LOCUS       ch7                    17234 bp    DNA     linear   PLN 26-AUG-2019
DEFINITION  Aspergillus niger.
ACCESSION   ch7
VERSION     ch7
KEYWORDS    .
SOURCE      Aspergillus niger
  ORGANISM  Aspergillus niger
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Eurotiomycetes; Eurotiomycetidae; Eurotiales; Aspergillaceae;
            Aspergillus.
COMMENT     'Annotated using funannotate v1.6.0-df4262f'.
            ##antiSMASH-Data-START##
            Version      :: 5.0.0
            Run date     :: 2020-11-03 01:15:18
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 2551624
            Orig. end    :: 2568858
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             join(1..7,134..913,994..2054,2147..2287)
                     /codon_start=1
                     /db_xref="InterPro:IPR007219"
                     /db_xref="PFAM:PF04082"
                     /locus_tag="KYF_009535"
                     /note="EggNog:ENOG41; antiSMASH:Cluster_70; GO_component:
                     GO:0005634 - nucleus [Evidence IEA]; GO_function:
                     GO:0003677 - DNA binding [Evidence IEA]; GO_function:
                     GO:0008270 - zinc ion binding [Evidence IEA]; GO_process:
                     GO:0006351 - transcription, DNA-templated [Evidence IEA]"
                     /product="hypothetical protein"
                     /protein_id="ncbi_KYF_009535-T1"
                     /transl_table=1
                     /translation="MTCRPCQYKRKFKKRGRKAAVNHKSPLPAEAHCDLDVPSTPSSGG
                     IHPTSFGPARDEASIDGVPAVSGFLAMGRELPESHEPVNMNNVEATFGTYQANIPRSFD
                     LSQPESGATALSPIPRFPTLALTPRDASATSASSTSLPAGCRFPCLEPLLPHLKSVLSP
                     EDACSLLEIFFTEPGESAGSSHSPYVLSPVLRRSAVLDPIKPRPTSPALLATMLWCAAH
                     TANGRLYYIPGSRARIVDHLYCLVMSLLQRLDPDNWRRVNGGWQLENDCVSALDAGDPD
                     RARRTFGTGPTPTVDDVLTFVILTIVISGGEYKSDCLKWWNKALRLIKHLGFHQDPLRT
                     GQPERGSLQIIEEQEEKRRAFWLVYALDRHLAVSHNRAVYLIDAECEVLTPLPESCWQR
                     LHAFTADTLPSRTYGPPTVISGTGLFEYFLPLMSILGDIIELRLWRHHPRLKFDEHAVV
                     SAIDIALTNCHQSVSEWLREVGQTANASRPFSTTPRAEVTMAYASYIIKVLFVMLYGEW
                     DATSMLENHGDWITSAQFSECASHSIAAAQQISYVLSIDPELSFMPYLVGIYLFHGSLV
                     LLLFAERMPLVGPNPSVEEACEVIIRAHEASIVTLSTDFQKAFRKAFRSVLLHSRAQGE
                     VNTELRALRQDILSMYRWTLGDPGLCL"
     protocluster    1..17234
                     /aStool="rule-based-clusters"
                     /contig_edge="False"
                     /core_location="join{[2559605:2559754](+),
                     [2559811:2559935](+), [2559985:2560004](+),
                     [2560062:2560239](+), [2560313:2560470](+),
                     [2560518:2560608](+), [2560657:2560691](+),
                     [2560750:2560974](+), [2561031:2561101](+)}"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      join(7982..8130,8188..8311,8362..8380,8439..8615,
                     8690..8846,8895..8984,9034..9067,9127..9350,9408..9477)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     cand_cluster    1..17234
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..17234
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="9"
                     /rules="(Terpene_synth or Terpene_synth_C or phytoene_synt
                     or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps
                     or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /tool="antismash"
     mRNA            join(1..7,134..913,994..2054,2147..2287)
                     /locus_tag="KYF_009535"
                     /product="hypothetical protein"
     gene            1..2287
                     /locus_tag="KYF_009535"
     mRNA            3495..4574
                     /locus_tag="KYF_009536"
                     /product="hypothetical protein"
     gene            3495..4574
                     /locus_tag="KYF_009536"
     CDS             3495..4574
                     /codon_start=1
                     /db_xref="InterPro:IPR023210"
                     /db_xref="InterPro:IPR036812"
                     /db_xref="PFAM:PF00248"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039:aldo/keto reductase family oxidoreductase (Score:
                     122.3; E-value: 3.5e-37)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="KYF_009536"
                     /note="antiSMASH:Cluster_70"
                     /product="hypothetical protein"
                     /protein_id="ncbi_KYF_009536-T1"
                     /transl_table=1
                     /translation="MFESNPLHPTLTLPPIILGGSGFSEQSHPNPQTLPVATIIRRAFD
                     EGILAIDTSPYYHPSEHLLGTALSDPQITTRYTRSDYILMTKVGRLSTSVFDYSPTWVR
                     QSVHNSLERLRTTYLDVVFCHDVEFVSEHEAVQAVGVLFDLRQQGYIKYVGISGYPLET
                     LVSVAHAVRHVYGQPLDVVQTWAQLTVQNTKLERYGIPALREAGVSVVCNSSPLASGLL
                     RAGKVPCGRLGDWHPAPEGLRSAVSIASGWLECQGFGLAGLALRFSLAKAVRAADRYAV
                     SVSTVLGVSSLKDVEEDVEVARDILRDLDAGLVYKRMEVMGGLSRLRWVNEEVECRDLR
                     LCYGVRNILGEWAEYDLQK"
     mRNA            complement(join(5375..5830,5891..6183,6239..6353,
                     6418..7254))
                     /locus_tag="KYF_009537"
                     /product="hypothetical protein"
     gene            complement(5375..7254)
                     /locus_tag="KYF_009537"
     CDS             complement(join(5375..5830,5891..6183,6239..6353,
                     6418..7254))
                     /codon_start=1
                     /db_xref="InterPro:IPR008930"
                     /locus_tag="KYF_009537"
                     /note="EggNog:ENOG41; antiSMASH:Cluster_70"
                     /product="hypothetical protein"
                     /protein_id="ncbi_KYF_009537-T1"
                     /transl_table=1
                     /translation="MSSSILVQCAKDLIAKVASESKSQYGFSSMAPSIYDTAWLAMVEK
                     RTDQGYEWLFPSSFEYLLREQTNDGGWDALESVARQHSGYPENIWIQDCVIHSLAALLA
                     LCRHVRRSSSHHREPLPDDILFRLFSAKSFLDAKLQKWQPDDGIHLTVELIVPVLLHLL
                     REEGVDFQFPAKDDLLSKFTAATSVDLSWLYQGPCSIPLFSLEGFASQLEWDKLECLVT
                     SSGITASPASAAAYLIFSPNWSDKCEAYLRHIVSHGQGKGSGGAGGVYPLEVFEPCWVL
                     STLLDSGFTVENLGAQNVGELVELIHRSISNGVTGATHTFFPDADDTARALMVLNNNGY
                     AVSRANLIRKFECDDGFETFDDRMPQRVTSVSVNGNVLSCLLSSSDPSAFTPQIENFAK
                     FMCTKWSKEKTLHDHWNLSEYYGIMHIAQSLVPVRVLWDQGCIPGLAEDIVEKHISTCL
                     REVVDRVLRGQNDDGSWGNMHGAEETAYAIIALAQLASHADIVSDYSKADLAIARGKQF
                     LLETWTMGQKPDRIWTGKVLHGISYVHDAHVLAALKINRANLAGKRGFF"
     mRNA            join(7982..8130,8188..8311,8362..8380,8439..8615,
                     8690..8846,8895..8984,9034..9067,9127..9350,9408..9477)
                     /locus_tag="KYF_009538"
                     /product="terpene cyclase"
     gene            7982..9477
                     /locus_tag="KYF_009538"
     CDS             join(7982..8130,8188..8311,8362..8380,8439..8615,
                     8690..8846,8895..8984,9034..9067,9127..9350,9408..9477)
                     /codon_start=1
                     /db_xref="InterPro:IPR008949"
                     /db_xref="InterPro:IPR034686"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: Terpene_synth_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052:Terpene synthase/cyclase metal-binding domain
                     protein (Score: 154.6; E-value: 6.6e-47)"
                     /gene_kind="biosynthetic"
                     /locus_tag="KYF_009538"
                     /note="EggNog:ENOG41; antiSMASH:Cluster_70"
                     /product="terpene cyclase"
                     /protein_id="ncbi_KYF_009538-T1"
                     /sec_met_domain="Terpene_synth_C (E-value: 5.1e-13,
                     bitscore: 45.4, seeds: 87, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MEQRQELCDSLKGQYAVLPNLYSLFPDWSPELHPEYTRARDESTN
                     PWIKRFAKNPLVCRKLQEADFTTFAAVMCAKSSFEQLCTVAKWFTWYFIWDDLFDCGSL
                     SHDSKTIKRYKHTSIEYFKHVLCHEAAYPDLSEFSEELQNALRCWDEIAEHVLTRKVLL
                     AAMIDYLSSVDGVDSIYSEGEIPSVQQYWRRRDRTAGVHPVIATIPFIYDFDISARDMD
                     DTHMKLLRRHTSYLVHIQNDMFSLRKEVRVGQVENLVPIIMLNENLRASQAMKVAFMFA
                     QESARGFDEVVDDMRQTAKGRRRAVADIFIKGCRNIVMGLTHWSYTGERYFRAGEADEN
                     HTIYFEL"
     mRNA            12687..14753
                     /locus_tag="KYF_009539"
                     /product="hypothetical protein"
     gene            12687..14753
                     /locus_tag="KYF_009539"
     CDS             12687..14753
                     /codon_start=1
                     /locus_tag="KYF_009539"
                     /note="EggNog:ENOG41; antiSMASH:Cluster_70"
                     /product="hypothetical protein"
                     /protein_id="ncbi_KYF_009539-T1"
                     /transl_table=1
                     /translation="MGYIARTDDLPDIARKGGLVDPRAEDQPLFFERMSCRDVNEFVSN
                     PANVSPLSSGNPSAATKPTSLGMRLRQPAIQSQARIDEFRARSEEIKQRMPIRNVKQPI
                     SDLVPDLVVTGGLSRSPAFDCLPVFSHWADRTGELSATDLAATVRLTSTWGTAHVAAEG
                     VNMDAPRGAHAWSLKSHGIGPAEPGASKFSQQYDAETDTLTTTVNVARRLDTPRTDGVL
                     GAVSSVSWMRNARVADAVDCAAGLLSDASTLLEARDRMIATGAPEHVGFAEVRPVDMPS
                     WCSARKPLAPKLSGVAVASDPTAVNLFAGEDCQGPMLNTSVFAMTSGYNRGVYGGSISG
                     LWSTMDASFVMDYSIGVHSAAMADKLSIAFADAAAAAEKSAYAGAHITDISLVKGCNYS
                     CLRQKTVIEDSHPIPSRSTIVVWNDLARLARYKLADAVFCHVYYDGGGSEHMAAIAGLG
                     CVAHDWIDLGADVACGEVSNIIPSLTRGSLEEAPLAEVYARIIGAMIWYRDNDPYNPAA
                     NCLLFTHWWQLSNCRHRPVTLLGRTDLPVDAGIVPIVPDERPPLEHFRANGTKVERGAR
                     ALANAEARLEALIASDPLPETRAVIDLLVKPVLAYVKGGDTLPSENEYVGATLAAQVAY
                     PQDQKILEMWDLAIVMWECGALWASGVAGLCYTHAGLSNCDRARKDLSDTTWS"
     mRNA            16161..17234
                     /locus_tag="KYF_009540"
                     /product="hypothetical protein"
     gene            16161..17234
                     /locus_tag="KYF_009540"
     CDS             16161..17234
                     /NRPS_PKS="Domain: PKS_ER (24-219). E-value: 1e-22. Score:
                     72.3. Matches aSDomain: nrpspksdomains_KYF_009540_PKS_ER.1"
                     /NRPS_PKS="type: other"
                     /codon_start=1
                     /db_xref="InterPro:IPR011032"
                     /db_xref="InterPro:IPR013154"
                     /db_xref="InterPro:IPR020843"
                     /db_xref="InterPro:IPR036291"
                     /db_xref="PFAM:PF08240"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028:crotonyl-CoA reductase / alcohol dehydrogenase
                     (Score: 145.1; E-value: 4.7e-44)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="KYF_009540"
                     /note="EggNog:ENOG41; antiSMASH:Cluster_70; GO_function:
                     GO:0016491 - oxidoreductase activity [Evidence IEA];
                     GO_process: GO:0055114 - oxidation-reduction process
                     [Evidence IEA]"
                     /product="hypothetical protein"
                     /protein_id="ncbi_KYF_009540-T1"
                     /transl_table=1
                     /translation="MSLPDTYLAATVPTPQSPHTLTTHPVPTPNANEVLIKITATAVNP
                     VDWKMRDYNFFLTEYPAVLGSDASGTIAAVGPNVTTFTPGDRVFFQGIIGNYAASTFQQ
                     YCVMPAELVSRTPSNISDEQAAGISLASVAVVTGMYDSTGHGIAPAPWAEGGDAAGKGK
                     AIAILGGASSVGQYAIQFARLSGFTKIITNASVVHREYLQGLGAHVVLDRKIAKAEDFV
                     AAAGEVPIRYVYDAISMKETQVLGVEIAKASKGAAKAVVTVLGAEKEAAELGKEGEHQV
                     EVRQILGIGASPKLRHVSEPMVKVLGGEDGWIAKGLFVPNRVRVVPGGLGAVEEALKTN
                     KEGVSGEKVVFRPNEGA"
     aSDomain        16233..16817
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_KYF_009540_PKS_ER.1"
                     /evalue="1.00E-22"
                     /label="KYF_009540_PKS_ER.1"
                     /locus_tag="KYF_009540"
                     /score="72.3"
                     /tool="antismash"
                     /translation="PVPTPNANEVLIKITATAVNPVDWKMRDYNFFLTEYPAVLGSDAS
                     GTIAAVGPNVTTFTPGDRVFFQGIIGNYAASTFQQYCVMPAELVSRTPSNISDEQAAGI
                     SLASVAVVTGMYDSTGHGIAPAPWAEGGDAAGKGKAIAILGGASSVGQYAIQFARLSGF
                     TKIITNASVVHREYLQGLGAHVVLDRKIAKAED"
     CDS_motif       16659..16706
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_KYF_009540_0001"
                     /evalue="1.60E-02"
                     /label="PKSI-ER_m5"
                     /locus_tag="KYF_009540"
                     /score="8.1"
                     /tool="antismash"
                     /translation="ILGGASSVGQYAIQFAR"
ORIGIN
        1 atgacttgtg cctaactgat agtgatgctc gccagtgatc gatgtaggag tacgctgaga
       61 atttccactc cctttctgcc accggaaggg ttggtccgtc cttgctgaca tggtcgattc
      121 actatagctc taggtcgtcc ctgtcaatac aaacgcaagt tcaagaaacg aggccgcaaa
      181 gcggccgtca accacaagag tccgctaccg gccgaagccc attgcgatct agatgtaccg
      241 agtactccat cttccggagg gattcatcca acctcctttg gaccagcccg cgacgaggcc
      301 tcgatagatg gcgtaccagc ggtttcgggc tttcttgcga tgggccgcga gctaccagag
      361 tcacacgagc cagtgaacat gaataatgtc gaggccactt tcggaacata tcaggccaat
      421 attccccggt catttgactt atcgcagcct gagtcggggg cgactgcgct gtccccaatc
      481 cctcgatttc ccacgctggc gctaactccc cgggatgcta gcgcaacgtc ggcgtcaagc
      541 acgtcgttgc ccgcgggctg ccgctttcca tgtctcgagc ccctccttcc tcatctgaag
      601 agtgtcttga gcccagaaga cgcttgcagt ctgctcgaaa tcttctttac cgaacccggt
      661 gagtccgccg gatcctccca tagcccctac gttctctctc ccgtgcttcg aagatccgcg
      721 gtcttggatc cgatcaagcc gcggccgacc tctccagcgc ttctggcaac aatgctttgg
      781 tgtgcagcgc acacggcaaa tgggagactg tactatatcc caggatcgcg ggcacgaatc
      841 gttgatcacc tttactgcct ggtgatgtcc ttactgcagc gcctagaccc ggataattgg
      901 cgtcgcgtaa acggtaagtg tatatctgca ccctcccatc aaccccgggt gatgaaagta
      961 tccagtaggc aagcggccaa taattggagt tagggggctg gcagttggaa aacgactgtg
     1021 tctccgccct tgatgctgga gacccagacc gcgctcgcag gactttcggg actggcccta
     1081 cccctacggt agacgatgtc ctcacgttcg tcatcctgac tatcgttatt tccggtggcg
     1141 aatacaagtc agactgcttg aagtggtgga acaaagcact tcgcttgatc aagcatcttg
     1201 ggtttcacca ggaccccttg cggactggcc agccggaacg gggatcactt cagatcatcg
     1261 aagaacaaga agaaaaacgg cgggctttct ggttggtcta tgccttggat cggcacttgg
     1321 ccgtatctca caatcgtgcc gtttatctca tcgacgccga atgtgaagtg cttacgcccc
     1381 taccagaatc ttgctggcag aggctgcatg cctttacagc tgacaccctg ccctcgagga
     1441 cctacggccc gccaactgtc atttcgggaa ctgggctctt tgagtacttc ctccccttga
     1501 tgtctatttt gggggatatt atcgagcttc gtctgtggcg ccaccatccg cgactgaaat
     1561 tcgacgagca tgccgtggta agcgccatcg atatcgcact taccaattgc catcagagtg
     1621 tttcagaatg gcttcgcgag gtaggtcaga ctgcaaacgc ctcgcgacct ttctcgacga
     1681 ctccacgtgc cgaggtgaca atggcatacg cctcatatat tatcaaggtt ctctttgtaa
     1741 tgctgtatgg ggaatgggat gccaccagta tgctggaaaa ccatggggac tggatcacct
     1801 ccgcacaatt ctctgagtgc gcctctcatt caatcgctgc agcccagcaa atctcctatg
     1861 tcctctcgat cgatcccgaa ctgtcgttca tgccctacct ggtggggatt tatcttttcc
     1921 acggcagtct cgtgcttctt ttgtttgctg agcgaatgcc tctcgttggg ccgaacccgt
     1981 cggtggagga agcctgtgaa gtaatcatcc gcgcgcatga agcttccatc gtgaccttga
     2041 gcacggactt tcaggttcgc atactccggt ttccacttta cctcccctta ccttcctagg
     2101 caacgtgtgc cttgaaaccc atgtctgaaa ctaacccatg ttaaagaaag ctttccgaaa
     2161 ggctttccga tcggtgctgt tgcactctcg tgcccaaggg gaggtgaata ccgagcttag
     2221 agccttgcgg caggatatat tgtctatgta ccgctggaca ttaggggacc cggggctgtg
     2281 tctgtagata aacgcatggt acaggatact gtgtcactaa taaaaccagg gtttgttata
     2341 tggcgagaac cgtctagggc gatatctccc gtgttgcggg atggttgaaa cgtgctcgag
     2401 cacgccaggt caagctgtat ttctaggcat gcacaagcgc ctgctcactt cgcctactga
     2461 cctcggatgt ggattgttag catattatcc ggccaggagg ggatttcctc gtctggtcta
     2521 gcgtttctac attggtatgt tccttgttga ggcgcgttag ggtgttttag gcgttcaccg
     2581 ggatttcact tcagccttgc aaatcgcttt cattacgtta cacgaactgg attatgtact
     2641 actatggata cattccgggt acatgttcat attgatttgt atggtcccgt gcaagctgtt
     2701 gtcggaaggg cgtctgccac cagtgcctcg agccagcggt ggagggacta ccactagcat
     2761 cacggagcta gcttgtaaga tcgagatatt ggataaaggg taaaataagt gctttcggtc
     2821 cttcggtagc ggtgtgggtg atgccgagga ttttacatac caccgagggc accactactc
     2881 tcacccgtac aggcccgtag agtagggagc taaaaggagg cgaaatgttg agcaactgaa
     2941 gttactatag tcccttcttc ttcttcttct tcctcctctt cttcttcttc ttcctcctct
     3001 tcttcctctc taagtcttaa actgttattc ttatcgctat tataattatt ttgcccgtcc
     3061 gaaagattcc cctgatcaag cacacctagg gcaaccagtt caccgtgaca gaacgctccc
     3121 gaacgctaca gcgtttaatg ccaggcgatc catatctgac ttttgccatt accatgagaa
     3181 gatagtcatc tcggactctt gatggaatta ttagatggtt tattgttctg tgcttgggtg
     3241 ggtcaaccgg gtctttgctg gcagtccttc tgtcaagtat taaggcggaa atcggctaaa
     3301 tcgggtatta agtctgattg atcggcaaat tgccctgatg ctaataagat tgcaataaca
     3361 acatctaaat catagaaaac attcctcata gatcaaagga gcgcacatac attactatac
     3421 ctctttttcg ttctcctgtt cctttccttc tgctgccata gactattgtt gtgacctccc
     3481 tccacttccc aacgatgttc gagtcaaatc ctctccatcc aaccctaacc ctccctccaa
     3541 taatccttgg cggctcaggc ttcagcgaac aatcccaccc caatccacaa actctccccg
     3601 ttgcaacaat catccgtcgc gcctttgacg aaggcatcct tgctatcgac acctccccct
     3661 actaccaccc ctccgagcac ctcctcggca ccgctctctc cgacccccag ataacaaccc
     3721 gctacacacg cagcgactac attctcatga ccaaagtcgg gcgcctctcg accagcgtct
     3781 tcgactattc ccccacctgg gtccgccaat cagtccacaa ctccctcgag cgcctacgca
     3841 ccacctacct agacgtagtc ttctgccacg acgtggaatt cgtctcggag catgaagccg
     3901 tccaagccgt cggtgtgctc ttcgacctcc gccaacaggg ttatatcaag tacgtgggca
     3961 tctccggcta tccgctcgag acgctagtct ctgtcgcgca tgcagtgcga cacgtatatg
     4021 gccagccatt ggacgtcgtg cagacctggg ctcagttgac agtgcagaac actaagctgg
     4081 agcggtatgg cattccggct cttcgtgagg ctggggtgtc ggtggtttgt aattcgagtc
     4141 cgcttgcctc cgggttgttg cgtgcgggaa aggtgccttg tgggagactg ggggattggc
     4201 atcctgcgcc tgaggggctg aggagcgctg tgagtatcgc ttcgggttgg ttggagtgtc
     4261 aggggttcgg gttggcgggg ttggcgttgc ggttttcgtt ggcgaaagct gtgcgggctg
     4321 ccgatagata cgccgtctct gtctctactg tcctgggggt atcgtccttg aaggatgtgg
     4381 aagaggatgt ggaggttgcc cgggacattt tacgtgatct ggatgctggg cttgtgtata
     4441 aaaggatgga agtgatgggc ggcctgtcgc gtcttcgatg ggtgaatgaa gaggttgaat
     4501 gtcgggattt acggctgtgt tatggcgtgc ggaacatctt gggggaatgg gctgagtatg
     4561 acttgcagaa ataagacatt gctgtataag taggaccttg atatagaata tatagacaga
     4621 tatatttgac ctgttctatc ttgtcagcat cattcagtac cgtgtagatt acatcagatt
     4681 cgtggaagac aaagacgaac tgcaacacta cgtgcatgcc ttgaataagt acaacactgc
     4741 agtagcaata gggctgaacc catgttcatg ggacttgaat aactaccttc ccagaataat
     4801 gaaaattttg tggatagtta tatatctgcc tggtctgatt gaagagaaag taacagtcaa
     4861 ttactaacta catagaatac ctcttgaata atcctagcat cttccgtaac tacttctata
     4921 attctattac tatatctgaa atagggaaga tttaatctca agctaggaaa gctaaaccta
     4981 gatgatataa tcttctatct agactaacta cctagtagta gagtggctaa cgaccaaggc
     5041 aggtcggatt aaggaaagga ctcatatctt ctatcagatc aacaagcagg gtaaaatact
     5101 tcttaaggtc aattcaaaac ttggaaataa tcgcttctag tgatggttta gacttaagtg
     5161 cgcacactcc caactgcgcg taatcatgca ctttctggtc ctcgtaggtt tcactgatgt
     5221 tggatgctta attcatctcg agcaggtagc ttacttcaga tcttagtaac cactgggacc
     5281 aatatgcata gtcattttta ctgccaacca gaaataacgt gatatgctcg ctagagtacg
     5341 tattcctcat catgcacagt tttgaggaca ccagtcagaa gaaacctcgc tttccagcca
     5401 gattcgcccg attaatcttc aaagcagcaa gcacatgcgc atcatgcaca tatgatatgc
     5461 catgcagaac cttacccgtc cagatcctgt ccggcttctg gcccatcgtc catgtctcta
     5521 acaagaattg ctttccccta gcaatggcca ggtctgcttt gctgtaatca ctaacaatgt
     5581 cagcgtgcga cgctagctgt gcaagcgcaa tgatcgcgta tgctgtctcc tcagcgccgt
     5641 gcatgttgcc ccaggagcca tcatcattct gtccacgaag gacacggtcc actacctctc
     5701 gcagacatgt cgatatatgc ttttcaacga tatcttctgc tagacctgga atgcatccct
     5761 ggtcccagag gactctgacc gggacgagtg attgagcaat gtgcatgata ccgtaatatt
     5821 cggataagtt ctaaagtaca gcggttagtg ctgtggtaga cagatgtgga gctcatttca
     5881 gcgcaggtac ccagtgatcg tggagggtct tctctttgct ccattttgtg cacatgaact
     5941 tggcaaaatt ctctatctgt ggggtgaagg cactgggatc ggacgaggaa aggaggcagc
     6001 ttagtacgtt tccgttgacg cttacgcttg tcacccgttg gggcattcgg tcatcgaaag
     6061 tctcgaagcc atcatcgcac tcaaacttcc taattagatt tgcacggcta actgcatagc
     6121 cattgttatt gagaaccatc aacgcccgtg ctgtatcgtc cgcgtcgggg aagaaggtat
     6181 gggctggagg attactatct atccactgcg gcagaaattt ggcctgaatt atacttacta
     6241 gcaccggtca cgccattaga aatagaccta tgaatcaatt cgaccagctc acccacgttc
     6301 tgtgctccca agttttcgac cgtgaagccg ctgtccagca gggttgacaa aacctatagg
     6361 atgaagtgtt agcggtaacc ctagtagccc ttcctcgcat ccttgaatgc aacttaccca
     6421 gcagggctca aacacctcca aaggatatac acccccggcc ccgccacttc ccttcccttg
     6481 gccgtgcgac acaatatgac gaagatatgc ctcgcactta tcgctccagt taggagagaa
     6541 tattaggtac gccgccgcag aggctggaga agccgttata cccgaagaag taacgagaca
     6601 ttccagcttg tcccactcaa gctggctcgc gaacccttcc agcgaaaaca gagggatact
     6661 gcaggggccc tgatatagcc agctaaggtc aacgctagtt gctgcggtaa acttgctcaa
     6721 caagtcgtcc tttgcaggaa actgaaagtc tacaccctct tcacgcagaa gatggagtag
     6781 gaccggaaca atcagttcaa ccgtgagatg aataccatca tctggttgcc acttttgcag
     6841 cttagcatct agaaacgact tggcactaaa gagtcgaaac aagatatcgt cgggtagggg
     6901 ttctcggtga tgggatgaag aacgccggac atgtctacac agggcgagaa gggcagccaa
     6961 cgaatggata acacagtctt ggatccagat attttccgga tacccgctgt gctgcctggc
     7021 gacgctttcg agggcatccc aaccaccatc attcgtttgt tcgcgcagga ggtactcgaa
     7081 gctgcttgga aagagccatt cgtatccttg atctgttctt ttctcgacca tggccagcca
     7141 tgcagtgtca tagatcgatg gagccataga ggaaaatcca tattgtgact ttgactcaga
     7201 ggcgaccttt gcgatgaggt ctttggcaca ttggactagt atagaggaac tcatacttga
     7261 cttcagaaga ttgtggggta agctatcggt aggcagtaga aacctgagag agcagagata
     7321 agagagaaaa cgaaatgata gaaacaaact ttcacggaat gttaatttct tgaactagta
     7381 tgctttatgt gagatctaga gccttgcgcc catatatctt tcttttacag cagtcacgat
     7441 cgaagtagtc ccgaccgctc tggtgtggtc tgcaaggtat gaggggctca cagtcgcaca
     7501 actccagttc aactgcggtg cttctaaatg atgaaaaccc taagccacta ggattgtttt
     7561 aacagtggtc tgcctggtga ccgcattgac tggacaccgg gctcaccgaa acaaggggta
     7621 gatgcatcta cgccgtgtaa ccgcaccgag gcacgtgtga agaaatcaag ccatcacgtc
     7681 tgatttgagt ttgttaaata tgtacttcag aaagcaggtc taaagcatat gtctcagcca
     7741 catcagctgg attagtacaa ctagcgtatt aagtgcattt gaaagcacga tatggttttg
     7801 actgatgtac taggaattct atatagccgt ggcttttgca gtacctaggt ggctgtgctg
     7861 gcccttgata cctataaata cataagacta gtgatactgc ataatagtcg tgattataga
     7921 tactacagtt atattgaatg acgttcatcg aagccaagtc gaacataata agcaatccgc
     7981 catggagcaa cgtcaagaac tgtgtgactc actcaaagga cagtatgctg ttctacctaa
     8041 tctctactcc ttgttcccag actggtcacc agaattgcat ccagaatata caagggcccg
     8101 agatgaatct acaaacccgt ggatcaaacg gtgcgtcgac tttgatagat tcctagcaat
     8161 acacttctcg gtcttactgt cagacagctt tgccaagaac ccactagttt gtcggaagct
     8221 tcaggaagcg gatttcacga cattcgccgc agttatgtgc gcaaaatcat cctttgaaca
     8281 actctgtacg gtggcaaagt ggtttacctg ggtaaatgtg tgaaccaaga ccttctgacc
     8341 gtttactgat aacagtacga gtacttcata tgggatgatc gtatggattc cccatctact
     8401 acatactagc gttatactga gctgaaacac ccctcaagta ttcgactgcg gctcccttag
     8461 ccacgattca aaaactatca agaggtacaa gcatactagt atcgaatatt tcaagcatgt
     8521 cctttgccat gaagcagcgt atccagattt atctgaattc tccgaggaac tccaaaacgc
     8581 gctacgctgc tgggacgaga tagcagaaca tgtgcgtcag gtgtgctcaa aaagaatgtc
     8641 ttacgtccca atggtttgct ttcttccaat actgacggtc tgaatttagt gacgcgcaag
     8701 gttctgttag cggcgatgat agattatctg tcgagtgttg atggggtgga ttcgatctac
     8761 tcagagggtg aaattccctc agtacagcag tactggcgcc gacgagaccg cacagctggc
     8821 gtccatccag ttatcgcaac tattccgtat gtcttctcaa acattttgtc gagctgtggc
     8881 tgacattttt acagctttat ctatgacttt gatatctcag cgcgggatat ggatgatacg
     8941 catatgaaat tactccggag acatacatcg taccttgtcc acatgtaagt ccgctctgat
     9001 gtcggatcca ggactttaac tgagttgtca cagacagaat gacatgtttt cgctgagaaa
     9061 ggaggtggta aataggtgcc tgtcaaggtg ttggaatgtt gcacatagct aacatttgtg
     9121 taacagagag ttggacaagt cgagaacctt gttccaatca ttatgctgaa cgagaatctg
     9181 agagccagcc aggcaatgaa agttgccttc atgttcgctc aagaatcagc aaggggcttc
     9241 gatgaagtgg ttgatgatat gcggcagact gccaagggaa gacgccgcgc tgtcgcagac
     9301 attttcatca aaggctgcag aaacatcgtc atggggctca cccattggag gtaaattcac
     9361 aatagactta ttgataagcc ctgcgcttta ctgatgttgt tttctagcta caccggagag
     9421 cgttatttcc gagctggtga ggcggatgaa aaccacacca tatatttcga actgtaggct
     9481 gggtgttcct tttctatatg ccatttgcga tcttattcca ctcgttcaga gtagttgcag
     9541 cgtcttcctt tggtgtttca cggacgaaag tcaggcgtca ggctcttagg gatgatctcg
     9601 catcatcacc tcagcgacta cccttacatt cttagacagc aatctacaca aagtttatgt
     9661 gcagtaagaa gacattattt tgagtttcac cgaagcatcc gaaacgtcaa tcattgcttc
     9721 agttcatctc ttcaagatct tattccacac cgactgattg gatcacaaca agaattccac
     9781 gcacaccccc catctttcaa aaagcaaggg atgataacct ccgcggaagt gggggatttg
     9841 tggcgcaggc tgatcaacaa cctgaaaaat ggcagatgtg gaataatatg catatgttat
     9901 gcagtaccgt cactcatcgt atatcaatca tgcatgcaca gacaacaaat aagaaatttc
     9961 gaccgcagaa caattccgtt atcccggcaa aatctttggt tgcatgaagg gacacatgaa
    10021 caaaatcttg atttgacagc aaactacaag ggatgacatt atcacgagta tggtttctga
    10081 attgatttta gtgcttagct ttcctgccag tggatagtct aagctgacag acgcagtatg
    10141 tggtgtaggc ttactggtca gatgtaacat cccttgccag ctgagtttcc tggaacttag
    10201 tcacgtcgtg ggctgaggct gcccaccgga gtgttttatt acatgggtgg atgcttgaat
    10261 taaatgtgtg gtacattact gatcgttcta tacattcagg tgattagaat gttctagaag
    10321 tatgttctgg tacagttgac atacgtcaag gggagtgtac attctggaaa tatttataac
    10381 caacaggtaa gaacgcagag catatcatag ggagtaaagt acaaaaacat agaatccttc
    10441 aatcatgact cataaatctt cgtggttccc gaggacagct cctggagttc ggatgaaaga
    10501 ccagcgaacg agattgtaga cttgtgtgga tagtgggtaa tccctgtatc ttcctccttc
    10561 attgtgcgaa gagattctag ggctggaaat gtcatctaag catgctagac gaaatggcga
    10621 agtgtccggt acagcttaca gcgtggggta catttgtgga acccttaagt ggccaactaa
    10681 tccctcataa gctccatata ctatgggtag catttccgtg tcgaatacgt cgcctcccca
    10741 ttatcgcatc acggggtata ttttcgacct tgtctgttct gagaatgaag cgaaagagaa
    10801 gtgacatcaa gatgatgatc aaaagaccgg ttaagcaaag gaccggtgtg ggcgccagaa
    10861 agcagaacgc tgaggagcat acgtatgctg aaaacatgag tgtagatagg atgaataatt
    10921 cgtaagacca agagtgtggg ctaggctggt ttgtatcttg cccgagaaca aagaccggtc
    10981 aggttaaagt ctgcggttag agcggttatg gagctcgtcg acttggtcac ataaggagtc
    11041 aacgattata tttggtggcg gtttcagatc agctgaggtt tgagggcaat tatatctctc
    11101 aacactttga aagagtgggg gcgtaggcgc atatggcttg atcatcgcaa gttccgcggt
    11161 atattaactt tagcgaacta gtatattgtg caatggtcag gcaaggtggc aaatgtctgc
    11221 ttatggagag cgtatgagtg gatgaagatc tacttcccct gtagaccgtg atagggatcc
    11281 aggtgaacgt tcatataagt ccggggagcg ggtggaaggg ttgagaaatc cgatatgtca
    11341 aagagatgca aggcatgcac gccctaacat ctagtcgcat atcagctggt ggtctttctt
    11401 ggcttcagcc ttaagcgggg tgaccgagaa actggtggca tatcatttga gataggaaac
    11461 aagctcatac ggtgttgatc agaggtttcg ttctcagtta cgtccgaatc tgctgcatgg
    11521 aagaaggcac attcaagaga aaatacattg catatactgc agacttttgc gagtaggata
    11581 atgcgaccat catcttgaag cgccaaggga agcaaagggg gctgtgccaa gtggccaaag
    11641 ccaatgcgtg tgtgcatcgg tacggaatcg acagtggaac gattcgatag gttagggagc
    11701 caaatcgaaa cgatcgggta ccatgatgac gagtagtaca cgggactatg ctcttcattt
    11761 ccgattggtc ccgatcatcc gcggattagg gagagattgg ctgagctgaa tctgcgctga
    11821 cagcggggaa taagatcatg acagtctgca ggacaggggt aatgaaggtg gagttgtgct
    11881 gtcgttccaa gtggcagagc actacgctta gtacgtttta atctggcggg gagaaaatgc
    11941 cagcgcataa tgagtggagt tagcggttcg gctctttggt ggtggaagaa cgcttcgacg
    12001 ggaaacacca ctcatggaga agggttacat gtctgtttct cctgtttatt gaattagaga
    12061 catattttca ttttgagtca tatcttattt cccttttctg gggggggggt cttttgttct
    12121 ttacattttc tggtgtcaat tgagaatgct gtataagggg ataatcttgg tcagcaattc
    12181 aactttatca ggtattaaaa ttcagtgagg ctgtcgtatc tccccccgcc ctcccccagg
    12241 aggaagagcc cgcggaatct gccaaaataa ttgagtttgg gcttatgtct gacacgcttc
    12301 actcgggcaa tggaggctgg ctgagcgggc ctgcagccaa gtggttcctg aatcatggct
    12361 cgcaggctgg cctgtgtctc tggcctgagt tgggctgaac ggaggaacgg ctgtggcccg
    12421 tgttaatcta ccctctctcg atctatataa aaaggtccaa caatgagcgt ggtcatggac
    12481 agaaatcaac tcaggcagct cagagataac tggcttcaag aaaagtccta gtctcgagag
    12541 tacctggaga cgtgaatcca agagtcttcc tttccctttt gttatctctc ttcgctctat
    12601 aagagcaact taattcccat caactatctc ccttaagcta ttctttttcc cgagagacca
    12661 catcgttcct caaacatctt ttcaagatgg gctacattgc gcgaacagat gatctccccg
    12721 acatcgctcg taaaggaggt ctcgtcgacc cccgggctga ggatcagcct ctcttcttcg
    12781 aacgcatgtc ctgtcgggac gtgaatgagt tcgtttccaa tccggccaat gtatctccat
    12841 tgagctcagg aaacccaagc gctgctacta agcccactag tttgggcatg cggttgcgcc
    12901 agccagctat ccagagccag gccagaatcg acgaattccg cgcacgctcc gaggagatca
    12961 aacagcgtat gcccatcaga aacgtcaaac agcccatatc tgacctggta ccggatttgg
    13021 tggtcaccgg tggtctcagt cgctcgcccg ctttcgattg tctgcctgtc ttctcccatt
    13081 gggctgaccg cacaggcgag ctctccgcta ccgacctggc tgctaccgtc cggcttacct
    13141 ccacctgggg cacggcccat gttgcggcag agggagtcaa catggacgcc cctcggggag
    13201 ctcacgcctg gtcactcaaa tctcacggca taggccctgc cgaacccgga gcaagcaagt
    13261 tctctcagca atacgacgcc gaaactgaca ccctcaccac aactgttaac gtggcgcgcc
    13321 gtcttgatac tcctcgaacg gatggtgttt tgggtgccgt ctccagtgtc tcatggatgc
    13381 gcaatgcacg tgttgcggac gccgtcgatt gcgccgccgg cttgctctca gacgcctcga
    13441 ctcttttgga ggcccgcgac agaatgatcg cgaccggcgc ccctgagcac gtcggatttg
    13501 ccgaggtgcg ccccgtcgac atgcccagct ggtgctctgc ccgcaagcct ctcgcaccca
    13561 aactgagtgg cgtggccgtc gcatctgatc caactgcagt caacctgttc gccggggagg
    13621 actgccaggg ccccatgctc aacaccagtg tgtttgccat gacaagtggt tacaaccgtg
    13681 gtgtctacgg tggttcaatc tctggcttgt ggtcgaccat ggacgcatct ttcgtcatgg
    13741 attactccat cggtgttcac agcgctgcca tggcagacaa actctccatt gcttttgccg
    13801 atgcggccgc tgctgcggaa aagtccgctt atgccggcgc gcacattacc gacatcagcc
    13861 ttgtcaaagg ctgcaattat tcctgcttgc gccagaagac cgtcattgag gattcccacc
    13921 cgatcccttc tcgttctacc atcgttgtat ggaacgatct ggcccgcctt gcccggtaca
    13981 agttggccga tgcggtgttc tgtcacgtct actacgatgg aggtggtagc gagcacatgg
    14041 ctgccatcgc cggtctgggc tgcgtcgcgc acgactggat tgaccttgga gccgacgtag
    14101 cgtgcggtga agtcagtaac atcatccctt cattgacacg aggttccttg gaggaagccc
    14161 cactggccga ggtttacgcc cgcataatag gtgctatgat ctggtaccgc gacaacgatc
    14221 cctacaaccc agcagccaat tgcctcctct tcacccactg gtggcagctc tccaactgtc
    14281 gtcaccgccc cgtcactctc ctcggccgga ctgatctccc tgtcgacgcg ggcatcgtcc
    14341 ccatcgtccc cgacgagaga cctcctctgg aacacttccg ggcaaacggc accaaggtcg
    14401 agcgcggtgc gcgtgcgctt gccaacgctg aagcacgtct tgaggctctc attgcctcgg
    14461 atcccttgcc ggagacccgt gctgtcattg acctccttgt caagcctgtt ctcgcttacg
    14521 tcaagggcgg tgatacccta ccctcggaga atgaatatgt cggagctacc ctcgctgccc
    14581 aggtggctta tcctcaggat cagaaaatcc ttgagatgtg ggatctggct attgtcatgt
    14641 gggagtgtgg tgcgctgtgg gcgtccggag tggctggact ctgctatact catgctgggt
    14701 tgtccaactg tgaccgggct cgtaaggact tgtcggacac tacttggagt taaaccttgt
    14761 gccaaagtac aatgcaagtc aacaggatga gctagctttc agacagcatg aaagacagtc
    14821 tttgtggcgt ctcatagaaa gaattgcttg cgcttacata gcgtttactc tattctaggc
    14881 taggttagat tgatattcag gttaagaata ggaagctttt ttttttttca tttctctatg
    14941 aatcatcaaa attatgcgag ctaagttcga cgaagataca acagccagcc tcaggcatac
    15001 ctagggcctg tgttccggaa cgggttaggc ggtaagtcta tgacatgccg tactgtaatt
    15061 ttcctcgaat attattaccg gataagcttc catgtcaagc cacacttacc aaaacaggaa
    15121 tcgagcggga aagcttgtca aggaccaagt ctatgacctc cctccatatc ccatattatc
    15181 attactaccc attatcaatc caattgctta tattgacctc tattctactc tattcattaa
    15241 tacaatttag tagacttaag ctacagactg tttctgcaat agtcctcagc tagtgtcagt
    15301 agacgtagtg cgatgcggat agaactggtg aagtatatat tccttgctag cagtcagggc
    15361 taccctgaac tggacacctc tgaccactct ttcaggcaga tagtagctgg catctccatt
    15421 tcggtcaatc aatcctatgg tcagaggaaa tgctatgcct gcgaggatca tgatgttatg
    15481 ctactattgc attgaccatg ttgggctgca tggcttatat gcgaagatta acaaaagagg
    15541 aaagacgcta tctgactgca gatgcttgcc gcagatccgg acgcaagtta agaccaaggc
    15601 accagtttca ctcaccactt aaaagagata catgcatgat ggaaagtact ggaagtactt
    15661 ggacagttac tgctaactgg attatactat gttacgcatt ggccattcat ttgaagactg
    15721 gttactcttt tggctcaacc gttttcgata ggcaattaat gtcagtgact tctacaactt
    15781 ctacatgaca gacacatgtg tttttacagc gtgcagccat gttcatacct tcaaaatagg
    15841 cctctcccag cttctctaat ccagatacac catcgcccta tccataacat gcaccgcata
    15901 accaagcaca ccccagatta atgccccagt ggagtcgatg actaatgtcc atgacctcat
    15961 tacaaatcag ccactggatc cctatataac ctcatcatcc aaactaaagt accacccctc
    16021 atgagctata atctgatcct catatcaaca acgcccgtca gcaccttatt ttcctttcca
    16081 ccaaccacac tcttccacct caatccaaca acaataccac caacaccacc acaaccacaa
    16141 ccacaaccac aaccaccata atgtccctcc ccgacaccta cctcgcggcc accgtgccca
    16201 ccccccaatc accccacacc ctaaccaccc accccgtgcc cacccccaac gccaacgaag
    16261 tcctcataaa aatcaccgcc acggccgtca accccgtcga ctggaaaatg cgcgactaca
    16321 actttttcct gaccgaatac ccggccgtcc tcggctccga cgcctccggc accatcgccg
    16381 ccgtgggccc caacgtcacc accttcaccc cgggcgaccg ggtcttcttc caaggcataa
    16441 tcggcaacta tgctgcctcg accttccagc aatactgcgt gatgccggca gagctcgtct
    16501 cgcgaacccc ctccaacatc tccgacgagc aagccgcggg gatcagtcta gcgagcgtgg
    16561 ccgtcgtgac gggaatgtat gatagcacgg ggcacgggat cgcaccggct ccctgggccg
    16621 agggcggtga tgcggcaggc aagggcaagg cgattgctat tttgggcgga gcgtcgagtg
    16681 tgggacagta tgcgattcag tttgcaaggt tgagcgggtt cacgaagatt attacgaatg
    16741 cgagcgtcgt gcatagggag tatttgcagg ggctgggagc gcatgtggtg ctggatcgga
    16801 agattgccaa ggcggaggac tttgttgctg cggctgggga ggtgccgatt cgttatgtgt
    16861 atgatgccat ttcgatgaag gagacgcagg tgctcggggt ggagattgca aaggcgagta
    16921 agggggctgc gaaggcggtg gtgacggtgt tgggtgcgga gaaggaggcg gcggagttgg
    16981 ggaaggaggg cgaacatcag gtggaggtta ggcagatttt gggtattggg gcttctccca
    17041 agttgcggca tgttagtgag cccatggtga aggtgcttgg aggtgaggat ggatggattg
    17101 cgaagggact gtttgtgccg aatcgcgtgc gcgtggtccc tggtggattg ggggctgttg
    17161 aggaggcgtt gaagacaaat aaggaggggg tctccgggga gaaggtggtc ttccgtccca
    17221 atgagggtgc gtag
//
