LOCUS       OGUI01000014.1         23081 bp    DNA     linear   PLN 19-AUG-2019
DEFINITION  Aspergillus niger.
ACCESSION   OGUI01000014
VERSION     OGUI01000014.1
KEYWORDS    .
SOURCE      Aspergillus niger
  ORGANISM  Aspergillus niger
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Eurotiomycetes; Eurotiomycetidae; Eurotiales; Aspergillaceae;
            Aspergillus.
COMMENT     'Annotated using funannotate v1.6.0-df4262f'.
            ##antiSMASH-Data-START##
            Version      :: 5.0.0
            Run date     :: 2020-11-02 07:37:12
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 213400
            Orig. end    :: 236481
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..23081
                     /aStool="rule-based-clusters"
                     /contig_edge="False"
                     /core_location="[223400:226481]"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..13081
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     cand_cluster    1..23081
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..23081
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="4"
                     /rules="(Terpene_synth or Terpene_synth_C or phytoene_synt
                     or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps
                     or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /tool="antismash"
     mRNA            complement(join(230..468,519..744))
                     /locus_tag="ATCC64974_83050"
                     /product="hypothetical protein"
     gene            complement(230..744)
                     /locus_tag="ATCC64974_83050"
     CDS             complement(join(230..468,519..744))
                     /codon_start=1
                     /db_xref="InterPro:IPR000999"
                     /db_xref="InterPro:IPR036389"
                     /db_xref="PFAM:PF00636"
                     /locus_tag="ATCC64974_83050"
                     /note="GO_function: GO:0004525 - ribonuclease III activity
                     [Evidence IEA]; GO_process: GO:0006396 - RNA processing
                     [Evidence IEA]"
                     /product="hypothetical protein"
                     /protein_id="ncbi_ATCC64974_83050-T1"
                     /transl_table=1
                     /translation="MPSFSALAERAQALQNLIGYIFNDPKRAMEALVAAGVYMPGLINR
                     TDGHKQLALVGDAVLRMVLALDGYEARKGREFTNNILSTKAGNTYIAQAGRNLGLDKLV
                     IVNPAQAGMVSDKVMASAVEAIIGAVFMDSDGSVESVRPVLTILGLGWPA"
     mRNA            complement(4772..5947)
                     /locus_tag="ATCC64974_83060"
                     /product="hypothetical protein"
     gene            complement(4772..5947)
                     /locus_tag="ATCC64974_83060"
     CDS             complement(4772..5947)
                     /codon_start=1
                     /locus_tag="ATCC64974_83060"
                     /note="SECRETED:SignalP(1-19); EggNog:ENOG41"
                     /product="hypothetical protein"
                     /protein_id="ncbi_ATCC64974_83060-T1"
                     /transl_table=1
                     /translation="MSIQGFIVAAGFLLGRVAAITPAASSPVASSQAYVPSVSCRTQLG
                     TNSVALVPTTTITRTIHDPTPVVVFSTTQDTVTVTPDASTVTVTDYETTTAISTADTVT
                     DTFSTTSTEYDTATVTITPAAVTAIVSVTISTTSTSTSTIASSSGFSPIVETLPTATAA
                     KRSLIEQDDCSSWLDDYQYPQEVECHQKILVKTTTVSTVTQSPATATAVTPTSTVTVTN
                     TITSTSVVAPSDVSTTLSYSTTSTITETTTAAAETTTVTSTTSAVAAVATTTFYEACGS
                     SNIAGDPLSSGFGSFAGQYMYLVTFTNVPGESLTVGDTSSAYDCCVSCMESSTCAMSYY
                     NAVTSSISYCYLIHTTTCSQSSVYAKASVHDASTTMQMSNGNCGRVVGVQG"
     mRNA            join(6608..7124,7183..8465)
                     /locus_tag="ATCC64974_83070"
                     /product="hypothetical protein"
     gene            6608..8465
                     /locus_tag="ATCC64974_83070"
     CDS             join(6608..7124,7183..8465)
                     /codon_start=1
                     /locus_tag="ATCC64974_83070"
                     /note="EggNog:ENOG41"
                     /product="hypothetical protein"
                     /protein_id="ncbi_ATCC64974_83070-T1"
                     /transl_table=1
                     /translation="MHTQFFVVCSFFEGSNSYSINHRGTLVECSPLTLYLACKGIANSQ
                     FKAGTQSFSSSPPALDLCIPAFTSAKPVFGFVQSNSELFTPCPQTIWNHIQRSSRANPC
                     WGRISSVEHFHILVSCNIRRVFHTAVNYVGGPLYSYGHNYCMPICSPRLSSTLENNPCH
                     HRDHCGVHHTTDTAVNNGHGSGGAELTTSTVFSTRTATITACPSSVTNCPLRSKTTYVT
                     TETLVVSTTVCPVADITGSSGAVIATQSASHPSASVAVGDNWSSMGGFDITTSTILSTR
                     VITVTACPSSVTNCPMRSKTTYASTETLVVATTVYPVPKVSNTKAKTPLPSVTRASEEG
                     PSLTTSTILSTRIATVASCTGDDCRSSSSDSYVTTETLVVGTTVYTVYPEYVSVPTEGV
                     DAMAAPTTAATLLQTANSAGSSPKVVSSGSQPTSASETSTQGTGSSAGSSAESSEGSDA
                     GSAADSSAVSGAGSGAAADTTYTTTIIVESCSNDGTCTEYGSTITMAQTSNLAQPTVPP
                     SPYSYTSYLGSGLGWNHSTPVSSAHVWPQSSHQAGMSTAMVTSTRSASAVNALYTGSAS
                     AGSQWSMLQVVGMAVAILTAVLV"
     mRNA            join(10001..10327,10382..10734,10790..11117)
                     /locus_tag="ATCC64974_83080"
                     /product="hypothetical protein"
     gene            10001..11117
                     /locus_tag="ATCC64974_83080"
     CDS             join(10001..10327,10382..10734,10790..11117)
                     /codon_start=1
                     /db_xref="InterPro:IPR000092"
                     /db_xref="InterPro:IPR008949"
                     /db_xref="PFAM:PF00348"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: fung_ggpps2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182:Polyprenyl synthetase (Score: 89.2; E-value:
                     4e-27)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ATCC64974_83080"
                     /note="GO_process: GO:0008299 - isoprenoid biosynthetic
                     process [Evidence IEA]"
                     /product="hypothetical protein"
                     /protein_id="ncbi_ATCC64974_83080-T1"
                     /sec_met_domain="fung_ggpps2 (E-value: 2.5e-115, bitscore:
                     377.9, seeds: 17, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MEPLQHHLPQTSLAFLALLAVPITALVWDRILNPLPTTKRAWLVG
                     KKQPSRITSLECPYSYIRQIYGKHHWAPFVDKLAPSLKLEDPPKYQLVLEIMDGIHLCL
                     ILVDDISDGSNFRKGHPAAHKIYGPSETANRAYYRVTQLLNRTVHEFPRLAPFLMQCLE
                     EILEGQDMSLVWRRDGLASFPVGPKERDAAYRQMASLKTGALFRLLGQLVLENKSMDAT
                     MTTVAWCSQLQNDCKNVYSTDYAKAKGALAEDLRNGELSFPIVVALDAPEGHLIARALE
                     YGSPHNIRNALRVIQREDVRSACLWDLKKSSASVQDWLEVWGRKEKMDVKSVKP"
     mRNA            join(11861..12034,12085..12239,12309..12614,12703..13081)
                     /locus_tag="ATCC64974_83090"
                     /product="hypothetical protein"
     gene            11861..13081
                     /locus_tag="ATCC64974_83090"
     CDS             join(11861..12034,12085..12239,12309..12614,12703..13081)
                     /codon_start=1
                     /db_xref="InterPro:IPR000092"
                     /db_xref="InterPro:IPR008949"
                     /db_xref="InterPro:IPR033749"
                     /db_xref="PFAM:PF00348"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: fung_ggpps"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: fung_ggpps2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182:Polyprenyl synthetase (Score: 227.6; E-value:
                     3e-69)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ATCC64974_83090"
                     /note="GO_process: GO:0008299 - isoprenoid biosynthetic
                     process [Evidence IEA]"
                     /product="hypothetical protein"
                     /protein_id="ncbi_ATCC64974_83090-T1"
                     /sec_met_domain="fung_ggpps (E-value: 3e-141, bitscore:
                     463.2, seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="fung_ggpps2 (E-value: 4.7e-96, bitscore:
                     314.7, seeds: 17, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MLGFPMFSPETPDAWKMNTPYFPFVSSGVFSASIPSSPTNIEAAS
                     TSQSETSFLDKEKIVRGPLDYLLKSPGKDIRRKFIHAFNEWLRIPEEKLNIITEIVGLL
                     HTASLLIDDIQDNSKLRRGLPVAHSIFGIAQTINSANYAYFLAQERLRELNHPEAYEIY
                     TEELLRLHRGQGMDLYWRDSLTCPTEEDYIEMIANKTGGLFRLAIKLMHDVIELADLLG
                     VIFQIRDDYQNLQSGLYTKNKGFCEDLTEGKFSFLIIHSIHSNPNNHHLLNILRQRSED
                     DSVKKYAVEYIDSTGSFEYCRERLASLLEEADHMVKELESQVGHSKGIYEILSFLS"
     mRNA            14093..15676
                     /locus_tag="ATCC64974_83100"
                     /product="hypothetical protein"
     gene            14093..15676
                     /locus_tag="ATCC64974_83100"
     CDS             14093..15676
                     /codon_start=1
                     /db_xref="InterPro:IPR013087"
                     /locus_tag="ATCC64974_83100"
                     /note="EggNog:ENOG41; GO_function: GO:0003676 - nucleic
                     acid binding [Evidence IEA]"
                     /product="hypothetical protein"
                     /protein_id="ncbi_ATCC64974_83100-T1"
                     /transl_table=1
                     /translation="MECGEEFIDPSLLCHSTLDGHDLDSRHFNLSNPQPYDLNLQQVPA
                     VLPNAQQRAVPSELFEDATTNNTTAPRGQLPRRRSRYLTRHSGTQAYSVMIPKASSFSP
                     MERWRNSPPEEEGCLIPDIIDALRDNPSQGVQTNLQNPGDDYSAFHGYRRAASITSGES
                     SASSRSTQKSGRSSSSAQNPLAVQGRHGNIRAGKTTRRKTKITSTTAQRRYCCTFCCDR
                     FKSKYDWARHEKSLHVTLEAWHCAPYGTTIMSSNEPSMTRCAFCGLTNPDSDHLEEHAA
                     TACEDESSSRRSFRRKDHLVQHLRLVHNVDSPPQLDSWRIGQSAITSRCGFCSQALMTW
                     KERVDHLAEHFRTGSTMAEWRGDHDFPPDFAALVANALPPYLIGSESQSMIPFSATNCD
                     VEDHLAQIYSRANWDAKDQKEASTITAPSAPSVALPLRALAPGVAPERLSSFTQVLTLH
                     LSRFAQEQMKKGVIPSDEMFQQESRRVLYDSDDSWNQTIADNPEWLATFKDLHFDKEKG
                     VHDSGENFAS"
     mRNA            16398..17486
                     /locus_tag="ATCC64974_83110"
                     /product="hypothetical protein"
     gene            16398..17486
                     /locus_tag="ATCC64974_83110"
     CDS             16398..17486
                     /codon_start=1
                     /db_xref="InterPro:IPR003710"
                     /db_xref="InterPro:IPR008927"
                     /db_xref="InterPro:IPR013328"
                     /db_xref="InterPro:IPR013332"
                     /db_xref="InterPro:IPR013752"
                     /db_xref="InterPro:IPR036291"
                     /db_xref="PFAM:PF02558"
                     /db_xref="PFAM:PF08546"
                     /locus_tag="ATCC64974_83110"
                     /note="GO_function: GO:0016491 - oxidoreductase activity
                     [Evidence IEA]; GO_function: GO:0008677 - 2-dehydropantoate
                     2-reductase activity [Evidence IEA]; GO_process: GO:0055114
                     - oxidation-reduction process [Evidence IEA]; GO_process:
                     GO:0015940 - pantothenate biosynthetic process [Evidence
                     IEA]"
                     /product="hypothetical protein"
                     /protein_id="ncbi_ATCC64974_83110-T1"
                     /transl_table=1
                     /translation="MPLQSHTTRPTIHVLGLGSIGTFTAHGLKDIPNPPAVTLLLHRES
                     LYQEYIRNNRQITLKPVTGDTMHHSDYNLEIYKQGAWHTPADSPADHQIDNLVVTVKAT
                     QTVSALRALRSRLSRASTVLFLQNGCGMIDEVNEHLFPDPATRPNYLAGVISHGVTLAS
                     PFNAIHTGASAISLGLVPRPHSQSSPNTRETGNQLQNRGGSEYMLHNMPVSPRLSAKSY
                     SFSDVFQIQLEKLAVNAFCNPVCALHDSKNSILFEFPKLRRAILTEISSIVLRLPELRG
                     VDGVEQRFAVDRLEETVNGILERTRETTCSMVVDLRNRRETEIHFINGYWVRRGKEVGV
                     STAINEELMDKVLRRSAALRSE"
     mRNA            complement(join(17658..18263,18317..18464,18519..18763,
                     18811..18913,19191..19267,19332..19605,19664..19671))
                     /locus_tag="ATCC64974_83120"
                     /product="hypothetical protein"
     gene            complement(17658..19671)
                     /locus_tag="ATCC64974_83120"
     CDS             complement(join(17658..18263,18317..18464,18519..18763,
                     18811..18913,19191..19267,19332..19605,19664..19671))
                     /NRPS_PKS="Domain: NAD_binding_4 (136-362). E-value:
                     1.2e-13. Score: 42.4. Matches aSDomain:
                     nrpspksdomains_ATCC64974_83120_NAD_binding_4.1"
                     /NRPS_PKS="type: other"
                     /codon_start=1
                     /db_xref="InterPro:IPR001509"
                     /db_xref="InterPro:IPR025568"
                     /db_xref="InterPro:IPR025951"
                     /db_xref="InterPro:IPR036291"
                     /db_xref="PFAM:PF01370"
                     /db_xref="PFAM:PF07993"
                     /db_xref="PFAM:PF13460"
                     /db_xref="PFAM:PF14231"
                     /db_xref="PFAM:PF14232"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score: 97;
                     E-value: 2.4e-29)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ATCC64974_83120"
                     /note="GO_function: GO:0050662 - coenzyme binding [Evidence
                     IEA]; GO_function: GO:0003824 - catalytic activity
                     [Evidence IEA]"
                     /product="hypothetical protein"
                     /protein_id="ncbi_ATCC64974_83120-T1"
                     /sec_met_domain="NAD_binding_4 (E-value: 6.7e-13, bitscore:
                     42.4, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MTSAAEQYRTLVQTKGKVAPATLSNLFDQLPPLKPEQLLGSWNGG
                     FFDTGHSVGPTLQRIGWIGKDFNTLDDVDPVIVLREGRRASWGQWGHATVREMVFRGVL
                     STVMIYDDRPIFDHFRYNIENMSSSGHGQHVLLTGANGFVASHILSILLDRGYTVTATV
                     RSQAKADEVVKAHPDWKGKIEFAIVSDFTSQKPFNTLFEENKIAFDYVIHTASPLKFDI
                     KDIQKEMIEPAVKGTTQILESAHQHGGSALKRFILLGSAVSVLDSFEDMSREGRPYTEK
                     SWNPVTAQQAIERNDTVLGYNVSKTQAERKAWEFMQANNPNFDLTVINPDIITGPMIHP
                     ITGKGSINETNHFAIASFIDGTNSKVEDVRFPFYHFVDVRDVARSHVDALSNPAAGGQR
                     ILLISGLITPQLVVNIIRKHFSELREKVPVGIPDRVLPEGVHPTGWDMRVSLDVLSKGK
                     GSQWQYIGLEESVKDAVQSMLQHNVLPV"
     aSDomain        complement(join(18033..18263,18317..18464,18519..18763,
                     18811..18864))
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ATCC64974_83120_NAD_binding_4.1"
                     /evalue="1.20E-13"
                     /label="ATCC64974_83120_NAD_binding_4.1"
                     /locus_tag="ATCC64974_83120"
                     /score="42.4"
                     /tool="antismash"
                     /translation="LTGANGFVASHILSILLDRGYTVTATVRSQAKADEVVKAHPDWKG
                     KIEFAIVSDFTSQKPFNTLFEENKIAFDYVIHTASPLKFDIKDIQKEMIEPAVKGTTQI
                     LESAHQHGGSALKRFILLGSAVSVLDSFEDMSREGRPYTEKSWNPVTAQQAIERNDTVL
                     GYNVSKTQAERKAWEFMQANNPNFDLTVINPDIITGPMIHPITGKGSINETNHFAIASF
                     IDGTN"
     mRNA            complement(join(20604..21692,21746..21919))
                     /locus_tag="ATCC64974_83130"
                     /product="hypothetical protein"
     gene            complement(20604..21919)
                     /locus_tag="ATCC64974_83130"
     CDS             complement(join(20604..21692,21746..21919))
                     /codon_start=1
                     /db_xref="InterPro:IPR001155"
                     /db_xref="InterPro:IPR013785"
                     /db_xref="PFAM:PF00724"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1217:NADH:flavin oxidoreductase/NADH oxidase (Score:
                     324; E-value: 1.8e-98)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ATCC64974_83130"
                     /note="GO_function: GO:0003824 - catalytic activity
                     [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase
                     activity [Evidence IEA]; GO_function: GO:0010181 - FMN
                     binding [Evidence IEA]; GO_process: GO:0055114 -
                     oxidation-reduction process [Evidence IEA]"
                     /product="hypothetical protein"
                     /protein_id="ncbi_ATCC64974_83130-T1"
                     /transl_table=1
                     /translation="MTQWPDITVKPAEGVSFYTPAQFPPAGTARNPQTSGRPIPNLFQP
                     LTIRGQTFQNRLGLAPMCQYSADDGHMTPWHIAHYGGIAQRGPGMMIIEATGVAPEGRI
                     TPGCVGLWKDSQIEPIRQVIEFAHSQGQKIGVQLGHAGRKASTLPPWLGGGVATNAVGG
                     WVDNVKAPSAISFSNDGITPKAMTREEIDQLKEAWVAATKRALAAGADFIEIHAAHGYL
                     LSSFLSPSSNQRTDEYGGSFENRIRLVLEIAQLSRETVGPHIPVFLRVSATDWVPTDEP
                     GWKGVDTVKLAGALAAQGMVDLIDISSGGIASGQKIKSGPAFQVPFAADVKKAVGDKLL
                     VAAVGMINNGNLAEQILTESNLDVILVGRAFQRDTGLAWHFAKDLDVEIAMAAQIRWGF
                     TSFRNASEYIQPNSMKASIFE"
ORIGIN
        1 cctgctgctc ggtacgggag cccgtctatg tgggagctgc ccctgccaca cagggtcggc
       61 ggaaaatagc gatcatggct caagtgccgc cgtcctgagt ggcaagagga gcttcctcgt
      121 agcaggagtc cggtaccgat gcagacgggc ctttgtacgc cctactggta agcaactagc
      181 ttccagatca cgtcactttg cataggtagt tcacgcaaag tcatggagct caagcgggcc
      241 agccaaggcc caaaatagtc aggacaggtc gcacggactc aacagagcca tcgctgtcca
      301 tgaagacagc tccgataata gcttcaacgg cgctggccat gactttgtcg gataccattc
      361 cggcctgggc tggattgaca atgacaagtt tgtccaggcc caggttacgc ccagcctggg
      421 cgatgtatgt gttgccggcc ttcgttgaga ggatattgtt ggtgaattct gccataaggg
      481 atgagaatgt gattctggtc aaatggaata atatctacct ctgccctttc gggcttcgta
      541 tccgtccagc gccagaacca ttctgagaac ggcatcccca acgagggcaa gttgcttgtg
      601 accatccgtg cgattgatca atccgggcat gtaaacccca gcagcgacta gtgcttccat
      661 cgcacgcttc gggtcattga agatgtaccc gataaggttt tgcagggcct gggccctctc
      721 cgcaagagca gaaaatgaag gcattgtgtc gtcgtacagt tgcttggtgc ggttataacg
      781 agtatcagag cggtcaaagc gagtatataa gaaaagagct ttgtaggaga ggacgggttg
      841 gtaggggatg ggtgaggagg gacaatcaga tgcgaggagg atggcccttt taacccctcc
      901 ccaacccctg gggagggact tatcatgtga tgttgctgca tgtgctgcgc caactatcta
      961 gccttgcatt cgttggtcag cttgcctggc gtatccttga cccttcaata ctaacggatc
     1021 agctatcatc cacaggatac agtacatact tctcttatct ttcggccgct taacctgtca
     1081 acatatttac tctttattta cgctacgaga gtactctagg ccgggtttca tgctcaaaat
     1141 atgagactta ttttgaacgt tgttttaaac gggaaactgt acccccgcaa gttaagtgtc
     1201 tcagcctcgc gggtcacccc atcgatcccg caaaggctga attgaggttg cgcctagcag
     1261 cacccccacc cgaatagtct gtcttggagc ttggattctg gcccaatcaa accctagatc
     1321 aacaacgctg tgaacggctg ttcactaact attggcagct agagccagtg acaaagattt
     1381 acgactgtag cccccagatc gcatcagcta gggattcatt tgttggaaag tatagcgaac
     1441 atatcagctg tcctttgatt ctggctcaac atttggaagc agttggcagg gttgaacttg
     1501 ttgctgctgc tgctatgtga caaggagagc ttatctatat ttatgggtat cgcaaggctt
     1561 tctctacacc catggtgtta tcgcctacta ggcagccttg ctagtcctag caccaaaggg
     1621 tcagtgcacc acaacacctg tggctttcgg ggacagagca ttgttgagta taaccccgca
     1681 atcataccct tgcataaaac ccaccaatag cataagctgc attgatacag agtatactgg
     1741 gcgctttttt gatggagcaa catcatgcgc cacgccagct cctcctagtt catctgctca
     1801 gccacttctg cagggctgcc tgagcgacac attgacatca aagtaaaagc tgagctcgga
     1861 ggctcttaga agcagcgaaa gtaattattg tgaattgata tgaggccagt gactttcatt
     1921 taggcatagg gacgccataa ttgaagcggt aactagcagg agtgagaaag aggagtatat
     1981 ggagaggaaa ctggtcacaa gatttaagaa ataactagaa taagagggaa gtgatatgct
     2041 tttcccaata accactgcgc cacttcccac ccaaaacatg cgcatactga ccaatgaaat
     2101 caactagcgc agatacgaaa atgccagata ccgaacaccc cacttctgac aaaggttgaa
     2161 acaatatgac agtagtccac acattaagta gagggcatgt agaaaccgca atcaccctct
     2221 caaagggctc aattcaaaac ctcattatcc aatcaaagat ggccaccccc ttgatctact
     2281 tcttgactgc atcttgattt gcggatagcg atgaagagat gagcctacgg aaaagcccac
     2341 gttttggttt cggagattgc tcgttgcatt ggagtgtcga agcgtcggaa aaagtactct
     2401 ccgagtcgcc ctttggttgg tttttcgcct catctttagc aagttcgtcg atgaatgtgg
     2461 gcatgtcacg cgtgccagaa gggttcatgc gcatggtcgg agctcgagat gtaggagaca
     2521 tggtgactgg ataatgtggt ttggatgatg actttaagtt caagttcccc ttcgtactag
     2581 ctggagaatg agatcgtagg agatatggaa ggcgtcctga taaagcaatg caggacacaa
     2641 agaataatcg cacgagataa agtagttttt atattctgaa tgtggttgat tcaatttcaa
     2701 gttcctcttt gtacgaggtg gagagtgagg ttgtagtaag agtctgagaa gctggtaatg
     2761 aagcaatgct ggatgaaaag gacagttacc cgagaggaag tggcctatat atactccgta
     2821 tgtggctgat atactaaagt gaggtataga atgcttcaag gcaacaatat tggccttcct
     2881 aacgcagtga cattcccgta gacaagcatg tgatgggtag acagctaaaa tctcacgggc
     2941 ttggcggaaa cacaagtgcc catttttccg ttctagaatg ccatgacgct gagagctgtg
     3001 atgttcagcc tcacggaaaa aatatcttag caacatcttg ttcatgcctt cggcgcaggt
     3061 attcagagta tgggaagagc gggattcaga ctttgccgta tatcgagaga ggacccccat
     3121 attatagcta agagctatta accacatcat atctaggccc taacatctgc gtatatctca
     3181 cataaagcag catgaatatc tcgcatcgaa gtctctaccc caaagctctg gagcttggcc
     3241 agtggtctgg acacctgggt atttgtgaat tgaatgacga catagacact ttagccgaca
     3301 gactatatcc tcgacgtgag tcagggggcc cattgttaat ttaatctaat gcgtgatgta
     3361 gtctactagt gtctagacca cagctagtaa gcgatatcat tggctatagc tgaccgcagg
     3421 cttcgaatgc cttcagaacg ccgacaacag tacacaacaa ccgcacattg caagtaaggt
     3481 gtattttaca caatatatgg actatgtgaa agtactttta ttcaatgcct taaatgtttg
     3541 aacttctaca tgaaattata tttcagtatt cgaatcaaac gacaagtaag gtcatgccta
     3601 cgagacgcag gtaacaatgg gttagatgca ttgcgtcata ccttagttgc ataaagtgaa
     3661 caagctgaaa caatcataac gtgactctca gagcagccgt tcaacgccaa aatctatcct
     3721 atgcatgatt tggcagccta agtggctgtg gaagaataat gcacacagcg gctaatcagc
     3781 atccaagatt tactaaaacg gctttagctc gcgctacctt atctttccaa tcaacaacca
     3841 ctcatattgt ggcattttag acggtatggc caattggaca catcggattt cttctcacag
     3901 tcacatggcc aacgacgtgg caactatcta cttaccgtga ctcacaacag acgtgtttgc
     3961 ctgattgacg tgagtaagct gctgggagct agattgaggt gtccaggggc attccagact
     4021 ttgcctgcat ttgttttcga ccggacaatc ggacctcttc taactcagca ctccctgtac
     4081 gcagtgcacc gccaaattaa tagctctttc agagtcgaaa gtaaaaaagg ggttattgcc
     4141 atgattcaca gcgaaaaata aatccagtct ctcggctact ttgaccttaa ttcatccgtt
     4201 ctcattgatc gaacaacatt ttttttgcgt actatttctg gagaacggaa cttactctgg
     4261 tatgttcacc caccaataga agggaatacg acatgaactt ggcattcgag cttagcactc
     4321 ggagatatcc gagctgttcg gtgttaaagg ttccggtggc gcaatagttt tcagtctgga
     4381 ccggtttctt ggatgctagt aaatgtcccc gccaatcaga cccaccgggt acctgatccc
     4441 aatatctaaa aggtaaaaag tgccgatcag attcgtgagt tccttgatgg ccatgcgcta
     4501 atgtcgattt aatctccgcg atacgagtgg caaagtggtg ttatgtggtt gagattttca
     4561 actagcgtgg atcttgagtg gggaggtact gactcgagat gtagagaggg aataggtctg
     4621 cattctacgc agtctgctga aggcatgttg acttatctct acttaggaca attaaaaaat
     4681 gcatcgagca gcggatgtaa tattataagc ggtaaagttt gactagtgtt tctctaaggt
     4741 ataatgacaa ccttctacat ttgctataac gttacccctg tacgcccaca acacgaccgc
     4801 aatttccgtt ggacatctgc atggtagtcg aagcgtcatg aacagacgcc ttggcgtaaa
     4861 cggaagactg cgagcaggtt gtggtgtgaa tgagatagca gtaactgatg gaggaagtta
     4921 ccgcgttgta gtaggacatg gcgcaggtag agctctccat gcagctgaca cagcaatcat
     4981 atgcagagct ggtgtcgcca acagtcaagc tttcaccggg aacgttggtg aaggtgacca
     5041 ggtacatgta ttggcccgca aaagagccaa atccagagga gagagggtcg ccagcaatat
     5101 tgctagaccc gcacgcctcg tagaaggtgg tggtagccac ggcggccacg gcgctggtag
     5161 ttgacgtcac ggtggttgtt tcggcagccg cggttgtggt ttcagtgatg gtggacgtgg
     5221 tactgtagct cagcgtggtt gagacatcgg aaggggccac gactgaagta ctggtgatag
     5281 tgtttgtcac agtcacggtg gatgtaggag tgactgcggt agcagtcgcg ggagattggg
     5341 tcactgtgga gacggttgtg gtcttgacaa gaatcttctg gtggcactcg acctcttgag
     5401 gatattgata gtcgtccagc caggaggaac aatcgtcctg ctcgatcaag gaccgcttgg
     5461 cagcagtagc tgtaggcagt gtttccacaa tgggagaaaa acctgaagag ctggcaattg
     5521 tggacgtgct cgtgctcgtg gtggagatgg tgacagatac aatggcagtg acagcagcag
     5581 gagtgatagt caccgttgca gtgtcatact cagttgaggt tgtcgagaaa gtatcagtga
     5641 ccgtgtcagc tgtggaaatg gccgtggtcg tctcatagtc ggtgacggtg acagtcgagg
     5701 cgtcaggggt cacagtgaca gtgtcttgtg tcgtcgaaaa gacaacaacc ggtgtcgggt
     5761 catggatggt gcgcgtaatg gtagtggtag gaacaagtgc cactgagttt gttcccagct
     5821 gcgtgcggca ggacaccgaa ggcacatagg cctgactgct ggccacaggc gagctggccg
     5881 cgggggtgat ggctgcgacc cgaccgagca gaaagcccgc ggcgacaatg aagccctgga
     5941 ttgacattct cacaggttgg caaaatatga agtaaatatg tatggcaatt actcaaaacc
     6001 ctcggtaggt tcggagtgtc ctcgcaataa gtactccgtc cctgaattct ggtgggattc
     6061 ggtgtcggct attttcgccg tcattgatag acccgcgacc cagtgggcgt caatagtcca
     6121 gctgaatacg aaggctgaga caggaaccag aaaatagctc cgtcgcgtgt gcattccttc
     6181 tttgtattct ctttgccgaa tctccgaccg agaggaaatc cttgagtgat ctatatacag
     6241 tgacccgcct cttgcaagag agaatcaggg ctcggtttcc cacaccctct tttgacagtc
     6301 ctttctcatt ggaattcaac cacaagtcat tcatttatat ttcatgctac ctgattactc
     6361 ttgatcaatc aattctactt tccttaataa tcttcatttg atacggttga gctgagtcga
     6421 tcgctgtcag aatgggtcac ctgctgatgc gaggatggat cctcgcctcg ttattgatgc
     6481 aaaccagcat cgccatgacg gtcgttgttg agccagcagc tgcgacttct accactactt
     6541 cctctgctat cgcacatacg catcatcact ggtcctatag ctcaaggtcc ttgcccagtc
     6601 gcaggccatg cacacccagt ttttcgtcgt ctgttccttc ttcgaaggca gcaactccta
     6661 ctccatcaat catcgtggta ccctcgtcga gtgcagtccc ctcaccctct acctcgcctg
     6721 taagggaatc gccaactccc agttcaaggc cggtacccag tcgttcagca gctccccgcc
     6781 cgcattggac ctatgtatcc cggcctttac ctcagcgaag ccagtgttcg gcttcgtcca
     6841 gagcaattcc gagctcttca ctccctgtcc ccagactatc tggaatcaca tccagcgcag
     6901 ttcccgcgct aacccctgtt ggggccgcat ttcctcagtc gaacattttc acatcctcgt
     6961 cagctgcaac attcgccgag tcttccacac tgcagttaac tacgtcggcg gtcctctcta
     7021 ctcgtacggc cacaattact gcatgcccat ctgcagtccc agattgtcct ccacgctcga
     7081 gaacaaccct tgtcaccaca gagaccattg tggtgtccac cacagtatgc ccagttaccg
     7141 aggctgctcg tgcgactcgg acggattctg cctcgccgac agcaaccgac actgctgtca
     7201 acaatggtca tggcagcggt ggagcggagc ttacaacttc cacggttttc agcactcgca
     7261 ctgctaccat aactgcgtgc ccttcctcgg taacaaattg cccgctcagg tcgaaaacga
     7321 cctatgtgac caccgagacc ttggtagtct caaccactgt ttgccccgta gccgacatca
     7381 ctggtagcag cggcgctgta attgctaccc agtctgcatc tcatccttcg gctagcgtgg
     7441 ctgttggtga caactggagc agcatgggtg gatttgacat tactacttct acgatcttga
     7501 gcacccgtgt gatcactgtt actgcatgtc cctcttccgt gaccaactgt cccatgaggt
     7561 ccaagacgac ttatgcaagc actgagacac tggttgtcgc gacgactgtg tacccagtcc
     7621 cgaaggtctc taataccaaa gcaaagactc ctcttccatc tgtcacaaga gcatcggaag
     7681 agggaccatc actcaccacc tccaccatcc tgagcacccg cattgccaca gttgccagct
     7741 gcactgggga tgactgtcgc agttcatcgt ctgactctta tgtcacgact gagaccctcg
     7801 ttgtaggaac gaccgtttac acagtatatc cagaatatgt atccgtccca accgaaggtg
     7861 ttgatgctat ggctgctcct acgaccgctg ccacgctcct ccagactgcc aactcagcgg
     7921 gtagctcccc caaggttgtt tcatctggat cgcagcccac atctgcaagt gagactagca
     7981 ctcagggtac aggctcaagt gcaggctcaa gtgcggagtc aagtgaagga tcggatgccg
     8041 gctctgctgc agactccagc gcagtgtccg gtgcgggctc aggtgcagcc gcagacacaa
     8101 cctacaccac cacgattatc gtcgaatcat gctccaatga cggaacctgc accgagtatg
     8161 gcagtaccat cacaatggcc cagacctcca atcttgctca gcccactgtg cctccctccc
     8221 cgtattcgta cacctcgtac ttgggctcag gattgggttg gaaccacagt actcctgtct
     8281 cttcagcaca tgtctggccc cagagcagtc accaagctgg catgagcacg gctatggtta
     8341 ctagcacaag aagcgcaagt gccgttaatg cattgtacac tgggtctgct tctgcaggtt
     8401 cccagtggtc gatgctgcag gtggtcggaa tggcggtagc aattctgacg gctgttcttg
     8461 tctagttacg tgtggggtta tagtataact ttgaatgttg tatgtcgtct gattacaatg
     8521 tatactattg tgctatgttc aattgaaggt cctccaggct tatttgactt ttgcggtggg
     8581 agcatggcct aatgggtatg gccattaatt attccctagt aaacttgagc ccgcaagtat
     8641 tgatcaacgg gcagccacat gggccaggac acaactactg tgatcatcct taattttctt
     8701 tgcagataag actttttata cgtacataca agcaactaac aagcccaata taccatattt
     8761 gtgtggatta gtcagaatca aagcaaacca gatcagcata gccagttggg ttcctcttgc
     8821 caatgttgat cggaatggct gtggcactat ccccatacaa actggtagca aggatggagt
     8881 gtcggagttt cttgcccccg gggccgattg actcgattta gcaagccctc actgtgccaa
     8941 ctctgtagta cctaatagca gcgcctgtgt tgcaccagaa cggctaagaa ggttatagtg
     9001 ggatactcat agggcccaac ttatctgttg tagaaaaata tcatcttaca tgcggcaggt
     9061 actctcgtaa tgctgtacat taaagtaatt gatactgagc attccttgcc attactataa
     9121 tttaattaaa aggtccttgg atatgtgcgc cgacggattg gaaatctggc gacatactgc
     9181 tggccatggg tacggacggc taacatgttt gctgcaattt atgatatgga gtttgccagc
     9241 gccgtatgac gagacctgca tcgaagcctc aattatagga ctatcctgtc acctgcagtt
     9301 tgccacaaaa gtcaatgaga tttcactggc gccaatgtca agccaggaca ttagtttgga
     9361 atctgcggca tattctgcgt agtccctcgg aaaatccatg tgttcgtacc agaaattccc
     9421 tgaacactac atagggagtg caaatattcc acaagacaga tgcgatgatt caacgatgat
     9481 agtaatggtt ctttattcga ttcttgatag cgaattggct ttttgtggat ttagattgcg
     9541 cgttcatcta cccatgttca gattgtagcg ccaaatatat ttacccaggt cagtaaatgc
     9601 gtatgcagca ttaatagcta tgggccaaat tgttgggggc gcatattaag gtggggcagt
     9661 agtcaaaagt tatatcttca ctgactgact caggacatgt aatgcagccg ccaaagcgca
     9721 gcaactttca tgataagttg aagtgaccag ccaattggac gcctttcgca tacttaagcc
     9781 tgtacggagt tgcagatttg tttgttaaag catatattat gcgacgaaga attccttgaa
     9841 ttcttagcga gctaacagcc aaggtacgct cgagagataa catcattcat atatctgccc
     9901 tgtacgtcct gcagctattc cggttacaag atccaggtct tcatcatcta gtcgaatgac
     9961 ttatatggag cctttctcat ttcttaacac ggctatcatc atggagcccc tccagcatca
    10021 tcttccgcaa acttcgctgg cttttctcgc cttactggcc gtcccgataa cggcgctggt
    10081 atgggatcgc atattgaacc cacttccgac aacaaagcgg gcttggcttg ttggcaagaa
    10141 gcaaccatct cggatcactt cactggagtg cccctacagc tacatccgcc aaatctacgg
    10201 taaacaccac tgggccccat ttgtcgacaa gctggcgccc agcctcaagt tggaggaccc
    10261 gccgaagtac cagctggtcc ttgagattat ggacggcatc catctctgtt tgatactggt
    10321 tgatgatgta agtgcagcac cccactgaac atatggagta gagagctaat aaccccataa
    10381 gatctcggac gggagtaact ttcgcaaggg acatcccgcc gcgcacaaga tatacggccc
    10441 ttcagagact gcgaaccgtg cctactatcg cgtgacacaa cttttaaacc ggaccgtcca
    10501 cgaatttcct cgtcttgcgc cctttctgat gcagtgcctg gaggagatcc tggaaggcca
    10561 agatatgtcc cttgtatggc gaagggatgg tcttgccagc tttccagtgg gtccaaagga
    10621 acgggatgca gcatatcggc aaatggcgtc gctgaaaacg ggcgcattgt ttcgtttgct
    10681 cggtcagctg gtactagaga ataagtccat ggatgctacc atgactacgg tggcgtatgt
    10741 gcaaagacat ccgagcattg gggattatgg ctgattgacg tctacacagg tggtgctcac
    10801 agctgcagaa tgactgcaag aacgtttatt cgaccgatta tgcgaaagcc aaaggtgcac
    10861 tggcagaaga cctgcgcaac ggcgagcttt ccttccccat agtggtggca ttggatgctc
    10921 ccgagggtca tctgatagcg cgcgccttgg aatacggctc accccataat atccgtaatg
    10981 ctctacgagt aattcaaaga gaagatgtgc gtagcgcctg cttgtgggat ttgaagaaat
    11041 caagtgcctc cgtacaggat tggctggaag tttggggtcg gaaggaaaaa atggatgtca
    11101 agagtgtgaa gccgtaagcg ggaatgtaga taggcgaata ctttgcttag tgatggaaac
    11161 tgttgcaata ctccttattt aagagaattt aatctctcta tcctatagga ttctcattac
    11221 tgactgcgat aagctttgca ctgaggcaca gggataaggt ctgtacgaca gtgtaagatg
    11281 gtaccgtata actacgccgc atcttgcatt agcagcgctt tcacgatagg tattctgcta
    11341 ttttgccgat aagctggcca caatgaccat tctcgagtta taaggagaat tggctaggaa
    11401 gctgaacgga gaaactttat cgagccaatc tctatgactc gggcgaccta agcgacctgg
    11461 tcttgtttga aaccaacgca tagcatcccg gatgtagaag agtctttggc aaacacaagg
    11521 ttaacacgcg gacacggagc aactcaccag taccagtagc aaggctattt gatgaatgtt
    11581 ctctgagatt gcttgctgac tagacgtgct tccaagagct tgtcgacgtc actaatttgc
    11641 tgatgacaag tgcccagtaa agctacgcca agtgacagca aaacatgtag cagaagccaa
    11701 aacagttcta taaggtgaga ctaatagaag gcgtactctt atatacctga gagatatcaa
    11761 tgcttctccc tcgaaagcac acgtttagtt ccttcttagt agccttcttt tccatcaacc
    11821 tcgatccgta cagtgctctt gacctacaag agacgaaaaa atgctcggat ttccaatgtt
    11881 cagcccagag acacctgacg cctggaagat gaataccccc tactttcctt ttgtttcctc
    11941 gggtgtcttc tctgcatcga taccatcatc acccaccaat atagaagctg cgagtacttc
    12001 acagtctgaa acaagctttc tggacaagga aaaggtctga agcttcctgt ccatggtcag
    12061 tcttcgtctg atgtgagata acagattgtt cgaggaccac ttgactacct tcttaaatca
    12121 cctgggaagg atattcgtcg caaattcatc cacgcattca acgagtggct gcgcatccca
    12181 gaagagaaat tgaatatcat tacagagatt gttggattgc tccacacagc ttccctactg
    12241 tatattcctt ttcatttccc acatgatcga agttcttaat gtctcggaaa ctagctgatc
    12301 ttttgaagaa tcgatgacat tcaggacaat tccaaacttc gacgcggcct cccagtggcc
    12361 cacagcatct tcggcattgc ccagaccatc aactctgcta attatgcgta ctttttggcg
    12421 caggagcggc tccgcgaact gaatcatccc gaagcgtacg aaatatacac cgaagaactg
    12481 ctccgtctgc accgcggtca aggtatggac ttgtactggc gggattctct gacctgtccc
    12541 acagaggagg actatatcga gatgatcgca aataagacgg gtggcctttt ccgactggct
    12601 atcaagctta tgcagttgga aactgaaaca aaaaggcaag tgttacatat ctgtcacaat
    12661 actgtaaagc tccttgtcac acagcagact gactctatgc agcgatgtca tcgagctagc
    12721 agatttgttg ggggtgatct ttcagattcg agatgattac caaaatttgc agagcggact
    12781 atacacgaag aacaagggat tctgtgagga tttgacggag ggcaaatttt ccttcctgat
    12841 catccacagt atccacagta acccgaataa tcatcatctg ctgaatatat tgcggcaacg
    12901 gagcgaagac gattcggtga agaagtatgc tgtggagtat atcgactcga cagggagttt
    12961 cgaatattgt cgggaacggc tcgcttcctt gttggaagag gcggatcata tggtcaaaga
    13021 gctagagagt caggttggac attcgaaggg gatctacgaa atattgagct ttttgtcgta
    13081 attgctagat gtggggggcc tgtgcttcat tgctaggtat cttgctgaaa caaatagtgt
    13141 tgttgtcttg tcgtcacttg cgtctagaaa tgaagtgcgt ttgatactca cattttttgt
    13201 ttcaaaaaat cagagatatt atacggatag atattacagt ctttcagtat gaacaagata
    13261 tcataaactg gcatggtgag atttcaaagc ccgttgaact tcacccaccc gtgacttgtg
    13321 accgtctttc ggttacactg gcttacatgt attagctcac agtatggggt cagaggtgca
    13381 ggaggaaatg gaatgttggg cgacaaggag aagctgaata ctacacatgc atttcaagtt
    13441 tgatgggctg tgcttatcat tattgtccca aggctggttg gctcccagga gaatttagcc
    13501 gacagatgca cgctgagtct gtctgcaggt gccgcgttga tacccagtct gcttggtctt
    13561 cagcgagaac aacaatgtca atgggtctta tggagtgtat tgaagctcca atatttgatt
    13621 cgtaaggcat tcattcatgt atcatcacat gtcgatgagg aatcaatcac ggttcaatgg
    13681 ccaggataca ttgccgccgc tactgtctac taggacaatg tagaggacaa ttccccctta
    13741 attcaataga tggtgtattt tgaatcgatt tgcggagtgc tacccaatct ctgtcacgtc
    13801 ggcagtgacc attcaaggct caaattgtag ccacagggcc tcaaccatga actggatagt
    13861 ttcatcggga tttgctgaga ggccgaccgc caccctgttg gcctgaggca gaatagatta
    13921 cataatgtct caagcaccgg cacccaaaat aggatgaaga ggaatgaagt tactcttgct
    13981 tcctttccat gatgtctatt gggtaggaga atgcgataat ggttagcccg cagaccctta
    14041 ttatccgaaa ctctgaagag aaactttgct tagaatagct gcagctgcca gcatggaatg
    14101 tggcgaagag ttcatcgatc catctctgct gtgccactcg acgctcgacg ggcatgattt
    14161 ggactccagg cattttaatc tttccaatcc gcagccttat gatctgaatc tccagcaagt
    14221 accagcggtc ctgcccaacg cccagcaacg ggctgtgcca agcgagctat ttgaggatgc
    14281 gaccaccaac aacactactg ccccgcgggg ccaacttcca cggcgtagaa gtcggtactt
    14341 aacgaggcat tcggggacac aagcatactc tgtgatgata ccaaaagcaa gcagcttcag
    14401 tcctatggag cgctggcgga attcgccccc tgaggaagaa ggttgcctaa tccccgatat
    14461 catcgatgct ctcagagaca acccaagcca aggggtccaa accaacttgc aaaaccccgg
    14521 cgacgactac agtgcgttcc atgggtatcg gagagctgct tcaattacta gcggggagtc
    14581 tagtgcatcc tcgcgaagca cccagaaatc cgggcgttca agctcatcgg cccagaatcc
    14641 attggcggta caggggcgtc acggcaacat cagggcgggc aagactacga gacgaaagac
    14701 gaagattact tcgaccactg ctcagcgtcg atactgctgc acattctgct gcgaccggtt
    14761 caaaagcaag tatgactggg cacgacatga gaaatcgctc cacgtcacct tggaagcatg
    14821 gcactgcgcg ccttatggca ctaccattat gtcctctaat gaaccttcta tgactagatg
    14881 tgccttctgt gggcttacta accccgactc cgaccatctg gaggaacacg ccgccacagc
    14941 ttgcgaggac gagtccagca gtcgacgttc cttccgccgt aaagatcact tagtgcagca
    15001 tctacggctc gtacacaatg tcgactcccc gccacaactc gacagttgga ggatcggaca
    15061 gtccgccatc acctcgcggt gcggcttctg cagtcaagcg ctgatgacct ggaaagagcg
    15121 tgtggaccat ctagccgaac actttcggac aggctcgaca atggcagagt ggcgcggcga
    15181 ccatgacttc ccgcctgatt tcgccgccct agtagccaat gcattgcccc cttacctcat
    15241 cggctcagaa tctcagagca tgattccatt ttcagcgaca aattgcgatg tggaagatca
    15301 tttggcgcag atttactccc gagctaattg ggacgcgaaa gaccagaaag aggccagcac
    15361 tattacagcc ccttcggctc caagtgtagc cttgcccttg cgggctcttg caccgggtgt
    15421 tgcccccgag cggctcagct cgttcaccca agtgctaacg ctgcatctca gccggtttgc
    15481 acaggaacag atgaaaaagg gcgtgattcc gagtgacgag atgttccagc aggaatccag
    15541 acgagtactg tatgactcag atgattcatg gaaccagacg attgcagata atccggagtg
    15601 gctggctact tttaaggatc tgcatttcga taaagagaag ggtgttcatg attctggcga
    15661 aaactttgcc tcatgaaccg aatgaataca acgtgtactt agggtcccat gtctcccttt
    15721 ctttccttca ctctcgggtg atgtacttat acccccagcg tagtataccc tgagcagtct
    15781 gtgcttccta atctcagggc tgctgatgct gctgccaacc ggagatgcaa cagccgatct
    15841 gtatctccgg gagcgatcgt cactgtggtc aaaatatggg atgtaggtac cggatgagcg
    15901 ggttagagag cgtttcggct atcctttgaa cgaagagatg gacctatggt gagatagtat
    15961 ggcgctatga gagttggtga gaccggaaat ttgtgtaagc cgaaggattg tcttcaggat
    16021 gtctcgaatg tgtggtgaag gggagagcca aaggctagcg gggacacgtt cggcgggttt
    16081 gggggtggga gcgttggaac aaaatcgtgt aaactgtaaa ctttgctggt tagccatgtt
    16141 ctcatacatt gtatgtaaag taatcattca atgttcggat aatagctagg tgtgggtgtg
    16201 atgaaggtga ggattagact ggaaaagctg gaagaaactt catcttgcca cagggcgtag
    16261 ggcgtaaggc gtacatgaag cgacacttcg ataaaaccga tgattctcaa tcacagcaag
    16321 gtgttcaaca cagacagagc tcgataacaa tgcaaaaacc aatatacaaa cagtttgcac
    16381 ggtgctactc tacaagcatg ccactgcaat cccataccac tcgtccgacg atccacgtcc
    16441 tcggtctcgg cagcattggc acattcacgg ctcacggcct aaaagacatc ccgaaccctc
    16501 cagctgtcac cttactcctc catcgagaat cactctacca agaatacata cggaataatc
    16561 gccagataac tctaaaacca gtgaccggtg acacgatgca ccacagcgac tacaacctcg
    16621 agatctacaa acaaggcgcc tggcataccc cggccgactc tccagcagac caccagatcg
    16681 acaatctagt tgtaacagtt aaagcaacgc aaacggtatc tgccctccgt gccctcagat
    16741 cccgactctc tcgagcctcg actgttctct tcctacaaaa tggatgtggt atgatcgacg
    16801 aggtcaacga acacctgttc ccagaccccg caaccagacc aaactacctt gccggagtca
    16861 tttcgcacgg agtaacgctt gcgtctccct ttaatgcgat acacactggc gcatccgcaa
    16921 tatctttggg attggttcct cgcccgcatt cacagtcctc cccaaacacc cgagagaccg
    16981 gtaaccagct acaaaacaga ggcggatccg aatacatgct gcacaacatg ccagtctccc
    17041 ccagactatc cgccaaatcg tattcttttt cggatgtgtt ccagatccag ctggaaaagt
    17101 tagctgtgaa cgcattttgt aacccagtct gtgcgctcca cgactcgaag aacagcattc
    17161 ttttcgaatt tcccaaacta cgtcgggcga tcctcacaga gatatcaagt attgtgctgc
    17221 gcttgccaga gttaagaggt gtggatggag tagagcaacg atttgcggtt gacaggctag
    17281 aagaaacggt gaatggtatc ttggagcgga cgagagagac cacttgctcg atggttgttg
    17341 atttgcggaa taggcgtgag acggagattc acttcatcaa tgggtactgg gttcgacgag
    17401 ggaaggaggt tggtgtgtct actgcaatta atgaggagtt gatggataag gtgttgagga
    17461 ggagtgctgc tttgcgctct gagtaacttg ggagccatgt ttttcggatg ctcagatgtg
    17521 aatacacacc aatgatggct gaaatgtgga tataagaagc ccgtgtaggg gattttgagt
    17581 ccaatgtgtc tactgagaag tctacaattc actaatgtct ctgtcaaatt gacatgtaag
    17641 tacaaaattg cgttacatta tacaggcaac acgttgtgct gaagcataga ctgcactgca
    17701 tccttcacac tctcctccaa gccaatatac tgccactgac tgccctttcc cttggagagc
    17761 acgtctaagc taactcgcat atcccacccg gtaggatgca ccccctcagg cagtacccta
    17821 tccggtatac cgaccggaac cttttcgcgt agttctgaaa aatgctttcg gatgatattg
    17881 actactagct gcggtgtaat aagccccgag atcagcagga tacgctgccc tccggcagcg
    17941 ggattagaaa gtgcatccac atggctcctt gccacgtcgc gcacgtcgac aaagtgatag
    18001 aatggaaacc gtacgtcctc aaccttggaa ttagtcccgt cgatgaagct cgcaatggca
    18061 aaatgattag tttcattgat cgaccccttc ccggtgattg gatggatcat gggtccagtg
    18121 ataatatcgg gattaataac tgtgaggtca aagttgggat tatttgcctg cataaattcc
    18181 caggctttgc gctcggcttg ggtcttagaa acgttatagc ccagcactgt gtcattacgc
    18241 tcgattgcct gttgcgcagt tacctagact tccattagcg tgtgtcttgc cggtttcagg
    18301 ttcttgaacg acgaactgga ttccaacttt tctcggtgta tgggcgtcct tctcgactca
    18361 tgtcttcgaa ggaatccagg actgagaccg cgctgcctaa aaggatgaag cgtttgagcg
    18421 cgcttccacc gtgttggtga gcgctttcca gaatttgagt cgtgctggag gtgtatttta
    18481 gtggttataa cacggttgcg aagacactat tggcttaccc cttgacagcc ggttcaatca
    18541 tttctttctg gatatcctta atgtcaaact tcaatgggga tgccgtatga atgacataat
    18601 cgaaggcaat tttgttctct tcgaacaagg tgttaaacgg tttttgggag gtgaaatccg
    18661 acacgatcgc aaattcaatc ttccctttcc aatcagggtg agccttaacc acttcgtccg
    18721 cttttgcttg agatcgcact gtcgcggtca ccgtgtagcc acgctgagcc tgtcagatcc
    18781 tgcacgtctc gttagagagt agtcacctac atccagcaag atagagagga tatgcgatgc
    18841 gacaaaaccg tttgccccgg ttaaaagaac atgctggccg tgtcctgacg atgacatgtt
    18901 ctcaatgttg taactataga tggtcgtgtc aaaaggcctc tgggcctgtc aatcaagaaa
    18961 tcctcttgga gactgcaaag tccgatttaa tttcttgaga gccgatgtca cgccacttaa
    19021 aggttacgag atactccatg taagaggtac gtgtacgcaa acgtcatatc tgaacgggat
    19081 ctgaacctta acctcgattt ataatctatc gcgtcaagta aaagtaaaag tcccctccct
    19141 caacagcctt tccctccatc acccccgcca ccaagttgtc atccacatac cggaaatggt
    19201 caaaaattgg tctgtcgtca tagatcatta cagttgacag cacaccccga aacaccattt
    19261 cccggaccta atacgcaaca ttagctgaat ttggacttcc atgcgatgac aggcataatg
    19321 tccttgcata ccgttgcgtg cccccactgc ccccagctag ctctccttcc ttcgcgaagg
    19381 acaataacgg ggtcgacatc atccaaggtg ttaaagtcct tgccaatcca gccgatgcgt
    19441 tgaagcgttg gaccaacaga gtgtcccgtg tcgaaaaacc cgccgttcca gctgcccaag
    19501 agttgttcgg gctttagagg aggcagttgg tcaaagagat tgctgagcgt tgcgggagca
    19561 accttcccct tggtttgcac gagagtgcgg tattgctctg ccgcacttga tggtagctga
    19621 gtcaatattt tgtctccctc ttgttcggct gagtgttcct tacgatgtca tttttccaag
    19681 tgtgatgtct tagtggatgg tgtgacagtg tgcagtttcg acgccgatac actctactcg
    19741 tttcagcgca ttagcaagat atttatattc acgtctagac acgaaggctg caattattaa
    19801 tggtagagca aaatatacgg gaattggatg aacaaagttg gtgtcgaata gtaattacga
    19861 actagtctcg ctgcagaagc ttcttgatct catgtcattc attcatcttg catgggactg
    19921 ttttcagagt cagccttcga cccacggaca gcccgcccat tttccgcaga actgcgccct
    19981 acggtggatc gctccacatc tcgggatctt cggagagttc tgggctttgc tcatcggagg
    20041 ctttttgaat gttactccgt actacgatta ctggatgatc gtgaggtttc tctattgctt
    20101 acttactaat tgatgtttca tacagcaacg gccctggaag tgtgccttgt cgaagagaac
    20161 tggcttcatg atgttgccgc cttgccaccg tcctgatcgc atgtaaacgt gtgatgatgg
    20221 caaatccggt gcagcaacag tggaaaccaa tgttgattat caggatacat ggtttttggg
    20281 acatgtctct gtgactactc taaggattag ccatgacata tgatcggttt tggtctgttt
    20341 agtgacgctt tgacagcaac ttatgcatgt tgaagcgcag tactttatta ttttatacat
    20401 gtgatactac tggtagcttc attccaggta actgcagcct ggagtgtaaa cgagcataat
    20461 cttgatcctg tcatttgatg ctagcaatcc tgtaaaccga gttgaagcca gtatatgtaa
    20521 aagtgctaat atgtatcgag gaaaatgaag gcctcttgtc tatagtctat caatttatcc
    20581 gaaaatataa cgatcgcaac tgtctattca aaaatggaag ccttcatcga gttaggctgg
    20641 atgtactccg aagcatttcg gaaactggtg aacccccaac ggatctgcgc cgccatagca
    20701 atctcaacat ccagatcctt cgcaaagtgc cacgcaagtc ctgtatcccg ctggaaagca
    20761 cgcccaacca atataacatc caagttgctt tctgtcagga tctgctcggc caggttgcca
    20821 ttgttgatca tgcccacagc agcgacgagc aacttgtcgc ccacagcctt cttcacatca
    20881 gctgcaaatg gaacctggaa cgcaggaccc gatttgatct tttgcccaga ggcgatgcca
    20941 ccactgctga tgtcgatcaa atccaccatg ccttgtgcag cgagtgctcc cgccaatttc
    21001 actgtgtcca cgcccttcca gcctggctcg tcggtgggaa cccagtcggt agcggaaaca
    21061 cggaggaaca cagggatgtg ggggcccact gtctcgcggc taagttgagc gatttcgagc
    21121 actaatcgaa tgcggttctc aaagctcccg ccgtactcat cagtacgttg gttcgaagac
    21181 gggctcaaga aggaagaaag aagataaccg tgggcagcgt ggatctcgat aaaatcagca
    21241 ccagcagcca aggcgcgctt tgttgcggcc acccacgcct ccttcagctg gtcgatctcc
    21301 tccctcgtca tagccttcgg cgtaatgcca tcgttggaaa aggagatggc gctgggagcc
    21361 ttgacattgt ccacccagcc gcccactgcg ttggtcgcga caccaccacc caaccaagga
    21421 ggaagagtcg aagccttgcg tccagcatgg cccagctgaa ctccgatctt ctgtccttga
    21481 ctgtgggcga actcgatgac ttgtctgatg ggttcaattt gggagtcctt ccagagacca
    21541 acgcagccag gagtgatgcg cccctcaggc gcaacgccag tggcttcaat gatcatcatg
    21601 ccggggccgc gctgggcgat accaccatag tgggcgatat gccatggggt catatgtcca
    21661 tcatcggcac tatattggca cattggggcc agctgtcgga gctgttagta tcaaggatta
    21721 cacttggatg gctgaaagta ctcacgccca ggcgattctg gaaagtctgg cccctgatcg
    21781 tcaaaggctg gaagaggtta gggataggcc gtccgctcgt ttgagggttg cgtgctgtgc
    21841 cggccggagg gaattgcgct ggggtgtaga aggacactcc ttcggcaggc ttgacagtga
    21901 tatcgggcca ctgagtcatg atttcactcg ttggaacagg atatgagatt ctattgtata
    21961 gatgatgcaa tgtgatggtc tccccagttt gctctgctac atgacgccca tcttataacc
    22021 ttgacaagct catactcgaa ctttccacat cccctcgaac tgtatacatg atttgtaagt
    22081 tcggaagcaa ttgaagatta ctaatgcggc gcgaaaagtt caagcctagc tcatgttggg
    22141 cgcgaagggc gcaccaaatc ccggcttctc ggttccacag aagcattaaa cttaatcggt
    22201 cgggatccaa gcttgcccca gctcgggctt tgccgctgaa gagttgtggg ccgttataaa
    22261 tcttctcttg ccgttatgcg cagttctgcg catttcttgc gatatacgcg gggctcacca
    22321 gtatacccag ctggactggt caagcaaagt acggtagctt caatggtgga actgggaata
    22381 acaaacgtag ccaccatagt ttaatcccgc gccctgttga gtgaaaatgt aatatctggg
    22441 acgatgagat cacttcacag tcagagcctc tccagacccc gcttgcggta cgtcatagag
    22501 aaggtgcgca atgaagcttc aatatgtcca gcgcatgtgt agaaagtata tagtctgttg
    22561 gagcacatat ctcttcaccg ccggctactg gacacgatat atagttcttg gtctagccgt
    22621 tagcacgtcg acatagttca cgaaagttgt cgcaaaatac ctttgtcgcc ttcacgacct
    22681 acttactaca tcgtatatcc aaacactatc aatatctcaa catgccctca gcaattgtta
    22741 ctggagctac cggtaacata ccccatttca ttaaccacag ggaaatacta actgaggcgg
    22801 ttcaggcatc accggtagcg cgattgtcca tcatctttgc aaagactcca gctacgacaa
    22861 gatcctctcc ctttccagaa aaaatcccgg ctacgacagt cccaagattc agcatgccac
    22921 tctagaccta caaagctcag ttgaagaaat ggcaaaggaa ctgcagagca tcgaggccga
    22981 atacgtattc ttctgcgcct acctggcacg cgacgatccc gccgaagcca ctcgcgtcaa
    23041 tgccgtgatg ctcagcaatt ttattcaggc tctcgagaaa a
//
