LOCUS       OGUI01000002.1         15734 bp    DNA     linear   PLN 19-AUG-2019
DEFINITION  Aspergillus niger.
ACCESSION   OGUI01000002
VERSION     OGUI01000002.1
KEYWORDS    .
SOURCE      Aspergillus niger
  ORGANISM  Aspergillus niger
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Eurotiomycetes; Eurotiomycetidae; Eurotiales; Aspergillaceae;
            Aspergillus.
COMMENT     'Annotated using funannotate v1.6.0-df4262f'.
            ##antiSMASH-Data-START##
            Version      :: 5.0.0
            Run date     :: 2020-11-02 07:37:12
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 150543
            Orig. end    :: 166277
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15734
                     /aStool="rule-based-clusters"
                     /contig_edge="False"
                     /core_location="join{[160735:161406](-),
                     [159229:160675](-), [159089:159180](-)}"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(join(8547..8637,8687..10132,10193..10863))
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     cand_cluster    1..15734
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..15734
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="1"
                     /rules="(Terpene_synth or Terpene_synth_C or phytoene_synt
                     or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps
                     or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /tool="antismash"
     mRNA            complement(join(1..295,397..773))
                     /locus_tag="ATCC64974_7830"
                     /product="hypothetical protein"
     gene            complement(1..773)
                     /locus_tag="ATCC64974_7830"
     CDS             complement(join(1..295,397..773))
                     /codon_start=1
                     /db_xref="InterPro:IPR007128"
                     /db_xref="PFAM:PF03980"
                     /locus_tag="ATCC64974_7830"
                     /note="GO_component: GO:0000818 - nuclear MIS12/MIND
                     complex [Evidence IEA]"
                     /product="hypothetical protein"
                     /protein_id="ncbi_ATCC64974_7830-T1"
                     /transl_table=1
                     /translation="MSTEPNPSAQRPGASPSPPPPAPVPLTPGPRASKLQEIFDKALAR
                     TLRANSYANFSGCFPTPAKHVPASLESVWRQLNAKLEESAKAEFEDILAERDAVRQLNE
                     LDRLVGEAKVRKDRGVGGDSVAPHTLSPEELYKAHLLPHLMETQADLDAKINSVQNQNA
                     ELAEKVQAQRSEIESLLSGLEAVVADLEGAAAATTQFTSEHQLRQEAAQMDGEVKARSE
                     I"
     mRNA            complement(join(1561..2481,2549..2572,2655..2879))
                     /gene="PHO85_1"
                     /locus_tag="ATCC64974_7840"
                     /product="negative regulator of the PHO system"
     gene            complement(1561..2879)
                     /gene="PHO85_1"
                     /locus_tag="ATCC64974_7840"
     CDS             complement(join(1561..2481,2549..2572,2655..2879))
                     /codon_start=1
                     /db_xref="InterPro:IPR000719"
                     /db_xref="InterPro:IPR008271"
                     /db_xref="InterPro:IPR011009"
                     /db_xref="InterPro:IPR017441"
                     /db_xref="PFAM:PF00069"
                     /db_xref="PFAM:PF07714"
                     /gene="PHO85_1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs)
                     SMCOG1030:serine/threonine protein kinase (Score: 171.7;
                     E-value: 3.5e-52)"
                     /gene_kind="regulatory"
                     /locus_tag="ATCC64974_7840"
                     /note="GO_function: GO:0004672 - protein kinase activity
                     [Evidence IEA]; GO_function: GO:0005524 - ATP binding
                     [Evidence IEA]; GO_process: GO:0006468 - protein
                     phosphorylation [Evidence IEA]"
                     /product="negative regulator of the PHO system"
                     /protein_id="ncbi_ATCC64974_7840-T1"
                     /sec_met_domain="Pkinase (E-value: 8.8e-77, bitscore:
                     252.5, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MDMDGRDRSKSRTLQPPTADYLDLISNLASPKTFLFHPPRSTSRS
                     HPTPAAQSTTVAPSTTMDKQQPSSFQQLEKLGEGTYATVFKGRNRQTGELVALKEIHLD
                     SEEGTPSTAIREISLMKELKHESIVSLYDVIHTENKLMLVFEYMDKDLKKYMDTRADRG
                     QLDQATIMSFMHQLLKGIAFCHENRVLHRDLKPQNLLINKKGQLKLGDFGLARAFGIPV
                     NTFSNEVVTLWYRAPDVLLGSRTYNTSIDIWSAGCIMAELYTGRPLFPGTTNEDQLIKI
                     FRLMGTPSERSWPGISQLPEYKPNFHVYATQDLSLILPQIDPLGLDLLSRMLQLRPEMR
                     ISAQDALHHPWFRDLPQLQAQLQQQQQQQQQQQQMAGAYGGMVPPQQTY"
     mRNA            complement(3245..4468)
                     /locus_tag="ATCC64974_7850"
                     /product="hypothetical protein"
     gene            complement(3245..4468)
                     /locus_tag="ATCC64974_7850"
     CDS             complement(3245..4468)
                     /codon_start=1
                     /db_xref="InterPro:IPR003000"
                     /db_xref="InterPro:IPR026590"
                     /db_xref="InterPro:IPR026591"
                     /db_xref="InterPro:IPR029035"
                     /db_xref="PFAM:PF02146"
                     /locus_tag="ATCC64974_7850"
                     /note="EggNog:ENOG41; GO_function: GO:0070403 - NAD+
                     binding [Evidence IEA]"
                     /product="hypothetical protein"
                     /protein_id="ncbi_ATCC64974_7850-T1"
                     /transl_table=1
                     /translation="MINQRPSEPSLLEASTSINHVASMTAPAIRIPFTGPLPPPIIVPP
                     SARTVAGAIDALLAFLTAPPSPYLRGVDVGRHSQTVLLTGAGISVASGLSDYRGENGTY
                     ITNKTYRPIYYHEFVARHEFRKRYWARSFIGWPGLLKAKPNSTHWAIKDIGTKGYISSV
                     VTQNVDSFHSVAHPELPTLELHGYLRSAVCINCRTQVPRDEFQQSLERLNPAWAEFLKK
                     MVDIGALNADNPEEQRRRGLKINPDGDVDLPEAPYSTFRYPACPTCLEKPPRLQDGSQS
                     RVEVERDGAWLPSSTAGILKPAVIMFGENIDPAVRLGAEEAIDDAGRLLVLGSSLATYS
                     AWRLVERAYKRGMPIGIINIGGVRNESILFSKAEQETEAVCRHVRCSLPSQDILGPVAA
                     QLPSLTHH"
     mRNA            join(4903..4958,5016..6117)
                     /locus_tag="ATCC64974_7860"
                     /product="hypothetical protein"
     gene            4903..6117
                     /locus_tag="ATCC64974_7860"
     CDS             join(4903..4958,5016..6117)
                     /codon_start=1
                     /db_xref="InterPro:IPR006603"
                     /db_xref="PFAM:PF04193"
                     /locus_tag="ATCC64974_7860"
                     /note="EggNog:ENOG41"
                     /product="hypothetical protein"
                     /protein_id="ncbi_ATCC64974_7860-T1"
                     /transl_table=1
                     /translation="MFPAVTGNIDLEALSGICGSISIACWVVVFSPQIIENFRRGSADG
                     LSLLFLIVWLAGDVFNILGAVLQGVLPTMIILAVYYTLADVVLLAQCFYYRGFTLRDEP
                     SSPPRPVSPITAETYDEDTEIPSPVVPRKPTERTALLTSKQRSASYQAPLDTRSPASSA
                     TITPHHQPLLAHRRHSASSFLHTTVDGTHLSPVTPLVEPAKQPRPPRTLTLLQATFFNG
                     SAIILVCAAGILGWYISQTSSLSSDKNNNNKHKDSPDDLKMDTLGQVFGYLCAVLYLGS
                     RLPQILLNYRRKSTDGVSLLFFLFACIGNLTYVLSILAYSPVCGRSHHGRCRSDELASL
                     YGRYILVNLSWLIGSFGTLLLDMCIFIQFFLYQDANGGEVDAEAR"
     mRNA            complement(join(6691..7281,7337..8134))
                     /locus_tag="ATCC64974_7870"
                     /product="hypothetical protein"
     gene            complement(6691..8134)
                     /locus_tag="ATCC64974_7870"
     CDS             complement(join(6691..7281,7337..8134))
                     /codon_start=1
                     /db_xref="InterPro:IPR007052"
                     /db_xref="InterPro:IPR007699"
                     /db_xref="InterPro:IPR008978"
                     /db_xref="InterPro:IPR011990"
                     /db_xref="PFAM:PF04969"
                     /db_xref="PFAM:PF05002"
                     /locus_tag="ATCC64974_7870"
                     /note="BUSCO:EOG09264LH2; GO_function: GO:0005515 - protein
                     binding [Evidence IEA]"
                     /product="hypothetical protein"
                     /protein_id="ncbi_ATCC64974_7870-T1"
                     /transl_table=1
                     /translation="MNAASLGDTALQQSDPHTATIHYTTALLTHPRSPSYFIKRSTAFS
                     RLKPTPNLSAALRDAESAVLLARERGKRELIVEAQMRRAIVLFLMGRYVAAEGVVGVVE
                     GMIGLDKDGNGGEDKEEKVRKAMGGGAGKGIEAEVRIWGAKIRAKVNGLGEQSGERGEK
                     VEEVPVGVKVPGEKELRGQLEELRGGKVGEGIGGEEKQSQKVEDKVEEKGRAEVKETQQ
                     QQQQQQQQVKVRHEWYQSGETVVVTLYVKGVPKDKVAIELKEDSTSIQFPLPSGAEYDF
                     TLDPLFAPIDPSTSKVSVFSTKIEISLRKKTPGQKWSALESTTGPVISTPQPTVTPTTT
                     TTQAQAPSYPTSSRHGAKDWDKLASSLTQKPKKDKTKSSSKPKDEQGEGEEDDGEASDA
                     ESINSDFGGGDAVDGFFKKLYANADPDTRRAMVKSYVESQGTSLSTNWDEVGQGPVKVR
                     PPSE"
     mRNA            complement(join(8547..8637,8687..10132,10193..10863))
                     /locus_tag="ATCC64974_7880"
                     /product="hypothetical protein"
     gene            complement(8547..10863)
                     /locus_tag="ATCC64974_7880"
     CDS             complement(join(8547..8637,8687..10132,10193..10863))
                     /codon_start=1
                     /db_xref="InterPro:IPR002365"
                     /db_xref="InterPro:IPR008930"
                     /db_xref="InterPro:IPR018333"
                     /db_xref="InterPro:IPR032696"
                     /db_xref="InterPro:IPR032697"
                     /db_xref="PFAM:PF00432"
                     /db_xref="PFAM:PF13243"
                     /db_xref="PFAM:PF13249"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: terpene_cyclase"
                     /gene_kind="biosynthetic"
                     /locus_tag="ATCC64974_7880"
                     /note="BUSCO:EOG09260SIZ; GO_component: GO:0005811 - lipid
                     droplet [Evidence IEA]; GO_function: GO:0016866 -
                     intramolecular transferase activity [Evidence IEA];
                     GO_function: GO:0000250 - lanosterol synthase activity
                     [Evidence IEA]; GO_function: GO:0042300 - beta-amyrin
                     synthase activity [Evidence IEA]; GO_process: GO:0016104 -
                     triterpenoid biosynthetic process [Evidence IEA]"
                     /product="hypothetical protein"
                     /protein_id="ncbi_ATCC64974_7880-T1"
                     /sec_met_domain="terpene_cyclase (E-value: 1e-15, bitscore:
                     52.5, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MSGSHIGPWRTPAQGHLTPDANGDLKTDYTRWRLRDDRGRQTWHY
                     LESDAENEQWPQSIADKYFLGLPTGLPELPKPQTPLQCAENGLEFFSKLQLEPGNWACE
                     YGGPMFLLPVLIITYYVTKTPIPPEYATEIKRYLFARQHPEDGGWGLHIEAHSSVFGTC
                     MNYVTLRLIGVSEDDPRMIKARGLLHQFGGAIYGPHWAKFSLAVLGVMDWECVNPVPPE
                     IWLLPDWVPFAPWRWWIHIRQVFLPMSYLWSKRFSHPLDPLTKQLRQELYTQPYDSIDF
                     AAHRNSIHKADNYYPKTWLLNTLNSLLVNIWNPYLRVPAIVRRAEEWTWELVRMEDENT
                     DYAGLGPVSNPFNMIVCYEHDGPDSYSVRRHRERLHDYMWMKDEGMLMNGTNGVQVWDT
                     AFITQSIVVAGFGDDPKWRPMLTKALEFLEDHQLRENVPDQEKCYRQHRKGAWPFSNKT
                     QGYTVSDCTAEGLRSTIQLQEMHNFPKLISEERLKDSVDCLLLMQNPTGGFTEYETTRA
                     SEKVEWLNAAEVFGGIMIGYDYPECTTASVTALSLFSKYYPNYRAAEIKSAKEKAVQYI
                     KRVQRADGSWYGSWGICFTYAAMFALESLASIGETYETSADSRRGCEFLISKQKEDGGW
                     GESYLSSEKHVYVQHEKSQVVQTAWASLALMEAGYPHKEPLRKAMQLLMSRQQANGEWL
                     QESIEGVFNQSCMISYPNYKLYWPIRALGLYARKFGNEELV"
     mRNA            complement(join(11500..12133,12233..12996))
                     /gene="SFH5"
                     /locus_tag="ATCC64974_7890"
                     /product="Non-classical phosphatidylinositol transfer
                     protein (PITP)"
     gene            complement(11500..12996)
                     /gene="SFH5"
                     /locus_tag="ATCC64974_7890"
     CDS             complement(join(11500..12133,12233..12996))
                     /codon_start=1
                     /db_xref="InterPro:IPR001251"
                     /db_xref="InterPro:IPR011074"
                     /db_xref="InterPro:IPR036273"
                     /db_xref="InterPro:IPR036865"
                     /db_xref="PFAM:PF00650"
                     /db_xref="PFAM:PF03765"
                     /gene="SFH5"
                     /locus_tag="ATCC64974_7890"
                     /product="Non-classical phosphatidylinositol transfer
                     protein (PITP)"
                     /protein_id="ncbi_ATCC64974_7890-T1"
                     /transl_table=1
                     /translation="MADQPEKTAAAPAAPEAQPPTTATTTTEPAVSESQTQPEPQPEAE
                     QKVEQATTGEEASPAPAATEPPVTEPTPAPAQEAPEDKKEEAPKEETKETKAEESKEEQ
                     KAEEPAAEPKAEAAKEEEQKPAQPEYLAKNPALSQFFDRLSAILSSTGHNEMWGVTLKD
                     SSDVPTVNILIKFLRANEGNVKLAEEQLTKALQWRKEMNPLALTEGRYSAERYGGLGYV
                     TKYPEANGKETIVTWNVYGNVKSIDQTFGDVDGFIKWRVALMELAVKDLKLSEATTVID
                     YDGEDPYQMLQVHDYQNVSFLRLNPTIKAASKKTIEVFSMAYPELLREKFFVNVPAIMG
                     WMFAAMKVFLSKNTTRKFHPISNGANLAREFPSLKDKFPKTYGGNGATLEEDAFTVNLE
                     KAEPAPEAPKEEPKEESKQEQAEAPKEEVKEEAKEEAKTEQPAAEEPAKAEAAVTTQEA
                     PAAAEAK"
     mRNA            complement(join(14716..14836,14916..15636,15695..15734))
                     /locus_tag="ATCC64974_7900"
                     /product="hypothetical protein"
     gene            complement(14716..15734)
                     /locus_tag="ATCC64974_7900"
     CDS             complement(join(14716..14836,14916..15636,15695..15734))
                     /codon_start=1
                     /db_xref="InterPro:IPR007062"
                     /db_xref="PFAM:PF04979"
                     /locus_tag="ATCC64974_7900"
                     /note="GO_function: GO:0004864 - protein phosphatase
                     inhibitor activity [Evidence IEA]; GO_process: GO:0009966 -
                     regulation of signal transduction [Evidence IEA];
                     GO_process: GO:0043666 - regulation of phosphoprotein
                     phosphatase activity [Evidence IEA]"
                     /product="hypothetical protein"
                     /protein_id="ncbi_ATCC64974_7900-T1"
                     /transl_table=1
                     /translation="MSHHMEDAHKRPKGILKNSSSQVPQVAQHAHATLTIPSTSADPTD
                     TKELTLQNTLQNAGRRRSSSNTRPGSSSRRQSLASIHGHHDDSSPRLKWDEANLYLTEQ
                     EKTAKMKIDEPKTPYAPRYDPAEDEDELAGEESLIDAQDIVVDELDKTKKAPKKTVAED
                     DIPELELGEAEEYGGDAHMGDADRIVRERSLSNDSHRGGKHVVVGAGELNGETESGGDT
                     LMTAGEAEEKHRQFEQHRKKHYEMRNIKDLLAHPEDLEDEMDEDEDEGDSSSAAVPPPM
                     PRIPERFLNGGK"
ORIGIN
        1 tcagatctca gatctagcct taacctctcc atccatctgc gcagcttcct gtcgaagctg
       61 atgctcactc gtaaactgcg tcgtcgcggc tgcagcaccc tccaaatcag caaccacagc
      121 ctccaacccc gacaacaaac tttcaatctc agacctctgc gcctggacct tctcagccaa
      181 ctccgcattc tgattctgca ccgaattaat cttcgcatcc aaatccgcct gcgtctccat
      241 cagatgcggc aacagatgcg ctttgtacaa ttcctccgga cttaacgtat gcggcctacc
      301 aagcacaaat cattccagtt agccatccat catccacagg cccccaatgt aatgatgcca
      361 aatagcaaaa aaaggaataa ggaaggggag acatacgcaa cactatcccc accgactcct
      421 ctatccttcc taaccttcgc ctccccaacc aaccggtcca actcatttaa ctgcctaaca
      481 gcatccctct cggccagaat atcctcgaac tcggccttcg cgctctcctc caacttcgca
      541 ttcaactgtc tccacacgct ctccaagcta gccgggacat gtttcgccgg cgtcggaaaa
      601 cacccgctga aattcgcata cgagttcgcg cgcagcgtgc gcgcgagcgc cttgtcgaaa
      661 atctcttgta gtttggaggc gcgcgggcct ggtgttaggg ggaccggcgc gggaggaggt
      721 ggtgaggggg aggcgcctgg tctttgggct gatgggttgg gttcggtgga catgttttct
      781 ttcgccggtt gagggtttga ggtggttgaa gagtttcgat tggggtgcag tgatttgtta
      841 tgctgagcct taagttcgtt tcaagctcct ttgtgttgtt gttgttcgtg gttgtaggat
      901 tatggagaat agtagattga tgatgggatt ggaggacgcg ccggaagacg cgcgcgacta
      961 ttaatcacgt gatagatata gatcccgcca gaagaccgga gtacctacat atattacaga
     1021 gtttaggtac ctataaagta agatgtgtag gctactgtat atttgtagtg tttaaatcag
     1081 tttgaaaaat ataaggatgg tccttattgt aagttgtctt ttcgtggcga gccgagatta
     1141 gctactgtgt tcaacttggt tgcgtggaat gttagggctt atatccggca ctgataaagg
     1201 cttgtcagga ttgatttagt tgtctgcggg acaagatatc gtcgctgctg tccctgcgct
     1261 tgtaataagc tacgataatg gaaggtaata gagagcaata gataagtata atggccaagt
     1321 ttatctacga gatgccatcg gttctctggg tccatatgca acgcaaagaa agcagaaaac
     1381 agcaagaatc attcgaatgt cctctcagga gtcaaacgcc gcgctcccca ttctaaaacc
     1441 gaatccgttg ctcgtcaagc cttccacgag gaagcagatg aacgcaagtc aaggtaaacg
     1501 ataggctgta catgatgaaa acgaactata aggaaaacag aaacgcatca aaggaagaac
     1561 tcaatatgtt tgctgtgggg gaaccatgcc accatacgcc ccagccattt gttgttgttg
     1621 ttgctgctgc tgctgctgtt gctgcaattg ggcctgcaat tgcgggagat cgcggaacca
     1681 ggggtgatgc agggcgtcct gggcactgat ccgcatctct ggccggagct ggagcatccg
     1741 gctcaagaga tccagaccta gggggtcaat ctgggggaga atgagactga gatcctgcgt
     1801 cgcatatacg tggaagtttg gcttgtactc cgggagctgg gagatgccgg gccatgagcg
     1861 ttccgaaggg gttcccatca ggcggaagat cttgataagc tggtcttcgt tggtggtgcc
     1921 agggaacaga ggacggccag tgtagagttc cgccatgata catccagcag accagatgtc
     1981 gatgctcgtg ttgtatgtgc ggctgcccag aagcacatct ggggcacggt accacaaggt
     2041 cacgacttcg ttggagaaag tattgacggg aatgccaaag gcgcgggcta gaccgaaatc
     2101 tccaagttta agttgtccct tcttgttgat gaggaggttt tgaggcttca gatcgcggtg
     2161 gaggacgcgg ttctcatggc aaaacgcaat gcccttgaga agctggtgca tgaatgacat
     2221 gattgtggct tggtccaact ggccgcggtc ggcgcgggta tccatgtact tcttcagatc
     2281 cttgtccatg tactcaaaga cgagcatgag tttgttctcc gtgtgaatca catcatagag
     2341 cgacacgatg ctctcgtgct tcagctcctt catcaacgat atttctcgaa tggcggtgga
     2401 tggcgttccc tcttcagaat cgagatggat ctctttcagg gcgaccagct cgccagtctg
     2461 gcgattgcgt cccttgaaga cctgcgagag ggtgtcagta catagtgcga tttaagagga
     2521 tcggccgtgc ggagggaggg gttcgtacgg tggcataggt gccttctcca agctagaatc
     2581 agcagttagc atcacaaatc tctcatttga tgggtgatat cttggtagac agtagggaag
     2641 ccatcaaaac acaccttttc cagctgctgg aacgagctgg gctgctgctt gtccatggtg
     2701 gtcgatggtg cgacggtggt actctgcgca gcaggagttg gatgagaacg agaggtggag
     2761 cgtgggggat gaaagagaaa agtcttggga gaggccaagt tagagatgag atccagataa
     2821 tcggcggttg gaggttgcaa tgtcctgctt tttgagcggt cgcgaccgtc catgtccatg
     2881 ctgatctgaa ccggcgaatg cagagccccg cgctggaatc gaacagcgga cgggcggctg
     2941 actggcccgc catcactttg taactcgcct tctcctactt tgctggtctc cactatcccg
     3001 gcgtctatta catgcctatc ttagctcgcc gttgccaatc attctggagt gcctataatt
     3061 atcttttcta gagtattcca tctgatggat acagttactt tgaaaatagt aacgtctcca
     3121 ataatgcaag cttggattca acttttatcg cttgtacata tactatgatg cttatctgta
     3181 agcggttcat acacctcacc gccatctata catcacatcc tttttttcaa tctatacatg
     3241 gaccctaatg atgagtaagt gaaggcagtt gtgctgccac agggcctaga atatcctggg
     3301 acgggagact gcaacggaca tgccggcata cagcctccgt ctcttgttcc gccttgctaa
     3361 agaggatcga ctcgttccgg acacctccta tgttgatgat gccaatcggc atccctcgtt
     3421 tataggccct ttccactagg cgccacgccg agtatgtggc gagactgctg cccaggacaa
     3481 ggagcctgcc cgcatcatcg atggcctctt ctgcacccag cctgacagct gggtcgatat
     3541 tctctccaaa cataatgacc gccggcttca gaattcccgc cgtagaactt ggaagccaag
     3601 ccccatcgcg ctctacctcc acacgggatt gggacccatc ctgcaatcgg ggtggcttct
     3661 ccaagcacgt cggacatgct ggataccgaa aggtcgaata aggggcctcc ggtaaatcta
     3721 catcgccatc cgggttgatt ttcaagcccc tccgtctctg ctcctcaggg ttgtctgcgt
     3781 tcagcgcgcc aatatcgacc attttcttga ggaactctgc ccaggcgggg ttcagccgct
     3841 cgagcgattg ctggaactcg tctcgcggga cttgagttcg acaattgatg cagacggcag
     3901 aacgcaagta gccgtggagt tcgagtgtgg gtagttctgg atgcgcgaca gaatggaagg
     3961 agtcgacatt ttgcgtcacc actgaactaa tatagccttt cgtaccaatg tctttgatag
     4021 cccagtgcgt cgaatttggc tttgccttta ggagccccgg ccacccaatg aagcttcgcg
     4081 cccagtatcg cttgcggaac tcatggcgag cgacgaactc gtggtagtag atcggccgat
     4141 acgtcttatt tgtgatgtac gtgccattct caccccgata atcggacagg cctgaagcta
     4201 ccgagatacc agcgcctgtc aagagcactg tctgggaatg cctgcctaca tcaacgccgc
     4261 gcaggtacgg cgacggtggg gccgtcaaaa aggctaaaag cgcatcaatg gcacctgcga
     4321 ccgtgcgagc ggacggaggg acaataatcg gcggaggcag agggcccgta aagggaatcc
     4381 gaattgctgg agcagtcatt gaagccacat gattgatgga tgttgaagct tcgagaaggc
     4441 tgggttcaga tgggcgctgg ttgatcatcg acgtcacggc ttgactaatc ggtcacatga
     4501 tgtacacagt cccattgagt gtgaaatgga tggtcagact acacggggcc aagtattact
     4561 tgatcagata gtaatagatg accagaaggc ccagaatgta cgatacagag cattgcggcc
     4621 gacaaggaac aaagcgtccc cagccaaaag aagtaaaagt ggaagcaagt cgatctgggt
     4681 gtccattctt ggtctagact gagaggagct accccggatc gtcccacgtg atctgcaccc
     4741 ttcgcagact ctgcgaacgt catcgccggc catctgcttc attccatcaa cgcgtctttg
     4801 tttgctgtcg accagttttg ctagcctctt cctgtttaga ttatagagta gagcattgat
     4861 tgggaaaacg cccaatcgct ctctcgttcg caccgcccgg acatgtttcc cgcagtcacc
     4921 ggcaatatag atctagaggc actgagtggc atatgtgggt atgtttatgc cagagtatgc
     4981 tagaattgga catgttcaat actgatcact gatagatcca tctcgattgc gtgctgggtg
     5041 gtggtcttct ccccacagat cattgaaaat tttcgtcgcg gctcagctga tggcctttcg
     5101 cttcttttcc tcatcgtctg gcttgccggc gatgtgttca acatcctcgg tgccgtcctg
     5161 cagggcgtcc tgccaaccat gataattctc gcggtgtact acactttagc cgatgtggtg
     5221 ctcttagcac aatgcttcta ctatcgggga ttcacactgc gcgacgaacc atcctcgccg
     5281 ccgcggcctg tctctcccat cacggcagaa acttacgacg aggacactga gattccctcc
     5341 cctgtcgtgc ctcggaagcc cacagagcgc accgcgttgc ttacctccaa acaacgcagt
     5401 gcctcttacc aggctccttt ggacactcgt agcccagcat catcggctac catcactcct
     5461 caccaccagc ccttgctcgc ccatcgccgt cactccgcct cttcatttct tcatacgacc
     5521 gtcgacggaa ctcacctctc cccagtgact ccactcgtcg aaccagccaa gcaaccccgt
     5581 ccccctcgaa ccctaacact gctccaagcc accttcttca acggttcggc catcatcctc
     5641 gtctgtgccg ccggcatcct gggctggtac atcagccaaa cgtcatcact ctcatcggac
     5701 aagaataaca acaacaagca taaagacagc cctgatgacc tgaaaatgga cacactaggc
     5761 caagttttcg gctacctctg cgcagtcctg tacctcggtt cccgcctccc acagatcctc
     5821 ctcaattatc gccgcaagtc aacagacggt gtttccctgc tgttcttcct cttcgcctgt
     5881 atcggcaatt tgacctacgt cctttccatc ttggcgtatt cgcctgtgtg tggacgctcg
     5941 catcatggtc ggtgtcgatc tgatgaactg gcatcgctgt atggtcgata tatcctggtc
     6001 aatctgtctt ggctgattgg gagctttggc acgttattgc tggatatgtg tatctttatt
     6061 caatttttct tgtaccagga tgcgaatggg ggtgaggtgg atgcagaggc gaggtaaaat
     6121 atttgcatgt ggtttacatt ctctcttgtt tattcttgtt tttcttgatt atgcctctgg
     6181 gaagacataa agaggtgtcg gtgttggtac ttagggattg cttgatttat aatgatttat
     6241 cctaaaaacg cttgcgtgct atatggccag gttgctatgc tactcttgct catgtgattg
     6301 gcgcttggtg ggatcggagt tgcttttcgt gtatataatt atttattatc ttatactata
     6361 ctcgcttcta cattacgtgt ataatgtagt agtctacgta tcatgtttac aaggtaagta
     6421 atagcagagt ctcgacatct cgcaatgatt accattacac aagtaaagca gagctaagct
     6481 aaggctaagc tacacaaaac aagtaactag caaggaaagc aacttcagaa cctaaaacac
     6541 cacccacatg cacccacaac atggatgtag accataactc cacgcttgca attcgcatac
     6601 ccccttcttc tccatctttc aaccaacaat tctttcttgc tcccctcttt cctttctctc
     6661 agaaactgag aaagaaaaga agaaagaaaa tcactcacta ggcggcctaa ccttaaccgg
     6721 cccctgccca acctcatccc aattcgtact cagcgacgtc ccctgactct ccacgtaact
     6781 cttcaccata gcgcggcggg tatccgggtc cgcattggca tagagtttct tgaagaagcc
     6841 atcgacggca tcaccgcctc cgaagtcgga gttgatggat tcggcgtcgg atgcttctcc
     6901 atcgtcttct tctccttctc cttgttcatc cttgggcttt gagctgctct tggtcttgtc
     6961 ctttttcggt ttctgggtta ggctggaggc gagcttgtcc cagtctttgg cgccgtggcg
     7021 ggaggaggtg gggtatgatg gggcttgggc ttgtgtggtg gtagtggtgg gtgtaaccgt
     7081 gggctgggga gtagagatga caggtccggt ggtagattcc agggcgctcc atttctggcc
     7141 gggagttttc ttgcgcaggg agatttcgat ctttgtggag aagacggaga ctttagaggt
     7201 ggaggggtcg atgggagcga agagcgggtc gagagtgaag tcgtattcgg cgccggaggg
     7261 gagggggaat tggatggatg tctatgtata taggttagtg acttgcatgt ttgagtcaag
     7321 gggagtgaat acataccgag tcctctttca gctcaatagc cactttatcc ttgggcacgc
     7381 ctttcacgta aagcgtcaca acaaccgtct caccggactg gtaccattca tgacggacct
     7441 tgacctgctg ctgctgctgt tgttgctgct gctgagtctc cttgacctca gctctcccct
     7501 tctcctccac cttatcctca accttctgac tctgcttctc ttcaccacca ataccctcac
     7561 caaccttccc tcccctcaac tcctccaact gtcccctcaa ctccttctcc cccggcactt
     7621 taacccccac cggaacctcc tccaccttct ccccacgctc accactctgc tcgcccaaac
     7681 cgttgacctt cgccctaatc ttcgcccccc aaatcctcac ctccgcctca atacccttcc
     7741 cagcaccacc ccccatcgcc ttcctcacct tctcctcctt atcttcccca ccattaccgt
     7801 ccttatccaa tccaatcata ccctccacca cgcctaccac cccctccgca gcaacgtatc
     7861 tccccatgag aaacaaaacg atggctctcc gcatctgcgc ctcgacgatc agctcgcgtt
     7921 tcccccgctc gcgggcgaga agaacggcgg attcggcatc gcggagggcg gcggagaggt
     7981 tcggtgtggg ctttaggcgt gagaaggctg ttgagcgttt gatgaagtag ctgggcgagc
     8041 gggggtgcgt gaggagggcg gtcgtgtagt ggattgttgc ggtgtggggg tcggactgtt
     8101 ggagggcggt gtcgccgagg gaggcggcgt tcattttgag gttttgaggt ggtgggttgg
     8161 agtgtggtgg tgtttggatg gaggtgttgc gttgtgctgt gttgtgttgt gtttgttggg
     8221 tgggtagata gggtttaagt atgggtctga gtacgagatg tgaaaaatga gtcttgttgt
     8281 ttgtaaggga atctccgaag agaaaaggaa ataatgtgta agagaaagag gaatacaagt
     8341 ggagaggtga atggaatgga aacaagttcg atgatcttct ttggagagat gcggggagcg
     8401 gagcatccac gtgattggct acacatctaa actctccaga tcaacgataa agaagatagt
     8461 atacatgaat catattatca attagtagaa ggttatagta gtatagtagt aatacatgta
     8521 ctcatagaag aacaattcat agaagatcag accaactcct cattgccaaa cttgcgcgca
     8581 tacaatccca acgcccggat cggccagtac agcttatagt tgggatacga aatcatgctg
     8641 tcactcgtta gtggagaact ctcaatcaat cgatcatgat actcaccaag attggttaaa
     8701 cactccctca atcgactcct gcaaccactc tccattggcc tgctgccgcg acatcagcag
     8761 ctgcattgct ttccgcagcg gctccttatg cggatacccg gcctccatca atgccagact
     8821 ggcccatgcc gtctgcacga cctgcgattt ctcgtgctgc acatagacgt gcttctcgct
     8881 gctgaggtac gactcgcccc agccgccgtc ctccttttgc ttcgagatga ggaactcgca
     8941 tccgcgtcgg gagtccgcgc tcgtctcgta cgtctctccg atgctggcca aactctccag
     9001 ggcaaacatc gccgcgtacg tgaagcagat gccccaggac ccgtaccagc tgccatcggc
     9061 gcgctgcacc cgcttgatgt actgaacggc cttttccttg gcggacttga tctctgcggc
     9121 ccggtaattc ggatagtatt tgctgaagag ggagagcgcg gtgacggacg cggtcgtgca
     9181 ctcgggatag tcgtatccga tcatgattcc gccgaatacc tcggctgcgt tgagccactc
     9241 gactttctcg gatgcccgcg tggtttcgta ctcggtgaac ccaccagtgg ggttctgcat
     9301 caggagcagg cagtcgacgc tgtccttcaa tcgctcctcc gagatcagtt tcgggaagtt
     9361 gtgcatctcc tgcagctgga tggtcgagcg cagtccctcg gcggtgcagt cgctgaccgt
     9421 gtatccctgc gtcttgttgc tgaatggcca tgcgcccttg cggtgctggc ggtagcactt
     9481 ctcctggtcc ggcacgttct cgcgcagctg atggtcttcc aggaactcca gtgccttggt
     9541 gagcatgggc cgccatttcg ggtcatcgcc gaacccggcc accacgatac tctgcgtgat
     9601 aaaggccgta tcccatacct ggacgccgtt ggtgccgttc atcagcatgc cctcgtcctt
     9661 catccacatg tagtcgtgca gccgttcgcg atggcgacgg accgagtagc tgtccggacc
     9721 gtcatgttcg tagcacacaa tcatgttgaa cgggttgctc acaggcccca ggccagcgta
     9781 gtcggtattc tcgtcctcca tgcggaccaa ctcccacgtc cactcctccg cgcgacgcac
     9841 aatggcaggg acacgaaggt aggggttcca gatgttgacg agcagagagt tcaaggtatt
     9901 cagcagccaa gtcttggggt agtaattgtc tgccttgtga attgagttgc gatgcgccgc
     9961 aaagtcaatc gagtcatacg gctgggtata cagctcctgc cgcagctgct tggtgagagg
    10021 gtccaaggga tgcgagaacc tcttagacca cagatacgac atgggcagaa atacctggcg
    10081 aatatgaatc caccagcgcc agggcgcaaa cggcacccag tcaggaagta gcctggtcga
    10141 atcagtatcc catccacaaa tcacccacta gacatgatag aaacaaacgt accaaatctc
    10201 cggcggcacc ggattcacac actcccaatc catcacaccc aagacagcca gcgagaattt
    10261 cgcccaatgg ggcccataga tggcacctcc aaattgatgc aacaaccccc tggccttgat
    10321 catcctagga tcatcctcgc tcacaccgat taacctcaac gtaacataat tcatacaagt
    10381 accaaacaca gaactgtgag cttcaatatg caacccccag ccgccatcct caggatgctg
    10441 cctagcaaac aaataccgct taatctcggt ggcatactcc ggcggaatag gcgtcttagt
    10501 aacatagtac gtgataatca agacaggcag caagaacatg ggcccgccat actcgcacgc
    10561 ccaatttccc ggctccagct gcaacttgga gaagaactcc agcccgttct cggcgcattg
    10621 cagaggcgtc tggggtttgg ggagctcggg aagtcccgtg gggagaccca agaagtactt
    10681 atctgcgatg gattgaggcc attgctcgtt ctctgcgtcg gattccaggt agtgccaggt
    10741 ttggcggccg cggtcgtcgc ggaggcgcca gcgcgtatag tcagttttga gatcgccgtt
    10801 ggcgtcgggg gtgagatggc cttgggcggg agttctccac gggccgatgt gagatcccga
    10861 cattgtgatg gggggttgtt gtacacttat ggtattgggg gggggggggg gggggggggg
    10921 ggggggttga aagggtggaa tggcagggtt gagattagtg gagagaggga tagtgggagg
    10981 gatagcttat aggatacaac cacactcgag aggagagaaa ggaagaacaa cacactaatc
    11041 tcccttgccc ggattttatt tgctgcctgt tgttcgtgca gcagctgtgc agttggtgtt
    11101 tttgttggtg caggaaactg agggacactg gctgctgagt catcaggggt gcctggctgg
    11161 agatcagcat aaagagagca ggaaatccag tgttatagtt tactgctgca tgcaggaacg
    11221 catggaataa cggtcgacgc gagagaaaca tcgtaacgtt aaatcagcgg ctatatgacc
    11281 tgttacatta aatattacta tctagtgttt ctgcactcca tcatcaatcc cagaacatat
    11341 aaagcacaca ctatcgagag gtatcaagta cgcaaaacga cacggaatca ttctaccgat
    11401 tcccccgggt atcaatccaa cctgtcccat ccattaccgt aaattatgtg atcctggcct
    11461 cattccgacc aggtgtgaat tacgcctctt gctagctttt tatttggctt ccgctgcggc
    11521 gggcgcctcc tgggtcgtca ctgcagcctc tgccttggcc ggctcctcgg ccgccggctg
    11581 ctctgtcttg gcttcctcct tggcctcctc ctttacctct tccttgggag cctcggcctg
    11641 ctcctgcttg gactcctcct taggctcctc cttgggagcc tccggggcag gctcggcctt
    11701 ctcgaggttg accgtgaacg catcctcctc cagggtcgcg ccgttaccac cataggtctt
    11761 ggggaacttg tccttcaggg aagggaactc gcgggccagg ttggcaccgt tggagatggg
    11821 gtggaacttg cgggtggtgt tcttgctgag gaagaccttc atggcggcga acatccagcc
    11881 catgatggca ggcacgttga cgaagaactt ctcccgcagc agctcggggt aggccatgga
    11941 gaacacctcg atggtcttct tgctggccgc cttgatggtg gggttcagcc ggaggaagct
    12001 gacgttctgg tagtcgtgga cctggagcat ctggtacgga tcctcaccgt cgtagtcgat
    12061 cacggtcgtc gcctcactca acttcaagtc cttgacagcg agctccatga gcgcgacacg
    12121 ccacttgatg aacctaggcg acagttagat ctaaccctct tttcaattcc gaaatagcag
    12181 caacagcagc agcaacagca gcagcagcag cagcagcagc agcagcactt acccatctac
    12241 atcgccaaag gtctgatcaa tagacttgac attaccatag acgttccaag taacaatggt
    12301 ctccttgcca ttcgcctcgg ggtacttggt gacatagccc agaccaccat agcgctcagc
    12361 actgtagcgg ccctcggtca gggcgagggg gttcatctcc ttgcgccatt gcagggcctt
    12421 agtcagctgc tcctcggcca gcttgacatt accctcgttg gcgcgcagga acttgatgag
    12481 aatgttgacg gtggggacat ccgaggagtc cttgagggtg acaccccaca tctcattgtg
    12541 gccagtggag gagagaatgg cagacagacg atcgaagaac tggctcaggg ccgggttctt
    12601 ggccagatac tcgggctgag cgggcttttg ttcctcctcc tttgctgctt cggccttggg
    12661 ctcagccgcg ggctcttcgg ccttctgctc ctccttggat tcctcagcct tggtctcctt
    12721 ggtctcttcc ttgggtgctt cctccttctt atcctcgggg gcctcctggg cgggagcggg
    12781 agtgggttcc gtcacgggag gttccgtggc agcgggggca ggagatgctt cttctcctgt
    12841 cgtcgcctgc tcgacttttt gttcggcttc tggctgaggt tcaggttgag tctgagactc
    12901 cgaaaccgca ggctcggtag tagtagtggc ggtggtgggg ggttgcgcct cgggggcagc
    12961 aggagcggcg gcggtctttt cgggctgatc ggccatgatg gatgtagtgg gatgtattat
    13021 ttggtagcag tagattagtg aaagatagag agaggggaaa taagaattaa aatgaatgta
    13081 tggaattgcg tgatgcgatc ggacgcgagc gggatggctt tccaataaca gccgtggaaa
    13141 tgaacagcag gggagaaaaa gagagagaga gagagagaga gagagagagg aagagaaaag
    13201 aggaagagga gaagagaaga aaaacacgag agaccagaaa agacagaaag cgcgaaagaa
    13261 acgaagcgaa gcgacaagca ggcaaagacg aaactaagaa agcacagaaa acgcgcgcaa
    13321 tccaatcaga gatagcagtg gattaattaa ttaattgctg cagcggccgt taatttcaat
    13381 taggaggttt caacggcgat cagacaagac aactaactga tttgttttat ttatctatcg
    13441 atttctctgt catctggaag gtttcagacc agatccagag tagaccaaac aaacaactta
    13501 aaatatggat ccatcccatg gttgaaaagt catataccat gactcttcac tactagatga
    13561 tagtagaact cagcacaaac cttatacttg attcaacatc tgatccattg agtggaagtg
    13621 aaggaaggca cacacacaca cagagtacat agctagtact ccgtagtaca gtagaataac
    13681 taactaacca agttactcag aatagcaact cgactaggaa accgaaaatg atccatccca
    13741 tcctcctgaa tcttggagtg ggcctgcaag gatgtttcag gagagagaga gaccgacaga
    13801 cagactcacc aagaaaaatc ccagaatgcc cctgacaggt tacagcatgc ggtgactgat
    13861 cacatccact cacttcctcc agatgacatg caaggcaccg actcgagggt tggttgagat
    13921 gccgactctt ggattctgat actataatta ttcttcttgt ctcaggtggt cggatgattt
    13981 gacagcctcg ggcttagcgg agaggcgcgt gctctaactc actattactc agagtagtct
    14041 ggccgcggac tcaaggtgac tacttatcac cttctctaat ggcattggtt ccctattttt
    14101 tttttttttt ctttcttttt ttttttttta tcttctatgt tggtttgatt cggtttacgg
    14161 agtacttccc agagtattgg atgattctat tttttgacgc gactcatata accccgaggg
    14221 tgacgagtcc cccctggcct gctgtggtca gacaaacagt ctagaactct ccctgcttcg
    14281 ggtgggttat ttccctgaca gctagctcat ttacttcatc gtatctagtt tttaaacaag
    14341 acgtgtcaat aatccataac tctctcccct ccccgtacat ttcattttca tctctctcgt
    14401 ctatcaatcg atcaagcaac ccatcgttcg ctatgagaga aaaaaaagag ccgacacaat
    14461 ccacatcagc tagcaggaag agtgaacaac tagagaagaa gaaaaaaaaa aaaaaaaaag
    14521 caaagtactt cccatagatt catacaagtc cgtcccatca tgactaaaca acgctgggga
    14581 atatacagag tccgtttatg cagcaagaat caactagtcc ctccctccat cctattttcc
    14641 tatcacctct tctcgtccta atccttctcg agtagagtga taacttagtc ccgtccgtcc
    14701 attcctttcg ctccctcact ttcctccatt tagaaatcgc tccgggatcc taggcatcgg
    14761 gggcggcacc gcggcacttg agctgtcccc ctcatcttcg tcttcgtcca tttcgtcctc
    14821 gagatcctca gggtggctgg aaaacaaagc ccgtcagtat accatacctc catgagaaat
    14881 cccacagcca tcctgggaat aggggagcaa cttacgcaag gagatccttg atgttccgca
    14941 tctcatagtg cttcttccga tgctgctcga actggcgatg cttttcctcg gcttcgcccg
    15001 ccgtcatcaa cgtatctcca ccagactcgg tttcgccgtt cagctcgcca gccccgacca
    15061 caacgtgctt cccgccccga tgtgagtcat tgctcaagct tcgttcgcgc acgatccgat
    15121 cggcatctcc catatgcgca tcaccaccat actcctcggc ctctcccagc tccaactccg
    15181 gaatatcgtc ctctgcgacc gtcttcttgg gcgccttctt cgtcttgtcc agttcgtcca
    15241 ccactatatc ctgcgcatca atcagacttt cctcgcccgc cagctcgtcc tcatcctcgg
    15301 cggggtcata gcgcggcgca tagggggtct tgggctcatc gatcttcatc ttggccgtct
    15361 tctcctgctc cgtcaaatac aggttggcct cgtcccactt caggcggggc gacgagtcgt
    15421 cgtgatgacc gtggatgctg gcaagagact gtcgtcgcga cgaagacccg gggcgagtgt
    15481 tggatgacga ccgacgtcga ccggcattct ggagggtgtt ctgaagcgta agttccttgg
    15541 tgtccgtagg gtcggccgag gttgaaggga tcgtcaaagt agcgtgagca tgctgcgcga
    15601 cctggggcac ctgagagctg gagttcttca gaatacctgc tgtccgatta gcaaccaggc
    15661 gtaggatgcg gatgatcgca agaggtttgt ttacccttgg gtcgcttgtg tgcatcctcc
    15721 atatggtgag acat
//
