgtccttc agccgcgaga agaatccgga
     5941 aatacccagg aacttctgcg acttcaggaa agaggtggcc ttctgcacat aggtggcgcc
     6001 gatggcgtgc aagatctcca aaccgaacga ctccatcttc aggttctcca cctccagccg
     6061 gatcttctcc tcgaacgcgc gggtcatatc agggctcttg tcggtttccg tccacacgct
     6121 gatcttgtcc accaacttcg tggccagagt gttgacccgc tcctcgcgcg ccttcttgcg
     6181 ctccaactcg tacgccgcca gacgctcctg ttgctctcgg gacaaaccac ccttcttctt
     6241 ctccttcttg cgcagctcct tctcctcctg ggacagacca gctgcctcca tgcgcgcctc
     6301 ttcctccgac ttgtccatga tggcctgttg gcccatgtag cggcgggggg tgctcgtgcc
     6361 ggagctcggg gatgcggcgg cagcgggctt ctcggaagcg gcggtcgtcg actcggcggg
     6421 ggtagcttgg gcagcacctt cggtagtgcc ttcagcagcg tgcgcctggg tctcgtcgtg
     6481 gatgttgagc ttctcctcag cggatgcggc cagttcttcc tcctccatct gctgcatggt
     6541 gatgtccatc gtagtggtga ggtccttcat gagcgagatt tcaccgatga ggtcgacaaa
     6601 ggcgttgcca ccgaagatca tgccaaagaa ctccgagggg tcctctgtag ggcattagta
     6661 tccgactgat tgcctgcgag atgcaatgtc ttaccaaaac ctccaccggg aacagcatcc
     6721 tcctttccaa acttatcgta gcgcttgcga agttcttcat cgctcagaac ctgataggct
     6781 tcaccgatct gtcatagtag agagtgtgtg tgagcgcatg attttgagag cagacaaaca
     6841 aacagtatct acccacctcc tggaatcgcg catgcgcagt ctcatcaccg gggttcttat
     6901 ctacgacgat cagtagtggt caaccagagg acagcgtgcc acgcacccgg atggtggata
     6961 atggccagtt tgcggtaagc cttcttgatc tcgagttcgg tcgcggtggg cggcaccccg
     7021 agggcgtcgt agtaggaagt gtcggcaacc atggcgggcg atgtgagcag gacccaacca
     7081 cgcaatcaat ctagcggtca ccgatgcaga aaaatcaagg ccagccggca ggcgtgtgac
     7141 agaaatagaa ggtgatcggg aataggatgt gctggtagcg acaacaggat cagatgtgtc
     7201 tcctgtgatt ttttctgcct aaacgatgtt attttggctt ttagttttcc gctggatttc
     7261 ttccgtcatg gcggggagag aggcagacag tcacttgcaa tggggggatg gcctgaggcg
     7321 ggcaggcagc cagtgcggtt gtcacgtatg gtcatcaagt ggtcacattc cacacagata
     7381 gcacggaata catgcatcga tccatgtaat ttgccgtaat accgagttat gcgcccgcac
     7441 gcgctcagcc gccagcccag agccgctagc cgcgccgcct tccaagcggg cctttaaaat
     7501 tttccttctt tcgctttctt ttcttctttt tcttcccttt tcctcttcgt cttctgttta
     7561 ttcctcttct ccctcctctt ctcctctctc ctcccctgat tttccctctc ctcccaattg
     7621 tttacttatt tcctcttcct ctacatctct ctctctctct cacccccctc tccttcctcc
     7681 tcctccctcc tactcctaca ttcctctgtc tgcttgactg gattccccgt ctcctccccg
     7741 ctcatcctcc ccagccagtg aggcattcac tcgctgtgct tgtacattat tgtaccatcc
     7801 tatccctttc ttttcctctc gaattccgtt gattcggtca ttctcccgca ttgcttccct
     7861 ctgctttcca ttccctttct tattacgtgt aataattccc cattttaccc taattcttct
     7921 attccgtcat ttttgaccgt tcgatcgtaa tctaccctcc accatgggtc tcgcatcgaa
     7981 tgccatctac tacacgtttc atccctcgga actgaggtcg attttgcaat ggttggttcc
     8041 ggcccttgtc ctcgaccggt tatgatgggg tttagtgtgt tgtgccaacg cttacgaagg
     8101 ctttgcccgt ggtcatagga agatctggca ctccccggtt catgagcgca atgagaagaa
     8161 cgaaaccgag actgagaagg cctgcttcaa attcctcgac ctgaccagtc ggagcttcag
     8221 cgccgtcatc aaggagctcc acccagagct gttgatgccc gtctgcgtct tctacctcac
     8281 acttcgcggg ctggacacca tcgaagatga cacgtcgatt gctttggaaa caaaggaacc
     8341 cctgctgcgt ggcttcaagg acttcctgga acaggatggc tggacgttca atggcaaccg
     8401 ccccgaagag aaggaccgtg agctgctggt tcagtttcac aatgtcatca ccgagttcaa
     8461 gaagatgaag cccgcctacc aggccatcat caaggacatc actgacaaga tgggcaacgg
     8521 tatggccgat tactgtcgca aggcggcctt cgatgacgcc agcgtgatca ccgtcgagga
     8581 atacgacctg tactgctact acgtcgccgg cttggttggt gaaggactga cgcgcctctt
     8641 cgtcgaggcc gagtttggta accctgccct gctggaacgc gcgcgtctgc acaagtccat
     8701 gggactcttc ctccaaaaga caaacatcat ccgagacatc cgagaggacg acgatgatgg
     8761 acgtcgcttc tggcccaaag agatttggtc caagcacgtc aagcagttcg atgatctgtt
     8821 caagcccgag caccgcgaag ctgcactgaa ctgcagctcc gagatggtgt tgaacgcttt
     8881 ggaacatgtt gaagactgcc tgttttacct ggctggcctg cgtgagcaga gtgtgttcaa
     8941 cttctgcgcg atcccgcaat ccatggccat tgccacgctg gagctctgct tccgcaaccc
     9001 tgcgatcttc gagcgtaaca tcaagatcac caagggtgag gcttgccagc tgatgttcga
     9061 gtcgacgcag aacctgcgta tcctctgtgc tgccttccgc aagtacgcgc gcaagattca
     9121 caagaagaac acacccaagg accctaactt cctcaaggtc agccttgttt gtggacgggt
     9181 atgttttttt ccccccttct gctctggttg ggctacgcta atgattatag attgaaaaat
     9241 ggatcgagac catcttccca tctcagaatg ccgaggccgc taagcgtcgt gtcactggcg
     9301 agctgacgga acaggagaag aagcaggccg aggagcacgc cgagactcgg aaggacatgt
     9361 actttatgat gggtctcatg gtggtgattg tgttcatcac ctcggtcgtt atggtatgta
     9421 ccttcacctg acatctaatt gaatttggct aacccgaata gatcttcact gcctggctac
     9481 tgggtgcgcg attcgacttg gcgtggcagg agctgcggtc cggcaacttc cggccaccaa
     9541 gagaaatccg ccaaaagcaa gagctgtaat gcattctacg gagttatgac tgattgatct
     9601 actagctgcg gaggcttatg tcttatacct ttctgcccac cgcttattta ctaatacatt
     9661 acccttcttt cttcttcctt tcttaggtct atatttctgg acgatgaact agcacggatg
     9721 tcaaattgcg atccagtctt tccatgactg tggttgtgcc gaagaagtgc tgatattgag
     9781 ctgaatattc tgaccagcga cgtactagat gtgtgtctta caacttaagt gttgaggtgg
     9841 caaacatcca ttgaggacct ggaacaaatg tagtcatgta accatgaatt tacatattac
     9901 cacttgaaca atatgacttt cgtttgataa acatcttttt ctctaaaccc atctcgtaga
     9961 tctgacatag tcttaaggag cattctactg tactcaaccc caatccaata cttccacata
    10021 tcacacaata atccctaact aattacacca catctcccct ccaacacaac acaaccctca
    10081 acacttaata cataacatac ataaaaaccc cccaactaac aagccccaac atcctccaca
    10141 ataatcccca aaatccaaac attcaccgca aagaacccca gcgaagccaa aaacaaccca
    10201 gacacaaagc tactcaaccc caaaaactca agattatacc cttgttgcaa ccacagcgcc
    10261 tgtcacccaa ccaatcagtt acacatccca tacgtaacat acaaaagtta agccaaaagg
    10321 agagagagag agagaaacac atacctgccc aacaacccac gccgccgcaa ctgccccccc
    10381 aaaccgcgga gctttcagca tcgaagaacg gggtagatag aatggtagga agataaggta
    10441 ccacagaaaa tactaccatc cctatcagcc catcccattc caaataattt atgggcaggg
    10501 ggatcaagat aggggtaact aacctgactc gtgcaaacct tattaaacgt cacaaacgca
    10561 aacgtctgcg caagcatcgc cccaggcaaa ctcttcttcg ccagcacaag cggaatgacc
    10621 acaacagaga ggagtaactg cgggatgaac gccaacgact caaaattccc ctgcacctcg
    10681 cccgcagcag agagatagag gagggtgctg taaggcgaga agttatggcg gtggtcgatg
    10741 cgagtaagat ggtggaggaa ggtgtgttgc aggaaggggg tatcgtagag gtggtacatg
    10801 aggatattaa ggagggagaa ggtgacgagg gaggagaggg ttaggatgat gcgggaggga
    10861 gtgatgaagt tgatcgtctt cgtgatgata ttggcatcgc cagcattgtt cttagatgtg
    10921 ctgctgctgc tgctgccatc acgttcccga tccagccacc aaagaatcga taccccgtag
    10981 ataaacggat agatcttgaa atgcacactc aaacccagca gcacacctgc aagaacgacc
    11041 ctcctgcgga gaacagccca cagcagggca atcaccagca caccgagcag tccttccgag
    11101 gaccctcggg tgctaatgtt cgcgaccatg gggttgagta gccagaagct agcgtacttc
    11161 agagcgcggg gagcgtccat tccgtacgcg gaaacgaggg atctggcgat gagccatccg
    11221 gcgaggacgt cggagagggc gaagagggct tttccaaagg agaagaggaa agatgggccc
    11281 gaccaggagg tcgggaggag cagccatgct aggagaggcg tgtagcggta agtgtctcgt
    11341 tcgtagggcg aggcgccgtg cgagacgtag cgggctgcgt cggtgaagac gaggtagtcg
    11401 atgtcggtgt atttgacggc ggagttggcg tcttgccagg cgccgtagat gaggaggatg
    11461 gcgcggagag ctatggcgga ggtgtagact agggaggggg tttggaagaa ggacgccatt
    11521 ttggatggca ttttgatgta gagggaaggt cgtgttgtgg ctacttcatc ggtgatagct
    11581 tactcctgat agtagctccg caatgaagcc ttcgacgacc gggcggatcg tctttggatg
    11641 ccagggcaat ttagtagtgg ctagtatgta cagatccggc tgatctcacc atcctatgtc
    11701 tatttggtgg gcaccgtggg ttctggttgg ttagatgaag ctatcccgga cgcgaggaaa
    11761 cgtgaccgga tcggtggctg agtcagcagc gagatgatct tgcccgatta ggatgaaact
    11821 gtgtactcga agatgagaag aaattcggaa tattttcttt ctttcggtta tgccttagct
    11881 ttcttgtcta agatattgaa ctaggtggtt ttatccgaga cgtatctttt acagtctcag
    11941 ttcatagtga ggaggcgctc acccatatca taacctactg ggtaaccata gctagtttga
    12001 atacacattg tagatcaaaa atatattgct gaagcagttc tttttgctat cgtgataccg
    12061 tgttctcgac ataaatcctc cgaatcctcc gaatcgcccg taaatgcatc aatcataaat
    12121 aattctgtaa tgtggagatc gctaacatat ggcggggaac gacaaaacaa acatagagcg
    12181 agtgaataat agaacaccat gtgacagaag tgaacaccgg cagcgatgag gctgcaccct
    12241 gtaagtacag cctagtagaa ggacggctct gaattgataa aaaatgttga atctcccaat
    12301 tggcctccaa aaaacgaggg gtcgctggat ccatactttg catttctctc ctcctgggga
    12361 aacagtgctc cattgttgac attgtcaata tcagccaaac cctgcaacaa gttgctatcg
    12421 ctccaactaa gaaagtccca aagatactgt ccagcagaat cattgataaa ctggggttca
    12481 aatgggtcga caaatccact gtcgtgtgga atagcgcgac caaagtcgac ttgcatcgga
    12541 gataccccag gaactgcgcc aagagtctct tcagtagacg ttacacagct accgctgtta
    12601 atgctgtggg cttccccgat gacgctgggg ccacgtttac cagcctcaaa gattcgggaa
    12661 acagcctcga gcgttgattt ggcggctgga ctccaaggtt ccaagcgctc caggacaagc
    12721 attgtggttt ccacttgagc ctggcacgct tcagctgtcg ctcttggatc gtcaaccgta
    12781 ccatcattga gaaacaagcc tagaagaggg accatagcag cctggaagat aagccatact
    12841 gcgttccagc ctgacatctg atggtattgt gccttggcgg ctacatcttg tatggtagcc
    12901 tcggcaatct ccctacatct ttcaattgcc gtcctttctt cagacctgag cacaatgtat
    12961 ggtacgcggc gcatggcata gctgagcagg gtggggcgat acaagagcat gcgttggttg
    13021 taatagcgcc acttcatcac ggttctcgtg atcgcaatcg actcggagca tggctcatgg
    13081 tctttaagaa tatagggaag gttatcatac cattccaaaa gctggctatc aagatgtgcc
    13141 atttcgtgat gttttgtcag cggtgccacg gccaggacct cctgtatctg tgtcgcgatc
    13201 ttgcaaaagc gaacattttc caaaagcggt agaaggtcga gcacattgcc ctaagtatgt
    13261 cagttagatc cattacagca cacaatgtat cacataccgt ttctctgtaa tgtggtagct
    13321 taacggtgat tgctggaccc agccgaccca tgcttggccg tcccaaggtc atgccacccc
    13381 acgtatccag acagaaaaga gaccaccata cccgacgttt atgatcaact gaagatagct
    13441 tattcctgcc attgccatac tggccatctg acacttcctt atgtagcccc agagcagccg
    13501 ccatgcgcaa cgcggctccc atcatggagt acgcgaggtt gggttggctg ctatagtgaa
    13561 ggtaatagcc acccatgagg cccagagctt ggatagtctc cacgtgtggt gatccaaggc
    13621 tttctaaatt cagatggctc atagaccgca tataatatgc ttgatgggac atatcgtcgg
    13681 ccggggtggc tgctatgctg cccaaagcaa agacaatgtt aagtaacgcg agccattgct
    13741 tgtctttcct gcgcgcagaa agatacgttt ggcgaaaata ttgttcgtcc agcattggaa
    13801 caaaaggttg gaagtaggtg aagtaagcat cgagcagttg agtctcggga acctggagtg
    13861 ggctatgggt ggacgtgcca tgatggggct gtgacccaaa aacctgccag gcctgggcct
    13921 ctggagatgc aatgtccatg acagattctc gacggactcc tgtggcgggt gcgcgagaca
    13981 aatgagagag agagctcggc tccagccata ctattacctt tagcacagca tggatggaag
    14041 agacacccaa ataggaagat ggctgtttgg ccgagagaga taaagcgtta acgtcgtcgg
    14101 atacggtact cgtaagctca gaacctttca attcacgatc atcagttgtg tgatcaggta
    14161 ttgtctgtaa agactcgaga ttgccgtctt cgctggatgc tggcgatgcg tgagcctcta
    14221 ccgatgccga ggttgctggg gatgccgggt gtggcgcttg cgtctgcatc tgggaaggcc
    14281 ccttgcctgt cagctccaga agcttgtccc gaggcaagtt gaccagggtc tccgctggaa
    14341 tgccagggaa gagcttgtca agcactcccc tgaattcatc gagtgtggtc gacagtttct
    14401 ccacatgcct gcttgatcga tacat
//
